Annual Report 2007 - The Hospital for Sick Children

SickKids Healthier Children. A Better World.™ Department of Paediatrics Annual Report 2007–08

“A child’s life is like a piece of paper on which every passerby leaves a mark.” - Chinese proverb

Contents 2

Chair’s Report

6

Division of Adolescent Medicine

14

Division of Cardiology

26

Division of Clinical and Metabolic Genetics

34

Division of Clinical Pharmacology & Toxicology

46

Division of Developmental Paediatrics

54

Division of Endocrinology

62

Division of Gastroenterology, Hepatology and Nutrition

74

Division of Haematology/Oncology

90

Division of Immunology/Allergy

96

Division of Infectious Diseases

104

Division of Neonatology

116

Division of Nephrology

122

Division of Neurology

134

Division of Paediatric Emergency Medicine

140

Division of Paediatric Medicine

148

Division of Respiratory Medicine

156

Division of Rheumatology

164

Bloorview Kids Rehab

166

Transplant Centre

168

Paediatric Housestaff

170

Paediatric Grand Rounds

173

Promotions/Recognition

174

Awards

175

Resident and Fellow Awards and Achievements

178

Annual Resident and Fellow Research Day

Chair’s Report

2007-08 was a very special year in the Department of Paediatrics at the The

Farid Mahmud (Endocrinology), Mahendra Moharir (Neurology) and Rulan Parekh

Hospital for Sick Children and University of Toronto: one, not only of security,

(Nephrology). This group represents the full spectrum of job profiles: clinician

but also about renewal, growth and development, innovation and recognition.

scientists, investigators, teachers, educators and specialists. The department and hospital will be well served for many years to come by this highly talented group.

Security was present in our funding plan which has underpinned our ability to recruit new, and retain the existing, outstanding faculty. Last year our ranks were

There have been and will also be more transitions in the months and year to come.

enormously enriched by the appointment of new Division Heads in Endocrinology

Searches are underway in at least three divisions for new heads. At the Paediatric

(Mark Palmert), Developmental Paediatrics (Darcy Fehlings), Rheumatology (Brian

Executive level, Rayfel Schneider has seamlessly taken over as Associate Chair of

Feldman) and Gastroenterology, Hepatology and Nutrition (Anne Griffiths), as well

Medical Education and his team has already garnered some impressive awards:

as David Grant as the new Director of the SickKids Transplant Centre. In addition,

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we have been able to build by recruiting to most divisions: Aleixo Muise

Adelle Atkinson (Director of Postgraduate Medical Education), the PAIRO Residency

(Gastroenterology/Hepatology/Nutrition), Sarah Alexander and Angela Punnett

Excellence Award for our program in Paediatrics; Stacey Bernstein (Director of

(Haematology/Oncology), Anu Wadhwa (Infectious Diseases), Luc Mertens and Lars

Undergraduate Medical Education), a W.T. Aikens Award for small group teaching;

Gross-Wortmann (Cardiology), Sarah Bowdin (Clinical Genetics), Chris Tomlinson

Karen Leslie (Adolescent Medicine), the Helen Batty Award for Faculty Development;

and Linh Ly (Neonatology), Theo Moraes (Respiratory Medicine), Yaron Finkelstein,

Jonathan Pirie (Emergency Medicine) and Ben Saxon (Haematology/Oncology)

Sanjay Mehta and Trent Mizzi (Emergency Medicine), Zia Bizmilla (Paediatric

awards for excellence in postgraduate education; and Anna Banerji (Infectious

Medicine), Angela Orsino and Evdokia Anagnostou (Developmental Paediatrics),

Diseases), the Educational Excellence in Community Care Award.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

These awards are, I believe, a direct result of the commitment we have made

Besides the plethora of awards in education, there are also many examples

as a department to excellence in education. The addition of an education scholar

of achievement in research and clinical care. In 2005-06, the year for which

to the department in early 2009 will further enhance our commitments, as will

we have the latest figures, the department ranked second amongst clinical

our ongoing support of faculty development in education. More challenges await

departments in the Faculty of Medicine in the amount of external grant funding:

as we expand the size of the Medical School classes and move to an even more

over $41 million! Annually, we publish over 750 papers, our faculty present at

distributed model of education. In the meantime, we continue to increase the size

all the major meetings: plenary sessions, workshops and original research. The

of our residency program and our fellowship trainees. Each year, the group coming

culture of research, as has been planned, permeates all aspects of our activities.

to our program seems more talented than ever before. The theme of the photos

New team grants have been awarded by the CIHR recently in asthma (PJ Subbarao

for this annual report is, quite appropriately, Commitment to Education.

and colleagues) and obesity (Brian McCrindle, Jill Hamilton and their extensive

After seven years as Associate Chair of Research, Norman Rosenblum is taking

and Meredith Irwin (Haematology/Oncology), Anne Opavsky (Infectious Diseases)

on a new and exciting challenge: Director of Clinician-Scientist Training Programs

and Rae Yeung (Rheumatology). Berge Minassian has been recognized nationally

in the Faculty of Medicine at the University of Toronto. Norm has made major

and internationally for his groundbreaking work in epilepsy, and David Malkin has

contributions to the development of our department’s research efforts and

been feted by the Israel Cancer Research Foundation as a Man of Distinction.

group), and personal awards to Bob Jankov (Neonatology), Uri Tabori, Lillian Sung

deserves our enormous thanks and best wishes. Meredith Irwin (Haematology/ Oncology) will take over this role and I have no doubt will bring her enormous

The Resident Research Day in May 2008 was once more a great success with

energy, enthusiasm and her own stamp to the task.

over 110 oral and poster presentations by our trainees. This year’s keynote speaker, David Dunger, Professor of Pediatrics from Cambridge University, U.K.,

We thank also Seonag Macrae, now SickKids Executive Vice-President, for so ably

wonderfully illustrated the development and evolution of a career in clinical

representing the Child Health Services portfolio on the Paediatric Executive from

research. The winners of the resident awards are listed on page 175.

2003 to 2008, and welcome her replacement, Marilyn Monk, who is already actively engaged in numerous issues of mutual importance to the hospital and department.

Clinical innovations and excellence abound. Just a few examples: Eyal Cohen and colleagues are following the legacy of Dr. Norman Saunders in pursuing

Once again, the Department of Paediatrics performed superbly in the annual

new models for the care of children with complex care needs; Andrew Redington

Faculty of Medicine promotions process. Debra Katzman (Adolescent Medicine)

and his group in Cardiology and the Labatt Family Heart Centre are breaking new

is now professor, and the group of 11 listed on page 173, are all now associate

ground in the Cardiac Diagnostic and Interventional Unit (CDIU) which opened last

professors: this is a richly deserved recognition of their academic achievements.

year; Jill Hamilton and an interdisciplinary group are probing new approaches to the management of hypothalamic obesity; Sylvain Baruchel is testing new cancer therapies in Phase I clinical trials, and the entire Oncology group participates in the relentless success of the Children’s Oncology Group, as they continuously improve the outcomes of childhood cancers.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

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A couple of new endowed chairs were announced in the past year: Andrew Redington

academic and community positions. Second, we are now in a period of growth in

has been awarded the BMO Financial Group Chair in Cardiology and Earl Silverman,

the health-care sector. How long can this be sustained? Third, our capabilities in

Rheumatology, the Ho Family Chair in Autoimmune Diseases. On page 174, we list

all three pillars of academia have long since outstripped the capacity of our physical

all the winners of the departmental awards-heartiest congratulations to all.

plant: things are going to be quite tight until the new buildings are completed. Fourth, our training programs are being pulled in a number of different directions, including

We have initiated two new programs within the department: first, the transition

the need to train more Canadians in a number of subspecialties, as well as meeting

position aimed at senior trainees wishing to spend one to two more years honing

our social responsibilities by helping to train paediatric subspecialists who return to

their academic skills before assuming a faculty position, and second, a faculty

the developing world. Finally, we need to pay increasingly close attention to clinical

development program that encourages the members of our department to spend

care, focussing on excellence, access, safety and innovation.

periods of time away from SickKids and the University of Toronto, acquiring new skills which they can bring back to enrich their own careers as well as our activities.

In closing, it continues to be an honour and joy to serve as the chair/chief of this department. I am given daily reminders, not only at home but everywhere I go in the

But we are not this successful in isolation. The support of the administration at

world, of just how accomplished our faculty is. Thanks to all for your wonderful work

SickKids and the Decanal Office in the Faculty of Medicine is essential to all of

on behalf of the department, hospital, and university, but mostly for the children

our activities. Mary Jo Haddad, SickKids President and CEO, and Cathy Whiteside,

and their families who entrust us with their lives.

U of T Dean of Medicine, remain staunch supporters of our department. I cannot overstate our appreciation for the efforts of Mary Jo, Cathy and their teams. So is everything rosy, or are there challenges that need our attention? The past five years have seen enormous new recruitment to our faculty. The pace of growth is very unlikely to continue indefinitely; in fact, the job market may become overheated with a limit on new academic positions for highly trained individuals. There is a need for an ongoing nationwide dialogue on the training of paediatricians for both

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THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

DENIS DANEMAN, MB, BCh, FRCPC Chair of Paediatrics, University of Toronto Paediatrician-in-Chief, The Hospital for Sick Children R.S. McLaughlin Chair in Paediatrics, at The Hospital for Sick Children

Thanks to all for your wonderful work on behalf of the department, hospital, and university, but mostly for the children and their families who entrust us with their lives. - Dr. Denis Daneman

Dr. Miriam Kaufman

DIVISION HEAD Dr. Debra K. Katzman FULL-TIME Dr. Eudice Goldberg Dr. Miriam Kaufman Dr. Karen Leslie Dr. Cathleen Steinegger

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PART-TIME Dr. Miriam Rossi Dr. Rahul Saxena

Dr. Boonying Manaboriboon Dr. Ellie Vyver Dr. Mona Basker

CLINICAL FELLOWS Dr. Rosawan Areemit Dr. Abigail Harrison-Kong Dr. Nuray Kanbur

ADMINISTRATIVE STAFF Sharon Dolphin Melissa Keown Burnett Wint

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Division of Adolescent Medicine OVERVIEW

The goal of the Good 2 Go Transition Program is to

The team continues to collaborate with programs/

The Division of Adolescent Medicine provides

prepare all youth with chronic health conditions to

clinics within the hospital and with community

state-of-the-art, comprehensive specialty care to

leave SickKids by the age of 18 with the necessary skills

partners. The Transition Program offers supervision

patients up to 18 years of age, focusing its clinical

and knowledge to advocate for themselves, maintain

and mentorship to interdisciplinary trainees in the

activities in five program areas: eating disorders,

health-promoting behaviours and utilize adult

area of transition.

transition (Good 2 Go), substance abuse, young

health-care services appropriately and successfully. The Transition Program’s poster presentation,

families and complex adolescent problems. The Eating Disorders Program at SickKids continues

The team continues to develop and customize new

The Good 2 Go Transition Program: Helping Programs

resources, including colourful clinic posters and

Promote Healthy Transitions from the Paediatric to

to provide a variety of integrated clinical services

timelines to encourage patients, families and

the Adult Health-Care Systems, was awarded best

(inpatient, day treatment, outpatient and consultation)

practitioners to begin preparing for transition to adult

poster at the Interprofessional Practice Symposium

to adolescents and their families. All aspects of the

care. MyHealth Passport, an initiative introduced last

held at SickKids in November 2007. In addition, the

program are multidisciplinary and family-based,

year, is being evaluated and used in a research project

Good 2 Go Transition Program was recognized by the

allowing for the flexibility in the program to best meet

in the Inflammatory Bowel Disease Clinic.

2007 accreditation team as one of five leading practices in the hospital.

the particular needs of each individual adolescent. New initiatives have included the integration of

The team has recently received funding from the SickKids

multi-family group therapy (MFGT) at SickKids and

Foundation to develop clinical pathways for youth, ages

The Adolescent Substance Abuse Outreach Program

throughout the province. MFGT was recognized by

12 to 18 years. The pathways will be used at clinic visits

and the Substance Abuse Day Treatment Program

the 2007 accreditation team as one of five leading

throughout the hospital, ensuring that staff are

offer comprehensive clinical care to adolescents

practices in the hospital. The highly successful

consistently aware of their role in facilitating transition.

and their families with substance abuse problems.

Ontario Community Outreach Program (a collaborative

The team also received funding from the Kidney

The spectrum of services includes both outpatient

of SickKids, University Health Network and the

Foundation of Canada to work collaboratively with staff

services as well as more intensive, five days a week

MOHLTC) continues to train health-care professionals

from the University Health Network to explore the best

day treatment. Patients receive health assessments

around the province to assess and treat eating

way to modify an existing adult self-management program

and follow up that address both the medical sequelae

disorders, thus allowing more patients to receive

for use with youth who have chronic health conditions.

of their substance use, as well as the other medical

care in their own community.

concerns that result from high-risk health behaviours.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

7

to reduce high-risk health behaviours by promoting

The Day Treatment Program expanded its services last

both at local and regional levels, and provide

year to include a summer program, combining

expertise in child and youth substance use and abuse

healthy sexuality and healthy sexual relationships;

treatment, academic and medical support to day

to various committees dealing with prevention and

assistance to health-care teams in recognizing the

treatment patients. This summer’s program will

treatment issues at the municipal, provincial, and

role of the mind and body regarding various health-

build upon the success of last year’s experience.

national levels. Expertise in the area of substance

care processes; and maintaining a presence within

abuse prevention has been highlighted this year

the community to advocate for the health-care

The program also provides training and education

through work with the City of Toronto task force

needs of youth. These services are provided in the

to many levels of learners from different health

and working group on substance abuse prevention.

Adolescent Clinic as well as in collaboration with renal, cardiac and lung transplant programs, the HIV and

professions, including postgraduate Paediatrics and

SLE clinics, and through inpatient consultations. Last

Psychiatry, and child and youth counselling trainees.

The Substance Abuse Program is building on prior

New training initiatives for Adolescent Medicine

collaboration with the Centre for Addiction and Mental

year, a combined CAPP/SCAN (Suspected Child Abuse

fellows that were implemented last year have been

Health for a project that will pilot screening and

and Neglect) clinic was established to collaboratively

further enhanced. As well, specialized training in

assessment tools for youth with substance abuse,

assess and provide education and support for

substance use and abuse for paediatric residents

other high-risk behaviours and concurrent disorders.

adolescents identified as engaging in high-risk sexual behaviours. This past year, the CAPP clinic created a

has been launched with the creation of a new interdisciplinary clinic specifically addressing the

The Complex Adolescent Problem Program (CAPP)

new link to the Substance Abuse Treatment Program

complex needs of patients in the Substance Abuse

continues to focus on adolescents with chronic illness,

allowing youth in the Substance Abuse Program to

Program. In addition to the many outreach educational

disability or complicated medical conditions. The goal

receive their medical care in an interdisciplinary clinic

activities of the program, staff presented at national

of CAPP is to provide access to expert adolescent

involving team members from both programs. CAPP

and international conferences this year at the invitation

health-care services to youth, both within the

continues to build partnerships with local agencies

of leaders in the fields of paediatric health-care and

community and those already patients at SickKids.

in an effort to enable youth in the downtown core

congenital heart disease. Members of the staff are

Objectives of the program include provision of

to access health information and necessary health

involved in many aspects of service development,

comprehensive multidisciplinary care in an effort

services otherwise unavailable to them. In addition, collaboration with the Toronto Children’s Aid Society

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THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

for youth in care to access medical and psychosocial

Assessment and intervention in the areas of growth

activities include the medical complications of eating

services. Increasingly, the CAPP team is being

and development, infant and adolescent mental health,

disorders with specific emphasis on osteoporosis and

consulted regarding youth with clinical conditions

maltreatment, and social determinants of health

brain structure and function, epidemiology of early-

that are considered diagnostic dilemmas.

provide the basis for research in adolescent parenting.

onset eating disorders, evaluation of family-based

Management of these conditions requires an

The project is now completing the assessment phase

treatments for adolescents with eating disorders,

interdisciplinary team skilled in understanding

and is entering the intervention phase with an emphasis

the evaluation of the use of information technology

the interplay of physical and emotional factors

on maternal and infant mental health, and ultimately

for health promotion with youth, treatment outcome

that contribute to presenting symptoms.

improving child/parent relationships. Interprofessional

in adolescent substance use, HIV educational

team members continue to provide resources and

interventions with incarcerated youth, health values

The Young Families Program (YFP) focuses on providing

education to health professionals in a variety of

in adolescents with chronic illnesses, the assessment

health care, advocacy, support and education to

settings through conference presentations and

and evaluation of high risk parents and their children,

high-risk adolescent parents and their children. The

committee participation.

the evaluation of transition of care to the adult healthcare system, and faculty development and mentoring.

YFP collaborates with several agencies that provide services to a diverse group of adolescent parents,

The Division of Adolescent Medicine at SickKids is

including prenatal homes, health services and child

the largest of its kind in Canada, with a diverse

The division trains physicians (from Paediatrics,

protection agencies. In particular, the YFP provides a

interprofessional clinical team and staff. This past

Psychiatry and Family Medicine), nurses, psychologists,

consultation clinic at Jessie’s Centre for Teenagers

year, two nurses in Adolescent Medicine successfully

social workers, dietitians, art therapists and child

and provides educational, supportive and policy

passed the newly instituted nurse practitioner

youth counsellors in all aspects of adolescent health.

recommendations. In partnership with the SCAN team,

examination and are now registered with the College

the High Risk Project has been operational since

of Nurses of Ontario as nurse practitioners.

Members of the division continue to make significant educational contributions locally, provincially, nationally

2004 when external funding was established to standardize clinical care for adolescent parents

Research activities are an integral part of the activities

and internationally. Members of the division hold

and their children.

of the faculty and trainees of the division. The division

leadership roles in the SickKids Summer Student

has significantly expanded its research, addressing

Program, the Centre for Faculty Development, and

a multitude of adolescent health issues. Research

organizing international annual scientific meetings on adolescent health.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

9

Division members play a leading role in national

PUBLICATIONS

and international clinical, education and research

Bravender T, Bryant-Waugh R, Herzog D, Katzman D,

Pinzon J, McDuff P: Sex and sexual health: A survey

committees, including the Infant Mental Health

Kreipe RD, Lask B, Le Grange D, Lock J, Loeb K,

of Canadian youth and mothers. Paediatrics and Child Health 2008: 13(1): pp 25-30.

Frappier J, Kaufman M, Baltzer F, Elliott A, Lane M,

Promotion Project, Canadian Paediatric Society,

Madden S, Nicholls D, O’Toole J, Pinhas L, Rome E,

American Academy of Paediatrics, Society for

Sokol-Burger M, Wallen U, Zucker N: workgroup for

Adolescent Medicine, Canadian Association for

classification of eating disorders in children and

Infectious Diseases and Immunization Committee

Adolescent Health, Canadian Association for Medical

adolescents. Classification of child and adolescent

(Bortolussi R, Moore DL, Robinson JL, Rousseau-

Education and the Academy for Eating Disorders.

eating disturbances. Workgroup for classification

Harsany E, Samson LM (Principal Author) and

of eating disorders in children and adolescents

Adolescent Medicine Committee (Findlay S, Pinzon J,

Over the past three years, the division has taken the

(WCEDCA). International Journal of Eating Disorders

Taddeo D, Katzman DK), Canadian Paediatric Society

lead in pursuing paediatric subspecialty certification

2007: 40(Suppl): pp S117-S122.

(CPS): HPV vaccine for children and adolescents. Paediatrics and Child Health 2007: 12(7): pp 599-603.

for Adolescent Medicine through the Royal College of Physicians and Surgeons of Canada (RCPSC).

Egan-Lee E, Hollenberg E, Dematteo D, Tobin S,

Adolescent Medicine was endorsed at the RCPSC’s

Oandasan I, Beduz A, Kwan D, Leslie K, Lee J,

Jayaraman GC, Shields S, Rossi M, Haase D, Singh A,

Council in May 2007, and is now the 63rd recognized

Tassone M, Merkley J, Lingard L, Sinclair L, Lowe M,

Predy G, Neudorf C, Ogilvie G, Rekart M, Beaudoin C,

Reeves S: Catalyzing and sustaining communities

Hammond G, Toye B, Wong T and the SY-Track Study

of collaboration around interprofessional care: An

Team: Street youth in Canada: findings from enhanced

HONOURS AND AWARDS

evaluation of four educational programs. Journal of

surveillance of Canadian street youth, 1999-2003.

Katzman DK: Eating Disorder Champion Award, 2007.

Interprofessional Care 2008: 22(3): pp 317-319.

Ottawa, ON: Public Health Agency of Canada, 2006.

discipline of the RCPSC as a subspecialty of Paediatrics.

Cat. No. HP5-15/2006 ISBN 0-662-49069-X. Leslie K: Helen Batty Award for Teaching in Faculty Development, 2008.

10 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Accessed March 5, 2007.

Misra M, Prabhakaran R, Miller KK, Goldstein A,

Katzman DK, Frappier JY, Goldberg E: Adolescent

Leslie K: Youth substance use and abuse: challenges

medicine: a new paediatric subspecialty in Canada.

and strategies for identification and intervention.

Mickley D, Clauss L, Lockhart P, Cord J, Herzog DB,

(Invited submission). Paediatrics and Child Health

Canadian Medical Association Journal 2008: 178(2):

Katzman DK, Klibanski A: Weight gain and restoration

2008: 13(1): pp 12-14.

pp 145-148.

of menses as predictors of bone mineral density

Katzman DK: Irregular menses: a warning sign of

Leslie K: Harm reduction: an approach to reducing

Journal of Clinical Endocrinology and Metabolism

vomiting for weight control. Journal of Adolescent

risky health behaviours in adolescents. Paediatrics

2008: 93: pp 1231-1237.

Health 2008: 42(5): pp 429-431.

and Child Health 2008: 13(1): pp 53-56.

change in adolescent girls with anorexia nervosa-1.

Richardson D, Glover TS, Nasmith L, Leslie K, Kirsh G, McVey G, Tweed S, Katzman DK:

Misra M, Miller KK, Cord J, Prabhakaran R,

Bandiera G, Paterson M, Power B, Oandason I, Frank

Psychosocial profiles of young adolescent females

Goldstein M, Katzman DK, Herzog DB, Klibanski A:

JR: The CanMEDS train-the-trainer collaborator faculty

seeking treatment for an eating disorder. Journal of

Relationships between serum adipokines, insulin

development program. Ottawa: The Royal College of

levels and bone density in girls with anorexia nervosa.

Physicians and Surgeons of Canada 2007.

Adolescent Health 2007: 40(4): pp 351-356.

Journal of Clinical Endocrinology and Metabolism Korszak D, Connolly B, Baron T, Katzman DK,

2007: 92(6): pp 2046-2052.

Steinegger C, Katzman DK: Interviewing the adolescent with an eating disorder. Adolescent

Bernstein S: Safety and efficacy of image-guided gastrostomy (G) and gastrojejunostomy (GJ) tubes

Misra M, Prabhakaran R, Miller KK, Goldstein MA,

Medicine State of the Art Reviews 2008: 19(1):

in children and adolescents with primary psychiatric

Mickley D, Clauss L, Lockhart P, Cord J, Herzog DB,

pp 18-40.

illness. International Journal of Eating Disorders

Katzman DK, Klibanski A: Prognostic indicators of

2007: 40(7): pp 645-651.

changes in bone density measures in adolescent

Tallett S, Lingard L, Hellmann J, Hilliard R, Hurley J,

girls with anorexia nervosa. Journal of Clinical

Leslie K, Jefferies A, Mian M, Pirie J, Rosenfield J,

Endocrinology and Metabolism 2008: 93(4):

Schneider R, Spero L: Measuring educational

pp 1292-1297.

workload: a pilot study of paper-based and PDA tools. Medical Teacher 2008: 30(3): pp 296-301.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 11

FUNDING

Vyver E, Steinnegger C, Katzman DK: Eating disorders

Pinhas L, Katzman DK, Dimitropoulos G, Woodside B:

and menstrual dysfunction in adolescents. Annals

Binging and bulimia nervosa in children and adolescents.

Bulimic eating disorders in children and adolescents:

of the New York Academy of Sciences 2008: 1135:

In: Child and Adolescent Eating Disorders (Jaffa T,

Canadian Paediatric Surveillance Program (CPSP).

pp 253-264.

McDermott, eds.). New York: Cambridge University

Pinhas L, Heinmaa M, Boachie A, Crosby R, Katzman

Press, 2007.

DK (Senior Investigator). Psychiatric Endowment

BOOKS AND BOOK CHAPTERS

Fund at SickKids ($24,000, 2007-2008).

Adolescent Health Care, A Practical Guide, 5th Edition

Pinhas L, Steinegger C, Katzman DK: Clinical

(Neinstein LS, Gordon CM, Katzman DK, Rosen DS,

assessment and physical complications. In:

Development and testing of a self-management

Woods ER, eds.). Philadelphia: Lippincott Williams

Eating Disorders in Childhood and Adolescence,

program for youth post kidney transplant: a Paediatric

and Wilkins, 2007.

3rd Edition (Lask B, Bryant-Waugh R, eds.).

and adult care collaboration. Kidney Foundation

London: Brunner-Routledge, 2007.

of Canada Grant ($90,000, 2008-2010).

Adolescent Health Care LITE (Neinstein LS, Gordon CM, Katzman DK, Rosen DS, Woods ER, eds.).

Steinegger C: Nutrition. In: Adolescent Medicine:

Development and testing of a self-management

Philadelphia: Lippincott Williams and Wilkins, 2007.

The Requisites in Pediatrics (Slap GD, ed.).

program for youth post kidney transplant: A paediatric

Philadelphia: Mosby Inc., 2008.

and adult care collaboration. Dettmer E, Cullen-Dean

Katzman DK, Golden NE: Eating disorders. In: Adolescent

G, D’Agostino N, Kaufman M, Lorber S, Mitchell M,

Health Care: A Practical Guide, 5th Edition (Neinstein

Schiff J, Pool R. RN Funding Kidney Foundation

L, Gordon C, Katzman DK, Rosen D, Woods E, eds.).

of Canada ($85,134, 2008).

Philadelphia: Lippincott Williams and Wilkins, 2007.

12 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Effects of anorexia nervosa on peak bone mass.

Creating transition clinical pathways. Kaufman M,

Klibanski A, Katzman DK, Misra M, Herzog D,

Cullen-Dean G, Dettmer E, Lorber S, Horricks L.

Levitsky L. National Institute of Health/NIDDK

Sun Life Financial ($25,000, 2008).

($3,801,660, 2003-2008). Leadership: creating communities of practice for Faculty development to support capacity building

interprofessional collaboration (IPC) in Toronto.

for interprofessional education. Leslie K, Reeves S,

Kwan D, Leslie K, Lieff S, Nasmith L, Oandasan I.

Silver I, Merkley J, Richardson D, Wagner S, Andrews

Reeves S, Silver I. Ministry of Health and Long-Term

M, Kwan D. Ministry of Health and Long-Term Care

Care Interprofessional, Mentorship, Preceptorship,

($310,000, 2008).

Leadership and Coaching Fund ($1,200,000, 2007).

Family therapy and fluoxetine in the treatment of

Youth with chronic health conditions: tell us how we

adolescent anorexia nervosa. Agras S, Brandt H,

can best teach you self-management skills. Mitchell M,

Halmi K, Johnson C, Kaye W, Wilfley D, Woodside B,

Rivers P, McCurdy C, D’Agostino N, Dettmer E,

Pinhas L, Katzman DK. National Institute of Mental

Cullen-Dean G, Lorber S, Harrison-Kong A, Kaufman M,

Health ($6,250,000 2007-2012).

Pool R. Funding UHN Allied Health Research Award ($1,158, 2008).

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 13

Dr. Edgar Jaeggi

DIVISION HEAD Dr. Andrew Redington FULL-TIME Dr. Lee Benson Dr. Tim Bradley Dr. Rajiv Chaturvedi

Dr. Anne Dipchand Dr. Mark Friedberg Dr. Fraser Golding Dr. Gil Gross Dr. Robert Hamilton Dr. Edgar Jaeggi Dr. Paul Kantor

Dr. Joel Kirsh Dr. Kyong-Jin Lee Dr. Brian McCrindle Dr. Luc Mertens Dr. Seema Mital Dr. Jennifer Russell Dr. Elizabeth Stephenson

14 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

PART-TIME Dr. Tiscar Cavalle-Garrido Dr. Jack Colman Dr. Rejane Dillenburg Dr. Ra Han Dr. Alexandra Jevremovic Dr. Anilkumar Menon

Dr. Tapas Mondal Dr. Norman Musewe Dr. Lynne Nield Dr. Erwin Oechslin Dr. Dionissios Pepelassis Dr. Rachel Wald Dr. Roxanne Walker

ADJUNCT Dr. Fred Keeley (Research Scientist) CROSS-APPOINTED Dr. Desmond Bohn Dr. Tilman Humpl Dr. Afrothite Kotsakis

Division of Cardiology OVERVIEW

multi mode research, investigation and treatment,

and tissue samples will be held for future fundamental,

The Division of Cardiology was formally established in

setting the scene for MRI-guided interventional

translational and clinical research investigations.

the 1940s and is now one of the largest and most

procedures and physiologic measurements in children. The Royal College accredited Paediatric Cardiology

successful in the world. Its philosophy has remained unchanged since its inception over 60 years ago: to

The cardiovascular research focus within the Research

Training Program is the largest in Canada and one of

provide the highest quality care in an evidence-based

Institute has made fundamental contributions to our

the largest and most sought after in North America.

environment of clinical innovation and scientific discovery. Over the past decade, the divisional activities, in

understanding of the cellular biology and molecular

As such, its fellows have populated cardiology groups

genetics of pulmonary vascular bed, with recent

throughout the world, many going on to become

diversification to include the study of the fetal myocyte,

leaders of our specialty.

close collaboration with surgical and intensive care

detailed study of the intercellular structure of the heart

colleagues, have contributed to our markedly improved

and vessels, electrophysiology of the developing heart

The single most important development of the last

preoperative diagnosis and postoperative outcomes

and immunology of cardiac transplantation. While

decade, however, has been the establishment of

for children undergoing cardiac surgery, led the field

undergoing a change in leadership, it is expected that

the Labatt Family Heart Centre. Following a series

in development of therapeutic catheter techniques,

high quality basic and translational research, with an

of important internal initiatives, the extraordinary

made important contributions to our understanding of

emphasis on direct clinical applicability, will continue

generosity of the Labatt family has funded the

fetal cardiac medicine, established one of the largest

to form the bedrock of our academic program. As an

redevelopment and future activities of the Heart

paediatric cardiac transplantation centres worldwide,

example, the Heart Centre is making a major investment

Centre at SickKids.

and has won international recognition for its contribution

in the development of a biobank facility in which DNA

in the field of epidemiology of acquired and congenital heart disease and surgical outcomes. Each of these areas has provided the substrate for the large clinical research output of the division which is underpinned by a world-class laboratory science program. One of

Dr. Joel Kirsh and patient

the recent exciting clinical developments was the commissioning of an integrated suite of catheter laboratories and magnetic resonance scanning facilities. This unique fusion will allow ‘simultaneous’

Dr. Steven Schwartz Dr. Ben Sivarajan Dr. Shi-Joon Yoo

RESEARCH ASSOCIATES La Rotta, Gustavo Dr. Jing Li

CLINICAL FELLOWS Jaime Alkon Abdulmajeed Al-Otay Armando Alfaro-Ramirez Alexandra Bauch Jose Castro-Sancho Robin Clegg

Matthew Crystal Yousef Etoom Deborah Fruitman Brian Grant Lars Grosse-Wortmann Damian Hutter Rubeena Khan

CLINICAL FELLOWS Anders Nygren Dragos Predescu Mark Walsh Roland Weber

RESEARCH FELLOWS

SUBSPECIALTY RESIDENTS

Christian Apitz Kentaro Asoh Jae-Young Lee Jan Møller Nielsen Lucy Roche

Alejandro Floh Marko Vezmar Derek Wong

DEPARTMENTAL FELLOW Ricardo Ayala-Arnez

The Hospital for Sick Children 2007-08 ANNUAL REPORT 15

HONOURS AND AWARDS

Mital S: Roma and Marvin Auerbach Professorship

Golding F: Operational Director of Echocardiography,

(Endowment) in Developmental Biology and Congenital

Mori A, Li J, Liu PP, Redington AN, Coles JC: Early

Cardiology, The Hospital for Sick Children. February,

Heart Research, 2007.

gene expression profiles during intraoperative

Redington A: BMO Financial Group Chair in Cardiology,

Journal of Thoracic and Cardiovascular Surgery 2007:

The Hospital for Sick Children, 2008.

134(1): pp 74-81.

Arab S, Konstantinov IE, Boscarino C, Cukerman E,

myocardial ischemia-reperfusion in cardiac surgery.

2008. Golding F: Medical Director of Telemedicine, The Hospital for Sick Children. June, 2008. Gross G: Schwartz-Reisman Visiting SickKids Scholarship, The Hospital for Sick Children. 2008.

PUBLICATIONS

Atz AM, Cohen MS, Sleeper LA, McCrindle BW, Lu M,

Akikusa JD, Feldman BM, Gross GJ, Silverman ED,

Prakash A, Breitbart RE, Williams RV, Sang CJ,

Schneider R: Sinus bradycardia following intravenous

Wernovsky G: Functional status of patients with

‘pulse’ methylprednisolone. Pediatrics 2007: 119: Hamilton R: Featured Research, Canadian

pp e778-e782.

heterotaxy syndrome following the Fontan operation. Cardiology in the Young 2007: 17(2): pp 44-53.

Cardiovascular Congress: abnormal cardiomyocyte connexin expression in arrhythmogenic right

Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G,

Bernasconi A, Cavalle-Garrido T, Redington AN:

ventricular cardiomyopathy caused by heterozygous

Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S:

Spontaneous intraoperative ventricular hematoma

desmosomal protein mutations, 2007.

Fatal infantile cardiac glycogenosis with phosphorylase

in a neonate. Heart 2007: 93(8): p 898.

kinase deficiency and a mutation in the gamma Kantor P: BCCA Leeds 2007 Award for the Best

2-subunit of amp-activated protein kinase. Pediatric

Poster Presentation. “Sudden death of heart disease

Research 2007: 62(4): pp 499-504.

undiagnosed during the lifetime in children: pathology survey and review of the literature.” British Congenital

Bernheimer J, Friedberg MK, Chan FP, Silverman NH: Echocardiographic diagnosis of persistent fifth aortic arch. Echocardiography 2007: 24(3): pp 258-262.

Alsoufi B, Cai S, Williams WG, Coles JG, Caldarone CA,

Cardiac Association (BCCA) Annual Meeting, Leeds,

Redington AM, Van Arsdell GS: Improved results with

Berul CI, Villafane J, Atkins DL, Cecchin F, Kirsh JA,

UK, 2007.

single-stage total correction of Taussig-Bing anomaly.

Johns JA, Kanter RJ, Karpawich PP: Pacemaker lead

European Journal of Cardiothoracic Surgery 2008:

prolapse through the pulmonary valve in children.

Lee J: Promoted to Associate Professor of Paediatrics,

33(2): pp 244-250.

Faculty of Medicine, University of Toronto, 2008.

ADMINISTRATIVE STAFF Shazia Ali (contract) Fe Berbano (contract) Theresa Braggs Sandra Brisebois Paula Capela

Tracey Clatworthy (contract) Esther Delea Karen Hodgson Susan Jessop Shelley Marks Fran Matthews Shloka Mirchandaney

Pacing and Clinical Electrophysiology 2007: 30: pp 1183-1189.

Andrea Morris Susan Morton Eleanor Paulino Robin Smith (contract) Rooma Vaidya Denise Vanek Shirley Wang

Collins KK, Rhee EK, Kirsh JA, Cannon BA, Fish F,

Bharat W, Manlhiot C, McCrindle BW, Pollock-BarZiv

Chaturvedi RR, Redington AN: Pulmonary regurgitation

SM, Dipchand AI: The profile of renal function over

in congenital heart disease. Heart 2007: 93(7):

Dubin A, Van Hare GF: Cryoablation of accessory

time in a cohort of paediatric heart transplant

pp 880-889.

pathways in the coronary sinus in young patients: a multicenter study from the paediatric and

recipients. Pediatric Transplantation December 18, 2007 [Epub ahead of print].

Cherney D, Miller J, Scholey J, Bradley TJ, Slorach C,

congenital electrophysiology society’s working

Curtis J, Dekker M, Nasrallah R, Hebert R, Sochett E:

group on cryoablation. Journal of Cardiovascular Electrophysiology 2007: 18: pp 592-597.

Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS,

The effect of cyclooxygenase 2 inhibition on renal

Quaegebeur JM, Addonizio LJ, Hsu DT, Chen JM:

hemodynamic function in humans with Type 1

Twenty-year experience with heart transplantation for

diabetes mellitus. Diabetes 2008: 57(3): pp 688-695.

Bernstein D, Williams GE, Eisen H, Mital S,

1986-2006. American Journal of Transplantation

Cherney DZ, Scholey JW, Nasrallah R, Dekker MG,

Gene expression profiling distinguishes a molecular

2008: 8: pp 2001-2007.

Slorach C, Bradley TJ, Hébert RL, Sochett EB, Miller JA.

signature for Grade 1B mild acute cellular rejection

Wohlgemuth JG, Klingler TM, Fang KC, Kobashigawa J:

infants and children with restrictive cardiomyopathy:

Renal hemodynamic effect of cyclooxygenase 2

in cardiac allograft recipients. Journal of Heart

Bradley TJ, Karamlou T, Kulik A, Mitrovic B,

inhibition in young men and women with uncomplicated

Transplantation 2007: 26(12): pp 1270-1280.

Vigneswaran T, Jaffer S, Glasgow PD, Williams WG,

Type 1 diabetes mellitus. American Journal of

Van Arsdell GS, McCrindle BW: Determinants of repair

Physiology–Renal Physiology 2008: 294(6):

type, reintervention, and mortality in 393 children with

pp F1336-F1341.

Davies RR, Russo MJ, Mital S, Martens TM, Sorabella RS, Hong KN, Gelijins AC, Moskowitz AJ, Quaegebeur JM, Mosca RS, Chen JM: Predicting survival among

double outlet right ventricle. Journal of Thoracic and Collins N, Colman J, Benson L, Hansen M, Merchant N,

high-risk paediatric cardiac transplant recipients:

Horlick E: Successful percutaneous treatment of

an analysis of the United Network Organ Sharing

anomalous left coronary artery from pulmonary artery.

Database. Journal of Thoracic Cardiovacular

Cardiac chamber hypertrophy following hematopoietic

International Journal of Cardiology 2007: 122(3):

Surgery 2008: 135(2): pp 147-155.

stem cell transplantation for primary immunodeficiency.

e29-e31.

Cardiovascular Surgery 2007: 134(4): pp 967-973. Bully SR, Benson L, Grunebaum E, Roifman CM:

Dehghani P, Collins N, Benson L, Horlick E: Role of

Biology of Blood and Marrow Transplantation 2008: 17: pp 229-235.

Collins N, Mehta R, Benson L, Horlick E: Percutaneous

routine radial artery access during aortic coarctation

coronary artery fistula closure in adults: technical

interventions. Catheterization and Cardiovascular

Caldarone CA, Benson L, Holtby H, Li J, Redington AN,

and procedural aspects. Catheterization and

Interventions 2007: 70(4): pp 622-623.

Van Arsdell GS: Initial experience with hybrid palliation

Cardiovascular Interventions 2007: 69: pp 872-880.

for neonates with single-ventricle physiology. Annals of Thoracic and Cardiovascular Surgery 2007: 84(4): pp 1294-1300.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 17

Dehghani P, Collins N, Horlick E, Benson L: Chronic

Estes NA 3rd, Page R, Boyden P, Cappato R, Chiu-Man

Friedberg MK, Silverman NH: The systolic to diastolic

pulmonary thromboembolism in a patient with a Fontan

C, Day J, Dimarco J, Ferrick A, Hamdan M, Hamilton R,

duration ratio in children with hypoplastic left heart

circulation: percutaneous management. Catheterization

Hohnloser S, Jung W, Kanter R, Knight B, Lindsay B,

syndrome: a novel doppler index of right ventricular

and Cardiovascular Interventions 2007: 70: pp 893-896.

Natale A, Reynolds D, Rosenbaum D, Saxon L, Shen

function. Journal of the American Society of

WK, Trayanova N, Wilkoff B: Hightlights of heart

Echocardiography 2007: 20(6): pp 749-755.

Dipchand AI, Bharat W, Manlhiot C, Safi M, Lobach NE,

rhythm 2007, The annual scientific sessions of the

McCrindle BW: A prospective study of dobutamine

heart rhythm society, May, 2007: 4(10): pp e1-e9.

Friedberg MK, Silverman NH, Dubin AM, Rosenthal DN: Mechanical dyssynchrony in children with systolic

stress echocardiography for the assessment of Freedman SB, Haladyn KJ, Floh A, Kirsh JA, Taylor G, Thull-

dysfunction secondary to cardiomyopathy: a doppler

transplant recipients. Pediatric Transplantation 2008:

Freedman J: Myocarditis: clinical findings and diagnostic

tissue and vector velocity imaging study. Journal of

12: pp 570-576.

evaluation. Pediatrics 2007: 120: pp 1278-1285.

cardiac allograft vasculopathy in pediatric heart

the American Society of Echocardiography 2007: 20(6): pp 756-763.

Dong-Sheng G, Wei-Yi F, Chiu-Man C, Kirsh J, Gross G,

Friedberg MK, Feinstein JA, Rosenthal DN: Noninvasive

Hamilton RM: QT hysteresis in long-QT syndrome

assessment of pulmonary arterial capacitance by

Friedberg MK, Silverman NH, Dubin AM, Rosenthal

children with exercise testing. Chinese Medical

echocardiography. Journal of the American Society of

DN: Right ventricular mechanical dyssynchrony in

Journal 2007: 120: pp 179-82.

Echocardiography 2007: 20(2): pp 186-190.

children with hypoplastic left heart syndrome. Journal of American Society of Echocardiography 2007: 20(9):

Dutta S, Mihailovic A, Benson L, Kantor PF,

Friedberg MK, Kim N, Silverman NH: Atrioventricular

Fitzgerald PG, Walton JM, Langer JC, Cameron BH:

septal defect recently diagnosed by fetal

pp 1073-1079.

Thoracoscopic ligation versus coil occlusion for

echocardiography: echocardiographic features,

Gengsakul A, Harris L, Bradley TJ, Webb GD, Williams

patent ductus arteriosus: a matched cohort study

associated anomalies and outcomes. Congenital

WG, Siu SC, Merchant N, McCrindle BW: The impact of

of outcomes and cost. Surgical Endoscopy 2008:

Heart Disease 2007: 2(2): pp 110-114.

pulmonary valve replacement after tetralogy of Fallot

Friedberg MK, Roche SL, Balasingam, Stephenson E,

Cardiothoracic Surgery 2007: 32(3): pp 462-468.

repair: a matched comparison. European Journal of

22(7): pp 1643-1648. Dutta S, Mihailovic A, Benson L, Kantor PF,

Slorach C, Fackoury C, Kantor PF: Evaluation of

Fitzgerald PG, Walton JM, Langer JC, Cameron BH:

mechanical dyssynchrony in children with idiopathic

Gonzalez AMD, Osorio JC, Gruber G, Homma S,

Thoracoscopic ligation versus coil occlusion for

dilated cardiomyopathy and associated clinical

Mital S: Hypertrophy signalling during peripartum

patent ductus arteriosus: a matched cohort study

outcomes. American Journal of Cardiology 2008:

cardiac remodelling. American Journal of Physiology –

of outcomes and cost. Journal of Endovascular

101(8): pp 1191–1195.

Surgery 2008: 22(7): 1643-1648.

18 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Heart and Circulation Physiology 2007: 293(5): pp H3008-H3013.

Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ.

Grosse-Wortmann L, Al-Otay A, Goo HW, Macgowan

Hypertension and Obesity in Youth of the Council on

CK, Coles JG, Benson LN, Redington AN, Yoo SJ:

Cardiovascular Disease in the Young, Council on

Upstairs-downstairs hearts in siblings: prenatal

Anatomical and functional evaluation of pulmonary

Cardiovascular Nursing, Council on Epidemiology and

diagnosis and clinical impact of a rare form of

veins in children by using magnetic resonance imaging.

Prevention, and Council on Nutrition, Physical Activity

congenital malposition of the heart and great arteries.

Journal of the American College of Cardiology 2007:

and Metabolism. Circulation 2007 116(3): pp 344-357.

Cardiology in the Young 2008: 18: pp 337-348.

49: pp 993-1002. Hickey EJ, Blackstone EH, Lofland GK, Yeh T, Pizarro C,

Jaeggi ET, Friedberg MK. Diagnosis and management

Grosse-Wortmann L, Hamilton R, Yo S-J: Massive

Tchervenkov CI, Pigula F, Overman DM, Jacobs ML,

of fetal bradyarrhythmias. Pacing and Clinical

systemic-to-pulmonary collateral arteries in the setting

Caldarone CA, McCrindle BW: Critical left ventricular

Electrophysiology 2008: 31: pp S50-S53.

of a cavopulmonary shunt and pulmonary venous

outflow tract obstruction: the disproportionate impact of biventricular repair in borderline cases. Journal of

Jaeggi E, Ryan G, Schmidt M, Chaturvedi RR. Stenting

Thoracic and Cardiovascular Surgery 2007: 134(6):

of the atrial septum in fetal lambs. Ultrasound in

pp 1429-1436.

Obstetrics and Gynecology 2007: 30: p 496.

an argument that cuts both ways. Heart Rhythm

Hickey EJ, McCrindle BW, Blackstone EH, Yeh T, Pigula F,

Karamlou T, Gurofsky R, Bojcevski A, Williams WG,

Journal 2008: 5: pp 716-717.

Clarke D, Tchervenkov CI, Hawkins J, for the CHSS

Caldarone CA, Van Arsdell GS, Paul T, McCrindle BW:

stenosis. Cardiology in the Young 2007: 17: pp 548-550. Hamilton RM: Genetic testing for mutations or polymorphisms in sudden infant death syndrome:

Pulmonary Conduit Working Group: Jugular venous

Prevalence and associated risk factors for intervention

valved conduit (contegra) matches allograft performance

in 313 children with subaortic stenosis. Annals of

WG, Smallhorn JF, McCrindle BW: Outcome and

in infant truncus arteriosus repair. European Journal

Thoracic Surgery 2007: 84(3): pp 900-906.

growth potential of left heart structures after neonatal

of Cardiovascular Surgery 2008: 33(5): pp 890-898.

Han RK, Gurofsky RC, Lee KJ, Dipchand AI, Williams

Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L,

intervention for aortic valve stenosis. Journal of the American College of Cardiology 2007: 50: pp

Horlick EM, McLaughlin PR, Benson LN: The adult with

Prakash A, Printz BF, Gruber D, Papavassiliou D,

2406-2414.

repaired coarctation of the aorta. Current Cardiology

Hsu DT, Sehnertt A, Chung WK, Mital S. RAAS gene

Reports 2007: 9: pp 323-30.

polymorphisms influence progression of pediatric

Helden L, Ross J, Dennison BA, Steinberger J,

Ilina MV, Jaeggi ET, Lee K-J: Neonatal rhabdomyoma

122(5): pp 515-23.

Williams CL: Primary prevention of cardiovascular

causing right ventricular inflow obstruction with

hypertrophic cardiomyopathy. Human Genetics 2007:

Hayman LL, Meininger JC, Daniels SR, McCrindle BW,

disease in nursing practice: focus on children and

duct-dependent pulmonary blood flow: successful

youth. A scientific statement from the American

stenting of PDA. Catheterization and Cardiovascular

Heart Association Committee on Atherosclerosis,

Interventions 2007: 69: pp 881-885.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 19

Krahn AD, Champagne J, Healey JS, Cameron D,

Li J, Zhang G, Cai S, Redington AN: Effect of inhaled

McCrindle BW, Williams RV, Mital S, Clark BJ, Russell

Simpson CS, Thibault B, Mangat I,Tung S, Sterns L,

hydrogen sulfide on metabolic responses in anesthetized,

JL, Klein G, Eisenmann JC: Physical activity levels in

Birnie DH, Exner DV, Parkash R, Sivakumaran S,

paralyzed and mechanically ventilated piglets.

children and adolescents are reduced after the Fontan

Davies T, Coutu B, Cyrstal E, Wolfe K, Verma A,

Pediatric Critical Care Medicine 2008: 9(1): pp 110-112.

Paredes FA, Essebag V: Outcome of the fidelis

procedure, independent of exercise capacity, and are associated with lower perceived general health. Archives

Stephenson EA, Sanatani S, Gow R, Connors S, Li J, Zhang G, Herridge J, Holtby H, Humpl T,

of Disease in Childhood 2007: 92(6): pp 509-514.

implantable cardioverter-defibrillator lead advisory:

Redington AN, Van Arsdell GS: Energy expenditure

a report from the Canadian Heart Rhythm Society

and caloric and protein intake in infants following the

Minich LL, Sleeper LA, Atz AM, McCrindle BW, Lu M,

Working Group on device advisories. Heart Rhythm

Norwood procedure. Pediatric Critical Care Medicine

Colan SD, Printz EF, Klein GL, Sundel RP, Takahashi M,

2008: 5: pp 639-642.

2008: 9(1): pp 55-61.

Li JS, Vetter VL, Newburger JW: Delayed diagnosis of Kawasaki disease: what are the risk factors?

Lacro RV, Dietz HC, Wruck LM, Bradley TJ, Colan SD,

Li J, Zhang G, Holtby H, Guerguerian AM, Cai S, Humpl

Devereux RB, Klein GL, Li JS, Minich LL, Paridon SM,

T, Caldarone CA, Redington AN, Van Arsdell GS: The

Pediatrics 2007: 120(6): pp e1434-e1440.

Pearson GD, Printz BF, Pyeritz RE, Radojewski E,

influence of systemic hemodynamics and oxygen

Moola F, Faulker GEJ, Kirsh JA, Kilburn J: Physical

Roman MJ, Saul JP, Stylianou MP, Mahony L, for the

transport on cerebral oxygen saturation in neonates

activity and sport participation in youth with congenital

Pediatric Heart Network Investigators: Rationale and

after the Norwood procedure. Journal of Thoracic

heart disease: perceptions of children and parents.

design of a randomized clinical trial of beta-blocker

Cardiovascular Surgery 2008: 135(1): pp 83-90.

Adapted Physical Activity Quarterly 2008: 25: pp 49-70.

therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan

McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM,

Nelken J, Meshkani R, Chahal N, McCrindle BW, Adeli K:

syndrome. American Heart Journal 2007: 154(4):

Takahashi M, Vetter VL, Gersony WM, Mitchell PD,

Detection of familial defective apoB (FDB) mutations in

pp 624-631.

Newburger JW, for the Pediatric Heart Network

hypercholesterolemic children and adolescents by

Investigators: Coronary artery involvement in children

denaturing high performance liquid chromatography

Li J, Zhang G, Benson L, Holtby H, Cai S, Humpl T,

with Kawasaki disease: risk factors from analysis of

(DHPLC). Clinical Biochemistry 2008: 41(6): pp 395-399.

Van Arsdell GS, Redington AN, Caldarone CA:

serial normalized measurements. Circulation 2007:

Comparison of the profiles of postoperative systemic

116(2): pp 174-179.

Nielsen JM, Kristiansen SB, Ringgaard S, Nielsen TT,

the hybrid or the Norwood procedure: a pilot study.

McCrindle BW, McIntyre S, Kim C, Lin T, Adeli K:

volume measurement in mice by conductance

Circulation 2007: 116(11 Suppl): pp 179-187.

Are patients after Kawasaki disease at increased

catheter. Evaluation and optimization of calibration.

risk for premature cardiovascular disease? Journal

American Journal of Physiology - Heart and Circulatory

of Pediatrics 2007: 151(3): pp 244-248.

Physiology 2007: 293(1): H534-H540.

Flyvbjerg A, Redington AN, Botker HE: Left ventricular

hemodynamics and oxygen transport in neonates after

20 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Roche SL, Kaufman J, Dipchand AI, Kantor PF:

Osaki M, Caldarone CA, Dipchand AI: Extended aortic

Pollock-BarZiv SM, McCrindle BW, West LJ,

dissection following aortic cannulation in an infant.

Dipchand AI: Waiting before birth: outcomes after

Hypertension after pediatric heart transplantation is

Pediatric Cardiology 2008: 29: pp 232-233.

fetal listing for heart transplantation. American

primarily associated with immunosuppressive regimen.

Journal of Transplantation 2008: 8: pp 412-418.

The Journal of Heart and Lung Transplantation 2008: 5: pp 501-507.

Osaki M, McCrindle BW, Van Arsdell GS, Dipchand AI: Anomalous origin of a coronary artery from the

Pollock-BarZiv SM, McCrindle BW, West LJ, Manhliot C,

opposite sinus of valsalva with an interarterial course:

Vanderliet M, Dipchand AI: Competing outcomes after

Roman KS, Fouron JC, Nii M, Smallhorn JF,

clinical profile and approach to management in the

neonatal and infant wait-listing for heart transplantation.

Chaturvedi R, Jaeggi ET: Determinants of outcome in

pediatric population. Pediatric Cardiology 2008:

Journal of Heart and Lung Transplantation 2007: 26:

fetal pulmonary valve stenosis or stresia with intact

29(1): pp 24-30.

pp 980-985.

ventricular septum. American Journal of Cardiology 2007: 99: pp 699-703.

Ozawa A, Chaturvedi R, Lee KY, Benson L: Femoral

Reid GJ, Siu SC, McCrindle BW, Irvine MJ, Webb GD: Saul JP, Epstein AE, Silka MJ, Berul CI, Dick M,

vein hemostasis in children using a suture-mediated

Sexual behaviour and reproductive concerns among

device. Journal of Interventional Cardiology 2007:

adolescents and young adults with congenital heart

DiMarco JP, Friedman RA, Rosenthal E, Stephenson EA,

20: pp 164-167.

disease. International Journal of Cardiology 2008:

Vetter VL: Clinical competency statement: training

125(3): pp 332-338.

pathways for implantation of cardioverter-defibrillators and cardiac resynchronization devices in pediatric

Pihkala J, Yazaki S, Mehta R, Lee KJ, Chaturvedi R, Reid GJ, Webb GD, McCrindle BW, Irvine MJ, Siu SC:

and congenital heart patients. Heart Rhythm Journal

clinical impact of transcatheter closure of interatrial

Health behaviors among adolescents and young

2008: 5(6): pp 926-933.

communications after a fenestrated Fontan

adults with congenital heart disease. Congenital

procedure: medium-term outcomes. Catheterization

Heart Disease 2008: 3(1): pp 16-25.

Soslow JH, Friedberg MK, Silverman NH. Idiopathic

Richmond ME, Addonizio LJ, Hsu DT, Mital SR, Mosca

an indication for early delivery. Echocardiography

Pollock-BarZiv SM, den Hollander N, Ngan BY,

RS, Quaegebeur JM, Chen J, Lamour, JM: Cardiac

2008: April 8 [E-pub ahead of print].

Kantor P, McCrindle BW, Dipchand AI: Pediatric heart

retransplantation in high-risk pediatric patients.

transplantation in HLA-sensitized patients: evolving

Pediatric Transplantation 2007: 11: pp 615-623.

McCrindle BW, Arsdell GV, Benson LN. Feasibility and

premature closure of the ductus arteriosus:

and Cardiovascular Intervention 2007: 69: pp 1007-1014.

Stephenson EA, Berul CI: Electrophysiologic

management and assessment of intermediate-term

interventions for inherited arrhythmia syndromes.

outcomes in a high-risk population. Circulation 2007:

Circulation 2007: 116: pp 1062-1080.

116(11 Suppl): pp 1172-1178.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 21

Suto F, Zhu W, Chan A, and Gross GJ: IKr and

Wong D, Benson LN, Van Arsdell GS, Karamlou T,

Dodd DA, Cabo J, Dipchand AI: Acute rejection:

IKs remodelling differentially affects QT interval

McCrindle BW: Balloon angioplasty is preferred

natural history, risk factors, surveillance, and

prolongation and dynamic adaptation to heart rate

to surgery for aortic coarctation. Cardiology in the

treatment. In: ISHLT Monograph Series Pediatric

acceleration in bradycardic rabbits. American Journal

Young 2008: 18: pp 79-88.

Heart Transplantation (Canter CE, Kirklin J, eds.). Philadelphia: Elsevier, 2008.

of Physiology – Heart and Circulatory Physiology 2007: 292: pp H1782-H1788.

Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Hendelman RM,

Friedberg MK, Silverman NH, Hanley FL, Mohan RV,

Vogt KN, Manlhiot C, Van Arsdell G, Russell JL, Mital

Backx PH, Redington AN, Maclennan DH, Bruneau BG:

Albanese CT: Fetal cardiac intervention. In:

S, McCrindle BW. Somatic growth in children with

Tbx5-dependent pathway regulating diastolic function in

Hemodynamics and Cardiology: Neonatology

single ventricle physiology: Impact of physiologic state.

congenital heart disease. Proceedings of the National

Questions and Controversies (Kleinman CS and

Journal of the American College of Cardiology 2007:

Academy of Science USA 2008: 105(14): pp 5519-5524.

Seri I, eds.). Philadelphia: Saunders/Elsevier, 2008.

BOOK CHAPTERS

Redington AR: Cardiopulmonary and right-left heart

50(19): pp 1876-1883. Walsh MA, Benson LN, Dipchand AI, Redington AN,

Benson L: Pulmonary vein stenosis. In: Percutaneous

interactions. In: Moss and Adam’s Heart Disease in

Caldarone CA, Van Arsdell GS, Kantor PF: Surgical

Interventions for Congenital Heart Disease (Sievert H,

Infants, Children and Adolescents (Including the Fetus

repair of the mitral valve in children with dilated

Qureshi S, Wilson N, Hijazi Z, eds.). London: Informa

and Young Adult), 7th Edition (Allen HD, Driscoll DJ,

cardiomyopathy and mitral regurgitation. Annals

Healthcare, 2007.

Shaddy RE, Feltes TF, eds.). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins, 2008.

of Thoracic Surgery 2008: 85: pp 2085-2088. Benson L, Mikailian H: Imaging modalities in the Walsh MA, Lee K-J, Chaturvedi R, Van Arsdell GS,

cath lab: angiography. In: Percutaneous Interventions

Webb GD, Smallhorn JF, Therrien J, Redington AN:

Benson LN: Radiofrequency perforation of right

for Congenital Heart Disease (Sievert H, Qureshi S,

Congenital heart disease. In: Braunwald’s Heart

ventricular outflow tract as a palliative strategy

Wilson N, Hijazi Z, eds.). London: Informa Healthcare,

Disease: A Textbook of Cardiovascular Medicine, 8th

for pulmonary atresia wiht ventricular septal defect.

2007, pp 15-32.

Edition (Libby P, Bonow RP, Mann DL, Zipes D, eds.).

Catheterization and Cardiovascular Interventions 2007: 69: pp 1015-1020.

Philadelphia: Saunders Elsevier, 2007. Dipchand AI: HSC mismatch protocol. In: Paediatric heart transplantation - en handledning for vardgivare

Yoo SJ, Jaeggi E. Ultrasound evaluation of the

(Gilljam T, ed.). Goteborg: Sahlgrenska

fetal heart. In: Ultrasonography in Obstetrics and

Universitetssjukhuset, 2008.

Gynaecology, 5th Edition (Callen P, ed.) Philadelphia: Saunders Elsevier, 2008.

22 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

FUNDING

Characterisation of circulating effectors and temporal

Contractile adaptations to constrained heart rate

A randomized, double-blind, multi-centre study of

profiling of remote ischaemic preconditioning. Redington AN,

conditions. Gross GJ, Redington AN. Canadian

antiarrhythmic medications in the treatment of infants

Callahan J, Gross G, Kharbanda R. Canadian Institutes

Institutes of Health Research ($529,180 2008-2012).

with supraventricular tachycardia (SAMIS Trial).

of Health Research ($324,951 2006-2009). Contractile and electrophysiologic adaptations

Shubhayan S, Stephenson E, Potts J, Etheridge S.

to constrained heart rate conditions. Gross GJ,

Heart and Stroke Foundation of Canada

Canadian Institutes of Health Research Team in

($444,060 2006-2010).

Childhood Obesity Research. Anderson H, Hamilton J,

Redington AN. Heart and Stroke Foundation

Parkin P, Pencharz P. Canadian Institutes of Health

of Ontario ($209,097 2006-2008).

A transatlantic network for the investigation of remote

Research ($2,452,522 2008-2013). Contribution of three-dimensional echocardiography to

ischemic preconditioning. Redington AN, McCrindle BW, Callahan J, Wilson G, Caldarone C, Kharbanda R,

Clinical and genomic responses to remote ischemic

surgery for left ventricular outflow tract obstruction

Botker HE, Neilsen TT. Leducq Foundation

preconditioning. Redington A, Arab S, Coles J, Holtby H,

in children. Friedberg MK, Van Arsdell G, Calderone C,

Liu P, Schwartz S, Van Arsdell G. National Heart, Lung,

Coles J, Golding F, Bradley TJ, Gooi A. The Hospital

($6,800,000 2006-2011). Biventricular pacing in children after surgery for

and Blood Institute/National Institutes of Health

for Sick Children Paediatric Consultants Partnership

($2,047,004 US 2006-2011).

($9,819 2007-2008).

congenital heart disease. Friedberg M, Stephenson EA. Labatt Family Heart Centre Innovations Funding

Clinical and laboratory evaluation of acute rejection,

Creating a fetal lamb model of hypoplastic left heart

($15,000 2007-2009).

myocyte growth, repair and oxidative stress following

syndrome. Chaturvedi R, Jaeggi E. Labatt Family

de novo cardiac transplant: a comparison between

Heart Centre ($21,000 2008).

Cardiac gene bank. Mital S, Hamilton R, Coles J.

tacrolimus- and cyclosporine-based immunprophylactic

Labatt Heart Centre Fund ($100,000 2008-2010).

regimens with mycophenolic acid therapeutic drug

CTOT-C (Clinical Trials in Organ Transplantation

monitoring. Dipchand AI, Pollock BarZiv S, Allain-

in Children) 1U01AI077867-01: Alloantibodies in

Cardiac transplantation in infancy – exploring the

Rooney T, Kantor PF. Astellas Pharma Canada Inc.

cardiac transplantation: Intervention, outcomes

implication for the immune system. Platt J, West L,

($65,000 2006-2008).

and mechanisms. Webber S, Dipchand AI, Blume E, Canter C, Naftel D, Hsu D. National Institutes of

Cascalho M. National Heart, Lung, and Blood Institute/National Institutes of Health

Clinial characteristics and psychological health

($7,100,942 US 2005-2010).

of Canadian children with implantable cardioverter

Health ($5,205,958 2008-2013).

defibrillators. Stephenson EA, Conway J, Chiu-Man C, Mendlowitz S. Labatt Family Heart Centre Innovations Funding ($10,731 2008-2009).

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 23

Identifying factors involved in the prenatal diagnosis

Individualized heparin and protamine management

Late functional status in a cohort of survivors with

of congenital heart defects requiring neonatal

in infants undergoing cardiopulmonary bypass

pulmonary atresia intact ventricular septum from the

intervention. Dutil N, Jaeggi E. Labatt Family Heart

for cardiac surgery reduces bleeding and blood

Congenital Heart Surgeons Society study. Caldarone C.

transfusion requirements. Guenwald C, Chan A,

Children’s Heart Foundation ($89,190 US 2007-2008).

Centre ($18,600 2008-2009).

Van Arsdell G, Holtby H. Heart and Stroke Effects of remote ischemic preconditioning on clinical

Foundation of Canada ($108,566 2006-2008).

Molecular expression and physiology in developing atrioventricular nodal cells. Hamilton RM, Gross GJ,

and genomic responses to open heart surgery in children. McCrindle BW, Redington A. Canadian

Inflammation and atherosclerosis in paediatric

Silverman ED. Canadian Institutes of Health

Insititutes of Health Research ($100,000 2007-2008).

rheumatic disease. Bradley TJ, Beyene J, Schneider R,

Research ($370,500 2006-2009).

Effects of right ventricular intraventricular mechanical

Centre - Innovation Fund ($12,000 2007-2008).

Feldman B, Silverman ED. Labatt Family Heart Optimizing health among children with congenital heart defects through rehabilitation focused on physical

dyssynchrony on right and left ventricular dysfunction

activity determinants. McCrindle BW, Russell JL,

in tetralogy of Fallot. Friedberg M, Redington A,

Inflammation and atherosclerosis in paediatric

Yoo S-J, Stephenson E, Russell J, Kantor P, Roche L.

rheumatic disease. Bradley TJ, Beyene J, Schneider R,

Dettmer E, Longmuir P. Heart and Stroke Foundation

National Grants Program, SickKids Foundation,

Feldman B, Silverman ED. Heart and Stroke

of Canada ($208,928 2007; $616,465 2008-2011).

and Canadian Institutes of Health Research

Foundation of Ontario ($125,448 2007-2009). Outcome of paediatric patients with cardiomyopathy:

($108,766 2007-2009). Intercalated disc potein expression in arrhythmogenic

a multicentre review of paediatric patients listed for

Genetics of heart disease in children. Mital S.

right ventricular cardiomyopathy. Hamilton RM,

transplant in the paediatric Heart Transplant Study

Labatt Family Heart Centre Innovation Fund

Chauhan V, Scherer S. Heart and Sroke

Group. Dipchand AI, Hsu D, Naftel D. Children’s

($200,000 per year 2007-2010).

Foundation of Ontario ($72,100 2008-2010).

Cardiomyopathy Foundation ($21,321 2007-2008).

HLA sensitization: prevalence and impact of

Intrauterine growth retardation associated with and

Perioperative use of thymoglobulin in paediatric heart

alloantibodies in paediatric heart transplant recipients.

without placental insufficiency: impact on myocardial

transplant recipients. Dipchand AI, Pollock-BarZiv SM,

Dipchand AI, Pollock-Barziv S, McCrindle BM. The

function and on arterial compliance. Jaeggi ET,

Allain-Rooney T, Kantor PF. Genzyme Canada ($5,000

Hospital for Sick Children Paediatric Consultants

Bradley TJ, Keating SJ, Kingdom JCP. Heart and

2006-2007).

Partnership ($10,000 2007 - 2008).

Stroke Foundation of Ontario ($77,255 2006-2008).

24 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Prevention, detection and management of

Temporal profiling and circulating effectors of remote

Validation of accelerometry as a measure of physical

thromboembolic complications after paediatric cardiac

ischaemic preconditioning. Redington A, Callahan J.

activity and inactivity in children with chronic disease.

surgery: toward evidence-based clinical protocols.

Canadian Institutes of Health Research ($284,000

Feldman B, Stephens S, Takken T, Wright V, Tremblay M,

Manlhiot C, Gruenwald C, Brandao L, Chan AK,

2005-2008).

Eslinger D, Beyene J, Walker-Schneiderman J, Biggar W, Longmuir P, Vandernet J. Canadian Institutes of

Schwartz S, Holtby H, Sivarajan B, Van Arsdell G, Caldarone C, Clarizia N, Crawford-Lean L. Labatt

The effect of remote ischemic preconditioning on

Family Heart Centre Innovations Fund ($29,210 2008).

clinical and genetic responses to open heart surgery

Right ventricular versus modified blalock-taussig shunt

Health Research ($65,000 2007-2008).

in children. Redington A. Canadian Institutes of

Ventricular function and arterial stiffness in the

Health Research ($97,360 2007-2008).

evaluation of paediatric heart failure. Kantor PF, Bradley TJ, Roche SL, Slorach C. The Hospital

in infants with single ventricle defect undergoing staged reconstruction. McCrindle BM, Site PI, in a

The effectiveness of low fat breast milk for the

for Sick Children Paediatric Consultants

multicentre networked collaboration. National Heart,

treatment of chylothorax in infants following

Partnership ($7,200 2007-2008).

Lung, and Blood Institute/National Institutes of

cardiothoracic surgery: a pilot study. Farmer S, Russell

Health ($300,000 2005-2008).

JL, O’Connor D. Labatt Heart Centre Innovation Fund

Ventricular repolarization in complete heart block.

($24,000 2007).

Gross GJ. Heart and Stroke Foundation of Ontario ($208,406 2004-2007).

Role of chronic inflammation and systemic lupus erythematosus-related factors in the development

The role of traditional and non-traditional risks in the

of premature atherosclerosis in paediatric SLE.

development of atherosclerosis in paediatric systemic

Silverman ED, Bargman JM, Beyene J, Bradley TJ. Heart

lupus erythematosus. Silverman E, Adeli K, Bargman J.

remodelling. Gross GJ. Heart and Stroke Foundation

and Stroke Foundation of Ontario ($275,000 2006-2009).

Heart and Stroke Foundation of Ontario ($163,454

of Ontario ($268,447 2007-2010).

Ventricular repolarization in bradycardic electrical

2003-2008). Very high resolution vascular imaging in children

RSV immunoprophylaxis in children with congenital heart disease. Lee K-J, Cranis M, Allen U, James A,

The SAMIS Trial: multicentre study of antiarrhythmic

with normal and abnormal vascular development

O’Brien K, Simmons B, Dennis M, Bracht M, O’Doherty B.

medications for treatment of infants with supraventricular

and maturation. Sarkola T, Jaeggi E, Redington A.

Abbott Laboratories ($71,482 2006-2007).

tachycardia. Sanatani, S, Stephenson EA, McCrindle BM,

Societatis Medicorum Fennicae (£20,000 salary

Potts J, Etheridge S. Heart and Stroke Foundation of

support for Dr. Sarkola) Instrumentarium Foundation

British Columbia and Yukon ($440,060 2006-2010).

(£50,000); The Finnish Cultural Foundation £20,000)

RSV immunoprophylaxis in children with congenital heart disease. Lee K-J, Cranis M, Allen U, James A,

(2008-2009).

O’Brien K, Simmons B, Dennis M, Bracht M, O’Doherty B. Abbott Industries ($82,217 2007-2008).

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 25

Dr. Rosanna Weksberg

DIVISION HEAD Dr. Rosanna Weksberg FULL-TIME Dr. David Chitayat Dr. Annette Feigenbaum

Dr. Roberto Mendoza Dr. Julian Raiman Dr. Andreas Schulze Dr. Grace Yoon

PART-TIME Dr. Karen Chong Dr. Joe Clarke Dr. Leona Fishman Dr. Stephen Meyn Dr. Ahmad Teebi

CLINICAL FELLOWS Dr. Fatma Al-Jasmi Dr. Fathiya Al-Murshedi Dr. Christopher Barnett Dr. Brian Chung

Dr. Ellen Crushell Dr. Arie Koifman Dr. Gustavo Maegawa Dr. Sandhya Parkash

RESIDENTS Dr. Hanna Faghfoury Dr. Jane Gillis Dr. Elaine Goh Dr. Sharan Goobie

Division of Clinical and Metabolical Genetics OVERVIEW

newborn period. SickKids is one of five regional

established to honour Dr. Opitz, the founding

The Division of Clinical and Metabolic Genetics

newborn screening centres and is the largest in the

editor-in-chief of the American Journal of Medical

provides excellent clinical care, and supports a variety

province. Dr. Andreas Schulze was recently appointed

Genetics. The awardee is selected for a significant

of clinical, research, educational and administrative

the Medical Director of the Newborn Screening

research paper published in the previous year in the

programs. An important new endeavour is the Ontario

Program. The program at SickKids is co-ordinated with

American Journal of Medical Genetics in the areas of

Genetics Secretariat (OGS). The Secretariat was

the Division of Clinical and Metabolic Genetics and is

congenital anomalies, mechanisms of morphogenesis

generated by a Department of Paediatrics invitation

supported by an interdisciplinary team.

and malformations, or developmental biology.

The support of this initiative by CHS and the Hospital

Research endeavors in the division are a vital part of

The seventh annual Starbucks Clinical Research

to support province-wide subspecialty initiatives. Executive has been instrumental in its success.

our program and currently focus on the translation of

Summer Students Competition was awarded to

The OGS is chaired by Christopher Carew from

new genomic information for patients and their families.

Laura White for a study on bone marrow transplantation

SickKids and has representation from all the clinical

The use of microarrays for genetic testing continues to

in Mucopolysaccaridosis type I (Hurler Disease). She was supervised by Dr. Julian Raiman.

genetics programs and genetic diagnostic laboratories

increase.The large influx of genomic data for many of

across Ontario. The mandate of OGS is to develop a

our patients has impacted our pattern of practice.

collaborative and integrated approach to negotiations

There are many new challenges in the interpretation of

with the Ontario Ministry of Health and Long-Term

entirely novel data in the clinical setting.

developed and participated in numerous educational activities within the hospital. It has important links to

Care for resourcing genetic services. The DNA Resource Centre Program has continued to

The Division of Clinical and Metabolic Genetics has

Dr. Grace Yoon received the John M. Opitz Young

the Research Institute and the Department of Paediatric

Investigator Award in the fall of 2007. This award was

Laboratory Medicine. The division directs fellowship

provide up-to-date information regarding genetic testing available nationally and internationally, and ensures that all patients at SickKids have access to cutting-edge genetic testing.

Drs. Roberto Mendoza, David Chitayat and team In 2006, the MOHLTC embarked on major changes to newborn screening. Twenty-six additional disorders (endocrine, genetic metabolic, hemoglobinopathies and cystic fibrosis) are now screened for in the

RESIDENTS Dr. Shailly Jain Dr. Linda Kim Dr. Joyce So Dr. Mohammad Yaghoobi

ADMINISTRATIVE STAFF Jennifer Costa Michael Delaney Susan Dukhedlin-Lalla

Laurie Furtado Kamalina Gupta Denese Henry Andrea Jonker

Melanie Lameront Tina McConkey Natalie Sargeant Deb Taylor Rozmin Visram

and residency training programs in genetic medicine

Briggs TA, Abdel-Salam GM, Balicki M, Baxter P,

Demuth I, Bradshaw PS, Lindner A, Anders M,

as well as the MSc Program in Genetic Counselling.

Bertini E, Bishop N, Browne BH, Chitayat D,

Heinrich S, Kallenbach J, Schmelz K, Digweed M,

Chong WK, Eid MM, Halliday W, Hughes I,

Meyn MS, Concannon P: Endogenous hSM1B/Apollo

HONOURS AND AWARDS

Klusmann-Koy A, Kurian M, Nischal KK, Rice GI,

interacts with TRF2 and stimulates ATM in response

Yoon G: John M. Opitz Young Investigator Award, 2007.

Stephenson JB, Surtees R, Talbot JF, Tehrani NN,

to ionizing radiation. DNA Repair 2008: May 9

Tolmie JL, Toomes C, van der Knaap MS, Crow YJ:

[Epub ahead of print].

PUBLICATIONS

Cerebroretinal microangiopathy with calcifications

Auray-Blais C, Cyr D, Ntwari A, West ML,

and cysts (CRMCC). American Journal of Medical

Footitt EJ, Sinha MD, Raiman JA, Dhawan A,

Cox-Brinkman J, Bichet DG, Germain DP,

Genetics, Part A 2008: 146(2): pp 182-190.

Moganasundram S, Champion MP: Mitochondrial

Clarke JTR, Drouin R: Urinary globotriaosylceramide

Brunetti-Pierri N, Doty SB, Hicks J, Phan K,

and review. British Journal of Anaethesia 2008:

excretion correlates with the genotype in children

Mendoza-Londono R, Blazo M, Tran A, Carter S,

100(4): pp 436-441.

disorders and general anaesthesia: a case series

Laframboise R, Melançon SB, Stockley T,

and adults with Fabry disease. Molecular Genetics

Lewis R, Plon S, Phillips W, Smith EO, Ellis K, Lee, B:

and Metabolism 2008: 93: pp 331-340.

Generalized metabolic bone disease in Neurofibromatosis

Greer KJ, Kirkpatrick SJ, Weksberg R, Pauli RM:

type 1. Molecular Genetics and Metabolism 2008:

Beckwith-Wiedemann syndrome in adults:

94(1): pp 105-111.

observations from one family and recommendations

Bähring S, Kann M, Neuenfeld Y, Gong M, Chitayat D,

for care. American Journal of Medical Genetics.

Toka HR, Toka O, Plessis G, Maass P, Rauch A, Aydin A, Luft FC: Inversion region for hypertension and

Clarke JTR, West M, Bultas J, Schiffmann R: The

Part A 2008: 146A(13): pp 1707-1712.

brachydactyly on chromosome 12p features multiple

pharmacology of multiple regimens of agalsidase

splicing and noncoding RNA. Hypertension 2008:

alfa enzyme replacement therapy for Fabry disease.

Hadzi N, Vara R, Raiman J, Mieli-Vergani G:

51(2): pp 426-431.

Genetic Medicine 2007: 9: pp 504-509.

Old versus new antiepileptic drugs: The SANAD study. Lancet 2007: 370(9584): p 315.

Beauchamp NJ, Dalton A, Ramaswami U, Niinikoski H, Mention K, Kenny P, Kolho KL, Raiman J, Walter J, Treacy E, Tanner S, Sharrard M: Glycogen storage disease type IX: high variability in clinical phenotype. Molecular Genetics and Metabolism 2007: 92(1-2): pp 88-99.

28 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ:

Lindner M, Abdoh G, Fang-Hoffmann J, Shabeck N,

McCready ME, Carson NL, Chakraborty P, Clarke JT,

Prenatal diagnosis of topsy-turvy heart. Cardiology

Al-Sayrafi M, Al-Janahi M, Ho S, Abdelrahman MO,

Callahan JW, Skomorowski MA, Chan AK, Bamforth F,

in the Young 2008: 18(3): pp 337-342.

Ben-Omran T, Bener A, Schulze A, Al-Rifai H, Al-Thani G,

Casey R, Rupar CA, Geraghty MT: Development of a

Hoffmann GF: Implementation of extended neonatal

clinical assay for detection of GAA mutations and

Kepron C, Blumenthal A, Chitayat D, Cutz E,

screening and a metabolic unit in the State of Qatar:

characterization of the GAA mutation spectrum in a

Superti-Furga A, Keating S. An autophagic vacuolar

developing and optimizing strategies in co-operation

Canadian cohort of individuals with glycogen storage

myopathy-like disorder presenting as non-immune

with the Neonatal Screening Center in Heidelberg.

disease, type II. Molecular Genetics and Metabolism

hydrops in a female fetus. Pediatric and Developmental

Journal of Inherited Metabolic Disease 2007: 30(4):

2007: 92: pp 325-335.

Pathology 2008: February 25 [Epub ahead of print].

pp 522-529.

Konen O, Armstrong D, Clarke H, Padfield N,

Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L,

Napierala D, Scott DA, Sibai T, Casas K, Wilson P,

Weksberg R, Blaser S: C1-2 vertebral anomalies

Skaug J, Shago M, Moessner R, Pinto D, McAuliffee F,

Lee J, Muneer R, Leonard JC, Ramji FG, Lachman R,

in 22q11.2 microdeletion syndrome. Pediatric

Chitayat D, Halliday W, Keating S, Shah V,

Li S, Stankiewicz P, Lee B, Mulvihill JJ: De novo

Radiology 2008: 38(7): pp 766-771.

Fink M, Nevo O, Ryan G, Shannon P, Blaser S:

three-way chromosome translocation 46, XY, t

Rhombencephalosynapsis: prenatal imaging and

(4;6;21)(p 16; p 21.1; q21) in a male with

Levy HL, Milanowski A, Chakrapani A, Cleary M,

autopsy findings. Ultrasound in Obstetrics and

cleidocranial dysplasia. American Journal of Medical

Lee P, Trefz FK, Whitley CB, Feillet F, Feigenbaum AS,

Gynaecology 2008: 3(5): pp 542-548.

Genetics 2008: 146(4): pp 453-8.

Purandare SM, Mendoza-Londono R, Yatsenko SA,

Bebchuk JD, Christ-Schmidt H, Dorenbaum A, Sapropterin Research Group: Efficacy of sapropterin

Marshall C, Noor A, Vincent J, Lionel A, Feuk L,

Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S,

dihydrochloride (tetrahydrobiopterin, 6R-BH4) for

Skaug J, Shago M, Moessner R, Pinto D, Ren Y,

Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C,

reduction of phenylalanine concentration in patients

Thiruvahindrapduram B, Fiebig A, Schreiber S,

Kirkpatrick S, Nicolson R, Sloman L, Summers A,

with phenylketonuria: a phase III randomised

Friedman J, Ketelaars CEJ, Vos YJ, Ficicioglu C,

Gibbons CA, Teebi A, Chitayat D, Weksberg R,

placebo-controlled study. Lancet 2007: 370(9586):

Kirkpatrick S, Nicholson R, Sloman L, Summers A,

Thompson A, Vardy C, Crosbie V, Luscombe S,

pp 504-510.

Gibbons C, Teebi A, Chitayat D, Weksberg R,

Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B,

Thompson A, Vardy C, Crosbie V, Luscombe S,

Szatmari P, Scherer SW: Structural variation of

Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B,

chromosomes in autism spectrum disorder. American

Szatmari P, Scherer S: Structural variation of

Journal of Human Genetics 2008: 82(2): pp 477-488.

chromosomes in autism spectrum disorder. American Journal of Human Genetics 2008: 82(2): pp 477-488.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 29

Spitzer RF, Wherrett D, Chitayat D, Colgan T, Dodge JE,

Robinson AJ, Blaser S, Toi A, Chitayat D, Halliday W,

Sermer D, Quercia N, Chong K, Chitayat D: Acrofacial

Pantazi S, Gundogan M, Laughlin S, Ryan G: The fetal

dysostosis syndrome type Rodriguez: prenatal diagnosis

Salle JL, Allen L: Maternal luteoma of pregnancy

cerebellar vermis: assessment for abnormal development

and autopsy findings. American Journal of Medical

presenting with virilization of the female infant.

by ultrasonography and magnetic resonance imaging.

Genetics. Part A 2007: 143(24): pp 3286-3289.

Journal of Obstetrics and Gynaecology Canada 2007: 29(10): pp 835-840.

Ultrasound Quarterly 2007: 23(3): pp 211-223. Smith AC, Shuman C, Chitayat D, Steele L, Ray PN, Rela M, Battula N, Madanur M, Mieli-Vergani G,

Bourgeois J, Weksberg R: Severe presentation of

Stachon AC, Baskin B, Smith AC, Shugar A,

Dhawan A, Champion M, Raiman J, Heaton N: Auxiliary

Beckwith-Wiedemann syndrome associated with high

Cytrynbaum C, Fishman L, Mendoza-Londono R,

liver transplantation for propionic academia. American

levels of constitutional paternal uniparental disomy for

Klatt R, Tebbi A, Ray PN, Weksberg R: Molecular

Journal of Transplantation 2007: 7(9): pp 2200-2203.

chromosome 11p15. American Journal of Medical

diagnosis of 22q11.2 deletion and duplication by

Genetics. Part A 2007: 143(24): pp 3010-3015.

multiplex ligation dependent probe amplification. American Journal of Medical Genetics. Part A 2007:

Revencu N, Boon LM, Mulliken JB, Enjolras O, Crodisco MR, Burrows PE, Clapuyt P, Hammer F,

Smith AC, Choufani S, Ferreira JC, and Weksberg R:

Dubois J, Baselga E, Brancati F, Carder R, Quintal JM,

Growth regulation, imprinted genes and chromosome

Dallapiccola B, Fischer G, Frieden IJ, Garzon M, Harper J,

11p15.5. Pediatric Research 2007: 61(5 Pt 2):

Johnson-Patel J, Labreze C, Martorell L, Paltiel HJ, Pohl

pp 43R-47R.

143(23): pp 2924-2930. Van der Knaap MS, Linnankivi T, Paetau A, Feigenbaum A, Wakusawa K, Haginoya K, Kohler W, Henneke M, Dinopoulos A, Grattan-Smith P, Brockmann K,

A, Prendiville J, Rohrbach M, Clarke JTR: Treatment of lysosomal storage disorders: progress with enzyme

Somech R, Somers GR, Chitayat D, Grunebaum E,

Schiffmann R, Blaser S: Hypomyelination with atrophy

replacement therapy. Drugs 2007: 67: pp 2697-2716.

Atkinson A, Kolomietz E, Roifman CM: Fatal lung

of the basal ganglia and cerebellum. Follow-up and

fibrosis associated with immunodeficiency and

pathology. Neurology 2007: 69: pp 166-171.

Quere I, Siegel DH, Valente EM, Van Hagen A, Van

gonadal dysgenesis in 46XX sisters – a new syndrome.

Hest L, Vaux KK, Vicente A, Weibel L, Chitayat D,

American Journal of Medical Genetics. Part A 2008:

Verbruggen KT, Sijens PE, Schulze A, Lunsing RJ,

Vikkula M: Parkes Weber syndrome, vein of Galen

146(1): pp 8-14.

Jakobs C, Salomons GS, van Spronsen FJ. Successful

aneurysmal malformation, and other fast-flow vascular

treatment of a guanidinoacetate methyltransferase

anomalies are caused by RASA1 mutations. Human

deficient patient: findings with relevance to treatment

Mutations 2008: 29(7): pp 959-965.

strategy and pathophysiology. Molecular Genetics and Metabolism 2007: 91(3): pp 294-296.

30 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Watts P, Kumar N, Ganesh A, Sastry P, Pilz D, Levin AV,

Yoon G, Westmacott R, MacMillan L, Quercia N,

Hughes S, Weksberg R, Moldovan L: Use of

Chitayat D: Chorioretinal dysplasia, hydranencephaly,

Koutsou P, Georghiou A, Christodoulou K, Banwell B:

quantitative PCR for the detection of genomic

and intracranial calcifications: pseudo-TORCH or a

Complete deletion of the aprataxin gene: ataxia with

microdeletions or microduplications. In: PCR

new syndrome? Eye 2008: 22(5): pp 730-733.

oculomotor apraxia type 1 with severe phenotype and

Methods Express (Hughes S, Moody A, eds.).

cognitive deficit. Journal of Neurology, Neurosurgery

Scion Publishing Ltd., United Kingdom, 2007.

Weksberg R, Shuman C, Wilkins-Haug L, Mann M,

and Psychiatry 2008: 79(2): pp 234-236.

Stewart D, Croughan M, Rakowsky C, Leader A, Hall J,

Mendoza-Londono R, Ardelean D, Goobie S:

Friedman JM, Simpson JL, Holmes L, Infante-Rivard C:

Zampino G, Pantaleoni F, Carta C, Cobellis G, Vasta I,

Genetics: In: The Hospital for Sick Children

Workshop report: evaluation of genetic and epigenetic

Neri C, Pogna E, De Feo E, Delogu A, Sarkozy A, Atzeri F,

Handbook of Paediatrics. Elsevier, Canada, 2007.

risks associated with assisted reproductive

Selicorni A, Rauen K, Cytrynbaum C, Weksberg R,

technologies and infertility. Fertility and Sterility 2007:

Dallapiccola B, Ballabio A, Gelb B, Neri G, Tartaglia M:

Schulze A, Battini R: Pre-symptomatic treatment

88(1): pp 27-31.

Diversity, parental germline origin, and phenotypic

of Creatine biosynthesis defects. In: Creatine and

spectrum of de nova HRAS missense changes in Costello

creatine Kinase in Health and Disease (Salomons

syndrome. Human Mutation 2007: 28(3): pp 265-272.

GS, Wyss M, eds.). Springer, Dordrecht, 2007.

Werner T, Treiss I, Kohlmueller D, Mehlem P, Teich M, Longin E, Gerstner T, Koenig SA, Schulze A: Effects of valproate on acylcarnitines in children with epilepsy

BOOKS AND BOOK CHAPTERS

Wyss M, Braissant O, Pischel I, Salomons GS,

using ESI-MS/MS. Epilepsia 2007: 48(1): pp 72-76.

Chitayat D: The clinical approach to the newborn with

Schulze A, Stockler S, Wallimann T: Creatine and

multiple abnormalities. In: Residents Handbook of

creatine kinase in health and disease - a bright future

Yoon G, Rosenberg J, Blaser S, Rauen KA:

Neonatology, 3rd Edition (Kirpalani H, Moore A,

ahead? In: Creatine and Creatine Kinase in Health

Neurological complications of the cardio-facio-

Perlman M, eds.). B.C. Decker Inc., Hamilton, Ontario,

and Disease (Salomons GS, Wyss M, eds.). Springer,

cutaneous syndrome (CFC). Developmental Medicine

Canada, 2007.

Dordrecht, 2007.

and Child Neurology 2007: 49(12): pp 894–899.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 31

FUNDING

Canadian Molecular Cytogenetics Platform.

Gene expression of neuronal progenitors in a

Analysis of imprinting control in a tumour predisposing

Friedman JM, Chitayat D, Meyn S, Weksberg R.

1q22-linked familial subtype of schizophrenia.

region on human chromosome 11p15. Weksberg R,

Canadian Foundation for Innovation ($4,512,925

McCurdy R, Weksberg R. Canadian Psychiatric

Squire J. Canadian Institutes of Health Research

2005-2010)

Research Foundation (CPRF) ($80,000 2005-2007)

Collaborative Graduate Training Program in Molecular

Genome-wide DNA methylation profiling in autism.

Autism: Searching for epigenetics errors. Weksberg R.

Medicine (training grant) Canadian Institutes of

Weksberg R, Roberts W, Scherer S. Canadian

SickKids Foundation New Ideas Grant ($50,000

Health Research ($300,000 2002-2008)

Institutes of Health Research ($649,518 2008-2011)

Dynamics of human double-strand break repair.

Hunter Outcome Survey. Clarke, J. Shire Human

($359,565 2004-2007)

2007-2008) A retrospective natural history study of ASM deficiency

Meyn S. Canadian Institutes of Health Research

Genetic Therapies ($560 per patient ID entry

(Niemann-Pick Disease Types A and B). Clarke J.

($123,000 2004-2008)

2007-2009)

Genzyme Corporation ($26,995 2005-2008) Canadian Fabry Disease Initiative (combined adult

Fabry Outcome Survey. Clarke J. Shire Human Genetic

Iduronate-2-sulfatase enzyme replacement therapy in

Therapies ($110,000 2007-2009)

mucopolysaccharidosis II (MPS II). Clarke J. Shire Human Genetics Therapies ($111,497 2005-2008)

and paediatric patients). Sirrs S, Casey R, Clarke J, Bichet D, West M. Canadian federal and provincial

Formation and evaluation of a comprehensive

governments, private stakeholders ($2,967,450

computer-based teaching module concerning the

2006-2009)

Integrative genomics for health research. Scherer S,

recognition, diagnosis, and treatment of MPS II (Hunter

Weksberg R. Canadian Foundation for Innovation

disease). Clarke J, Al-Jasmi F, Moldovan L. Shire

($3,600,262 2004-2008)

Human Genetics Therapies ($149,491 2007- 2008)

32 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Investigation of intrauterine growth restriction by gene

Pregnancy and development outcomes. Weksberg R,

expression and DNA methylation profiling. Weksberg R,

Goobie S, Kim L, Roberts W, Croughan M. The

Chitayat D, Kingdom J, Keating S. Canadian Institutes

Physicians Services Incorporated Foundation

of Health Research ($383,883 2008-2011)

($20,000 2007-2008)

MPS I and other lysosomal diseases registry. Clarke J.

Rare Diseases Clinical Research Centre for urea

Genzyme Corporation ($224,901 2006-2009)

cycle disorders. Clarke J, Feigenbaum A. Canadian Institutes of Health Research ($25,000 2006-2008)

Potential predictor of schizophrenia in a genetic high-risk sample: Ontario project. Chow E, Bassett A,

Selective killing of ALT-dependent malignant cells by

Weksberg R, Zipursky R, Mikulis D. Ontario Mental

inhibition of the Fanconi anaemia pathway: a pilot

Health Foundation, Bill Jefferies Schizophrenia

study. Meyn S. The Hospital for Sick Children

Endowment Fund ($148,188 2002-2008)

Research Institute Seed Grant ($50,000 2008-2009) Urea Cycle Diseases Consortium: longitudinal study of urea cycle disorders. Feigenbaum A. Mendel Tuchman/Mark Batshaw USA ($7,000 2007-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 33

Dr. Gideon Koren

Dr. Irena Nulman

DIVISION HEAD Dr. Shinya Ito

Dr. Irena Nulman Dr. Margaret Thompson

SCIENTIFIC STAFF Dr. Patricia Harper

FULL-TIME Dr. Gideon Koren Dr. Christine Newman

PART-TIME Dr. David Juurlink

CROSS-APPOINTEES/ CLINICAL Dr. Christopher Parshuram Dr. Denis Scolnik

Dr. Dr. Dr. Dr. Dr. Dr.

Neil Shear Ran Goldman Sheila Jacobson Sylvain Baruchel Marco Sivilotti Prashant Joshi

CROSS-APPOINTEES/ SCIENTIFIC Dr. Lidia Derewlany Dr. Tom Einarson Dr. Anna Taddio Dr. Bonnie Stevens

CLINICAL FELLOWS Dr. Nobuko Taguchi Dr. Radinka Boskovic Dr. Yaron Finkelstein Dr. Tali Finkelstein Dr. Facundo Garcia Bournissen

Division of Clinical Pharmacology & Toxicology OVERVIEW

The division is one of the two major training sites of

PUBLICATIONS

The Division of Clinical Pharmacology & Toxicology

the Royal College-accredited Clinical Pharmacology

Avner M, Finkelstein Y, Hackam D, Koren G:

focusses on a wide range of drug-related issues in

Residency Program of the University of Toronto. Our

Establishing causality in pediatric adverse drug

paediatrics. The division is one of the largest and one

medical residency training program spearheaded the

reactions: use of the Naranjo probability scale.

of the most active paediatric pharmacology programs

recent change of the specialty residency training

Paediatric Drugs 2007: 9: pp 267-270.

internationally. Our major clinical activities include

structure to add Emergency Medicine to the existing

a consultation service, the Motherisk program, the

four entry disciplines, which include Paediatrics. This

Bar-Oz B, Einarson T, Einarson A, Boskovic R,

Ontario Regional Poison Information Centre, and the

change enables us to train residents with emergency

O’Brien L, Malm H, Berard A, Koren G: Paroxetine

DART (Drug Allergy, Reactions and Toxicity) clinic in

medicine background in the clinical toxicology stream

and congenital malformation: meta-analysis and

collaboration with the Division of Immunology/Allergy

of our education program.

consideration of potential confounding factors.

which provides specialized outpatient follow up and

Clinical Therapeutics 2007: 29: pp 918-926.

management for those with various drug/toxin-related

Our research programs focus on drug metabolizing

problems. The two toxicology information centres

enzymes and their regulation, drug transporters,

Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR:

receive annually about 35,000 (Motherisk) and

placental and mammary gland drug transport and

Depression during pregnancy: overview of clinical

75,000 (Poison Information Centre) inquiries which

metabolism, and reproductive toxicology and

factors. Clinical Drug Investigation 2007: 24: pp 157-179.

have reached the limit of the response capacity of

teratology, including fetal alcohol syndrome research.

the systems. The Motherisk program, directed by

The breadth and depth of these research programs

Berard A, Azoulay L, Koren G, Blais L, Perreault S,

Dr. Gideon Koren, continues disseminating new

are shown in the publication and funding records.

Oraichi D: Isotretinoin, pregnancies, abortions and

breastfeeding babies. The Ontario Regional Poison

HONOURS AND AWARDS

Journal of Clinical Pharmacology 2007: 63: pp 196-205.

Information Centre led by Dr. Margaret Thompson

Koren G: Spirit of the Community Humanitarian Award,

has now become a hub for medical toxicology training,

Toronto, 2007.

Bozzo P, Koren G, Nava-Ocampo AA, Einarson A: The

internationally. The Palliative and Bereavement Care

Koren G: Canadian Society for Clinical Pharmacology,

a comparison between depressed women treated with

Service directed by Dr. Christine Newman has recently

Education Award, 2007.

antidepressants and non-depressed women. Clinical

knowledge in the field of drug safety for fetus and

birth defects: a population-based perspective. British

attracting many residents and fellows nationally and

incidence of nausea and vomiting of pregnancy (NVP):

become a part of the division and provides expertise specifically on drug therapy for terminally ill patients.

and Investigative Medicine 2007: 29: pp 347-350. Koren G: Schwartz-Riesman Visiting Professorship, Tel Aviv University, 2007.

CLINICAL FELLOWS Dr. Parvaneh Yazdanibrojeni Dr. Miho Inoue Dr. Toshihiro Tanaka Dr. Saskia de-Wildt Dr. Dan Rhodes

Dr. Dr. Dr. Dr.

Arthur Staroselsky Alla Osadchy Aleksey Kazmin Chagit Klieger-Grossman

RESEARCH FELLOWS Dr. Alejandro A. Nava-Ocampo Dr. Shin-ichiro Takahashi Dr. Nada Djokanovic Dr. Naziha Mahmoud

RESEARCH ASSOCIATE Katarina Aleksa RESIDENT Dr. Lisa Thurgur

ADMINISTRATIVE STAFF Niki Balamatsis Hila Halshtok Leah Moscato Sarah Bondy Donna Tedesco

Chambers C, Koren G, Tutuncu ZN, Johnson D,

de Wildt SN, Koren G: Authors’ reply. Paediatric

Einarson TR, Koren G, Einarson A: Problems with

Jones KL: Are new agents used to treat rheumatoid

Anaesthesia 2008: 18: pp 273-274.

maternal antidepressant treatment and neonatal outcomes study. Archives of General Psychiatry

arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.

Dubnov-Raz G, Finkelstein Y, Koren G: Omega-3 fatty

Canadian Family Physician 2007: 53: pp 409-412.

acid supplementation during pregnancy: For mother, baby, or neither? Canadian Family Physician 2007: 53:

Chen N, Aleksa K, Woodland C, Rieder M, Koren G:

pp 817-818.

2007: 64: p 866. Einarson TR, Navioz Y, Maltepe C, Einarson A, Koren G: Existence and severity of nausea and vomiting in pregnancy (NVP) with different partners. Journal of

N-Acetylcysteine prevents ifosfamide-induced

Obstetrics and Gynaecology 2007: 27: pp 360-362.

nephrotoxicity in rats. British Journal of

Dugoua JJ, Perri D, Seely D, Mills E, Koren G:

Pharmacology 2008: 153: pp 1364-1372.

Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation.

Etwel FA, Rieder MJ, Bend JR, Koren G:

Chen N, Aleksa K, Woodland C, Rieder M,

Canadian Journal of Clinical Pharmacology 2008:

A surveillance method for the early identification

Koren G: Prevention of ifosfamide nephrotoxicity

15: pp e66-e73.

of idiosyncratic adverse drug reactions. Drug Safety 2008: 31: pp 169-180.

by N-acetylcysteine: Clinical pharmacokinetic considerations. Canadian Journal of Clinical Pharmacology 2007: 14: pp 246-250. Chen N, Aleksa K, Woodland C, Rieder M, Koren G:

Dugoua JJ, Seely D, Perri D, Koren G, Mills E: Safety and efficacy of chastetree (vitex agnus-castus)

Feig DS, Briggs GG, Koren G: Oral antidiabetic agents

during pregnancy and lactation. Canadian Journal

in pregnancy and lactation: a paradigm shift? Annals

of Clinical Pharmacology 2008: 15: pp e74-e79.

of Pharmacotherapy 2007: 41: pp 1174-1180.

The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: In vitro studies in renal tubular cells.

Dugoua JJ, Seely D, Perri D, Mills E, Koren G: Safety

Finkelstein Y, Rezvani M, Garcia-Bournissen F,

Translucent Research 2007: 150: pp 51-57.

and efficacy of cranberry (vaccinium macrocarpon)

Nurmohamed L, Koren G: Inactive pharmaceutical

during pregnancy and lactation. Canadian Journal

ingredients: implications for pregnancy. Canadian

De Rosa MF, Ackerley C, Clarke D, Wang B, Ito S,

of Clinical Pharmacology 2008: 15: pp e80-e86.

Journal of Clinical Pharmacology 2007: 14: pp e17-e28.

Lingwood C. Inhibition of multidrug resistance 1 (MDR1) by adamantylGb3, a globotraosylceramide analog.

Einarson A, Koren G: Prescrire des antidépresseurs

Journal of Biology Chemistry 2008: 283: pp 4501-4511.

aux femmes enceintes: que doivent faire les médecins de famille? Canadian Family Physician 2007: 53: pp 1423-1425.

36 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Goh YI, Bollano E, Einarson TR, Koren G: Prenatal

Finkelstein Y, Wahl MS, Bentur Y, Schechter T,

Garcia-Bournissen F, Finkelstein Y, Rezvani M, Koren G:

Garty BZ, Erickson TB, Chodick G, Cahana A,

Exposure to alcohol-containing medications during

multivitamin supplementation and rates of pediatric

Mounstephen WJ, Koren G, Aks SE: Universal versus

pregnancy. Canadian Family Physician 2007: 52:

cancers: a meta-analysis. Clinical Pharmacology

selective iron supplementation for infants and the

pp 1067-1068.

and Therapeutics 2007: 81: pp 685-691.

a comparative study of two populations. Annals of

Garcia-Bournissen F, Rokach B, Karaskov T, Koren G:

Goh YI, Koren G: Folic acid in pregnancy and fetal

Pharmacotherapy 2007: 41: pp 414-419.

Cocaine detection in maternal and neonatal hair:

outcomes. Journal of Obstetrics and Gynaecology

implications to fetal toxicology. Therapeutic Drug

2008: 28: pp 3-13.

risk of unintentional poisoning in young children:

Florescu A, Ferrence R, Einarson TR, Selby P, Kramer M,

Monitoring 2007: 29: pp 71-76. Goldman RD, Ong M, Wolpi J, Doyle J, Parshuram C,

Woodruff S, Grossman L, Rankin A, Jacqz-Aigrain E, Koren G: Reference values for hair cotinine as a

Garcia-Bournissen F, Shrim A, Koren G: Exposure

Koren G: Pharmacological risk factors for

biomarker of active and passive smoking in women

to sibutramine during pregnancy. Canadian Family

amphotericin B nephrotoxicity in children. Journal

of reproductive age, pregnant women, children, and

Physician 2007: 53: pp 229-230.

of Clinical Pharmacology 2007: 47: pp 1049-1054.

Gearing RE, Selkirk EK, Koren G, Leslie M, Motz M,

Goldstein LH, Dolinsky G, Greenberg R, Schaefer C,

Zelazo LB, McNeill T, Lozier FA: Perspectives of

Cohen-Kerem R, Diav-Citrin O, Malm H, Reuvers-

neonates: systematic review and meta-analysis. Therapeutic Drug Monitoring 2007: 29: pp 437-446. Forman R, Gill S, Moretti M, Tulandi T, Koren G,

mothers with substance use problems on father

Lodewijks ME, Rost van Tonningen-van Driel MM,

Casper R: Fetal safety of letrozole and clomiphene

involvement. Canadian Journal of Clinical

Arnon J, Ornoy A, Clementi M, DiGianantonio E, Koren G,

citrate for ovulation induction. Journal of Obstetrics

Pharmacology 2008: 15: pp e99-e107.

Braunstein R, Berkovitch M: Pregnancy outcome of women exposed to azathioprine during pregnancy.

and Gynaecology Canada 2007: 29: pp 668-671. Gedeon C, Anger G, Piquette-Miller M, Koren G:

Birth defects research, Part A. Clinical and Molecular

Garcia-Bournissen F, Asrar F, Verjee Z, Karaskov T,

Breast cancer resistance protein: mediating the

Teratology 2007: 79: pp 696-701.

Koren G: Contamination of hair with 3,4-methylene

trans-placental transfer of glyburide across

dioxymethamphetamine (ecstasy) in two young girls

the human placenta. Placenta 2008: 29: pp 39-43.

from a “meth lab.” Clinical Pediatrics (Philadelphia) 2008: 47: pp 186-188.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 37

Hancock RL, Koren G, Einarson A, Ungar WJ: The

Kirkwood A, Harris C, Timar N, Koren G: Is gentamicin

Koren G, Maltepe C: Preventing recurrence of severe

effectiveness of Teratology Information Services (TIS).

ototoxic to the fetus? Journal of Obstetrics and

morning sickness. Canadian Family Physician 2007:

Reproductive Toxicology 2007: 23: pp 125-132.

Gynaecology Canada 2007: 29: pp 140-145.

52: pp 1545-1546.

Huber AM, Tomlinson GA, Koren G, Feldman BM:

Koren G, Chen N, Aleksa K: Drug-induced

Koren G, Nulman I: Critical appraisal rounds: a new

Amitriptyline to relieve pain in juvenile idiopathic

nephrotoxciity in children: pharmacologically based

training model for clinical pharmacologists. Canadian

arthritis: a pilot study using Bayesian meta-analysis

prevention of long-term impairment. Paediatric

Journal of Clinical Pharmacology 2007: 14: pp e81-85.

of multiple N-of-1 clinical trials. Journal of

Drugs 2007: 9: pp 139-142. Koren G, Pairaideau N: Compliance with prenatal

Rheumatology 2007: 34: pp 1125-1132. Koren G, Kramer M, Mattison D: The Summer

vitamins. Patients with morning sickness sometimes

Humphreys C, Garcia-Bournissen F, Ito S, Koren G:

Institutes in Maternal-Fetal Pharmacology: building

find it difficult. Canadian Family Physician 2007: 52:

Expsoure to attention deficit hyperactivity disorder

critical mass in a neglected area. Journal of Obstetrics

pp 1392-1393.

medications during pregnancy. Canadian Family

and Gynaecology Canada 2007: 29: pp 544-545. Koren G: Changes in drug handling during pregnancy:

Physician 2007: 53: pp 1153-1155. Koren G, MacLeod S, Davis D: Drugs in pregnancy:

what it might mean for your patients. Canadian Family Physician 2007: 52: pp 1214-1215.

Kalra S, Einarson A, Karaskov T, Van Uum S, Koren G:

acknowledging challenges–finding solutions. Canadian

The relationship between stress and hair cortisol in

Journal of Clinical Pharmacology 2007:

healthy pregnant women. Clinical Investigative

14: pp e2-e4.

Koren G: Complementary and alternative medicine for children–time to enter the evidence-based era.

Medicine 2007: 30: pp 103-107.

Canadian Journal of Clinical Pharmacology 2007: 14: p e103. Liu GX, Zhou J, Koren G: Single-channel properties

Dr. Shinya Ito and team

of 1 (K, slow1) and I (K,slow2) in mouse ventricular myocytes. Pflugers Archives 2008: 456(3): pp 541-547.

38 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Kosuge K, Chuang A, Uematsu S, Tan KP, Ko BCB,

O’Brien L, Schachtschneider AM, Koren G, Walker JH,

Sauve B, Koren G, Walsh G, Tokmakejian S,

Ohashi K, Ito S: Discovery of osmo-sensitive

Einarson A: Longitudinal study of depression, anxiety,

Van Uum SH: Measurement of cortisol in human

transcriptional regulation of human cytochrome P450

irritability, and stress in pregnancy following evidence-

hair as a biomarker of systemic exposure. Clinical

3As by the tonicity-responsive enhancer binding

based counseling on the use of antidepressants.

Investigative Medicine 2007: 30: pp 183-191.

protein (nuclear factor of activated T cells 5).

Journal of Psychiatry Practice 2007: 13: pp 33-39. Schechter T, Finkelstein Y, Doyle J, Verjee Z, Moretti M,

Molecular Pharmacology 2007: 72: pp 826-837. Parshuram CS, To T, Seto W, Trope A, Koren G,

Koren G, Dupuis LL: Pharmacokinetic disposition and

Lau AC, Duong TT, Ito S, Yeung RSM: Matrix

Laupacis A: Systematic evaluation of errors occurring

clinical outcomes in infants and children receiving

metalloproteinase-9 activity leads to coronary

during the preparation of intravenous medication.

intravenous busulfan for allogeneic hematopoietic

aneurysms in an animal model of Kawasaki disease.

Canadian Medical Association Journal 2008: 178: pp 42-48.

stem cell transplantation. Biology Blood Marrow Transplant 2007: 13: pp 307-314.

Arthritis and Rheumatism 2008: 58: pp 854-863. Pereg D, Koren G, Lishner M: The treatment of Madadi P, Koren G, Cairns J, Chitayat D, Gaedigk A,

Hodgkin’s and non-Hodgkin’s lymphoma in pregnancy.

Seely D, Dugoua JJ, Perri D, Mills E, Koren G: Safety

Leeder JS, Teitelbaum R, Karaskov T, Aleksa K: Safety

Haematologica 2007: 92: pp 1230-1237.

and efficacy of panax ginseng during pregnancy and lactation. Canadian Journal of Clinical Pharmacology

of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother

Piwko C, Ungar WJ, Einarson TR, Wolpin J, Koren G:

prescribed codeine. Canadian Family Physician 2007:

The weekly cost of nausea and vomiting of pregnancy

53: pp 33-35.

for women calling the Toronto Motherisk Program.

2008: 15: pp e87-e94. Shor S, Koren G, Nulman I: Teratogenicity of

Current Medical Research Opinion 2007: 23: pp 833-840.

lamotrigine. Canadian Family Physician 2007: 53: pp 1007-1009.

Moretti ME, Verjee Z, Ito S, Koren G: Breastfeeding during maternal use of azathioprine. Annals of

Ray JG, Vermeulen MJ, Koren G: Taking ACE inhibitors

Pharmacotherapy 2007: 40: pp 2269-2272.

during early pregnancy: is it safe? Canadian Family

Shrim A, Garcia-Bournissen F, Koren G: Pharmaceutical agents and pregnancy in urology

Physician 2007: 53: pp 1439-1440.

practice. Urology Clinical North America 2007:

Nava-Ocampo AA, Koren G: Human teratogens and evidence-based teratogen risk counseling:

Rezvani M, Finkelstein Y, Verjee Z, Railton C, Koren G:

the Motherisk approach. Clinical Obstetrics and

Generalized seizures following topical lidocaine

Gynaecology 2007: 50: pp 123-131.

administration during circumcision: establishing

34: pp 27-33.

causation. Paediatric Drugs 2007: 9: pp 125-127.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 39

Shrim A, Garcia-Bournissen F, Maxwell C, Farine D,

Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,

Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang J, Mao L,

Koren G: Favorable pregnancy outcome following

Ota S, Feldman BM: Serial controlled N-of-1 trials of

Chuprun JK, Koch WJ, Liao R, Koren G, Blaxall BC,

Trastuzumab (Herceptin) use during pregnancy–case

topical vitamin E as prophylaxis for chemotherapy-

Mende U: Enhanced calcium cycling and contractile

report and updated literature review. Reproductive

induced oral mucositis in paediatric patients.

function in transgenic hearts expressing constitutively

Toxicology 2007: 23: pp 611-613.

European Journal of Cancer 2007: 43: pp 1269-1275.

active G (alpha) protein. American Journal of Physiology–Heart and Circulatory Physiology 2008:

Shrim A, Garcia-Bournissen F, Maxwell C, Farine D,

Sutander M, Garcia-Bournissen F, Koren G:

Koren G: Trastuzumab treatment for breast cancer

Hypothyroidism in pregnancy. Journal of Obstetrics

during pregnancy. Canadian Family Physician 2008:

and Gynaecology Canada 2007: 29: pp 354-356.

54: pp 31-32.

294(3): pp H1335-H1347.

BOOKS AND BOOK CHAPTERS Addis A, Koren G: Safety of fluoxetine during the first

Taguchi N, Mian M, Shouldice M, Karaskov T, Gareri J,

trimester of pregnancy: a meta-analytical review of

Sivojelezova A, Koren G, Einarson A: Glucosamine use

Nulman I, Verjee ZH, Koren G: Chronic cocaine

epidemiological studies. In: The Evidence-Based A-to-Z

in pregnancy: an evaluation of pregnancy outcome.

exposure in a toddler revealed by hair test. Clinical

Clinician’s Pocket Guide, Part II, Section 4. McGraw

Journal of Women’s Health 2007: 16: pp 345-348.

Pediatrics 2007: 46: pp 272-275.

Hill, New York, 2007.

Stade B, Ungar WJ, Stevens B, Beyen J, Koren G:

Tan KP, Yang M, Ito S: Activation of Nrf2 by toxic

Addis A, Moretti EM, Syed AF, Einarson RT, Koren G:

Cost of fetal alcohol syndrome disorder in Canada.

bile acids provokes adaptive defense responses to

Fetal effects of cocaine: an updated meta-analysis.

Canadian Family Physician 2007: 53: pp 1303-1304.

enhance cell survival at the emergence of oxidative

In: The Evidence-Based, A-to-Z Clinician’s Pocket

stress. Molecular Pharmacology 2007: 72: pp 1380-1390.

Guide, Part II, Section 3. McGraw Hill, New York, 2007.

American Gastroenterological Association Institute

Yamada J, Stevens B, de Silva N, Gibbins S, Beyene J,

Bar-Oz B, Hackman R, Einarson RT, Koren G:

Staroselsky A, Garcia-Bournissen F, Koren G: medical position statement on the use of

Taddio A, Newman C, Koren G: Hair cortisol as a

Pregnancy outcome after cyclosporine therapy during

gastrointestinal medication in pregnancy.

potential biologic marker of chronic stress in hospitalized

pregnancy: a meta-analysis. In: The Evidence-Based,

Gastroenterology 2007: 132: pp 824-825.

neonates. Neonatology 2007: 92: pp 42-49.

A-to-Z Clinician’s Pocket Guide, Part II, Section 4. McGraw Hill, New York, 2007.

Staroselsky A, Nava-Ocampo AA, Vohra S, Koren G: Hemorrhoids in pregnancy. Canadian Family Physician 2008: 54: pp 189-190.

40 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Bar-Oz B, Moretti EM, Mareels G, Van Tittelboom T,

Bentur Y, Koren G: The common occupational

Dolovich RL, Addis A, Vaillancourt JMR, Power JDB,

Koren G: Reporting bias in retrospective

exposures encountered by pregnant women. In:

Koren G, Einarson RT: Benzodiazepine use in

ascertainment of drug-induced embryopathy. In: The

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

pregnancy and major malformations or oral cleft:

Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part

Part I. McGraw Hill, New York, 2007.

meta-analysis of cohort and case-control studies. In: The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

II, Section 1. McGraw Hill, New York, 2007. Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G:

Part II, Section 4. McGraw Hill, New York, 2007.

Ben David S, Einarson RT, Ben David Y, Nulman I,

Perinatal risks of untreated depression during

Pastuszak A, Koren G: The safety of nitrofurantoin

pregnancy. In: The Evidence-Based, A-to-Z Clinician’s

Einarson RT, Koren G, Mattice D, Schechter-Tsafriri C:

during the first trimester of pregnancy: a meta-

Pocket Guide, Part I. McGraw Hill, New York, 2007.

Maternal spermicide use and adverse reproductive

Pocket Guide, Part II, Section 4. McGraw Hill, New

Burtin P, Taddio A, Ariburnu O, Einarson RT, Koren G:

A-to-Z Clinician’s Pocket Guide, Part II, Section 4.

York, 2007.

Safety of metronidazole in pregnancy: a meta-analysis.

McGraw Hill, New York, 2007.

Bennett AH, Einarson A, Taddio A, Koren G, Einarson

Guide, Part II, Section 4. McGraw Hill, New York, 2007.

outcome: A meta-analysis. In: The Evidence-Based,

analysis. In: The Evidence-Based, A-to-Z Clinician’s

In: The Evidence-Based, A-to-Z Clinician’s Pocket Einarson RT, Leeder JS, Koren G: A method for meta-analysis of epidemiological studies. In: The

RT: Prevalence of depression during pregnancy: systematic review. In: The Evidence-Based, A-to-Z

Cohen-Kerem R, Railton C, Oren D, Lishner M,

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Clinician’s Pocket Guide, Part II, Section 2. McGraw

Koren G: Pregnancy outcome following non-obstetric

Part II, Section 1. McGraw Hill, New York, 2007.

Hill, New York, 2007.

surgical intervention. In: The Evidence-Based,

Bentur Y, Koren G: Occupational exposures known

A-to-Z Clinician’s Pocket Guide, Part II, Section 2.

Fernandes O, Sabharwal M, Smiley T, Pastuszak A,

McGraw Hill, New York, 2007.

Koren G, Einarson T: Moderate to heavy caffeine consumption during pregnancy and relationship to

to be human reproductive poisons. In: The EvidenceBased, A-to-Z Clinician’s Pocket Guide, Part I.

Diav-Citrin O, Koren G: Direct drug toxicity to the fetus.

spontaneous abortion and abnormal fetal growth:

McGraw Hill, New York, 2007.

In: The Evidence-Based, A-to-Z Clinician’s Pocket

a meta-analysis. In: The Evidence-Based, A-to-Z

Guide, Part I. McGraw Hill, New York, 2007.

Clinician’s Pocket Guide, Part II, Section 3. McGraw Hill, New York, 2007.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 41

Fried S, Kozer E, Nulman I, Einarson RT, Koren G:

Gilbert C, Valois M, Koren G: Pregnancy outcome after

Hard LM, Einarson RT, Koren G: The role of

Malformation rates in children of women with

first-trimester exposure to metformin: a meta-analysis.

acetaldehyde in pregnancy outcome after prenatal

untreated epilepsy: a meta-analysis. In: The

In: The Evidence-Based, A-to-Z Clinician’s Pocket

alcohol exposure. In: The Evidence-Based, A-to-Z

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Guide, Part II, Section 4. McGraw Hill, New York, 2007.

Clinician’s Pocket Guide, Part II, Section 3. McGraw Hill, New York, 2007.

Part II, Section 2. McGraw Hill, New York, 2007. Goh YI, Bollano E, Einarson RT, Koren G: Prenatal Gareri NJ, Klein J, Koren G: Determination of prenatal

multivitamin supplementation and rates of congenital

Hemels EHM, Einarson A, Koren G, Lanctot LK,

exposures: In: The Evidence-Based, A-to-Z Clinician’s

anomalies: a meta-analysis. In: The Evidence-Based,

Einarson RT: Antidepressant use during pregnancy

Pocket Guide, Part I. McGraw Hill, New York, 2007.

A-to-Z Clinician’s Pocket Guide, Part II, Section 4.

and the rates of spontaneous abortions: a meta-

McGraw Hill, New York, 2007.

analysis. In: The Evidence-Based, A-to-Z Clinician’s

disposition in the maternal-fetal unit. In: The Evidence-

Goh YI, Koren G: Folic acid and congenital birth defects:

York, 2007.

Based, A-to-Z Clinician’s Pocket Guide, Part II. McGraw

a review. In: The Evidence-Based, A-to-Z Clinician’s

Hill, New York, 2007.

Pocket Guide, Part I. McGraw Hill, New York, 2007.

Pocket Guide, Part II, Section 4. McGraw Hill, New

Gedeon C, Koren G: Gestational changes in drug

Koren G, Nava-Ocampo AA, Moretti EM, Sussman R, Nulman I: Major malformations with valproic acid. In:

Gilbert C, Mazzotta P, Loebstein R, Koren G: Fetal

Gutzin J, Kozer E, Magee AL, Feig SD, Koren G:

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

safety of drugs used in the treatment of allergic

The safety of oral hypoglycemic agents in the first

Part II, Section 4. McGraw Hill, New York, 2007.

rhinitis: a critical review. In: The Evidence-Based,

trimester of pregnancy: a meta-analysis. In: The

A-to-Z Clinician’s Pocket Guide, Part II, Section 4.

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Koren G: Bias against the null hypothesis in

McGraw Hill, New York, 2007.

Part II, Section 4. McGraw Hill, New York, 2007.

maternal-fetal pharmacology and toxicology. In: The Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part II, Section 1. McGraw Hill, New York, 2007.

42 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

McMartin IK, Chu M, Kopecky E, Einarson RT, Koren G:

Koren G: Drugs in pregnancy: acknowledging

Magee AL, Elran E, Bull BS, Logan A, Koren G: Risks

challenges–finding solutions. In: The Evidence-Based,

and benefits of β-receptor blockers for pregnancy

Pregnancy outcome following maternal organic solvent

A-to-Z Clinician’s Pocket Guide, Part I. McGraw Hill,

hypertension: overview of the randomized trials. In:

exposure: a meta-analysis of epidemiologic studies.

New York, 2007.

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

In: The Evidence-Based, A-to-Z Clinician’s Pocket

Part II, Section 4. McGraw Hill, New York, 2007.

Guide, Part II, Section 3. McGraw Hill, New York, 2007.

In: The Evidence-Based, A-to-Z Clinician’s Pocket

Magee AL, Mazzotta P, Koren G: Evidence-based view

Moretti EM, Bar-Oz B, Fried S, Koren G: Maternal

Guide, Part I. McGraw Hill, New York, 2007.

of safety and effectiveness of pharmacologic therapy

hyperthermia and the risk for neural tube defects in

for nausea and vomiting during pregnancy (NVP). In:

offspring: systematic review and meta-analysis. In:

Koren G: Risk of varicella infection during late pregnancy.

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

In: The Evidence-Based, A-to-Z Clinician’s Pocket

Part II, Section 4. McGraw Hill, New York, 2007.

Part II, Section 2. McGraw Hill, New York, 2007.

Koren G: Medication in pregnancy and breastfeeding.

Guide, Part II, Section 2. McGraw Hill, New York, 2007. Makarechian N, Agro K, Devline J, Trepanier E,

Nava-Ocampo AA, Talaie H, Koren G: Systematic

Kozer E, Nikfar S, Costei A, Boskovic R, Nulman I,

Koren G, Einarson RT: Association between

review of randomized controlled trials and cohort

Koren G: Aspirin consumption during the first

moderate alcohol consumption during pregnancy and

studies on pregnancy outcome following antiretroviral

trimester of pregnancy and congenital anomalies:

spontaneous abortion, stillbirth and premature birth:

treatment in pregnancy. In: The Evidence-Based,

a meta-analysis. In: The Evidence-Based, A-to-Z

A meta-analysis. In: The Evidence-Based, A-to-Z

A-to-Z Clinician’s Pocket Guide, Part II, Section 4.

Clinician’s Pocket Guide, Part II, Section 4.

Clinician’s Pocket Guide, Part II, Section 3. McGraw

McGraw Hill, New York, 2007.

McGraw Hill, New York, 2007.

Hill, New York, 2007.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 43

Nikfar S, Abdollahi M, Moretti EM, Magee AL, Koren G:

Nulman I, Sussman R, Farber N, Chitayat D, Koren G:

Raman-Wilms L, Tseng Lin-in A, Wighardt S, Einarson RT,

Use of proton pump inhibitors during pregnancy and

Fetal malformations associated with drugs and

Koren G: Fetal genital effects of first-trimester sex

rates of major malformations: a meta-analysis. In: The

chemicals: visualization by sonography/fetal MRI. In:

hormone exposure: a meta-analysis. In: The

Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part

The Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

II, Section 4. McGraw Hill, New York, 2007.

Part I. McGraw Hill, New York, 2007.

Part II, Section 4. McGraw Hill, New York, 2007. Seto A, Einarson RT, Koren G: Evaluation of

Nulman I, Izmaylov Y, Staroselsky A, Koren G:

Park-Wyllie L, Mazotta P, Pastuszak A, Moretti EM,

Teratogenic drugs and chemicals in humans. In: The

Beique L, Hunnisett A, Friesen HM, Jacobson S,

brompheniramine safety in pregnancy. In: The

Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part I.

Kasapinovic S, Chang D, Diav-Citrin O, Chitayat D,

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Nulman I, Einarson RT, Koren G: Birth defects after

Part II, Section 4. McGraw Hill, New York, 2007.

McGraw Hill, New York, 2007.

maternal exposure to corticosteroids: prospective Seto A, Einarson RT, Koren G: Pregnancy outcome

Nulman I, Knittel-Kerem D, Koren G: Fetal Alcohol

cohort study and meta-analysis of epidemiological

Spectrum Disorder: the central nervous system

studies. In: The Evidence-Based, A-to-Z Clinician’s

following first trimester exposure to antihistamines:

tragedy. In: The Evidence-Based, A-to-Z Clinician’s

Pocket Guide, Part II, Section 4. McGraw Hill, New

a meta-analysis. In: The Evidence-Based, A-to-Z

Pocket Guide, Part I. McGraw Hill, New York, 2007.

York, 2007.

Clinician’s Pocket Guide, Part II, Section 4. McGraw

Nulman I, Koren G: Epilepsy and pregnancy.

Polygenis D, Wharton S, Malmberg C, Sherman N,

In: The Evidence-Based, A-to-Z Clinician’s Pocket

Kennedy D, Koren G, Einarson RT: Moderate alcohol

Sivojelezova A, Gallo M, Bollano E, Boom H, Koren G:

Hill, New York, 2007.

consumption during pregnancy and the incidence

The use of natural health products in pregnancy and

of fetal malformations: a meta-analysis. In: The

lactation. In: The Evidence-Based, A-to-Z Clinician’s

Nulman I, Laslo D, Fried S, Uleryk E, Lishner M,

Evidence-Based, A-to-Z Clinician’s Pocket Guide,

Pocket Guide, Part I. McGraw Hill, New York, 2007.

Koren G: Neurodevelopment of children exposed

Part II, Section 3. McGraw Hill, New York, 2007.

Guide, Part I. McGraw Hill, New York, 2007.

in utero to treatment of maternal malignancy. In: The Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part II, Section 4. McGraw Hill, New York, 2007.

44 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

von Dadelszen P, Ornstein MP, Bull SB, Logan AG,

Genotype-specific approaches in therapeutics in

Novel transcriptional control of human CYP3A.

Koren G, Magee AL: Fall in mean arterial pressure

children. Carlton B, Hayden M, Ito S. University of

Ito S. Canadian Institute of Health Research

and fetal growth restriction in pregnancy hypertension:

British Columbia ($105,000 2005-2007)

($340,540 2007-2010)

a meta-analysis. In: The Evidence-Based, A-to-Z Clinician’s Pocket Guide, Part II, Section 2. McGraw

Hair analysis for cortisol and testosterone. Van Um S,

Pharmacogenetics of adverse drug reactions in

Hill, New York, 2007.

Koren G. The Physicians Services Incorporated

children. Carlton B, Hayden M, Ito S, Koren G.

Foundation ($130,000 2006-2008)

Genome Canada ($350,000 2005-08)

Determinants of renal handling of drugs during

Improving prenatal vitamins to women. Koren G.

The role of placenta in fetal toxicology. Koren G.

development. Koren G. Canadian Institutes of Health

Duchesnay Incorporated ($400,000 2004-2007)

FUNDING Canadian Institutes of Health Research ($584,309 2007-2011)

Research ($583,800 2003-2008) Neurodevelopment after fetal exposure to supradose Drugs and human milk. Ito S. Canadian Institutes of

diclectin. Koren G, Nulman I. Duchesnay Incorporated

Health Research ($376,323 2007-2010)

($480,000 2005-2008)

Drugs and human milk. Ito S. Canadian Institutes of

New Emerging Team (NET) grant. Koren G, Brien J.

Health Research ($645,998 2002-2007)

Canadian Institutes for Health Research ($1,250,000 2002-2007)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 45

Dr. Darcy Fehlings

DIVISION HEAD Dr. Darcy Fehlings FULL-TIME Dr. Douglas Biggar Dr. Elizabeth Jimenez

Dr. Dr. Dr. Dr. Dr. Dr.

Tamarah Kagan-Kushnir Alvin Loh Laura McAdam Anne Kawamura Golda Milo-Manson Angela Orsino

Dr. Wendy Roberts Dr. Jay Rosenfield Dr. Peter Rumney

PART-TIME AND/OR COMMUNITY PHYSICIANS Dr. Janine Flanagan Dr. Cynthia Goldfarb Dr. Mark Handley-Derry

Dr. Nicola Jones-Stokreef Dr. Peggy Kirkpatrick Dr. Donal O’Leary Dr. Anne Richards Dr. Clive Schwartz Dr. David Shawn Dr. Diann Superina

CROSS-APPOINTEES/ SCIENTIFIC STAFF Dr. Colin Macarthur Dr. Patricia McKeever

Division of Developmental Paediatrics OVERVIEW

The division members actively lead and participate in

PUBLICATIONS

The Division of Developmental Paediatrics is situated

applied clinical research in child development and

Angus J, Paszat LF, McKeever P, Trebilcock A, Shivji F,

at Bloorview Kids Rehab. The division consists of

rehabilitation, in association with the Bloorview

Edwards B: Pathways to breast cancer diagnosis

11 full-time physicians as well as a strong community

Research Institute led by Dr. Colin MacArthur. Two

and treatment: exploring the social relations of

section of developmental paediatricians. The main

exciting projects initiated this year are the CIHR-funded

diagnostic delay. Texto and Contexto Enfermagem

clinical focus of the division is on childhood

research evaluating the long-term effectiveness of

2007: 16(4): pp 591-598.

developmental disorders such as cerebral palsy,

botulinum toxin injections in children with cerebral

and autism spectrum disorders. In addition, there

palsy, and the identification of Toronto as a research

Au H, Harrison M, Ahmet A, Orsino A, Beck C, Tallett S,

is a strong rehabilitation component with the acquired

site in the North American Autism Treatment Network.

Gans M, Birken C: Residents as health advocates:

year, the division welcomed Dr. Angela Orsino, a

HONOURS AND AWARDS

a child advocacy initiative at the University of Toronto.

developmental paediatrician whose clinical expertise

Fehlings D: Inaugural Holder, Bloorview Children’s

Paediatrics and Child Health 2007: 12(7): pp 567-571.

brain injury and neuromuscular programs. This

focusses on children with autism spectrum disorders.

the development, implementation and evaluation of

Hospital Foundation/University of Toronto Chair in Developmental Paediatrics, 2007.

Within the division, there is a strong commitment

Bonati MT, Russo S, Finelli P, Valsecchi MR, Cogliati F, Cavalleri F, Roberts W, Elia M, Larizza L: Evaluation of

to education. Under the leadership of Dr. Golda

Macarthur C: Inaugural Holder, Bloorview Children’s

Milo-Manson as program director, the fully accredited

Hospital Foundation/University of Toronto Chair in

autism traits in Angelmans syndrome: a resource to unfold autism genes. Neurogenetics 2007: 8(3):

subspecialty residency program in Developmental

Paediatric Rehabilitation, 2007.

pp 169-178.

also a strong commitment to training paediatric

McKeever P: Inaugural Holder, Bloorview Kids

Carnevale FA, Macdonald ME, Bluebond-Langner M,

and psychiatry residents and medical students

Foundation/University of Toronto Childhood

McKeever P: Using participant observation in pediatric

in applied child development.

Chair in Disability Studies, 2007.

Paediatrics is the largest in Canada. There is

health care settings: ethical challenges and solutions. Journal of Child Health Care 2008: 12(1): pp 18-32.

An exciting event for the division was the creation in

Roberts W: Division of Developmental

2007 of the Bloorview Children’s Hospital Foundation/

Paediatrics Faculty Teaching Award, 2008.

University of Toronto Endowed Chair in Developmental Paediatrics. Dr. Darcy Fehlings, Division Head, is the

Schwartz C: Dr. R H A Haslam Pre-Clerkship Teaching

inaugural holder of this leadership chair.

Award for Excellence in Pre-Clerkship Teaching, 2008.

FELLOWS Dr. Ghassan Abu Kuwaik Dr. Kassia Johnson Dr. Sharon Smile Dr. Lyn Sonnenberg

ADMINISTRATIVE STAFF AT BLOORVIEW KIDS REHAB Merlene Chin Deborah Horner Joanne Jenah Romana Karnetova

ADMINISTRATIVE STAFF Maureen Hodge Barbara Zimnowodzki

Epstein I, Stevens S, McKeever P, Baruchel S: Using a puppet to elicit talk with children. Nursing Inquiry 2008: 15(1): pp 49-56.

Huertas-Ceballos, Logan S, Bennett C, Macarthur C:

Gibbins S, Stevens S, McGrath P, Yamada J, Beyene J,

Harrop A, Brant R, Ghali W, Macarthur C: Injury

Breau L, Camfield C, Finley A, Franck L, Johnston C,

mortality rates in native and non-native children:

Psychosocial interventions for recurrent abdominal

Howlett A, McKeever P, O’Brien K, Ohlsson A:

a population-based study. Public Health Reports

pain (RAP) and irritable bowel syndrome (IBS) in

Comparison of pain responses in infants of different

2007: 122: pp 339-346.

childhood. Cochrane Database Systems Review 2008: 1: CD003014.

gestational ages. Neonatology 2008: 93: pp 10-18. Hewitt A, Macarthur C, Raina P: The role of evidence Gibson B, McKeever P: Men on the margin:

in public health policy: an example of linkage and

Kingsnorth S, Healy H, Macarthur C: Preparing for

a Bourdieusian examination of living into adulthood

exchange in the prevention of scald burns. Health

adulthood: a systematic review of life skill programs

with muscular dystrophy. Social Science and

Care Policy 2007: 3: pp 59-66.

for youth with physical disabilities. Journal of Adolescent Health 2007: 41: pp 323-332.

Medicine 2007: 65(3): pp 505-517. Hudak P, McKeever P, Wright JG: Unstable embodiments: a phenomenological interpretation of

Kolski HK, Hawkins C, Zatz M, de Flavia P, Biggar WD,

technology, and place: social and ethical implications

patient satisfaction with treatment outcome. Journal

Alman B, Vajsar J: Diagnosis of limb-girdle muscular

of long-term dependency on medical devices. Ethics,

of Medical Humanities 2007: 28(1): pp: 1041-3545.

dystrophy 2A by immunohistochemical techniques.

Gibson B, Upshur R, Young N, McKeever P: Disability,

Neuropathology 2008: 28(3): pp 264-268.

Place and Environment 2007: 10(1): pp 7-28. Huertas-Ceballos, Logan S, Bennett C, Macarthur C: Guerriere D, Wong A, Croxford R, Leong V, McKeever P,

Dietary interventions for recurrent abdominal pain

Moessner R, Marshall CR, Sutcliffe JS, Skaug J,

Coyte P: Costs and determinants of privately-financed

(RAP) and irritable bowel syndrome (IBS) in childhood.

Pinto D, Vincent J, Zwaigenbaum L, Fernandez B,

home-based health care in Ontario, Canada. Health

Cochrane Database Systems Review 2008: 1:

Roberts W, Szatmari P, Scherer SW: SHANK3

and Social Care in the Community 2008: 16(2):

CD003019.

mutations to autism spectrum disorder. American Journal of Human Genetics 2007: 81(6): pp 1289-1297.

pp 126-136. Huertas-Ceballos, Logan S, Bennett C, Macarthur C: Han R, Ungar W, Macarthur C: Cost effectiveness

Pharmacological interventions for recurrent abdominal

Narayanan U, Knights S, Weir S, Livingston M,

analysis of a proposed public health legislative/

pain (RAP) and irritable bowel syndrome (IBS) in

Fehlings D: Does the health status of caregivers

educational strategy to reduce tap water scald injuries

childhood. Cochrane Database Systems Review 2008:

influence their perception of the health-related quality

in children. Injury Prevention 2007: 13: pp 248-253.

1: CD003017.

of life of children with severe non-ambulatory cerebral palsy? Developmental Medicine and Child Neurology 2007: 49(111): pp 31-21.

48 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Narayanan U, Weir S, Smith J, Fehlings D: Impact of

Stevens B, McGrath P, Gibbins S, Beyene J, Breau L,

Yantzi NM, Rosenberg MW, McKeever P: Getting out of

comorbidities on the health-related quality of life of

Camfield C, Finley A, Franck L, Howlett A, Johnston C,

the house: the challenges mothers face when children

children with severe non-ambulatory cerebral palsy.

McKeever P, O’Brien K, Ohlsson A, Yamada J:

have long-term care needs. Health and Social Care in

Developmental Medicine and Child Neurology 2007:

Determining behavioural and physiological responses

the Community 2007: 15(1): pp 45-55.

49(111): p 68.

to pain in infants at risk for neurological impairment.

BOOKS AND BOOK CHAPTERS

Pain 2007: 127: pp 94-102. Peter E, Spalding K, Kenny N, Conrad P, McKeever P,

England K, Eakin J, Gastaldo D, McKeever P:

Macfarlane A: Neither seen nor heard: children and

Sutcliffe TL, Gaetz WC, Logan WJ, Cheyne DO,

Neoliberalizing home care: managed competition and

home care policy in Canada. Social Science and

Fehlings DL: Cortical reorganization after modified

restructuring home care in Ontario. In Neo-liberalization:

Medicine 2007: 64(8): pp 1624-1635.

constraint-induced movement therapy in pediatric

States, Networks, Peoples (England K, Ward K, eds.).

hemiplegic cerebral palsy. Journal of Child Neurology

Blackwell Publishing Ltd., London, UK, 2007.

Pope E, Krafchik B, Macarthur C, Stempak D,

2007: 22(11): pp 1281-1287.

FUNDING

Stephens D, Weinstein M, Ho N, Baruchel S: Oral versus high-dose pulse corticosteroids for problematic

Tallett S, Lingard L, Leslie K, Pirie J, Jeffries A,

A molecular genetic study of autism and related

infantile hemangiomas: a randomized, controlled trial.

Spero L, Schneider R, Hilliard R, Rosenfield J,

phenotypes in extended pedigrees. Szatmari P,

Hellman J, Mian M, Hurley J: Measuring educational

Zwaigenbaum L, Scherer S, Vincent J, Roberts SW,

workload: a pilot study of paper-based and PDA tools.

Goldberg J, Mahoney W, Fernandez B. Canadian

Medical Teacher 2008: 30(3): pp 296-301.

Institutes of Health Research ($550,000 2006-2011)

chronic abdominal pain: role of selected laboratory

Wright V, Rosenbaum P, Goldsmith C, Law M, Fehlings

An evaluation of the long-term effectiveness of

investigations (stool ova and parasites, complete

D: How do changes in body functions/structures,

botulinum toxin in children with spastic cerebral palsy. Fehlings D, Goldsmith C, Narayanan U, Rosenbaum P,

Pediatrics 2007: 119: pp 1239-1247. Soon G, Saunders N, Ipp M, Sherman PM, Macarthur C: Community-based case-control study of childhood

blood count, and erythrocyte sedimentation rate).

activity, and participation relate? A study of children

Journal of Pediatric Gastroenterology and Nutrition

with cerebral palsy (CP). Developmental Medicine and

Wright W. Canadian Institutes of Health Research

2007: 44: pp 524-526.

Child Neurology 2008: 50: pp 283-289.

($425,956 2008-2012)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 49

A qualitative observational study of resident oral

Books for siblings of children with autism. Johnson K,

Critical reflections on ambulatory training for children

paediatric developmental case presentations.

McKeever P, Kawamura A. Bloorview Research

with cerebral palsy. Gibson B, Wright V, Yong NL,

Orsino A, Kawamura A, Lingard L, Fehlings D.

Institute Seed Grant ($5,500 2007-2008)

McKeever P, McLaren C, Fehlings D. Health Care, Technology and Place: Interdisciplinary Capacity

Bloorview Research Institute ($10,553 2008-2009) Canadian Injury Indicators Development, Phase II.

Enhancement Team Grant ($8,000 2007-2008)

Autism genome project. Scherer SW, Szatmari P,

Pike I, Macpherson A, Macarthur C, Warda L, Babul S,

Paterson AD, Vincent JB, Zwaigenbaum L, Roberts W,

Goodman D, Raina P. Canadian Institutes of Health

Development of an indicator of the impact of assistive

Wellington SR, Fernandez BA, Miller FA, Hallmayer JF.

Research ($225,000 2008-2011)

devices on children with disabilities and their families. Ryan S, Campbell K, McKeever P, Montpetit K,

Genome Canada ($15,611,534 2005-2009) Cerebral Palsy Outcomes Project (CPOP). Fehlings D,

Perkin S, Rigby P, Roxborough L, Stevens J. Canadian

Autism spectrum disorders: pathways to better

Kolaski K, Gaebler-Spira D, Kuroda M, Msall M,

Institutes of Health Research ($225,000 2008-2011)

outcomes. Szatmari P, Bryson SE, Fombonne E,

Thornton L, Moberg-Wolff E, Krach L, Hurvitz E.

and Research Institute ($100,000 2008-2011)

Zwaigenbaum L, Smith I, Waddell C, Vaillancourt T,

American Academy for Cerebral Palsy and

Mirenda P, Roberts W, Volden J. Canadian Institutes

Developmental Medicine ($25,000 2007-2008)

Discriminating autism from other atypical patterns of development in a community sample. Roncadin C,

of Health Research ($2,125,000 2004-2009) Clowning around: the effects of therapeutic clowning

Roberts W, Niccols A, Brian J, Bryson S, Smith I,

Autism Treatment Network: Co-operative multicentre

on patients and nurses in a paediatric rehabilitation

Zwaigenbaum L. The Ontario Mental Health

program for research and treatment of autism.

facility. Kingsnorth S, McKeever P, Blaine S. Bloorview

Foundation (Type A Grant) ($142,005 2008-2010)

Roberts W, Loh A, Kawamura A, Feigenbaum A,

Children’s Hospital Foundation ($24,985 2008-2009) Early developmental trajectories in autism.

Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J,

Costs incurred by families of children newly diagnosed

Zwaigenbaum L, Bryson SE, Roberts S, Smith I,

Mitchell S, Kawamura A, Green P. Autism Speaks

with cancer. Stevens B, Tsimicalis A, Greenberg M,

Szatmari P, Vaillancourt T. Canadian Institutes of

($450,000 2008-2010)

McKeever P, Ungar W, Guerriere D, Agha M. National

Health Research ($932,585 2006-2011)

Cancer Institute of Canada ($330,712 2006-2008)

50 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Enhancing inter-subjectivity in infants at high risk for

From knowledge generation to knowledge translation:

Genome wide DNA methylation profiling in autism.

autism. Bryson S, Brian J, Smith I, Zwaigenbaum L,

a systems approach to reducing the burden of injury in

Weksberg R, Roberts SW, Scherer S. Canadian

Roberts SW. Autism Speaks ($638,006 2007-2010)

Canada. Macarthur C, Raina P. Canadian Institutes of

Institutes of Health Research ($649,518 2008-2011)

Health Research ($942,361 2003-2008) HCTP & The Change Foundation Strategic Alliance.

Evaluating outcomes associated with multidisciplinary care for children with cerebral palsy using clinical

Functional status outcome indicators for young

McKeever P, Coyte PC. The Change Foundation

practice improvement (CPI) methodology. Damiano D,

children with cerebral palsy: evaluation of the

(2003-2008 $200,000)

Chambers H, Revivo G, Brunstrom J, Horn S,

comparative abilities of two internationally-recognized

Gassaway J, Krach L, Gormley M, Novacheck T,

measures to detect change, and determination of

Identity, embodiment and heart transplantation:

Matthews D, Chang F, Stevenson R, Abel M,

benchmarks for clinically important change. Wright V,

a phenomenologically-informed exploration. Ross H,

McLaughlin J, Bjornson K, Rathjen K, Delgado M,

Stratford P, Goldsmith C, Rigby P, Fehlings D,

McKeever P, Shildrick M, Poole J. Advanced Heart

Dabrowski E, Gaebler-Spira D, Dias L, Narayanan U,

Rosenbaum P. Canadian Institutes of Health

Failure Fund (2008-2009 $75,000)

Fehlings D, Graham K, Koman A. American Academy

Research ($174,565 2008-2010) Inappropriate living environments for children

for Cerebral Palsy and Developmental Medicine Clinical Research Planning Grant ($29,000 2006-2007)

Functional outcomes following orthopaedic surgery

with acquired brain injury. Law M, Colantonio A,

based on gait laboratory versus observational gait

DeMatteo C, Macarthur C. Ontario Neurotrauma

Evaluation of the reliability, validity and

analysis in ambulatory children with cerebral palsy:

Foundation ($150,000 2005-2007)

responsiveness of the Kinematic Dystonia measure in

a randomized controlled trial. Narayanan U, Willan A,

children with upper extremity dystonia. Kawamura A,

Wedge J, Fehlings D. Pediatric Orthopaedic Society

Fehlings D, Morris A, Campbell K. Bloorview Research

of North America (POSNA) ($31,000 2006-2008)

Interdisciplinary capacity enhancement grant for “Health Care, Technology and Place”: a CIHR Centre for Research Development. Coyte PC, McKeever P.

Institute Seed Grant ($16,652 2007-2008) Functional outcomes following orthopaedic surgery

Canadian Institutes of Health Research

Evaluation of quality of movement in ambulatory

based on gait laboratory versus observational gait

($1,000,000 2003-2008)

children with cerebral palsy: validity and sensitivity

analysis in ambulatory children with cerebral palsy:

to change of the quality FM. Rosenbaum P,

a pilot randomized controlled trial. Narayanan U,

Wright V, Mesterman R, Fehlings D, Kim M.

Fehlings D, Willan A, Wedge J, Redekop S.

McKeever P, Hodnett E, Carter M, Vanderby S,

Physicians’ Services Incorporated Foundation

Bloorview Research Institute Seed Grant

Adams A, Theodore D, Jewell S, Koziel N.

($125,000 2007-2009)

Competition ($25,015 2006-2007)

Philips Electronics ($134,578 2006-2008)

Kids’ ambient MRI suite conversion study. Babyn P,

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 51

Medical Technologies Research and Commercialization

Role of telecommunication in augmentative

The efficacy of an intelligent prompting system to

Collaborative. Phipps D, Macarthur C, Boehm L,

and alternative communications. Macarthur C.

develop self-care activities in children with autism.

Duschenne-Smith J. Canadian Institutes of Health

Bell Canada ($150,000 2005-2007)

Mihailidis A, Roberts SW, Polatajko H, Chau T. SickKids Foundation ($129,470 2007-2009)

Research, National Sciences and Engineering Research Council of Canada and Social Sciences and

School, home and neighbourhood accessibility:

Humanities Research Council ($615,000 2005-2008)

physically disabled children’s assessments (The

The experience for autism over the course of paediatric

ScHaN Project). McKeever P, Ruddick S, Dunn J, Yantzi

development. Nicholas D, Roberts SW, McKeever P.

Long-term follow-up of boys with DMD.

N, Young N. Canadian Institutes of Health Research

SickKids Foundation ($129,821 2008-2010)

Leshner R, Biggar D. Co-operative International

($360,768 2008-2011) The experience of maternal and family care for

Neuromuscular Research Group Washington, DC ($400,000 2007-2012)

Strategic Training Program Grant for “Health Care,

autism over the course of paediatric development.

Technology and Place.” McKeever P, Coyte PC.

Nicholas D, Roberts SW, McKeever P. Social

Neuroimaging and frontal lobe function in children

Canadian Institutes of Health Research

Sciences and Humanities Research Council

with autism. Taylor M, Roberts SW, Donner EJ,

($2,146,250 2002-2009)

of Canada ($154,000 2008-2010)

The development and evaluation of the HAT-D: a

The lived experiences of mothers of children with

discriminative tool differentiating types of hypertonia

autism. Nicholas D, Roberts SW, McKeever P.

Outcomes research in paediatrics. Parkin P,

in children. Fehlings D, Jethwa A, Macarthur C.

Social Sciences and Humanities Research

Macarthur C. SickKids Foundation ($750,000 2008-2013)

Bloorview Research Institute ($9,606 2006-2007)

Council of Canada ($154,000 2008-2011)

Pain in infants with disabilities: a program of

The development of a virtual reality therapy home-

The paediatric hospital atrium: designers’ intentions

Bayless S, Shroff M. National Alliance Autism Research ($115,907 2006-2008)

research, phase II. Stevens B, McGrath P, Beyene J,

based system to improve hand usage and function

versus children’s experiences. Adams A, McKeever P,

Breau LM, Camfield CS, Finley GA, Gibbins S,

in children with hemiplegia. Fehlings D, Chau T,

Spalding K. Canadian Institutes of Health Research

Howlett A, Johnston C, McKeever P, O’Brien K,

Lam-Damji S, Tse K. Bloorview Research Institute

($291,376 2005-2008)

Ohlsson A. Canadian Institutes for Health Research

Seed Grant ($24,972 2006-2008)

($676,202 2003-2008)

52 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

The reliability and validity of the Paediatric Autism

Validation of accelerometry as a measure of physical

Early Diagnosis Tool (PAED) –a pilot project. Roberts W,

activity and inactivity in children with chronic diseases.

Green P, Shouldice M, Wright V. Bloorview Research

Feldman B, Stephens S, Schneidermna-Walker J,

Institute Seed Grant ($17,400 2006-2008)

Biggar WD, McCrindle B, Longmuir P. Canadian Institutes of Health Research ($60,000 2008-2009).

Training program in autism research. Fombonne E, Bryson S, Paterson A, Scherer S, Roberts W,

Western Canada standards of care for Duchenne

Szatmari P, Smith I, Moore C. Canadian Institutes

muscular dystrophy. Mah J, Moore M, Biggar WD.

of Health Research, National Alliance for Autism

Porticus Foundation ($23,125 2008)

Research, Fonds de la Recherche en Santé du Québec ($1,440,000 2003-2009)

Women’s income levels and diagnostic delay in breast cancer. Angus J, Bondy S, Paszat L, McKeever P.

Understanding chronic pain in infancy. Stevens BJ,

Social Sciences and Humanities Research Council

Asztalos E, McKeever P, Gibbins S, Pillai Riddell R,

of Canada ($90,620 2004-2007)

Katz J. Canadian Institutes of Health Research (2005-2008 $141,674)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 53

Dr. Mark Palmert

DIVISION HEAD Dr. Mark R. Palmert

Dr. Etienne Sochett Dr. Diane Wherrett

FULL-TIME Dr. Denis Daneman Dr. Jill Hamilton Dr. Kusiel Perlman

PART-TIME Dr. Jacqueline Curtis Dr. Susan Kirsch Dr. Stacey Urbach

GYNAECOLOGY Dr. Lisa Allen Dr. Nicolette Caccia Dr. Sari Kives Dr. Melanie Ornstein

GYNAECOLOGY FELLOW Dr. Kerith Lucco

HONORARY Dr. Robert Ehrlich

CROSS-APPOINTEES Dr. Amira Klip Dr. Joanne Rovet

SUBSPECIALTY RESIDENTS/ CLINICAL FELLOWS Dr. Abdulla Aljunaibi

Dr. Bojana Babic Dr. Corinna Grasemann Dr. Ara Healey Dr. Dror Koltin Dr. Clodagh O’Gorman Dr. Constantine Samaan

Division of Endocrinology OVERVIEW

Recent initiatives include the development of

HONOURS AND AWARDS

2007-08 was a highly productive time for the Division

pathways for the care of children with thyroid cancer

Allen L: University of Toronto Department of

of Endocrinology with ongoing development of existing

in collaboration with Oncology, Otolaryngology and

Obstetrics and Gynaecology Chairs’ Award for

programs and new innovations. We have had in 10

Nuclear Medicine; enhancement of our program

Excellence in Undergraduate Teaching, 2007.

trainees in our subspecialty training program: five

designed to provide care to survivors of paediatric

Canadian, two Irish, one Israeli, one Costa Rican

cancer who develop endocrine abnormalities; further

Hamilton J: NovoNordisk Young Investigator

and one from the UAE. We also welcomed Dr. Mark

development of our hypothalamic obesity program, with

Career Development Award, 2008.

Palmert as the new division head.

inclusion of a small number of patients with multiple

Our areas of clinical focus continue to be: (i) diabetes:

medical problems stemming from being overweight;

Hamilton J: The Hospital for Sick Children Department

and establishment of a new focus on disorders of puberty.

of Paediatrics Richard Rowe Junior Faculty Award for

our comprehensive program provides ongoing care

Excellence in Clinical Medicine, 2007.

to nearly 1,000 children and teens with diabetes,

Our research efforts have targeted the following

including a program for comprehensive assessment

areas: (i) prediction and prevention of Type 1 diabetes:

Klip A: Editor-in-chief–The American Journal

and treatment for adolescents with chronically

our group is involved in the multinational TrialNet

of Physiology–Endocrinology and Metabolism

poor diabetes control; (ii) general endocrinology

and TRIGR study groups; (ii) implications of insulin

Physiology, 2007.

emphasizing the areas of growth, thyroid disease,

resistance and obesity in children and adolescents

intersex conditions and reproductive health; (iii)

and the evolution of these abnormalities in young

Klip A: Glassman Lecturer, Hebrew University,

calcium: the Calcium-Bone and Osteoporosis Clinics

children; (iii) study of the factors affecting metabolic

Jerusalem, 2008.

assesses children with abnormal bone health from

control and the early complications of diabetes;

a wide variety of causes; and (iv) the gynaecology

(iv) psychosocial and psychological outcomes in

PUBLICATIONS

section; which provides care to pre-teen and

diabetes and other endocrine disorders; (v) evaluation

Aanstoot H-J, Anderson BJ, Daneman D, Danne T,

adolescent girls across a wide spectrum of disorders.

of disorders of calcium and bone mineral metabolism

Donaghue T, Kaufman F, Réa RR, Uchigata Y: The

in paediatrics. A new focus is clinical and laboratory

global burden of youth diabetes: perspectives and

based investigation of complex genetic traits, with an

potential, a charter paper. Pediatric Diabetes 2007:

emphasis on identification of genes that regulate the

8: pp 1-44.

timing of puberty.

SUBSPECIALTY RESIDENTS/ CLINICAL FELLOWS Dr. Rayzie Shulman Dr. Julieta Solis Chacon

RESEARCH FELLOWS Dr. Shazhan Amed Dr. Meranda Nakhla

ADMINISTRATIVE STAFF Joyce Robinson Elizabeth Rodgers Minet Smith Zarine Tilak

Díaz M, Antonescu CN, Capilla E, Klip A, Planas JV:

Allen L, Brewer M, Bryson P, Evans G, Frappier JY,

Cherney DZ, Miller JA, Scholey JW, Bradley T, Slorach C,

Jamieson MA, Lynde C, Murphy KJ, Provencher DM,

Curtis JR, Dekker MG, Nasrallah R, Hebert RL,

Fish glucose transporter (GLUT) -4 differs from

Shier M, Steben M, Lerch R, Lalonde A, Senikas V:

Sochett EB: The effect of cyclooxygenase 2 inhibition

rat GLUT-4 in its traffic characteristics but can

Canadian consensus guidelines on human

on renal hemodynamic function in humans with Type 1

translocate to the cell surface in response to insulin

papillomavirus. Obstetrics and Gynaecology Canada

diabetes. Diabetes 2008: 57 (3): pp 688-695.

in skeletal muscle cells. Endocrinology 2007: 148: pp 5248-5257.

2007: 29: pp S1-S59. Colton P, Olmsted M, Daneman D, Rydall A, Rodin G: Amed S, Delvin E, Hamilton J: Variation in growth

Five year prevalence and persistence of disturbed

Daneman A, Daneman D: McCune-Albright syndrome.

hormone immunoassays in clinical practice in Canada.

eating behaviour and eating disorders in girls with type

Journal of Pediatric Endocrinology and Metabolism

Hormone Research 2008: 69: pp 290-294.

1 diabetes. Diabetes Care 2007: 30: pp 2861-2862.

2007: 20: p 1265.

Antonescu CN, Díaz M, Femia G, Planas JV, Klip A:

Colton P, Olmsted M, Daneman D, Rydall A, Rodin G:

Dugani CB, Randhawa VR, Cheng AW, Patel N, Klip A:

Clathrin-dependent and independent endocytosis

Natural history and predictors of eating disturbances

Selective regulation of the perinuclear distribution of

of glucose transporter 4 (GLUT4) in myoblasts:

in girls with type 1 diabetes. Diabetic Medicine 2007:

glucose transporter 4 (GLUT4) by insulin signals in

regulation by mitochondrial uncoupling. Traffic 2008:

24: pp 424-429.

muscle cells. European Journal of Cell Biology 2008: 87(6): pp 337-351.

April 24 [Epub ahead of print]. Conwell L, Forrest C, Allen U, Daneman D: Necrotizing

Guilbert E, Broditsky R, Black A, Kives S, Leboeuf M,

Cameron FJ, Northam EA, Ambler GR, Daneman D:

fasciitis in adolescents with poorly controlled Type 1

Routine psychological screening in youth with type 1

diabetes mellitus: report of two cases. Pediatric

Mirosh M, Senikas V, Wagner MS, Weir E, York-Lowry J,

diabetes and their parents: a notion whose time has

Diabetes 2007: 8: pp 397-400.

Reid R, Trussell J: Canadian consensus guidelines on continuous and extended hormonal contraception.

come? Diabetes Care 2007: 30: pp 2716-2724. Conwell L, Pope E, Artiles A, Mohanta A, Daneman A,

Journal of Obstetrics and Gynaecology Canada 2007:

Daneman D: Dermatological complications of

29: pp S1-S32.

continuous subcutaneous insulin infusion (CSII) in children and adolescents. Journal of Pediatrics 2008: 152: pp 622-628.

56 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Hiraki LT, Hamilton J, Silverman ED: Measuring

Koltin D, Daneman D: Dead-in-bed syndrome –

Rachmiel M, Buccino J, Daneman D: Exercise

permanent damage in pediatric systemic lupus

a diabetes nightmare. Pediatric Diabetes 2008:

and type 1 diabetes mellitus in youth: review

erythematosus. Lupus 2007: 16: pp 657-662.

May 21 [Epub ahead of print].

and recommendations. Pediatric Endocrinology

Hodges CA, Palmert MR, Drumm ML: Infertility in

Makitie O, Toiviainen-Salo S, Marttinen E, Kaitila I,

females with cystic fibrosis is multifactorial: evidence

Sochett E, Sipila I: Metabolic control and growth

Rachmiel M, Kives S, Atenafu E, Hamilton J: Primary

from mouse models. Endocrinology 2008: 149(6):

during exclusive growth hormone treatment in X-linked

amenorrhea as a manifestation of polycystic ovarian

pp 2790-2797.

hypophosphatemic rickets. Hormone Research 2008:

syndrome in adolescents: a unique subgroup?

69(4): pp 212-220.

Archives of Pediatrics and Adolescent Medicine 2008:

Reviews 2007: 5: pp 656-665.

162: pp 521-525

HPV Consensus Guidelines Committee (Allen L, Brewer M, Bryson P, Evans G, Frappier JY, Jamieson MA,

Nadkarni D, Spitzer RF, Colgan T, Kives S, Allen L:

Lynde C, Murphy KJ, Provencher DM, Shier M,

Uterine asymmetry and dysmenorrhea in a young

Robertson D, Kives S: Adolescent consent in

Steben M, Lerch R, Lalonde A, Senikas V): Canadian

woman. Journal of Obstetrics and Gynaecology

reproductive and sexual health decision-making:

consensus guidelines on human papillomavirus.

Canada 2008: 30: pp 301-302.

should there be an arbitrary age of consent or should it be based on the “evolving capacities

Journal of Obstetrics and Gynaecology Canada 2007: 29: pp S1-S59. Ishikura S, Koshkina A, Klip A: Small G proteins in

O’Connor DL, Khan S, Wishuhm K, Vaughan J,

of the child”? Journal of Pediatric and Adolescent

Jefferies A, Campbell D, Asztalos E, Feldman M,

Gynaecology 2008: 21: pp 47-51.

Rovet J, Westall C, Whyte H: Growth and nutrient Roher N, Samokhvalov V, Díaz M, MacKenzie S, Klip A,

insulin action: rab and rho families at the crossroads

intakes of human milk-fed premature infants

of signal transduction and GLUT4 vesicle traffic. Acta

provided with extra energy and nutrients after

Planas JV: The proinflammatory cytokine tumour

Physiology 2008: 192: pp 61-74.

hospital discharge: a pilot randomized controlled

necrosis factor increases the amount of glucose

trial. Pediatrics 2007: 121: pp 766-776.

transporter-4 at the surface of muscle cells independently of changes in Interleukin-6. Endocrinology 2008: 149(4): pp 1880-1889.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 57

Segal P, Hamilton J, Sermer M, Connelly P, Hanley A,

Wells GD, Noseworthy MD, Hamilton J, Tein I:

Banerjee S, Tran K, Li H, Cimon K, Daneman D,

Zinman B, Retnakaran R: Maternal obesity and familial

Skeletal muscle dysfunction in obesity: new ideas

Simpson S, Campbell K: Short-acting insulin analogs

history of diabetes have opposing effects on infant

and concepts. Canadian Journal of Neurological

for diabetes mellitus: meta-analysis of clinical

birthweight in women with mild glucose intolerance in

Sciences 2008: 35: pp 31-40.

outcomes and assessment of cost-effectiveness

BOOKS AND BOOK CHAPTERS

Technologies in Health, Ottawa, 2007.

(Technology Report 87). Canadian Agency for Drug

pregnancy. Journal of Maternal-Fetal and Neonatal Medicine 2008: 21: pp 73-79.

Al-Abdulrazzaq D, Allen LM: Pediatric and adolescent Shulman DI, Francis GL, Palmert MR, Eugster EA,

gynecology. In: The Hospital for Sick Children

Caccia N, James A: Planned delivery by caesarean

for the Lawson Wilkins Pediatric Endocrine Society

Handbook of Pediatrics, 11th Edition. Elsevier,

section may be hazardous for mother and baby. In:

Drug and Therapeutics Committee: Use of aromatase

Canada, 2007.

AboutKidsHealth, www.aboutkidshealth.ca, 2008.

Allen LM. Management issues in child gynecology. In:

Hamilton J, Hozjan I: Lumps, bumps and other

Progress in pediatric Urology, Volume 10 (Pajpai M,

swellings: lymphatics and skin issues. In: Turner

inhibitors in children and adolescents with disorders of growth and adolescent development. Pediatrics 2008: 121(4): pp 975-983.

Gearhart JP, Mouriquand PDE, Mitra DK, Radhakrishan J,

Syndrome: Across the Lifespan. (Hamilton J, Hozjan I,

Spitzer R, Salle P, Wherrett D, Colgan T, Chitayat D,

Mathews R, Etker S, eds.). Penwel Publishers,

eds.). Castlemore Graphics, Brampton, Ontario, 2008.

Dodge J, Allen L: Luteoma of pregnancy presenting

New Delhi, 2008.

with virilization in the female infant. Journal of

Hamilton J, Hozjan I: Turner Syndrome: Across the

Obstetrics and Gynaecology Canada 2007: 29:

Amed S, Hamilton J: When sugar is not so sweet:

Lifespan. Castlemore Graphics, Brampton, Ontario, 2008.

pp 835-840.

diabetes and the metabolic syndrome. In: Turner Syndrome: Across the Lifespan (Hamilton J, Hozjan I,

Hodges CA, Palmert MR: Genetic regulation of the

Spitzer RF, Caccia N, Kives S, Allen LM: Hysteroscopic

eds.). Castlemore Graphics, Brampton, Ontario, 2008.

variation in pubertal timing. In: When Puberty is

unification of a complete obstructing uterine septum:

Precocious: Scientific and Clinical Aspects

Case report and review of the literature. Fertility and

(Pescovitz OH, Walvoord EC, eds.). Humana Press Inc.,

Sterility 2008: March 5 [Epub ahead of print].

Totowa, NJ, 2007.

58 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Kives S, Lacey J. Normal menstrual physiology.

Bypassing insulin resistance of muscle cells caused

Comparison of continuous versus cyclical use of a

In: Adolescent Health Care: A Practical Guide,

by ceramide, oxidative stress and macrophage-co-

30-MCG ethinyl estradiol 0.15 mg desogestrel oral

5th Edition (Neinstein LS, Gordon CM, Katzman DK,

culture. Klip A. Canadian Diabetes Association

contraceptive pill in adolescents. Allen L, Brown C.

Rosen DS, Woods ER, eds.). Lippincott Williams &

($300,000 2006-2009)

Physicians’ Services Incorporated Foundation ($75,000 2006-2008)

Wilkins, Philadelphia, 2007. Clinical Co-ordinating Centre for Epidemiology of Rovet J, Brown R. Congenital hypothyroidism. In:

Diabetes Intervention and Complications (DCCT/EDIC).

Cross-sectional study of overweight in paediatric

Neurogenetic Developmental Disorders: Manifestation

Palmert MR (Principal Investigator until August 2007;

survivors of acute lymphoblastic leukaemia. Nathan

and Identification in Childhood (Mazzocco M, Ross J,

now Consultant). National Institutes of Health/

PC, Urbach SL, Barrera M, Barron M, D’Agostino N,

eds.). MIT Press, Boston, 2007.

National Institute of Diabetes and Digestive and

Staneland P, Charron, Greenberg ML. The University

Kidney Diseases ($54,312,694 2006-2016)

of Toronto, Faculty of Medicine Dean’s Fund ($9,998 2007-2008)

Tran K, Banerjee S, Li H, Cimon K, Daneman D, Simpson S, Campbell K. Long-acting insulin analogues

Combined diazoxide and metformin therapy in

for diabetes mellitus: meta-analysis of clinical

children with hypothalamic obesity secondary

Evaluation of hepatic function and autoimmunity in

outcomes and assessment of cost-effectiveness.

to craniopharyngioma: a pilot study. Hamilton J,

girls with Turner Syndrome. Hamilton J, McAssey K,

Canadian Agency for Drugs and Technologies in

Daneman D, Ahmet A. Canadian Institutes of

Milkiewicz P, Heathcote J, Norman G (Investigator

Health, Ottawa, 2007.

Health Research ($49,500 2006-2008)

initiated study). Hoffman-La Roche Canada ($23,980 2006-2008)

FUNDING

Comparison of continuous versus cyclic use of a

A phase IV open-label study of predictive markers in

30-MCG ethinyl estradiol 0.15 mg desogestrel oral

Genetic factors that regulate the onset of puberty.

growth hormone deficient and Turner Syndrome

contraceptive pill in adolescents. Allen L, Brown C.

Palmert MR. National Institutes of Health/National

pre-pubertal children treated with SAIZEN. Hamilton J

Azko Nobel – Organon Canada ($24,500 2006-2008)

(Principal Investigator SickKids site). Serono Canada

Institute of Child Health and Human Development ($1,633,256 2005-2010)

Incorporated ($2,400 2005-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 59

Growth hormone therapy and bone quality in

Intracellular compartment plasticity and signal

Post-marketing surveillance program for Nutropin.

paediatric osteoporosis. Sochett E, Grynpas M. Eli

transmission in insulin action. Klip A. Canadian

Hamilton J. Genentech National Co-operative Growth

Lilly Canada ($125,000 2006-2009)

Institutes of Health Research ($759,560 2005-2010)

Study (NCGS) ($45,300 2001-2008)

Hemodynamic modulation in type 1 diabetes. Miller J,

MRI analyses of visuospatial processing deficits

Psychosocial adjustment in genetic males born with

Sochett E, Cherney D. Canadian Institutes of Health

in children born preterm. Rovet J, Desrocher M,

ambiguous genitalia. Wherrett DK. The Hospital for

McAndrews MP. March of Dimes

Sick Children Research Institute Seed Grant

(US$335,945 2007-2010)

($15,590 2001-2008)

for glucose transport. Klip A. Canadian Institutes of

Multiple courses of antenatal corticosteroids for

The comprehensive care clinic for children with central

Health Research ($643,800 2002-2007)

preterm birth study: a five-year follow-up (MACS-5).

tumours at The Hospital for Sick Children: evaluating

Asztalos E, Rovet J. Canadian Institutes of Health

the efficacy of an integrated, multidisciplinary model

Research ($3,585,161 2005-2012)

of care for children with hypothalamic dysfunction.

Research ($105,000 2007-2012) Hormonal regulation of p38MAPK and its implications

Insulin resistance and beta cell dysfunction in early

Hamilton J, Barrera M, Guger S, Popov T, Schulte F.

childhood: the role of maternal and infant metabolic National surveillance of non-type 1 diabetes mellitus

Brain Tumour Research Assistance and Information

Zinman B. Canadian Institutes of Health Research

in Canadian children. Hamilton J, Dean H, Amed S,

Network (b.r.a.i.n. Child) ($27,931 2006-2008)

($341,706 2005-2008)

Sellers E, Dannenbaum D, Laubscher L, Booth G.

risk factors. Hamilton J, Hanley A, Retnakaran R,

Canadian Diabetes Association ($97,939 2006-2008)

The genetics and neuroendocrinology of short stature. Hamilton J (Principal Investigator SickKids site).

Insulin sensitization by muscle contraction pathways: implications for insulin resistance. Klip A. Canadian

Neuroimaging studies of hippocampal formation in

Lilly International Growth Study (GeNeSIS)

Institutes of Health Research and National Science

children with pre- and post-natal thyroid hormone

($58,542 2002-2008)

Foundation of China - China-Canada Joint Health

insufficiencies. Rovet J, Desrocher M, McAndrews MP,

Research Initiative ($90,000 2006-2009)

Sheard E. Canadian Institutes of Health Research ($728,640 2006-2011)

60 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

The GH Monitor Registry. Hamilton J (Principal

Treatment options for Type 2 diabetes in adolescents

Investigator SickKids site). Serono Canada

and youth (TODAY). Palmert MR (Principal Investigator

Incorporated ($6,200 2008-2010)

until August 2007), Dahms W. National Institutes of

The GLUT4 interactomes and their metabolic

and Kidney Diseases ($3,240,000 2002-2010)

Health/National Institute of Diabetes and Digestive implications. Klip A. Canadian Institutes of Health Research ($818,206 2007-2012)

Type 1 diabetes TrialNet–the impact of GAD on preservation of cell function. Wherrett DK. National

Thyroid hormone insufficiencies and visual perceptual

Institutes of Health (US$450,000 2007-2008)

deficits in preterm infants. Rovet, J, Westall C, Asztalos E, Perlman K, Heon E. March of Dimes

Type 1 diabetes genetics consortium. Wherrett DK.

(US$253,083 2004-2007)

National Institutes of Health contract with Benaroya Research Institute (US$15,000 2003-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 61

Dr. Peter Durie

DIVISION HEAD Dr. Stanley Zlotkin FULL-TIME Dr. Peter Durie Dr. Nicola Jones

Dr. Dr. Dr. Dr. Dr. Dr.

Anne Griffi ths Simon Ling Vicky Ng Paul Pencharz Philip Sherman Mary Zachos

PART-TIME Dr. Glenn Berall Dr. Carol Durno Dr. Paul Kortan Dr. Margaret Marcon Dr. Gary May

CROSS-APPOINTEES Dr. Mary Corey CLINICAL FELLOWS Dr. Fatma Al-Madhaki Dr. Tanja Gonska Dr. Keith Ooi Dr. Juan Ossa

RESEARCH FELLOWS Dr. Eric Benchimol Dr. Juan Gana Dr. Orlee Guttman Dr. Seamus Hussey Dr. Aleixo Muise Dr. Mary Sherlock

Dr. Dan Turner Dr. Catharine Walsh Dr. Thomas Walters Dr. Eytan Wine Dr. Jason Yap

Division of Gastroenterology, Hepatology and Nutrition OVERVIEW

This year, staff and fellows in the division have

Benchimol E: Trainee Scholarship,

The Division of Gastroenterology, Hepatology and

been honoured with awards, fellowships and named

Gastroenterology Research Group and The American

Nutrition is one of the only programs in Canada with a

lectureships, including Canadian Association of

Gastroenterological Association Institute, 2007.

fully integrated specialty program in clinical paediatric

Gastroenterology Visiting Professorship, Fellow of

GI, hepatology, transplantation (liver and small bowel)

the American Society of Nutrition, the Joseph M. West

Gana J: Canadian Child Health Clinician Scientist

and nutrition, and vertical programs in education and

Family Memorial Award, the Levy/Thomson Award for

Program Career Enhancement Program Award, 2008.

research which span the clinical spectrum. The

Outstanding Oral Presentation, the Miriam Neveren

program offers one year of clinical training and two

Memorial Award, the Canadian Child Health Clinician

Gana J: Levy/Thomson Award for Outstanding Oral

research years. The clinical component includes a wide

Scientist Program (CCHCSP) Career Enhancement

Presentation. Gana JC, Roberts EA, Ng VL, Ling SC.

array of experiences including: procedures (endoscopy,

Program Award, and many more. The staff members

Non-invasive diagnosis of esophageal varices in

manometry and calorimetry), inpatient management of

of the division have published over 60 peer-reviewed

children. Gastroenterology residents-in-training (GRIT)

complex patients, including those awaiting and

publications, nine books or book chapters and have

as part of the Canadian Digestive Diseases Week

undergoing transplantation, those with inflammatory

received well over $10 million of grant funding for

(CDDW), Montreal, 2008.

bowel disease and more; ambulatory clinics (including

projects spanning the next five years.

home TPN, dysphasia, general GI, IBD, hepatology,

Guttman O: CASL/Schering-Plough Canada

transplantation and nutrition); and evidence-based

HONOURS AND AWARDS

educational rounds and training in ethics and

Benchimol E: Canadian Child Health Clinician-Scientist

communication. Our research spans the spectrum from

Program Doctoral Award, 2008.

Hussey S: The CAG/CIHR/CCFC Fellowship, 2008-2010.

as inflammatory bowel disease, pancreatic diseases,

Benchimol E: The Hospital for Sick Children Clinician-

Hussey S: The Chisholm Memorial Fellowship, 2008.

ulcer disease, liver diseases, GI microbiology and

Scientist Training Program Research Fellowship, 2007.

Hepatology Fellowship, 2007.

basic and translational to patient-based in such areas

immunology, nutritional metabolism and nutrient

Hussey S: The Elizabeth Arbuthnot Dyson

requirements. Many of our trainees in the research

Benchimol E: Joseph M. West Family Memorial Fund,

Fellowship, 2008.

program (two years) combine a formal degree-granting

Department of Post-Graduate Medical Education,

program at the University of Toronto (M.Sc. or PhD)

University of Toronto, 2007.

Hussey S: The Miriam Neveren Memorial Award, 2008.

our fellows have gone on to very successful careers in

Benchimol E: American College of Gastroenterology

Hussey S: The Edward Christie Stevens Fellowship, 2008.

academic paediatric gastroenterology.

Clinical Research Award, 2007.

within their research fellowship years. The majority of

SUBSPECIALTY RESIDENTS Dr. Kesete Bezu ADMINISTRATIVE STAFF Chona Callejo Roxanne Francis

Margaret Johnson Sherry Joy Nnenna Ngoka Lilatool Shakur Suzanne Shek

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 63

Ling SC: Paediatric Transplant Bursary Award,

Wine E: Canadian Institute of Health Research/

Barr R, Atkinson S, Pencharz P, Arguelles GR: Nutrition

Canadian Transplant Society. Paediatric liver

Canadian Association of Gastroenterology/Industry

and cancer in children. Pediatric Blood and Cancer

transplantation: 20-year experience at The Hospital

(Astra Zeneca) Research Initiative Award, 2007.

2008: 50(S2): p 437.

for Sick Children. Canadian Society of Transplantation

PUBLICATIONS

Barron MA, Pencharz PB: Nutritional issues in infants

Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S,

with cancer. Pediatric Blood and Cancer 2007:

Pencharz P: Fellow of the American Society

Briend A, Dewey KG: Randomized comparison of

49(S7): pp 1093-1096.

for Nutrition, 2008.

three types of micronutrient supplements for home

Annual Meeting, Mont-Tremblant, Quebec, 2008.

fortification of complementary foods in Ghana:

Beck P, Shaffer E, Gall D, Sherman PM: The natural

Sherman P: Canada Research Chair, Tier 1

effects on growth and motor development. American

history and significance of ultrasonographically

(renewal), 2008.

Journal of Clinical Nutrition 2007: 86: pp 412-420.

defined polypoid lesions of the gallbladder in children. Journal of Pediatric Surgery 2007: 42: pp 1907-1912.

Sherman P: Canadian Association of Gastroenterology

Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG: Home fortification of

Bellissimo N, Desantadina V, Pencharz PB, Berall GB,

complementary foods with micronutrient supplements

Thomas SG, Anderson GH: A comparison of short-term

Wine E: Canadian Child Health Clinician Scientist

is well accepted and has positive effects on infant

appetite and energy intakes in weight and obese boys

Program (CCHCSP) Career Enhancement Program

iron status in Ghana. American Journal of Clinical

following glucose and protein drinks. International

Award, 2007.

Nutrition 2008: 87: pp 929-938.

Journal of Obesity 2008: 32: pp 362-336.

Visiting Professor Award, 2008.

Wine E: The Hospital for Sick Children Clinician

Ball RO, Urschel KL, Pencharz PB: Nutritional

Bellissimo N, Pencharz PB, Berall GB, Goode RC,

Scientist Training Program (CSTP), 2007.

consequences of interspecies differences in arginine

Thomas SG, Anderson GH: Effect of television viewing

and lysine metabolism. Journal of Nutrition 2007: 137:

at mealtime on food intake after a glucose preload

pp 1626S-1641S.

in boys. Pediatric Research 2007: 61: pp 745-749.

Wine E: The University of Toronto Faculty of Medicine, Postgraduate Award (Javenthey Soobiah, Charles Fell Charitable Trust, Chisholm Memorial Fellowship Joseph M. West Family Memorial Fund), 2007.

64 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Bellissimo N, Pencharz PB, Berall GB, Goode RC,

Castellani C, Cuppens H, Macek Jr M, Cassiman JJ,

Draper H, Diamond IR, Temple M, John P, Ng VL,

Thomas SG, Anderson GH: Reproducibility of short-

Kerem E, Durie P, Tullis E, Assael BM, Bombieri C,

Fecteau A: Multimodal management of endangering

term food intake and subjective appetite scores after

Brown A, Casals T, Claustress M, Cutting GR,

hepatic hemangioma impact on transplant avoidance.

a glucose preload, ventilation threshold and body

Dequeker E, Dodge J, Doull I, Farrell P, Ferec C,

Journal of Pediatric Surgery 2008: 43: pp 120-126.

composition in boys. Applied Physiolology and

Girodon E, Johannesson M, Kerem B, Knowles M,

Nutrition Metabolism 2008: 33: pp 326-337.

Munck A, Pignatti PF, Radojkovic D, Rizzotti P, Schwarz

Elango R, Ball RO, Pencharz PB: Indicator amino

M, Stuhrmann M, Tzetis M, Zielenski J, Elborn JS:

acid oxidation: concept and application. Journal

Benchimol E, Kirsch R, Viero S, Griffiths AM:

Consensus on the use and interpretation of cystic

of Nutrition 2008: 138: pp 243-246.

Collagenous colitis and eosinophilic gastritis in a

fibrosis mutation analysis in clinical practice. Journal

four-year old girl: a case report and review of the

of Cystic Fibrosis 2008: 7: pp 179-196.

Elango R, Ball RO, Pencharz PB: Individual amino acid requirements in humans: an update. Current Opinion

literature. Acta Paediatrica 2007: 96: pp 1365-1367.

in Nutrition and Metabolic Care 2008: 11: pp 34-39.

Dassopoulos T, Nguyen GC, Sitton A, Bromfiled GP, Benchimol EI, Seow CH, Steinhart AH, Griffiths AM:

Schumm LP, Wu Y, Riguiero M, Siemanowski B,

Traditional corticosteroids for induction of remission

Griffiths AM, Brant S, Rious JD, Yang H, Duerr RH,

Elango R, Humayun MA, Ball RO, Pencharz PB: Lysine

in Crohn’s disease. Cochrane Database System

Silverberg M, Cho JH, Steinhart H: Assessment of

requirement of healthy school-age children determined

Review 2008: 2: CD006792.

reliability and validity of IBD phenotyping within the

by indicator amino acid oxidation method. American

NIDDK IBD genetics consortium (IBDGC).

Journal of Clinical Nutrition 2007: 86: pp 360-365.

Benchimol EI, Turner D, Mann EH, Thomas KE,

Inflammatory Bowel Diseases 2007: 13: pp 975-983. Gao Y, Sherman PM, Sun Y, Li D: Multiplexed

Gomes T, McLernon RA, Griffiths AM: Toxic megacolon in children with inflammatory bowel disease: clinical

Dorfman R, Sandford A, Taylor C, Huang B,

high-throughput electrokinetically-controlled

and radiographic characteristics. American Journal of

Frangolias D, Wang Y, Sang R, Pereira L, Sun L,

immunoassay for the detection of specific bacterial

Berthiaume Y, Tsui L-C, Paré PD, Durie P, Corey M,

antibodies in human serum. Analytica Chimica Acta

Zielenski J: Complex two-gene modulation of lung

2008: 606: pp 98-107.

Gastroenterology 2008: May 26 [Epub ahead of print].

disease severity in children with cystic fibrosis. Journal of Clinical Investigation 2008: 118: pp 1040-1049.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 65

Gareau M, Jury J, MacQueen G, Sherman PM,

Humayun MA, Elango R, Moehn S, Ball RO,

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH,

Perdue M: Probiotic treatment of rat pups normalizes

Pencharz PB: Application of the indicator amino acid

Rioux RD, Brant SR, Silverberg MS, Taylor KD,

corticosterone release and ameliorates colonic

oxidation technique for the determination of metabolic

Barmada MM, Bitton A, Dassopoulos T, Datta LW,

dysfunction induced by maternal separation. Gut

availability of sulphur amino acids from casein versus

Green T, Griffiths AM, Kistner EO, Murtha MT,

2007: 56: pp1522-1528.

soy protein isolate in adult men. Journal of Nutrition

Regueiro MD, Rotter JI, Schumm LP, Steinhart AH,

2007: 137: pp 1874-1879.

Targan SR, Xavier R, the NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M,

Green GJ, Weitzman SS, Pencharz PB: Resting energy expenditure in children with stage IV neuroblastoma.

Hussey S, Terebiznik MR, Jones NL: Autophagy: healthy

Belaiche J, Dewit O, Gut I, Heath S, Laukens D,

Pediatric Research 2008: 63: pp 332-336.

eating and self digestion for gastroenterologists.

Mni M, Rutgeerts P, Van Gossum A, Zelenika D,

Heuschkel R, Salvestrini C, Beatties RM, Hildebrand H,

Journal of Pediatric Gastroenterology, Hepatology,

Franchimont D, Hugot JP, de Vos M, Vermeire S,

Nutrition 2008: 46: pp 496-506.

Louis E, the Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E,

Walters T, Griffiths AM: Guidelines for the management of growth failure in childhood

Ip H, Hyder Z, Haseen F, Rahman M, Zlotkin S:

Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Ghori J,

inflammatory bowel disease. Inflammatory Bowel

Improved adherence and anemia cure rates with

Bumpstead S, Gwillam R, Tremelling M, Deloukas P,

Diseases 2008: 14: 839-849.

flexible administration of micronutrient Sprinkles:

Mansfield J, Jewell D, Satsangi J, Mathew CG,

a new public health approach to anaemia control.

Parkes M, Georges M, Daly MJ. Genome-wide

Humayun MA, Elango R, Ball RO, Pencharz PB: A

European Journal of Clinical Nutrition 2007:

association defines more than 30 distinct

re-evaluation of protein requirement in young men using

September 26 [Epub ahead of print].

susceptibility loci for Crohn’s disease. Nature

the indicator amino acid oxidation technique. American Journal of Clinical Nutrition 2007: 86: pp 995-1002.

66 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Genetics 2008: June 29 [online publication].

Johnson-Henry K, Donato K, Gordanpour M,

Lenoir-Wijnkoop I, Sanders M, Cabana M, Caglar E,

Mager D, Marcon M, Wales P, Pencharz PB: Use

Sherman PM: Lactobacillus rhamnosus strain GG

Corthier G, Rayes N, Sherman PM, Timmerman H,

of N-acetyl cysteine for the treatment of parenteral

prevents enterohemorrhagic Escherichia coli-induced

Vaneechoutte M, Van Loo J, Wolvers D: Probiotic

nutrition (PN) induced liver disease in children on

changes in epithelial barrier function. Infection and

and prebiotic influence beyond the intestinal tract.

home PN. Journal of Pediatric Gastroenterology

Immunity 2008: 76: pp 1340-1348.

Nutrition Reviews 2007: 65: pp 469-489.

and Nutrition 2008: 46: pp 220-223. Moehn S, Bertolo RFP, Martinazzo-Dallagnol E,

Kappelman M, Bousvaros A, Hyams J, Markowitz J,

Lewis K, Caldwell J, Phan V, Prescott D, Nazli A,

Griffiths AM and the Pediatric IBD Registry Group:

Wang A, Soderholm J, Perdue M, Sherman PM,

Pencharz PB, Ball RO: Metabolic availability of lysine

Variation in the initial management of children with

McKay D: Decreased epithelial barrier function evoked

in feedstuffs determined using oral isotope delivery.

Crohn’s disease. Inflammatory Bowel Diseases 2007:

by exposure to metabolic stress and non-pathogenic E.

Livestock Science 2007: 109: pp 24-26.

13: pp 890-895.

coli is enhanced by TNFα. American Journal of Physiology 2008: 294: pp G669-G678.

Muise AM, Walters TD, Wine E, Griffiths AM, Turner D,

Griffiths AM, Bousvaros A, Hyams J: Body mass index

Ling SC: Congenital cholestasis syndromes: what

Silverberg MS, Rotin D: Protein tyrosine phosphatase

in children with newly diagnosed inflammatory bowel

happens when children grow up? Canadian Journal

sigma is associated with ulcerative colitis. Current

disease: observations from two multicentre North

of Gastroenterology 2007: 21: pp 743-751.

Biology 2007: 17: 1212-1218.

Madore A-M, Prevost C, Dorfman R, Taylor C, Durie P,

Nasr A, Avitzur Y, Ng VL, De Silva N, Wales PW: The

Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM,

Kugathasan S, Nebel J, Skelton J, Markowitz J, Keljo D,

American inception cohorts. Journal of Pediatrics 2007: 151: pp 523-527.

Zielenski J, Laprise C: Distribution of CFTR mutations

use of conjugated hyperbilirubinemia greater than 100

Leach ST, Mitchell HM, Geczy CL, Sherman PM, Day AS:

in Saguenay-Lac-Saint-Jean: proposal of a panel of

lmol/L as an indicator of irreversible liver disease in

S100 calgranulin proteins S100A8, S100A9 and

mutations for population screening. Genetics in

infants with short bowel syndrome. Journal of

S100A12 are expressed in the inflamed gastric mucosa

Medicine 2008: 10: pp 201-206.

Pediatric Surgery 2007: 42: pp 359-362.

of helicobacter pylori-infected children. Canadian Journal of Gastroenterology 2008: 22: pp 461-464.

Ng VL, Anand R, Martz K, Fecteau A: Liver retransplantation in children: SPLIT database analysis of outcome and predictive factors for survival. American Journal of Transplantation 2008: 8: pp 386-395.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 67

Ng VL, Otley AR: Understanding quality of life for

Pencharz PB: Assessment of protein nutritional status.

children after liver transplantation: a work in progress.

Pediatric Blood and Cancer 2008: 50(S2): pp 445-446.

Rosh JR, Gross T, Mamula P, Griffiths AM, Hyams J: Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn’s disease: a cautionary tale.

Liver Transplantation 2008: 14: pp 415-417. Puntai J, Markowitz J, Lerer T, Hyams J, Kugathasan S, O’Shea A-M, Wilson G, Ling SC. Minassian B, Cutz E:

Griffiths AM, Otley A, Crandall W, the Pediatric IBD

Lafora-like ground glass inclusions in hepatocytes of

Collaborative Research Group: The effect of early

Inflammatory Bowel Diseases 2007: 13: pp 1024-1030. Samonte V, Sherman PM, Taylor G, Carricato M,

paediatric patients–report of two cases. Pediatric and

immunomodulator use in moderate to severe pediatric

Fecteau A, Ling S, Ng V: Scurvy diagnosed in a

Developmental Pathology 2007: 10: pp 351-357.

Crohn disease. Inflammatory Bowel Diseases 2008:

pediatric liver transplant patient awaiting combined

February 17 [Epub ahead of print].

kidney and liver retransplantation. Pediatric Transplantation 2008: 12: pp 363-367.

Panaccione R, Fedorak R, Aumais G, Bernard E-J, Bernstein CN, Bitton A, Croitoru K, Dieleman LA,

Rafii M, Elango R, Courtney-Martin G, House J, Fisher L,

Enns R, Feagan BG, Franchimont D, Greenberg GR,

Pencharz PB: High-throughput and simultaneous

Griffiths AM, Marshall J, Pare P, Patel S, Penner R,

measurement of homocysteine and cysteine in

to measure resting energy expenditure in clinical

Render C, Seidman E, Steinhart AH: Review and

human plasma and urine by liquid chromatography-

practice in children. Journal of Pediatrics 2008:152:

clinical perspectives for the use of infliximab in

electrospray tandem mass spectrometry. Analytical

pp 437-439.

ulcerative colitis. Canadian Journal of

Biochemistry 2007: 371: pp 71-81.

Shakur YA, Richards H, Pencharz PB: Is it necessary

Sharieff W, Dofonsou J, Zlotkin S. Is cooking food in

Gastroenterology 2008: 22: 261-272. Rafii M, McKenzie JM, Roberts SA, Steiner G, Ball RO,

iron pots an appropriate solution for the control of

Pencharz P: Energy balance and body composition.

Pencharz PB: The in vivo regulation of phenylalanine

anaemia in developing countries? A randomized clinical

Pediatric Blood and Cancer 2008: 50: p 468.

hydroxylation using enrichment in Apo-B 100. American

trial in Benin. Public Health Nutrition 2007: 15: pp 1-7.

Journal of Physiology 2008: 294: pp E475-E479. Pencharz PB, Hsu JW, Ball RO: Aromatic amino acid requirements in healthy human subjects. Journal of Nutrition 2007: 137: pp 1576S-1578S.

68 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Urschel KL, Rafii M, Pencharz PB, Ball RO: A multi-

Shugart YY, Silverberg MS, Duerr RH, Taylor KD,

Turner D, Grossman A, Rosh J, Gilman AR,

Wang MH, Zarfas K, Schumm LP, Bromfielf G,

Kugathasan S, Baladassano R, Griffiths AM:

tracer stable isotope quantification of the effects of

Steinhart AH, Griffiths AM, Kane SV, Barmada MM,

Methotrexate following unsuccessful thiopurine

arginine intake on whole-body arginine metabolism in

Rotter JI, Mei L, Bernstein CN, Bayless TM, Langelier D,

therapy in pediatric Crohn’s disease. American Journal

neonatal piglets. American Journal of Physiology

Cohen A, Bitton A, Rioux JD, Cho JH, Brant SR:

of Gastroenterology 2007: 102: pp 2804-2812.

2007: 293: pp E811-E818.

An SNP linkage scan identifies significant Crohn’s disease loci on chromosomes 13q13.3 and, in Jewish

Turner D, Otley AR, Mack D, Hyams J, de Bruijne J,

Wallon C, Yang PC, Keita A, Ericson AC, McKay DM,

families, on 1p35.2 and 3q29. Genes and Immunity

Uusoue K, Walters TD, Zachos M, Mamula P,

Sherman PM, Perdue MH, Soderholm JD: Corticotropin-

2008: 9: pp 161-167.

Beaton DE, Steinhart AH, Griffiths AM: Development,

releasing hormone (CRH) regulates macromolecular

validation, and evaluation of pediatric ulcerative

permeability via mast cells in normal human colonic

Toiviainen-Salo S, Raade M, Durie PR, Ip W, Marttinen E,

colitis activity index: a prospective multicentre study.

biopsies in vitro. Gut 2008: 57: pp 50-58.

Savilahti E, Makitie O: MRI findings of the pancreas in

Gastroenterology 2007: 133(2): pp 423-432. Ward LM, Gaboury I, Ladhani M, Zlotkin S: Vitamin

patients with Shwachman-Diamond syndrome and mutations in the SBDS gene. Journal of Pediatrics

Turner D, Steinhart AH, Griffiths AM: Omega-3 fatty

D-deficiency rickets among children in Canada. Canadian

2008: 152: pp 434-436.

acids (fish oil) for maintenance of remission in

Medical Association Journal 2007: 177: pp 161-166.

ulcerative colitis. Cochrane Database System Turner D, Griffiths AM: Esophageal, gastric and

Wilschanski M, Durie PR: Patterns of GI disease in

Review 2007: CD006443.

adulthood associated with mutations in the CFTR

duodenal manifestations of IBD, and the role of upper endoscopy in IBD diagnosis. Current Gastroenterology

Turner D, Walsh CM, Benchimol EI, Mann EH,

Reports 2007: 9: pp 475-478.

Thomas KE, Chow C, McLernon RA, Walters TD,

gene. Gut 2007: 56: pp 1153-1163.

Steinhart AH, Griffiths AM: Severe paediatric ulcerative

Zlotkin S: Editorial - ‘Control of Anemia: the time to act

colitis: incidence, outcomes, and optimal timing for

is now’. Indian Pediatrics 2007: 44: pp 84-86.

second line therapy. Gut 2008: 57: pp 331-338.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 69

BOOKS AND BOOK CHAPTERS

Wallace J, Sherman PM: Resolution of mucosal

A multi-disciplinary human study on the genetic,

Anemia Review Panel: anaemia Guidelines for Family

inflammation. In: Progress in Inflammation Research

environmental and microbial interactions that cause

Medicine, 2nd Edition. MUMS Guideline Clearinghouse,

Series: Resolution of Inflammation (Rossi A,

IBD. Croitoru K, Griffiths AM, Ropelski M, Moyeddi P.

Toronto, 2008.

Sawatsky D, eds.) Berkhauser Verlag AG, Basel, 2007.

Crohn’s and Colitis Foundation of Canada ($5,600,000 2007-2012)

Durie PR: Schwachman-Diamond Syndrome. In:

Walters TR, Griffiths AM: Growth impairment in IBD.

Pediatric Gastrointestinal Disease, 5th Edition,

In: Pediatric Inflammatory Bowel Disease (Baldassano

A novel candidate susceptibility gene at the IBD6

Volume 2 (Kleinman RE, Sanderson IR, Goulet O,

R, Mamula P, Markowitz J, eds.). Springer, USA, 2008.

locus. Griffiths AM, Rotin D. Crohn’s and Colitis Foundation of Canada New Innovations Grant

Sherman PM, Mieli-Vergani G, Shneider BL, eds.). BC Decker Inc., Hamilton, 2008.

Wine E, Terebiznik M, Jones NL: Microbial interactions

($50,000 2007)

with gut epithelium. In: Paediatric Gastrointestinal Disease, 5th Edition, Volume 1 (Kleinman R, Goulet O,

A prospective study of linear growth in paediatric

in inflammatory bowel disease. In: Pediatric

Mieli-Vergnani G, Sherman P, Schneider B, eds.).

IBD. Denson LA, Griffiths AM. Crohn’s and Colitis

Nutrition in Practice (Berthold K, ed.) Karger,

BC Decker Inc., Hamilton, 2008.

Griffiths AM, Carricato M: Enteral nutrition

Basel, Switzerland, 2008.

Foundation of America ($150,000 per year 20072010)

FUNDING Griffiths AM, Hugot J-P: Crohn’s disease. In: Paediatric

A multicentre study of the safety and efficacy of

Adalimumab in pediatric Crohn’s disease: a multicentre

Gastrointestinal Disease, 5th Edition, Volume 1

N-acetylcysteine in the treatment of acute liver failure

study. Griffiths AM. Abbott Laboratories (per patient

(Kleinman R, Goulet O, Mieli-Vergnani G, Sherman P,

in paediatric patients not caused by acetaminophen.

remuneration; anticipated $90,000 2007-2009)

Schneider B, eds.). BC Decker Inc., Hamilton, 2008.

Ng VL, Fecteau A. National Institutes of Health/ National Institute of Diabetes and Digestive and Kidney Diseases (US$69,000 2005-2010)

70 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Arginine and CF. Grasemann H, Ratjen F,

Development and validation of a disease-specific

Epidemiology of eosinophilic esophagitis in children

Pencharz P. Canadian Cystic Fibrosis Foundation

health-related quality of life questionnaire for children

and adolescents in Canada. Marcon MA, Dourin E.

($140,000 2007-2010)

after liver transplantation. Otley AR, Ng VL, Nicholas

Directing study which involves all 16 paediatric

Assessment of activity and prediction of outcome in

DB, Thompson J, Gilmour S, Watters C. Canadian

centres in Canada. J. Campbell Fund ($62,966

Institutes of Health Research ($280,576 2005-2009)

2006-2008)

paediatric ulcerative colitis. Turner D, Steinhart H, Griffiths AM. Canadian Association of

Development and validation of an objective skill

Evaluation of a novel parenteral lipid source in the

Gastroenterology/Canadian Institutes of Health

assessment for colonoscopy. Ling SC, Walsh C.

prevention of PN associated cholestasis. Wales P,

Research ($65,000 per year 2006-2008)

The Hospital for Sick Children Paediatric

Pencharz P. Fresenius-Kabi ($159,850 2008)

Consultants Partnership ($4,968 2007) Evaluation of CFTR function ex-vivo in sweat glands

Cell signals: cell signalling in mucosal inflammation

of perfused skin as a translational tool for future drug

and pain. Ellen R, Jones NL. Canadian Institutes

Development of a new sweat test using sweat

of Health Research ($300,000 2002-2008)

potential measurements. Durie PR. Cystic Fibrosis

trials in CF. Durie PR, Pang C, Bear CE, Gonska T.

Foundation Therapeutics, Inc. ($70,818 US 2008)

(SickKids) Research Institute, New Ideas Grant ($50,000 2008-2009)

Clinical Research Facilitation Award. Durie PR. Cystic Fibrosis Foundation Therapeutics, Inc.

Development of a piglet short gut model. Turner J,

(US$108,280 2007-2008)

Ball R, Pencharz P, Wales P. Stollery Children’s

Food intake control in children. Anderson GH,

Hospital Foundation ($29,223 2007)

Berall GB, Goode RC, Pencharz PB. Canadian Institutes of Health Research ($104,219 2007-2010)

Clinician scientist training program in clinical nutrition research. Pencharz P. Canadian Institutes of Health

Diagnosing cystic fibrosis in neonates and adults:

Research ($265,000 2002-2008)

where do we draw the line? Durie PR, Tullis E, Ratjen F. Canadian Cystic Fibrosis Foundation

transplantation. Ng VL, Fecteau A. National Institutes

Determining the threshold of CFTR function that

($120,000 per year 2008-2011)

of Health/National Institute of Diabetes and

causes CF disease. Durie PR. Canadian Cystic

Functional outcomes after paediatric liver

Digestive and Kidney Diseases (US$6,000 2007-2008)

Fibrosis Foundation ($110,000 per year 2005-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 71

Genetic predictors of time to recurrence following ileal

Innovative strategies for optimizing management

North American IBD Genetics Consortium. Cho J,

resection in early onset Crohn’s disease. McLeod R,

of infants with biliary atresia. Guttman O

Duerr R, Silverberg M, Griffiths AM, Rotter J,

Griffiths AM. Crohn’s and Colitis Foundation

(co-supervisors: Ng VL, Roberts EA.) Canadian

Brandt S, Rioux J. National Institutes of Health

of Canada ($150,000 per year 2007-2010)

Association for the Study of Liver Disease/

($3,000,000 2007-2011)

Canadian Institutes of Health Research Host responses to Helicobacter pylori infection:

Fellowship Award ($55,000 2007-2008)

Opportunity fund: funding for infrastructure associated with a Canada Research Chair. Sherman PM. Canada

role of STAT3 during H. pylori infection. Jones NL. Canadian Institutes of Health Research

International Collaboration Project. Zlotkin S.

Foundation for Innovation, Leaders ($427,348 total

($100,000 2007-2008)

Canadian Institutes of Health Research

[$170,939 direct from CFI] 2008)

($25,000 2007-2008) Outcomes in severe paediatric ulcerative colitis:

Immune regulation and biomarker development in paediatric and adult onset human autoimmune

Investigation of Helicobater pylori survival in host cells.

a multicentre study. Griffiths AM. Schering Canada

diseases. Bar-Or A, Banwell B, Piccirillo CA,

Jones NL. Early Researcher Award, Ontario Ministry

($350,000 2007-2009)

Polychronakos C, Sherman PM. Canadian Institutes of

of Research and Innovation ($150,000 2006-2011) Pico-salax versus poly-ethylene glycol for bowel

Health Research Team Grant ($2,018,445 2007-2112) Knowledge translation award. Zlotkin S. Canadian Induction of autophagy by H. pylori. Jones NL.

Institutes of Health Research ($100,000 2006-2007)

cleanout before colonoscopy in children: a single blinded randomized controlled trial. Ling SC, Griffiths AM, Turner D. Ferring Inc. ($24,000 2006-2008)

Canadian Association of Gastroenterology/ Canadian Institutes of Health Research/Abbott

Molecular genetics, SBDS function and deficiency in

($45,000 2007-2009)

SDS. Rommens JM, Durie PR. National Institutes of

Protocol AI463-08: evaluation of the

Health ($1,250,000 2004-2009)

pharmacokinetics, safety, tolerability and efficacy of entecavir (ETV) in paediatric subjects with chronic

Infliximab in paediatric ulcerative colitis: a multicentre study. Griffiths AM. Centocor (per patient

Neonatal protein and energy metabolism. Pencharz P.

hepatitis B virus (HBV) infection who are HBeAg-

remuneration; anticipated $100,000 2007-2009)

Medical Research Council/Canadian Institutes of

positive. Ling SC. Bristol-Myers Squibb

Health Research ($136,817 2006-2011)

($25,000 per patient, 2007-2013)

72 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Role of autophagy in Helicobacter pylori infection

Studies of paediatric liver transplantation (SPLIT).

The contribution of genetic modulators of disease

and disease. Jones NL. Canadian Institutes of Health

Ng V, Fecteau A. National Institutes of Health/

severity in cystic fibrosis to other diseases with

Research ($103,959 per year 2008-2013)

National Institute of Diabetes and Digestive and

similarities of clinical phenotype. Durie PR, Zielenski J.

Kidney Diseases (US$75,000 2005-2010)

Genome Canada ($5,787,662 2005-2009)

inflammatory bowel disease. Sherman PM. Crohn’s

Studies of primary sclerosing cholangitis (STOPSC).

The use of indicator amino acid oxidation to determine

and Colitis Foundation of Canada Fay Shapiro Cutler

Ling SC, Durie P, Griffiths AM. Musette and Allen

amino acid requirement. Pencharz P, Ball R. Medical

Grant-In-Aid of Research ($375,000 2007-2010)

Morgan Jr. Foundation (annual and patient-based

Research Council/Canadian Institutes of Health

stipends, $10,000 per year plus $200 per patient

Research ($152,967 2005-2010)

Role of probiotics in the management of experimental

Salary award: Tier 1 (renewal). Sherman PM.

2006-2009) Training grant: cell signalling in mucosal inflammation

Canada Research Chair ($1,400,000 2008-2015) Targeted small molecule therapies for cystic

and pain. Ellen R, Sherman PM. Canadian Institutes

SBDS protein expression in peripheral blood

fibrosis. Bear CE, Deber CM, Durie PR, Lingwood C,

for Health Research ($300,000 per year 2002-2008)

leukocytes. Durie PR, Rommens JM, Shimamura A.

Rotin D, Ratjen F, Yeger H. Canadian Cystic

Shwachman Diamond Syndrome Foundation

Fibrosis Foundation - BREATHE Program

(US$30,000 per year 2006-2008)

($480,000 per year 2004-2009)

Upper limits of leucine requirements. Pencharz P. International Council for Amino Acid Science ($155,850 2008)

Short bowel syndrome, neonatal piglet model. Turner J,

Team in childhood obesity research. McCrindle B,

Ball R, Pencharz P, Wales P. SickKids Foundation

Anderson GH, Hamilton J, Parkin P, Pencharz P.

($62,690 2008-2009)

Canadian Institutes of Health Research

placebo controlled study of VX770 in patients with

($506,842 2008; $464,474 2008-2011)

cystic fibrosis having G551D mutations to evaluate

VX06-770-101: a Phase 2a, randomized, double-blind,

Sprinkles project support. Zlotkin S. HJ Heinz

safety, phamacokinetics and biomarkers of CFTR

Company Foundation ($600,000 2006-2007)

activity. Durie PR (Toronto site). Vertex Pharmaceuticals, Inc. (US$30,000 per year 2007-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 73

Dr. Angela Punnett

DIVISION HEAD Dr. Victor Blanchette FULL-TIME Dr. Oussama Abla Dr. Sarah Alexander Dr. Ute Bartels Dr. Sylvain Baruchel

Dr. Eric Bouffet Dr. Leonardo Brandão Dr. Manuel Carcao Dr. Helen Chan Dr. John Doyle Dr. Yigal Dror Dr. Adam Gassas Dr. Ron Grant

Dr. Abha Gupta Dr. Hans Hitzler Dr. Annie Huang Dr. Meredith Irwin Dr. Walter Kahr Dr. Melanie Kirby Dr. David Malkin Dr. Ahmed Naqvi

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Paul Nathan Isaac Odame Angela Punnett Lillian Sung Uri Tabori Sheila Weitzman Suzan Williams

CROSS-APPOINTEES/ PART-TIME Dr. Anthony Chan Dr. Stephen Comay Dr. Lee Ann Gallant Dr. Mark Greenberg Dr. David Hodgson Dr. Nicole Inch

Dr. Dr. Dr. Dr. Dr.

Normand Laperriere Barbara-Ann Millar Aubrey Maze Ben Saxon Jill Solomon

Division of Haematology/Oncology OVERVIEW

program (Program Co-Heads, Drs. David Malkin and

cancer genetics, blood and marrow transplantation

The Division of Haematology/Oncology provides a

Rosanna Weksberg). The haematology section has

and paediatric thrombosis and haemostasis.

diagnostic service and specialist care for children

large programs in paediatric thrombosis and

T) presents with clinical heterogeneity and is

Paterson AD, Liu XQ, Wilson C, Lahtinen U, Anttonen

D: Developmental disregard predicts improvement

candidate founder mutation in individuals of Ashkenazi

AK, Lehesjoki AE: The novel neuronal ceroid

after constraint-induced movement therapy in

Jewish origin. Molecular Genetics and Metabolism

lipofuscinosis gene MFSD8 encodes a putative

hemiplegic children. Journal of Developmental and

2008: 93(2): pp 179-189.

lysosomal transporter. American Journal of Human

Behavioural Pediatrics 2007: 28(4): p S3.

N: Short-chain acyl-CoA dehydrogenase gene mutation

Thomas T, Banwell B: Multiple sclerosis in children.

Genetics 2007: 81(1): pp 136-146. Tagliabracci VS, Turnbull J, Wang W, Girard JM, Snead OC III, Donner EJ: A new generation of

Seminars in Neurology 2008: 28(1): pp 69-83.

Zhao X, Skurat AV, Delgado-Escueta AV, Minassian BA, Turnbull J, Kumar S, Ren Z, Shanmugakonar M,

anticonvulsants for the treatment of epilepsy in

DePaoli-Roach AA, Roach PJ: Laforin is a glycogen

children. Paediatrics and Child Health 2007: 12(9):

phosphatase, deficiency of which leads to elevated

Naranian T, Ackerley CA, Minassian BA: Lafora

pp 741-744.

phosphorylation of glycogen in vivo. Proceedings of

progressive myoclonus epilepsy: disease course

the National Academy of Science USA 2007: 104(49):

homogeneity in a genetic isolate. The Journal of

Stewart LS, Nylen KJ, Persinger MA, Cortez MA,

pp 19262-19266.

Child Neurology 2008: 23(2): pp 240-242.

Gibson KM, Snead OC III: Circadian distribution of generalized tonic-clonic seizures associated

Taylor MJ: MEG in paediatrics: preface to special

Wang CH, Finkel RS, Bertini ES, Schroth M, Simonds

with murine succinic semialdehyde dehydrogenase

issue. International Journal of Psychophysiology

A, Wong B, Aloysius A, Morrison L, Main M, Crawford

deficiency, a disorder of GABA metabolism. Epilepsy

2008: 68(2): pp 83-84.

TO, Trela A, Vajsar J: Consensus statement for standard of care in spinal muscular atrophy. Journal of Child

and Behaviour 2008: May 29 [Epub ahead of print]. Taylor MJ, Mills T, Smith ML, Pang EW: Face processing Striano P, Zara F, Turnbull J, Girard JM, Ackerley CA,

in adolescents with and without epilepsy. International

Cervasio M, DeRosa G, Del Basso-De Carro ML, Striano

Journal of Psychophysiology 2008: 68: pp 94-103.

Neurology 2007: 22(8): pp 1027-1049. Wedderburn L, Varsani H, Li C, Newton K, Amato A,

S, Minassian BA: Typical progression of myoclonic

Banwell B, Bove, Corse A, Emslie-Smith A, Harding P,

epilepsy of the lafora type: a case report. National

Hoogendijk J, Lundberg I, Marie S, Minetti C,

Clinical Practice. Neurology 2007: 4(2): 106-111.

Nennesmo I, Rushing E, Sewry C, Allen E, Charman S, Pilkington C, Holton J (the International Consensus Group on JDM Biopsy), and on behalf of the UK

128 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Juvenile Dermatomyositis Research Group:

Wise JC, Sevcik RA, Morris RD, Lovett MW, Wolf M:

International consensus on a proposed score system

The relationship among receptive and expressive

infectious, toxic and metabolic headaches. In: Wolff’s

for muscle biopsy evaluation in patients with JDM,

vocabulary, listening comprehension, pre-reading

Headache and Other Head Pains (Silberstein, Dodick

for potential use in clinical trials. Arthritis Care

skills, word identification skills, and reading

and Lipton, eds.). Oxford University Press, 2007.

and Research 2007: 57(7): pp 1192-1201.

comprehension by children with reading disabilities.

Wells GD, Noseworthy MD, Hamilton J, Tein I:

Bigal ME, Gladstone JP: Headaches attributed to

Journal of Speech, Language, and Hearing Research

Chu B, Pang EW, Ochi A, Sharma R, Hunjan A, Holowka

2007: 50(4): pp 1-17.

S, Rutka J, Weiss S, Chuang S, Snead OC III, Otsubo

Yamazaki M, Ochi A, Akiyama T, Otsubo H: Epileptic

confirm the accuracy of MEG SEF locations. In: New

H: Extra-operative somatosensory evoked potentials

Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome. Canadian Journal of Neurological Sciences 2008: 35(1): pp 31-40.

high frequency oscillations. Epilepsy 2008: 2:

Frontiers in Biomagnetism (Cheyne D, Ross B, Stroink

pp 53-60. (Japanese)

G, Weinberg H, eds.). Elsevier, Amsterdam, 2007.

Westmacott R, McAndrews MP, Silver F: Altered effective connectivity within language

Yoon G, Westmacott R, MacMillan L, Quercia N,

Hahn C, Banwell B: Diseases of the peripheral

networks following left hemisphere stroke.

Koutsou P, Georghiou A, Christodoulou K, Banwell B:

nervous system. In: Pediatric Critical Care Medicine:

Brain and Cognition 2007: 63: p 1999.

Complete deletion of the aprataxin gene: ataxia with

Basic Science and Clinical Evidence (Wheeler DS,

oculomotor apraxia type 1 with severe phenotype and

Wong HR, Stanley TP, eds.). Springer-Verlag,

Westmacott R, McAndrews MP, Silver FL:

cognitive deficit. Journal of Neurology, Neurosurgery,

London, England, 2007.

Understanding medial temporal activation in memory

and Psychiatry 2008: 79: pp 234-236. Jones-Gotman M, Smith ML, Wieser HG: Intra-arterial

tasks: evidence from fMRI of encoding and recognition in a case of transient global amnesia. Hippocampus

Zhang Y, Minassian BA: Will my Rett Syndrome patient

amobarbital procedures. In: Epilepsy: A Comprehensive

2008: 18: 317-325.

walk, talk and use her hands? Neurology 2008:

Textbook, 2nd Edition (Engel J, Pedley T, eds.).

70(16): pp 1302-1303.

Lippincott Williams & Wilkins, New York, 2008.

BOOKS AND BOOK CHAPTERS

Kerr M, Smith ML: Learning disorders. In: Epilepsy: A

Widjaja E, Blaser S, Miller E, Kassner A, Shannon P, Chuang SH, Snead OC III, Raybaud CR: Evaluation of subcortical white matter and deep white matter tracts

Bayle DJ, Bostan AC, Taylor MJ: Attention to the

Comprehensive Textbook, 2nd Edition (Engel J, Pedley

in malformations of cortical development. Epilepsia

person or the emotion: underlying brain activations in

T, eds.). Lippincott Williams & Wilkins, New York, 2008.

2007: 48: pp 1460-1469.

MEG. In: New Frontiers in Biomagnetism (Cheyne D, Ross B, Stroink G, Weinberg H, eds.). Elsevier, Amsterdam, 2007.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 129

Martín del Campo C, Pérez Velázquez JL, Cortez MA:

Sharma R, Pang EW, Mohamed I, Chu B, Hunjan A,

FUNDING

EEG recording in rodents. In: Current Protocols in

Ochi A, Holowka S, Gaetz W, Chuang S, Snead OC,

An investigation of the neural mechanisms underlying

Neuroscience (Gerfen C, Rowgawski MA, eds.).

Otsubo H: Magnetoencephalography in children:

amblyopia. Wong A, Taylor MJ, Cheyne DO. Canadian

John Wiley & Sons Inc., New Jersey, 2008.

routine clinical protocol for intractable epilepsy

Foundation for Innovation Leadership Fund

at The Hospital for Sick Children. In: New Frontiers

($1,015,761 2007-2011)

Otsubo H, Imai K: Clinical neurophysiology of cortical

in Biomagnetism (Cheyne D, Ross B, Stroink G,

malformations: magnetoencephalography and

Weinberg H, eds.). Elsevier, Amsterdam, 2007.

electroencephalography. In: Malformations of the

Atypical absence epilepsy: GABA B receptor-mediated mechanisms. Snead OC III, Francis J, Cortez MA.

Nervous System, Handbook of Clinical Neurology (Sarnet

Stefan H, Olofsson OE, Snead OC III: Typical and

Canadian Institutes of Health Research ($315,376

HB, Curatolo P, eds.). Elsevier Ltd., Edinburgh, 2007.

atypical absence seizures, myoclonic absences, and

2000-2008)

eyelid myoclonias. In: Epilepsy: A Comprehensive Pang EW, Otsubo H, Sharma R, Hunjan A, Chu B,

Textbook, 2nd Edition (Engel J, Pedley T, eds.).

Autism Treatment Network: Co-operative multicentre

Snead OC III: Unilateral abnormalities on MEG

Lippincott Williams & Wilkins, New York, 2008.

program for research and treatment of autism.

Syndrome. In: New Frontiers in Biomagnetism (Cheyne

Tein I: Primary carnitine transporter defect. In: Neurobase,

Goldfarb C, Berall G, Bradley E, Brian J, Freeman N,

auditory evoked fields in children with Landau-Kleffner

Roberts W, Loh A , Feigenbaum A, Weiss S, Marcon M,

D, Ross B, Stroink G, Weinberg H, eds.). Elsevier,

14th Edition (Gilman N, Goldstein GW, Waxman SG, eds.).

Atkinson A, Taylor MJ, Stinson J, Mitchell S, Green P.

Amsterdam, 2007.

Arbor Publishing Corp., La Jolla, CA, 2008.

Autism Speaks ($1,000,000 2008-2012)

Perez Velazquez JL, Garcia Dominguez L, Wennberg R:

Thomas P, Snead OC III: Absence status epilepticus.

Carnitine-responsive cardiomyopathy and the different-

The fluctuating brain: dynamics of neuronal activity. In:

In: Epilepsy: A Comprehensive Textbook, 2nd Edition

affinity carnitine transporters. Tein I. Heart and Stroke

Nonlinear Phenomena Research Perspectives (Wang

(Engel J, Pedley T, eds.). Lippincott Williams & Wilkins,

Foundation of Ontario ($267,144 2004-2007)

CW, ed.). Nova Science Publishers, Inc.,

New York, 2008.

New York, 2007.

Centre for the Investigation of Neuroplasticity and Weiss SK: Sleep disorders. In: Adolescent Healthcare:

Developmental Disorders. Snead OC III, Taylor MJ,

RamachandranNair R, Weiss SK, MacGregor D: Sleep

A Practical Guide, 5th Edition (Katzman D, ed.).

Salter M, Josselyn S, Westall C, Dennis M, Tannock R,

and metabolism. In: Head Injury in Children and

Lippincott, Williams & Wilkins, Philadelphia, PA, 2008.

Sled J, Cheyne D, Campbell M. Canadian Foundation

Adolescents (MacGregor D, Kulkarni A, Dirks P, Rumney P, eds.). MacKeith Press, London, 2007.

130 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

for Innovation ($15,709,086 2006-2011)

Centre for the Study of Complex Childhood Diseases.

Genetics of reading disabilities. Barr CL, Kerr E,

Investigation of an epilepsy epidemic in Cameroon.

Post M (Tein I, CFI Team). Canada Foundation

Lovett MW. Canadian Institutes for Health Research

Snead OC III, Weiss SK, Elliott I, Smith ML,

for Innovation (CFI) ($21,000,000 2007-2012)

($1,125,785 2008-2013)

Stephen D, Keystone J, Cockburn L, Tsang V,

Characterization of factors and mechanisms that

Globus pallidus deep brain stimulation in children with

Children’s Hospital Foundation Chair in

explain the association between physical activity and

dystonia. Soman T, Moro E, Lozano AM, Hodaie M,

Paediatric Neuroscience ($20,000 2007-2008)

lung health in cystic fibrosis: does muscle function

Westmacott R, Gorman D. SickKids Foundation New

play a role? Ratjen F, Coates A, Tein I. Canadian

Investigator’s Grant ($118,617 2008-2010)

Fongwa M, Takougang I, Akeneck J. Bloorview

Krembil Neuroscience Centre Seeding Grant. Andrade D. Krembil Neuroscience Centre ($39,000 2007-2008)

Cystic Fibrosis Foundation Grant ($158,000 2006-2008)

Health-related quality of life in children with epilepsy: the first two years after diagnosis through parents’

Making a better brain: an Ontario neuroimaging

CIHR Team in Childhood Obesity Research. McCrindle

eyes. Smith ML, Nixon-Speechley K, Camfield C,

consortium. Menon RS, Bartha R, Chronik BA,

B, Anderson H, Hamilton J, Parkin P, Pencharz P

Wiebe S, Zou G, Levin S. Canadian Institutes of

Henkelman M, Kassner A, Lee TY, Mikulis D, Moller HJ,

(Tein I, co-applicant). Canadian Institutes of Health

Health Research ($393,692 2003-2008)

Rutt BK, Sled JG, Taylor MJ. Ontario Research Foundation ($4,161,595 2008-2011)

Research ($2,452,522 2008-2013) Identification of genetic causes of paediatric Cognitive behavioural therapy as a novel approach to

neurological conditions and using these to uncover the

MEB diseases. Vajsar J. SickKids Foundation

the management of dystonia in children: a pilot study.

cellular pathways involved and to determine the ways

($37,000 2006-2007)

Soman T, Logan W, Chen R, O’Driscoll H. SickKids

in which they are disturbed. Minassian BA. Canada

Foundation ($4,500 2007-2008)

Research Chairs Program ($478,585 2006-2011)

Molecular basis of Lafora bodies (starch formation in the brain) and Lofora’s progressive myoclonus epilepsy. Minassian BA, Ackerley CA, Scherer SW,

CREMS – Comprehensive Research Experience for

Immune regulation and biomarker development for

Medical Students. Weiss SK, Zak M, Mulligan J. The

paediatric and adult autoimmune diseases. Bar-Or A,

Lohi H. Canadian Institutes of Health Research

Hospital for Sick Children, Division of Neurology;

Banwell B, Piccirillo P, Sherman P, Polychronakos C.

($1,146,830 2006-2011)

CREMS-University of Toronto ($5,000 2008)

Canadian Institutes of Health Research New Emerging Team Grants ($2,018,445 2007-2012)

Curing adult polyglucosan body disease by eliminating

Multimodal neuroimaging of frontal lobe cognitive function in children. Taylor MJ, Donner, EJ, Pang EW.

the polyglucosan bodies. Minassian BA. Adult

Canadian Institutes of Health Research ($466,335

Polyglucosan Body Disease Research Foundation

2006-2011)

($59,000 2007-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 131

Multimodal neuroimaging and neurobehavioural

Neuroimaging measures of brain function in preterm

Prospective study of the clinical epidemiology,

outcomes in preterm neonates. Taylor MK, Whyte H,

neonates. Taylor MJ, Sled JG, McNamara P, Whyte

pathology, and neuroimaging features of Canadian

Shroff M, Donner E, Moore A, Soman T. Canadian

HEA, Moore AM, Donner EJ, Shroff MM. Collaborative

children with clinically isolated demyelinating

Institutes of Health Research ($925,000 2007-2012)

Health Research Program ($361,860 2008-2011)

syndromes. Banwell B, Bar-Or A, Sadovnick D, Arnold

Multiple-component remediation for struggling

Neuroimaging measures of brain function in preterm

($4,300,000 2004-2009)

D. Multiple Sclerosis Scientific Research Foundation middle school readers. Morris R, Lovett MW,

neonates. Taylor M, Donner EJ, McNamara PJ,

Sevcik R, Frijters JC. Institute of Education Sciences

Moore AM, Shroff MM, Sled JG, Whyte HEA: Natural

Randomized controlled trial to improve sleep in children

($2,882,630 US 2006-2010)

Sciences and Engineering Research Council

who have both epilepsy and neurodevelopmental

of Canada ($361,860 2008-2011)

disabilities. Weiss SK. The Hospital for Sick Children National Grants Program ($121,328 2007-2009)

Multi-site paediatric network for fMRI mapping in childhood epilepsy. Smith ML, Gaillard WD.

Neuroprotection by inhibitors of apoptosis proteins

American Epilepsy Society ($60,000 2005-2007)

following neonatal stroke. Askalan R. Clinician-

Role of the carnitine/organic cation transporters in

Scientist Award (Phase I), Heart and Stroke

the mammary gland and implications for the suckling

Foundation of Ontario ($50,000 2007-2010)

infant. Tein I. Mead-Johnson Grant ($28,500 2007-2008)

Murine knockout model of 4-hydroxybutyric aciduria. Snead OC III, Gibson KM. National Institute of

Non-invasive decompression of the superior sagittal

Shared epitopes of functional variants of the organic

sinus to prevent perinatal brain injury in neonatal

cation/carnitine transporter family (OCTN1 and OCTN2)

Murine treadmill (6-lane) with electric shocker. Tein I.

cerebral sinovenous thrombosis. deVeber G, Kirton A,

and campylobacter jejuni may underlie susceptibility to

SickKids Foundation Equipment Grant ($6,500 2008)

Tan M, Shroff M, Moore A. Ontario Federation for

Crohn’s disease and Guillain-Barre syndrome. Tein I.

Cerebral Palsy ($12,875 2007-2008)

SickKids Foundation ($5,000 2007-2008)

with autism. Taylor M, Donner EJ, Roberts SW,

Predicting neurobehavioural outcome in preterm

Spatio-temporal patterns of synchronized brain activity

Bayless S, Shroff M. National Alliance for Autism

neonates. Taylor M.J, Whyte HE, Raybaud C, Moore

Perez Velazquez JL. National Science and Engineering

Research ($155,907 2006-2008)

AM, Donner EJ, Shroff MM, Frisk VA. Canadian

Research Council of Canada Discovery Grant

Institutes of Health Research ($929,129 2007-2012)

($172,165 2007-2011)

Health ($587,500 USD 2006-2011)

Neuroimaging and frontal lobe function in children

132 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

The Children’s Stroke Project. deVeber G. Anonymous

TIPS (Tips for Infant and Parent Sleep). Stremler R,

Validation of accelerometry as a measure of physical

Children’s Foundation ($2,070,000 2001-2009)

Weiss SK, Hodnett E, Lee K, MacFarlane J, Willan A.

activity and inactivity in children with chronic disease.

Canadian Institutes of Health Research ($274,846

Feldman B, Stephens S, Takken T, Van der Net J,

2007-2009)

Tremblay M, Eslinger D, Bigger W, Wright V,

The practice of paediatric movement disorders amongst

Schneiderman-Walker J, Longmuir P, Banwell B,

paediatricians. Soman TB, Lamba D, Logan WJ,

Beyenne J. Canadian Institutes of Health Research,

Lang AE. SickKids Foundation ($500 2006-2008)

Towards the correction of Rett-like behaviour in MeCP2-deficient mice by exogenous gene delivery.

Institute of Musculoskeletal Health and Arthritis -

The role of muscle carnitine deficiency and the

Snead OC III. Canadian Institutes of Health Research

Seed Grant: Physical Activity, Sport and Health

carnitine/organic cation transporter family in

($117,137 2004-2009)

Competition ($64,985 2007-2008)

Duchenne muscular dystrophy. Tein I. SickKids Traumatic brain injury in children and youth: the

Validation of the NIH stroke scale in children. deVeber

complexities of co-morbidities. Perez Velazquez JL,

G, Ichord R. National Institute of Neurological

The role of vigabatrin in the treatment of infantile

Hutchison J, Schachar R. Ontario Neurotrauma

Disorders and Stroke ($45,000 2006-2009)

spasms. Carmant L, Weiss, SK. Canadian Institutes

Foundation ($250,000 2007-2010)

Foundation ($7,650 2007-2008)

Variability of brain coordination dynamics as a

of Health Research ($860,000 2003-2009) Unravelling the pathogenesis of the autophagic

prognostic tool in traumatic brain injury. Perez

The Ts65Dn mice model. Cortez MA. SickKids

vacuolar myopathies. Minassian BA, Ackerley C,

Velazquez JL. SickKids Foundation ($48,500

Foundation ($10,000 2005-2008)

Manolson MF. Canadian Institutes of Health

2007-2008)

Research ($779,395 2007-2012)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 133

Division of Dr. Angelo Mikrogianakis

DIVISION HEAD Dr. William Mounstephen FULL-TIME Dr. Kathy Boutis Dr. Kevin Chan Dr. Seen Chung

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Yaron Finkelstein Stephen Freedman Shauna Jain Anna Jarvis Kelly Keogh Luba Komar Amina Lalani

Dr. Sanjay Mehta Dr. Angelo Mikrogianakis Dr. Bruce Minnes Dr. Trent Mizzi Dr. Jonathan Pirie Dr. Savithiri Ratnapalan Dr. Susan Schneeweiss

Dr. Suzanne Schuh Dr. Dennis Scolnik Dr. Jennifer Thull-Freedman

PART-TIME Dr. Sherry Baine Dr. Susanna Benseler

Dr. Carolyn Calpin Dr. Joseph Copeland Dr. Anh Do Dr. Janine Flanagan Dr. John Freedman Dr. Claudio Fregonas Dr. Sabine George

Dr. Cara Gilman Dr. Peter Glazer Dr. Donna Goldenberg Dr. Massoud Grouhi Dr. Shuja Hafiz Dr. Mark Handley-Derry Dr. Leah Harrington

Division of Paediatric Emergency Medicine OVERVIEW

paediatric emergency medicine knowledge and skills.

HONOURS AND AWARDS

The Emergency Department (ED) at The Hospital for

We have also worked with the Canadian Armed Forces

Chan K: Division of Paediatric Emergency Medicine,

Sick Children provides acute care to children who are ill

to provide paediatric training to their physician

The Hospital for Sick Children Research Recognition

or who have been injured. We are both the primary care

assistants. We provide telephone consultative support

Award in recognition of excellence in outstanding

centre for children in Toronto, plus the tertiary referral

to the Canadian Armed Forces in Afghanistan for any

effort and contribution to research, 2007-2008.

centre for the Greater Toronto Area (GTA), in addition to

paediatric concerns they may encounter. The division

being the designated Paediatric Trauma Centre for the

continues to run Paediatric Life Support Courses (PALS

Chan K: Fellow, Munk Centre for International Studies,

GTA. The division has 21 full-time staff, the majority of

and APLS). We also have a well-developed weekly

University of Toronto, 2007.

whom are recertified in both paediatrics and paediatric

half-day of educational activities for trainees and all

emergency medicine, plus a cadre of part-time

health care providers in the Emergency Department.

Dr. Leah Harrington: RHA Haslam, Pre-clerkship

paediatricians. Over the next two to three years we will

In the fall, the division will present the fifth annual

Teaching Award, Department of Paediatrics, The

be redeveloping the Emergency Department’s physical

Paediatric Emergency Medicine Update which in the

Hospital for Sick Children, University of Toronto, 2008

plant. This redevelopment will ensure that the ED at

past four years has been an overwhelming success.

SickKids remains a leader in paediatric emergency care. In addition, we have recently introduced an electronic

Mehta S: RHA Haslam Pre-clerkship Teaching Award for Research in the division remains clinically focused,

Excellence in Pre-clerkship Teaching (Runner-up), 2008.

tracking system that replaces the old white board.

covering a wide range of topics from respiratory

These changes will allow us to provide more efficient

disease acute care management, orthopaedic injuries,

Mikrogianakis A: The Hospital for Sick Children,

and effective care to our patients.

pain and sedation, to drug errors. Research done

Department of Paediatrics, the Richard Rowe Award

within the division continues to be presented

for Clinical Excellence in Paediatric Medical Care

The division has an active three-year academic

nationally and internationally with publications in

(Junior Award), 2008.

fellowship program. The Royal College of Physicians

peer-reviewed journals. Overall, a substantial increase

and Surgeons has fully accredited our fellowship

in clinical research activities has resulted, putting

Mikrogianakis A: Clinical Recognition Award. In

program. In addition, we have a number of clinical

us on par with the other North American leaders in

recognition of outstanding effort and contribution

departmental fellows from around the world spending

paediatric emergency medicine.

to the Emergency Department, Division of Paediatric

a year or more with us further developing their

Emergency Medicine Awards Day, 2008. Mikrogianakis A: Postgraduate PERLS Teaching Award (Runner-up), 2008.

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Nicole Inch Edward Jin Eddy Lau Yen Le Patricia Linders Steven Moss Patricia Neelands

Dr. Carole O’Beirne Dr. Linda Pedder Dr. Christina Ricks Dr. Jennifer Riley Dr. Lillian Rojnica Dr. Domenick Shelton Dr. Heshy Sturm

Dr. Dr. Dr. Dr. Dr.

Rahim Valani Charmaine Van Schaik Jeff Weisbrot Sheldon Wise Hirotaka Yamashiro

CROSS-APPOINTEES Dr. Eyal Cohen Dr. Astrid Guttmann Dr. Ronik Kanani Dr. Christoph Licht Dr. Jonathan Tolkin Dr. Hilary Whyte Dr. Jamie Hutchison

CLINICAL FELLOWS Dr. Amir Ahmad Dr. Samim Al-Qadhi Dr. Miguel Glatstein Dr. Alexandra Hernandez Dr. Maria Oliva Dr. Charles Stewart Dr. Klaus Werner

ACADEMIC FELLOWS Dr. Abdullah Al-Dhafian Dr. Nesrin Alharthy Dr. Ahmed Al-Saleh Dr. Alawi Baaboud Dr. Vered Gazit Dr. April Kam

The Hospital for Sick Children 2007-08 ANNUAL REPORT 135

Mikrogianakis A: Lionel Weinstein Clerkship Teaching

PUBLICATIONS

Dubnov-Raz G, Fogelman R, Juurlink D. N, Merlob P,

Award for Excellence in Teaching, Department of

Al-Ansari K, Sulowski C, Ratnapalan S: Analgesia and

Ito S, Koren G, Finkelstein Y: Prolonged QT interval in

Paediatrics, The Hospital for Sick Children, University

sedation practices for incarcerated inguinal hernias

neonates exposed to selective serotonin reuptake

of Toronto (Runner-up), 2008.

in children. Clinical Pediatrics (Philadelphia) 2008:

inhibitors in late pregnancy. Clinical Pharmacology

May 19 [Epub ahead of print].

and Therapeutics 2008: 83: p S42.

Pirie J: Award for Excellence in Postgraduate Medical Education in Teaching Performance/Mentorship/

Avner M, Finkelstein Y, Hackam D, Koren G:

Finkelstein Y, Schechter T, Garcia F, Nurmohamed L,

Advocacy, University of Toronto, 2008.

Establishing causality in pediatric adverse drug

Juurlink D, Blanchette V, Koren G: Is morphine

reactions: use of the Naranjo Probability Scale.

exposure associated with acute chest syndrome in

Pirie J: Continuing Education Award. For excellence

Pediatric Drugs 2007: 9: pp 267-270.

Paediatrics, The Hospital for Sick Children, 2008.

children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study. Clinical

in long-term contribution to CE in the Department of Boutis K, Willison D: To pay or not to pay: is that the

Therapeutics 2007: 29: pp 2738-2743.

right question? Student BMJ 2008: 16: pp 118-119. Finkelstein Y, Garcia-Bournissen F, Schechter T,

Pirie J: Clinical Teaching Award, Division of Paediatric

Nurmohamed L, Koren G: Is morphine administration

Emergency Medicine, The Hospital for Sick Children

Brandao L, Harrington D. J, Finkelstein Y, Cohen E,

(Runner-up), 2008.

Thompson M, Verjee Z: Superwarfarin exposure and

to children with sickle cell disease: and vaso-occlusive

severe coagulopathy in two infants: novel biomarkers

crisis associated with an increased risk for the

Schuh S: Article selected as one of the Best Articles

for diagnosis and prolonged therapy. Clinical

development of acute chest syndrome: a case-

Relevant to Pediatric Immunology by the American

Toxicology 2007: 45: pp 637.

fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Scolnik D: Global Health Scholar, Peter A. Silverman

Chan KJ: A clinical trial gone awry: the Chocolate Happiness Undergoing More Pleasantness (CHUMP)

Finkelstein Y, Nava-Ocampo AA, St. Pierre E,

study. Canadian Medical Association Journal 2007:

Schechter T, Walker S, Koren G: Population

177: pp 4-5.

pharmacokinetics of doxorubicin in infants and children with malignant diseases. Clinical

Centre for International Health, Mount Sinai Hospital, University of Toronto, 2007.

Dubnov G, Finkelstein Y, Koren G: Recommend n-3 fatty acids in pregnancy? Canadian Family Physician 2007: 53: pp 1299-1300.

Dr. Dr. Dr. Dr.

Melissa Parker Tania Principi Ayelet Rimon-Babad Hayat Saddeq

ADMINISTRATIVE STAFF Majda Savaglio Andrew Serrano Sabrina Dubeau Nicole Winters Maggie Stevanovic

cross-over study. Clinical Pharmacology and Therapeutics 2007: 81: pp S78-S79.

Academy of Pediatrics. Title: High-dose inhaled

Deborah Atchison Joanna Barnes Dana Doll Ritsa Iriotakis Patricia Nedanovski

Pauline Smith Viki Dukic Traci Peggie Sandra Miller

Pharmacology and Therapeutics 2007: 81: p S78.

Finkelstein Y, Fogelman R, Juurlink D. N, Merlob P, Ito S,

Goldman RD, Mounstephen W, Langer J: Prospective

Mikrogianakis A, Osmond MH, Nuth JE, Shephard A,

Koren G, Dubnov-Raz G: Antenatal exposure to selective

validation of pediatric appendicitis score. Journal of

Gaboury I, Jabbour M: Evaluation of a multidisciplinary

serotonin reuptake inhibitors prolongs the QT Interval in

Pediatrics 2008: March 19 [Epub ahead of print].

pediatric mock trauma code educational initiative: a pilot study. Journal of Trauma 2008: 64(3): 761-767.

Neonates. Clinical Toxicology 2007: 45: p 624. Goldman RD, Narula N, Klein-Kremer A, Finkelstein Y, Freedman SB, Adler M, Seshadri R, Powell EC:

Rogovik AL: Predictors for opioid analgesia

Osmond MH, Gazarian M, Henry RL, Clifford T, Tetzlaff

Antiemetics for acute gastroenteritis: a never ending

administration in children with abdominal pain

J, Mikrogianakis A, and the PERC Spacer Study Group:

story. Journal of Pediatric Gastroenterology and

presenting to the emergency department. Clinical

Barriers to metered-dose inhaler/spacer use in

Nutrition 2007: 45: pp 132-133.

Journal of Pain 2008: 24(1): pp 11-15.

Canadian pediatric emergency departments. Academic

Freedman SB: Acute infectious pediatric gastroenteritis:

Goldman RD, Scolnik D, Chauvin-Kimoff L, Farion KJ, Ali

beyond oral rehydration therapy. Expert Opinion on

S, Lynch T, Gouin SM, Osmond M, Johnson DW, Klassen

Pirie J: Pre- and post-paediatric emergency care:

Pharmacotherapy 2007: 8: pp 1651-1665.

TP: Practice variation among paediatric emergency

where do we go from here? Paediatrics and Child

physicians in the management of febrile neonates.

Health 2007: 12: p 451.

Emergency Medicine 2007: 14(11): pp1106-1113.

Freedman SB, Thakkar VA: Easing the strain on a

Paediatric Child Health 2007: 12 Suppl: p 61A. Ratnapalan S: Cutting the vagus nerve: clinical

pediatric tertiary care center: the use of a redistribution system. Archives of Pediatrics and

Harrington DJ, Dominic J, Brandao LR, Leonardo R,

practice and research in medicine. Canadian Family

Adolescent Medicine 2007: 161(9): pp 870-876.

Cohen E, Finkelstein Y, Thompson M, Verjee Z:

Physician. 2008: 54(5): p 748.

Superwarfarin exposure and severe coagulopathy in Freedman SB, Haladyn JK, Floh A, Kirsh J, Taylor G,

two infant immigrants: unequivocal diagnosis using

Ricks C, Ratnapalan S, Jain S, Tait G: Evaluating

Thull-Freedman J: Pediatric myocarditis: emergency

novel biomarkers. Therapeutic Drug Monitoring 2007:

computer-assisted learning for common pediatric

department clinical findings and diagnostic evaluation.

29: p 466.

emergency procedures. Pediatric Emergency Care 2008: 24(5): pp 284-286.

Pediatrics 2007: 120(6): pp 1278-1285. Mehta SV: Neuroimaging for pediatric minor closed Freedman SB, Thull-Freedman J: Pediatric dehydration

head injuries. Paediatrics and Child Health 2007:

assessment and oral rehydration therapy. Pediatric

12(6): pp 482-484.

Emergency Medicine Reports 2008: 13(2): pp13-28.

Schechter T, Finkelstein Y, Williams S, Chan A K, Ali M, Brandao LR, Leonardo R: Dosing and safety of unfractionated heparin in infants with thrombotic complications. Pediatric Blood and Cancer 2007: 48: pp 642-643.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 137

Schecheter T, Afzal S, Finkelstein Y, Doyle J, Dupuis L:

BOOKS AND BOOK CHAPTERS

Finkelstein Y: Poisoning in pregnancy. In: Medication

Daclizumab therapy for pediatric steroid-resistant

Chan K: Economics and global health. In: Understanding

Safety in Pregnancy and Breastfeeding (Koren G, ed.).

graft-versus-host disease. Paediatric Transplantation

Global Health (William Markle, Melanie Fisher, Ray

McGraw Hill Publication, New York, 2007.

2008: May 11 [Epub ahead of print].

Smego, eds.). McGraw Hill Press, New York, 2007.

Scolnik D, Lovinsky R, Aronson L, Toledano K, Glazier

Chan K, Rosenberg M, Stewart CC, Hall T: Hurdles and

Mehta SV: Smoke inhalation. In: The Hospital for Sick Children Manual of Pediatric Trauma (Cheng A,

R, Eisenstadt J, Eisenberg P, Wilcox L, Rowsell R,

opportunities in global health program. In: Developing

Mikrogianakis A, Valani R, eds.). Lippincott, Williams

Silverman M: Efficacy of a targeted, oral penicillin-

Residency Training in Global Health: A Guidebook

& Williams, Toronto, 2007.

based yaws control program among children living in

(Evert J, Stewart C, Chan K, Rosenberg M, Hall T,

rural South America. Clinical Infectious Disease 2003:

eds.). Global Health Education Consortium, San

Pirie J, Hutchison C: Pediatric procedures. In: The

36(10): pp 1232-1238.

Francisco, 2008.

Hospital for Sick Children Handbook of Pediatrics, 11th Edition (Dipchand A, Friedman J, eds.). Elsevier Canada, Toronto, 2008.

Tallett S, Lingard L, Hellmann J, Hilliard R, Hurley J,

Chan K, Stewart CC, Hall T: Resources for teaching in

Leslie K, Jefferies A, Mian M, Pirie J, Rosenfield J,

global health. In: Developing Residency Training in

Schneider R, Spero L: Measuring educational

Global Health: A Guidebook (Evert J, Stewart C, Chan

Scolnik D: Health as a bridge to peace: CISEPO

workload: a pilot study of paper-based and PDA tools.

K, Rosenberg M, Hall T, eds.). Global Health

as a case study. VDM Verlag Dr. Muller, Saarbrucken,

Medical Teacher 2008: 30: pp 296-301.

Education Consortium, San Francisco, 2008.

Germany, 2007. Stewart CC, Dillibaugh L, Chan K: Examples of global

Warren DW, Jarvis DA, LeBlanc L, Gravel J, and

Creery D, Mikrogianakis A: Sudden infant death

the CTAS National Working Group (NWG): Revisions

syndrome, BMJ Clinical Evidence Handbook, BMJ

health curricular components. In: Developing

to the Canadian Triage and Acuity Scale Paediatric

Publishing Group Ltd., London, UK, 2007.

Residency Training in Global Health: A Guidebook

Evert J, Stewart C, Chan K, Rosenberg M, Hall T:

eds.). Global Health Education Consortium, San

Developing Residency Training in Global Health:

Francisco, 2008.

(Evert J, Stewart C, Chan K, Rosenberg M, Hall T,

Guidelines (PaedCTAS) ED administration. Canadian Journal of Emergency Medicine 2008: 10(3): p 224.

A Guidebook. Global Health Education Consortium, San Francisco, 2008.

138 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

FUNDING

Children with fractures suspicious for abuse. Why are

Predictors for diagnostically accurate ultrasound

A randomized controlled trial of casting versus wrist

they missed in the emergency department? Boutis K,

in children with suspected appendicitis. Doria A,

splint in children with minimally angulated distal radius

Alharty N, Cory E, Au H, Ravichandiran N. Canadian

Schuh S, Cheng A, Langer J, Tomlinson G.

fractures in children. Boutis K, Howard A, Babyn P,

Hospitals Injury Reporting and Prevention Program

SickKids Foundation ($128,000 2007-2009)

Willan A. SickKids Foundation ($129,775 2006-2008)

($4,000 2006-2007) Palatability of oral rehydration solutions (PORS).

Barriers on the use of paediatric ankle X-ray decision

Global health education consortium global health

Freedman SB, Boutis K, Schuh S. Paediatric

rules. Boutis K, Constantine E, Narayanan U. The

modules. Hall H, Chan K, Neusy A-J, Jones E.

Consultants Partnership’s Grant ($8,210 2007-2009)

Hospital for Sick Children Paediatric Consultants

Margaret Kendrick Blodgett Foundation

Partnership’s Grant ($6,650 2007-2008)

($275,000 2006-2008)

Emergency department rapid intravenous rehydration

Funding for the position of a research co-ordinator

Roifman C, Richardson S, Schuh S. The Hospital for

(RIVR) for paediatric gastroenteritis: a randomized

in the emergency department. Schuh S. Trudell

Sick Children Research Institute ($33,800 2007-2008)

controlled trial. Freedman S, Parkin P, Willan A,

Medical ($50,000 2006-2008)

Severe influenza in children: genetic determinants and related epidemiology. Tran D, Paterson A, Beyene J,

Severe influenza in children: genetic determinants and

Schuh S. Physicians’ Services Incorporated Foundation ($165,000 2006-2008) Evaluate run exercises trained versus non-trained to

related epidemiology. Tran, D, Paterson A, Beyene J,

Impact of oximetry on hospitalization in acute bronchiolitis. Schuh S, Freedman SB, Coates A,

Roifman C, Richardson S, Schuh S. University

Parkin P, Allen U, Willan A, Ungar W, Da Silva Z.

of Toronto Dean’s Fund ($10,000 2007-2008)

evaluate the impact of the curriculum on performance.

Physicians’ Services Incorporated Foundation

Komar L. National CBRNE ($2.8 million 2008-2010)

($163,000 2007-2009)

The MAST project: magnesium for sickle cell trial. Goldman RD, Kirby-Allen M, Mounstephen W,

Exploring novel methods to improve our diagnostic

Impact of oximetry on hospitalization in acute

Friedman J. Physician’s Services Incorporated

accuracy of childhood bacterial pneumonia. Lynch T,

bronchiolitis. Schuh S, Freedman SB, Coates A,

Foundation ($157,000 2006-2008)

Klassen T, Boutis K, Johnson. Canadian Institutes

Parkin P, Allen U, Willan A, Ungar W, Da Silva Z.

of Health Research ($75,000 2006-2009)

Thrasher Research Fund ($125,000 2007-2010)

Young infants with acute recurrent wheezing: to puff or not to puff? A randomized controlled trial. Grassemann

Isotonic versus hypotonic IV maintenance fluids

H, Schuh S, Willan A, Dick P, Coates A, Ungar W.

in children: a randomized controlled trial. Geary D,

SickKids Foundation ($169,500 2008-2010)

Freedman SB, Beck C, Freidman JN. Paediatric Consultants Partnership’s Grant ($9,956 2007-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 139

Division of

Dr. Zia Bismilla

DIVISION HEAD Dr. Jeremy Friedman FULL-TIME Dr. Hosanna Au Dr. Carolyn Beck Dr. Stacey Bernstein

Dr. Catherine Birken Dr. Zia Bismilla Dr. Trey Coffey Dr. Eyal Cohen Dr. Emma Cory Dr. Astrid Guttmann Dr. Robert Hilliard Dr. Sanjay Mahant

Dr. Charlotte Moore Dr. Patricia Parkin Dr. Elena Pope Dr. Adam Rapoport Dr. Michelle Shouldice Dr. Susan Tallett Dr. Michael Weinstein

MAJOR PART-TIME Dr. Mark Feldman Dr. Saul Greenberg Dr. Moshe Ipp Dr. Sheila Jacobson Dr. Michael Peer Dr. Miriam Weinstein

PART-TIME Dr. Tony Barozzino Dr. Salvatore Cammisuli Dr. Nhung Ho Dr. Alex Levin Dr. Michael Sgro Dr. Christine Webster

ASSOCIATE Dr. Nirit Bernhard Dr. Mariana Boragina Dr. Ronik Kanani Dr. Sanjeev Luthra Dr. Ivor Margolis Dr. Sharon Naymark

Division of Paediatric Medicine OVERVIEW

The divisional complex care program continues to

section. Dr. Jeremy Friedman is an associate editor

Faculty in the the Division of Paediatric Medicine had a

develop under the leadership of Dr. Eyal Cohen, whose

of the Paediatrics and Child Health Journal. The two

successful and productive year in 2007-08. In 2008,

efforts were recognized by his selection to join the

books for parents written by divisional members

we welcomed one new full-time faculty, Dr. Zia Bismilla.

Ontario MOH expert panel on complex care in children.

(Caring for Kids, 2006 and Canada’s Baby Care, 2007)

After completing her residency with her final year as

On the clinical side, a dedicated inpatient complex

and edited by Drs. Friedman and Saunders, are both

associate chief resident, Zia was accepted into the

care team now operates four to six beds and is staffed

Canadian bestsellers and on sale internationally as well.

Paediatric Medicine fellowship. During her two-year

by a hospitalist with complex care expertise and a

fellowship, she successfully completed her Masters of

nurse practitioner. The ambulatory arm of the complex

This has been a successful year with regards to

Education at OISE and was also resident editor of the

care team has just begun taking referrals through

research productivity. There were over 20 abstracts

11th Edition of the SickKids Handbook. Her major

ARMs, although capacity remains limited at this time.

from the division at the annual PAS and CPS meetings,

academic interest is in the area of simulation, and she

The hospital has helped fund a proposed pilot project

including many platform presentations. Funding from

presented her research at the CPS and PAS meetings.

to study a new model of care, whereby a medical home

both internal and external agencies was secured,

for the most complex multi-system patients with high

including a number of CIHR grants. PORT, under the

Our part-time inpatient hospitalist group has grown

resource requirements would be developed in their

leadership of Dr. Patricia Parkin, was funded by the

and now includes Drs. Ronik Kanani (NYGH), Yehuda

community hospitals in collaboration with the SickKids

SickKids Foundation for a further five-year term. Many

Mozes (SCH), Ivor Margolis and Sanjeev Luthra

program. The Norman Saunders Complex Care

manuscripts were published in top general paediatric

(WOMC), Tony Barozzino, Mike Sgro and Ethel Ying

Initiative will award its first research grants after

journals (see below).

(St. Mike’s). These individuals, who function as

the inaugural annual competition this summer. Once again, the residents identified their general

hospitalists/consultants at their ‘home’ hospitals, each provide us with two to four weeks of inpatient

Faculty members continued to excel and gain

paediatric ward rotation as their best experience of

attending every six months, connecting our tertiary

recognition as leaders in the field of paediatric medicine.

the year, and many faculty members were recognized

care group more closely to the community and the

Dr. Robert Hilliard was elected to the position of VP

with teaching awards (see below). Special mention

care provided outside of SickKids. Their contribution

of the Canadian Paediatric Society, and will serve as

to Dr. Stacey Bernstein, who won the prestigious

is much appreciated. A formal fellowship in

president in two years time. Dr. Sanjay Mahant was

University of Toronto WT Aikins Award, and Dr. Eyal

Community Paediatrics has been developed under

elected president of the Hospital Medicine section

Cohen for winning the Department of Paediatrics

the leadership of Dr. Mark Feldman, with the support

at the CPS, while Dr. Mark Feldman is the current

Harry Bain Award.

of the Department of Paediatrics at SickKids, and

president of the Community Paediatrics

the first fellow will start her training in 2009.

Dr. Yehuda Nofech-Mozes Dr. Gary Sibbald Dr. Ethel Ying

ADJUNCT Dr. Peter Azzopardi Dr. Ranjit Baboolal

Dr. Anna Banerji Dr. Bert Cellupica Dr. Patricia Colangelo Dr. Hilary de Veber Dr. Paul Dick Dr. Suhid (Tony) D’Souza Dr. Michelle Farine

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Claudio Fregonas Gerald Friedman Marvin H. Gans Hartley A. Garfield Morton Goldbach Leslie Goodis Stuart Gordner

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Michelle Gordon Masoud Grouhi James D. Hilton Tommy Ho Alan P. Hudak Anthony Y.T. Hui Edward G. Jin

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Beverley Kupfert Eddy Lau Cinda B.S. Lee Maurice Levy Aubrey Maze Anilkumar Menon Saba Merchant

Dr. Dr. Dr. Dr. Dr. Dr. Dr.

Steven Moss Larry B. Pancer John Philpott S. Joseph Porepa Vladimir Pucholt Percy Rajchgot Harkamal Randhawa

The Hospital for Sick Children 2007-08 ANNUAL REPORT 141

HONOURS AND AWARDS

Weinstein M: James C. Fallis Teaching Award, Invited

Beck C, Parkin P, Friedman JN: Pediatric hospitalist

Bernstein S: WT Aikins Award for Individual Teaching

Speaker, Division of Paediatric Emergency Medicine,

medicine: an overview and a perspective from Toronto,

Performance, University of Toronto, 2008.

The Hospital for Sick Children, 2008.

Canada. Clinical Paediatrics 2008: 47(6): pp 546-548.

Cohen E: Harry Bain Award for excellence in teaching

PUBLICATIONS

Beck CE: Hypotonic versus isotonic maintenance

by a full-time member of the Department of

Agha M, Glazier R, Guttmann A: Social inequalities

intravenous fluid therapy in hospitalized children:

Paediatrics, University of Toronto, 2008.

affect ambulatory care sensitive hospitalizations

a systematic review. Clinical Pediatrics 2007: 46:

for up to nine years among children born in a major

pp 764-770.

Feldman M: Co-winner of the St. Joseph’s Health Centre

Canadian urban centre. Ambulatory Pediatrics

interdepartmental Best Clinical Teacher Award, 2007.

2007: 7: pp 258-262.

Bismilla Z, Sell E, Donner E: Hashimoto’s encephalopathy. Journal of Child Neurology 2007: 22(7): pp 341-346.

Lansang P, Pope E, Weinstein M: Alvin Jacobs’

Aljaser F, Weinstein M: A one-week-old newborn with

Resident/Fellow Research Award. Growth outcomes

hypercalcemia and palpable nodules: subcutaneous

Chiu PL, Azzie G, Hilliard RI, Fecteau A: Experience

of infants with hemangiomas treated with systemic

fat necrosis. Canadian Medical Association Journal

of moral distress among pediatric surgery trainees.

steroids. Society for Pediatric Dermatology Annual

2008: 178(13):1653-4.

Journal of Pediatric Surgery 2008: 43(6): pp 986-993.

Meeting, Chicago, IL, 2007. Au H, Harrison M, Ahmet A, Orsino A, Beck CE,

Cohen E, Friedman J, Nicholas D, Adams S,

Lau E: Undergraduate Community Paediatric Teaching

Tallett S, Gans M, Birken CS: Residents as Health

Rosenbaum P: A home for medically complex children:

Award, Department of Paediatrics, University of

advocates: the development, implementation

the role of hospital programs. Journal for Healthcare

Toronto, 2008.

and evaluation of a child advocacy initiative at the

Quality 2008: 30: pp 7-15.

University of Toronto. Paediatrics and Child Health Pope E: Promoted to Associate Professor, Department

Cohen E, Navarro O: Silent aspiration. Pediatrics

2007: 12: pp 567-571.

in Review 2007: 28: pp 419-425.

of Paediatrics, University of Toronto, 2008. Barrera M, D’Agostino N, Schneiderman G, Tallett S, Tallett S: The Mickles Fellowship Award,

Spencer L, Jovcevska V: Patterns of parental

Cohen E, Weinstein M, Fisman DN: Cost effectiveness

University of Toronto, 2007.

bereavement following the loss of a child and related

of competing strategies for the treatment of pediatric

factors. OMEGA 2007: 55(2): pp 145-167.

empyema. Pediatrics 2008: 121: pp e1250-e1257.

Dr. Douglas Campbell Dr. Carlos E. Contreras Dr. Leona Fishman Dr. John S. Freedman Dr. Lee Ann Gallant Dr. Beth D. Gamulka Dr. Rose Geist

Dr. Golda Milo-Manson Dr. Jay D. Rosenfield Dr. Suzanne Schuh Dr. Jeffrey J. Weisbrot Dr. Sheldon A. Wise

Dr. Rahul Saxena Dr. Clive J. Schwartz Dr. David H. Shawn Dr. Angelo Simone Dr. William Gary Smith Dr. Joseph Telch Dr. Guy Widrich

Dr. Peter D. Wong Dr. Heather Yang

CROSS-APPOINTEES Dr. Glen B. Berall Dr. Alan Berzen Dr. Bonnie J. Cameron

142 The Hospital for Sick Children 2007-08 ANNUAL REPORT

Dr. Sabine R. George Dr. Nicole G. Inch Dr. D. Anna Jarvis Dr. Ian C. Kitai Dr. Leo Levin Dr. Patricia M. Linders Dr. John S. Lovering

HONORARY Dr. Lionel B.H. Boxall Dr. Andrew Chlebus Dr. William Davidson Dr. Till A. Davy Dr. Gordon J. Donsky Dr. James Dorey

Cohen E, Zlotnik-Shaul R: Beyond the therapeutic

Ipp M, Taddio A, Sam J, Goldbach M, Parkin PC:

Mahant S, Peterson R, Campbell M, MacGregor DL,

orphan: children and clinical trials. Pediatric Health

Vaccine-related pain: randomised controlled trial

Friedman JN: Reducing inappropriate hospital days on

(invited submission) 2008: 2(2): pp 151-161.

of two injection techniques. Archives of Diseases

a general paediatric inpatient unit. Pediatrics 2008:

of Childhood 2007: 92: pp 1105-1108.

121:(5): e1068-e1073.

Kanani R, Mohamed M: Case 1: the case of the

Metry DW, Siegel DH, Cordisco MR, Pope E,

Finan E, Mak W, Bismilla Z, McNamara PJ: Early discontinuation of intravenous prostaglandin E(1) after balloon atrial septostomy is associated with

irritable nephritic. Paediatrics and Child Health 2008:

Prendiville J, Drolet BA, Horii KA, Stein SL, Frieden IJ:

an increased risk of rebound hypoxemia. Journal

13(2): pp121-122.

A comparison of disease severity among affected male versus female patients with PHACE syndrome.

of Perinatology 2008: 28(5): pp 341-346. Lam J, Pope E: Pityriasis lichenoides and cutaneous

The Journal of the American Academy of Dermatology

Guttmann A, Manuel D, Stukel T, DeMeules M, Cernat

T-cell lymphoma in paediatrics. Current Opinion in

2008: 58(1): pp 81-87.

G, Glazier R: Immunization coverage among young

Pediatrics 2007: 19(4): pp 441-445. O’Brodovich H, Beyene J, Tallett S, MacGregor D,

children of immigrant mothers in Ontario, Canada. Ambulatory Pediatrics 2008: 8(3): pp 205-209. Guttmann A, Zagorski B, Austin P, Schull M, Razzaq A,

Maguire J, DeVeber G, Parkin PC: The association

Rosenblum N: Performance of a career development

between iron deficiency anaemia and stroke in young

and compensation program at an academic health

children. Pediatrics 2007: 120: pp 1053-1057.

science centre. Pediatrics 2007: 119: pp e791-e797.

To T, Anderson G: Effectiveness of emergency department asthma management strategies on return visits in children: a population-based study. Pediatrics 2007: 120: pp e1402-e1410. Hawkes M, Kitai I, Blaser S, Cohen E, Bitnun A,

Dr. Stacey Bernstein and team

Fluss J, Tran D: Neuroimaging findings in isoniazid toxicity, presumed intramyelinic edema. European Journal of Pediatric Neurology 2008: February 1 [Epub ahead of print].

Dr. Katy Driver Dr. Andrew D. Duic Dr. Anthony S.R. Duke Dr. Thomas J. Egan Dr. Robert Farber Dr. Hyder H. Fazal Dr. William Feldman

Dr. Adelaide L. Fleming Dr. Raphael Folman Dr. Katerina Haka-Ikse Dr. William B. Hanley Dr. Dirk W. Huyer Dr. Jaya Islur Dr. Martin H. Kosoy

Dr. Howard M. Langer Dr. Michael Lester Dr. David C. Maresky Dr. Marcellina Mian Dr. Gilbert Miller Dr. Janette A. Milne Dr. Paul Munk

Dr. John D.M. Murray Dr. Jack Newman Dr. Raymond C.W. Ng Dr. Evangelia Papadouris Dr. Helene A. Richards Dr. Chandrakant P. Shah Dr. Donald Stewart

Dr. Peter G. Strachan Dr. Robert E. Sutton Dr. Martin G. Wolfish

FELLOWS Dr. Sara Abed Dr. Alexandra Balma-Mena

Dr. Zia Bismilla Dr. Malini Dave Dr. Irene Lara Corrales Dr. Perla Lansang Dr. Jonathon Maguire Dr. Michael McNeely Dr. Ma. Lourdes Palmero

The Hospital for Sick Children 2007-08 ANNUAL REPORT 143

O’Connor D, Khan S, Vaughan J, Weishuhn K, Jefferies

Tallett S, Lingard L, Leslie K, Pirie J, Jefferies A, Spero

Friedman JN, Saunders NR: Canada’s Baby Care Book.

A, Campbell D, Asztalos E, Feldman M, Rovet J,

L, Schneider R, Hilliard R, Rosenfield J, Hellmann J,

Robert Rose Publishing, Toronto, 2007.

Westall C, Whyte H: Growth and nutrient intakes

Mian M, Hurley J: Measuring educational workload.

of human milk-fed premature infants provided with

Medical Teacher 2008: 30(3): pp 296-301.

Friedman JN: Technologic devices in the medically complex child. In: Comprehensive Pediatric Hospital

extra energy and nutrients after hospital discharge. Pediatrics 2008: 121: pp 766-776.

Wendtlandt K, Beck CE: A child with gastrointestinal

Medicine (Zaoutis LB, Chiang VW, eds.). Elsevier

bleeding. Paediatrics and Child Health 2007: 12:

Science, Philadelphia, 2007.

Seltz LB, Kanani R, Zamakhshary M, Chiu PPL: A

pp 869-870. Landrigan C, Friedman JN: Patient safety and medical

newborn with chylous ascites caused by intestinal malrotation associated with heterotaxia syndrome.

BOOKS AND BOOK CHAPTERS

errors. In: Comprehensive Pediatric Hospital Medicine

Pediatric Surgical International 2008: 24: pp

Adams SL, Mahant S: Introduction to the medically

(Zaoutis LB, Chiang VW, eds.). Elsevier Science,

633-636.

complex child. In: Comprehensive Pediatric Hospital

Philadelphia, 2007.

Medicine (Zaoutis LB, Chiang VW, eds.). Elsevier Inc, Serletis D, Bouffet E, Parkin P, Rutka J, Drake J, Shroff

Weinstein M: Lower respiratory tract infections.

Philadelphia, 2007.

M: Massive plexiform neurofibromas in childhood:

In: Comprehensive Pediatric Hospital Medicine

natural history and management issues. Journal of

Bernstein S: Systemic lupus erythematosus. In:

(Zaoutis LB, Chiang VW, eds.). Elsevier Science,

Neurosurgery 2007: 106(5 Suppl): pp 363-367.

Comprehensive Pediatric Hospital Medicine (Zaoutis L,

Philadelphia, 2007.

Chiang V, eds.). Elsevier Inc., Philadelphia, 2007.

RESEARCH FUNDING

Taddio A, Manley J, Potash L, Ipp M, Sgro M, Shah V: Routine immunization practices: use of topical

Friedman JF, Beck CE: Parenteral fluid therapy for

An exclusively community-based clerkship in

anaesthetics and oral analgesics. Pediatrics 2007:

infants and children. In: Conn’s Current Therapy

paediatrics compared with a paediatric academic

120: pp 630-631.

2008 (Rakel RE, Bope ET, eds.). Elsevier Inc.,

health science centre. Feldman M. Paediatric

Philadelphia, 2008.

Consultants Partnership’s Grant ($5,000 2007-2008)

Dr. Adam Rapoport Dr. Leonard Barry Seltz Dr. Navneet Sharma Research Associates Deepa Dalal Spring Holter Vesna Jovcevska

Amina Khambalia Kayi Li Noorulain Malik Magda Mekky Dr. Jyothi Sehgal Kathryn (Kate) Smith Vineet Syan

144 The Hospital for Sick Children 2007-08 ANNUAL REPORT

Catherine Wong Ming Yang

ADMINISTRATIVE STAFF Sarah Ahmad Tiziana Altobelli Josie Marcantonio

Marg Mather Daffodil Morrison Kathryn Robertson Pauline Smith Jan White Donna Whitely

A prospective study on the age of onset, incidence,

CIHR Emerging Team in Childhood Obesity Research.

Evaluation of the efficacy and safety of imiquimod 5%

geographic distribution and risk factors associated

McCrindle B, Parkin P, Pencharz P, Hamilton J,

topical cream in plaque morphea: a prospective,

with atopic dermatitis. Pope, E, Krafchik BR, Pelletier J.

Anderson G, Birken C, Wells G, Riddell M, Hanley A,

multiple baseline, open label pilot study. Pope E, Laxer

Canadian Dermatology Foundation ($35,000

O’Connor D, Dettmer E, Bellisimo N, Langer J, Tein I.

R, Doria A, Feldman B, Babyn P: 3M Inc/Graceway

1996-2007)

Canadian Institutes of Health Research ($2,452,522

Pharmaceuticals Canada ($29,500 2005-2008)

2008-2013) Evaluation of the emergency department general

A randomized, prospective, double-blind placebocontrolled clinical study assessing the efficacy

Complementary medicine in Canadian paediatric

internal medicine patient flow toolkit. Schull M,

of topical tacrolimus 0.1% ointment and topical

patients with atopic dermatitis: a cross-sectional

Guttmann A. Ministry of Health and Long-Term Care

clobetasol propionate 0.05% ointment in the

survey. Weinstein M, Pope E, Redlick F. Canadian

($1,133,400 2007-2011)

treatment of vitiligo. Ho N, Krafchik BR, Pope E,

Dermatology Foundation ($10,000 2006-2008) Examining the impact of primary care reform in

Greenberg S, Webster C, Weinstein M. Fujisawa Developing quality and safety indicators for Canada’s

Ontario on access to and quality of care. Glazier R,

emergency departments. Schull M, Guttmann A.

Guttmann A. Canadian Institutes of Health Research

Canadian Institutes of Health Research ($20,000 2008)

($833,400 2008-2011)

Birken CS, Beck CE, McCrindle B, Parkin PC.

Does the order in which vaccines are administered

Genetic analysis of PHACE(S) association. An

Paediatric Consultants Partnership’s Grant ($9,975

affect pain response? A randomized, double-blind,

international registry based out of the University of

clinical trial of Pentacel versus Prevnar. Ipp M, Taddio

California, San Francisco. Frieden IJ, Pope E, Siegel D:

Canada Inc. ($62,425 2004-2007) An office based intervention to improve media use in preschool children: a randomized controlled trial.

2007-2008) Career enhancement. Guttmann A Canadian Child

A, Lear N, Goldbach M, Parkin PC. Sanofi Pasteur

University of Southern California at San Francisco

($17,250 2006-2007)

($20,000 2006-2009)

Health Clinician Scientist Program ($25,000 2007-2012)

Emergency department rapid intravenous rehydration

Image guided GJ-tube versus laparoscopic nissen

(RIVR) for paediatric gastroenteritis: a randomized

fundoplication with gastrostomy in neurologically

controlled trial. Freedman SB, Parkin P, Willan AR,

impaired children with gastroesophageal reflux: a

Schuh S. Physicians’ Services Incorporated

study examining health-related quality of life. Langer

Foundation ($156,000 2006-2008)

JC, Mahant S, Connolly B, Friedman JN, Nicholas D, Wales P, Ungar W, Pastor A. Ontario Federation for Cerebral Palsy ($29,097 2007-2009)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 145

Impact of oximetry on hospitalization in acute

Low versus high fidelity simulation in neonatal

Nutritional education and the prevention of iron

bronchiolitis. Schuh S, Freedman S, Coates A,

resuscitation training. Whyte H, Bismilla Z, Finan E,

depletion in children nine months to two years:

Parkin PC, Allen U, Willan A, Ungar W, Da Silva Z.

McNamara P. Paediatric Consultants Partnership’s

a randomized controlled trial. Parkin PC, Maguire J,

Physicians’ Services Incorporated Foundation

Grant ($5,000 2007-2008)

Khambalia A, Jacobson S, Peer M. Danone Institute ($61,148 2006-2008)

($163,000 2007-2009) Magnesium for Sickle Cell Trial (MAST). Goldman R, International registry of paediatric cutaneous T-cell

Mounstephen W, Kirby M, Friedman JN. Physicians’

Open label extension study to determine safety

lymphoma: a longitudinal, prospective, observation

Services Incorporated Foundation ($163,846

of etanercept in paediatric subjects with plaque

study of cutaneous T-cell lymphoma in the paediatric

2005-2008)

psoriasis. Pope E, Weinstein M. Amgen Inc. ($43,000 2006-2007)

population. Pope E, Weinstein M, Weitzman S, Taylor G. Canadian Dermatology Foundation ($10,000

Measuring the quality of hospital care for children

2004-2009)

and youth in Canada. Guttmann A, Matlow A, Moore C, Parshuram C, Stukel T, To T. Canadian Institutes

NF1-associated malignancy. Lewis S, Parkin P.

International registry of paediatric cutaneous T-cell

of Health Research ($25,000 2007-2010)

The Hospital for Sick Children Research Institute

Palindromy at the NF1 locus as a risk factor for

New Ideas Grant ($45,023 2006-2009)

lymphoma: a longitudinal, prospective, observation study of cutaneous T-cell lymphoma in the paediatric

Measuring the quality of hospital care for children

population. Pope E. University of Toronto Dean’s

and youth in Canada. Guttmann A. Ontario Ministry of

Paediatric outcomes research. Parkin PC, Macarthur C.

Fund New Staff Grants ($10,000 2004-2009)

Health and Long-Term Care ($300,000 2007-2010)

SickKids Foundation ($750,000 2008-2012)

Is prolonged bottle feeding an independent risk for

Measuring the quality of hospital care for children

Pilot study of a lifestyle program in children receiving

overweight in young children? Birken CS, Parkin PC,

and youth in Canada. Guttmann A. Canadian

treatment for acute lymphoblastic leukaemia (ALL).

O’Connor D, Jacobson S, Peer M, Mekky M. University

Institutes of Health Research ($75,000 2008-2011)

Nathan P, Wright M, Collins L, Birken CS, Dettmer E.

Modifiable risk factors for acute chest syndrome in

Grant ($14,000 2008-2009)

Paediatric Oncology Group of Ontario Seed Funding

of Toronto Dean’s Fund New Staff ($9,972 2008-2013) Isotonic versus hypotonic IV maintenance fluid in

children with sickle cell disease admitted to hospital

children: a randomized controlled trial. Friedman JN.,

with a painful crisis. Birken CS, Khambalia A, Dekker

Freedman S, Beck C, Geary D. Paediatric Consultants

A, Pastor A, Lee M, Padavattan K, Parkin PC. Paediatric

Partnership’s Grant ($9,956 2007-2008)

Consultants Partnership’s Grant ($3,750 2007-2008)

146 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

The efficacy of trimethoprim in wound healing of

Presentation, management and outcomes evaluation

Teaching intubation to residents: standard mannequin

of children with vascular tumours. (Vascular

versus high fidelity simulation. Whyte H, Bismilla Z,

patients with epidermolysis bullosa: a randomized

Tumour Registry). Pope E, Mahant S, Blanchette V,

Finan E, Jefferies A, LeBlanc V. Physicians’ Services

double-blinded, placebo-controlled, cross-over pilot

Weitzman S, Baruchel S, John P, Brandao L. Paediatric

Incorporated Foundation ($17,000 2007-2008)

study. Pope, E, Lara-Corrales I, Weinstein M, Parkin P, Sibbald G. Canadian Dermatology Foundation

Consultants Partnership’s Grant ($9,900 2006-2009) The effectiveness of the paediatric sedation device:

($10,000 2007)

Genetic determinants of influenza severity in children:

pilot study for randomized controlled trial. Brown SC,

A pre-pandemic community-based feasibility study.

Schneeweiss S, McGrath PA, Pope E. National

Treatment choices for children with typical acute

Tran D, Beyene J, Bitnun A, Paterson A, Richardson S,

Institutes of Health ($159,062 2005-2008)

immune thrombocytopenic purpura: development of a decision aid. Beck C, Birken CS, Blanchette V,

Ipp M. Canadian Institutes of Health Research ($99,919 2008-2009)

The efficacy of trimethoprim in wound healing of

Boydell K, Llewellyn-Thomas H, Parkin PC. University

patients with epidermolysis bullosa: a randomized,

of Toronto Dean’s Fund New Staff Competition ($10,000 2006-2011)

Short- and long-term outcomes of complicated

double-blinded, placebo-controlled, cross-over pilot

paediatric pneumonia. Weinstein M, Cohen E, Dell S,

study. Pope E, Lara-Corrales I, Weinstein M, Parkin P,

Mahant S, Traubici J, Mekky M. University of Toronto

Sibbald G. Dystrophic Epidermolysis Bullosa

Dean’s Fund New Staff Grant ($10,000 2007-2008)

Waiting with an emergency. Schull M, Guttmann A.

Recessive Association of Canada (dEBra Canada)

Canadian Health Services Research Foundation

($10,000 2006-2008)

($400,000 2007-2010)

Sickle cell disease in children: osteomyelitis or vaso-occlusive crises? Berger E, Saunders N, Khambalia A, Friedman JN. SickKids Trainee Start-up Fund ($3,000 2007-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 147

Division of

Dr. Theo Moraes

DIVISION HEAD Dr. Felix Ratjen FULL-TIME Dr. Allan L Coates Dr. Sharon Dell Dr. Hartmut Grasemann Dr. Indra Narang

Dr. Melinda Solomon Dr. Padmaja Subbarao Dr. Neil B Sweezey

PART-TIME Dr. Peter Bikangaga Dr. James MacFarlane Dr. Theo Moraes Dr. Charlotte D’E. Miller

ADJUNCT SCIENTIST Dr. Hiran Selvadurai CROSS-APPOINTEES Dr. T. Douglas Bradley Dr. Theodore Marras

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

HONORARY FACULTY Dr. Dennis Gurwitz Dr. Elizabeth Tullis

FELLOWS Dr. Dimas Mateos-Corral Dr. Harutai Kamalaporn Dr. Mustafa Osman Dr. Reshma Amin Dr. Sintra Phumethum Dr. Suhail Al-Saleh

SUBSPECIALTY RESIDENTS Dr. Joanna Swinburne Dr. Tania Samanta Dr. Tara Allen ADMINISTRATIVE STAFF Tara Beattie Jennifer Chay Victoria Snell

Division of Respiratory Medicine OVERVIEW

As part of the Toronto Lung Transplantation Program,

inflammation and infection in cystic fibrosis, effect of

The Division of Respiratory Medicine continues to

the division provides pre- and post-transplantation

sex hormones in airway inflammation, defining the role

provide comprehensive care for the full range of

care for children with end-stage lung disease. The

of novel genes in lung development, studies in aerosol

paediatric pulmonary diseases such as asthma, cystic

lung transplant program continues to be the largest

therapy and exercise physiology. Dr. Subbarao has

fibrosis (CF), interstitial lung fiseases, primary ciliary

paediatric lung transplant program in the country.

become the co-principal investigator of a large birth cohort study to elucidate the factors important for the

dyskinesia (PCD), hereditary hemorrhagic telangiectasia (HHT), sleep-related disorders of breathing and complex

The training program has independent Royal College

development of asthma in early childhood that is

respiratory care requiring ventilatory support, as well as

of Physicians and Surgeons of Canada accreditation

supported by CIHR and partners such as AllerGen.

children with congenital malformations involving the

and is the largest training program for paediatric

respiratory tract. We provide consultation support for

respiratory medicine in the country. It provides the full

the hospital in all areas of paediatric respiratory

range of training that is required for board certification

NIH-funded childhood asthma management program

disease. The division provides diagnostic services

in paediatric pulmonology in the United States. As well

continuation study (Dr. Grasemann, Dr. Subbarao).

including flexible bronchoscopy.

as offering training to Royal College of Physicians and

There has also been a growing interest in assessing

Over the last year, we have broadened our diagnostic

The division also continues to be involved in the

Surgeons of Canada eligible candidates, the division

the pulmonary sequelae of sickle cell disease that are

also trains physicians from abroad.

currently being addressed in a number of research studies (Dr. Grasemann, Dr. Narang, Dr. Subbarao).

spectrum of tests to assess diseases with airway inflammation, including testing of nitric oxide in

Dr. Theo Moraes, who completed his PhD in Dr. Gregory

Dr. Allan Coates and Laura Seed have been very active

exhaled air as well as gas mixing techniques as more

Downey’s laboratory and subsequently worked with

on both the provincial and national level with the Ontario Lung Association and the Canadian Thoracic

sensitive tests for obstructive airway diseases. The

Dr. Tanja Watts, has joined our division as a clinician-

addition of an infant pulmonary function laboratory

scientist. His research is directed towards a better

Society by promoting training of spirometry in children

has broadened the potentials for diagnostic tools to

understanding of processes driving lung inflammation,

and acting in advisory roles for research studies using

objectively assess lung disease in infants and young

as well as immunological mechanisms involved in

lung function testing with Statistics Canada.

children, and is available for the assessment of both

immunity against respiratory viruses. There is a broad

inpatients and outpatients. The infant pulmonary

spectrum of both basic science and clinical research

function lab is the only laboratory in the country

that bridges the laboratory to the clinic in many

offering this service. We are currently in the process

disease areas. The major research foci include clinical

of closing the gap by developing pulmonary function

and epidemiological studies in patients with asthma

tests for preschool children as well.

and cystic fibrosis, translational studies on airway

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 149

Dr. Dell is involved in an international program to

Dr. Ratjen and the CF group are involved in multiple

For a more complete description of our clinical activities,

develop a new classification for interstitial lung

studies in a leading role, including multicentre studies

educational events and research interests, please visit

diseases and a NIH-sponsored study on primary ciliary

on azithromycin in Pseudomonas negative CF patients.

the division of respiratory medicine website as well as

dyskinesia. Dr. Dell, in collaboration with researchers

This is the first Canada-U.S. study funded by the U.S.

the website CF centre.

from the University of California in Berkeley, is also

CF foundation on the role of aspergillus infection in CF.

leading a study examining the association between

Funded by the Canadian CF foundation and Physicians’

PUBLICATIONS

asthma and traffic-related air pollution in Toronto

Services Incorporated Foundation and on the use of

Al-Saleh S, Grasemann H, Cox P: Necrotizing pneumonia

school-age children. Dr. Solomon is studying the

hypertonic saline as an early intervention strategy

complicated by early and late pneumatoceles. Canadian

cognitive-behavioural aspects of teaching communication

funded by the US CF foundation and the NIH. Dr.

Respiratory Journal 2008: 15: pp 129-132.

supported by an educational development grant from

Grasemann is leading a series of studies to elucidate

the Centre of Faculty Development.

the role of arginase and NO deficiency in CF lung disease

Amin R, Ratjen F: MRI: the next frontier for cystic

sponsored by CIHR and the Canadian CF foundation.

fibrosis clinicians? Expert Review of Respiratory

In addition, members of the division are key partners of

Medicine 2008: 2(2): pp 179-182.

the CF team that has formed the Cystic Fibrosis Centre,

The division is also involved in developing new

highlighting the longstanding and ongoing excellence in

outcomes measures to assess improvement in CF

Belik J, Shehnaz D, Pan J, Grasemann H:

both clinical care and research at SickKids in this area.

lung disease within the BREATHE program, a study

Developmental changes in arginase expression

Newborn screening for cystic fibrosis was started this

to develop CFTR corrector therapy (Dr. Ratjen). Other

and activity in the lung. American Journal

year and the CF team at SickKids was a driving force

studies supported by research grants, as well as

of Physiology–Lung, Cellular and Molecular Physiology 2008: 294: pp L498-L504.

in getting this off the ground. Dr. Ratjen acts as a

generous support by individuals such as the Irwin

medical advisor to the screening group in Ottawa and

family, are ongoing, in addition to industry sponsored

a collaborative study with Dr. Durie as the principal

studies. One is an 80-site study on denufosol, a P2Y

Brenden C, Danziger-Isakov LA, Astor T, Aurora P,

investigator will be started to evaluate the clinical

receptor agonist that activates chloride conductance

Bluemchen K, Boyer D, Conrad C, Eichler I, Elidemir O,

course of patients with an unclear diagnosis within

through alternative chloride channels (Dr. Ratjen, PI).

Goldfarb S, Michaels MG, Mogayzel PJ, Mueller C,

the Newborn Screening Program.

The CF group is also involved in other clinical studies

Parakinikas D, Oberkfell D, Solomon M, Boehler A:

of drugs targeting the basic defect in CF. A close

Variability in immunization guidelines in children

collaboration exists with the adult CF program at St.

before and after lung transplantation. Pediatric

Michael’s Hospital led by Dr. Tullis, in both clinical

Transplantation 2007: 11: pp 882-887.

care and many areas of research, and with the Lung Transplant Team at Toronto General led by Dr. Keshavjee.

150 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Grasemann H, Gerard NP, De Sanctis GT: Ventilatory

Coates AL, Green M, Leung K, Louca E, Tservistas M,

Dell SD, Becker A, Chapman K, Foty R, Franssen E:

Chan J, Ribeiro N, Charron M: The challenges of

Are symptom-based criteria enough to define asthma

responses to acute hypoxia in neurokinin-1 receptor

quantitative measurement of lung deposition using

control in children? A population-based cross-

deficient mice. Respiratory Physiology and Neurobiology 2007: 159: pp 227-231.

99mTc-DTPA from delivery systems with very different

sectional analysis comparing adult and pediatric

delivery times. Journal of Aerosol Medicine 2007:

asthma outcomes. Pediatric Pulmonology 2007:

20: pp 320-330.

42: pp 1117-1124.

Lakeman P, Gille JJP, Dankert-Roelse JE, Heijerman

Coates AL: Guiding aerosol deposition in the lung.

Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD,

Cornel MC, ten Kate LP: CFTR mutations in Turkish

New England Journal of Medicine 2008: 358:

Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston

and North African cystic fibrosis patients in Europe:

HGM, Munck A, Iron A, Grasemann H, Schuster A,

pp 304-305.

C, and the Pathology Co-operative Group: Diffuse lung

implications for screening. Genetic Testing 2008:

disease in young children: application of a novel

12: pp 25-35.

Coates AL, Green M, Leung K, Chan J, Ribeiro N, Louca

classification scheme. American Journal of Respiratory

E, Ratjen F, Charron M, Tservistas M, Keller M: Rapid

and Critical Care Medicine 2007: 176: pp 1120-1128.

Nikolaizik WH, Vietzke D, Ratjen F: A pilot study to compare tobramycin 80 mg injectable preparation

pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot project.

Duong M, Subbarao P, Adelroth E, Otis J, Obminski G,

with 300 mg solution for inhalation in cystic fibrosis

Pediatric Pulmonology 2008: 43(8): pp 753-759.

Strienich T, Inman M, Pedersen S, O’Byrne PM:

patients. Canadian Respiratory Journal 2008: 15(5):

Sputum eosinophils and the response of exercise-

pp 259-262.

Corral DM, Coates AL, Yau YC, Tellier R, Glass M,

induced bronchoconstriction to corticosteroid in

Jones SM, Waters VJ: Burkholderia pseudomallei

asthma. Chest 2008: 133(2): pp 404-411.

Narang I, Rosenthal M, Bush A: Reproducibility of cardioventilatory measurements using a respiratory

infection in a cystic fibrosis patient from the Caribbean: a case report. Canadian Respiratory

Grasemann C, Ratjen F, Reutershahn E, Vester U,

mass spectrometer. Respiratory Physiolology &

Journal 2008: 15(5): pp 237-239.

Schnabel D, Grasemann H: Effect of growth hormone

Neurobiology 2007: 157: pp 310-315.

therapy on nitric oxide formation in patients with Davis SD Ratjen F: Editorial: Reduced lung function in

cystic fibrosis. European Respiratory Journal 2008:

Nemati B, Atmodjo W, Kaplan F, Sweezey NB:

cystic fibrosis: a primary or secondary phenotype?

4: pp 815-821.

Glucocorticoid receptor disruption delays structural

American Journal of Respiratory and Critical Care

maturation in the lungs of newborn mice. Pediatric

Medicine 2008: 178(1): pp 2-3.

Pulmonology 2008: 43(2): pp 125-133.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 151

Quinlan J, Kaplan F, Sweezey NB, Goodyer P: LGL1,

Stanojevic S, Wade A, Stocks J, Hankinson J, Coates

Waters V, Ratjen F: Combination antimicrobial

a novel branching morphogen in developing kidney,

AL, Pan H, Rosenthal M, Corey M, Lebecque P, Cole

susceptibility testing for acute exacerbations in

is induced by retinoic acid. American Journal of

TJ: Reference ranges for spirometry across all ages:

chronic infection of Pseudomonas aeruginosa in

Physiology - Renal Physiology 2007: 293(4):

a new approach. American Journal of Respiratory and

cystic fibrosis. Cochrane Database Systematic

pp F987-F993.

Critical Care Medicine 2008: 177: pp 253-260.

Reviews 2008: 3: CD006961.

Ratjen F: Aerosol therapy in cystic fibrosis:

Subbarao P, Balkovec S, Solomon M, Ratjen F: Pilot

Wells G, Wilkes D, Schneiderman-Walker J, Elmi M,

weighing the evidence. Pediatric Pulmonology

study of safety and tolerability of inhaled hypertonic

Tullis E, Ratjen F, Coates AL: Reliability and validity

2008: 43(S9): pp S3-S4.

saline in infants with cystic fibrosis. Pediatric

of the habitual activity estimation scale (HAES) in

Pulmonology 2007: 42: pp 471-476. Current Opinion in Pulmonary Medicine 2007: 13(6): pp 541-546. Ratjen F: Recent advances in cystic fibrosis. Paediatric

patients with cystic fibrosis. Pediatric Pulmonology 2007: 43: pp 345-353.

Ratjen F: New pulmonary therapies for cystic fibrosis. To T, Dell S, Dick P, Cicutto L: The burden of illness experienced by young children associated with

BOOKS AND BOOK CHAPTERS

asthma: a population-based cohort study. Journal

Narang I, Balfour-Lynn I: Cardiopulmonary function

of Asthma 2008: 45(1): pp45-49.

testing–paediatrics. In: Physiotherapy for Respiratory

Respiratory Reviews 2008: 9(2): pp 144-148.

and Cardiac Problems, 4th Edition (Pryor J, Prasad A, To T, Gershon A, Wang C, Dell S, Cicutto L: Persistence

Ridder-Schaphorn S, Ratjen F, Hübbers A, Hüberte J,

and remission in childhood asthma: a population-based

Falk S, Küster P, Schuster A, Mellies U, Löwe B,

asthma birth cohort study. Archives of Pediatrics and

Reintjes R, Peters G, Kahl BC: Nasal staphylococcus

Adolescent Medicine 2007: 161(12): pp 1197-1204.

aureus carriage is not a risk factor for lower airway

eds.). Churchill Livingstone, Oxford, UK, 2008. Ratjen F, Tullis E: Cystic fibrosis. In: Clinical Respiratory Medicine, 3rd Edition (Albert RK, Spiro SG, Jett JR, eds.). Mosby Elsevier, St. Louis, MO, 2008.

infection in young cystic fibrosis patients. Journal of Clinical Microbiology 2007: 45(9): pp 2979-2984.

Solomon M, Ross H, Delgado D. Pediatric lung transplantation. In: Lung Transplantation Manual (Chaparro Mutis C, Hutcheon M, Singer L, Keshavjee S. eds.). Elsevier, Toronto, 2007.

152 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

FUNDING

CAMP-CS3: The Hospital for Sick Children Clinical

Effect of increased L-arginine bioavailability on

A multi-stage population based study to determine

Centre for Study of a Childhood Asthma Management

cystic fibrosis lung disease. Grasemann H, Ratjen F,

the association between air pollution and asthma.

Program - continuation study, part 3. Subbarao P,

Pencharz P, Scott J. Canadian Cystic Fibrosis

Dell S. Health Canada ($79,000 2007-2009)

Grasemann H, Solomon M. John Hopkins University

Foundation ($39,869 2007-2009)

Centre for Clinical Trials/National Institutes of A pilot study to evaluate the tolerability of inhaled

Effect of increased L-arginine bioavailability on

Health National Heart, Lung and Blood Institute

7% hypertonic saline in infants with cystic fibrosis

cost-reimbursement contract grant (US$370,633

Pseudomonas aeruginosa infection of the lung in

(ISIS-001). Ratjen F. US CF Foundation ($10,878

2008-2011)

cystic fibrosis. Grasemann H, Ratjen F, Pencharz P, Scott J. Canadian Institutes of Health Research

2007-2008) Canadian birth cohort: Indoor air and the development

($100,000 2007-2009)

A randomised double-blind, placebo-controlled

of asthma and allergy (CHILD study). Sears M,

four-way cross over study comparing montelukast,

Subbarao P. Canadian Institutes of Health Research

Effect of Ontario’s universal influenza immunization

inhaled budesonide and their combination to placebo

($12,000,000 2007-2013)

program on influenza-related health-care outcomes.

Characterization of factors and mechanisms affecting

($82,163 2007-2009)

Manuel D, Dell S. Canadian Institutes of Health

on exercise-induced bronchoconstriction. Grasemann H, Subbarao P, O’Bryne P. Merck-Frosst RCT ($207,580 2007-2008) Breathe program–a randomized-controlled trial of

physical activity, muscular function and lung health in cystic fibrosis. Coates AL, Ratjen R. Canadian Cystic

Effect of rhDNase of ventilation in homogeneity in

Fibrosis Foundation ($180,000 2006-2008)

patients with cystic fibrosis. Ratjen F, Subbarao P. Hoffman-La-Roche ($45,000 2007-2008)

inhaled hypertonic saline (7%) to detect a treatment effect using the lung clearance index in CF patients

Diagnosing cystic fibrosis in neonates and adults:

with normal lung function. Ratjen F. Canadian Cystic

where do we draw the line? Durie P, Tullis E, Ratjen F.

Functional analyses of two novel, developmentally-

Canadian Cystic Fibrosis Foundation ($360,000

regulated glucocorticoid responsive genes in fetal

Fibrosis Foundation ($61,654 2007-09)

2008-2011) CAMP-CS2: The Hospital for Sick Children Clinical

lung. Kaplan F, Sweezey N. Canadian Institutes of Health Research ($655,595 2004-2009)

Centre for Study of a Childhood Asthma Management Program – continuation study, part 2. Grasemann H, Solomon M, Subbarao P. John Hopkins University Centre for Clinical Trials/National Institutes of Health/National Heart, Lung and Blood Institute ($631,133 2003-2007)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 153

Glucocorticoid receptor and glucocorticoid-responsive

Modulation by sex hormones of inflammation and

Multicentre, multi-national, randomized, placebo-

genes in developing lung. Sweezey N, Kaplan F.

susceptibility to Pseudomonas aeruginosa in cystic

controlled trial of azithromycin in participants with

Canadian Institutes of Health Research ($563,500

fibrosis airways. Sweezey N. Canadian Cystic Fibrosis

cystic fibrosis, six to 18 years old, culture negative for

2004-2009)

Foundation ($140,000 2007-2009)

Pseudomonas aeruginosa. Ratjen F, Solomon M. Cystic Fibrosis Foundation Therapeutics Inc.

Inhaled saline for infants study (ISIS-002). Davis S,

Modulation by sex hormones of inflammation and

Rosenfeld M, Ratjen F. US CF Foundation (continued

susceptibility to Pseudomonas aeruginosa in cystic

($5,200,464 2006-2009)

funding guaranteed for the complete study duration of

fibrosis airways (salary support for technican).

Pharmacogenomics of P2Y2 receptor activation.

four years through CFF) (US$1,794,674 2007-2008)

Sweezey N. The Lynne and Arnold Irwin Foundation

Ratjen F. Inspire Inc. ($51, 030 2007-2009)

($40,000 2007-2009) Respiratory population-based outcomes network:

Lab technician salary support. Grasemann H. The Lynne and Arnold Irwin Foundation ($25,000 2007-2008)

Mucociliary Clearance Consortium, Rare Diseases

studies and evaluations (RESPONSE). To T, Dell S.

Centre. Site PI: Dell S (main PI: Knowles M, primary

Canadian Institutes of Health ($150,000 2007-2009)

site: Chapel Hill). National Institutes of Health Long-term outcomes after paediatric complicated

($76,958 2007-2008)

and modulates NO synthesis in the cystic fibrosis lung.

pneumonia. Cohen E, Dell S. University of Toronto Dean’s Fund ($10,000 2007-2009)

Surfactant protein D controls inflammatory response

Multicentre, multi-national, randomized, placebo-

Grasemann H (David Douda, PhD student). Ontario

controlled trial of azithromycin in participants with

Student Opportunity Trust Fund/Restracomp ($60,000 2008-2010)

Lung allograft rejection gene expression observational

cystic fibrosis, six to 18 years old, culture negative

study. Solomon M. XDx Expression Diagnostics

for Pseudomonas aeruginosa (PI salary support).

($7,500 2005-2007)

Ratjen F. Cystic Fibrosis Foundation Therapeutics Inc. (US$36,546 2007-2008)

Mini-child lung function and biomarkers - program A–gene environment interactions. Subbarao P. AllerGen NCE Inc. ($215,000 2007-2009).

154 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

VX06-770-101: A phase 2a, randomized, double-blind,

The cognitive-behavioural model for teaching

Treatment of aspergillus fumigatus in patients with

communication skills: a pilot project. Solomon M.

cystic fibrosis: a randomized, double-blind, placebo-

placebo controlled study of VX770 in patients with

Educational Development Fund, University of Toronto

controlled trail. Ratjen F, Aaron S. Canadian Cystic

cystic fibrosis having g551d mutations to evaluate

($5,000 2007-2008)

Fibrosis Foundation ($220,800 2007-2010)

safety, phamacokinetics and biomarkers of CFTR activity. Accurso F, Durie P, Ratjen F, Tullis E. Vertex Pharmaceuticals, Inc. (US$30,000 2007-2008)

The Hospital for Sick Children Centre for the Study

Treatment of aspergillus fumigatus in patients with

of Complex Childhood Diseases (CSCCD). Post M.

cystic fibrosis: A randomized, double-blind, placebo-

Canadian Foundation for Innovation ($20,571,919

controlled trail. Ratjen F, Aaron S. Physicians’

Young infants with acute recurrent wheezing: to puff

206-2011)

Services Incorporated Foundation ($122,000

or not to puff? A randomized controlled trial.

2007-2009)

Grasemann H, Schuh S, Coates A, Willan A, Ungar W,

Training program in clinical nutrition. Pencharz P,

Dick P. SickKids Foundation/Institute of Human

Anderson H, Coates A, Darling P, O’Connor D, Archer

Development, Child and Youth Health/Canadian

M, Wolever T. Canadian Institutes of Health

Institutes of Health Research ($130,000 2008-2010)

($1,590,000 2002-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 155

Bonnie Cameron DivisionDr.of

DIVISION HEAD Dr. Brian Feldman FULL-TIME Dr. Susanne Benseler Dr. Ronald Laxer

Dr. Rayfel Schneider Dr. Shirley Tse Dr. Rae Yeung

MAJOR PART-TIME Dr. Earl Silverman Dr. Lynn Spiegel

PART-TIME Dr. Bonnie Cameron CROSS-APPOINTEES Dr. Vivian Bykerk Dr. Hans-Michael Dosch Dr. Paul Fortin

CLINICAL FELLOWS Dr. Clare Hutchinson Dr. Linda Hiraki Dr. Roman Jurencak Dr. Sathish Kumar

Dr. Lily Lim Dr. Marcela Pizana-Serna Dr. Heinrike Schmeling Dr. Elizabeth Stringer

ADMINISTRATIVE STAFF Sandra Bergeron Shona Magee Roseanne Richard

Division of Rheumatology OVERVIEW

Singapore. Paediatric rheumatology graduates have

Blankier S: First place winner, University of Toronto

The Division of Rheumatology provides comprehensive

done extremely well in obtaining academic placements

Ogryzlo Research Day for his poster presentation, The

care for children with rheumatic diseases. The

across Canada and around the world and trainees

role of atorvastatin in modulating pathogenesis in an

ambulatory clinics have approximately 5,000 patient

have been productive in the research arena.

animal model of kawasaki disease, June 2008.

well as at Bloorview Kids Rehab and the outreach

Research foci include the development of trial design

Cameron B: Claus Wirsig Humanitarian Award

clinic in Sudbury. In addition to the general rheumatology

for the study of rare diseases, outcome, prognosis and

winner, 2008.

clinics, there are unique multidisciplinary subspecialty

treatment studies in juvenile arthritis, SLE, neonatal

clinics for children with dermatomyositis, morphea,

lupus, scleroderma, dermatomyositis and vasculitis.

Hutchison C: First prize winner, University

systemic JIA and systemic lupus erythematosus. New

Basic research focuses on the immunopathogenesis

of Toronto Ogryzlo Research Day for her podium

clinics for children with central nervous system

of Kawasaki disease using an animal model.

visits per year at The Hospital for Sick Children, as

presentation, Open label study for treatment of angiography-negative, biopsy-positive primary

vasculitis and juvenile spondyloarthropathy have been initiated. The division makes extensive use of the

In July 2007, Dr. Rayfel Schneider was promoted to

medical day care unit, where children receive joint

Associate Chair, Education, Department of Paediatrics

injections under anaesthesia, therapeutic infusions,

and continues to work part-time as a staff rheumatologist.

Hutchinson C: Winner, American College of

or undergo investigations which would otherwise

Dr. Brian Feldman was promoted to Head of the

Rheumatology Pediatric Rheumatology Fellow Award,

require inpatient admission. An increasing number of

Division of Rheumatology and Dr. Shirley Tse was

in recognition of outstanding abstract and research

children have benefited from treatment with biologic

appointed Director of the Rheumatology Residency

accomplishments. Keystone, CO, 2008.

agents on the medical day care unit.

Training Program.

The Division of Rheumatology has the largest

HONOURS AND AWARDS

Canadian Network for Improved Outcomes in Systemic

paediatric rheumatology fellowship training program

Ardelean D: ACR REF/Abbott Medical and

Lupus Erythematosus, 2008 (Declined).

in North America and is fully accredited by the Royal

Paediatric Resident Research Award, 2007 for

College of Physicians and Surgeons of Canada. This

her research on VEGFB expression in a mouse

Hiraki L: Clinician Scientist Training Program (CSTP),

academic year, our fellows originated from Canada,

model of Kawasaki disease.

SickKids, Toronto, 2008 (Declined)

Benseler S: Clinical Recognition Award, Division

Hiraki L: Frank Knox Memorial Fellowship to conduct

of Paediatric Emergency Medicine, The Hospital

postgraduate studies in clinical epidemiology at

for Sick Children, 2007.

Harvard University.

CNS vasculitis in children, 2008.

Hiraki L: CaNIOS Kirkland Scholarship Award,

the Czech Republic, Germany, India, Mexico and

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 157

Hiraki L: Second place winner, University

Schmeling H: Winner, German Society of Pediatric

PUBLICATIONS

of Toronto Ogryzlo Research Day for her poster

Rheumatology (GKJR) Research Award at the Annual

Abrahamyan L, Feldman BM, Johnson SR, Beyen J,

presentation, Predicting macrophage activation

Meeting in Neuss, Germany, for her project, Nailfold

Shah PS: Quality of randomized clinical trials in juvenile

syndrome (MAS) in paediatric systemic lupus

capillary density is strongly associated over time

idiopathic arthritis. Rheumatology 2008: 1: p 366.

erythematosus (pSLE) parents at diagnosis, 2008.

with muscle and skin disease activity in juvenile dermatomyositis (supervisor Dr. Brian Feldman), 2007.

Akikusa JD, Feldman BM, Gross GJ, Silverman ED,

Gladman Award for sustained and outstanding

Silverman E: Ontario Lupus Association

pulse methyprednisolone. Pediatrics 2007: 119(3):

contributions to the University of Toronto Division

HOPE Award, 2008.

pp e778-e782.

Schneider R: University of Toronto, 2007 Dafna

Schneider R: Sinus bradycardia after intravenous

of Rheumatology as Program Director, Paediatric Rheumatology Residency Training Program.

Silverman E: Department of Paediatrics,

Akikusa JD, Schneider R, Harvey EA, Hebert D,

Nominated by Rheumatology Trainees, 2007.

University of Toronto, The Hospital for Sick Children,

Thorner PS, Laxer RM, Silverman ED: Clinical features

Subspecialty Education Award for Excellence

and outcome of pediatric Wegener’s granulomatosis.

in Clinical Teaching, 2007-2008.

Arthritis and Rheumatism 2007: 57(5): pp 837-844.

pharmacogenetics of juvenile idiopathic arthritis and

Stringer E: Completing her masters in clinical

Avcin A, Singh-Grewal D, Silverman ED, Schneider R:

juvenile dermatomyositis–The influence of single-

epidemiology and has accepted a staff position

Severe digital ischemia in a child with Wegener’s

nucleotide polymorphisms in genes coding for

at Dalhousie University, IWK Health Centre

granulomatosis. Scandinavian Journal of

metabolism pathway enzymes on the efficacy and

in the Division of Paediatric Rheumatology, 2008.

Rheumatology 2007: 36(1): pp 78-80.

Yeung R: The Arthritis Society Investigator Award,

Avcin T, Benseler SM, Tyrrell PN, Cucnik S, Silverman

Schmeling H: Postgraduate Medical Education Research Award, the Chisholm Memorial Fellowship:

toxicity of methotrexate, 2008. Schmeling H: Selected to participate in the Clinical

2007-2012.

ED: A follow-up study of antiphospholipid antibodies

Immunology Society (CIS) School in Systemic

and associated neuropsychiatric manifestations in

Autoimmune Diseases, Boston, 2008.

137 children with systemic lupus erythematosus. Arthritis Care and Research 2008: 59(2): pp 206-213.

158 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Avcin T, Silverman ED: Review: antiphospholipid

Elbers J, Benseler SM: Central nervous system

Hiraki LT, Benseler SM, Tyrrell PN, Hebert D, Harvey E,

antibodies in pediatric systemic lupus erythematosus

vasculitis in children. Current Opinion in Rheumatology

Silverman ED: Clinical and laboratory characteristics

and the antiphospholipid syndrome. Lupus 2007:

2008: 20(1): pp 47-54.

and long-term outcome of pediatric systemic lupus erythematosus. Journal of Pediatrics 2008: 152(4):

16(8): pp 627-633.

pp 550-556.

Feldman BM, Aledort L, Bullinger M, Delaney FM, Benseler SM, Silverman ED: Neuropsychiatric

Doria AS, Funk S, Giangrande P, Lundin B, Manco-

involvement in pediatric systemic lupus

Johnson M, Miners A, Scriba PC, Sricvastava A,

Hiraki LT, Hamilton J, Silverman ED: Measuring

erythematosus. Lupus 2007: 16(8): pp 564-571.

Blanchette VS: The economics of haemophilia

permanent damage in pediatric systemic lupus

prophylaxis: governmental and insurer perspectives.

erythematosus. Lupus 2007: 16(8): pp 657-662.

Benseler SM, Silverman ED: systemic lupus

Haemophilia 2007: 13(6): pp 1-5. Huber AM, Dugan ED, Lachenbruch PA, Feldman BM,

erythematosus. Rheumatic Disease Clinics

Perez MD, Zemel LS, Lindsley CB, Rennebohm RM,

of North America 2007: 33(3): pp 471-498.

Feldman BM, Funk S, Lundin B, Doria AS, Ljung R, Blanchette V: Musculoskeletal measurement tools

Wallace CA, Passo MH, Reed AM, Bowyer SL, Ballinger

Boros C, Silverman ED, Spence D, Blaser S:

from the International Prophylaxis Study Group (IPSG).

SH, Miller FW, Rider LG, Juvenile Dermatomyositis

Hydrocephalus and macrocephaly: new manifestations

Haemophilia 2008: 14(Suppl): pp 162-169.

Disease Activity Collaborative Study Group: Preliminary

Gong G, Barrera M, Beyene J, Bhat S, Carcao M,

assessment tool in juvenile dermatomyositis.

Lord S, Narayanan U, Sung L, Young N, Feldman BM:

Arthritis and Rheumatism 2008: 59(2): pp 214-21.

validation and clinical meaning of the cutaneous

of neonatal lupus erythematosus. Arthritis and Rheumatism 2007: 57(2): pp 261-266. Brunner HI, Gladman DD, Ibanez D, Urowitz MD,

The gap study (GapS) interview - developing a process

Silverman ED: Difference in disease features

to determine the meaning and determinants of quality

Huber AM, Dugan EM, Lachenbruch PA, Feldman BM,

between childhood-onset and adult systemic lupus

of life in children with arthritis and rheumatic diseases.

Perez MD, Zemel LS: The cutaneous assessment tool:

erythematosus (SLE). Arthritis and Rheumatism

Clinical and Experimental Rheumatology 2007: 25(3):

development and reliability in juvenile idiopathic

2008: 58(2): pp 556-562.

pp 486-493.

inflammatory myopathy. Rheumatology 2007: 46(10): pp 1606-1611.

Compeyrot-Lacassagne S, Tyrrell PN, Atenafu E, Doria

Gong G, Young N, Dempster H, Porepa M, Feldman

AS, Stephens D, Gilday D, Silverman ED: Prevalence

BM: The quality of my life (QOML) questionnaire:

Huber AM, Tomlinson GA, Koren G, Feldman BM:

and etiology of low bone mineral density in juvenile

The minimal clinically important difference (MCID)

Amitriptyline to relieve pain in juvenile idiopthic

systemic lupus erythematosus. Arthritis and

for pediatric rheumatology. Journal of Rheumatology

arthritis: a pilot study using Bayesian meta-analysis

Rheumatism 2007: 56(6): pp 1966-1973.

2007: 34(3): pp 581-587.

of multiple N-of-1 clinical trials. Journal of Rheumatology 2007: 34(5): pp 1125-1132.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 159

Ota S, Cron RQ, Schanberg LE, O’Neil K, Mellins ED,

Jacob CO, Reiff A, Armstrong DL, Myones BL,

Compeyrot-Lacassagne S, Rosenberg AM, Babyn P,

Silverman ED, Klein-Gitelman M, McCurdy D, Wagner-

Laxer RM: Pamidronate in the treatment of chronic

Fuhlbrigge RC, Feldman BM: Research priorities in

Weiner L, Nocton JJ, Solomon A, Zidovetzki R:

non-infectious inflammatory lesions of the mandible

pediatric rheumatology: the Childhood Arthritis and

Identification of novel susceptibility genes in childhood-

in children. Journal of Rheumatology 2007: 34(7):

Rheumatology Research Alliance (CARRA) consensus.

onset systemic lupus erythematosus using a uniquely

pp 1585-1589.

Pediatric Rheumatology 2008: 6(1): p 5.

designed candidate gene pathway platform. Arthritis Manlhiot C, Liang C, Tran D, Bitrum A, Tyrrell PN,

Ruperto N, Lovell DJ, Cuttica R, Wilkinson N, Woo P,

Feldman BM: Assessment of an infectious disease

Espada G, Wouters C, Silverman ED, Balogh Z,

Johnson S, Feldman BM, Hawker G: Classification

history preceeding juvenile dermatomyositis symptom

Henrickson M, Apaz MT, Baildam E, Fasth A, Gerloni V,

criteria for systemic scolerosis subsets. Journal

onset. Rheumatology 2008: 47(4): pp 526-529.

and Rheumatism 2007: 56(12): pp 4164-4173.

Lahdenne P, Prieur AM, Ravelli A, Saurenmann RK, Gamir ML, Wulffraat N, Marodi L, Petty RE, Joos R,

of Rheumatology 2007: 34: pp 1855-1863. Manlhiot C, Tyrrell P, Liang L, Atkinson A, Lau W,

Zulian F, McCurdy D, Myones BL, Nagy K, Reuman P,

Johnson SR, Goek O-N, Singh-Grewal D, Vlad SC,

Feldman BM: Safety of intravenous immunoglobulin

Szer I, Travers S, Beutler A, Keenan G, Clark J,

Feldman BM, Felson DT: Classification criteria in

in the treatment of juvenile dermatomyositis: adverse

Visvanathan S, Fasanmade A, Raychaudhuri A,

rheumatic diseases: a review of methodologic

reactions are associated with immunoglobulin A

Mendelsohn A, Martini A, Giannini EH, for the PRINTO

properties. Arthritis and Rheumatism 2007: 57 7):

content. Pediatrics 2008: 121(3): pp e626-30.

and PRCSG: A randomized, placebo-controlled trial of

Nicholson A, Berger K, Bohn R, Carcao M, Fischer K,

polyarticular course juvenile rheumatoid arthritis.

Lau A, Duong TT, Ito S, Yeung RSM: Matrix

Gringeri A, Hoots K, Mantovani L, Schramm W, Van

Arthritis and Rheumatism 2007: 56(9): pp 3096-3106.

Metalloproteinase-9 activity leads to elastin

Hout BA, Willan AR, Feldman BM: Recommendations

breakdown in an animal model of Kawasaki disease.

for reporting economic evaluations of haemophilia

Saurenmann R, Rose JB, Tyrrell PN, Feldman B, Laxer

prophylaxis: a normal group’s consensus statement

RM, Schneider R, Silverman ED: Epidemiology of

infliximab plus methotrexate for the treatment of

pp 1119-1133.

Arthritis and Rheumatism 2008: 58: 3: 854-63.

on behalf of the Economics Expert Working Group

juvenile idiopathic arthritis in a multi-ethnic cohort:

Lau A, Rosenberg H, Duong TT, McCrindle BW, Yeung

of the International Prophylaxis Study Group.

ethnicity as a risk factor. Arthritis and Rheumatism

RSM: Elastolytic matrix metalloproteinases and

Haemophilia 2007: 14: pp 127-132.

2007: 56(6): pp 1974-1984.

coronary outcome in children with Kawasaki disease. Pediatric Research 2007: 61(6): pp 710-715.

160 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Singh-Grewal D, Schneiderman-Walker J, Wright V,

Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,

BOOKS AND BOOK CHAPTERS

Bar-Or O, Beyene J, Selvadurai H, Cameron B, Laxer

Ota S, Feldman BM: Serial controlled N-of-1 trials of

Benseler SM: Kawasaki disease. In: Handbook of

RM, Schneider R, Silverman ED, Spiegel L, Tse S,

topical vitamin E as prophylaxis for chemotherapy-

Pediatric Emergency Medicine (Lalani A, Schneeweiss

LeBlanc C, Wong J, Stephens S, Feldman BM: Physical

induced oral mucositis in paediatric patients. European

S, eds.). Jones and Bartlett, Sudbury, MA, 2007.

exercise and activity in kids (PEAK): a randomized

Journal of Cancer 2007: 43(8): pp 1269-1275.

controlled single blinded trial of the effects of vigorous

Benseler SM: Koerperlische untersuchung. In:

exercise training on physical function in children with

Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P,

Paediatrische Rheumatologie (Wagner N, Dannecker

arthritis. Arthritis and Rheumatism 2007: 57(7):

Ota S, Feldman BM: Validation of the oral mucositis

GE Hrsg, eds.). Springer Medizin Verlag, Auflage, 2007.

pp 1202-1210.

assessment scale in pediatric cancer. Pediatric Blood and Cancer 2007: 49(2): pp 149-153.

Benseler SM: Rheumatologic emergencies. In:

Tyrrell P, Beyene J, Benseler S, Sarkissian T, Silverman

Schneeweiss S, eds.). Jones and Bartlett, 2007.

Stephens S, Singh-Grewal D, Bar-Or O, Beyene J, Cameron B, LeBlanc C, Schneider R, Schneiderman-

Handbook of Pediatric Emergency Medicine (Lalani A,

Walker J, Selvadurai H, Silverman E, Spiegel L, Tse S,

ED: Predictors of lipid abnormalities in children with

Wright V, Feldman BM: The reliability of exercise

new onset systemic lupus erythmatosus. Journal

Benseler SM: Seltene formen der vaskulitis. In:

testing and functional activity questionnaires in

of Rheumatology 2007: 34(10): pp 2112-2118.

Paediatrische Rheumatologie (Wagner N, Dannecker

children with juvenile arthritis. Arthritis and Rheumatism 2007: 57(8): pp 1446-1452.

GE Hrsg, eds.). Springer Medizin Verlag, Auflage, 2007. Uziel Y, Feldman BM, Krafchik BR, Laxer RM, Yeung RSM: Increased serum levels of TGF>1 in children

Benseler SM, Kuemmerle-Deschner J: Tagayashu

Stinson J, Toomey P, Stevens B, Kagan S, Duffy C,

with localized scleroderma. Pediatric Rheumatology

arteritis. In: Paediatrische Rheumatologie ((Wagner N,

Huber A, Malleson P, McGrath P, Yeung RSM, Feldman,

2007: 5: p 22.

Dannecker GE Hrsg, eds.). Springer Medizin Verlag,

B: Asking the experts: exploring the self-management

Auflage, 2007.

needs of adolescents with arthritis. Arthritis Care

Yeung RSM: Lessons learned from an animal model

and Research 2008: 59: pp 65-72.

of Kawasaki disease. Clinical and Experimental

Feldman BM, Ravelli A: Maintaining flexibility: joints

Rheumatology 2007: 25: (1 Suppl 44): pp S69-S71.

and other considerations. In: Myositis & You: A Guide

Stringer E, Yeung RSM: Pathogenesis of Kawasaki

to Juvenile Dermatomyositis for Patients, Families and

disease: rhe central role of TNFλ. Future

Yeung RSM: Clinical phenotype and coronary outcome

Health-care Providers (Rider L, Pachman L, Miller F,

Rheumatology 2008: 3: pp 69-77.

in Kawasaki disease. The Lancet 2007: 369: pp 85-88.

Bollar H, eds.). The Myositis Association, Washington, DC, 2007.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 161

Laxer RM: Rheumatic Disease Clinic of North America,

Determinants of risks and outcomes in inflammatory

Feasibility and impact of qigong as compared to

Volume 33, Issue 3, Pediatric Rheumatology. Elsevier

arthritis. Siminovitch K, Yeung RSM, Bernatsky S,

aerobic exercise in the treatment of childhood chronic

Saunders Co., Philadelphia, 2007.

Bombardier C, Boillais L, MacPherson A, Oen K.

musculoskeletal pain: a pilot randomized controlled

Canadian Institutes of Health Research

trial. Tse SML, Feldman BM, Fairbairn J, O’Brien C,

Schneider R, Laxer RM: Systemic juvenile idiopathic

($2,000,000 2007-2012)

Bar-Or O, Schneiderman-Walker J, Singh-Grewal D, Stephens S, Stinson J, Tyrell P, Whitney K, Wright V,

arthritis. In: Handbook of Systemic Autoimmune Diseases (Cimaz R, Lehman T, eds.). Elsevier,

Development and usability and feasibility testing of a

Cameron B, Lefebvre A, Laxer R, Schneider R,

Oxford, UK, 2008.

web-based self-management program for adolescents

Silverman ED, Spiegel L, Wu H, Bustamante K.

with arthritis. McGrath PJ, Stinson J, Hodnett E,

SickKids Foundation Complementary and Alternative

Woo P, Laxer RM, Sherry DD. Pediatric Rheumatology

Feldman B, Duffy C, Huber A, Tucker L, Hetherington

Health Care and Paediatrics Research Grant

in Clinical Practice. Springer-Verlag, London, 2007.

R, Yeung R. Canadian Arthritis Network ($445,500

($128,223 2005-2007)

2007-2009)

FUNDING

Feasibility of an interactive web-based rheumatology

Biologically-based outcome predictors in juvenile

Development and usability and feasibility testing of a

teaching module for paediatric residents. Tse SM,

idiopathic arthritis. Rosenberg A, Baxter-Jones AD,

web-based self-management program for adolecents

co-investigators: Feldman BM, Schneider R, Hyman A,

Gordon J, Muhajarine N, Oen K, Pahwa P, Scherer S,

with arthritis. Feldman B. Canadian Institutes of

research team: Stringer E, Bassilious E, Batthish M,

Turvey S, von Baever C, Whiting SJ, Yeung RSM,

Health Research ($69,350 2007-2009)

Bendiak G, Gupta S, Bradley N, Cameron T, Tait G, Shouldice M. Educational Dean’s Funds matched with

Bernatsky S, Duffy C, Silverman ED. Canadian Institutes of Health Research/Canadian Arthritis

Development of a feasible tool to measure oral

Network ($1,500,000 2006-2011)

mucositis in children with cancer. Sung L, Judd P,

Department of Paediatrics Funds ($18,300 2007-2008)

Tomlinson D, Doyle J, Hendershot E, Maloney AM,

Inflammation and atherosclerosis in paediatric

Childhood Arthritis and Rheumatology Research

Feldman B. Pediatric Oncology Group of Ontario

rheumatic diesase. Bradley T, Beyene J, Schneider R,

Alliance. Sandborg C, Brewer E, Feldman B, Hirsch R,

($13,334 2007-2008)

Feldman B, Silverman ED. Heart and Stroke

Ilowite N, Jung L, Lovel D, Malleson P, Mellins E,

Foundation of Ontario ($125,488 2007-2009)

O’Neil K, Schanberg L, Wallace C. Arthritis Foundation ($525,000 2004-2007)

International study: the efficacy of monoclonal anti-TNF antibody in JRA. Extension phase. Silverman ED (Site PI). Centocor Corporation ($110,000 2004-2010)

162 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

The role of chronic inflammation and systemic

Kawasaki disease: on our way to unravelling the

Pilot study of once-a-day prophylaxis for youth and

pathogenesis. Yeung RSM. Canadian Institutes

young adults with severe haemophila. Feldman BM,

lupus erythematosus-related factors in the

of Health Research ($318,873 2005-2008)

Rivard G, Carcao M, St-Louis J, Teitel J, Pulleneyegum E,

development of premature atherosclerosis in

Blanchette V. Bayer Partnership Fund ($250,000

paediatric SLE. Silverman ED, Bargman J,

New onset juvenile idiopathic arthritis: a Canadian

2007-2008)

Bradley T, Beyene J. The Heart and Stroke Foundation of Canada ($275,000 2006-2009)

multicentre collaborative outcome study. Yeung RSM, Duffy C, Oen K, Tucker L, Feldman B, Feldman D,

Research to improve outcomes for inflammatory

Young N, Spiegel L. Canadian Institutes of Health

arthritis. Inman R, Gladman D, Maksymowych W,

Towards a better understanding of Kawasaki disease.

Research ($998,000 2004-2009)

Rahman P (co-principal investigators), Davis A, Tsui F,

Yeung RSM. The Heart and Stroke Foundation of

Greenwood C, Badley E, Scherer S, Reeve J, Cook R

Canada ($160,565 2006-2008)

Novel biomarkers in inflammatory arthrits. Siminovitch K,

(project co-investigators), Boonen A, Choquette D,

Bernatsky S, Bombardier C, Boillais L, Yeung RS.

Colbert R, Frank J, Ghahary A, Gignac M, Husted J,

Canadian Arthritis Network ($150,000 2007-2009)

Keen K, Lambert R, Laxer R, Marra C, Mosher D,

heart block. Hamilton RH, Gross G, Silverman ED.

Mulholland K, Nair B, Poole R, Richards C, Salanen D,

Canadian Institutes of Health Research ($197,000

Pain in child health (PICH): an innovative,

Shojania K, Thomson G, Tse S. The Arthritis Society,

2006-2009)

transdisciplinary, cross-Canada, research training

National Research Initiative ($2,500,000 2005-2010)

Towards understanding the mechanism of congenital

Validation of accelerometry as a measure of physical

consortium. McGrath P, Craig K, von Baeyer C, Stevens B, Johnston C, Finley A (co-principal

Rituximab therapy in refractory adult and juvenile IIM.

activity and inactivity in children with chronic disease.

investigators), Schellinck H, Unruh A, Kenny N,

Oddis CV, Reed AM, Pestronk A, Rider L, Miller F,

Feldman B, Stephens S, Takken T, Wright V, Tramblay

Camfield C, Harmon K, Frager G, Rathwell T, Howlett A,

Eisenberg R, Feldman BM, Ytterberg S, Levine T.

M, Beyenne J, Biggar W, Esliger D, Longmuir P,

Otley T, Connolly J, Feldman BM, Langer J, Taddio A,

National Institutes of Health ($7,732,309 2004-2009)

McCrindle B, Schneiderman-Walker J, Van Der Net J.

Hetherington R, Grunau R, Oberlander T, Chambers C,

Superantigens in autoimmunity. Yeung RSM. Canadian

2007-2008)

Dube L, Ohlsson A, Murray M, Barr R, Koren G

Institutes of Health Research ($172,553 2006-2008)

Canadian Institutes of Health Research ($64,985

Baruchel S, Brown S, Gibbins S, Salter M,

(co-investigators). Canadian Institutes of Health Training Grant ($300,000 2002-2008)

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 163

Dr. Golda Milo-Manson

VICE PRESIDENT, MEDICINE & ACADEMIC AFFAIRS Dr. Golda Milo-Manson

PHYSICIAN DIRECTORS Dr. Peter Rumney, Rehabilitation & Complex Continuing Care Dr. Darcy Fehlings, Child Development Program Dr. Rob Carmichael, Chief of Dental Services

STAFF PHYSICIANS Dr. Doug Biggar Dr. Elizabeth Jimenez Dr. Tamarah Kagan-Kushnir Dr. Anne Kawamura Dr. Jeffrey Kobayashi

164 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Dr. Dr. Dr. Dr. Dr.

Laura McAdam Gilbert Miller Angela Orsino Jonathan Tolkin Wendy Roberts

Bloorview Kids Rehab OVERVIEW

MEDICAL EDUCATION

Developmental Paediatric Residency Program Director

As a provincial facility, we see almost 7,000 children

Year 2007

Dr. Golda Milo-Manson

and youth on an outpatient basis and we have over

Paediatric RII...................................... 380 days

650 patient admissions each year.

Neurology........................................... 80 days

Resident Coordinator

Psychiatry .......................................... 30 days

Dr. Anne Kawamura

Bloorview Kids Rehab offers both inpatient and

PM&R ................................................ 60 days

outpatient developmental and rehabilitation services

Medical students................................ 300 days

Academic Accomplishments

to the children and families of greater Toronto and

Developmental paediatric

see Division of Developmental Paediatrics Report.

provides tertiary services in pediatric rehabilitation to

subspecialty residents ........................ 980 days

the Province of Ontario. TOTAL ................................................ 1830 days

HIGHLIGHTS • April 2008 Royal College accreditation – full approval • Third Annual Roszel Developmental Paediatric Resident Research Day, February 2008 Resident Prize Winner: Dr. Kassia Johnson • Dr. Darcy Fehlings: Inaugural holder, Bloorview Children’s Hospital Foundation’s Chair in Developmental Paediatrics, 2007

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 165

Division of

Dr. David Grant

DIRECTOR Dr. David Grant TRANSPLANT PHYSICIANS Dr. Upton Allen Dr. Darius Bagli

Dr. Dr. Dr. Dr. Dr. Dr.

Mark Cattral John Coles Anne Dipchand Walid Farhat Annie Fecteau Hartmut Grasemann

Dr. Paul Greig Dr. Elizabeth Harvey Dr. Diane Hebert Dr. Nicola Jones Dr. Paul Kantor Dr. Shaf Keshavjee

Dr. Dr. Dr. Dr. Dr. Dr.

Valerie Langlois Simon Ling Seema Mital Vicky Ng Marc de Perrot Andrew Pierre

Dr. Dr. Dr. Dr. Dr. Dr.

Lisa Robinson Pipi Salle Mindy Solomon Glen Van Arsdell Thomas Wadell Paul Wales

ADMINISTRATOR Wanda Schoonheyt ADMINISTRATIVE SUPPORT Christine Garner

Transplant Centre OVERVIEW

Our clinical programs were busy during the past year.

SickKids has one of the largest paediatric solid

A total of 56 organs were transplanted in 52 children

including the North American Paediatric Renal

organ transplant programs in North America, with

and our sphere of clinical activity expanded with the

Transplant Co-operative Study Group, the Paediatric

We contribute to international research groups,

well over 1,000 children in receipt of a solid organ

integration of the Group for the Improvement of

Heart Transplant Study Group, NIH-funded fulminate

graft. We deliver cutting-edge, family-centred patient

Intestinal Function and Treatment (GIFT) into the

liver failure study group, and the Paediatric Liver

care with clinical volumes that are within the top

Transplant Centre. To meet growing clinical needs

Transplantation Registry. Local research projects with

five-10 per cent of transplant centres in North America.

and ensure that our patients receive care on the

extramural funding include: vaccination strategies;

Patient survival rates match or exceed the best

appropriate unit, the hospital created surge capacity

prevention of Epstein-Barr virus and Respiratory

programs worldwide. Our clinical programs are

on 6B in 2008 and expanded our interdisciplinary

Syncytial virus complications post-transplantation

enhanced by interdisciplinary educational programs;

team to improve access to rehabilitation services,

(Upton Allen); quality of life following heart and liver

fellowship training in transplantation; and basic,

psychology and transplant pharmacy expertise.

transplantation (Anne Dipchand, Stacey Pollack,Vicky Ng); xenotransplantation (David Grant, Thomas

translational and clinical research. We were also busy academically. Members of the

Wadell); adolescent issues of transition to adult care

Formerly known as the Paediatric Academic Multi-

Transplant Centre served as advocates for paediatric

(Miriam Kaufman); techniques to enhance

Organ Transplant Program (PAMOT), we successful

solid organ transplantation at the provincial, national

lung recovery for transplantation (Shaf Keshavjee and

transitioned to become the SickKids Transplant

and international levels as members of the Board of

colleagues); and leukocyte trafficking in allograft

Centre in February 2008. A search for a new executive

the International Paediatric Lung Transplant

rejection (Lisa Robinson). Our trainees continued to

team was completed in June 2008 with the

Committee (Mindy Solomon); International Paediatric

reflect the international appeal of our fellowship

appointment of David Grant as Director; Anne

Transplant Association (Anne Dipchand); Trillium Gift

program with Dr. Meeta Malik (Chief Fellow 2007-08)

Dipchand, Associate Clinical Director; Freda Miller,

of Life (Diane Hebert); and as president of the

becoming an international ambassador for SickKids

Associate Research Director; and Wanda Schoonheyt,

International Intestine Transplant Society (David

as she assumed her faculty position in the UK.

Director, Clinical Programs.

Grant). Our basic and clinical research activities continued to focus on optimizing long-term transplant

In 2008-09, the new Transplant Centre will focus

outcomes in children.

on fundraising, improving our educational offering building stronger links with families and referring doctors and enhancing our research programs.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 167

2007-08 Housestaff

Paediatric Housestaff CHIEF RESIDENTS - PGY4S Dr. Nirit Bernhard Dr. Sharon Naymark

ASSOCIATE CHIEF RESIDENTS - PGY4S Dr. Karoon Danayan Dr. Elizabeth Gold Dr. Krishanthi Gunawardena Dr. Mary Kiaira

THIRD-YEAR RESIDENTS PGY3S Dr. Dalia Al-Abdulrazzaq Dr. Fatoumah Al-Abdulrazzaq Dr. Amal Al-Maani Dr. Sowmya Balasubramanian Dr. Ereny Bassilious Dr. Michelle Batthish Dr. Glenda Bendiak Dr. Nicholas Blanchette Dr. Michelle Bridge Dr. Karoon Danayan Dr. Sumit Gupta Dr. Joelene Huber Dr. Sangeet Kathuria Dr. Tarek Khalefih Dr. Melanie Makhija Dr. Shruti Mehrotra Dr. Briseida Mema Dr. Caroline McLaughlin Dr. Michelle Porepa Dr. Ewurabena Simpson Dr. Andrea Wan Dr. Kevin Weingarten Dr. Eitan Weinberg

SECOND-YEAR RESIDENTS PGY2S Dr. Dr. Fahed Aljaser Dr. Ahmed Alterkait Dr. Kesete Bezu Dr. Joyce Ching) Dr. Avram Denburg Dr. Alisha Kassam Dr. Rae Koffman Dr. Dianne Lim Dr. Nadia Luca Dr. Arif Manji Dr. Gagandeep Saund Dr. Deena Savlov Dr. Ksenia Slywynska Dr. Gordon Soon Dr. Christopher Sulowski Dr. Mark Tessaro Dr. Nisha Thampi Dr. Alène Toulany

FIRST-YEAR RESIDENTS PGY1S Dr. Leila Fazeli Chaghoshi Dr. Amy French Dr. Silvio Gonzalez Dr. Andrea Hoffman Dr. Emilie Jean-St-Michel Dr. Julie Johnstone Dr. Dina Kulik Dr. Ana Marissa LagmanBartolome Dr. Paola Luca Dr. Mary Kate Mennie Dr. Niraj Mistry Dr. Reem Mohammed Dr. Nikhil Pai Dr. Anastasios (Taso) Papadopoulos Dr. Cynthia Popalis Dr. Alisha Rachlis Dr. Audrey Segal Dr. Maher Shalabi Dr. Shawna Silver Dr. Jennifer Smith Dr. Anita Villani Dr. Cyrus Boelman (PGY1 neuro) Dr. John Brandsma (PGY1 neuro)

PRACTICE READY ASSESSMENT (PRA) Dr. Mariana Boragina

Paediatric Grand Rounds 2007

August 22 – Michaela Cada, Tony Truong, Division

October 3 – Dr. Michael Geraghty, Head, Department

July 4 – Zia Bismilla, Adam Rapoport, Barry Seltz,

of Haematology/Oncology: Childhood cancer survivors

of Genetics and Metabolism, Children’s Hospital of

Division of Paediatric Medicine: Academic general

and late effects: paying the price for cure

Eastern Ontario: Expanded newborn screening in Ontario

paediatric research: changing the way we practice July 11 – Fotini Kavadas, Elana Lavine, Division

August 29 – April Kam, Chris Ricks, Division

October 10 – Dr. David Goodman, Centre for Health-

of Paediatric Emergency Medicine: Foul play

care Research and Reform, the Dartmouth Institute for

September 5 – Dr. Fraser Mustard, Head, Founder’s

Harry Bain PSI Lecture: Are more paediatricians linked

Network, Companion of the Order of Canada, Laureate

to better health outcomes for children?”

of Immunology/Allergy: Changes in ancient places: new directions in immunodeficiency

Health Policy and Clinical Practice, New Hampshire:

July 18 – Rachel Spitzer, Divison of Endocrinology -

of the Canadian Medical Hall of Fame: Robert Haslam

Adolescent Gynaecology: Meeting contraceptive challenges:

Lecture: early child development and trajectories

October 17 – Dr. Fiona Campbell, Anaesthesia,

contraception for the medically complex adolescent

in physical and mental health

SickKids: Pain matters

July 25 – Linda Hiraki, Heinrike Schmeling,

September 12 – Dr. Phil Sherman, SickKids,

October 24 – Dr. Joseph Flynn, Nephrology,

Sathish Kumar, Division of Rheumatology:

Division of Gastroenterology, Hepatology and

Children’s Hospital of Montefiore: Ambulatory

Childhood chronic arthritis: can we do better?

Nutrition: Probiotics and gastrointestinal health:

blood pressure monitoring in children and

ready for prime time?

adolescents: where are we in 2007?

August 1 – Reshma Amin, Division of Respiratory Medicine: Cystic Fibrosis: from salt licks to heel pricks

September 19 – Dr. Friedhelm Hildebrandt, Professor

October 31 – Dr. Russell Ware, Chair, Department

of Pediatrics and Human Genetics, Frederick Huetwell

of Haematology, St. Jude Children’s Research Hospital,

Professor for the Cure and Prevention of Birth Defects

Memphis Bernard Laski Lecture: The rational use of

Division of Gastroenterology, Hepatology and Nutrition:

University of Michigan, Ann Arbor: Genetics of inherited

hydroxyurea in sickle cell disease

Is my baby yellow or is it the new compact fluorescent

renal disease

August 8 – Catharine Walsh and Eric Benchimol,

November 7 – Dr. Norman Fost, Director, Program

light bulb? An approach to the jaundiced infant September 26 – Michael Weinstein, David Chiasson,

in Bioethics, Vice-Chair, Department of Medical

August 15 – Jonathon Costello, Hadi Mohseni-Bod

Greg Wilson, SickKids: Clinical Pathology Conference:

History and Bioethics, University of Wisconsin Hospital:

(Aphrothite Kotsakis), Critical Care Response Team:

case review: a case of a child with fever

Bioethics Lecture: Parental requests for ‘futile’ treatment

Critical Care Response Team (CCRT) at The Hospital for Sick Children: evidence and practice

170 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

November 14 – Dr. Richard Aplenc, Pediatric

2008

February 20 – Dr. Noni MacDonald, former Dean of

Oncology/Stem Cell Transplant Program, Children’s

January 9 – Dr. Robert Hamilton, Division of

Medicine, Dalhousie University, Halifax, Nova Scotia:

Hospital of Philadelphia: Daniel Burton Lecture:

Cardiology, SickKids: Clinical and research cardiac

Sexually-transmitted infections and youth: reality bites

Studies of genetic variation and paediatric leukaemia:

genetics in high-risk hereditary heart conditions February 27 – Dr. Amitai Ziv, Director, Israel Center

if you mix ice cream with cow manure, it won’t hurt the

for Medical Simulation, Deputy Director, Chaim Sheba

cow manure

January 16 – Dr. David Fisman, Child Health Evaluative Sciences, SickKids Making best bets: how modelling

Medical Center, Israel: Medical Education Day: Medical

November 21 – Dr. Sylvain Chemtob, Pediatrics,

can inform vaccine policy

simulation changing the face of medical education

Hôpital Ste. Justine, Université de Montréal: Barry Smith Lecture: Insights into retinopathy of prematurity: injury invites repair

in the 21st century January 23 – Dr. Ben Alman, Head of Orthopaedic Surgery, SickKids: From fibromatosis to fractures:

March 5 – Dr. Walter Kahr, Division of Haematology/

new therapies based on modulating beta-catenin

Oncology, SickKids: New insights in cell biology

November 28 – Dr. Sheldon Kaplan, Chief of Infectious

from studies of inherited platelet disorders

Disease, Texas Children’s Hospital: Community-

January 30 – Dr. Charles Scriver, Alva Professor

acquired methicillin resistant Staphylococcus

Emeritus of Human Genetics, McGill University,

aureus infections - they are everywhere December 5 – Dr. Bruce Gelb, Arthur J and Nellie Z

March 19 – Dr. Robert Sundel, Rheumatology,

Montreal Children’s Hospital Research Institute:

Harvard University, Boston: Kawasaki disease

Jacob’s Ladder Lecture: The journey but not the

at 40 years old

arrival yet. A model for ‘personalized medicine’?

Cohen Professor of Pediatrics and Genetics and

March 26 – Dr. Paul Kurtin, Vice-President and Chief

Genomic Sciences, Mount Sinai Hospital, New York:

February 6 – Dr. Jeffrey Whitsett, Chief of

Quality and Safety Officer, Center for Child Health

Noonan Syndrome and related disorders: RAS

Neonatology, Perinatal & Pulmonary Biology,

Outcomes, Children’s Hospital, San Diego: Improving

Cincinnati Children’s Hospital: Genetic basis

care for the children of Ontario

signalling – getting it just right

of normal adaptation to air breathing December 12 – Dr. Carole Marcus, Pediatric

April 2 – Dr. Andrew Redington, Head, Division of

Pulmonary Medicine, Joseph Stokes Jr. Research

February 13 – Dr. Anne Matlow, Director, Infection

Institute, Children’s Hospital of Pennsylvania:

Prevention and Control Program and Medical

Cardiology, SickKids: Remote ischemic preconditioning: harnessing an innate mechanism of cellular protection

Childhood obstructive sleep apnea – implications

Director, Patient Safety, SickKids Can we do

against ischemic injury in adults and children

for future health

more to help achieve closure through disclosure?

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 171

April 9 – Dr. Michael Cabana, Director, Division

April 30 – Paediatric Update, Dr. Harriet MacMillan,

May 21 – Dr. David Hackam, Roberta Simmons

of General Pediatrics,Professor of Pediatrics,

McMaster University (Host: Dr. Suzan Schneeweiss):

Associate Professor of Pediatric Surgery, Cell Biology

Epidemiology and Biostatistics, UCSF: Physician

Paediatric Update: An overview of family violence:

and Physiology, University of Pittsburgh School of

asthma care education: results of the PACE study

implications for child development and approaches

Medicine, Department of Pediatric General and

to prevention

Thoracic Surgery, Children’s Hospital of Pittsburgh

April 16 – Dr. Kevin Chan, Division of Paediatric

of UPMC A novel role for the innate immune system

Emergency Medicine: Global child health research,

May 7 – Dr. Vivien Burt, Professor of Psychiatry,

in the pathogenesis and treatment of neonatal

from Harvard to Toronto

David Geffen School of Medicine, UCLA: Motherisk

necrotizing enterocolitis

Lecture: Mood disorders in women: focus on reproductive transitions

May 28 – ANNUAL RESEARCH DAY

building humanitarian projects

May 14 – Dr. Lisa Shaffer, CEO and Technical Director,

June 4 – Professor Linda DeMeirleir, Head of Pediatric

Signature Genomic Laboratories, Spokane, WA: The

Neurology, University of Belgium, Brussels Barsky

Dr. Robert Hilliard, Division of Paediatric Medicine:

use of array CGH in dDiagnosis and syndrome discovery

Lecture: The clinical spectrum of mitochondrial

Dr. Dennis Scolnik, Division of Paediatric Emergency Medicine: Starting small and

diseases in young children and approach to diagnosis

The changing scene of medical education in Africa Global Child Health Lecture: What SickKids is,

May 21 – Dr. Suzanne Kamel-Reid, Senior Scientist,

could and should be doing?

Division of Applied Molecular Oncology, Ontario

June 11 – Dr. Anne Matlow, Director, Infection

Cancer Institute (OCI) Princess Margaret Hospital,

Prevention and Control Program and Medical Director,

April 23 – Dr. Jay Rosenfield, Vice-Dean,

University Health Network: Andrew Sass-Kortsak

Patient Safety, SickKids: Patient Safety Symposium

Undergraduate Medical Education, University

Memorial Lecture: Insights into the biology of acute

of Toronto: The future of (undergraduate) medical

promyelocytic leukaemia: the role of variant fusion proteins

education in Canada

172 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

June 18 – ANNUAL AWARDS DAY

Promotions/Recognition PROMOTED TO PROFESSOR OF PAEDIATRICS Dr. Debra Katzman

THOSE WHO REACHED NORMAL RETIREMENT AGE The following reached normal

PROMOTED TO ASSOCIATE PROFESSOR OF PAEDIATRICS

retirement age in June of 2008:

Dr. Manuel Carcao

Dr. Milton Gold

Dr. Jill Hamilton

Dr. Andrew Shennan

Dr. Hartley Garfield

Dr. Meredith Irwin Dr. Kyong-Jin Lee

25 YEARS OF SERVICE AWARDS

Dr. Golda Milo-Manson

The following were honoured for their

Dr. Hiroshi Otsubo

25 years of service to The Hospital

Dr. Jose Luis Perez Velasquez

for Sick Children in June of 2008:

Dr. Jonathan Pirie

Dr. Carlos Contreras

Dr. Elena Pope

Dr. Hyder Fazal

Dr. Lisa Robinson

Dr. Dennis Gurwitz

Dr. Shelly Weiss

Dr. Peggy Kirkpatrick Dr. Ken Schelberg

Awards TEACHING/EDUCATION AWARDS

Dr. Brian Chisamore – Postgraduate Community

Dr. Leah Harrington – RHA Haslam Pre-Clerkship

Teaching Award in recognition of excellence in the

CLINICAL AWARDS Dr. Victor Blanchette – Richard Rowe Award for

Teaching Award to the faculty member who has

teaching of paediatric residents within community-

Clinical Excellence in Paediatric Medical Care to the

demonstrated excellence in pre-clerkshop teaching.

based hospitals and offices.

physician in the Department of Paediatrics who has demonstrated excellence in the delivery of clinical care

Dr. Raymond Shu – The Lionel Weinstein Clerkship

Dr. Shazhan Amed – PERLS (Paediatric Educational

in the broadest sense over a significant period of time.

Teaching Award to the faculty member who has

Resident Lecture Series) Award to the faculty member

demonstrated excellence in clerkship teaching.

who has demonstrated commitment to excellence in

Dr. Angelo Mikrogianakis – Junior Faculty Award for

teaching at the paediatric academic sessions.

Clinical Excellence in Paediatric Medical Care to a

Teaching Award in recognition of excellence in

Dr. Earl Silverman – Subspecialty Teaching Award

appointment to an academic health sciences centre,

the teaching of medical students within community-

to the faculty member who has demonstrated

who has demonstrated excellence in the delivery of

commitment to excellence in teaching the

clinical care.

Dr. Eddy Lau – The Undergraduate Community

based hospitals and offices.

physican within the first five to 10 years of

subspecialty residents and clinical fellows.

RESEARCH AWARDS

Dr. Eyal Cohen – Harry Bain Award to a full-time member of the Department of Paediatrics who

Dr. Jonathan Pirie – Continuing Medical Education

Dr. Lillian Sung – Junior Physician Researcher Award

has demonstrated excellence in teaching as

Award to the faculty member in recognition of

to recognize outstanding achievements and progress

nominated by core paediatric residents.

excellence in course co-ordination in an event

within the first six years after initial appointment as a

sponsored by the Department of Paediatrics/

faculty member at an academic health sciences centre.

Dr. Sheila Jacobson – Marvin Gerstein Award to a

University of Toronto and/or long-term contribution to

part-time member of the Department of Paediatrics

Continuing Education in the Department of Paediatrics.

PAEDIATRIC ADMINISTRATIVE AWARD

who has demonstrated excellence in teaching as

Annabel Sousa – In recognition of an administrative

nominated by core paediatric residents.

support staff member in the Department of Paediatrics who has demonstrated outstanding performance and excellence in all aspects of their role. This individual possesses outstanding communication and interpersonal skills and is motivated to perform above and beyond their daily responsibilities. This award was first awarded in 2007.

174 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Resident and Fellow Awards and Achievements TEACHING/EDUCATION AWARDS

RESEARCH AWARDS

Dr. Briseida Mema, PGY3, Dr. Ewurabena Simpson,

Core Paediatrics

PGY3, Dr. Sharon Naymark, PGY4 – Christopher Ondaatje

1. Sumit Gupta

Award to a senior resident for excellence in clinical

2. Anita Villani

teaching as nominated by core paediatric residents.

SENIOR TRAINEE – CLINICAL SCIENCE CANMEDS AWARD – SUBSPECIALTY FELLOW Dr. Leonard Barry Selz

1. Ghassan Abu Kuwaik 2. Haydi Al Wassia Tie 3. Amy Lee Chong

CLINICAL AWARDS

Tie 3. Daria Grafodatskaya

Dr. Michelle Batthish – The Saunders Prize to a senior resident who has demonstrated

SENIOR TRAINEE – BASIC SCIENCE

excellence in clinical paediatrics.

Tie 1. Aleixo Muise Tie 1. Adam Shlien

176 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 177

Annual Resident and Fellow Research Day (May 28, 2008) ORAL PRESENTATIONS

Osman M, Respiratory Medicine

Al-Jasmi F, Clinical and Metabolic Genetics

Al-Harthy N, Paediatric Emergency Medicine

Asthma morbidity: is it peanuts? Osman M,

Computer-assisted teaching of mucopolysaccridosis

The crying infant: which tests to choose?

Foty R, To T, Atkinson A, Stieb D, Dell S

by patient management problems Al-Jasmi F,

Al-Harthy N, Freedman SB, Thull-Freedman J

Moldovan L, Clarke JTR Tole S, Nephrology

Alwassia H, Neonatology

SLIT-2 inhibits neutrophil chemotaxis. Tole S,

Neonatal outcomes in multiple gestations:

Huang YW, Rui M, Yan M, Liu GY, Robinson LA

does mode of conception have an impact? Alwassia H, Shah K, Shah P, Shah V

Aljunaibi A, Endocrinology Factors affecting postsurgical blood sugar levels in children and youth with Type 1 diabetes mellitus

Wine E, Gastroenterology, Hepatology and Nutrition

(T1D) undergoing anaesthesia/surgery. Aljunaibi A,

Osteopontin-null mice are protected from citrobacter

Stephens D, Daneman D

Appendino J, Neurology

rodentium-induced colonic hyperplasia due to a reduction

The impact of amplitude integrated

in attaching-effacing lesions. Wine E, Shen-Tu G, Ngan

AlKhater R, Neurology

electroencephalography on neonatal

B-Y, Licht C, Sodek J, Zohar R, Sherman PM

Toward the identification of paediatric movement

intensive care unit practice. Appendino JP, McNamara P, Keyzers M, Hahn C

disorders genes. A family with a novel neurological

POSTER PRESENTATIONS

disorder. AlKhater RA, Rilstone J, Minassian BA

Abosoudah I, Haematology/Oncology Bismilla Z, Paediatric Medicine

WT1 expression and hemihypertrophy in congenital

Al-Murshedi F, Clinical and Metabolic Genetics

Evaluation of neonatal endotracheal intubation

mesoblastic nephroma. Abosoudah I, Ngan B-Y,

Elevated propionylcarnitine on newborn screening

skill in a tertiary care NICU. Z Bismilla, E Finan,

Grant R, Weitzman S

and vitamin B12 levels. Al-Murshedi F, Al-Jasmi F,

Jefferies A, Whyte H, LeBlanc V

Crushell E, Feigenbaum A Abu Kuwaik G, Developmental Paediatrics

Gupta S, Core Paediatrics

Immunization uptake of siblings of children with

Al-Qadhi S, Paediatric Emergency Medicine

Incidence and predictors of treatment related

Autism. Abu Kuwaik G, Green PE, Roberts W,

A retrospective chart review of nail bed lacerations in

mortality in paediatric acute leukaemia in El Salvador.

Zwaigenbaum L, Bryson S, Brian J, Szatmari P, Smith I

children presenting to ER. Al-Qadhi S, Ratnapalan S

Gupta S, Bonilla M, Fuentes SL, Howard SC, Caniza M, Barr R, Greenberg ML, Ribeiro R, Sung L

Akiyama T, Neurology

Al-Rawas A, Haematology/Oncology

Movie of ictal high-frequency oscillations and intracranial

Treatment of primary brain sarcoma with Ifosphamide,

video EEG: marching high-frequency power correlating

Carboplatin, Etoposide (ICE) and focal radiation.

with symptoms in Jacksonian seizures. Akiyama T

Al-Rawas A, Bouffet E, Laperriere N, Bartels U

178 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Al-Saleh S, Respiratory Medicine

Barnett C, Clinical and Metabolic Genetics

Brandsema J, Neurology

Induced sputum compared with expectorated

Loeys-Dietz syndrome: in-vitro restoration of fibrillin

The incidence of asymptomatic cerebral arteriopathies

sputum to identify respiratory pathogens in children

and elastin production after treatment with losartan

in neurofibromatosis type 1: the need for MRI

with cystic fibrosis. Al-Saleh S, Grasemann H,

and dexamethasone. Barnett C, Hinek A, Bradley TJ,

screening. Brandsema J, Rea D, Parkin P, Armstrong D,

Dell S, Yau Y, Waters V, Martin S, Ratjen F

Chitayat D

Askalan R

Al-Shanteer S, Neonatology

Barton-Forbes M, Infectious Diseases

Bronte-Tinkew D, Gastroenterology,

Response times and severity of illness during the

Post-transplantation Lymphoproliferative Disorder

Hepatology and Nutrition

transport of neonates: is there a relationship?

(PTLD) in pediatric solid organ transplant recipients:

Helicobacter pylori caga activates the signal

Al-Shanteer S, Lee K-S, Tomlinson C, Whyte H

A review of Hospital for Sick Children (SickKids)

transducer and activator of transcription 3 (STAT3)

PTLD Registry: 2000-2007. Barton-Forbes M,

pathway in vitro and in vivo. Bronte-Tinkew DM,

Amin R, Respiratory Medicine

Melbourne T, Heurter H, Dipchand A, Hebert D, Ng V,

Terebiznik M, Franco A, Ahn D, Mimuro H,

Chronic infection with aspergillus fumigatus

Solomon M, Fecteau A, Grant D, Ngan B, Allen UD

Sasakawa C, Ropeleski MJ, Peek Jr. RM, Jones NL

exacerbations in cystic fibrosis patients.

Benchimol E, Gastroenterology, Hepatology and Nutrition

Cain J, Nephrology

Amin R, Corey M, Tullis E, Ratjen F

Toxic megacolon in children with inflammatory bowel

Lineage specific functions of sonic hedgehog

disease: Clinical and radiographic characteristics.

signalling during murine kidney development.

Baaboud A, Emergency Medicine

Benchimol EI, Turner D, Mann EH, Thomas KE,

Cain JE, Nieuwenhuis E, Hui C-C, Rosenblum RD

Timing of administration of antibiotic and

Gomes T, McLernon RA, Griffiths AM

is associated with higher rates of pulmonary

Chan D, Neurology

clinical outcome in febrile neutropenia with oncology disease. Baaboud A, Ratnapalan S

Boelman C, Neurology

The relationship between rapid oscillatory activity

Cerebrovascular disease in meningitis: Safety and

in premature and normal term neonatal EEG and

Baker J, Haematology/Oncology

efficacy of anticoagulation. Boelman C, Askalan R

the effect of phenobarbitone. Chan D, Yamazaki M,

Prognostic factors in advanced-stage paediatric

Akiyama T, Chu B, Donner E, Otsubo H

anaplastic large cell lymphoma (ALCL): analysis of

Boskovic R, Clinical Pharmacology and Toxicology

patients from two consecutive Pediatric Oncology

Long-term outcomes of children prenatally exposed

Crushell E, Clinical and Metabolic Genetics

Group of Ontario (POGO) studies. Baker JM,

to valproic acid and carbamazepine: meta-analysis.

The Lebers hereditary optic neuropathy mutation

Weitzman S, Breakey VR, Smith JN, Zagorski BM,

Boskovic R, Banach R, Einarson T, Moretty M, Koren G

T14484C can cause Leigh-like disease. Crushell E,

Hutchison RE, Laver JH

Robinson B, Blaser S, Murray S, Ainsworth PJ, Feigenbaum A.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 179

Crystal M, Cardiology

Fujimoto A, Neurology

Go C, Neurology

Coronary stents in children: a bridge to surgery.

Total intravenous anaesthesia for MEG sediation,

Effects of valproic acid withdrawal on seizures by

Crystal MA, Hickey EJ, Lee K-J, Chaturvedi RR,

part II. Fujimoto A, Ochi A, Sugiyama I, Akiyama T,

analysis of scalp and intracranial video EEG. Go C et al

Benson LN

Otsubo H, Snead III OC

Di Giovanni V, Nephrology

Gana J, Gastroenterology, Hepatology and Nutrition

The BMP receptor, ALK3, controls murine

Non-invasive diagnosis of esophageal varices

patients with duplication 17p11.2 syndrome.

nephrogenesis. Di Giovanni V, Rosenblum N

in children. Gana JC, Roberts E, Ng VL, Ling SC

Goh E, Goobie S, Yoon G, Shago M, Sgro M,

Goh E, Goobie S, Clinical and Metabolic Genetics Bilateral dysplastic kidneys as a feature in

Chitayat D, Mendoza-Londono R Durbin A, Haematology/Oncology

Garcia-Bournissen F,

A JNK dependent switch determines the

Clinical Pharmacology and Toxicology

Gonska T, Gastroenterology, Hepatology and Nutrition

oncogenic or tumour suppressive activity of ILK

Comparison of cocaine levels in hair of children

Development of a novel outcome parameter for

in rhabdomyosarcoma. Durbin AD, Somers GR,

and their parents: a tool to estimate environmental

clinical trials in cystic fibrosis. Gonska T, Ip W,

Forrester M, Hannigan GE, Malkin D

exposure to drugs of abuse. Garcia-Bournissen F,

Bear C, Quinton P, Durie P

Nesterenko M, Koren G Grafodatskaya D, Clinical and Metabolic Genetics

Elbers J, Neurology Small-vessel CNS vasculitis in childhood: clinical

Gillis J, Clinical and Metabolic Genetics

Search for epigastric changes using agilent CpG-

and pathological correlation. Elbers J, Halliday W,

A novel karyotype involving a pericentric X

island microarrays in children with autism born after

Hawkins C, Benseler S

chromosome inversion and mosaicism for two

assisted conception. Grafodatskaya D, Lou Y, Zhao C,

cell lines with different 5p deletions, presenting

Scherer S, Weksberg R

Faghfoury H, Clinical and Metabolic Genetics

as neonatal hyperammonemia. Gillis J, George A,

Interstitial deletion of chromosome (10)

Shago M, Antinucci D, Feigenbaum A, Rohrbach M

Faghfoury H, Summers AM, Li C

Guttman O, Gastroenterology, Hepatology and Nutrition Biliary atresia with associated structural

(q23.32q24.1) in a mother and her two offspring. Glatstein M, Paediatric Emergency Medicine

malformations: the Canadian Multicentre Study from

Clinical and radiologic predictors of hyponatremia

1985-2002. Guttman OR, Schreiber RA, Barker CC,

Ferreira J, Choufani S, Clinical and Metabolic Genetics

in children hospitalized with pneumonia. Glatstein M,

Ng VL, Roberts EA, the Canadian Paediatric

DNA methylation profiling in placentas of intra-uterine

Parkin P, Freedman S, Miller E

Hepatology Research Group

growth restricted fetuses and normal controls using agilent CPG island microarrays. Ferreira J, Grafodatskaya D, Choufani S, Weksberg R

180 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Hamud O, Neonatology

Hutchinson C, Rheumatology

Kim J, Nephrology

Clinical presentation and management of

Open label study for treatment of angiography-

The role of suppressor of fused in cerebellar

supraventricular tachycardia (SVT) in neonates.

negative, biopsy-positive primary CNS vasculitis in

development. Kim J, Gill P, Zhang M, Hui CC,

Hamud O, Lee K-S

children. Hutchinson C, Elbers J, Halliday W, Branson H,

Rosenblum ND

Laughlin S, Armstrong D, Hawkins C, Benseler SM Hawkes M, Infectious Diseases

Klieger-Grossmann C,

CD36 deficiency confers relative resistance

Hutter D, Cardiology

Clinical Pharmacology and Toxicolgy

to mycobacterial infection. Hawkes M, Li X,

The use of inhaled nitric oxide in the Critical Care Unit,

The safety of quinolones in the first trimester

Crockett M, Diassiti A, Liu J, Kain KC

The Hospital for Sick Children, Toronto: a retrospective

of pregnancy: a meta-analysis. Klieger-Grossmann C,

review 1994-2006. Hutter D, Sambamoorthi S, Humpl T

Boskovic R, Moretti M, Koren G

Jain S, Clinical and Metabolic Genetics

Koifman A, Clinical and Metabolic Genetics.

Hiraki L, Rheumatology Predicting macrophage activation syndrome (MAS) in paediatric systemic lupus erythematosus (pSLE)

Gender identity in males with 46XX congenital

Diaphragmatic hernia – limb abnormalities

patients at diagnosis. Hiraki LT, Tyrrell PN,

adrenal hyperplasia. Jain S, Zucker K, Wherrett D

syndrome (Froster syndrome). Koifman A, Shannon P, Kingdom J, Chitayat D

Benseler SM, Abdelhaleem M, Silverman ED Johnson K, Developmental Paediatrics Huber J, Core Paediatrics

Books for siblings of children with autism: children’s

Koltin D, Endocrinology

An investigation of body composition, metabolic rate

assessments. Johnson K, McKeever P, Kawamura A

Medication induced diabetes during induction

and body mass in children and adults with Prader-Willi

therapy in paediatric acute lymphoblastic leukaemia.

syndrome enrolled in an obesity intervention program.

Jurencak R, Rheumatology

Huber J, Balko K, Berall G

Expression of interleukin-17 in synovial fluid and peripheral blood in juvenile idiopathic arthritis.

Kumar S, Rheumatology

Hussey S, Gastroenterology, Hepatology and Nutrition

Jurencak R, Duong TT, Chung L, Feldman BM, Yeung RSM

B cell depletion for autoimmune thrombocytopenia

Prospective study of major upper gastrointestinal hemorrhage in children. Hussey S, Kelleher K, Ling SC

Koltin D, Sung L, Naqvi A, Urbach SL

and autoimmune hemolytic anaemia in paediatric Kavadas F, Immunology and Allergy

systemic lupus erythematosus. Kumar S,

High-dose methylprednisolone is effective in

Benseler S, Kirby-Allen M, Silverman E

the management of acute GvHD. Kovadas FD, Somech R, Atkinson A, Grunebaum E, Roifman CM

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 181

Lara-Corrales I, Paediatric Medicine

Maegawa G, Clinical and Metabolic Genetics

Mittal A, Neonatology

The efficacy of trimethoprim in wound healing

Juvenile GM2 gangliosidosis: a model for investigation

PDA categorization predicts post-ligation need for

of patients with epidermolysis bullosa: a randomized,

of small molecule therapies for lysosomal storage

cardiotropes. Mittal A, Dos Santos S, Hellmann J, Lee K-S, McNamara PJ

double blinded, placebo-controlled, cross-over pilot

diseases. Maegawa GHB, Banwell B, Tropak M,

study. Lara-Corrales I, Parkin P, Stephens D,

Buttner J, Rigat B, Hawkins C, Ackerley C,

Weinstein M, Sibbald G, Pope E

Hayes J, Tifft C, Tlopak M, Sorge G, Blaser S, van Giersbergen P, Clarke JTR, Mahuran DJ

Lau M, Neonatology The role of secondary septation during lung development. Lau M, Tanswell AK Lavine E, Immunology and Allergy

Lee Chong A, Haematology/Oncology

Maguire J, Paediatric Medicine Is iron deficiency anaemia an additive risk factor

Muise A, Gastroenterology, Hepatology and Nutrition

for stroke in children who have major risk factors

Defects in E-cadherin are associated with its

for stroke? Magurie J, deVeber G, Parkin P

cytoplasmic accumulation and with NOD2 polymorphisms in Crohn’s disease patients.

Makhani N, Neurology

Muise AM, Walters T, Glowacka W, Griffiths AM,

Safety and efficacy of cyclophosphamide for the

Ngan B-Y, Lan H, Xu W, Silverberg MS, Rotin D

treatment of paediatric multiple sclerosis. Makhani N

Curative cures? Lee Chong A, Grant R, Ahmed B, Thomas K, Connolly B, Greenberg M

Is perceived injury risk a barrier to physical activity participation in children? Mistry N, Birken CS, Parkin P

CD8 lymphopenia and Omenn syndrome. Lavine E, Kavadas F, Atkinson AR, Grunebaum E, Roifman CM

Mistry N, Core Paediatrics

Nahum A, Immunology and Allergy Mallik M, Nephrology

Chronic mucocutaneous candidiasis clinical and

The neuronal guidance cue slit 2 impairs monocyte

laboratory classification. Nahum A, Roifman CM

Lewis P, Neonatology

chemotaxis while preserving macrophage

Effects of prolonged exposure to inhaled nitric oxide

phagocytosis. Mallik M, Rui-Crow M, Yan H,

Nashed A, Respiratory Medicine

(INO) on established chronic hypoxic pulmonary

Chaukos D, Robinson LA

Pulmonary hypertension and sleep disordered

Kantores C, Van Vliet T, McNamara PJ, Jankov RP

Mateo P, Neonatology

A Riekstins, J MacFarlane, T Humpl, I Narang

Lim S, Rheumatology

of abnormal neurological outcome in severe

O’Gorman C, Endocrinology

Osteopenia and osteoporosis already present

hyperbilirubinemia. Mateo PC, Colantinio G,

Appetite-related hormone levels in patients with

in newly diagnosed juvenile systemic lupus

Blaser S, Moore AM

craniopharyngioma and hypothalamic obesity.

hypertension in neonatal rats. Lewis P, Xu E,

breathing in children. A Nashed, S Al-Saleh, Magnetic resonance imaging (MRI) in prediction

erythematosus (JSLE) patients. Lim SH,

O’Gorman CS, Simoneau-Roy J, Pencharz P,

Tyrrell P, Benseler S, Silverman ED

Adeli K, Hamilton J

182 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

Parkash S, Clinical and Metabolic Genetics

Principi T, Paediatric Emergency Medicine

Seltz LB, Paediatric Medicine

Van Allen-Myhre syndrome: report of a new case

What happens to oxygen saturation after discharge

Do children with complex febrile seizures require

with chondrodysplasia punctata. Parkash S, Keating S,

in outpatients with acute bronchiolitis? Principi T,

routine lumbar puncture to exclude bacterial or

Kolomietz E, Toi A, Chitayat D

Coates A, Parkin P, Da Silva Z, Schuh S

herpes simples virus (HSV) meningitis/encephalitis? Seltz LB, Cohen E, Weinstein M

Parker M, Paediatric Emergency Medicine

Raju D, Gastroenterology

Predictors of major intervention in infants with

Expression of fractalkine (CX3CL1) and its

bronchiolitis. Parker MJ, Allen UD, Lalani A,

involvement in helicobacter pylori infection.

Prevalence of microcytic anaemia in children 12 to 38

Stephens D, Schuh S

Raju D, Terebiznik M, Tole S, Robinson L, Jones N

months of age assessed by suspected child abuse

Pasic I, Clinical and Metabolic Genetics

Rimon Babad A, Paediatric Emergency Medicine

Contribution of DNA copy-number variation (CNV)

Paediatric omental infarction. Rimon Babad A,

to cancer susceptibility and large-scale genome

Gerstle JT, Daneman A, Ratnapalan S

Sharma N, Paediatric Medicine

and neglect team at The Hospital for Sick Children.

alterations in osteosarcoma (OS). Pasic I, Shlien A,

Sharma N, Shouldice M, Mekky M, Parkin P Sherlock M, Gastroenterology, Hepatology and Nutrition Infliximab maintenance therapy in paediatric

Novokmet A, Pinto D, Scherer SW, Malkin D

Scheinemann K, Haematology/Oncology

Crohn’s disease: the impact of discontinuation

High morbidity but low mortality in childhood spinal

of concomitant immunomodulation. Sherlock M,

Phongsamart W, Infectious Diseases

cord low grade gliomas. Scheinemann K, Bartels U,

Benchimol EI, Walters T, Turner D, Zachos M, Griffiths AM

Cytomegalovirus in paediatric haematopoietic stem

Huang A, Hawkins C, Bouffet E, Tabori U

cell transplantation at The Hospital for Sick Children,

Shlien A, Haematology/Oncology

2003-2007. Phongsamart W, Doyle J, Gasses A,

Schmeling H, Rheumatology

Excessive germline copy number variations in the

Tellier R, Grunebaum E, Allen U

Nail fold capillary density is strongly associated over

Li-Fraumeni cancer predisposition disorder. Shlien A,

time with muscle and skin disease activity in juvenile

Tabori U, Pienkowska M, Marshall CR, Nanda S,

Porepa M, Core Paediatrics

dermatomyositis. Schmeling H, Stephens S, Goia C,

Druker H, Novokmet A, Feuk L, Scherer SW, Malkin D

Evaluating the impact of a child-driven health

Manlhiot C, Schneider R, Luthra S, Feldman BM

magazine with children from an urban, multicultural,

Smile S, Developmental Paediatrics

low-income elementary school. Porepa M, Huber JF,

Schneiderman-Walker J, Respiratory Medicine

Randomized control study of melatonin for

Lam C, Mekky M, Au H, Birken CS

Assessment of body composition in paediatric

children with autism and sleep difficulties.

patients with cystic fibrosis. Schneiderman-Walker J,

Smile S, Roberts W, Weiss S

Heale L, Wells GD, Wilkes DL, Ratjen F, Coates AL

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT 183

So J, Clinical and Metabolic Genetics

Tanaka T, Clinical Pharmacology and Toxicology

Wells G, Respiratory Medicine

The CYLD tumour suppressor sensitizes cells

The incidence of poor neonatal adaptation syndrome

Skeletal muscle abnormalities in cystic fibrosis.

to microtubule destabilization. So J, Huber M,

following exposure to venlafaxine in late pregnancy.

Wells GD, Wilkes DL, Schneiderman-Walker J

Kohler A, Krauss S, Schweiger S, Schneider R

Tanaka T, Choi J, Einarson A, Koren G, Ito S

Rayner T, Elmi M, Selvadurai H, Ratjen F, Noseworthy M, Tein I, Coates A

Soylu H, Neonatology

Truong T, Haematology/Oncology

Rupture of membranes before the age of viability

Treatment-related complications in a young girl

Werner K, Neurology

increases adverse outcomes for preterm infants:

with acute lymphoblastic leukaemia may be due to

A MELAS-like phenotype presenting with ND3

a case control study. Soylu H, Diambomba Y,

uncovered mutations in the PKD1 and MTHFR genes.

mutations and Rolandic encephalopathy. Werner K

Jefferies A, Shah PS

Truong TH, Nanda S, Meyn MS, Grant R

Sugiyama I, Neurology

Villani A, Core Paediatrics

Williams V, Neonatology Withdrawal of artificial hydration and nutrition

Synthetic aperture magnetometry-kurtosis

Inherent diagnostic and treatment challenges in

in the NICU: A humane practice in tragic situations.

for presurgical evaluation of tuberous

germinoma of the basal ganglia: a case report and

Williams C, Ives-Baine L, Shah P, Hellmann J

sclerosis complex. Sugiyama I

review of the literature. Villani A, Bouffet E, Blaser S, Millar B-A, Hawkins C, Bartels U

Yaghoobi M, Clinical and Metabolic Genetics

Nuclear factor (erythroid 2-related) protein 2

Walsh C, Gastroenterology, Hepatology and Nutrition

of gastric cancer: a meta-analysis. Yaghoobi M,

counteracts bile acid-induced hepatotoxicity:

Simulation training in gastrointestinal endoscopy:

Bijarchi R

involvement of ABC transporters. Tan KP,

low versus high fidelity. Walsh CM, Cooper MA,

Wood GA, Yang M, Kosuge K, Ito S

Rabeneck L, Carnahan H

Tan M, Neurology

Waters A, Nephrology

loss in 60% oxygen-induced neonatal rat lung injury.

Alleviation of cerebral venous obstruction in supine

Slit diaphragm defects precede proteinuria

Yi M, Masood A, Jankov R, Tanswell AK

Tan KP, Clinical Pharmacology and Toxicology

Impact of family clustering on the risk of development

Yi M, Neonatology Inhibition of neutrophil influx protects against vessel

lying neonates with use of a custom-designed pillow.

in podocyte-specific notch-ic transgenic mice.

Tan M, Kirton A, Miller E, Shroff M, Deverber G

Waters A, Wu M, Onay T, Piscione T

184 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PAEDIATRICS 2007-08 ANNUAL REPORT

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