Journal of Innate Immunity

Novel Concepts in Innate Immunity 23–25 September 2015 Tübingen, Germany

Programme & Abstracts www.innate-immunity-conference.de

Did You

Know?

Conventus is the professional Congress Organiser for the Novel Concepts in Innate Immunity Meeting 2015 (NCII).

Table of Contents Organisation and Imprint . .....................................................................................

4

Welcome Note ..........................................................................................................

5

General Information Registration . ................................................................................................ Opening Hours.............................................................................................. Travel ............................................................................................................. Certification .................................................................................................. Information for Speakers . .........................................................................

6 6 7 8 8

Social and Cultural Programme . ...........................................................................

9

Sponsors and Exhibitors . .......................................................................................

12

Programme Overview .............................................................................................

13

Scientific Programme . ............................................................................................

14

Poster Sessions ........................................................................................................

20

Index of Invited Speakers, Presenting Authors and Chairs .............................

29

3

Organisation and Imprint Venue Eberhard Karls Universität Tübingen Kupferbau University Tübingen Hölderlinstraße 5 72074 Tübingen

Date 23–25 September 2015

Conference Website www.innate-immunity-conference.de Local organisation Jun.-Prof. Alexander Weber, PhD Eberhard Karls Universität Tübingen Interfaculty Institute of Cell Biology Department of Immunology Auf der Morgenstelle 15 72076 Tübingen Conference Chairs Alexander Weber Dominik Hartl Hans-Georg Rammensee Jan Wehkamp Martin Röcken Conference Organisation and Industrial exhibition Conventus Congressmanagement & Marketing GmbH Felix Angermüller/Anja Hannawald Carl-Pulfrich-Straße 1 07745 Jena, Germany Phone +49 3641 31 16-301/-327 Fax +49 3641 31 16-243 [email protected] www.conventus.de Design/Layout Layout Circulation Print Editorial Deadline

4

www.krea.tif-design.de 300 www.foebo.de 08 September 2015

Welcome Note by the conference chairs Dear Friends and Colleagues, Welcome to our Novel Concepts in Innate Immunity (NCII) 2015 meeting and to the beautiful University town of Tübingen. Thank you for choosing to join us! The NCII 2015 meeting is seeking both to commemorate the 30th anniversary of the discovery of the Toll receptor gene and to provide a platform for the discussion of the most recent developments in the dynamic field of innate immunity. We were intent on bringing some of the most prominent researchers in this field to Tübingen and are especially pleased that two Nobel laureates, Prof. Christiane Nüsslein-Volhard and Prof. Jules Hoffmann, will adorn the scientific program. We are very grateful to all speakers for their willingness to contribute to what we expect to be a very interesting scientific program. It is exciting to note that many PhD students have signed up to learn about innate immunity and to share some of their data. If you are an expert in the field or a senior researcher, we would very much appreciate it if you could make yourself available during poster sessions or in informal conversations in order to share some of your experience and knowledge in the field. We are certain that the students will reap great benefits from your feedback and advice. Thank you for this in advance. We hope that all participants will thoroughly enjoy the science that is on offer and will feel at home in Tübingen, with its rich cultural heritage and culinary delights. By participating in the social program and mingling in front of posters or during coffee breaks there will be many opportunities not only for scientific discussion but also for getting to know one another personally. We thank the German Society for Immunology (DGfI), the German Research Foundation (DFG), the European Molecular Biology Organization (EMBO), Tübingen University and University Hospital and all other academic and industrial sponsors and exhibitors for their generous support. Collectively, we look forward to an exciting meeting and to welcoming you in Tübingen. Best wishes,

Alex Weber Martin Röcken

Hans-Georg Rammensee Jan Wehkamp

Dominik Hartl

5

General Information Registration Registration for the conference is required. Please register online at www.innate-immunity-conference.de. Registration Fees Regular Students* Students from Tübingen*

300 EUR 250 EUR 100 EUR

Conference Dinner Regular Students

60 EUR 40 EUR

* Please send a confirmation of your status either to [email protected] Fax +49 3641 31 16-244 or by mail to Conventus GmbH • Carl-Pulfrich-Straße 1 07745 Jena (DE) indicating the keyword: NCII.

Payment and Confirmation of Payment An invoice or confirmation of registration will be sent to you via postal or electronic mail within 14 days. This invoice is a valid invoice which may be submitted to the local tax and revenue office. All fees are due upon receipt of in-voice/registration confirmation. Payment transfers must include participant’s name and invoice number. Payment is also accepted by credit card (Master-/Eurocard, American Express, VISA). Should you transfer your invoice amount within 10 days of the start of the event, please present your transfer remittance slip onsite. Accommodation A special Link of the City-Marketing can be used for booking accommodation. Please refer to www.innate-immunity-conference.de. Opening hours Check-In Media Check-In Industrial Exhibition

6

Wednesday 12.00–20.00 12.00–20.00 16.00–20.00

Thursday 08.00–18.30 08.00–16.30 10.00–16.00

Friday 08.00–13.30 08.00–11.30 10.00–13.30

General Information Travel

By train DB German Rail Event Ticket In cooperation with DB German Rail and Conventus you travel safely and conveniently to the Novel Concepts in Innate Immunity (NCII) in Tübingen. The price for your event ticket of a return trip* to Tübingen is: 2nd class 99 EUR (for a defined train connection) 1st class 159 EUR (for a defined train connection) 2nd class 1st class



139 EUR (for all trains) 199 EUR (for all trains)

* Changes and reimbursement before the first day of validity are 15 EUR excluded from the first day of validity onwards. Passengers restrict themselves to a particular train and travel times. For a supplement of 40 EUR full flexible tickets are also available.

Please find more detailed information on conditions and booking at www.innate-immunity-conference.de/travel-hotels/travel.

By car Tübingen can be reached from the motorway A8 and A81. From A8: Please take the exit 52a-Stuttgart-Möhringen onto B27 towards Filderstadt. Follow the signs towards Tübingen. From A81: Please take exit 29-Rottenburg onto B28a towards Tübingen. A car park is available right next to the Kupferbau. You can use the following parking garage nearby the conference venue: Parkhaus Brunnenstraße Brunnenstraße 29 • 72074 Tübingen • 7 minutes walk to the conference venue open 24 hours a day Parking fees: Mon–Sat, 8.00–19.00: 0,50 EUR/1h; days highest rate: 5 EUR; 19.00– 08.00, night fee: 1 EUR

By plane Stuttgart airport is the closest airport to Tübingen. A journey from Stuttgart airport to Tübingen takes about 25 minutes by taxi. The airport also offers a shuttle bus (Airport-Sprinter) to the train station of Tübingen for a small price. The bus line 828 runs every 30 minutes from Monday to Friday and on the weekends every hour. The journey takes about 45 minutes. For more details please refer to DB Regiobus Stuttgart.

7

General Information Certification The attendance of the conference is recognised by the Landesärztekammer BadenWürttemberg with 15 points in category A. Proof of Attendance For certification you must provide proof of attendance. Therefore please add your bar code to the list and sign it at the check-in desk, on-site at the conference. Certificate of Attendance Certificates of attendance will first be made available on the last day of the conference at the check-in desk. Submitting your presentation/technical information Please prepare your presentation in 4:3 aspect ratio. A presentation notebook with a PDF reader and MS Office PowerPoint 2007 will be provided. The use of personal notebooks is possible upon agreement. Please provide an adapter for VGA if necessary. A notebook, presenter and laser pointer are available at the speaker’s podium in the lecture hall. A technical supervisor will help you. Speakers preparation Please submit your presentation at the media check-in in the lecture hall no later than 90 minutes before the presentation begins. You may view and/or edit your presentation. For submission, please use a USB flash drive. Poster Session All posters will be shown during the poster session on Wednesday, 23 September 2015, 19.45–21.45. Posters should be prepared in size DIN A0 (width 84.1 cm x height 118.9 cm) and not laminated. Mounting materials will be provided. Poster authors are asked to be present at their poster during the poster session. The posters should be removed by Thursday, 24 September 2015, 16.30. Poster prizes, kindly sponsored by CureVac GmbH will be awarded on Friday, 25 September, after the last session (around 12:45).

8

Social and Cultural Programme “Spätzle”-Aktion Get a taste of the typical Tübingen delicacy, “Spätzle”, a regional type of home-made pasta which inspired the naming of a Drosphila gene by Christiane Nüsslein-Volhard and colleagues. The gene Spätzle encodes a ligand for the Drosophila Toll receptor. Date Time Venue Fee

Wednesday, 23 September 2015 18.30–19.00 Foyer Conference Venue free

© fotolia.com/kab-vision

Get Together We would like to welcome and invite you to the first evening of the conference. Let’s come together and meet your colleagues and friends and have some interesting conversations while enjoying cool drinks and snacks. Date Time Venue Fee

Wednesday, 23 September 2015 © arsenalkinos.de 19.45–21.45 Industrial exhibition area in the conference venue free, registration required

Conference party at Café Haag Don’t miss our great conference party after the Get Together. Listen to the music of the UKT Rock-Pop Band “Neri & Sons” while enjoying some drinks at Café Haag in Tübingen. Date Time Venue Fee

Wednesday, 23 September 2015 © CandyBox Images • fotolia.com from 21.30 Café Haag, Am Haagtor 1, 72070 Tübingen 12 min walk from the conference venue free

9

Social and Cultural Programme Guided tour: Classic tour of the old town The classic tour is the right choice, if you are still unacquainted with Tübingen! On this guided tour you will learn many interesting and entertaining facts about Tübingen’s past and present, about important buildings and famous faces in approx. 100 minutes. Naturally our tour guides will be able to tell you about the everyday life of the citizens, about funny and strange happenings and about what makes Tübingen so special and different.

© Jens Hilberger • fotolia.com

©tuebingen-info.de

Date Time Meeting point Duration Language Fee Max. number

Thursday, 24 September 2015 13.00 Tourist Center, An der Neckarbrücke 1, 72072 Tübingen 100 min German 10 EUR 25

Guided Tour: Punting trip The punting boat can no longer be separated from Tübingen. It belongs to the town and to the Neckar in the same way as the University and science do. Punting is a swabian leisure activity and one that stimulates conversation. The passengers are seated along each side of the punt, parallel to each other and relax against the high back-boards. We © gemeinfrei glide leisurely past the luxuriously green bank vegetation, “chat” to each other and admire the romantic scenery of the Tübingen Neckar Front – past the Hölderlinturm, the Burse and the Monastery. ©tuebingen-info.de

Date Time Meeting point Duration Language Fee Max. number

10

Thursday, 24 September 2015 13.00 Hölderlinturm, Bursagasse 60 min German 10 EUR 16

Social and Cultural Programme Social Evening – Restaurant “Die Kelter” The restaurant “Die Kelter” is located in the heart of the historic city center in Tübingen and invites you to a special interaction of creative cuisine and architecture. The historic wine-press building with its new integrated modern design gives an exciting and impressive atmosphere for the social evening. Enjoy the last evening of the conference with your colleagues and the comfortable and relaxing ambience. Date Time Fee Address

© diekelter-tuebingen.de

Thursday, 24 September 2015 20.00 Regular 60 EUR Students 40 EUR Schmiedtorstraße 17, 72070 Tübingen

© Bürger- und Verkehrsverein Tübingen Schloss Hohentübingen

11

Sponsors and Exhibitors We would like to thank the following companies for their support: Sponsors Adipogen Life Science (Liestal/CH) Biomol GmbH (Hamburg/DE) CureVac GmbH (Tübingen/DE) Invivogen SAS (Toulouse/FR) Jackson ImmunoResearch Europe Ltd. (Newmarket/UK) Microsynth (Balgach/CH) Exhibitors Adipogen Life Science (Liestal/CH) Becton Dickinson GmbH (Heidelberg/DE) BioLegend GmbH (Fell/DE) Biomol GmbH (Hamburg/DE) Biozol Diagnostica Vertrieb GmbH (Eching/DE) Bristol-Myers Squibb GmbH & Co. KGaA (Hartrampf/DE) eBioscience (Wien/AT) Hycult Biotech (Uden/NL) Invivogen SAS (Toulouse/FR) Miltenyi Biotec GmbH (Bergisch Gladbach/DE) Sony Europe Ltd. (Weybridge/GB) Media Cooperations GIT VERLAG GmbH & Co. KG (Weinheim/DE) G.I.T. Laboratory Journal Europe S. Karger AG (Freiburg/CH) Journal of Innate Immunity International Archives of Allergy and Immunology ELSEVIER Computational and Structural Biotechnology Journal Succidia AG (Darmstadt/DE) labor & more Please find information about transparency of the support of companies on the website www.innate-immunity-conference.de.

12

Programme Overview Wednesday, 23 Sept

Thursday, 24 Sept

Friday, 25 Sept

Lecture Hall 21

Lecture Hall 21

Lecture Hall 21

09.00–10.40

09.15–10.45

Innate lymphoid cells

Antiviral innate responses

Coffee and Industrial Exhibition

Coffee and Industrial Exhibition

11.10–12.40

11.15–12.45

Granulocytes and myeloid suppressor cells

Innate Immunity and disease 12.45–13.15

14.00–14:15 Opening

Lunch and Guided City Tours

Closing and Poster Award Ceremony

14.15–15.00 The EMBO Keynote Lecture Jules Hoffmann 15.00–16.30 Pattern recognition receptors Coffee and Industrial Exhibition 17.00–18.30

14.40–16.10 Host-Microbiome interaction Coffee and Industrial Exhibition 16.40–18.15 Antifungal innate responses

Inflammation and inflammasomes "Spätzle"-Aktion 19.00–19.45

19.30–23.00

Historical Keynote Christiane Nüsslein-Volhard 19.45–21.45 Welcome Reception and Poster Session

Conference Dinner Restaurant "Die Kelter"

from 21.30 Conference Party Café Haag

13

Scientific Programme • Wednesday, 23 September 2015 14.00–14.15 Room 14.15–15.00 Room Chairs 14.15 KN01 15.00–16.30 Room Chairs 15.00 S01-01 15.25 S01-02 15.50 S01-03 16.10 S01-04 17.00–18.30 Room Chairs 17.00 S02-01 17.25 S02-02

14

Opening Lecture Hall 21 The EMBO Keynote Lecture Lecture Hall 21 Alexander Weber, Hans-Georg Rammensee (Tübingen/DE) The Drosophila antimicrobial response – a paradigm for innate immunity Jules Hoffmann (Strasbourg/FR) Pattern recognition receptors Lecture Hall 21 Alexander Weber, Hans-Georg Rammensee (Tübingen/DE) How the discovery of Toll-like receptors changed Immunology Luke O’Neill (Dublin/IE) PQBP1 is a retrovirus-specific sensor mediating cGAS/IRF3-dependent innate responses Renate König (Langen/DE) Specialization of human myeloid Dendritic Cells Type 1 for extracellular pathogens Lukas Heger (Erlangen/DE) Remote control of intestinal tumorigenesis by the gut microbiota Matthias Chamaillard (Lille Cedex/FR) Inflammation and inflammasomes Lecture Hall 21 Amir Yazdi, Kamran Ghoreschi (Tübingen/DE) Posttranslational regulation of the NLRP3 inflammasome Eicke Latz (Bonn/DE) ATP-induced interleukin-1β release by human monocytic cells is inhibited by β-NAD Sebastian Hiller (Gießen/DE)

Scientific Programme • Wednesday, 23 September 2015 17.50 S02-03 18.10 S02-04 18.30–19.00 Room 19.00–19.45 Room Chairs KN02 19.45–21.45 Room

SLPI suppresses ATP-mediated release of IL-1β from human monocytes – evidence for a novel anti-inflammatory mechanism Anna Zakrzewicz (Gießen/DE)



Poster Antifungal innate responses........................................................... 20 Antiviral innate responses............................................................... 20 Granulocytes and myeloid suppressor cells.................................. 20 Host-Microbiome interaction........................................................... 21 Inflammation and inflammasomes................................................ 22 Innate immunity and disease.......................................................... 23 Innate lymphoid cells........................................................................ 26 Pattern recognition receptors......................................................... 27

from 21.30

Conference Party at Café Haag

Anti Inflammatory Properties of the Interleukin-1 Homologue IL-37 Philip Bufler (München/DE) “Spätzle”-Aktion see page 9 Foyer Historical Keynote Lecture Lecture Hall 21 Alexander Weber, Hans-Georg Rammensee (Tübingen/DE) Alexander Steinle (Frankfurt/DE) The discovery of the Toll Gene in Drosophila pattern formation Christiane Nüsslein-Volhard (Tübingen/DE) Get Together and Postersession Foyer

15

Scientific Programme • Thursday, 24 September 2015 09.00–10.40

Innate lymphoid cells – Sponsored by the DGfI Study Group NK Cell

Room Lecture Hall 21 Chairs Adelheid Cerwenka (Heidelberg/DE) Helmut Salih (Tübingen/DE) 09.00 Innate lymphoid cells – how tissue-resident immune cells S03-01 adapt organ function Andreas Diefenbach (Mainz/DE) 09.25 Crosstalk of innate lymphoid cells with the adaptive S03-02 immune system Daniela Finke (Basel/CH) 09.50 Activation and differentiation of group 3 innate lymphoid cells S03-03 Chiara Romagnani (Berlin/DE) 10.15 Innate lymphocytes-regulation by C-type lectin-like receptors S03-04 Alexander Steinle (Frankfurt am Main/DE) 11.10–12.40 Granulocytes and Myeloid suppressor cells Room Lecture Hall 21 Chairs Dominik Hartl, Julia Skokowa (Tübingen/DE) 11.10 Basophil-mediated protective immunity and S04-01 allergic inflamemation David Voehringer (Erlangen/DE) 11.35 In vivo imaging of [64Cu]-NOTA-CD11b-radiolabeled S04-02 granulocytic myeloid-derived suppressor cells in a murine PyMT breast cancer model by PET/MRI Sabrina Eilenberger (Tübingen/DE) 12.00 Proinflammatory role of myeloid derived suppressor S04-03 cells (MDSCs) in a glucose-6-phosphate isomerase (GPI)-induced T cell and B cell independent rheumatoid arthritis (RA) model, and tracking of granulocytic-MDSCs (G-MDSCs) in vivo using Positron Emission Tomography/Magnet Resonance Imaging (PET/MRI) Kerstin Fuchs (Tübingen/DE)

16

Scientific Programme • Thursday, 24 September 2015 12.20 S04-04 14.40–16.10 Room Chairs 14.40 S05-01 15.05 S05-02

Origin of and signals directing monocytic MDSC generation Manfred Lutz (Würzburg/DE)

15.30 S05-03 15.50 S05-04

Pro-Coagulant Microvesicles in the Early Host Defense against Streptococcus pyogenes Sonja Oehmcke-Hecht (Rostock/DE)

Host Microbiome Interaction Lecture Hall 21 Jan Wehkamp, Stella Autenrieth (Tübingen/DE) Implications of the microbiota in respiratory disease Eva Gollwitzer (Epalinges/CH) A Nasal Epithelial Receptor for Staphylococcus aureus WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization Christopher Weidenmaier (Tübingen/DE)

Ontogeny of the mucosal host-microbe interaction in the intestine Matthias Hornef (Aachen/DE)

17

Scientific Programme • Thursday, 24 September 2015 16.40–18.15 Room Chairs 16.40 S06-01 17.05 S06-02 17.30 S06-03 17.55 S06-04

Antifungal innate responses Lecture Hall 21 Martin Schaller, Dominik Hartl (Tübingen/DE)

19.30–23.00 Room

Social Evening see page 11 Restaurant “Die Kelter”

18

Antifungal defense at mucosal barriers Salome Leibundgut-Landmann (Zürich/CH) Novel insights in antifungal host-defense Frank van de Veerdonk (Nijmegen/NL) Neutrophils sense microbe size and selectively release NETs in response to large pathogens Nora Branzk (London/UK) Card 9 dependent signals in inflammation Jürgen Ruland (München/DE)

Scientific Programme • Friday, 25 September 2015 09.15–10.45 Antiviral innate responses Room Lecture Hall 21 Chairs Michael Schindler, Thomas Iftner (Tübingen/DE) 09.15 The Proteome under viral attack S07-01 Andreas Pichlmair (Martinsried/DE) 09.40 Intracellular nucleic acid sensing by the innate immune system S07-02 Veit Hornung (Bonn/DE) 10.05 Kinome-Wide siRNA Screen Reveals Novel Regulators of S07-03 the Antiviral RIG-I Signaling Pathway Joschka Willemsen (Heidelberg/DE) 10.25 Antiviral immunity and the interaction of neutrophils and S07-04 plasmacytoid dendritic cells Günther Schönrich (Berlin/DE) 11.15–12.45 Innate Immunity and Disease Room Lecture Hall 21 Chairs Thomas Kufer (Stuttgart-Hohenheim/DE) Lars Zender (Tübingen/DE) 11.15 Antimicrobial peptide in nucleic acid-driven innate immunity S08-01 Michel Gilliet (Lausanne/CH) 11.40 Epidermal NLRP10 contributes to contact hypersensitivity responses S08-02 Nora Mirza (Stuttgart-Hohenheim/DE) 12.05 Critical role of C-type lectin receptors in the pathogenesis of S08-03 cerebral malaria Bernd Lepenies (Potsdam/DE) 12.25 Origin and functional commitment of dermal macrophages S08-04 Philipp Henneke (Freiburg/DE) 12.45–13.15 Poster award ceremony and closing – Sponsored by CureVac GmbH (Tübingen DE) Room Lecture Hall 21

19

Poster Session Antifungal innate responses P01 Differential regulation of myeloid-derived suppressor cells by Candida species Anurag Singh (Tübingen/DE) P02 Recognition of Aspergillus fumigatus by Human Natural Killer Cells Jürgen Löffler (Würzburg/DE) P03 Role of PMNs in mucosal Candida albicans infection Christina Braunsdorf (Tübingen/DE) P04 Size dependent recognition of chitin by the innate immune system Katharina Fuchs (Tübingen/DE) Antiviral innate responses P05 The Role of TLRs in detection of MHV68 in vitro and in vivo Sripriya Murthy (Braunschweig/DE) Granulocytes and myeloid suppressor cells P06 The interaction between B lymphocytes and Myeloid-Derived Suppressor cells Felipe Lelis (Tübingen/DE) P07 Trafficking and functionality of suppressive regulatory immune cells – role of CFTR and implications for infective cystic fibrosis lung disease Hasan Halit Öz (Tübingen/DE) P08 Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice Kirsten Bucher (Tübingen/DE) P09 Decreased myelopoiesis after fibronectin deletion in osteoblasts increases liver fibrosis Eva Altrock (Heidelberg/DE) P10 Kinetic of myeloid-derived suppressor cells in chronic HIV-1 infection Eva Grützner (München/DE)

20

Poster Session P11 P12 P13

withdrawn T-cell subsets induce granulocytic myeloid-derived suppressor cells through a TNF-dependent mechanism and modulate their survival Markus Bauswein (Tübingen/DE) The myeloid derived suppressor cell- determined innate immunity is decisive for the chronic course of viral myocarditis Martina Sauter (Tübingen/DE)

Host-Microbiome interaction P14 The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodelling Thomas Kufer (Stuttgart-Hohenheim/DE) P15 Cross talk between T cells and antigen presenting cells during M. avium complex infection Ketema Abdissa Merga (Braunschweig/DE) P16 Escape of Staphylococcus aureus from within Phagocytes: a multifactorial Process Lisa Münzenmayer (Tübingen/DE) P17 Microbiome of the murine lung – development of in vitro systems Matthias Hauptmann (Borstel/DE) P18 The Protective Effect of the Skin Barrier against Bacterial Infection is Influenced by its Microbiota and the Interplay of Bacteria and Host-Derived Bioactive Peptides Marc Burian (Tübingen/DE) P19 Laminin-derived peptides are involved in inflammation, wounding and skin infections Ilknur Aschermann (Tübingen/DE)

21

Poster Session P20 P21 P22 P23 P24

Unique Wall Teichoic Acid Glycosylation mediated opsonophagocytic killing of Staphylococcus aureus Xuehua Li (Tübingen/DE) Influence of human TLR and NLR genetic variants on colorectal cancer – Involvement of commensal bacterial detection, gut immunity or microbiome diversity? Tharmila Sanmuganantham (Tübingen/DE) Is Galleria mellonella a useful model to study bacterial influence innate immunity? Anna Lange (Tübingen/DE) Plasminogen acquisition by Streptococcus pyogenes as a defense strategy against antimicrobial histones Ramona Nitzsche (Rostock/DE) The function of νSaα specific lipoprotein like cluster (lpl) of S. aureus USA300 on host signaling Minh Thu Nguyen (Tübingen/DE)

Inflammation and inflammasomes P25 A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants Nikolaus Rieber (Tübingen/DE) P26 Identification of novel determinants involved in regulation of human NLRP3 inflammasome signalling pathways using phospho-proteomics and interactomics approaches. Truong-Minh Dang (Tübingen/DE) P27 The NLRP3 inflammasome is regulated by post-translational modification Andrea Stutz (Bonn/DE) P28 Induction of myeloid-derived suppressor cells in cryopyrin-associated periodic syndromes Marlene Ballbach (Tübingen/DE)

22

Poster Session P29 P30 P31

Neutrophils release functionally active oligomeric ASC complexes Martina Bakele (Tübingen/DE) Inflammatory Caspases in intestinal homeostasis and inflammation Adrian Błażejewski (Braunschweig/DE) Bruton’s Tyrosine Kinase (BTK) is a novel regulator of the NLRP3 inflammasome Xiao Liu (Tübingen/DE)

Innate immunity and disease P32 Allergen pulsed dendritic cells that were activated with LPS and ATP induce a mixed Th2/Th17 response in the lung of mice leading to increased remodeling of the airways. Marcus Peters (Bochum/DE) P33 DC subpopulation specific changes of the cross-presentation machinery under inflammatory conditions Diana Dudziak (Erlangen/DE) P34 Antigen targeting of Fc-receptors induces strong T cell responses in vivo Christian H.K. Lehmann (Erlangen/DE) P35 Defective removal of ribonucleotides from DNA promotes systemic autoimmunity Claudia Günther (Dresden/DE) P36 TLR signaling is critical in NTHi-induced Otits media Anke Leichtle (Lübeck/DE) P37 Efferocytosis promotes survival of Mycobacterium tuberculosis. Tobias Dallenga (Borstel/DE) P38 Heparins and algae-derived glycans inhibit the CXCL12-induced activation of both CXCR4 and CXCR7 in human Burkitt’s lymphoma cells Inga Liewert (Kiel/DE)

23

Poster Session P39 P40 P41 P42 P43 P44 P45 P46 P47 P48 P49

24

Bacterial strain-dependency in the lethal synergism between Influenza A virus and Streptococcus pneumoniae Niharika Sharma (Braunschweig/DE) A novel octapeptide, derived from human ß-Defensin 1, as potential therapeutic Daniela Mailänder-Sanchez (Tübingen/DE) Cell-type specific requirement for TREX1 in the suppression of systemic autoimmunity Rayk Behrendt (Dresden/DE) C1 inhibitor potentiation by sulfated glycans is dependent on both their degree of sulfation and molecular weight Ann-Kathrin Schoenfeld (Kiel/DE) Diversity of kidney microenvirnoments affects dendritic cell signatureduring allograft rejection Zoran Popovic (Heidelberg/DE) Analysis of Dendritic Cells in human lymphoid organs Gordon Heidkamp (Erlangen/DE) HDAC related epigenetic alterations in inflammatory bowel diseases – A link to the antimicrobial barrier? Sabrina Stebe (Tübingen/DE) Modification of nlrp3 inflammasome gene expression level in the gut-associated lymphoid tissue in conditions of chronic social stress Inna Topol (Zaporozhye/UA) Molecular determinants of NLRC5-mediated MHC class I transcriptional regulation in human cells Felix Hezel (Stuttgart/DE) Basal nutrient stress sets up cellular tolerance to S. aureus α-toxin Gisela von Hoven (Mainz/DE) Slp-76 is a critical regulator of NK and iNKT cell responses Jochen Mattner (Erlangen/DE)

Poster Session P50 P51 P52 P53 P54 P55 P56 P57 P58 P59

A neonatal CNS infection model following mucosal challenge with Listeria monocytogenes Dennis Pägelow (Hannover/DE) Dietary wheat ATIs affect disease progression in MRL-Fas(lpr) mouse model of systemic lupus erythematosus. Victor Zevallos (Mainz/DE) Structure of the Factor H Sialic Acid Complex Links Faulty Self Recognition to Atypical Hemolytic Uremic Syndrome Bärbel Blaum (Tübingen/DE) Therapeutic relevance of mesenchymal stromal cells, myeloid-derived suppressor cells and regulatory T cells for the control of graft-versus-host disease Darina Brosch (Tübingen/DE) Impaired monocytes cause lower expression of α-defensins in Crohn’s disease Lioba Courth (Tübingen/DE) Two killing mechanism of the human ß-defensin 1 – Nanonets entrap Escherichia coli Judith Raschig (Tübingen/DE) Annexin A1/formyl peptide receptor axis regulates transfer of endotoxin tolerance Stefanie Seibert (Münster/DE) Bone marrow-derived dendritic cells from LPS challenged mice show altered immunological profiles Hübel Nicole (Münster/DE) Histones as components of the antimicrobial barrier of the human colonic mucosa Yasmin Kunkel (Stuttgart/DE) Somatic MyD88 mutations and a germline IRAK2 variant contribute to lymphoma by differential effects on NF-κB Olaf-Oliver Wolz (Tübingen/DE)

25

Poster Session P60

YadA-dependent interaction of Yersinia enterocolitica with vitronectin Melanie Mühlenkamp (Tübingen/DE)

P61 P62 P63 P64 P65

The Role of Matrix Metalloproteinase (MMP)-2 and MMP-9 in the peripheral immune response in Experimental Autoimmune Encephalomyelitis (EAE) Anna Chashchina (Muenster/DE)

P83

Activation of the inactive zymogen human complement factor D Elöd Körtvely (Tübingen/DE)

P84

withdrawn

Analysis of MYD88 splice variants in B-cell malignancies Yamel Cardona (Tübingen/DE) FliC of E. coli Nissle protects specific against DSS- induced colitis by activation of CD11c+ intestinal lamina propria cells Sarah Menz (Tübingen/DE) The FTD/ALS gene C9orf72 is highly expressed in CD14+ monocytes Emily Lynes (Tübingen/DE) Functionally relevant TLR9 promoter variants affect the course of hepatitis C virus infection in women Janett Fischer (Leipzig/DE)

Innate lymphoid cells P66 The IL-33 receptor (ST2) regulates early IL-13 in fungus-induced allergic airway inflammation Gottfried Alber (Leipzig/DE) P67 Resistance mechanisms of rhabdomyosarcomas to rhabdomyosarcoma-directed chimeric T Cells Katja Simon-Keller (Mannheim/DE) P68 Flt3L controls the number of innate lymphoid cells in fetal and adult mice Anne Bärenwaldt (Basel/DE)

26

Poster Session Pattern recognition receptors P69 The regulatory isoform rPGRP-LC resolves immune activation through ESCRT-mediated receptor clearance Claudine Neyen (Lausanne/DE) P70 2’-O-methylation within bacterial RNA suppresses activation of TLR-7/8 in human innate immune cells Alexander Dalpke (Heidelberg/DE) P71 Dectin-1 signaling is regulated by SPPL2 mediated intramembrane proteolysis Torben Mentrup (Kiel/DE) P72 Phenol soluble modulins – Bacterial agonists for leukocyte formyl peptide receptor 1 or 2? Dorothee Kretschmer (Tübingen /DE) P73 Identification of Toll-like Receptor 9 as Parapoxvirus Ovis-Sensing Receptor in Plasmacytoid Dendritic Cells Gottfried Alber (Leipzig/DE) P74 The intramembrane protease SPPL2a and its substrate CD74 influence distinct pattern recognition receptor signaling pathways in dendritic cells Ann-Christine Loock (Kiel/DE) P75 A novel RP105-PI3Kδ-innate signaling axis directs cytokine trafficking in mycobacteria-infected macrophages Antje Blumenthal (Brisbane/AU) P76 Recombinant mva generating excess early double-stranded rna transiently activates pkr and triggers enhanced innate immune responses Marc Schweneker (München/DE) P77 Endotoxin tolerance and the role of Bcl-3 in murine mast cells Magdalena Poplutz (Aachen/DE) P78 Oligothiophene-based chromophors to selectively label and study the myeloid cell compartment Marion Schneider (Ulm/DE)

27

Poster Session P79

Infl ammatory phenotype of Type 2 Diabetes Associated Macrophages Characterized by the Potassium Channel Kv1.3 and the Purinergic Receptor P2X7 Marion Schneider (Ulm/DE)

P80

Toll-like receptor activation in cell-based assays Stefanie Reuter (Jena/DE)

P81

Discovery of Novel TLR Antagonsits and Agonsits using a Toll: like Receptor Reporter Cell Line Angela Mattes (Stuttgart/DE)

P82

Toll-like receptor 9 in acute and chronic vascular injury Alexander Krogmann (Bonn/DE)

© Bürger- und Verkehrsverein Tübinger Stiftskirche

28

Invited Speakers, Presenting Authors and Chairs A Alber, G. Altrock, E. Aschermann, I. Autenrieth, S.

26, 27 20 21 17

B Bakele, M. Ballbach, M. Bärenwaldt, A. Bauswein, M. Behrendt, R. Blaum, B. Błażejewski, A. Blumenthal, A. Branzk, N. Braunsdorf, C. Brosch, D. Bucher, K. Bufler, P. Burian, M.

23 22 26 21 24 25 23 27 18 20 25 20 15 21

H Hartl, D. Hauptmann, M. Heger, L. Heidkamp, G. Henneke, P. Hezel, F. Hiller, S. Hoffmann, J. Hornef, M. Hornung, V. Hoven, G. von

C Cardona, Y. Cerwenka, A. Chamaillard, M. Chashchina, A. Courth, L.

26 16 14 26 25

D Dallenga, T. Dalpke, A. Dang, T.-M. Diefenbach, A. Dudziak, D. Eilenberger, S.

23 27 22 16 23 16

K König, R. Körtvely, E. Kretschmer, D. Krogmann, A. Kufer, T. Kunkel, Y.

F Finke, D. Fischer, J. Fuchs, Ka. Fuchs, Ke.

16 26 20 16

G Ghoreschi, K. Gilliet, M. Gollwitzer, E. Grützner, E. Günther, C.

I Iftner, T.

L Lange, A. Latz, E. Lehmann, C. H. Leibundgut-Landmann, S. Leichtle, A. Lelis, F. Lepenies, B. Li, X. Liewert, I. Liu, X.

14 19 17 20 23 16, 18 21 14 24 19 24 14 14 17 19 24 19 14 26 27 28 19, 21 25

22 14 23 18 23 20 19 22 23 23

29

Invited Speakers, Presenting Authors and Chairs S Salih, H. Sanmuganantham, T. Sauter, M. Schaller, M. Schindler, M. Schneider, M. Schoenfeld, A.-K. Schönrich, G. Schweneker, M. Seibert, S. Sharma, N. Simon-Keller, K. Singh, A. Skokowa, J. Stebe, S. Steinle, A. Stutz, A.

16 22 21 18 19 27, 28 24 19 27 25 24 26 20 16 24 15, 16 22

Löffler, J. Loock, A.-C. Lutz, M. Lynes, E.

20 27 17 26

M Mailänder-Sanchez, D. Mattes, A. Mattner, J. Mentrup, T. Menz, S. Merga, K. A. Mirza, N. Mühlenkamp, M. Münzenmayer, L. Murthy, S.

24 28 24 27 26 21 19 26 21 20

N Neyen, C. Nguyen, M. T. Nicole, H. Nitzsche, R. Nüsslein-Volhard, C.

27 22 25 22 15

T Topol, I.

24

V Van de Veerdonk, F. Voehringer, D.

18 16

O Oehmcke-Hecht, S. O’Neill, L. Öz, H. H.

17 14 20

P Pägelow, D. Peters, M. Pichlmair, A. Poplutz, M. Popovic, Z.

25 23 19 27 24

W Weber, A. Wehkamp, J. Weidenmaier, C. Willemsen, J. Wolz, O.-O. Y Yazdi, A.

R Rammensee, H.-G. Raschig, J. Reuter, S. Rieber, N. Romagnani, C. Ruland, J.

30

4, 5, 14, 15 25 28 22 16 18

Z Zakrzewicz, A. Zender, L. Zevallos, V.

14, 15 17 17 19 25 14 15 19 25

r to c a tF 2 c 5 pa 4.3 Im

Innate Immunity

Journal of

welcomes your contribution …

Heiko Herwald, Lund Arne Egesten, Lund Editorial Board B. Beutler, Dallas, Tex. V. Brinkmann, Berlin G.D. Brown, Aberdeen B. Dahlbäck, Malmö F.R. DeLeo, Hamilton, Mont. J. Hoffmann, Strasbourg M. Holub, Prague M. Hornef, Hannover T. Kaisho, Yokohama City J.D. Lambeth, Atlanta, Ga. G. McFadden, Gainsville, Fla. E. Medina, Braunschweig A. Mowat, Glasgow P.M. Murphy, Bethesda, Md. V. Nizet, La Jolla, Calif. J.E. Pease, London J. Potempa, Krakow C.S. Reiss, New York, N.Y. J.A. Russell, Vancouver, B.C. D. Schneider, Stanford, Calif. J.-M. Schröder, Kiel T. Seya, Sapporo O. Soehnlein, Munich C. Speth, Innsbruck U. Theopold, Stockholm J.A.G. van Strijp, Utrecht M.A. Williams, Bethesda, Md. V. Witko Sarsat, Paris M.A. Zasloff, Washington, D.C

The Journal of Innate Immunity is a bimonthly journal covering all aspects in the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications and reviews.

Benefits for Authors • Cost-effective publishing (no submission fee and no page charges for papers of 5 or fewer printed pages) • Free online color figures • Rapid and fair peer-review process • Full listing in all relevant bibliographic databases (PubMed/MEDLINE, Web of Science etc.) • Author‘s choice for open access publishing

Find out more:

www.karger.com/jin KI15405

Editor-in-Chief