Onsite Program Book

ASBMR 2011 Annual Meeting San Diego Convention Center San Diego, California, USA September 16-20, 2011 TABLE OF CONTENTS ASBMR Council/Staff .......................................................................................... v Program Committee ............................................................................................. v Abstract Reviewers ............................................................................................. vi ASBMR Committee Members/Representatives ........................................................... viii Award Winners ................................................................................................. xii Supporters ...................................................................................................... xiv General Information ........................................................................................... xv ASBMR Policies ................................................................................................ xv Continuing Medical Education Credit .................................................................... xvii Meeting Resource Materials ................................................................................. xix Travel Resources ................................................................................................ xx ASBMR Networking Center .................................................................................. xx Information for Speaker and Poster Presenters ......................................................... xxii THURSDAY, SEPTEMBER 15, 2011 ASBMR Registration Open FRIDAY, SEPTEMBER 16, 2011 Day-at-a-Glance ............................................................................................ 2 ASBMR Registration Open ............................................................................... 4 Plenary Symposium I - Muscle and Bone Interactions ............................................... 4 Meet-the-Professor Sessions ............................................................................... 4 Regulatory Opportunities and Challenges in Osteoporosis .......................................... 5 Meeting Overview for Health Professionals ............................................................ 5 Grant-Writing Workshop: Navigating the NIH Resubmission Process ........................... 6 Symposium – Osteoblast/Osteoclast Coupling ......................................................... 6 Symposium - Controversies and Concepts in Musculoskeletal Frailty ............................ 7 Symposium - Autophagy in Bone Health and Disease ............................................... 7 Symposium - Systems Approaches to Secondary Fracture Prevention: Doing Something that Actually Works .......................................................................................... 8 Welcome & Announcements .............................................................................. 8 Presentation of the ASBMR Louis V. Avioli Memorial Founders Award ....................... 8 Presentation of the ASBMR William F. Neuman Award ........................................... 8 ASBMR/ECTS Clinical Debate - Calcium Supplementation is Safe and Effective .............. 9 State-of-the-Art Lectures – New Concepts in Bone Remodeling ................................... 9 Oral Poster Session: Diabetes and Bone as an Endocrine Organ ................................... 9 Oral Poster Session: Vitamin D and Muscle and Bone ............................................. 10 Oral Poster Session: Vascular Calcification and Renal Bone ...................................... 11 Oral Poster Session: Osteoarthritis and Mechanotransduction .................................... 12 Posters and Exhibits Open ............................................................................... 13 Welcome Reception & Plenary Poster Session ........................................................ 13 Minority Investigator Reception ........................................................................ 39 New Investigator/New Member/First Time Attendee Reception .................................. 39 Young Investigator/Minority Investigator Networking Hour ...................................... 40 Pediatric Bone and Mineral Working Group ......................................................... 40 Working Group on Skeletal Aging ..................................................................... 40 In Vivo Working Group .................................................................................. 41

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Muscle and Bone Working Group ...................................................................... 41 SATURDAY, SEPTEMBER 17, 2011 Day-at-a-Glance ........................................................................................... 43 ASBMR Networking Breakfast ......................................................................... 45 ASBMR Registration Open .............................................................................. 45 Posters Open ............................................................................................... 45 Louis V. Avioli Memorial Lecture - Osteocytes - The Great Communicators .................. 45 Exhibits Open .............................................................................................. 45 Presentation of the ASBMR Gideon A. Rodan Excellence in Mentorship Award ............ 45 Presentation of the ASBMR Lawrence G. Raisz Award ........................................... 45 Coffee Break ................................................................................................ 45 Concurrent Oral Session 01: Osteoblasts .............................................................. 46 Concurrent Oral Session 02: Bone, Cartilage and Connective Tissue Matrix ................... 46 Concurrent Oral Session 03: Genetic Disorders of Bone ........................................... 47 Concurrent Oral Session 04: Osteoporosis Epidemiology: Biomarkers for Fracture ........... 48 Concurrent Oral Session 05: New Approaches to Osteoporosis Treatment (Preclinical) ...... 50 Concurrent Oral Session 06: John H. Carsten’s Memorial Session for Osteoporosis .......... 51 Meet-the-Professor Sessions .............................................................................. 52 Poster Session I & Poster Tours ........................................................................ 53 Special Lecture on Sarcopenia ......................................................................... 116 Meet-the-Professor Sessions ............................................................................ 116 Career Development: Building Interdisciplinary Collaboration in Research .................. 117 Clinical Roundtable/Case Conference - Anabolic Agents for Fracture Repair ................ 117 Concurrent Oral Session 07: Osteocytes ............................................................. 118 Concurrent Oral Session 08: Osteoclasts ............................................................. 119 Concurrent Oral Session 09: Calciotropic and Phosphotropic Hormones ..................... 120 Concurrent Oral Session 10: Osteoporosis Assessment: Prediction of Fracture Risk ........ 121 Concurrent Oral Session 11: Osteoporosis Treatment (Clinical): Anti-resorptive Treatment 122 Concurrent Oral Session 12: Bone Biomechanics and Quality: Animal Models .............. 123 Coffee Break .............................................................................................. 124 Clinical Update for Health Professionals ............................................................ 124 State-of-the-Art Lectures – Bone-Hematopoietic Interactions ................................... 125 Clinical Evening at ASBMR ........................................................................... 126 ASBMR Social Event - California Dreamin’ ....................................................... 126 SUNDAY, SEPTEMBER 18, 2011 Day-at-a-Glance ......................................................................................... ASBMR Registration Open ............................................................................ Posters Open ............................................................................................. Gerald D. Aurbach Memorial Lecture - MicroRNA Control of Muscle Development and Disease ................................................................................................. Exhibits Open ............................................................................................ Presentation of the ASBMR Fuller Albright Award ............................................. Presentation of the ASBMR Frederic C. Bartter Award ......................................... Coffee Break .............................................................................................. Concurrent Oral Session 13: Bone - Hematopoietic Interactions ................................ Concurrent Oral Session 14: Genetic Disorders of Bone and Mineral Metabolism .......... Concurrent Oral Session 15: Cancer and Bone ..................................................... Concurrent Oral Session 16: Osteoporosis Epidemiology: Fracture Risk in Specific Populations ............................................................................................ Concurrent Oral Session 17: Disorders of Mineral Metabolism ................................. Concurrent Oral Session 18: Human Studies in Bone Biomechanics and Quality ............ Meet-the-Professor Sessions ............................................................................ Poster Session II & Poster Tours ..................................................................... Meet-the-Professor Sessions ............................................................................ Biotechniques Workshop: Mouse Models ...........................................................

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127 130 130 130 130 130 130 130 130 131 133 134 135 136 137 137 199 200

Clinical Roundtable/Case Conference - Managing Musculoskeletal Disease in Chronic Renal Insufficiency .......................................................................................... Special Session: When a Reporter Calls: How to Communicate Your Research to the News Media .................................................................................................. Concurrent Oral Session 19: Steroid Hormones and Receptors ................................. Concurrent Oral Session 20: Growth Factors, Cytokines, Immunomodulators ............... Concurrent Oral Session 21: TGF- b and Bone Physiology ...................................... Concurrent Oral Session 22: Methods of Osteoporosis Assessment ............................ Concurrent Oral Session 23: Osteoporosis Treatment (Clinical) ................................. Concurrent Oral Session 24: Childhood Factors with Bone Acquisition ....................... Coffee Break .............................................................................................. Clinical Update for Health Professionals – IOM Report on Vitamin D ....................... State-of-the-Art Lectures - TRP Channel Signaling In Skeletal Physiology and Mineral Metabolism ............................................................................................ ASBMR Town Hall Meeting and Reception ....................................................... ASBMR Women in Bone and Mineral Research Committee Event – Getting What You Want: The Art of Negotiation .............................................................................. Non-Invasive Assessment of Bone Microarchitecture and Function Working Group ....... Adult Bone and Mineral Working Group ........................................................... Vitamin D Working Group ............................................................................ Bone Strength Working Group ....................................................................... MONDAY, SEPTEMBER 19, 2011 Day-at-a-Glance ......................................................................................... ASBMR Registration Open ............................................................................ Posters Open ............................................................................................. Plenary Symposium II – Lipotoxicity: Bad to the Bone .......................................... Exhibits Open ............................................................................................ Presentation of the ASBMR Paula Stern Achievement Award .................................. Presentation of the Shirley Hohl Service Award ................................................... Coffee Break .............................................................................................. Concurrent Oral Session 25: Osteoblasts ............................................................ Concurrent Oral Session 26: Bone, Cartilage and Connective Tissue Matrix & Development Concurrent Oral Session 27: Osteoclasts ............................................................. Concurrent Oral Session 28: Preserving Muscle and Bone During Aging ..................... Concurrent Oral Session 29: Osteoporosis Pathophysiology ..................................... Concurrent Oral Session 30: Hormonal and Metabolic Influence on Bone Acquisition ..... Poster Session III & Poster Tours* ................................................................... Meet-the-Professor Sessions ............................................................................ Advocating for Science in Challenging Times ...................................................... Clinical Roundtable/Case Conference - Monitoring Osteoporosis Therapy – To Scan or Not to Scan? ................................................................................................ Concurrent Oral Session 31: Genetic Disorders of Bone and Mineral Metabolism .......... Concurrent Oral Session 32: Osteoclasts ............................................................. Concurrent Oral Session 33: Growth Factors, Cytokines, Immunomodulators ............... Concurrent Oral Session 34: Anabolic Treatment for Osteoporosis ............................ Concurrent Oral Session 35: Wnt Pathway and Osteoporosis Treatment ...................... Concurrent Oral Session 36: Metabolic Influences in the Pathophysiology of Osteoporosis Coffee Break .............................................................................................. Concurrent Oral Session 37: Osteoblasts ............................................................ Concurrent Oral Session 38: Bone, Cartilage and Connective Tissue Matrix & Development Concurrent Oral Session 39: Cancer and Bone (Basic, Translational and Clinical) .......... Concurrent Oral Session 40: Skeletal Loading and Bone Quality ............................... Concurrent Oral Session 41: Risk of Typical and Atypical Fractures .......................... Concurrent Oral Session 42: New Aspects of Standard Osteoporosis Treatment ............. Molecular Biology and Pathology of Bone Working Group .....................................

200 200 201 202 203 203 204 205 206 206 207 207

207 208 209 209 210 212 215 215 215 215 215 215 215 216 217 218 219 220 221 222 281 282 283 283 284 285 286 287 288 289 289 290 291 292 293 294 295

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Working Group on Musculoskeletal Rehabilitation in Patients with Osteoporosis .......... 296 Working Group on Osteoporosis in Rheumatic Diseases ......................................... 297 TUESDAY, SEPTEMBER 20, 2011 Day-at-a-Glance ......................................................................................... Concurrent Oral Session 43: Osteoblasts ............................................................ Concurrent Oral Session 44: Osteoporosis Fractures and Clinical Outcomes ................. Coffee Break .............................................................................................. Plenary Symposium III – Novel Genetic and Epigenetic Approaches to Human Disease ..

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298 299 299 300 301

AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH (ASBMR) OFFICERS Sundeep Khosla, M.D., President Keith Hruska, M.D., President-Elect Jane B. Lian, Ph.D., Past-President Lynda F. Bonewald, Ph.D., Secretary-Treasurer Brendan Boyce, M.D., Secretary-Treasurer-Elect COUNCILORS John Adams, M.D. Teresita M. Bellido, Ph.D. Douglas P. Kiel, M.D., MPH Nancy Lane, M.D. Joseph Lorenzo, M.D. Masaki Noda, M.D, Ph.D. Eric S. Orwoll, M.D. G. David Roodman, M.D., Ph.D. Jennifer J. Westendorf, Ph.D. Thomas L. Clemens, Ph.D.

Term expires 2012 Term expires 2011 Term expires 2011 Term expires 2013 Term expires 2011 Term expires 2012 Term expires 2013 Term expires 2013 Term expires 2012 Ex-Officio 2012

ASBMR STAFF Alex Aaron, Exhibit Sales Coordinator Angela Cangemi, Program Manager Matthew Croll, Director of Finance Ann L. Elderkin, P.A., Executive Director Douglas Fesler, Associate Executive Director Robert Fulcher, Director of Publications Amy Goetz, Marketing Director Melissa Huston, Senior Convention Manager Michael Jordan, Meetings Associate Jessica Klapstein, Housing and Ancillary Meetings Coordinator Deborah Kroll, Director of Development Adair Landy, Senior Associate Earline Marshall, Senior Grants Administrator Kirsten Mills, Project Coordinator Jennifer Montague, Exhibits Associate Monica Nolden, Registration Coordinator Lindsay Pullen, Marketing Coordinator Brianna Stout, Associate Daniel Tadesse, Registration Manager David West, Accountant ASBMR BUSINESS OFFICE 2025 M Street, NW Suite 800 Washington, DC 20036-3309 USA Tel: +1 (202) 367-1161 Fax: +1 (202) 367-2161 E-mail: [email protected] Internet: http://www.asbmr.org 2011 PROGRAM COMMITTEE President: Sundeep Khosla, M.D. Program Co-Chair: Suzanne Jan De Beur, M.D. Program Co-Chair: Dwight A. Towler, M.D., Ph.D. 2011 Program Committee Disclosures Sundeep Khosla serves on the scientific advisory board for Bone Therapeutics and has received consulting fees from Pfizer, Inc. Suzanne Jan De Beur serves on the data safety and monitoring board for Kyowa Hakko Kirin Dwight A. Towler has nothing to disclose

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2011 Abstract Reviewers Yousef Abu-Amer, Ph.D. Matthew Allen, Ph.D. Laleh Ardeshirpour, M.D. Amitabha Bandyopadhyay, Ph.D., M.S. Zvi Bar-Shavit, Ph.D. Douglas Bauer, M.D. Maria Luisa Bianchi, M.D. Neil Binkley, M.D. Robert Blank, M.D., Ph.D. Jean-Philippe Bonjour, M.D. Mary Bouxsein, Ph.D. Wenhan Chang, Ph.D. Bart Clarke, M.D. Gregory Clines, M.D., Ph.D. Patricia Collin-Osdoby, Ph.D. Anne Delany, Ph.D. Robert Downs, M.D. Matthew Drake, M.D., Ph.D. Patricia Ducy, Ph.D. Colin Dunstan, Ph.D. Gustavo Duque, M.D., Ph.D. Michael Econs, M.D. Murray Favus, M.D. David Findlay, Ph.D. Lorraine Fitzpatrick, M.D. Renny Franceschi, Ph.D. Seiji Fukumoto, M.D., Ph.D. Dana Gaddy, Ph.D. Ju¨erg Andreas Gasser, Ph.D. Matthew Gillespie, Ph.D. Helmut Glantschnig Jeff Gorski, Ph.D. Agi Grigoriadis, Ph.D. Gloria Gronowicz, Ph.D. Elizabeth Haney, M.D. Marian Hannan, DSc, MPH Stephen Harris, Ph.D. Mohammad Hassan, Ph.D. Lorena Havill, Ph.D. Anne-Marie Heegaard, M.D., Ph.D. Geoffrey Hendy, Ph.D. Eric Hesse, M.D., Ph.D. Martin Hewison, Ph.D. Lynn Hocking, Ph.D. Ingrid Holm, M.D., MPH Keith Hruska, M.D. Sophie Jamal, M.D., Ph.D. Mark Johnson, Ph.D. Lynne Jones, Ph.D. David Karasik, Ph.D. Marcel Karperien, Ph.D. Jenneke Klein-Nulend, Ph.D.

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Barry Komm, Ph.D. Stavroula Kousteni, Ph.D. Christopher Kovacs, M.D. Richard Kremer, M.D., Ph.D. Marie-helene Lafage-proust, M.D. Daniel Lajeunesse, Ph.D. Beate Lanske, Ph.D. Meryl Leboff, M.D. Beata Lecka-Czernik, Ph.D. Michael Lewiecki, M.D., FACP, FACE Robert Lindsay, MBChB, Ph.D., FRCP Anne Looker, Ph.D. Pierre Marie, Ph.D. Laurie McCauley, D.D.S., Ph.D. Eugene McCloskey, M.D., MRCP, M.B. Jose Luis Millan, Ph.D. Howard Morris, Ph.D. Nigel Morrison, Ph.D., BSc Anja Nohe, Ph.D. Charles O’Brien, Ph.D. Toru Ogasawara, D.D.S., Ph.D. Robert Pignolo, M.D., Ph.D. Carol Pilbeam, M.D., Ph.D. Jerilynn Prior Nalini Rajamannan, M.D. Jean Regard, Ph.D. F. Patrick Ross, Ph.D. Peter Rowe, Ph.D. Janet Rubin, M.D. Cheryl Sanchez, M.D. Susan Schiavi, Ph.D., M.S. Markus Seibel, M.D., Ph.D. Deborah Sellmeyer, M.D. Elizabeth Shane, M.D. Eileen Shore, Ph.D. Stuart Silverman, M.D. Anna Spagnoli, M.D. Joseph Stains, Ph.D. Elizabeth Streeten, M.D. Elsa Strotmeyer, Ph.D., MPH Larry Suva, Ph.D. Sakae Tanaka, M.D., Ph.D. Yin Tintut, Ph.D. Slobodan Vukicevic, M.D., Ph.D. Nelson Watts, M.D. Robert Weinstein, M.D. Deborah Wenkert, M.D. Kenneth White, Ph.D. Bart Williams, Ph.D. Sunil Wimalawansa, Ph.D., M.D., FRCP Lianping Xing, Ph.D. Dean Yamaguchi, M.D., Ph.D. Alberta Zallone, Ph.D. Majd Zayzafoon, M.D., Ph.D.

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ASBMR COMMITTEE MEMBERS AND REPRESENTATIVES ADVOCACY COMMITTEE Mark L. Johnson, Ph.D., Chairperson Neil C. Binkley, M.D. Qian Chen, Ph.D. Renny T. Franceschi, Ph.D. Joan M. Lappe, R.N., Ph.D. Kenneth G. Saag, M.D., MSc Elizabeth Shane, M.D., Ex-Officio G. David Roodman, M.D., Ph.D., Council Liaison Ann L. Elderkin, P.A., Staff Liaison Douglas Fesler, Staff Liaison ANCILLARY PROGRAM COMMITTEE Eugene V. McCloskey, M.D., MRCP, M.B., Chairperson Robert D. Blank, M.D., Ph.D. Bart L. Clarke, M.D. Nandini Ghosh-Coudhury, Ph.D. Majd Zayzafoon, M.D., Ph.D. John S. Adams, M.D., Council Liaison Adair Landy, Staff Liaison Angela Cangemi, Staff Liaison EDUCATION COMMITTEE Marian T. Hannan, D.Sc., MPH, Chairperson Shreyasee Amin, M.D., MPH Sarah L. Dallas, Ph.D. Erik A. Imel, M.D. Yebin Jiang, M.D., Ph.D. Stavroula Kousteni, Ph.D. Masaki Noda, M.D., Ph.D., Council Liaison Angela Cangemi, Staff Liaison Adair Landy, Staff Liaison ETHICS ADVISORY COMMITTEE Murray J. Favus, M.D., Chairperson Kristina Akesson, M.D., Ph.D. Jane A. Cauley, Ph.D. Carol C. Pilbeam, M.D., Ph.D. Tamara J. Vokes, M.D. Katherine N. Weilbaecher, M.D. Jane B. Lian, Ph.D., Ex Officio Eric S. Orwoll, M.D., Council Liaison Ann L. Elderkin, P.A., Staff Liaison Earline Marshall, Staff Liaison FINANCE COMMITTEE Lynda F. Bonewald, Ph.D., Chairperson Mark C. Horowitz, Ph.D. Dwight A. Towler, M.D., Ph.D. John J. Wysolmerski, M.D. Sundeep Khosla, M.D., Ex Officio Keith A. Hruska, M.D., Ex Officio Brendan F. Boyce, M.D., Council Liaison Jennifer J. Westendorf, Ph.D., Council Liaison Ann L. Elderkin, P.A., Staff Liaison Matthew Croll, Staff Liaison

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MEMBERSHIP DEVELOPMENT COMMITTEE Wenhan Chang, Ph.D., Chairperson Marcel Edwards Marja Marie Hurley, M.D. David Karasik, Ph.D. Arabella I. Leet, M.D. Laura Masi, M.D., Ph.D. Kevin P. McHugh, Ph.D. Kristy M. Nicks, Ph.D. Eileen Shore, Ph.D. Teresita M. Bellido, Ph.D., Council Liaison Douglas Fesler, Staff Liaison MINORITY SUBCOMMITTEE Sherri-Ann M. Burnett-Bowie, M.D., MPH, Chairperson Jacqueline P. Akech, Ph.D. Sunday Akintoye, D.D.S. Sylvia Christakos, Ph.D. Jeanette N. Keith, M.D. Kristy M. Nicks, Ph.D. Roger Zebaze, M.D. Douglas Fesler, Staff Liaison YOUNG INVESTIGATOR SUBCOMMITTEE James R. Edwards, Ph.D., Co-Chairperson Ulrike I. Moedder, Ph.D., Co-Chairperson Jessica A. Fowler Francesco Grassi John R. Hawse, Ph.D. Meghan E. McGee-Lawrence Nadia Rucci, Ph.D. Leanne K. Saxon, Ph.D. Douglas Fesler, Staff Liaison PROFESSIONAL PRACTICE COMMITTEE Robert A. Adler, M.D., Chairperson Carolyn B. Becker, M.D. Richard S. Bockman, M.D., Ph.D. Susan V. Bukata, M.D. Howard A. Fink, M.D., MPH Karen E. Hansen, M.D. Salvatore Minisola, M.D. H. Alexander Wilson, M.D. Agne`s Vignery, D.D.S., Ph.D. Carol Zapalowski, M.D., Ph.D. Kathy M. Shipp, P.T., Ph.D., Ad Hoc Douglas P. Kiel, M.D., MPH, Council Liaison Douglas Fesler, Staff Liaison Ann L. Elderkin, P.A., Staff Liaison Kirsten Mills, Staff Liaison PUBLICATIONS COMMITTEE Philip Osdoby, Ph.D., Chairperson Douglas C. Bauer, M.D. Louis C. Gerstenfeld, Ph.D. Carlos M. Isales, M.D. Moustapha Kassem, M.D., Ph.D. Christopher S. Kovacs, M.D., FRCP Jane Mitchell, Ph.D. Tuan V. Nguyen, Ph.D.

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Thomas L. Clemens, Ph.D., Ex Officio Clifford J. Rosen, M.D., Ex Officio Joseph Lorenzo, M.D., Council Liaison Robert Fulcher, Staff Liaison PRIMER EDITORIAL BOARD - 8th Edition Clifford J. Rosen, M.D., Chairperson Douglas Bauer, M.D. Roger Bouillon, M.D., Ph.D. Juliet E. Compston, M.D., FRCP Marie Demay, M.D. Theresa A. Guise, M.D. Suzanne M. Jan De Beur, M.D. Richard W. Keen, M.D., Ph.D. Laurie K. McCauley, D.D.S., Ph.D. Paul D. Miller, M.D., FACP Socrates Papapoulos, M.D. Vicki Rosen, Ph.D. Ego Seeman, M.D., FRACP Rajesh V. Thakker, M.D., FRCP Mone Zaidi, M.D., Ph.D. Robert Fulcher, Staff Liaison SCIENCE POLICY COMMITTEE Paula H. Stern, Ph.D., Chairperson Yousef Abu-Amer, Ph.D. Anne M. Delany, Ph.D. Paola Divieti Pajevic, M.D., Ph.D. Matthew T. Gillespie, Ph.D. Thomas J. Rosol, D.V.M., Ph.D. Robert Adler, M.D., Ex Officio Mark L. Johnson, Ph.D., Ex Officio Brendan F. Boyce, M.D., Council Liaison Nancy Lane, M.D., Council Liaison Douglas Fesler, Staff Liaison Ann L. Elderkin, P.A., Staff Liaison WOMEN IN BONE AND MINERAL RESEARCH COMMITTEE Janine A. Danks, Ph.D., Chairperson Beatrice J. Edwards, M.D., FACP Claire M. Edwards, Ph.D. MiMi Hu, M.D. Mary Beth Humphrey, M.D., Ph.D. Melissa A. Kacena, Ph.D. Michaela Kneissel, Ph.D. Joanna S. Price, D.V.M., Ph.D. Andre J. Van Wijnen, Ph.D. Joy Y. Wu, M.D., Ph.D., Ad Hoc Nancy Lane, M.D., Council Liaison Earline Marshall, Staff Liaison ASBMR REPRESENTATIVES TO FASEB Elizabeth Shane, M.D. FASEB Board of Directors Ann L. Elderkin, P.A. Board of Directors, Staff Liaison Paula H. Stern, Ph.D. FASEB Advisor, Board of Directors Science Policy Committee

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Kurt D. Hankenson, DVM, Ph.D. Animals in Research and Education Issues Subcommittee, Science Policy Committee Richard S. Bockman, M.D., Ph.D Clinical Research Subcommittee, Science Policy Committee Larry J. Suva, Ph.D. International Issues Subcommittee, Peer Review Subcommittee, Science Policy Committee Nicola Partridge, Ph.D. NIH Issues Subcommittee, Science Policy Committee Larry J. Suva, Ph.D. Peer Review Subcommittee, Science Policy Committee Merry Jo Oursler, Ph.D. Training and Career Resources, Science Policy Committee Barbara E. Kream, Ph.D. Excellence in Science Award Committee Robert D. Blank, M.D., Ph.D. Research Conferences Advisory Committee Louis C. Gerstenfeld, Ph.D. FASEB Publications and Communications Committee Robert A. Fulcher FASEB Publications and Communications Committee, Staff Liaison Gloria Gronowicz, Ph.D. FASEB Federal Funding Consensus Conference Representative Bernard P. Halloran, Ph.D. FASEB Federal Funding Consensus Conference Representative John J. Wysolmerski, M.D. FASEB Editorial Board ASBMR REPRESENTATIVES TO OTHER GROUPS Sundeep Khosla, M.D. National Bone Health Alliance Ann L. Elderkin, P.A. National Bone Health Alliance, Staff Liaison Mark L. Johnson, Ph.D. National Action Plan for Bone Health Coordinating Committee Ann L. Elderkin, P.A. Douglas Fesler National Action Plan for Bone Health Coordinating Committee, Staff Liaisons Marc C. Hochberg, M.D., MPH U.S. Bone and Joint Decade Stuart L. Silverman, M.D. National Osteoporosis Foundation Interspecialty Medical Council Marjorie M. Luckey, M.D. National Osteoporosis Foundation Subcommittee on Implementation of New Guidelines for Practicing Physicians Ann L. Elderkin, P.A. National Osteoporosis Foundation Subcommittee on Implementation of New Guidelines for Practicing Physicians, Staff Liaison

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Sundeep Khosla, M.D. Sister Societies Forum Keith A. Hruska, M.D. Sister Societies Forum Ann L. Elderkin, P.A. Sister Societies Forum, Staff Liaison AWARDS WILLIAM F. NEUMAN AWARD Gerard Karsenty, M.D., Ph.D. FULLER ALBRIGHT AWARD Alexander Robling, Ph.D. FREDERIC C. BARTTER AWARD Jane Cauley, Ph.D. LOUIS V. AVIOLI FOUNDERS AWARD Roberto Pacifici, M.D. GIDEON A. RODAN EXCELLENCE IN MENTORSHIP AWARD Henry Kronenberg, M.D. LAWRENCE G. RAISZ AWARD Hiroshi Kawaguchi, M.D., Ph.D. PAULA STERN ACHIEVEMENT AWARD Marie Demay, M.D. SHIRLEY HOHL SERVICE AWARD Joan McGowan, Ph.D. ASBMR EARLY CAREER EXCELLENCE IN TEACHING AWARD Stuart Warden, Ph.D. 2011 ASBMR MOST OUTSTANDING BASIC ABSTRACT AWARD Hong Zhou, M.D., Ph.D. 2011 ASBMR MOST OUTSTANDING CLINICAL ABSTRACT AWARD Sumit R. Majumdar, M.D., MPH 2011 ASBMR PRESIDENT’S AWARD Katherine J. Motyl, Ph.D. 2011 SHUN-ICHI HARADA YOUNG INVESTIGATOR AWARD Kazuki Inoue, Ph.D. Amanda S. Carmel, M.D. Aarthi Arasu, M.D. 2011 ASBMR FELIX BRONNER YOUNG INVESTIGATOR AWARD Meghan E. McGee-Lawrence, Ph.D.

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2011 ASBMR YOUNG INVESTIGATOR AWARD RECIPIENTS Partially supported by educational grants from Lilly USA, LLC, Pfizer, Inc. and Kyowa Hakko Kirin Pharma Jee Hyun An, M.D. Olena Andrukhova, Ph.D. Anna E. Bo¨rjesson, MSc Huiling Cao, M.D., Ph.D. Aude-Helene Capietto, Pharm.D., Ph.D. Ming-Kang Chang, Ph.D. Robinder J. S. Dhillon, MBBS, MRCS, MBA Kosuke Ebina, M.D., Ph.D. Keertik Fulzele, Ph.D. Alexa E. Gallagher Alfred C. Griffin III Baosheng (Boris) Guo, Ph.D. student Erica Paige Homan Yoko Hosaka, M.D. Abdallah Husseini, M.D. Shozo Itoh, M.D. Srividhya Iyer, Ph.D. Behzad Javaheri, Ph.D. Sonia Jean, MSc, Ph.D. Shino Kondoh Maria Carolina Medina Go´mez Tomoyuki Mukai, M.D., Ph.D. Lucas E. Nikkel Yoichi Ohta, M.D., Ph.D. Satoshi Ohte, M.S. Kuniaki Ota, M.D., Ph.D. Norman K. Pollock, Ph.D. Kenneth E. S. Poole, BM, Ph.D. Atharva A. Poundarik Beth A. Prairie, M.D., MPH Leila D. Revollo Steven D. Rhodes Sandra Romero-Suarez, Ph.D. Vaibhav Saini, Ph.D. Valerie Salazar, Ph.D. Kazusa Sato, Ph.D. Jia Shen, Ph.D. Nah-Young Shin, Ph.D. Jordan Matthew Spatz Matthew Stuible, Ph.D. Jianning Tao, Ph.D. Jumpei Teramachi, D.D.S, Ph.D. Yoko Uehata, MS, RD Feng-Ming Wang, D.D.S., Ph.D. Lingling Xian, M.D., Ph.D. Guoshuang Xu, Ph.D. Shiqiao Ye, Ph.D. Ge Zhang, M.D. Xiaodong Zhou, Ph.D.

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2011 SUPPORTERS The ASBMR gratefully acknowledges the following companies for their support: DIAMOND LEVEL

GOLD LEVEL

BRONZE LEVEL

FRIEND LEVEL

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GENERAL MEETING INFORMATION ASBMR 2011 Annual Meeting Location All ASBMR sessions will take place in the San Diego Convention Center in San Diego, California, USA, unless otherwise stated. The San Diego Convention Center is located at 111 W. Harbor Drive, San Diego, CA 92101. Annual Meeting Evaluation The 2011 Annual Meeting Evaluation will be accessible online starting September 22, 2011. An email will be sent to all meeting attendees who provided their email addresses at the time of registration. The email will provide a hyperlink to the online evaluation site. It will also to be accessible via the ASBMR website at www.asbmr.org. We strongly encourage and welcome all attendees to provide us with feedback on the meeting. Your input is very important to us. Registration Hours Registration desks will be open for new registrants and material pick-up in the San Diego Convention Center Hall F during the following hours: Thursday, September 15 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12:00 pm – 6:00 pm Friday, September 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 7:00 pm Saturday, September 17. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 5:30 pm Sunday, September 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:30 am – 5:00 pm Monday, September 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:30 am – 5:00 pm Exhibit Hall Hours The Exhibit Hall is located in Hall GH. Please note that children aged 12 and under are not permitted in the exhibit hall at any time. Lunch will be available for purchase in the hall during Exhibit hours. Friday, September 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5:45 pm – 7:00 pm Saturday, September 17. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 am – 4:00 pm Sunday, September 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 am – 4:00 pm Monday, September 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:30 am – 4:30 pm ASBMR Media Office The ASBMR Media Office will be in operation to facilitate media-related activities during the meeting. The Media Office will be located in Room 28D in the San Diego Convention Center. Media Office - Hours of Operation Thursday, September 15 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2:00 pm – 5:00 pm Friday, September 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 5:00 pm Saturday, September 17. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 5:30 pm Sunday, September 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 5:30 pm Monday, September 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 5:00 pm Tuesday, September 20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 12:00 Noon ASBMR On-site Telephone Numbers Registration Desk (see hours above) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Tel: (619) 525-6245 Media Office. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Tel: (619) 525-6244 Management Office. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Tel: (619) 525-6243 Future ASBMR Annual Meeting Dates ASBMR 2012 Annual Meeting Minneapolis Convention Center, Minneapolis, Minnesota, USA October 12 – 16, 2012 ASBMR 2013 Annual Meeting Baltimore Convention Center, Baltimore, Maryland, USA October 4 – 8, 2013 ASBMR POLICIES Re-Use of ASBMR Annual Meeting Material The ASBMR Annual Meeting is held to facilitate the open, non-commercial dissemination of scientific knowledge in the bone and related fields. Material presented at the ASBMR Annual Meeting is subject to copyright or other re-use restrictions. Information about these restrictions, ASBMR policies regarding reuse of such material, and procedures for obtaining permission are detailed below.

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Abstracts Abstracts submitted to the ASBMR 2011 Annual Meeting are copyrighted by the American Society for Bone and Mineral Research and published in the JBMR. Reproduction, distribution, or transmission of the abstracts in whole or in part, by electronic, mechanical or other means, or other intended use, is prohibited without the express written permission of the American Society for Bone and Mineral Research. Information about how to obtain permission to re-use ASBMR Annual Meeting abstracts is provided below in the section entitled ‘‘Re-Use of ASBMR Annual Meeting Abstracts.’’ Other Material Information presented at the ASBMR Annual Meeting other than abstracts, including but not limited to posters, on-screen presentations (e.g. PowerPoint), and hand-outs are the intellectual property of individual presenters or organizations other than the ASBMR. Such material may not be re-used without the written consent of the relevant individual or organization and, in some cases, the ASBMR. Details are provided below in the section entitled ‘‘Re-Use of Other ASBMR Meeting Materials.’’ Re-Use of ASBMR Annual Meeting Abstracts Embargo The Abstracts On-Line, Itinerary Builder, and a printable PDF of the Abstracts book are made available to Annual Meeting attendees and to members of the ASBMR in advance but are embargoed until one hour after the time of their presentation at the Annual Meeting. The Abstracts on CD-ROM may be made available for viewing prior to presentation by written permission of the ASBMR, but contents are embargoed until one hour after the time of their presentation. ASBMR does not grant permission for reproduction or re-use of any ASBMR Annual Meeting abstract until after that abstract has been presented at the meeting. The ASBMR is sensitive to issues of commercial confidentiality and relevant aspects of the U.S. Securities and Exchange Commission (SEC) regulations. Therefore, the ASBMR reminds all readers that all must adhere to the U.S. Securities and Exchange Commission regulations and treat all scientific information as confidential until the embargo has been lifted – one hour after the abstract has been presented. Any reader of, or listener to, ASBMR Annual Meeting content may be viewed as an ‘‘insider’’ by the SEC due to knowledge of information included in abstracts, particularly clinical trial abstracts. SEC regulations may call for criminal penalties for using such information. Permission for Re-Use of Abstracts: Individuals and News Media Permission requests for individual or news media reproduction or re-use of JBMR material or for reproduction or re-use of JBMR material in a professional work (e.g., a journal or professional reference book) must be made in writing to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030 USA; fax: +1-201-748-6008; e-mail: [email protected], and should include a statement of intended use, as well as explicit specifications of the materials to be reproduced. When submitting your permission request, please include the following information: N A complete citation of the requested material (title of journal, volume number, issue number, year, author name, article or abstract title, specific page numbers, and, if applicable, abstract number) N The intended use of the material (for publication, slides, handouts, etc.) N If for handouts: the number of copies being made N If for republication: the publisher and the name of the new publication N How the material will be reproduced and distributed N Complete contact details (name, institution/company name, address, telephone, fax, email) Permission for Re-Use of Abstracts: Corporate Purposes Permission for reproduction or re-use of JBMR material, including abstracts, for corporate purposes (e.g., storage on a corporate intranet, corporately-sponsored distribution to physicians) is subject to approval by the ASBMR. Requests for commercial reprints or similar re-use of JBMR material, including abstracts, must be directed to Beth Ann Rocheleau, Reprints and Eprints Manager, Rockwater, Inc., PO Box 2211, Lexington SC 29072, USA, phone: +1-803- 359-4578; fax: +1-803-753-9430, email: [email protected]. Should ASBMR grant permission for abstract reproduction, the following must occur: A disclaimer must be prominently displayed/printed (often this appears on the inside front cover), indicating that the choice of abstracts to reproduce full-text was not made by the ASBMR. Example: Selection of abstracts was made by {company name} and does not necessarily include all abstracts presented on this subject at the 2011 Annual Meeting of the American Society for Bone and Mineral Research {San Diego, California, USA 09/16/2010 – 09/20/2011}. The compilation does not constitute an endorsement by ASBMR of the product, assay or information contained herein. No responsibility is assumed and responsibility is hereby disclaimed by the American Society for Bone and Mineral Research for any injury and/or damage to persons or property as a matter of product liability, negligence or otherwise, or from any use or operation of methods, products, instructions or ideas presented in the abstracts. Independent verification of diagnosis and drug dosages should be xvi

made. Discussions, views and recommendations as to medical procedures, choice of drugs and drug dosages are the responsibilities of the authors. Translation of Abstracts Translation of JBMR material, including abstracts, into languages other than English is subject to the approval of the ASBMR. Translations must carry the following disclaimer in English and in the language of the translation: The American Society for Bone and Mineral Research takes no responsibility for the accuracy of the translation from the published English original and is not liable for any errors which may occur. No responsibility is assumed, and responsibility is hereby disclaimed, by the American Society for Bone and Mineral Research for any injury and/or damage to persons or property as a matter of product liability, negligence or otherwise, or from any use or operation of methods, products, instructions or ideas presented in the Journal. Independent verification of diagnosis and drug dosages should be made. Discussions, views, and recommendations as to medical procedures, choice of drugs and drug dosages are the responsibility of the authors. Re-Use of Other ASBMR Annual Meeting Material Re-Use for Commercial purposes Organizations may not re-use material presented at the Annual Meeting for commercial purposes without the written consent of the presenter or other appropriate party (e.g., the copyright holder) and the ASBMR. Commercial purposes include but are not limited to symposia, educational programs, and other forms of presentation, whether developed or offered by for-profit or not-for-profit entities, and that involve funding from for-profit firms or a registration fee that is other than nominal. Questions regarding this policy or requests for re-use of Annual Meeting materials may be directed to the ASBMR Business Office at +1 (202) 367-1161 or [email protected]. Disclaimer All authored abstracts, findings, conclusions, recommendations, or oral presentations are those of the author(s) and do not reflect the views of the ASBMR or imply any endorsement. No responsibility is assumed, and responsibility is hereby disclaimed, by the American Society for Bone and Mineral Research for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of methods, products, instructions, or ideas presented in the materials herein (2011 Abstracts). Independent verification of diagnosis and drug dosages should be made. Discussions, views, and recommendations as to medical procedures, choice of drugs, and drug dosages are the responsibility of the authors. Audio and Video Recording ASBMR expects that attendees respect each presenter’s willingness to provide free exchange of scientific information without the abridgement of his or her rights or privacy and without the unauthorized copying and use of the scientific data shared during his or her presentation. In addition, ASBMR expects that attendees will respect exhibitors’ desires not to have their products or booths photographed or videorecorded. The use of cameras, audio-recording devices, and video-recording equipment is strictly prohibited within all Scientific Sessions, the Exhibit Halls, and Poster Sessions without the express written permission of both the ASBMR and the presenter/exhibitor. Unauthorized use of the recording equipment may result in the confiscation of the equipment or the individual may be asked to leave the session or Exhibit Hall. These rules are strictly enforced. Use of ASBMR Name and Logo ASBMR reserves the right to approve the use of its name in all materials disseminated to the media, public and professionals. The ASBMR name, meeting name, and meeting logo may not be used without permission. Use of the ASBMR logo is prohibited without the express written permission of the ASBMR Executive Director. All ASBMR corporate supporters and exhibitors should share their media outreach plans with the ASBMR before release. No abstract presented at the ASBMR 2011 Annual Meeting may be released to the press before its official presentation date and time. Press releases must be embargoed until one hour after the presentation. CONTINUING MEDICAL EDUCATION CREDITS Continuing Medical Education Credits This educational activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Institute for the Advancement of Human Behavior (IAHB) and the American Society for Bone and Mineral Research (ASBMR). The IAHB is accredited by the ACCME to provide continuing medical education for physicians. xvii

AMA PRA Statement The IAHB designates this educational activity for a maximum of 35.5 AMA PRA Category 1 CreditsTM Physicians should only claim credit commensurate with the extent of their participation in the activity. Online Evaluation to Receive CME The online evaluation to receive CME will be available beginning Monday, September 26. Please Note: There will be a $50 fee per application. This fee can be paid when you register for the Annual Meeting or added during the Meeting at the Registration Desk. See page xv for hours. Please note, the desk is not open on Tuesday, September 20. Should you have questions regarding the online CME evaluation, contact Jillian Davis at (651) 789-3722 or [email protected]. Meeting Objectives Upon returning home from the meeting, participants should be able to: N Identify and discuss the most current and significant advances in biomedical and clinical research in bone and mineral metabolism, specifically in the areas of muscle and bone, vitamin d, calcium supplementation, mineral metabolism, genetics, osteoporosis, musculoskeletal diseases, metabolic bone diseases and therapeutics. N Better understand the interrelationship among basic research, clinical research and patient care. N Improve their ability to treat and care for their patients through an enhanced knowledge of osteoporosis, other diseases of bone, basic bone biology and its correlation to mineral metabolism. N Develop new and enhanced strategies for the diagnosis and treatment of patients with disorders of bone and mineral metabolism. Target Audience The program is designed for researchers, physicians and other health and allied health professionals with interests in biomechanics, endocrinology, physiology, cell biology, metabolism and musculoskeletal research, pathology, molecular biology, genetics, epidemiology, internal medicine, rheumatology, orthopaedics, dentistry, nephrology, and pharmacology. ASBMR Expectations of Authors and Presenters Through ASBMR meetings, the Society promotes excellence in bone and mineral research. To that end, ASBMR expects that all authors and presenters affiliated with the ASBMR 2011 Annual Meeting and the 2011 Ancillary Program will provide informative and fully accurate content that reflects the highest level of scientific rigor and integrity. ASBMR depends upon the honesty of the authors and presenters and relies on their assertions that they have had sufficient full access to the data and are convinced of its reliability. Furthermore, ASBMR expects that: N Authors and presenters will disclose any conflicts of interest, real or perceived. N Authors of an abstract describing a study funded by an organization with a proprietary or financial interest must affirm that they had full access to all the data in the study. By so doing, they accept complete responsibility for the integrity of the data and the accuracy of the data analysis. N The content of abstracts, presentations, slides and reference materials must remain the ultimate responsibility of the author(s) or faculty. N The planning, content and execution of abstracts, speaker presentations, slides, abstracts and reference materials should be free from corporate influence, bias or control. N All authors and presenters (invited and abstracts-based oral and poster presenters) should give a balanced view of therapeutic options by providing several treatment options, whenever possible, and by always citing the best available evidence. In addition, ASBMR’s meeting evaluations will seek feedback regarding commercial bias at ASBMR Annual Meeting sessions, including the 2011 Ancillary Program. Disclosure/Conflict of Interest Statement The American Society for Bone and Mineral Research is committed to ensuring the balance, independence, objectivity and scientific rigor of all its individually sponsored or industry-supported educational activities. Accordingly, the ASBMR adheres to the requirement set by ACCME that audiences at jointly sponsored educational programs be informed of a presenter’s (speaker, faculty, author or planner) academic and professional affiliations, and the disclosure of the existence of any significant financial interest or other relationship a presenter or their spouse has with any proprietary entity over the past twelve months producing, marketing, re-selling or distributing health care goods or services, consumed by, or used on patients, with the exemption of non-profit or government organizations and non-health care related companies. When an unlabeled use of a commercial product, or an investigational use not yet approved for any purpose, is discussed during the presentation, it is required that presenters disclose that the product is not labeled for the use under discussion or that the product is still investigational. This policy allows the listener/attendee to be fully knowledgeable in evaluating the information being presented. Within this OnSite Program book it is noted those speakers who have disclosed relationships, including the nature of the relationship and the associated commercial entity. xviii

Disclosure should include any relationship that may bias one’s presentation or which, if known, could give the perception of bias. This includes relevant financial relationships of a spouse or partner. Disclosures will be printed in the program materials. These situations may include, but are not limited to: 1) Stock options or bond holdings in a for-profit corporation or self-directed pension plan; 2) Research grants; 3) Employment (full or part-time); 4) Ownership or partnership; 5) Consulting fees or other remuneration (payment); 6) Non-remunerative positions of influence such as officer, board member, trustee or public spokesperson; 7) Receipt of royalties; 8) Speaker’s bureau; 9) Other. Disclosures for invited speakers and abstract presenters are provided at the end of the session listing. The disclosure information will correspond to the key above. If disclosures are given, the company name, along with the respective disclosure relationship number will be listed (for example: Company Name 2, 8.) ANNUAL MEETING RESOURCE MATERIALS Abstracts Book The 2011 Abstracts Book is published as a supplement of the Journal of Bone and Mineral Research (JBMR). Electronic copies are available on the ASBMR website and via CD-ROM at the Materials Pick-up counter where you receive your delegate bag. Printed copies were only available for those who ordered in advance. ASBMR Abstracts Online Only members and pre-registered Annual Meeting attendees are able to access the 2011 Abstracts On-line Program. This tool can be used to help you search for and review abstract presentations, as well as plan your meeting itinerary. Abstracts on CD-ROM As a registered meeting attendee, you will have the option to receive a copy of the ASBMR 2011 Annual Meeting abstracts on CD-ROM, allowing you the ability to do customized searches and review of abstracts while at the meeting. ASBMR Annual Meeting eGuide This free smartphone application is a mobile version of the on-site program book and includes the meeting abstracts. The app also features general meeting information, exhibitor listings and detailed maps of the convention center. To download the app, go to www.skyscape.com/asbmr11 using the browser on your smartphone or mobile device. Technical support is available Friday through Sunday in the registration area in the San Diego Convention Center. Meet-the-Professor Handout Booklet The Meet-the-Professor Handout Booklet contains all the handouts supplied by the professors in one convenient booklet. Pick-up your pre-paid copy at the Materials Pick-up counter where you receive your delegate bag or to purchase onsite, inquire at the Onsite Registration desk if any additional supplies are available. Webcasting The following sessions will be recorded by ASBMR and made available at www.asbmr.org within 60 days of the Annual Meeting: N Gerald D. Aurbach Memorial Lecture – MicroRNA Control of Muscle Development and Disease, Eric Olson, Ph.D., University of Texas Southwestern Medical Center N Louis V. Avioli Lecture – Osteocytes: The Great Communicators, Lynda F. Bonewald, Ph.D., University of Missouri at Kansas City N ASBMR/ECTS Clinical Debate – ASBMR/ECTS Clinical Debate – Calcium Supplementation Is Safe and Effective N Plenary Symposium I – Muscle and Bone Interactions N Plenary Symposium II – Lipotoxicity: Bad to the Bone N Plenary Symposium III – Novel Genetic and Epigenetic Approaches to Human Disease N Clinical Roundtable/Case Conference – Anabolic Agents for Fracture Repair N Clinical Roundtable/Case Conference – Managing Musculoskeletal Disease in Chronic Renal Insufficiency N Clinical Roundtable/Case Conference – Monitoring Osteoporosis Therapy – To Scan or Not to Scan? N Clinical Update for Health Professionals N Clinical Update for Health Professionals – IOM Report on Vitamin D N Clinical Evening at ASBMR N Meeting Overview for Health Professionals

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ADDITIONAL RESOURCES ‘‘Flash’’ Discussion Areas Join your colleagues for a spontaneous ‘‘flash’’ discussion of any topic of your choosing. Are you wrestling with a problem you’d like to consult with others? Do you want to continue a discussion started in a session? Are you looking to start a debate on a controversial topic area? Look for empty Flash Discussion booths within the 100 and 500 exhibit aisles. Pick your topic area and write it on the flipchart in the booth. Tweet (@ASBMR) or post to our Facebook Fan Page (www.facebook.com/ASBMR) your location and topic so that others can join. Internet Access The ASBMR Internet Lounges located in the ASBMR Networking Center in the Exhibit Hall will be open as follows: Friday, September 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5:45 pm – 7:00 pm Saturday, September 17. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 6:00 pm Sunday, September 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 6:00 pm Monday, September 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 4:30 pm Internet access is not available in other parts of the exhibit or poster hall without a fee. However, you will be able to access the ASBMR wifi network in the ASBMR meeting space and our foyer areas. Childcare Services ASBMR makes no endorsement of any providers and accepts no liability should you employ child-care services while in San Diego. Please note: Children under 12 years of age are not permitted in any ASBMR meeting, session rooms or Exhibit/Poster Hall at any time. For more information about child care providers in San Diego, please contact your hotel concierge. Wheelchairs Scooter and wheelchair rentals are available by contacting Scootaround, Inc., at their toll-free hotline: (888) 441-7575. You can also submit a rental inquiry on the web at www.scootaround.com. Please make sure to tell them you are with the American Society for Bone and Mineral Research’s 2011 Annual Meeting in San Diego, California.

N N N N N N

Special Notices and Safety Tips Remove your convention badge outside the meeting sites. Do not wear your badge outside or advertise that you’re a visitor and not familiar with your surroundings. Walk with another person rather than alone. Avoid alleys, walkways between buildings, and deserted parking lots. Remain alert, be aware of your surroundings, and carry your handbag in front of you. While in your hotel room, always lock your door. Know where emergency exits are in your hotel. Place any valuables in a hotel safety deposit box rather than leaving them in your room or carrying them with you. Keep a copy of your passport and travel papers in a safe place.

ASBMR NETWORKING CENTER The ASBMR Networking Center provides a central gathering place for people and resources to converge in conversations and other communications. The Center is located at the base of the 300 aisle in the Exhibit Hall and provides a place to: N Check your email through either the desktop computers in the Cyber Cafe´ or on your own laptop in the WiFi Cafe N Receive guidance on navigating the conference or information on the Society in the ASBMR Membership Area N Find other Residents, Students, Fellows, or Young Investigators in the Young Investigator Lounge

N N

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Meet with National Institutes of Health (NIH) and the Center for Scientific Review (CSR) representatives Peruse available jobs and meet with prospective employers in the career center.

ASBMR Membership The ASBMR Booth will be in the Networking Center in the Exhibit Hall. Come by and meet the ASBMR staff, pick up information about the Society, check out the online version of the Journal of Bone and Mineral Research, and order copies of the 8th edition of the Primer on Metabolic Bone Diseases and Disorders of Mineral Metabolism. The ASBMR Membership Counter will be located in the ASBMR meeting registration area in Hall F of the San Diego Convention Center and will be prepared to accept 2012 ASBMR membership renewal payments. ASBMR Career Center The ASBMR Career Center Service is easily accessible year-round online. You can access the most up-todate job and candidate listings using the ASBMR Career Center Website. Simply submit your resume or job announcement using the online forms at www.asbmr.org. After your forms are submitted and payment is received, you will be able to use your self-assigned login name and password to access the Online Placement Service database anytime you wish. Employers enrolled in the service will be entitled to display unlimited job announcements online and onsite at the meeting in the ASBMR Networking Center located in the Exhibit Hall. In addition, employers will have access to candidates’ Curricula Vitae and to interview rooms. Employers and candidates may request further information by accessing the ASBMR Career Center at www.asbmr.org. Poster Tours The Annual Meeting Poster Session Tours will take place during each of the three poster sessions. These poster tours will be guided by a prominent scientist to assist attendees to navigate the science within the poster hall. Participants can choose between a tour focused on either basic or clinical science. The tours will begin at the ASBMR Networking Center located in the Exhibit Hall. Each tour will last approximately 60 minutes and will be lead by a member of the ASBMR. Tour availability will be offered on a first-come, firstserved basis – no additional charge is required. The poster tour schedule is as follows: Poster Session Poster Session I: Saturday, September 17, 2011 Poster Session II: Sunday, September 18, 2011 Poster Session III: Monday, September 19, 2011

Tour Start Time 11:30 a.m. – 12:30 p.m. 11:30 a.m. – 12:30 p.m. 12:00 noon – 1:00 p.m.

Start Location ASBMR Networking Center ASBMR Networking Center ASBMR Networking Center

NIH Lounge Representatives from the U.S. National Institutes of Health (NIH) and the Center for Scientific Review (CSR) will be in a special section of the ASBMR Networking Center to discuss grant proposals and ideas. Program staff from the following institutes and centers will be available to talk with you:

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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Cancer Institute (NCI) National Institute of Dental and Craniofacial Research (NIDCR) National Institute on Aging (NIA) National Institute of Child Health and Human Development (NICHD) Center for Scientific Review (CSR)

Young Investigator Lounge All young investigator attendees are invited to drop by the Young Investigator Lounge located in the ASBMR Networking Center in the Exhibit Hall. Don’t miss this opportunity to make new friends and expand your network of colleagues.

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INFORMATION FOR SPEAKERS AND POSTER PRESENTERS Speaker Ready Room Speakers must check into the Speaker Ready Room 24 hours in advance of their presentation. At that time, speakers may review their slides. The Speaker Ready Room is located in Room 28B in the San Diego Convention Center. Review of slides must occur at least 24 hours prior to your presentation. The Speaker Ready Room will be open during the following times: Speaker Ready Room Hours Thursday, September 15 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 am – 5:00 pm Friday, September 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 5:30 pm Saturday, September 17. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 5:30 pm Sunday, September 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 5:30 pm Monday, September 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 5:30 pm Tuesday, September 20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 11:00 am Speaker Lounge The Speaker Lounge will be located in Room 28C in the San Diego Convention Center. The lounge provides a relaxing atmosphere for the oral presenters and invited speakers to rest, mingle with one another, and to catch up on office work. The room will be equipped with computers, copier, phone lines, internet access, snacks and beverages, sofas and chairs. The Speaker Lounge will be available from Friday, September 16 to Monday, September 19, from 7:00 am to 4:00 pm. Poster Sessions All poster sessions will be held in Hall GH in the San Diego Convention Center. Authors must be at their posters for the designated poster sessions on Saturday through Monday and must be available to answer questions during this period. Please adhere to the presentation times to maximize interaction with other attendees. Presenters should mount their posters on the board bearing their assigned numbers, disregarding the letter prefix. ASBMR accepts no liability for posters or poster materials and will not adjudicate disputes between abstract presenters. Please note that children 12 years of age and under will not be permitted in the poster area or the Exhibit Hall at any time. Presenter Check-in: Since only poster presenters are allowed in the Exhibit/Poster Hall during the below poster set-up and dismantle hours, please go to the Poster Presenter Check-in Table at the entrance door to Hall G on the lobby level of the San Diego Convention Center to receive a security pass. To speed the check-in process, please have your poster board number ready. N NOTE: Posters remaining after Poster Dismantling times will be discarded.

N

Young Investigator Award Posters remain up through Monday, September 19 at 4:30 pm.

Please adhere to these scheduled times to maximize interaction for other attendees: POSTER SESSION PRESENTATION SCHEDULE Poster Set-Up Posters Open Authors Present Friday, Sept.16 Welcome Reception/Plenary Poster Session 3:00 pm – 4:45 pm 5:45 pm – 7:00 pm 5:45 pm – 7:00 pm Plenary Posters & Young Investigator Award Posters ONLY Saturday, Sept. 17 Poster Session I 7:30 am – 8:00 am 8:00 am – 6:00 pm 11:00 a.m. – 1:00 p.m. (Includes plenary and Saturday poster presenters) Sunday, Sept. 18 Poster Session II 7:30 am – 8:00 am 8:00 am – 6:00 pm 11:00 a.m. – 1:00 p.m. (All Sunday poster presenters) Monday, Sept. 19 Poster Session III 7:30 am – 8:00 am 8:00 am – 4:30 pm 11:30 a.m. – 1:30 p.m. (All Monday poster presenters)

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Dismantle Posters Do not dismantle

6:00 pm – 6:30 pm Saturday Posters Plenary Posters 6:00 pm – 6:30 pm Sunday Posters 4:30 pm – 5:00 pm Monday Posters Young Investigator Award Posters

HOW THE PROGRAM WAS SELECTED SIMPLY MARVELOUS!! In this space, the ASBMR President traditionally discusses ‘‘how the program was selected,’’ but the truth is that I am really not sure how to describe the process. Thus, rather than being disingenuous, I just put down the first words that came to mind when I thought about both the process and (at the risk of considerable immodesty) the final product that is the 2011 ASBMR Program in San Diego. That said, I will attempt to describe The Team, The Program, and what I hope my thoughts and feelings will be on The Trip Home. The Team Casting aside all modesty, this was simply marvelous! The Team consisted of Suzanne Jan de Beur (Clinical Chair), Dwight Towler (Basic Science Chair), and me (role somewhat unclear). The three of us were guided by the watchful eyes and precocious wisdom of Angela Cangemi and Adair Landy (the superb staff liaisons to the Program Committee). I will free associate in describing my co-chairs: Suzanne – incredible breadth of knowledge, from basic to clinical; unbridled enthusiasm; and a remarkable ability to multi-task; Dwight – encyclopedic brilliance; attention to details I did not even know existed; and a capacity for work that was exhausting even to watch. The Program This, I hope, will be simply marvelous! While diverse in terms of covering the breadth of research in our field, the program committee took to heart the decision of Council to try to expand the reach of our Society into tissues interacting with bone. Thus, an underlying Theme of the Program is ‘‘Bone and Muscle.’’ This starts with the first Plenary Symposium entitled ‘‘Muscle and Bone Interactions’’, which is dedicated to the 25th Anniversary of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and features an overview by Dr. Stephen Katz, Director of NIAMS, of musculoskeletal research supported by NIAMS. Continuing this Theme is the Gerald D. Aurbach Lecture, given this year by Dr. Eric Olson (‘‘MicroRNA Control of Muscle Development’’), as well as the Louis V. Avioli lecture, given by Dr. Lynda Bonewald (‘‘Osteocytes – The Great Communicators’’). The Bone-Muscle Theme is rounded out by the clinical symposium on ‘‘Controversies and Concepts in Musculoskeletal Frailty’’ and the Clinical Roundtable on ‘‘Managing Musculoskeletal Disease in Chronic Renal Insufficiency.’’ The rest of the program is equally compelling, covering diverse areas such as new concepts in bone remodeling, bone-hematopoietic interactions, epigenetics, lipotoxicity and bone, osteoblast/osteoclast coupling, autophagy, and TRP channels. There will, I’m sure, be a healthy debate on calcium supplementation and an energetic discussion (with plenty of time for audience participation) of the IOM Report on Vitamin D. Additional clinical roundtables include a discussion of anabolic agents for fracture repair, issues surrounding DXA monitoring of patients on treatment, and a Clinical Update for Health Professionals featuring three very practical and clinically relevant topics. Finally, the ASBMR Task Force on Systems Approaches to Secondary Fracture Prevention will present their findings. A new feature of this year’s program is the ‘‘Clinical Evening at ASBMR’’ on Saturday, which replaces the traditional industry-sponsored symposia. This session is supported by multiple companies but constructed by the ASBMR Program Committee. It will include a wine and cheese reception followed by three talks of interest to clinicians over dinner, with the session ending in time for attendees to enjoy the Social Event. The Trip Home As I write this, months before the Annual Meeting, I am already thinking about the flight home from San Diego to Lake Wobegon (yes – Rochester, Minnesota, does have a lake, and at least some of the local inhabitants are partial to lutefisk). I know I will be exhausted, but hopefully in a good way. While there will be numerous metrics and surveys by which to judge the success (or failure) of this meeting, my hope is that each attendee will, during the trip home, feel that this was time and money well spent. Specifically, that the meeting was intellectually stimulating, provided new ideas to pursue, and that the discourse was vigorous, perhaps even entertaining, but never acrimonious. These are the metrics that matter most to me, and I hope I can nap in satisfaction (even in coach) on the trip home. See you all in San Diego, and if you actually made it through this rambling discourse, be sure to give me a ‘‘thumbs up’’ when we meet (whether you liked what I wrote or not . . .). Best wishes,

Sundeep Khosla, M.D. ASBMR President xxiii

Thursday, September 15, 2011

ASBMR REGISTRATION OPEN 12:00 pm - 6:00 pm

Hall F

1

Friday, September 16, 2011

FRIDAY, SEPTEMBER 16, 2011 DAY-AT-A-GLANCE Time/Event/Location

All locations in the San Diego Convention Center unless otherwise noted

7:00 am - 7:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 ASBMR Registration Open Hall F 8:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Plenary Symposium I - Muscle and Bone Interactions Room 20BCD 11:00 am - 12:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Meet-the-Professor Sessions Room 24A - Room 27A 11:00 am - 12:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Regulatory Opportunities and Challenges in Osteoporosis Room 20A 11:00 am - 12:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Meeting Overview for Health Professionals Room 31ABC 11:00 am - 12:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Grant-Writing Workshop: Navigating the NIH Resubmission Process Room 30CDE 12:00 pm - 1:30 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Symposium – Osteoblast/Osteoclast Coupling Room 20A 12:00 pm - 1:30 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Symposium - Controversies and Concepts in Musculoskeletal Frailty Room 20BCD 1:45 pm - 3:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Symposium - Autophagy in Bone Health and Disease Room 20A 1:45 pm - 3:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Symposium - Systems Approaches to Secondary Fracture Prevention: Doing Something that Actually Works Room 20BCD 3:15 pm - 3:20 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Welcome & Announcements Room 20BCD 3:20 pm - 3:25 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Presentation of the ASBMR Louis V. Avioli Memorial Founders Award Room 20BCD 3:25 pm - 3:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Presentation of the ASBMR William F. Neuman Award Room 20BCD 3:30 pm - 4:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 ASBMR/ECTS Clinical Debate - Calcium Supplementation is Safe and Effective Room 20BCD

2

3:30 pm - 5:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 State-of-the-Art Lectures – New Concepts in Bone Remodeling Room 20A 5:00 pm - 5:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Oral Poster Session: Diabetes and Bone as an Endocrine Organ Room 20A 5:00 pm - 5:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Oral Poster Session: Vitamin D and Muscle and Bone Room 20BCD 5:00 pm - 5:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Oral Poster Session: Vascular Calcification and Renal Bone Room 30CDE 5:00 pm - 5:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Oral Poster Session: Osteoarthritis and Mechanotransduction Room 31ABC

5:45 pm - 7:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Welcome Reception & Plenary Poster Session Hall GH 5:45 pm - 7:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Minority Investigator Reception Hall GH 5:45 pm - 7:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 New Investigator/New Member/First Time Attendee Reception Hall GH 7:00 pm - 8:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Young Investigator/Minority Investigator Networking Hour Center Terrace 7:15 pm - 9:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Pediatric Bone and Mineral Working Group Room 33ABC Ticket Required 7:15 pm - 9:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Working Group on Skeletal Aging Room 30AB Ticket Required 7:15 pm - 9:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 In Vivo Working Group Room 30CDE Ticket Required 7:15 pm - 9:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Muscle and Bone Working Group Room 32AB Ticket Required

3

Friday

5:45 pm - 7:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Posters and Exhibits Open Hall GH

ASBMR REGISTRATION OPEN 7:00 am - 7:00 pm

Hall F

PLENARY SYMPOSIUM I - MUSCLE AND BONE INTERACTIONS Supported by an Educational Grant from Merck & Co., Inc. 8:30 am - 11:00 am

Room 20BCD

Chair Suzanne M. Jan De Beur, M.D. Johns Hopkins University, USA Disclosures: Suzanne Jan De Beur, None

8:45 am

Introduction Stephen Katz, M.D., Ph.D. National Institutes of Health, USA Disclosures: Stephen Katz, None

9:00 am

The Growth Hormone/IGF-1 Axis in Skeletal Muscle Thomas L. Clemens, Ph.D. Johns Hopkins University, USA Disclosures: Thomas Clemens, None

9:30 am

Mitochondrial Biogenesis and Function in Aging, Obesity, and Muscle Cell Physiology Gerald Shulman, M.D., Ph.D. Howard Hughes Medical Institute Yale Medical School, USA Disclosures: Gerald Shulman, None

10:00 am Myokines: Key Regulators of the Muscle-Bone Unit Mark W. Hamrick, Ph.D. Georgia Health Sciences University, USA Disclosures: Mark Hamrick, None

10:30 am Androgen Biology in Musculoskeletal Health and Frailty Shalender Bhasin, M.D. Boston University School of Medicine, USA Disclosures: Shalender Bhasin, None

MEET-THE-PROFESSOR SESSIONS 11:00 am - 12:00 pm

Rooms 24A-27A

Hypophosphatasia and Mechanisms of Biomineralization Room 24A Michael P. Whyte, M.D. Shriners Hospital for Children, USA Disclosures: Michael Whyte, None

Jose Luis Millan, Ph.D. Sanford-Burnham Medical Research Institute, USA Disclosures: Jose Luis Millan, Enobia Pharma 5

Angiogenesis and Bone: Lessons from Genetically Modified Mouse Models Room 24B Christa Maes, Ph.D. Laboratory of Experimental Medicine and Endocrinology, K.U.Leuven, Belgium Disclosures: Christa Maes, None

Progenitor Cells in the Biology of Ossification Room 24C Eileen M. Shore, Ph.D. University of Pennsylvania, USA Disclosures: Eileen Shore, None

4

Nephrolithiasis Room 25A Murray J. Favus, M.D. University of Chicago, USA Disclosures: Murray Favus, Litholink INC. 99

Paget’s Disease Room 25B G. David Roodman, M.D., Ph.D. VA Pittsburgh Healthcare System, USA Disclosures: G. David Roodman, None

Clinical Evaluation of High Bone Mass Room 25C Michael J. Econs, M.D. Indiana University School of Medicine, USA Disclosures: Michael Econs, None

Friday

Molecular Mechanisms of Mechanosensation in Bone Room 27A Randall L. Duncan, Ph.D. University of Delaware, USA Disclosures: Randall Duncan, None

REGULATORY OPPORTUNITIES AND CHALLENGES IN OSTEOPOROSIS 11:00 am - 12:00 pm

Room 20A

Chair Gayle E. Lester, Ph.D. National Institute of Arthritis, Musculoskeletal & Skin Disease, USA Disclosures: Gayle Lester, None

11:00 am FDA Perspective, FDA Priorities, and Overall Directions Theresa E. Kehoe, M.D. CDER, FDA, USA Disclosures: Theresa Kehoe, None

11:20 am Industry Perspective Javier A. San Martin, M.D. Disclosures: Javier San Martin, None

11:40 am Panel Discussion

MEETING OVERVIEW FOR HEALTH PROFESSIONALS 11:00 am - 12:00 pm

Room 31ABC

This special session is of interest to all health professionals, first-time meeting attendees, young investigators, individuals new to the field, nurses, clinical research study coordinators, physical therapists and/or those seeking guidance in navigating through the extensive ASBMR program. Co-Chairs Diane C. Krueger, CCRC, CDT University of Wisconsin, Madison, USA Disclosures: Diane Krueger, None

Betsy McClung, R.N., M.N. Oregon Osteoporosis Center, USA Disclosures: Betsy McClung, None

5

11:00 am Basic Science Overview Roland Baron, D.D.S., Ph.D. Harvard School of Medicine and of Dental Medicine, USA Disclosures: Roland Baron, None

11:30 am Clinical Science Overview John Bilezikian, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: John Bilezikian, None

GRANT-WRITING WORKSHOP: NAVIGATING THE NIH RESUBMISSION PROCESS Co-sponsored by the ASBMR Membership Development and Education Committees 11:00 am - 12:00 pm

Room 30CDE

Recent changes to the U.S. National Institutes of Health grant application guidelines now allow for only one resubmission of a grant proposal. After that, proposals not funded must be substantially "redesigned" rather than simply changed in response to previous reviews and submitted as a new grant proposal. U.S. and international investigators at all career levels are urged to attend this interactive forum that will include an "insider’s perspective" on winning strategies to utilize when resubmitting an NIH grant, as well as guidance on what one should consider when "redesigning" their proposal. This session is a can’t miss opportunity for anyone writing a research grant or wanting to gain invaluable insight into the grant-writing process. Co-Chairs Marian T. Hannan, DSc, MPH HSL Institute for Aging Research and Harvard Medical School, USA Disclosures: Marian Hannan, None

Wenhan Chang, Ph.D. University of California, San Francisco, USA Disclosures: Wenhan Chang, None

11:00 am Strategies for Successfully Resubmitting Your NIH Grant Proposal Jay Magaziner, Ph.D. University of Maryland, Baltimore, USA Disclosures: Jay Magaziner, None

11:20 am Demystifying the NIH Rules on ‘‘Re-designed’’ Grant Proposals Joan A. McGowan, Ph.D. National Institute of Arthritis, Musculoskeletal & Skin Disease, USA Disclosures: Joan McGowan, None

11:40 am Panel Discussion Lynda F. Bonewald, Ph.D. University of Missouri - Kansas City, USA Disclosures: Lynda Bonewald, None

Jennifer J. Westendorf, Ph.D. Mayo Clinic, USA Disclosures: Jennifer Westendorf, None

SYMPOSIUM – OSTEOBLAST/OSTEOCLAST COUPLING Supported by an Educational Grant from Lilly USA, LLC 12:00 pm - 1:30 pm Co-Chairs Deborah V. Novack, M.D., Ph.D. Washington University in St. Louis School of Medicine, USA Disclosures: Deborah Novack, Enobia 5

6

Room 20A

Laurie K. McCauley, D.D.S., Ph.D. University of Michigan, School of Dentistry, USA Disclosures: Laurie McCauley, Amgen 5; Centocor 2; Amgen 1

12:00 pm Matricrine Coupling of Bone Resorption and Formation Xu Cao, Ph.D. Johns Hopkins University, USA Disclosures: Xu Cao, None

12:30 pm Osteoclast Control of Osteoblast-Mediated Bone Formation Merry Jo Oursler, Ph.D. Mayo Clinic, USA Disclosures: Merry Jo Oursler, None

1:00 pm

Coupling Factors: Lessons from Ephs and Ephrins Koichi Matsuo, M.D., Ph.D. School of Medicine, Keio University, Japan Disclosures: Koichi Matsuo, None

12:00 pm - 1:30 pm

Room 20BCD

Co-Chairs Susan L. Greenspan, M.D. University of Pittsburgh, USA Disclosures: Susan Greenspan, Merck, Amgen 5; Eli Lilly 2; Warner Chilcott 2; Tarsa Therapeutics 2

Douglas P. Kiel, M.D., MPH Hebrew SeniorLife, USA Disclosures: Douglas Kiel, Amgen 5; Merck 2; Amgen 2; Lilly 5; Novartis 5; Merck 5

12:00 pm Definition of Sarcopenia and Frailty Stephanie Studenski, M.D., MPH VA Pittsburgh Healthcare System, USA Disclosures: Stephanie Studenski, None

12:30 pm Predicting Fall Risks by Using Dynamic Assessments Kenton R. Kaufman, Ph.D., P.E. Mayo Clinic, USA Disclosures: Kenton Kaufman, None

1:00 pm

Nonpharmocologic Approaches to Reversing Sarcopenia Wendy M. Kohrt, Ph.D. University of Colorado Denver, USA Disclosures: Wendy Kohrt, None

SYMPOSIUM - AUTOPHAGY IN BONE HEALTH AND DISEASE 1:45 pm - 3:15 pm

Room 20A

Co-Chairs Lynne J. Hocking, Ph.D. University of Aberdeen, United Kingdom Disclosures: Lynne Hocking, None

Steven L Teitelbaum, M.D. Washington University in St. Louis School of Medicine, USA Disclosures: Steven Teitelbaum, None

1:45 pm

Autophagy and Its Regulation and Relevance to Musculoskeletal Health and Frailty Chris Weihl, M.D., Ph.D. Washington University in St. Louis, USA Disclosures: Chris Weihl, Link Medicine 5

7

Friday

SYMPOSIUM - CONTROVERSIES AND CONCEPTS IN MUSCULOSKELETAL FRAILTY

2:15 pm

Role of Autophagy in Disorders of Osteoclast Dysfunction Miep H. Helfrich, Ph.D. University of Aberdeen, United Kingdom Disclosures: Miep Helfrich, None

2:45 pm

Autophagy in Osteoblast Function Caroline Alicia Whitehouse, Ph.D. King’s College London, United Kingdom Disclosures: Caroline Whitehouse, None

SYMPOSIUM - SYSTEMS APPROACHES TO SECONDARY FRACTURE PREVENTION: DOING SOMETHING THAT ACTUALLY WORKS 1:45 pm - 3:15 pm

Room 20BCD

Co-Chairs John A. Eisman, MBBS, Ph.D. Garvan Institute of Medical Research, Australia Disclosures: John Eisman, None

Ethel S. Siris, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Ethel Siris, Merck 5; Amgen 8; Amgen 5; Pfizer 5; Eli Lilly 8; Eli Lilly 5

1:45 pm

The Glasgow UK Experiment: What a Working System Can Deliver Alastair R. McLellan, M.D., MBChB Western Infirmary, United Kingdom Disclosures: Alastair McLellan, AMGEN 8

2:00 pm

The China Syndrome Edith Lau, M.D. Hong Kong Orthopaedic and Osteoporosis Center for Treatment and Research, Hong Kong Disclosures: Edith Lau, None

2:15 pm

Kaiser and Enlightened Self-Interest Richard Dell, M.D. Kaiser, USA Disclosures: Richard Dell, None

2:30 pm

The Five P’s: Aligning the Interests of Patients, Physicians, Politicians, Pharmaceutical Companies & Third-party Payers Paul James Mitchell, BSc University of Derby, United Kingdom Disclosures: Paul Mitchell, Amgen 5; GlaxoSmithKline 5; Novartis 5; Novartis 8; Daiichi Sankyo UK Ltd 5

2:45 pm

Panel Discussion

WELCOME & ANNOUNCEMENTS 3:15 pm - 3:20 pm

Room 20BCD

PRESENTATION OF THE ASBMR LOUIS V. AVIOLI MEMORIAL FOUNDERS AWARD 3:20 pm - 3:25 pm

Room 20BCD

PRESENTATION OF THE ASBMR WILLIAM F. NEUMAN AWARD 3:25 pm - 3:30 pm

8

Room 20BCD

ASBMR/ECTS CLINICAL DEBATE - CALCIUM SUPPLEMENTATION IS SAFE AND EFFECTIVE 3:30 pm - 4:30 pm

Room 20BCD

Co-Chairs Juliet E. Compston, M.D., FRCP University of Cambridge School of Clinical Medicine, United Kingdom Disclosures: Juliet Compston, None

Robert A. Adler, M.D. McGuire VA Medical Center, USA Disclosures: Robert Adler, None

3:30 pm

Against Calcium Supplementation Roger Michael Francis, M.D. Institute for Ageing and Health,Newcastle University, United Kingdom Disclosures: Roger Francis, Eli Lilly 8; Servier 5; Amgen/GSK 8; Servier 8; Shire 8

4:00 pm

Friday

Pro Calcium Supplementation Richard L. Prince, FRACP, M.D. Sir Charles Gairdner Hospital, Australia Disclosures: Richard Prince, Amgen 8; Servier 2; Amgen 2; MSD 5

STATE-OF-THE-ART LECTURES – NEW CONCEPTS IN BONE REMODELING Supported by an Educational Grant from Lilly USA, LLC 3:30 pm - 5:00 pm

Room 20A

Co-Chairs Erik Fink Eriksen, M.D., DMSc Oslo University Hospital, Norway Disclosures: Erik Fink Eriksen, None

Thomas John Martin, M.D., DSc St. Vincent’s Institute of Medical Research, Australia Disclosures: Thomas John Martin, None

3:30 pm

Overview of Bone Remodeling David W. Dempster, Ph.D. Columbia University, USA Disclosures: David Dempster, Eli Lilly 8; Eli Lilly 5; Merck 5; Amgen 8; Eli Lilly 2; Amgen 5

4:00 pm

Bone Remodeling Compartment in Humans Thomas Levin Andersen, M.S. Vejle Hospital, IRS-CSFU, University of Southern Denmark, Denmark Disclosures: Thomas Andersen, None

4:30 pm

Osteomac Canopy in Mice Allison R. Pettit, Ph.D. The University of Queensland, Australia Disclosures: Allison Pettit, None

ORAL POSTER SESSION: DIABETES AND BONE AS AN ENDOCRINE ORGAN 5:00 pm - 5:45 pm

Room 20A

Moderators: Beata Anna Lecka-Czernik, Ph.D. University of Toledo College of Medicine, USA Disclosures: Beata Lecka-Czernik, None

9

Stavroula Kousteni, Ph.D. Columbia University Medical Center, USA Disclosures: Stavroula Kousteni, None

5:05 pm FR0209

Intermittent Injections of Osteocalcin Improve Glucose Metabolism and Prevent Type 2 Diabetes In Mice Mathieu Ferron*1, Marc McKee2, Patricia Ducy1, Gerard Karsenty1. 1Columbia University, USA, 2McGill University, Canada Disclosures: Mathieu Ferron, None

5:10 pm FR0394

Circulating Sclerostin Levels and Bone Turnover in Type 1 and 2 Diabetes Ranuccio Nuti*1, Roberto Valenti2, Daniela Merlotti1, Elena Ceccarelli3, Martina Ruvio3, Maria Giulia Pietrini3, Cosimo Capodarca 3, Maria Beatrice Franci3, Anna Calabro`3, Konstantinos Stolakis3, Francesco Dotta3, Luigi Gennari1. 1University of Siena, Italy, 2S. Maria Alle Scotte Hospital, Italy, 3Dept. Internal Medicine Endocrine Metabolic Sciences & Biochemistry University of Siena, Italy Disclosures: Ranuccio Nuti, None

5:15 pm FR0061

Women with Type 2 Diabetes Have Increased Femoral Neck BMD but Not Increased Femoral Strength Dana Carpenter*1, Joyce Keyak2, Janina Patsch2, Paran Yap2, Thomas Baum2, Ann Schwartz 1, Thomas Lang2, Thomas Link2. 1University of California, San Francisco, USA, 2 University of California, USA Disclosures: Dana Carpenter, None

5:25 pm FR0049

Non-Invasive Assessment of Bone Marrow Lipids Captures Fracture Risk Profile of Postmenopausal Women Irrespective of Diabetes History Janina Patsch*1, Thomas Baum2, Paran S. Yap2, Xiaojuan Li2, Dimitrios Karampinos 2, Sharmila Majumdar2, Ann Schwartz2, Thomas M. Link2. 1UCSF, USA, 2University of California, San Francisco, USA Disclosures: Janina Patsch, None

5:30 pm FR0319

Evidence that Osteocytes Elaborate Endocrine Regulation of Internal Organs Size: Data From the Osteocytes IGF-I Conditional Knockout Mice Xiaodong Zhou*1, Kin-Hing William Lau2, Lynda Bonewald3, David Baylink1, Matilda Sheng1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3University of Missouri - Kansas City, USA Disclosures: Xiaodong Zhou, None

5:35 pm FR0003

Insulin Signaling in Bone Favors Male Fertility Franck Oury*, Tatsuya Yoshizawa, Mathieu Ferron, Patricia Ducy, Gerard Karsenty. Columbia University, USA Disclosures: Franck Oury, None

ORAL POSTER SESSION: VITAMIN D AND MUSCLE AND BONE 5:00 pm - 5:45 pm

Room 20BCD

Moderators: J. Wesley Pike, Ph.D. University of Wisconsin-Madison, USA Disclosures: J. Pike, None

David Goltzman, M.D. McGill University Health Centre, Canada Disclosures: David Goltzman, None

5:05 pm FR0235

Vitamin D Signaling in Osteoblasts/Osteocytes Is Required to Shift Calcium from Bone to Serum Liesbet Lieben*1, Karen Moermans1, Lynda Bonewald2, Jian Feng3, Geert Carmeliet1. 1 Katholieke Universiteit Leuven, Belgium, 2University of Missouri - Kansas City, USA, 3 Texas A&M Health Science Center, USA Disclosures: Liesbet Lieben, None

10

5:10 pm FR0493

Enhanced Vitamin D Synthesis in Osteoblasts Protects Against Age-Related Bone Loss Paul Anderson*1, Andrew Turner2, Rebecca Sawyer1, Peter O’Loughlin3, Gerald Atkins4, Howard Morris2. 1Musculoskeletal Biology Research, University of South Australia, Australia, 2SA Pathology, Australia, 3Chemical Pathology, SA Pathology, Australia, 4 University of Adelaide, Australia Disclosures: Paul Anderson, None

5:15 pm FR0492

DNA Methylation Levels of CYP2R1 and CYP24A1 Predict Vitamin D Dose-response Variation Xiaojing Xu*1, Yu Zhou2, Fengxiao Bu2, An Ye 1, Boting Zhou1, Robert Recker1, Joan Lappe1, Lanjuan Zhao3. 1Creighton University Osteoporosis Research Center, USA, 2 Creighton University, USA, 3Creighton University Medical Center, USA Disclosures: Xiaojing Xu, None

5:25 pm FR0011

Lean Mass and the Longitudinal Probability of Mobility Disability in the Framingham Study: A Multinomial Approach for Studies of Aging Robert McLean*1, Elizabeth Newton2, Alyssa Dufour2, Joanne Murabito3, Marian Hannan4, Douglas Kiel2. 1Hebrew SeniorLife, Harvard Medical School, USA, 2Hebrew SeniorLife, USA, 3Framingham Heart Study & Boston University, USA, 4HSL Institute for Aging Research & Harvard Medical School, USA Disclosures: Robert McLean, None

Trunk Muscle Fat Infiltration is Greater in Women than Men and Increases with Age Dennis Anderson*1, John D’Agostino1, Alexander Bruno2, Douglas Kiel3, Mary Bouxsein 1. 1Beth Israel Deaconess Medical Center, USA, 2Stony Brook University, USA, 3 Hebrew SeniorLife, USA Disclosures: Dennis Anderson, None

5:35 pm FR0357

Muscle Density, a Surrogate of Intermuscular Adiposity Derived from pQCT, Is an Independent Correlate of Fractures in Women Andy Kin On Wong*1, Aakash Bhargava1, Karen Beattie1, Christopher Gordon1, Laura Pickard1, Colin Webber2, Alexandra Papaioannou 2, Jonathan Adachi3. 1McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3St. Joseph’s Hospital, Canada Disclosures: Andy Kin On Wong, None

ORAL POSTER SESSION: VASCULAR CALCIFICATION AND RENAL BONE 5:00 pm - 5:45 pm

Room 30CDE

Moderators: Keith Hruska, M.D. Washington University in St. Louis School of Medicine, USA Disclosures: Keith Hruska, None

Dolores Shoback, M.D. UCSF/VA Medical Center, USA Disclosures: Dolores Shoback, None

5:05 pm FR0186

PHOSPHO1: a Novel Therapeutic Target for Medial Vascular Calcification Tina Kiffer-Moreira*1, Manisha C. Yadav1, Dongxing Zhu2, Yalda Bravo3, Russell Dahl3, Sonoko Narisawa1, Boguslaw Stec1, Vicky E. MacRae2, Colin Farquharson 4, Jose´ Luis Milla´n 1. 1Sanford Children’s Health Research Center, Sanford-Burnham Medical Research Institute, USA, 2The Roslin Institute, The University of Edinburgh, United Kingdom, 3 Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, USA, 4The Roslin Institute, The University of Edinburgh, USA Disclosures: Tina Kiffer-Moreira, None

5:10 pm FR0160

Unique Contributions of Endothelial vs. Smooth Muscle Msx Gene Expression In Arteriosclerotic LDLR-Deficient Mice Jian Su Shao1, Su-Li Cheng2, Abraham Behrmann1, Kathryn Distelhorst1, Linda Halstead1, Robert Maxson3, Dwight Towler*1. 1Washington University in St. Louis, USA, 2Washington University in St. Louis School of Medicine, USA, 3University of Southern California, USA Disclosures: Dwight Towler, None

11

Friday

5:30 pm FR0013

5:15 pm FR0383

QCT vBMD and Vascular and Valvular Calcification: The Framingham Study Elizabeth Samelson*1, Christopher O’Donnell2, Kerry Broe3, Udo Hoffmann4, Sekar Kathiresan2, Serkalem Demissie5, L. Adrienne Cupples5, Mary Bouxsein 6, Douglas Kiel7. 1 Hebrew SeniorLife, Harvard Medical School, USA, 2National Heart, Lung & Blood Institute’s Framingham Heart Study, USA, 3Hebrew Senior Life, USA, 4Massachusetts General Hospital, USA, 5Department of Biostatistics, Boston University School of Public Health, USA, 6Beth Israel Deaconess Medical Center, USA, 7Hebrew SeniorLife, USA Disclosures: Elizabeth Samelson, None

5:25 pm FR0177

High Turnover Renal Osteodystrophy is Associated with b-Catenin Repression in Osteocytes Yves Sabbagh*, Wen Tang, Christina Bracken, Stephen O’Brien, Lucy Phillips, Sue Ryan, Shiguang Liu, Susan Schiavi. Genzyme Corporation, USA Disclosures: Yves Sabbagh, Genzyme Corporation, 3

5:30 pm FR0063

Development and Validation of a Mouse Model of Adynamic Bone Disease (ABD) Adeline Ng*1, Benjamin Alman2, Marc Grynpas3. 1University of Toronto Samuel Lunenfeld Research Institute, Canada, 2Sick Children’s Hospital, Canada, 3Samuel Lunenfeld Research Institute, Canada Disclosures: Adeline Ng, None

5:35 pm FR0120

Fgf23 Regulates Calcium and Sodium Reabsorption in Renal Distal Tubules through SGK1 Signaling Olena Andrukhova*1, Carmen Streicher2, Ute Zeitz2, Beate Lanske3, Reinhold Erben2. 1 Inst. of Physiology, Pathophysiology & Biophysics, Austria, 2University of Veterinary Medicine, Austria, 3Harvard School of Dental Medicine, USA Disclosures: Olena Andrukhova, None

ORAL POSTER SESSION: OSTEOARTHRITIS AND MECHANOTRANSDUCTION 5:00 pm - 5:45 pm

Room 31ABC

Moderators: Marc C. Hochberg, M.D., MPH University of Maryland School of Medicine, USA Disclosures: Marc Hochberg, None

David B. Burr, Ph.D. Indiana University School of Medicine, USA Disclosures: David Burr, None

5:05 pm FR0087

Disruption of Mitogen Inducible Gene 6 (MIG6) in the Mouse Genome Accelerates Surgical Induced Osteoarthritis and Down Regulates Wnt Signaling Danese Joiner*1, Michael Morris2, Donald Scholten2, Ben Staal3, George Vande Woude3, Clifford Jones4, Debra Sietsema4, Yu-Wen Zhang3, Jim Mason5. 1Van Andel Research Institute, USA, 2Orthopaedic Cell & Tissue Mechanics Laboratory, Van Andel Research Institute, USA, 3Molecular Oncology Laboratory, Van Andel Research Institute, USA, 4 Orthopaedic Associates of Michigan, USA, 5Van Andel Institute, USA Disclosures: Danese Joiner, None

5:10 pm FR0233

R-spondin 2 is a New Key Player in Human Osteoarthritis Osteoblasts to Orchestrate Their Abnormal Canonical Wnt Signaling Elie Abed*1, Thomas Chan1, Aline Delalandre 1, Johanne Martel-Pelletier 1, Jean-Pierre Pelletier1, Daniel Lajeunesse2. 1CHUM, Hoˆpital Notre-Dame, Canada, 2CRCHUM, Hoˆpital Notre-Dame, Canada Disclosures: Elie Abed, None

5:15 pm FR0157

A Novel Mouse Model of Tibial Pseudarthrosis Featuring Localized Double Inactivationof the Nf1 Gene Aaron Schindeler* 1, Jad El-Hoss2, Kate Sullivan1, Tegan Cheng1, Kathy Mikulec1, Lauren Peacock1, Paul Baldock3, Ian Alexander4, David Little 1. 1The Children’s Hospital at Westmead, Australia, 2University of Sydney, Australia, 3Garvan Institute of Medical Research, Australia, 4Children’s Medical Research Institute, Australia Disclosures: Aaron Schindeler, Celgene Inc, 2

12

5:25 pm FR0073

Mechanical Loading Activates Integrin a5b1 Leading to the Opening of Connexin 43 Hemichannels in Osteocytes - a Mechanism for Extracellular Release of Small Bone Anabolic Factors Nidhi Batra1, Sirisha Burra 2, Sumin Gu2, Xuechun Xia 3, Lynda Bonewald4, Eugene Sprague2, Martin Schwartz5, Jean Jiang*6. 1University of Texas Health Science Center at San Antonio (UTHSCSA), USA, 2University of Texas Health Science Center, USA, 3 University of Florida, USA, 4University of Missouri - Kansas City, USA, 5University of Virginia, USA, 6University of Texas Health Science Center at San Antonio, USA Disclosures: Jean Jiang, None

5:30 pm FR0092

TGFb and Substrate Stiffness Interact to Direct Chondrocyte Differentiation Jessica Orr*1, Tamara Alliston2. 1University of California - San Francisco, USA, 2 University of California, San Francisco, USA Disclosures: Jessica Orr, None

5:35 pm FR0115

Temporal Analysis of mechanical force-induced bone formation Using Quantitative Proteomics based on 8 plex- iTRAQ Wei-Bing Zhang*1, Wei-Jie Zhong2, Lin Wang2. 1Nanjing Medical University, Chn, 2 Nanjing Medical University, China Disclosures: Wei-Bing Zhang, None

5:45 pm - 7:00 pm

Hall GH

WELCOME RECEPTION & PLENARY POSTER SESSION 5:45 pm - 7:00 pm

Hall GH

Attendees and registered guests are invited to attend our Wine and Cheese Welcome Reception and Plenary Poster Session in the Exhibit Hall of the San Diego Convention Center. Simply display your badge for admission. Guests may purchase a badge for $50 at the ASBMR Registration Counter for entrance to the Welcome Reception. FR0002

Deletion of the Redox Amplifier p66shc Decreases ROS Production in Murine Bone and Increases Osteoblast Resistance to Oxidative Stress and Bone Mass Shoshana M. Bartell*, Li Han, Srividhya Iyer, Aaron Warren, Robert W. Bradsher, Randal S. Shelton, Maria Jose S. Almeida, Stavros C. Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Shoshana M. Bartell, None

FR0003

Insulin Signaling in Bone Favors Male Fertility Franck Oury*, Tatsuya Yoshizawa, Mathieu Ferron, Patricia Ducy, Gerard Karsenty. Columbia University, USA Disclosures: Franck Oury, None

FR0004

Nicotinamide Phosphoribosyltransferase (Nampt) Affects the Lineage Fate Determination of Mesenchymal Stem Cells: A Possible Cause for Reduced Osteogenesis and Increased Adipogenesis In Senile Osteoporosis Yan Li*1, Xu He2, Urban Lindgren1. 1Karolinska Institute, Sweden, 2a Karolinska Institute; b Jilin University, Sweden Disclosures: Yan Li, None

FR0005

2011 ASBMR YOUNG INVESTIGATOR AWARD The ß-catenin Activating Factor, Wnt3a, stimulates Skeletal Muscle Myogenesis Sandra Romero-Suarez*1, ChengLin Mo 2, Nuria Lara3, Katharina Jaehn3, Mark Johnson4, Lynda Bonewald3, Marco Brotto3. 1Muscle Biology Group-MUBIG, School of Nursing, University of Missouri-Kansas City, USA, 2Muscle Biology Group-MUBIG, School of Nursing & Pharmacy, University of Missouri-Kansas City, USA, 3University of Missouri - Kansas City, USA, 4University of Missouri, Kansas City Dental School, USA Disclosures: Sandra Romero-Suarez, None

13

Friday

POSTERS AND EXHIBITS OPEN

FR0009

Genetic Variation in DHCR7/NADSYN1 (rs12785878) Predicts Skeletal Muscle Response to Resistance Training and Vitamin D Levels in Men Sreya Talasila1, Jordan Ruby1, F Orkunoglu-Suer2, H Gordish-Dressman2, K Panchapakesan2, BT Harmon2, Eric Hoffman2, Joe Devaney2, Laura Tosi*2. 1George Washington University School of Medicine, USA, 2Children’s National Medical Center, USA Disclosures: Laura Tosi, None

FR0010

High Serum Adiponectin Is Associated with Frailty and Predicts Mortality in Elderly Men. Mr OS Sweden Dan Mellstrom*1, Helena Johansson2, Carl-Johan Behre3, Hans Jutberger2, John Kanis4, ˚ sa Tivesten3, Ulf Lerner2, Magnus Karlsson5, O ¨ sten Ljunggren6, Claes Anders Ode´n2, A Ohlsson7, Mattias Lorentzon8. 1Sahlgrenska University Hospital, Sweden, 2Centre for Bone & Arthritis Research (CBAR), Sahlgrenska Academy University of Gothenburg Sweden, Sweden, 3Wallenberg Laboratory for Cardiovascular Research. Institute of Medicine, University of Gothenburg, Sweden, 4University of Sheffield, Belgium, 5Clinical & Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University & Department of Orthopaedics, Malmo¨ University Hospital, Malmo¨, Sweden, Sweden, 6Department of Medical Sciences, University of Uppsala, Uppsala, Sweden, Sweden, 7Centre for Bone & Arthritis Research, Sweden, 8Center for Bone Research at the Sahlgrenska Academy, Sweden Disclosures: Dan Mellstrom, None

FR0011

Lean Mass and the Longitudinal Probability of Mobility Disability in the Framingham Study: A Multinomial Approach for Studies of Aging Robert McLean*1, Elizabeth Newton2, Alyssa Dufour2, Joanne Murabito3, Marian Hannan4, Douglas Kiel2. 1Hebrew SeniorLife, Harvard Medical School, USA, 2Hebrew SeniorLife, USA, 3Framingham Heart Study & Boston University, USA, 4HSL Institute for Aging Research & Harvard Medical School, USA Disclosures: Robert McLean, None

FR0013

Trunk Muscle Fat Infiltration is Greater in Women than Men and Increases with Age Dennis Anderson*1, John D’Agostino1, Alexander Bruno2, Douglas Kiel3, Mary Bouxsein 1. 1Beth Israel Deaconess Medical Center, USA, 2Stony Brook University, USA, 3 Hebrew SeniorLife, USA Disclosures: Dennis Anderson, None

FR0020

A Childhood Fracture is a Risk Factor for Both Low BMD at Growth and Low Peak Bone Mass - a Mean 28 Years Prospective Controlled Study Magnus Karlsson1, Christian Buttazzoni* 2, Lennart Landin 3, Jan-Ake Nilsson3, Bjorn Rosengren 1, Magnus Tveit4. 1Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 2 Department of Clinical Sciences & Orthopaedics, Lund University, Sweden, 3Departement of Clinical Sciences & Orthopaedics, Lund University, Sweden, 4Clinical & Molecular Osteoporosis Research Unit, Sweden Disclosures: Christian Buttazzoni, None

FR0023

Feeding Blueberry Diets during Early Development Is Sufficient to Prevent Senescence of Osteoblasts and Bone Loss in Adulthood Jin-Ran Chen*1, Jian Zhang2, Oxana P. Lazarenko2, Michael L. Blackburn2, Kartik Shankar 2, Thomas M. Badger2, Martin J. Ronis 2. 1University of Arkansas for Medical Science, Arkansas Children’s Nutrition Center, USA, 2UAMS/ACNC, USA Disclosures: Jin-Ran Chen, None

FR0025

Interactions of Maternal and Postnatal Diet Alter Skeletal Acquisition in Male and Female Mice: Evidence for Developmental Programming of Bone Acquisition Maureen Devlin*, Leeann Louis, Christine Conlon, Alison Cloutier, Mary Bouxsein. Beth Israel Deaconess Medical Center, USA Disclosures: Maureen Devlin, None

FR0026

Sport-Specific Association Between Exercise Loading and Density, Geometry, and Microstructure of Weight-Bearing Bone in Young Adult Men Martin Nilsson*1, Claes Ohlsson2, Dan Mellstrom3, Mattias Lorentzon4. 1Centre for Bone & Arthritis Research At the Sahlgrenska Academy, Sweden, 2Centre for Bone & Arthritis Research, Sweden, 3Sahlgrenska University Hospital, Sweden, 4Center for Bone Research at the Sahlgrenska Academy, Sweden Disclosures: Martin Nilsson, None

14

FR0029

Determinants of Improvements in Bone Mineral Density (BMD) and Structure Following Initiation of Infliximab (IFX) Therapy for Childhood Crohn Disease (CD) Meena Thayu*1, Justine Shults2, Robert Baldassano2, Babette Zemel3, Mary Leonard3. 1 The Children’s Hospital of Philadelphia, USA, 2University of Pennsylvania School of Medicine, USA, 3Children’s Hospital of Philadelphia, USA Disclosures: Meena Thayu, None

FR0030

High Incidence of New Vertebral Fractures in Children with Leukemia after 12 Months of Chemotherapy: Results of the Canadian Steroid-associated Osteoporosis in the Pediatric Population (STOPP) Research Program N. Alos*1, R. Grant2, J. Halton3, S. Atkinson4, D. Cabral5, R. Couch6, E. Cummings 7, M. Matzinger 3, P.M. Miettunen8, H. Nadel5, C. Rodd9, N. Shenouda3, D. Stephure 8, R. Stein10, S. Taback11, F. Rauch9, B. Lentle5, K. Siminoski6, L.M. Ward3, - and the Canadian STOPP Consortium12. 1Universite´ de Montre´al, Canada, 2University of Toronto, Canada, 3University of Ottawa, Canada, 4McMaster University, Canada, 5University of British Columbia, Canada, 6University of Alberta, Canada, 7Dalhousie University, Canada, 8 University of Calgary, Canada, 9McGill University, Canada, 10University of Western Ontario, Canada, 11University of Manitoba, Canada, 12Canadian Pediatric Bone Health Working Group, Canada Disclosures: N. Alos, None

Mechanism of Hexa-D-Arginine Curative Effects on the HYP Phenotype Baozhi Yuan*1, Stephen Bowman2, Robert Blank2, Iris Lindberg3, Marc Drezner2. 1 University of Wisconsin, Madison, USA, 2University of Wisconsin, USA, 3University of Maryland, USA Disclosures: Baozhi Yuan, None

FR0044

Increased Cortical Bone Mass Is Associated with Increased Bone Strength by Treatment with the Cathepsin K Inhibitor, ONO-5334, but not with Alendronate in Ovariectomized Monkeys Yasuo Ochi* 1, Hiroyuki Yamada2, Yasutomo Nakanishi 2, Akiko Kunishige2, Satoshi Nishikawa2, Yasuaki Hashimoto2, Hiroshi Mori2, Masafumi Sugitani2, Kazuhito Kawabata 2. 1Ono Pharmaceutical Co.,Ltd., Japan, 2Ono Pharmaceutical Co., Ltd., Japan Disclosures: Yasuo Ochi, None

FR0045

In-situ synchrotron SAXS Combined with Micromechanical Testing to Serve as an In-Vitro Nanomechanical Functional Imaging Technique to Measure the Bone Quality Degradation in Metabolic Bone Diseases Angelo Karunaratne* 1, Himadri Gupta1, Rrajesh Thakker2, Chris Esapa3, Jennifer Hiller4, Alan Boyde5, Nick J. Terrill4, Asa Barber6, J. H. D. Bassett7, Roger Cox8, S. Brown8, Matthew Brown9, R Head10, Peter Croucher11, Graham Williams7. 1School of Engineering & Material Sciences, Queen Mary University of London, United Kingdom, 2Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology & Metabolism, United Kingdom, 3Academic Endocrine Unit, Nuffield Department of Clinical Medicine, United Kingdom, 4I22 Non-crystalline Diffraction Diamond Light Source Harwell Science & Innovation Campus, United Kingdom, 5Queen Mary University of London, Oral Growth & Development, Institute of Dentistry, Bart’s & The London School of Medicine, United Kingdom, 6 School of Engineering & Material Sciences, Queen Mary University of London, United Kingdom, 7Molecular Endocrinology Group, MRC Clinical Sciences Centre & Division of Investigative Sciences, Imperial College London, United Kingdom, 8MRC Mammalian Genetics Unit & Mary Lyon Centre, MRC Harwell, Harwell Science & Innovation Campus, United Kingdom, 9 Diamantina Institute of Cancer, Immunology & Metabolic Medicine, Australia, 10 Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, United Kingdom, 11The Mellaby Centre for Bone Research, United Kingdom Disclosures: Angelo Karunaratne, None

FR0049

Non-Invasive Assessment of Bone Marrow Lipids Captures Fracture Risk Profile of Postmenopausal Women Irrespective of Diabetes History Janina Patsch*1, Thomas Baum2, Paran S. Yap2, Xiaojuan Li2, Dimitrios Karampinos 2, Sharmila Majumdar2, Ann Schwartz2, Thomas M. Link2. 1UCSF, USA, 2University of California, San Francisco, USA Disclosures: Janina Patsch, None

15

Friday

FR0032

FR0052

Pubertal Influences on Bone Strength: Results from the Fels Longitudinal Study Maja Seselj*1, Ramzi W. Nahhas1, Richard J. Sherwood 2, Wm. Cameron Chumlea1, Roger M. Siervogel 1, Stefan A. Czerwinski 1, Bradford Towne2, Dana L. Duren3. 1Lifespan Health Research Center, Department of Community Health, Wright State University, USA, 2 Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Pediatrics, Wright State University, USA, 3Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Orthopaedic Surgery, Wright State University, USA Disclosures: Maja Seselj, None

FR0058

The Effect of Denosumab on the Bone Matrix Mineralization in Mice Barbara Misof1, Paul Roschger*1, Michael Ominsky2, Phaedra Messmer 1, Paul Kostenuik 3, Klaus Klaushofer 1. 1Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria, 2Amgen, Incorporated, USA, 3Amgen, Inc., USA Disclosures: Paul Roschger, None

FR0059

The Loss of ATF4 Reduces the Toughness of Bone Jeffry Nyman*1, Alexander Makowski2, Sandra Wadeer2, Matthew Murry2, Xiangli Yang2. 1Vanderbilt University Medical Center, USA, 2Vanderbilt University, USA Disclosures: Jeffry Nyman, VA, 2

FR0061

Women with Type 2 Diabetes Have Increased Femoral Neck BMD but Not Increased Femoral Strength Dana Carpenter*1, Joyce Keyak2, Janina Patsch2, Paran Yap2, Thomas Baum2, Ann Schwartz 1, Thomas Lang2, Thomas Link2. 1University of California, San Francisco, USA, 2 University of California, USA Disclosures: Dana Carpenter, None

FR0062

Bone Tissue Micromechanical Properties are Altered Independently of Mineralization in Postmenopausal Osteoporotic Women Long-Term Treated with Alendronate Yohann Bala*1, Baptiste Depalle1, Thierry Douillard2, Sylvain Meille 2, Je´rome Chevalier2, Roland Chapurlat3, Georges Boivin1. 1INSERM, UMR 1033 ; Universite de Lyon, France, 2 INSA Lyon, MATEIS, CNRS 5510, France, 3E. Herriot Hospital, France Disclosures: Yohann Bala, None

FR0063

Development and Validation of a Mouse Model of Adynamic Bone Disease (ABD) Adeline Ng*1, Benjamin Alman2, Marc Grynpas3. 1University of Toronto Samuel Lunenfeld Research Institute, Canada, 2SICK CHILDREN’S HOSPITAL, Canada, 3 Samuel Lunenfeld Research Institute, Canada Disclosures: Adeline Ng, None

FR0066

Incidence of Skeletal Fractures After Spinal Cord Injury Laia Gifre*1, Pilar Peris2, Joan Vidal3, Jesu´s Benito3, Enric Portell3, Margarida Valle`s 3, Ana Monegal1, Nu´ria Guan˜abens1. 1Hospital Clı´nic of Barcelona, Spain, 2Hospital Clinic of Barcelona, Spain, 3Spinal Cord Unit. Guttmann Institute, Spain Disclosures: Laia Gifre, None

FR0067

QTL that Define Trabecular Bone’s Micro-mechanical Adaptations to Altered Mechanical Demand Engin Ozcivici*1, Weidong Zhang2, Leah Rae Donahue3, Stefan Judex4. 1Izmir Institute of Technology, Turkey, 2Jackson Laboratories, USA, 3Jackson Laboratory, USA, 4Stony Brook University, USA Disclosures: Engin Ozcivici, None

FR0068

The Role of Oxidative Stress and Antioxidant Enzymes In Bone Under Mechanical Unloading Daichi Morikawa*1, Yoshitomo Saita2, Hidetoshi Nojiri2, Keiji Kobayashi1, Kenji Watanabe 1, Yoshinori Asou3, Kazuo Kaneko2, Takahiko Shimizu1. 1Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan, 2Department of Orthopaedics, Juntendo Univ., Japan, 3Tokyo Medical & Dental University, Japan Disclosures: Daichi Morikawa, None

16

FR0069

A Physiome Map of Mechanical and Pharmaceutical Treatment in a Mouse Model of Postmenopausal Osteoporosis Gisela Kuhn*1, Claudia Weigt2, Floor Lambers2, Ralph Mu¨ller 3. 1ETH Zu¨rich, Switzerland, 2Institute for Biomechanics, ETH Zurich, Switzerland, 3ETH Zurich, Switzerland Disclosures: Gisela Kuhn, None

FR0070

Does Loading Direction Influence the Cell’s Response to High Frequency, Low Magnitude Vibration? Sarah Manske*, Gunes Uzer, Stefan Judex. Stony Brook University, USA Disclosures: Sarah Manske, None

FR0071

Inhibition of Angiogenesis during Loading Induced Osteogenesis using avb3-targeted Nanoparticle Delivery of Fumagillin Ryan Tomlinson* 1, Anne Schmieder1, Gregory Lanza1, Matthew Silva2. 1Washington University in St. Louis, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Ryan Tomlinson, None

FR0072

Disclosures: Buer Sen, None FR0073

Mechanical Loading Activates Integrin a5b1 Leading to the Opening of Connexin 43 Hemichannels in Osteocytes - a Mechanism for Extracellular Release of Small Bone Anabolic Factors Nidhi Batra1, Sirisha Burra 2, Sumin Gu2, Xuechun Xia 3, Lynda Bonewald4, Eugene Sprague2, Martin Schwartz5, Jean Jiang*6. 1University of Texas Health Science Center at San Antonio (UTHSCSA), USA, 2University of Texas Health Science Center, USA, 3 University of Florida, USA, 4University of Missouri - Kansas City, USA, 5University of Virginia, USA, 6University of Texas Health Science Center at San Antonio, USA Disclosures: Jean Jiang, None

FR0074

Runx2 S301,S319 phosphorylation Controls Mechanical Force-Induced Osteoblast Gene Expression In Vitro and In Vivo. Yan Li*1, Chunxi Ge2, Jason Long1, Jose Rodriguez2, Dana Begun 1, Steven Goldstein3, Renny Franceschi4. 1University of Michigan, USA, 2University of Michigan School of Dentistry, USA, 3University of Michigan Orthopedic Research Labs, USA, 4Dept of Periodontics & Oral Medicine, University of Michigan School of Dentistry, USA Disclosures: Yan Li, None

FR0078

Inhibition of the SDF-1/CXCR4 Signaling Axis Attenuates Load-Induced Bone Formation Sara Temiyasathit 1, Philipp Leucht2, Vasavi Ramachandran1, Christopher Jacobs3, Jill Helms2, Alesha Castillo*4. 1Veterans Affairs Palo Alto Medical Center, USA, 2Stanford University, USA, 3Columbia University, USA, 4Palo Alto Veterans Affairs Medical Center, USA Disclosures: Alesha Castillo, None

FR0079

Role of CKIP-1 in Normal Fracture Healing Yixin He*1, Baosheng Guo 2, Zhong Liu3, Dahu Li 4, Fuchu He4, Lingqiang Zhang4, Ling Qin5, Ge Zhang6. 1The Cuinese University of Hong Kong, Hong Kong, 2Prince of Wales Hospital, Hong Kong, 3The Chinese University of Hong Kong, Hong Kong, 4State Key Laboratory of Proteomics, Beijing Proteomics Research Center, The Academy of Military Medical Sciences, China, 5Chinese University of Hong Kong, Hong Kong, 6Prince of Wales Hospital, Hong Kong Disclosures: Yixin He, None

FR0086

Hdac3 Controls Growth Plate Matrix Secretion and Akt/mTOR Pathway Activation Elizabeth Bradley*, David Razidlo, Bridget Stensgard, Jennifer Westendorf. Mayo Clinic, USA Disclosures: Elizabeth Bradley, None

17

Friday

Mechanical Induction of Focal Adhesion Assembly in MSC Amplifies Anti-adipogenic Signaling Pathways Buer Sen*1, Christophe Guilluy2, Zhihui Xie 2, Natasha Case3, Maya Styner3, Jacob Thomas2, Ipek Oguz2, Clinton Rubin4, Keith Burridge2, Janet Rubin3. 1University of North Carolina At Chapel Hill, USA, 2UNC, USA, 3University of North Carolina, Chapel Hill, School of Medicine, USA, 4State University of New York at Stony Brook, USA

FR0087

Disruption of Mitogen Inducible Gene 6 (MIG6) in the Mouse Genome Accelerates Surgical Induced Osteoarthritis and Down Regulates Wnt Signaling Danese Joiner*1, Michael Morris2, Donald Scholten2, Ben Staal3, George Vande Woude3, Clifford Jones4, Debra Sietsema4, Yu-Wen Zhang3, Jim Mason5. 1Van Andel Research Institute, USA, 2Orthopaedic Cell & Tissue Mechanics Laboratory, Van Andel Research Institute, USA, 3Molecular Oncology Laboratory, Van Andel Research Institute, USA, 4 Orthopaedic Associates of Michigan, USA, 5Van Andel Institute, USA Disclosures: Danese Joiner, None

FR0088

NELL-1 Promotes Cartilage Regeneration in an In Vivo Rabbit Model Ronald Siu*1, Janette Zara2, Yaping Hou1, Jinny Kwak1, Xinli Zhang1, Aaron James1, Karina Covarrubias1, Benjamin Wu 1, Kang Ting1, Chia Soo1, Min Lee1. 1University of California, Los Angeles, USA, 2UCLA, USA Disclosures: Ronald Siu, None

FR0089

PTHrP Blocks Thyroid Hormone Signaling Through PP2A/HDAC4/Mef2 Pathway in Growth Plate Chondrocytes Lai Wang*, Yvonne Shao, R. Tracy Ballock. Cleveland Clinic, USA Disclosures: Lai Wang, None

FR0090

Roles of the Heterotypic CCN2/CTGF-CCN3/NOV and Homotypic CCN2-CCN2 Interactions in Matrix Synthesis in Chondrocytes Mitsuhiro Hoshijima*1, Takako Hattori2, Eriko Aoyama3, Takashi Nishida1, Takashi Yamashiro4, Masaharu Takigawa 5. 1Okayama University, Japan, 2Department of Biochemistry & Molecular Dentistry Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 3Biodental Research Center, Okayama University Dental School, Japan, 4Department of Orthodontics & Dentofacial Orthopedics Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 5Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sci., Japan Disclosures: Mitsuhiro Hoshijima, None

FR0092

TGFb and Substrate Stiffness Interact to Direct Chondrocyte Differentiation Jessica Orr*1, Tamara Alliston2. 1University of California - San Francisco, USA, 2 University of California, San Francisco, USA Disclosures: Jessica Orr, None

FR0094

Vinculin-mediated Signaling from Extracellular Matrix Interacts with the Signaling Triggered by Humoral Factors and Regulates Chondrocyte Differentiation in a Sox9-independent Manner. Takao Koshimizu* 1, Masanobu Kawai1, Kanako Tachikawa 1, Keiichi Ozono2, Toshimi Michigami1. 1Osaka Medical Center & Research Institute for Maternal & Child Health, Japan, 2Osaka University Graduate School of Medicine, Japan Disclosures: Takao Koshimizu, None

FR0095

Wnt5a Signaling Gradient Controls Directional Cartilage Growth by Establishing Planar Cell Polarity in Chondrocytes Bo Gao*1, Hai Song1, Kevin Bishop1, Gene Elliot1, Lisa Garrett1, Milton English1, Philipp Andre1, James Robinson 1, Raman Sood1, Yasuhiro Minami2, Aris Economides3, Yingzi Yang4. 1National Human Genome Research Institute, USA, 2Kobe University, Japan, 3 Regeneron Pharmaceuticals, Inc., USA, 4NIH, USA Disclosures: Bo Gao, None

FR0098

Histone Deacetylase-4 Plays a Role in Palatogenesis Through the Regulation of Neural Crest Cell Migration in Zebrafish Yukio Nakamura* 1, April Delaurier2, Shigeyuki Wakitani3, Hiroyuki Kato4, Charles Kimmel2. 1Shinshu University School of Medicine, Japan, 2Institute of Neuroscience, University of Oregon, USA, 3Department of Health & Sports Sciences, Mukogawa Women’s University, Japan, 4Department of Orthopaedic Surgery, Shinshu University School of Medicine, Japan Disclosures: Yukio Nakamura, None

18

FR0100

Long-Chain Saturated Fatty Acids Promote the Differentiation of Cells of the Marrow Stromal Line Kusa4b10 into Adipocytes Dorit Naot*1, Jessica Costa 2, David S Musson1, Jian-Ming Lin1, Jillian Cornish1, Andrew Grey1. 1University of Auckland, New Zealand, 2University of Auckland, Nzl Disclosures: Dorit Naot, None

FR0106

Klf4 Regulates Osteoblast Differentiation Ikumi Michikami*, Makoto Abe. Osaka University Graduate School of Dentistry, Japan Disclosures: Ikumi Michikami, None

FR0111

Characterization of Collagen-GFP Transgenic Mice and Evidence for Osteocyte Deposition of Perilacunar Collagen Patricia Veno 1, Suzan Kamel1, Yongbo Lu2, Yixia Xie3, Karl Kadler4, Yinhui Lu5, Charlotte Phillips6, Vladimir Dusevich3, Sarah Dallas*3. 1University of Missouri, Kansas City, USA, 2Baylor College of Dentistry/Texas A&M Health Science Center, USA, 3 University of Missouri - Kansas City, USA, 4Wellcome Trust Center for Cell Matrix Research/University of Manchester, United Kingdom, 5Wellcome Trust Center for CellMatrix Research/University of Manchester, United Kingdom, 6University of MissouriColumbia, USA Disclosures: Sarah Dallas, None

Sympathetic Control of Bone Mass Regulated By Osteopontin Masashi Nagao*1, Yoshitomo Saita2, Ryo Hanyu3, Tadayoshi Hayata4, Tetsuya Nakamoto 5, Yayoi Izu5, Takuya Notomi6, Shu Takeda7, Gerard Karsenty8, Susan Rittling9, Yoichi Ezura10, Jean-Pierre Vilardaga11, Masaki Noda5. 1Juntendo University Nerima Hospital, Japan, 2Department of Orthopaedics, Juntendo University School of Medicine, Japan, 3Medical Reseach Institute, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5Tokyo Medical & Dental University, Japan, 6GCOE, Tokyo Medical & Dental University, Japan, 7Keio University, Dept. of Nephrology, Endocrinology & Metabolism, Japan, 8Columbia University, USA, 9The Forsyth Institute, USA, 10Tokyo Medical & Dental University, Medical Research Insititute, Japan, 11 University of Pittsburgh, School of Medicine, USA Disclosures: Masashi Nagao, None

FR0115

Temporal Analysis of mechanical force-induced bone formation Using Quantitative Proteomics based on 8 plex- iTRAQ Wei-Bing Zhang*1, Wei-Jie Zhong2, Lin Wang2. 1Nanjing Medical University, Chn, 2 Nanjing Medical University, China Disclosures: Wei-Bing Zhang, None

FR0116

Osteoblastic Cells Rely on MT1-MMP as a Regulator of Skeletal Homeostasis Emily Purcell*, Joanne Shi, Susan Yamada, Pamela Robey, Kenn Holmbeck. National Institute of Dental & Craniofacial Research, USA Disclosures: Emily Purcell, None

FR0119

Control of Iron Status Alters Phosphate Metabolism in a Mouse Model of Autosomal Dominant Hypophosphatemic Rickets (ADHR). Emily Farrow*1, Lelia Summers1, Munro Peacock2, Kenneth White1. 1Indiana University School of Medicine, USA, 2Indiana University Medical Center, USA Disclosures: Emily Farrow, None

FR0120

2011 ASBMR YOUNG INVESTIGATOR AWARD Fgf23 Regulates Calcium and Sodium Reabsorption in Renal Distal Tubules through SGK1 Signaling Olena Andrukhova*1, Carmen Streicher2, Ute Zeitz2, Beate Lanske3, Reinhold Erben2. 1 Inst. of Physiology, Pathophysiology & Biophysics, Austria, 2University of Veterinary Medicine, Austria, 3Harvard School of Dental Medicine, USA Disclosures: Olena Andrukhova, None

19

Friday

FR0114

FR0121

MEPE-derived Phosphorylated ASARM Is Involved in FGF23/soluble Klotho-dependent Hypomineralization Yukiko Konishi*1, Yuji Yoshiko2, Tomoko Minamizaki 1, Hirotaka Yoshioka1, Masahiro Maeda3, Atsushi Shimizu4, Jane Aubin5, Norihiko Maeda1. 1Hiroshima University Graduate School of Biomedical Sciences, Japan, 2Hiroshima University, Japan, 3ImmunoBiological Laboratories Co., Ltd, Japan, 4Raffinee International Co. Ltd., Japan, 5 University of Toronto Faculty of Medicine, Canada Disclosures: Yukiko Konishi, None

FR0124

Mice Expressing a Phosphorylation-Deficient PTH Receptor Have Blunted Calcemic and Phosphaturic Responses to Acute PTH Challenge Akira Maeda*1, Makoto Okazaki1, Matthew Mahon1, Hiroko Segawa1, Abdul AbouSamra2, Harald Jueppner1, John Potts1, Thomas Gardella1. 1Massachusetts General Hospital, USA, 2Wayne State University, School of Medicine, USA Disclosures: Akira Maeda, Chugai, 2

FR0126

PTHrP Regulated BMP Signaling Plays A Role in the Specification of the Mammary Mesenchyme Minoti Hiremath*1, Pamela Dann2, John Wysolmerski3. 1Boise State University, USA, 2 Yale University, USA, 3Yale University School of Medicine, USA Disclosures: Minoti Hiremath, None

FR0128

Silencing of PTH Receptor 1 in T Cells Blunts the Bone Anabolic Activity of Intermittent PTH Treatment Brahmchetna Bedi 1, Jau-Yi Li*1, Jonathan Adams1, Ming-Kang Chang2, Tatsuya Kobayashi 3, M. Neale Weitzmann4, Michaela Kneissel2, Henry Kronenberg 3, Roberto Pacifici1. 1Emory University School of Medicine, USA, 2Novartis Institutes for Biomedical Research, Switzerland, 3Massachusetts General Hospital, USA, 4Emory University School of Medicine, Atlanta VA Medical Center, USA Disclosures: Jau-Yi Li, None

FR0129

2011 ASBMR YOUNG INVESTIGATOR AWARD The Adjuvant Effects of Intermittent PTH Therapy on Massive Allograft Healing are Associated with Decreased Vasculogenesis via Differential Angiopoietin Expression and Increased Allograft Remodeling. Robinder Dhillon*1, Chao Xie 2, Laura Calvi 3, Regis O’Keefe4, Edward Schwarz4. 1 University of Rochester, Rochester, NY, USA, USA, 2Center for Musculoskeletal Research, University of Rochester, USA, 3University of Rochester School of Medicine, USA, 4University of Rochester, USA Disclosures: Robinder Dhillon, None

FR0131

The Transcriptional Co-Activator CITED1 is Required for Normal Bone Volume and for the Full Anabolic Response to PTH In Vivo Hila Bahar*1, Jun Guo2, Hiroaki Saito3, Rajaram Manoharan 4, Dehong Yang2, Toshi Shioda2, Mary Bouxsein4, Roland Baron5, F. Richard Bringhurst2. 1MGH & HMS, USA, 2 Massachusetts General Hospital, USA, 3Harvard School of Dental Medicine, USA, 4Beth Israel Deaconess Medical Center, USA, 5Harvard School of Medicine & of Dental Medicine, USA Disclosures: Hila Bahar, None

FR0132

Chronic Stress Increases Breast Cancer Metastasis to Bone via ß2AR on Osteoblasts Florent Elefteriou1, J. Campbell*2, Julie Sterling3, Xiangli Yang1. 1Vanderbilt University, USA, 2Vanderbilt Center for Bone Biology, USA, 3Vanderbilt University Medical Center, USA Disclosures: J. Campbell, None

FR0133

Genome-Wide Reciprocal Modulation of Runx2 and Estrogen Signaling in Breast Cancer Cells: Identification of a Clinically Prognostic Cell Cycle-Related Gene Cluster Nyam-Osor Chimge* 1, Sanjeev Baniwal1, Jingqin Luo2, Simon Coetzee1, Ben Berman1, Debu Tripathy1, Ellis Matthew2, Baruch Frenkel1. 1University of Southern California, USA, 2Washington University in St. Louis, USA Disclosures: Nyam-Osor Chimge, None

20

FR0135

Identification of Runx2 Responsive Genes Counter-regulated by Estrogen: SNAI2 as a Mediator of Runx2-induced Invasiveness Nyam-Osor Chimge*, Sanjeev Baniwal, Yunfan Shi, Baruch Frenkel. University of Southern California, USA Disclosures: Nyam-Osor Chimge, None

FR0136

Interleukin 6 Modulates Tumor Behavior in Bone via a RANKL Dependent Pathway Yu Zheng*1, Katja Boernert1, Anastasia Mikuscheva2, Dennis Basel 3, Robert L Sutherland 4, Frank Buttgereit2, Colin Dunstan5, Dr. Hong Zhou6, Markus Seibel6. 1Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 2 Department of Rheumatology & Clinical Immunology, Charite´ University Medicine (CCM), Germany, 3ANZAC Research Institute, the University of Sydney, Australia, 4 Cancer Research Program, Garvan Institute of Medical Research, Australia, 5University of Sydney, Australia, 6Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Yu Zheng, None

FR0137

Friday

PMEPA1, a Negative Regulator of Transforming Growth Factor-b (TGFb) Signaling Pathway, Inhibits Bone Metastases from Prostate Cancer in Mice Pierrick Fournier*1, Gregory Clines2, John Chirgwin1, Theresa Guise1. 1Indiana University, USA, 2University of Alabama at Birmingham, USA Disclosures: Pierrick Fournier, None

FR0138

The Development of Bone Metastatic Lesions Is Modified By Circulating Fibronectin Anja von Au, Matthaeus Vasel, Inaam Nakchbandi*. Max-Planck Institute for Biochemistry & University of Heidelberg, Germany Disclosures: Inaam Nakchbandi, None

FR0139

The Impact of Macrophage Depletion on Bone Homeostasis and Prostate Tumor Growth Fabiana Soki*1, Sun Wook Cho1, Amy Koh2, Serk In Park2, Laurie McCauley 3. 1 University of Michigan School of dentistry, USA, 2University of Michigan, USA, 3 University of Michigan, School of Dentistry, USA Disclosures: Fabiana Soki, None

FR0147

Host-derived Prostaglandin E Regulates Bone Metastases of Malignant Melanoma through Angiogenesis Morichika Takita1, Satoshi Yokoyama1, Masaki Inada*2, Chisato Miyaura1. 1Tokyo University of Agriculture & Technology, Japan, 2Toyko University of Agriculture & Technology, Japan Disclosures: Masaki Inada, None

FR0148

IAP antagonist BV6 Increases Bone Metastasis via NIK-Mediated Osteoclast Activation Chang Yang*1, Jennifer Davis2, Kathleen McCoy1, Roberta Faccio1, Deborah Novack3. 1 Washington University in St Louis School of Medicine, USA, 2Washington University in St. Louis, USA, 3Washington University in St. Louis School of Medicine, USA Disclosures: Chang Yang, None

FR0152

Oncologic Doses of Zoledronic Acid Induce ONJ-Like Lesions in Rice Rats (Oryzomys palustris) with Periodontitis J. Aguirre*1, Mohammed Akhter2, Jennfer Pingel3, Xuechun Xia3, Aly Williams3, Marda Jorgensen4, Kent Edmonds5, Mercy Rivera6, Lakshmyya Kesavalu6, Thomas Wronski1. 1 University of Florida, USA, 2Creighton University Osteoporosis Research Center, USA, 3 Department of Physiological Sciences, University of Florida, USA, 4Cell & Tissue Analysis Core, McKnight Brain Institute, University of Florida, USA, 5Department of Biology, Indiana University Southeast, USA, 6Department of Periodontology & Oral Biology, College of Dentistry, Univesity of Florida, USA Disclosures: J. Aguirre, None

FR0157

A Novel Mouse Model of Tibial Pseudarthrosis Featuring Localized Double Inactivation of the Nf1 Gene Aaron Schindeler* 1, Jad El-Hoss2, Kate Sullivan1, Tegan Cheng1, Kathy Mikulec1, Lauren Peacock1, Paul Baldock3, Ian Alexander4, David Little 1. 1The Children’s Hospital at Westmead, Australia, 2University of Sydney, Australia, 3Garvan Institute of Medical Research, Australia, 4Children’s Medical Research Institute, Australia Disclosures: Aaron Schindeler, Celgene Inc, 2

21

FR0158

Patients with Turner Syndrome and Isolated SHOX Deficiency Have Similar Bone Geometry At the Radius Ondrej Soucek*1, Jan Lebl 2, Jirina Zapletalova 3, Dana Novotna4, Ivana Plasilova5, Stanislava Kolouskova2, Dana Zemkova2, Miloslav Rocek6, Katerina Hirschfeldova7, Zdenek Sumnik2. 12nd Faculty of Medicine, Charles University, Prague, Czech Republic, 2 Department of Pediatrics, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Czech Republic, 3Department of Pediatrics, Palacky University, Faculty of Medicine, University Hospital Olomouc, Czech Republic, 4Department of Pediatrics, Masaryk University, Faculty of Medicine, University Hospital Brno, Czech Republic, 5 Department of Pediatrics, Charles University, Faculty of Medicine, University Hospital Hradec Kralove, Czech Republic, 6Department of Radiology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Czech Republic, 7Institute of Biology & Department of Medical Genetics, Charles University, 1st Faculty of Medicine, General University Hospital, Czech Republic Disclosures: Ondrej Soucek, None

FR0160

Unique Contributions of Endothelial vs. Smooth Muscle Msx Gene Expression In Arteriosclerotic LDLR-Deficient Mice Jian Su Shao1, Su-Li Cheng2, Abraham Behrmann 1, Kathryn Distelhorst1, Linda Halstead1, Robert Maxson3, Dwight Towler*1. 1Washington University in St. Louis, USA, 2 Washington University in St. Louis School of Medicine, USA, 3University of Southern California, USA Disclosures: Dwight Towler, None

FR0163

2011 ASBMR YOUNG INVESTIGATOR AWARD Measles Virus Nucleocapsid Protein induces Autophagy in Osteoclasts: Implications for the Pathogenesis of Paget’s Disease of Bone Feng-Ming Wang*, Deborah L. Galson. University of Pittsburgh, Medicine/HematologyOncology, The Center for Bone Biology of UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Feng-Ming Wang, None

FR0164

Microarray Profile of p62P392L and Measles Virus Nucleocapsid Protein (MVNP) Regulated Gene Expression During Osteoclast Differentiation Kumaran Sundaram*1, Srinivasan Shanmugarajan1, Sudhaker Rao2, Sakamuri Reddy1. 1 Charles P. Darby Children’s Research Institute, USA, 2Henry Ford Hospital, USA Disclosures: Kumaran Sundaram, None

FR0165

TANK Binding Kinase 1 (TBK1) Mediates MVNP Effects in Pagetic Osteoclasts Quanhong Sun*1, Benedicte Sammut1, Fengming Wang1, Jolene J. Windle2, Noriyoshi Kurihara1, G. David Roodman1, Deborah L. Galson1. 1University of Pittsburgh, Medicine/ Hematology-Oncology, The Center for Bone Biology of UPMC, & VA Pittsburgh Healthcare System, USA, 2Virginia Commonwealth University, Department of Human & Molecular Genetics, USA Disclosures: Quanhong Sun, None

FR0166

2011 ASBMR YOUNG INVESTIGATOR AWARD The Expression of Measles Virus Nucleocapsid Protein (MVNP) Gene in Osteoclasts (OCLs) Induces Expression of Coupling Factors that Stimulate Bone Formation Yoko Uehata*1, Jumpei Teramachi1, Jolene Windle2, Noriyoshi Kurihara1, G. David Roodman 3. 1University of Pittsburgh & The Center for Bone Biology at UPMC, USA, 2 Virginia Commonwealth University, USA, 3University of Pittsburgh, The Center for Bone Biology at UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Yoko Uehata, None

FR0177

High Turnover Renal Osteodystrophy is Associated with b-Catenin Repression in Osteocytes Yves Sabbagh*, Wen Tang, Christina Bracken, Stephen O’Brien, Lucy Phillips, Sue Ryan, Shiguang Liu, Susan Schiavi. Genzyme Corporation, USA Disclosures: Yves Sabbagh, Genzyme Corporation, 3

22

FR0178

2011 ASBMR YOUNG INVESTIGATOR AWARD Adenovirus-Mediated Gene Transfer of Adiponectin Reduces Osteoclasts Differentiation and Bone Erosion of Collagen-Induced Arthritis in Mice Kosuke Ebina*1, Kazuya Oshima1, Makoto Hirao2, Jun Hashimoto 1, Kenrin Shi1, Hideki Yoshikawa1. 1Osaka University, Graduate School of Medicine, Department of Orthopedics, Japan, 2Osaka University Graduate School of Medicine, Department of Orthopaedics, Japan Disclosures: Kosuke Ebina, None

FR0182

Bone Histomorphometry Findings in Pediatric Solid Organ Transplant Patients Inari Tamminen* 1, Helena Valta2, Hanna Isaksson3, Sari Salminen4, Mervi K. Mayranpaa 5, Hannu Jalanko5, Heikki Kroger6, Outi Makitie7. 1Bone & Cartilage research Unit (BCRU), University of Eastern Finland, Finland, 2Hospital for Children & Adolescents, University of Helsinki, Helsinki Finland, Finland, 3University of Eastern Finland, Finland, 4Children’s Hospital, Helsinki University Central Hospital, Finland, 5 Children’s Hospital, Helsinki University Central Hospital & University of Helsinki, Finland, 6Kuopio University Hospital, Finland, 7Hospital for Children & Adolescents, Helsinki University Hospital, Finland Disclosures: Inari Tamminen, None

PHOSPHO1: a Novel Therapeutic Target for Medial Vascular Calcification Tina Kiffer-Moreira*1, Manisha C. Yadav1, Dongxing Zhu2, Yalda Bravo3, Russell Dahl3, Sonoko Narisawa1, Boguslaw Stec1, Vicky E. MacRae2, Colin Farquharson 4, Jose´ Luis Milla´n 1. 1Sanford Children’s Health Research Center, Sanford-Burnham Medical Research Institute, USA, 2The Roslin Institute, The University of Edinburgh, United Kingdom, 3 Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, USA, 4The Roslin Institute, The University of Edinburgh, USA Disclosures: Tina Kiffer-Moreira, None

FR0187

A 4-bp Deletion Mutation in DLX3 Enhances Anti-adipogenic Activity of DLX3 Hye-Lim Lee*1, Kyung Hwa Baek2, Kyung Mi Woo3, Hyun-Mo Ryoo3, Gwan-Shik Kim1, Jeong-Hwa Baek1. 1Seoul National University School of Dentistry, South Korea, 2Seoul National Univeristy School of Dentistry, South Korea, 3Seoul National University, School of Dentistry, South Korea Disclosures: Hye-Lim Lee, None

FR0189

Differential Effect of ApoE Isoforms on Trabecular Bone Mass and Bone Turnover in Mice Marco Dieckmann1, F. Timo Beil2, R. Percy Marshall2, Alexander Bartelt2, Wolfgang Ruether2, Michael Amling 2, Joachim Herz3, Andreas Niemeier* 2. 1UT Southwestern Medical Center, USA, 2University Medical Center Hamburg-Eppendorf, Germany, 3Center for Alzheimer’s & Neurodegenerative Disease, USA Disclosures: Andreas Niemeier, None

FR0190

Etanercept for the Treatment of Inflammation in Cherubism Mice Teruhito Yoshitaka*1, Tomoyuki Mukai2, Ernst Reichenberger 3, Yasuyoshi Ueki 4. 1 University Missouri-Kansas City School of Dentistry, USA, 2University of Missouri Kansas City, USA, 3University of Connecticut Health Center, USA, 4University of Missouri-Kansas City School of Dentistry, USA Disclosures: Teruhito Yoshitaka, None

FR0191

Mechanisms of Bone Loss in Cystic Fibrosis Bone Disease Katrina Clines, Joon Chung, Gregory Clines*. University of Alabama at Birmingham, USA Disclosures: Gregory Clines, None

FR0192

Osteoanabolic Treatment of Adult Osteogenesis Imperfecta with Teriparatide: Preliminary Results of an 36-month prospective observational study Parvis Farahmand*1, Johann Ringe 1, Thomas Nickelsen 2. 1West German Osteoporosis Center, Leverkusen Clinic, University of Cologne, Germany, 2Eli Lilly Deutschland GmbH, Germany Disclosures: Parvis Farahmand, None

23

Friday

FR0186

FR0193

Over Expression of Tissue-nonspecific Alkaline Phosphatase in Osteoblasts Increases Bone Mineralization by Dephosphorylating Osteopontin Sonoko Narisawa* 1, Manisha Yadav2, Jose Luis Millan3. 1Sanford Burnham Medical Research Institute, USA, 2Burnham Institute for Medical Research, USA, 3SanfordBurnham Medical Research Institute, USA Disclosures: Sonoko Narisawa, None

FR0194

2011 ASBMR YOUNG INVESTIGATOR AWARD SH3BP2 Cherubism Mutation Enhances Lipopolysaccharide-induced Osteoclastogenesis Tomoyuki Mukai*1, Teruhito Yoshitaka2, Yasuyoshi Ueki 3. 1University of Missouri Kansas City, USA, 2University Missouri-Kansas City School of Dentistry, USA, 3 University of Missouri-Kansas City School of Dentistry, USA Disclosures: Tomoyuki Mukai, None

FR0195

Teriparatide Increases Bone Mineral Density in a Man with Osteoporosis Pseudoglioma John Bilezikian1, Marise Lazaretti Castro2, Elizabete Ribeiro Barros3, Henrique Arantes*4, Ilda Kunii3. 1Columbia University College of Physicians & Surgeons, USA, 2Federal University of Sao Paulo, Brazil, 3Sa˜o Paulo Federal University, Brazil, 4Brazil Disclosures: Henrique Arantes, None

FR0197

Bone Mineral Density is Reduced in Subjects with Familial Defective Apolipoprotein B-100 Laura Yerges-Armstrong*1, Haiqing Shen1, Elizabeth Streeten 2, Alan Shuldiner1, Braxton Mitchell3. 1University of Maryland, USA, 2University of Maryland School of Medicine, USA, 3University of Maryland, Baltimore, USA Disclosures: Laura Yerges-Armstrong, None

FR0199

Large-scale Meta-analysis of Genome-Wide Association Studies for Bone Mineral Density at Radius: the GEFOS Consortium Hou-Feng Zheng*1, Laura Yerges-Armstrong2, Joel Eriksson 3, Emma Duncan4, Braxton Mitchell5, Claes Ohlsson6, Elizabeth Streeten7, Mattias Lorentzon 8, Brent Richards9. 1 Department of Human genetics & Epidemiology & Biostatistics, McGill University, Canada, 2University of Maryland, USA, 3Center for Bone & Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Sweden, 4Royal Brisbane & Women’s Hospital, Australia, 5University of Maryland, Baltimore, USA, 6Centre for Bone & Arthritis Research, Sweden, 7University of Maryland School of Medicine, USA, 8Center for Bone Research at the Sahlgrenska Academy, Sweden, 9McGill University, Canada Disclosures: Hou-Feng Zheng, None

FR0201

Inflammation Induces Expression of BMP3, an Inhibitor of Bone Formation, in Inflammatory Arthritis Melissa Matzelle*1, Anita Shaw1, Jun Li1, Sougata Karmakar 1, Catherine Manning1, Nicole Walsh2, Vicki Rosen3, Ellen Gravallese1. 1University of Massachusetts Medical School, USA, 2St Vincent’s Institute of Medical Research, Australia, 3Harvard School of Dental Medicine, USA Disclosures: Melissa Matzelle, Abbott Bioresearch Center, 99

FR0202

Transplanted Mesenchymal Stem Cell-derived BMP2 Rescues Fracture Healing in BMP2deficient Mouse Limbs Timothy Myers*1, Froilan Granero-Molto2, Lara Longobardi 2, Yun Yan1, Tieshi Li 1, Ying Li1, Anna Spagnoli2. 1University of North Carolina, USA, 2University of North Carolina at Chapel Hill, USA Disclosures: Timothy Myers, None

FR0205

Analysis of Wnt System Components in Cranial Defect Healing in CXC Receptor Knock-out (mCXCR-/-) Mice by Microarray David Bischoff*1, Weibiao Huang1, Erwin Kruger2, Nalini Makhijani3, Dean Yamaguchi4. 1 VA Greater Los Angeles Healthcare System & David Geffen School of Medicine at UCLA, USA, 2UCLA, USA, 3VA GLAHS, USA, 4VA Greater Los Angeles Healthcare System, USA Disclosures: David Bischoff, None

FR0206

Differential Impact of Dkk1 Neutralizing Antibodies on Wnt Signaling and Bone Mineral Density Wei Fan*1, Grisanti Mario1, Jilin Sun1, Hsieng S. Lu 1, Xiaodong Li 2, William G. Richards 1. 1Amgen Inc., USA, 2Amgen Inc, USA Disclosures: Wei Fan, Amgen, Inc, 1; Amgen, Inc, 3

24

FR0208

Increased WNT Signaling in Sclerostin/Sostdc1 Double Knockouts Causes Preaxial Polydactyly Richard Harland1, Deepa Murugesh2, Gabriela Loots3, Cristal Yee4, Nicole Collette*2. 1 University of California, Berkeley, USA, 2Lawrence Livermore National Laboratory, USA, 3LLNL/UC Merced, USA, 4University of California, Merced, USA Disclosures: Nicole Collette, None

FR0209

Intermittent Injections of Osteocalcin Improve Glucose Metabolism and Prevent Type 2 Diabetes In Mice Mathieu Ferron*1, Marc McKee2, Patricia Ducy1, Gerard Karsenty1. 1Columbia University, USA, 2McGill University, Canada Disclosures: Mathieu Ferron, None

FR0210

Modulation of SDF-1/CXCR4 Axis Enhances rhBMP-2-induced Ectopic Bone Formation Joel Wise, D. Rick Sumner, Amarjit Virdi*. Rush University Medical Center, USA Disclosures: Amarjit Virdi, None

FR0211

New Function of Nell-1 Protein in Regulating Bone Maintenance Aaron James*1, Xinli Zhang1, Janette Zara2, Michael Chiang1, Wei Yuan 1, Raghav Goyal1, Cymbeline Culiat3, Kang Ting1, Chia Soo1. 1University of California, Los Angeles, USA, 2UCLA, USA, 3Oak Ridge Laboratories, USA

FR0213

Transgenic Adult Murine Mesenchymal Stem Cells Conditionally Overexpressing SDF-1b Enhance New Bone Formation in Both In Vitro and In Vivo Model Systems Samuel Herberg*, Sadanand Fulzele, Nianlan Yang, Galina Kondrikova, Khaled Hussein, Mohammed E. Elsalanty, Maribeth Johnson, Xingming Shi, Mark Hamrick, William D. Hill. Georgia Health Sciences University, USA Disclosures: Samuel Herberg, None

FR0214

Ephrin B2-EphB4 Bidirectional Signaling Mediates the Actions of IGF-I Signaling in Regulating Chondrocyte and Osteoclast Differentiation Yongmei Wang*, Hashem Elalieh, Wenhan Chang, Daniel Bikle. Endocrine Unit, University of California, San Francisco/VA Medical Center, USA Disclosures: Yongmei Wang, None

FR0215

Requirement of Shp2 in Chondrogenesis and Cartilage Homeostasis Yingnan Yu*1, Jianguo Wang2, Kai Zhao2, Douglas Moore2, Zhengke Wang3, Qian Wu4, Di Chen5, Quesenberry Peter6, Wentian Yang7. 1Brown University Alpert Medical School & Rhode Island Hospital, Providence, RI, USA, 2Departments of Orthopedics, RI Hospital & Brown University Alpert Medical School, USA, 3Roger Williams Hospital, USA, 4 Department of Pathology & Laboratory Medicine, University of Connecticut Health Center, USA, 5Center for Musculoskeletal Research, Department of Orthopaedics & Rehabilitation, University of Rochester, Rochedter, NY, USA, 6Departments of Medicine, RI Hospital & Brown University Alpert Medical School, USA, 7Brown University Alpert Medical School, USA Disclosures: Yingnan Yu, None

FR0223

Decreased Bone Formation and Bone Resorption Following Fracture in Osteoblast-Osteocyte Specific Connexin 43 Deficient Mice Alayna Loiselle*1, Emmanuel Paul2, Gregory Lewis2, Henry Donahue3. 1Penn State Hershey, USA, 2Penn State College of Medicine, USA, 3The Pennsylvania State University College of Medicine, USA Disclosures: Alayna Loiselle, None

FR0224

Disruption of the Runx2 Response to SMAD signaling Affects Bone Turn-over in Adult Mice Yang Lou*1, Sadiq Hussain2, Dana Frederick2, Andre Van Wijnen 2, Gary Stein 2, Jane Lian2, Janet Stein2. 1University of Massachusetts, USA, 2University of Massachusetts Medical School, USA Disclosures: Yang Lou, None

25

Friday

Disclosures: Aaron James, None

FR0231

Osterix Deficiency Disrupts Ameloblast and Odontoblast Maturation but Not Tooth Morphogenesis Ji-Myung Bae*1, Harunur Rashid1, Haiyan Chen2, David Summerford1, Mitra Adhami1, Dobrawa Napierala3, Krishna Sinha4, Soraya Gutierrez5, Benoit DeCrombrugghe4, Amjad Javed2. 1School of Dentistry, University of Alabama at Birmingham, USA, 2University of Alabama at Birmingham, USA, 3University of Alabama at Birmingham, School of Dentistry, USA, 4UT MD Anderson Cancer Center, USA, 5Universidad De Concepcion, Chile Disclosures: Ji-Myung Bae, None

FR0232

Protection of Bone Loss by Targeting of Semaphorin 4D Expressed by Osteoclasts Takako Koga*1, Masahiro Shinohara2, Hiroshi Takayanagi 1. 1Tokyo Medical & Dental University, Japan, 2Tokyo Medical & Dental University, Jpn Disclosures: Takako Koga, None

FR0233

R-spondin 2 is a New Key Player in Human Osteoarthritis Osteoblasts to Orchestrate Their Abnormal Canonical Wnt Signaling Elie Abed*1, Thomas Chan1, Aline Delalandre 1, Johanne Martel-Pelletier 1, Jean-Pierre Pelletier1, Daniel Lajeunesse2. 1CHUM, Hoˆpital Notre-Dame, Canada, 2CRCHUM, Hoˆpital Notre-Dame, Canada Disclosures: Elie Abed, None

FR0235

Vitamin D Signaling in Osteoblasts/Osteocytes Is Required to Shift Calcium from Bone to Serum Liesbet Lieben*1, Karen Moermans1, Lynda Bonewald2, Jian Feng3, Geert Carmeliet1. 1 Katholieke Universiteit Leuven, Belgium, 2University of Missouri - Kansas City, USA, 3 Texas A&M Health Science Center, USA Disclosures: Liesbet Lieben, None

FR0241

Environment Contaminant Tributyltin-Induced Osteoporosis: Distinct Involvement of PPARc and RXR in Suppression of Osteogenesis Amelia Baker*1, Brett D Meeks 1, Faye V. Andrews2, Danielle Salazar 1, Louis Gerstenfeld1, Jennifer Schlezinger 3. 1Boston University School of Medicine, USA, 2Boston University School of Public Health, USA, 3Boston University School of Public Health, USA Disclosures: Amelia Baker, None

FR0242

Epigenetic Regulation of Mesenchymal Cell Commitment to the Osteoblast Lineage by Dlx3 Jonathan Gordon*1, Mohammad Hassan1, Hai Wu1, Maria Morasso2, Andre Van Wijnen1, Janet Stein1, Gary Stein1, Jane Lian1. 1University of Massachusetts Medical School, USA, 2Developmental Skin Biology Section, NIAMS/NIH, USA Disclosures: Jonathan Gordon, None

FR0243

Expression of Dlx3 in Neural Crest-derived Cells Is Essential for Normal Formation of Craniofacial Bones Olivier Duverger1, Juliane Isaac*1, Anne K. Bartels1, Angela Zah1, Jane Lian 2, Ariane Berdal3, Joonsung Hwang1, Maria I. Morasso1. 1Developmental Skin Biology Section, NIAMS/NIH, USA, 2University of Massachusetts Medical School, USA, 3INSERM, UMRS 872, Universites Paris 5 & 6, Team 5, France Disclosures: Juliane Isaac, None

FR0245

Identification of a Transcriptional Network Associated with Osteoblast Activity Using Systems Genetics Charles Farber*1, Ana Lira1, Brian Bennett2, Luz Orozco2, Hyun Kang2, Calvin Pan2, Eleazar Eskin2, Aldons Lusis2. 1University of Virginia, USA, 2University of California, Los Angeles, USA Disclosures: Charles Farber, None

FR0250

Overexpression of Transcription Factor Pitx1 Inhibits Osteoblast Differentiation and Bone Mineralization Alain Moreau*1, Nancy Karam2, Anita Franco3. 1Sainte-Justine Hospital, Canada, 2 Sainte-Justine University Hospital Research Center, Canada, 3Sainte-Justine-University Hospital Research Center, Canada Disclosures: Alain Moreau, None

26

FR0252

Activation of Distinct Nucleotide Receptor Subtypes Determines the Duration of CalciumNFATc1 Signaling in Osteoblasts over a Remarkably Wide Dynamic Range of ATP Concentrations: A Novel Mechanism for Dose-to-Duration Coupling Matthew Grol*1, Shu Xing2, Alexey Pereverzev1, Stephen M. Sims1, Svetlana Komarova2, S. Jeffrey Dixon1. 1The University of Western Ontario, Canada, 2McGill University, Canada Disclosures: Matthew Grol, None

FR0253

PTH differentially regulates PRG expression in Osteoblasts Hyewon Choi*1, Clara Magyar1, Guillermo Arellano2, Olga Bezouglaia1, Jeanne Nervina3, Sotirios Tetradis4. 1University of California, Los Angeles, USA, 2University of Nevada, Las Vegas, USA, 3University of Michigan, USA, 4UCLA, USA Disclosures: Hyewon Choi, None

FR0254

The p38a MAPK Regulates Osteoblast Function and Postnatal Bone Acquisition Cyril Thouverey1, Joseph Caverzasio*2. 1Division of Bone Diseases, Switzerland, 2Division Bone Diseases, Switzerland Disclosures: Joseph Caverzasio, None

FR0255

Disclosures: Martina Rauner, None FR0259

Connexin43 (Cx43) in Osteogenic Cells Regulates Osteoclastogenesis via Paracrine Osteoprotegerin (OPG) Production, without Direct Osteoblast-Osteoclast Gap Junctional Communication Marcus Watkins*, Roberto Civitelli. Washington University in St. Louis School of Medicine, USA Disclosures: Marcus Watkins, None

FR0260

CXCR4 Signaling in Osteoblasts is Essential for Bone Homeostasis Vivian Chu1, Mohammad Shahnazari*2, Thomas Wronski3, Bernard Halloran1. 1VA Medical Center (111N), USA, 2UCSF VA Medical Center, USA, 3University of Florida, USA Disclosures: Mohammad Shahnazari, None

FR0262

Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells Nick Van Gastel*1, Scott Roberts2, Sophie Torrekens1, Jan Schrooten 1, Frank Luyten3, Geert Carmeliet1. 1Katholieke Universiteit Leuven, Belgium, 2KULeuven, Belgium, 3 University Hospitals KU Leuven, Belgium Disclosures: Nick Van Gastel, None

FR0267

PPR-Dependent Signaling in the Osteoblast Lineage Regulates Bone Marrow B Cell Development Cristina Panaroni*1, Rhiannon Chubb1, Joy Wu2. 1Endocrine Unit, Massachusetts General Hospital, USA, 2Massachusetts General Hospital, USA Disclosures: Cristina Panaroni, None

FR0268

The Host Immune Response to Allogeneic and Syngeneic Mesenchymal Stem Cells Modulates Osteogenesis Scott Yang*, Vedavathi Madhu, Abhijit Dighe, Gary Balian, Quanjun Cui. University of Virginia, USA Disclosures: Scott Yang, None

27

Friday

WNT5A Is a Novel Regulator of Cytokine and Chemokine Expression In Bone Marrow Stromal Cells Martina Rauner*1, Nicola Stein2, Maria Winzer2, Claudia Goettsch3, Lorenz Hofbauer4. 1 Medical Faculty of the TU Dresden, Germany, 2Technical University Dresden, Department of Medicine III, Germany, 3Department of Medicine III, Technical University, Dresden, USA, 4Dresden Technical University Medical Center, Germany

FR0269

2011 ASBMR YOUNG INVESTIGATOR AWARD Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevent Bone Loss in Ovariectomized Nude Mice Jee Hyun An*1, Jung Ah Song1, Kyoung Ho Ki 1, Sol Ip Jung1, Jae-Yeon Yang1, Hyung Jin Choi1, Sun Wook Cho2, Sang Wan Kim3, Seong Yeon Kim1, Soo Jin Choi4, Wonil Oh4, Chan Soo Shin 1. 1Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 2University of Michigan School of Dentistry, USA, 3Seoul National University Boramae Hospital, South Korea, 4Biomedical Research Institute, MEDIPOST, Co., Ltd., South Korea Disclosures: Jee Hyun An, None

FR0274

The Association Between the Microtubule Plus End Protein EB1 And Cortactin Controls Podosomes And Bone Resorption Martin Biosse Duplan*1, Sebastien Stephens1, Frank PL Lai2, Margit Oelkers3, Daisuke Kitamura4, Klemens Rottner3, William Horne1, Roland Baron5. 1Harvard School of Dental Medicine, USA, 2Institute of Medical Biology, Immunos, Singapore, 3Institute of Genetics, University of Bonn, Germany, 4Research Institute for Biological Sciences, Tokyo University of Science, Japan, 5Harvard School of Medicine & of Dental Medicine, USA Disclosures: Martin Biosse Duplan, None

FR0279

Unique RANKL Determinants Associated with RANK Versus OPG Engagement Julia Warren*, Christopher Nelson, Yik Yu, Steven Teitelbaum, Daved Fremont. Washington University in St. Louis School of Medicine, USA Disclosures: Julia Warren, None

FR0281

Apoptotic Osteocytes Promote In Vitro Osteoclastogenesis Directly through RANKL and Indirectly Through M-CSF and VEGF Saja Al-Dujaili* 1, Esther Lau 1, Axel Guenther1, Lidan You2. 1University of Toronto, Canada, 2Mechanical & Industrial Engineering, University of Toronto, Canada Disclosures: Saja Al-Dujaili, None

FR0283

Diacylglycerol Maintains Bone Homeostasis by Regulating Osteoclast Differentiation and Function Corinne Decker*1, Viviana Cremasco2, Roberta Faccio3. 1Washington University in St. Louis, USA, 2Washington University School of Medicine, USA, 3Washington University in St Louis School of Medicine, USA Disclosures: Corinne Decker, None

FR0284

Dual Osteoclast Precursor and Suppressor Function of a Ly6Chi Population Increased in Murine Inflammatory Arthritis Julia Charles*1, Lih-Yun Hsu2, Erene C. Niemi2, Arthur Weiss2, Mary Nakamura 2. 1 University of California, San Francisco & VA Medical Center, USA, 2University of California, San Francisco, USA Disclosures: Julia Charles, None

FR0285

Dynamic in vivo Imaging of Bone-Resorptive Functions of Mature Osteoclasts in Live Bones By Using Intravital Two-Photon Microscopy Junichi Kikuta*1, Yoh Wada2, Masaru Ishii 1. 1Immunology Frontier Research Center, Osaka University, Japan, 2Institute of Scientific & Industrial Research, Osaka University, Japan Disclosures: Junichi Kikuta, None

FR0287

Identification and Characterization of OCAN, a Novel Osteoclastogenic Co-activator for NFATc1 Min-Young Youn*1, Sally Fujiyama-Nakamura1, Yuuki Imai1, Shigeaki Kato2. 1The University of Tokyo, Japan, 2University of Tokyo, Japan Disclosures: Min-Young Youn, None

FR0289

Microtubule Contribution to Osteoclastogenesis – Stathmin Deficiency Induces Low Bone Mass In Mice by Increasing Osteoclastogenesis Hongbin Liu* 1, Rongrong Zhang1, Babatunde Oyajobi2, Hong-Wen Deng1, Ming Zhao1. 1 Tulane University, USA, 2University of Texas Health Science Center at San Antonio, USA Disclosures: Hongbin Liu, None

28

FR0290

Molecular Basis of the Requirement of RANK Signaling for Interleukin-1 (IL-1)-Mediated Osteoclastogenesis Joel Jules*, Jason Ashley, Ping Zhang, Shi Wei, Zhenqi Shi, Jianzhong Liu, Suzanne Michalek, Xu Feng. University of Alabama at Birmingham, USA Disclosures: Joel Jules, None

FR0291

NIBP: A Novel Regulator of Osteoclast Differentiation and Function Kevin Crawford*1, Joyce Belcher2, Roshanak Razmpour1, Yonggang Zhang3, Wen-Hui Hu3, Steven Popoff1, Fayez Safadi1. 1Temple University School of Medicine, USA, 2 Temple University, School of Medicine, USA, 3Temple University School of Medicine Department of Neuroscience, USA Disclosures: Kevin Crawford, None

FR0292

Osteoclasts in Bone Modeling, As Revealed By In Vivo Imaging, Are Essential for Organogenesis in Fish Masahiro Chatani*1, Yoshiro Takano2, Akira Kudo1. 1Tokyo institute of technology, Japan, 2Tokyo Medical & Dental University, Japan Disclosures: Masahiro Chatani, None

FR0293

Disclosures: Yi-Ping Li, None FR0299

IL-17 Mediates Estrogen-deficient Osteoporosis Carl DeSelm*1, Yoshifumi Takahata2, Jean Chappel2, Taimur Khan2, Xiaoxia Li 3, Wei Zou4, Steven Teitelbaum4. 1Washington University School of Medicine, USA, 2Washington University in St. Louis, USA, 3Cleveland Clinic, USA, 4Washington University in St. Louis School of Medicine, USA Disclosures: Carl DeSelm, None

FR0303

The ADP receptor P2Y12 Regulates Osteoclast Function and Pathologic Bone Loss Xinming Su*1, Desiree Floyd2, alun hughes3, Kaiming Wu2, Ozge Uluckan2, Sarah Townsley2, Angela Hirbe2, Jochen Schneider4, Emanuella Heller2, Michelle Hurchla2, Hongju Deng2, Mark Eagleton2, Deborah Novack5, Pamela Conley2, Michael Rogers3, Katherine Weilbaecher5. 1Washington University in Saint Louis, USA, 2Washington University in St. Louis, USA, 3University of Aberdeen, United Kingdom, 4Washu, USA, 5 Washington University in St. Louis School of Medicine, USA Disclosures: Xinming Su, None

FR0305

P21Ras Mediated Activation of PI3K Results in Enhanced Survival of Osteoclasts in the Absence of Cbl-PI3K Interaction Independent of Cbl-b Nagasuresh Adapala*1, Alexander Tsygankov2, Mary Barbe1, Archana Sanjay1. 1Temple University School of Medicine, USA, 2Temple University, USA Disclosures: Nagasuresh Adapala, None

FR0306

Selective Deletion of Rac1 and Rac2 in Mature Osteoclasts Results in Osteopetrosis, Failed Tooth Eruption and Defects in both Osteoclast and Osteoblast Function Meiling Zhu*1, Ben-hua Sun1, Katarzyna Kolodziejczak1, Karl Insogna2. 1Yale University, USA, 2Yale University School of Medicine, USA Disclosures: Meiling Zhu, None

FR0307

The Rho-GEF Kalirin Regulates Dynamin’s GTPase Activity and Osteoclast Function Pierre Eleniste*, Su Huang, Heather Largura, Angela Bruzzaniti. Indiana University School of Dentistry, USA Disclosures: Pierre Eleniste, None

FR0309

Constitutive Protein Kinase A Activities in Osteocytes Leads to Increased Bone Formation without Increased Bone Resorption Richard Kao*1, Wei-Dar Lu2, Dylan O’Carroll2, Peter Mailhot2, Robert Nissenson 3. 1 UCSF/VAMC, USA, 2VA Medical Center, USA, 3VA Medical Center & University of California, San Francisco, USA Disclosures: Richard Kao, None

29

Friday

Runt-related transcription factor 1 (Runx1) Regulates Macrophage/Osteoclast Lineage Commitment and Osteoclast Differentiation Wei Chen, Yi-Ping Li*. University of Alabama at Birmingham, USA

FR0310

2011 ASBMR YOUNG INVESTIGATOR AWARD Estrogen Receptor a (ERa) Expression in Osteocytes is Necessary to Maintain Normal Bone Mineral Density (BMD) and Reduce Bone Loss due to Unloading Yuuki Imai1, Lynda Bonewald2, Shino Kondoh*1, Shigeaki Kato3. 1The University of Tokyo, Japan, 2University of Missouri - Kansas City, USA, 3University of Tokyo, Japan Disclosures: Shino Kondoh, None

FR0311

NFATc1 Expression in Osteocytes Regulates Bone Formation by Regulating Sclerostin Expression Todd Spears*1, Jennifer Paige-Robinson2, Majd Zayzafoon1. 1University of Alabama at Birmingham, USA, 2University of Alabama-Birmingham, USA Disclosures: Todd Spears, None

FR0312

Pharmacological Activation of Canonical Wnt Signaling Improves Bone Homeostasis and Regeneration by Directly Promoting MSC Osteoblast Differentiation Tripti Gaur*1, John Wixted1, Sadiq Hussain1, Jennifer Colby1, Mary Clare McCorry1, Stacey Russell1, Ellen Gravallese1, Andre Van Wijnen1, Ivo Kalajzic2, David Rowe2, Janet Stein1, Gary Stein1, Jane Lian 1. 1University of Massachusetts Medical School, USA, 2 University of Connecticut Health Center, USA Disclosures: Tripti Gaur, None

FR0317

Association of the a2d1 Subunit with Cav3.2 Enhances Membrane Expression and Regulates Mechanically-Induced ATP Release and ERK1/2 Signaling in Osteocytes William Thompson*1, Amber Majid2, Kirk Czymmek2, Albert Ruff3, Jesu´s Garcı´a4, Randall Duncan1, Mary Farach-Carson5. 1University of Delaware, USA, 2University of Delaware, Department of Biological Sciences, USA, 3US Army Medical Research Institute of Chemical Defense, Cell & Molecular Biology Branch, Research Division, USA, 4University of Illinois at Chicago, Department of Physiology & Biophysics, USA, 5Rice University, USA Disclosures: William Thompson, None

FR0319

2011 ASBMR YOUNG INVESTIGATOR AWARD Evidence that Osteocytes Elaborate Endocrine Regulation of Internal Organs Size: Data From the Osteocytes IGF-I Conditional Knockout Mice Xiaodong Zhou*1, Kin-Hing William Lau2, Lynda Bonewald3, David Baylink1, Matilda Sheng1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3University of Missouri - Kansas City, USA Disclosures: Xiaodong Zhou, None

FR0325

Allowing Patient Self-Referral of DXA Significantly Improves Osteoporosis Screening Amy Warriner*1, Ryan Outman2, Jeffrey Curtis 2, Adrianne Feldstein3, David Redden2, Mary Rix 3, Brandi Robinson3, Douglas Roblin3, Ana Rosales3, Monika Safford2, Kenneth Saag2. 1UAB, USA, 2University of Alabama at Birmingham, USA, 3Kaiser Permanente Center for Health Research, USA Disclosures: Amy Warriner, None

FR0327

Degenerative Changes at the Lumbar Spine - Implications for Bone Mineral Density Measurement in Elderly Women Kristina Akesson*1, Max Tenne 2, Jack Besjakov3, Paul Gerdhem 4, Fiona McGuigan5. 1 Ska˚ne University Hospital, Malmo¨, Sweden, 2Clinical & Molecular Osteoporosis Research Unit, Department of Clinical Science Malmo, Lund University, Sweden, 3Dept of Radiology Malmo¨, Ska˚ne University Hospital, Malmo¨, Sweden, 4Karolinska Institutet, Sweden, 5University of Lund, Malmo¨, Skane University Hospital, Malmo¨, Sweden Disclosures: Kristina Akesson, None

FR0328

Distal Forearm BMD combined with FRAX Probabilities for Fracture Prediction Sreekanth Vasireddy1, Helena Johansson 2, Anders Oden3, Diane Charlesworth1, John Kanis4, Eugene McCloskey*1. 1University of Sheffield, United Kingdom, 2Swedish University of Agricultural Sciences, The Biomedical Center, Sweden, 3University of Gothenberg, Sweden, 4University of Sheffield, Belgium Disclosures: Eugene McCloskey, None

FR0330

Forearm BMD Measurement Variability Using DXA Diane Krueger*1, Nellie Vallarta-Ast2, Jessie Libber3, Mary Checovich1, Neil Binkley3. 1 University of Wisconsin, Madison, USA, 2UW Osteoporosis Research, USA, 3University of Wisconsin, USA Disclosures: Diane Krueger, None

30

FR0331

Rate of BMD Change Does Not Enhance Fracture Prediction: The Manitoba BMD Cohort William Leslie*1, Suzanne Morin2, Lisa Lix3. 1University of Manitoba, Canada, 2McGill University Health Centre, Canada, 3University of Saskatchewan, Canada Disclosures: William Leslie, None

FR0332

The Discriminatory Capacity of Clinical Risk Factors and BMD Measurements at Different Skeletal Sites for Detecting Patients with Vertebral Fractures Christian Muschitz* 1, Friederike Kuehne2, Roland Kocijan3, Angela Trubrich2, Christina Bittighofer 2, Reinhart Waneck4, Heinrich Resch5. 1St. Vincent’s Hospital, Austria, 2The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 3 St.Vincent Hospital Vienna, Austria, 4St. Vincent Hospital - Department of Radiology, Austria, 5Medical University Vienna, Austria Disclosures: Christian Muschitz, None

FR0335

Disclosures: Colin Miller, BioClinica, 3; Novartis Pharmaceuticals, 6 FR0339

Quantitative Ultrasound Measurements Predict Fracture Risk in Non-osteoporotic Women Tuan Nguyen1, John Eisman1, Jacqueline Center1, Mei Chan*2, Nguyen Nguyen1. 1Garvan Institute of Medical Research, Australia, 2Osteoporosis & Bone Biology, Australia Disclosures: Mei Chan, M & D, Roche and Novartis, 99

FR0347

Peri-Aortic Fat Is Negatively Associated with Volumetric Bone Mineral Density, CrossSectional Area and Compressive Strength of Lumbar Vertebrae: the Framingham Osteoporosis Study Yi-Hsiang Hsu*1, Caroline S. Fox2, Mary Bouxsein3, Udo Hoffmann4, LA Cupples5, Douglas Kiel6. 1Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 2National Heart, Lung, & Blood’s Framingham Heart Study, USA, 3Beth Israel Deaconess Medical Center, USA, 4Massachusetts General Hospital, Department of Cardiac MR PET CT & Harvard University, USA, 5Biostatstics Dept., School of Public Health, Boston University, USA, 6Hebrew SeniorLife, USA Disclosures: Yi-Hsiang Hsu, None

FR0353

Determination of Absolute Risk of Fracture Threshold for Intervention: A Decision Curve Analysis Nguyen Nguyen*1, Dana Bliuc 1, Steven Frost2, Jacqueline Center1, John Eisman1, Tuan Nguyen1. 1Garvan Institute of Medical Research, Australia, 2University of Western Sydney, Australia Disclosures: Nguyen Nguyen, None

FR0354

Epidemiologic Findings Shed Light Upon A Case Definition For Atypical Subtrochanteric and Femoral Shaft Femoral Fractures (STFSF) Adrianne Feldstein* 1, Dennis Black2, Nancy Perrin3, A. Gabriela Rosales 3, Darin Friess4, David Boardman5, Richard Dell6, Arthur Santora7, Julie Chandler7, Anne De Papp8, Mary Rix9, Eric Orwoll4. 1Kaiser Permanente Center for Health Research, USA, 2University of California, San Francisco, USA, 3Kaiser Permanente Northwest, Center for Health Research, USA, 4Oregon Health & Science University, USA, 5Kaiser Permanente NW, USA, 6Kaiser, USA, 7Merck Research Laboratories, USA, 8Merck & Co., Inc., USA, 9 Kaiser Permanente NW, Center for Health Research, USA Disclosures: Adrianne Feldstein, Amgen, 2; Merck, 2

FR0355

Incidence of and Predictors of False Negative Self-Reports of Hip Fractures in Cohort Studies: the Study of Osteoporotic Fractures (SOF) Beth Virnig1, Brent Taylor1, Kristine Ensrud2, Misti Paudel1, Sara Durham1, John Schousboe* 3. 1University of Minnesota, USA, 2Minneapolis VA Medical Center / University of Minnesota, USA, 3Park Nicollet Clinic, University of Minnesota, USA Disclosures: John Schousboe, None

31

Friday

Reproducibility of a Vertebral Deformity Tool (VDT) using an Statistical Shape Modeling Workflow Tool Colin Miller*1, Alan Brett2, Eric Bogner3, Monique Tan4, Rebecca Cope 5, Melanie Jenkins6, Jane Haslam7, Joes Staal8, Curtis Hayes 9. 1BioClinica, Inc. (formerly Bio-Imaging Technologies, Inc.), USA, 2Optasia Medical Ltd., United Kingdom, 3Hospital for Special Surgery, USA, 4Novartis Pharmaceutical, USA, 5BioClinica Inc, USA, 6Novartis Pharmaceuticals, USA, 7Optasia Medical Ltd, United Kingdom, 8Optasia Medical, United Kingdom, 9Virginia Commonwealth University School of Medicine, USA

FR0357

Muscle Density, a Surrogate of Intermuscular Adiposity Derived from pQCT, Is an Independent Correlate of Fractures in Women Andy Kin On Wong*1, Aakash Bhargava1, Karen Beattie1, Christopher Gordon1, Laura Pickard1, Colin Webber2, Alexandra Papaioannou 2, Jonathan Adachi3. 1McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3St. Joseph’s Hospital, Canada Disclosures: Andy Kin On Wong, None

FR0358

Novel Genetic Factors and Biological Pathways Influencing BMD and Risk of Fracture Karol Estrada*1, Evangelis Evangelou 2, Yi-Hsiang Hsu3, Unnur Styrkarsdottir 4, Ching-Ti Liu5, Alireza Moayyeri 6, Stephen Kaptoge7, Emma Duncan8, Dave Evans9, Najaf Amin 10, Ling Oei 11, Ulrika Pettersson12, Terence O’Neill13, Jose Riancho14, Osten Ljunggren15, Francois Rousseau16, William Leslie 17, David Goltzman18, Barbara Obermayer 19, Bente Langdahl20, Xavier Nogue´s21, Richard Prince22, Paul Lips 23, Sulin Cheng24, Janja Marc25, George Dedoussis26, Panagoula Kollia 26, Maria Luisa Brandi27, Lynne Hocking28, Rita Khusainova29, Cyrus Cooper30, Rebecca Jackson31, Terho Lehtimaki 32, Jung-Min Koh 33, Claus Christiansen34, John Eisman35, Nelson Tang36, Daniel Chasman37, Vilmundur Gudnason38, Stella Trompet39, Paul M Ridker37, Douglas Kiel40, David Karasik40, Omar Albagha41, Matthew Brown42, Tim Spector43, M Zillikens44, Claes Ohlsson45, Gudmar Thorleifsson4, Jonathan Reeve46, Liesbeth Vandenput47, Ryan Minster48, Candace Kammerer 49, Laura Yerges-Armstrong50, Brent Richards51, Jane Cauley49, Annie Kung52, Daniel Koller53, John Ioannidis2, Stuart Ralston41, Andre Uitterlinden 54, Fernando Rivadeneira 1, for the AOGC, GENOMOS and GEFOS consortia55. 1Erasmus University Medical Center, The Netherlands, 2University of Ioannina School of Medicine, Greece, 3 Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 4 Decode Genetics, Iceland, 5Boston University School of Public Health, USA, 6University of Cambridge, United Kingdom, 7University of Cambridge Bone Research Group, United Kingdom, 8Royal Brisbane & Women’s Hospital, Australia, 9University of Bristol, United Kingdom, 10Erasmus University Medical Center, Netherlands, 11Erasmus University Medical Center, The Netherlands, 12Umea University, Sweden, 13Manchester University, United Kingdom, 14University of Cantabria, Spain, 15Uppsala University Hospital, Sweden, 16Universite´ Laval & CHUQ, Canada, 17University of Manitoba, Canada, 18 McGill University Health Centre, Canada, 19Medical University, Austria, 20Aarhus Sygehus, Aarhus University Hospital, Denmark, 21Autonomous University of Barcelona, Spain, 22Sir Charles Gairdner Hospital, Australia, 23VU University Medical Center, The Netherlands, 24University of Jyva¨skyla¨, Finland, 25University of Ljubljana, Slovenia, 26 University of Athens, Greece, 27University of Florence, Italy, 28University of Aberdeen, United Kingdom, 29Institute of Biochemistry & Genetics USC RAS, Russia, 30University of Southampton, United Kingdom, 31The Ohio State University, USA, 32Tampere University Hospital, Finland, 33Asan Medical Center, South Korea, 34CCBR, Center for Clinical & Basic Research, Denmark, 35Garvan Institute of Medical Research, Australia, 36The Chinese University of Hong Kong, China, 37Brigham & Women’s Hospital, USA, 38 Icelandic Heart Association Research Institute, Iceland, 39Leiden University Medical Center, Netherlands, 40Hebrew SeniorLife, USA, 41University of Edinburgh, United Kingdom, 42Diamantina Institute of Cancer, Immunology & Metabolic Medicine, Australia, 43King’s College London, United Kingdom, 44Erasmus MC Rotterdam, The Netherlands, 45Centre for Bone & Arthritis Research, Sweden, 46Addenbrookes Hospital, United Kingdom, 47University of Gothenburg, Sweden, 48University of Pittsburgh, USA, 49 University of Pittsburgh Graduate School of Public Health, USA, 50University of Maryland, USA, 51McGill University, Canada, 52Dr. Kung-Wai Chee Clinic, Hong Kong, 53 Indiana University School of Medicine, USA, 54Rm Ee 575, Genetic Laboratory, The Netherlands, 55USA Disclosures: Karol Estrada, None

FR0359

Objective Assessment of Physical Activity and Risk of Non-spine Fractures: Osteoporotic Fractures in Men Study: (MrOS) Jane Cauley*1, Stephanie Harrison2, Dawn Mackey 3, Kristine Ensrud4, Eric Orwoll5, Peggy Cawthon6. 1University of Pittsburgh Graduate School of Public Health, USA, 2San Francisco Coordinating Center, USA, 3CPMC Research Institute, USA, 4Minneapolis VA Medical Center / University of Minnesota, USA, 5Oregon Health & Science University, USA, 6California Pacific Medical Center Research Institute, USA Disclosures: Jane Cauley, None

32

FR0366

Interaction of Genome Wide Variants with Dietary Vitamin D Intake on Serum Vitamin D Concentration: The Framingham Osteoporosis Study Yue Fang*1, Ching-Ti Liu2, Yi-Hsiang Hsu3, Adrienne Cupples4, David Karasik5, Douglas Kiel5. 1Hebrew Seniorlife Center at Harvard Medical School, USA, 2Boston University School of Public Health, USA, 3Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 4Department of Biostatistics, Boston University School of Public Health, USA, 5Hebrew SeniorLife, USA Disclosures: Yue Fang, None

FR0367

Disclosures: Daniel Koller, None FR0368

Women With Inadequately Controlled Type 2 Diabetes Are At Increased Risk of Osteoporotic Fractures Despite Higher Bone Mineral Density: The Rotterdam Study Ling Oei*1, Martha Castano-Betancourt2, Huibert Pols 3, Abbas Dehghan4, Andre Uitterlinden 5, Fernando Rivadeneira3, M Zillikens6. 1Erasmus University Medical Center, The Netherlands, 2Erasmus MC, The Netherlands, 3Erasmus University Medical Center, The Netherlands, 4Erasmus MC, Netherlands, 5Rm Ee 575, Genetic Laboratory, The Netherlands, 6Erasmus MC Rotterdam, The Netherlands Disclosures: Ling Oei, None

FR0369

BMD and Breast Cancer Risk: A Positive Association in Women >50 Years and a Negative in Women ,50 Years? The HUNT Study, Norway Siri Forsmo* 1, Kathinka Slørdahl 2, Arnulf Langhammer3. 1Norwegian University of Science & Technology, Norway, 2Faculty of Medicine, Norwegian University of Science & Technology, Norway, 3Dept. of Public Health & General Practice, Norwegian University of Acience & Technology, Norway Disclosures: Siri Forsmo, None

FR0375

Fat Mass and Fracture Risk in Elderly Men and Women: A Prospective Study Shuman Yang* 1, Nguyen Nguyen2, Jacqueline Center2, John Eisman2, Tuan Nguyen2. 1 Garvan Institute, Australia, 2Garvan Institute of Medical Research, Australia Disclosures: Shuman Yang, None

FR0377

Fracture Incidence in Obese Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women Juliet Compston*1, Nelson Watts2, Roland Chapurlat3, Cyrus Cooper4, Steven Boonen5, Susan Greenspan6, Johannes Pfeilschifter7, Stuart Silverman8, Adolfo Diez-Perez9, Robert Lindsay10, Kenneth Saag 11, Coen Netelenbos 12, Stephen Gelhbach13, Frederick Hooven14, Julie Flahive13, Jonathan Adachi15, Maurizio Rossini16, Andrea Lacroix17, Christian Roux18, Philip Sambrook19, Ethel Siris 20. 1University of Cambridge School of Clinical Medicine, United Kingdom, 2University of Cincinnati Bone Health & Osteoporosis Center, USA, 3E. Herriot Hospital, France, 4University of Southampton, United Kingdom, 5Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 6University of Pittsburgh, USA, 7Alfried Krupp Krankenhaus Steele, Germany, 8Cedars-Sinai/UCLA, USA, 9Autonomous University of Barcelona, Spain, 10Helen Hayes Hospital, USA, 11 University of Alabama at Birmingham, USA, 12VU Medical Center, The Netherlands, 13 UMass Medical School, USA, 14University of Massachusetts Medical School, USA, 15 St. Joseph’s Hospital, Canada, 16University of Verona, Italy, 17Fred Hutchinson Cancer Research Center, USA, 18Hospital Cochin, France, 19Royal North Shore Hospital, Australia, 20Columbia University College of Physicians & Surgeons, USA Disclosures: Juliet Compston, None

33

Friday

Meta-analysis of Genome-wide Association Studies in Premenopausal White Women Identifies Variants in WNT16, ESR1, and Novel BMD Loci Daniel Koller*1, David Karasik2, Hou-Feng Zheng3, Laura Yerges-Armstrong4, Ching-Ti Liu5, Dongbing Lai1, Karol Estrada6, Fernando Rivadeneira6, Andre Uitterlinden 7, Sylvie Giroux8, Francois Rousseau9, Stefan Czerwinski10, Bradford Towne10, Michael Econs1, Braxton Mitchell11, Brent Richards3, Douglas Kiel2, Tatiana Foroud1. 1Indiana University School of Medicine, USA, 2Hebrew SeniorLife, USA, 3McGill University, Canada, 4 University of Maryland, USA, 5Boston University School of Public Health, USA, 6 Erasmus University Medical Center, The Netherlands, 7Rm Ee 575, Genetic Laboratory, The Netherlands, 8Centre de recherche CHUQ-SFA, Canada, 9University Laval, Canada, 10 Wright State University Boonshoft School of Medicine, USA, 11University of Maryland, Baltimore, USA

FR0380

New Loop Diuretic Prescriptions Increase the Acute Risk of Hip Fracture Sarah Berry*1, Yanyan Zhu2, Hyon Choi2, Douglas Kiel3, Yuqing Zhang2. 1Hebrew SeniorLife/Beth Israel Deaconess Medical Center, USA, 2Boston University School of Medicine, USA, 3Hebrew SeniorLife, USA Disclosures: Sarah Berry, None

FR0383

QCT vBMD and Vascular and Valvular Calcification: The Framingham Study Elizabeth Samelson*1, Christopher O’Donnell2, Kerry Broe3, Udo Hoffmann4, Sekar Kathiresan2, Serkalem Demissie5, L. Adrienne Cupples5, Mary Bouxsein 6, Douglas Kiel7. 1 Hebrew SeniorLife, Harvard Medical School, USA, 2National Heart, Lung & Blood Institute’s Framingham Heart Study, USA, 3Hebrew Senior Life, USA, 4Massachusetts General Hospital, USA, 5Department of Biostatistics, Boston University School of Public Health, USA, 6Beth Israel Deaconess Medical Center, USA, 7Hebrew SeniorLife, USA Disclosures: Elizabeth Samelson, None

FR0384

Temporal Trends in 25-Hydroxyvitamin D levels and parathyroid hormone in a populationbased study Claudie Berger*1, Linda Greene-Finestone2, Lisa Langsetmo3, Lawrence Joseph1, Nancy Kreiger4, Brent Richards1, Christopher Kovacs5, Kurtis Sarafin6, K. Shawn Davison7, Jonathan Adachi8, Jacques Brown7, David Hanley9, David Goltzman10. 1McGill University, Canada, 2Public Health Agency of Canada, Canada, 3Canandian Multicenter Osteoporosis Study, Canada, 4University of Toronto, Canada, 5Memorial University of Newfoundland, Canada, 6Health Canada, Canada, 7Laval University, Canada, 8St. Joseph’s Hospital, Canada, 9University of Calgary, Canada, 10McGill University Health Centre, Canada Disclosures: Claudie Berger, None

FR0385

The Association Between Fracture and Obesity Is Site-Depending: A Population-Based Study Daniel Prieto-alhambra*1, Francesc Fina Aviles2, Eduard Hermosilla3, Daniel MartinezLaguna4, Cristina Carbonell5, Robert Gu¨erri 6, Xavier Nogues6, Adolfo Diez-Perez6. 1 Institut Municipal D’Investigacio´ Me`dica, Spain, 2SIDIAP Database, IDIAP Jordi Gol i Gurina; Barcelona Primary Care Dept, Institut Catala de la Salut, Spain, 3SIDIAP Database, IDIAP Jordi Gol i Gurina, Spain, 4Barcelona Primary Health Care Department, Institut Catala` de la Salut, Spain, 5Healthy Primary Care Via Roma Barcelona.Facultat de Medicina Universitat de Barcelona, Spain, 6Department of Internal Medicine, URFOA IMIM-Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona,RETICEF(Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain, Spain Disclosures: Daniel Prieto-alhambra, None

FR0391

Blockade of Endogenous Gi Signaling in Osteoblasts Stimulates Bone Formation and Prevents Age-Related Bone Loss Liping Wang*1, Susan M. Millard2, Dylan O’Carroll1, Lalita Wattanachanya3, Richard Kao4, Wei-Dar Lu 1, Aaron J. Fields 5, Jeffrey C. Lotz5, Robert Nissenson3. 1VA Medical Center, San Francisco, USA, 2University of Queensland, Australia, 3VA Medical Center & University of California, San Francisco, USA, 4UCSF/VAMC, USA, 5Department of Orthopaedic Surgery, UCSF, USA Disclosures: Liping Wang, None

FR0392

Chronic Central Administration of Ghrelin Increases Bone Mass Through Mechanisms Independent of Appetite Regulation Hyung Jin Choi*1, Kyoung Ho Ki 1, Jae-Yeon Yang1, Bo Young Jang1, Jung Ah Song1, Wook-Young Baek2, Jung Hee Kim3, Jee Hyun An1, Sang Wan Kim4, Seong Yeon Kim1, Jung-Eun Kim5, Chan Soo Shin1. 1Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 2Department of Molecular Medicine, Cell & Matrix Research Institute, Kyungpook National University School of Medicine, South Korea, 3Seoul National University College of Medicine, South Korea, 4Seoul National University Boramae Hospital, South Korea, 5Kyungpook National University School of Medicine, South Korea Disclosures: Hyung Jin Choi, None

34

FR0394

Circulating Sclerostin Levels and Bone Turnover in Type 1 and 2 Diabetes Ranuccio Nuti*1, Roberto Valenti2, Daniela Merlotti1, Elena Ceccarelli3, Martina Ruvio3, Maria Giulia Pietrini3, Cosimo Capodarca 3, Maria Beatrice Franci3, Anna Calabro`3, Konstantinos Stolakis3, Francesco Dotta3, Luigi Gennari1. 1University of Siena, Italy, 2S. Maria Alle Scotte Hospital, Italy, 3Dept. Internal Medicine Endocrine Metabolic Sciences & Biochemistry University of Siena, Italy Disclosures: Ranuccio Nuti, None

FR0396

Bone Microarchitecture Assessment in Postmenopausal Women with Atypical Fractures of the Femur and Long Term Bisphosphonate Therapy Maria Belen Zanchetta* 1, Aan Galich2, mirena buttazzoni3, maria diehl 3, Candela Fernandez 4, fernando silveira3, Fabio Massari1, Cesar Bogado1, Jose Ruben Zanchetta1. 1 Instituto de Investigaciones Metabolicas (IDIM), Argentina, 2Instituto De Investigaciones Metabolicas, Argentina, 3md, Argentina, 4Hospital De Clinicas - Universidad De Buenos Aires, Argentina Disclosures: Maria Belen Zanchetta, None

FR0402

Disclosures: Delphine Maurel, None FR0405

Anti-Retroviral Therapy Drives Bone Loss in AIDS Patients as a Consequence of Immune Reconstitution Ighovwerha Ofotokun1, Tatyana Vikulina1, Ashwini Vunnava1, Susanne Roser-Page1, Masayoshi Yamaguchi1, Francois Villinger1, Kenneth Rogers1, Majd Zayzafoon 2, Anandi Sheth1, Jeffrey Lennox1, M. Neale Weitzmann*1. 1Emory University School of Medicine, USA, 2University of Alabama at Birmingham, USA Disclosures: M. Neale Weitzmann, None

FR0407

Circulating Levels of Sclerostin Are Increased In Patients With Type 2 Diabetes Mellitus Antonia Garcı´a-Martı´n*1, Pedro Rozas-Moreno 2, Sonia Morales-Santana3, Beatriz Garcı´a-Fontana3, Jose´ Antonio Garcı´a-Salcedo4, Rebeca Reyes5, Manuel Munoz-Torres6. 1 Bone Metabolic Unit. Endocrinology Division., Spain, 2Endocrinology Division. Hospital General de Ciudad Real. Ciudad Real, Spain., Spain, 3Proteomic Research Service. Hospital Universitario San Cecilio., Spain, 4Bone Metabolic Unit (RETICEF). Endocrinology Division. Hospital Universitario San Cecilio., Spain, 5Bone Metabolic Unit., Spain, 6University Hospital, Spain Disclosures: Antonia Garcı´a-Martı´n, None

FR0409

RANKL Production by B Lymphocytes Contributes to the Bone Loss Induced by Inflammation and Ovariectomy Melda Onal*, Jinhu Xiong, Priscilla Cazer, Stavros Manolagas, Charles O’Brien. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Melda Onal, None

FR0410

Rapid Loss of Bone Mass and Strength after Non-bone Focal X-ray Irradiation in Growing Mice Peter Corry, Dan Jia*. University of Arkansas for Medical Sciences, USA Disclosures: Dan Jia, None

35

Friday

Bone Steatosis And Osteocyte Apoptosis In Alcohol-induced Bone Loss Delphine Maurel*1, Stephane Pallu2, Christelle Jaffre3, Nathalie Boisseau4, Nick Fazzalari5, Rustem Uzbekov6, Gael Rochefort7, Claude-Laurent Benhamou8. 1Inserm Unit 658, Hopital Porte Madeleine, Orle´ans, France, France, 2INSERM U 658 / University of Orle´ans, France, 3INSERM Unit U658, France, 4Laboratory of Physical Activity Biology, Blaise Pascal University, France, 5Institute of Medical & Veterinary Science, Australia, 6 Microscopy Department, Medical Faculty, Tours University, France, 7INSERM U658, France, 8INSERM Unit U658, CHR Orleans, France

FR0411

2011 ASBMR SHUN-ICHI HARADA YOUNG INVESTIGATOR AWARD Sclerostin and Risk of Hip Fracture in Older Women Aarthi Arasu*1, Peggy Cawthon2, Thy Do3, Puneet Arora4, Li-Yung Lui2, Jane Cauley5, Kristine Ensrud6, Steven Cummings 7. 1University of California, San Francisco, USA, 2 California Pacific Medical Center Research Institute, USA, 3Amgen, Inc., USA, 4Amgen, USA, 5University of Pittsburgh Graduate School of Public Health, USA, 6Minneapolis VA Medical Center / University of Minnesota, USA, 7San Francisco Coordinating Center, USA Disclosures: Aarthi Arasu, Amgen, 5

FR0413

Comparative Effects of Teriparatide and Risedronate in Glucocorticoid-Induced Osteoporosis in Men: 18-Month Results of the EuroGIOPS Trial. Claus-C Glu¨er*1, Fernando Marin2, Christian Graeff1, Jaime Pen˜a 3, Andreas Reisinger4, Helmut Petto5, Philippe Zysset4. 1Biomedical Imaging, Department of Diagnostic Radiology, UKSH, Germany, 2Lilly Research Center, United Kingdom, 3Biomedical Imaging. Department of Diagnostic Radiology, UKSH, Germany, 4Institute for Lightweight Design & Structural Biomechanics, Vienna University of Technology, Austria, 5 Lilly Research Center, Austria Disclosures: Claus-C Glu¨er, None

FR0414

Effects of Teriparatide on Cortical Histomorphometric Variables in Patients Receiving Longterm Alendronate Therapy Jan Stepan*1, Harald Dobnig2, Astrid Fahrleitner-Pammer3, Yanfei Ma4, Qing Zeng4, Xiaohai Wan5, Fernando Marin6, Imre Pavo7. 1Charles University, Czech Republic, 2 Department of Internal Medicine, Division of Endocrinology & Metabolism, Medical University of Graz, Austria, 3Medical University Graz, Austria, 4Eli Lilly & Company, USA, 5Lilly USA, LLC, USA, 6Eli Lilly & Company, Spain, 7Eli Lilly & Company, Austria Disclosures: Jan Stepan, None

FR0415

In Premenopausal Women with Idiopathic Osteoporosis, Baseline Bone Turnover Predicts Response to Teriparatide Adi Cohen*1, Emily Stein2, David Dempster 3, Hua Zhou4, Robert Recker5, Joan Lappe5, Chiyuan Zhang3, Donald McMahon2, Polly Chen3, Kavita Pandit3, Clifford Rosen6, Elizabeth Shane2. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA, 4Helen Hayes Hospital, USA, 5Creighton University Osteoporosis Research Center, USA, 6Maine Medical Center, USA Disclosures: Adi Cohen, None

FR0418

Teriparatide and Antiresorptive Combination Treatment subsequent to 9 Months of Teriparatide Monotherapy Christian Muschitz*1, Roland Kocijan2, Astrid Fahrleitner-Pammer3, Friederike Ku¨hne 4, Christina Bittighofer4, Angela Trubrich4, Reinhart Waneck5, Heinrich Resch6. 1St. Vincent’s Hospital, Austria, 2St.Vincent Hospital Vienna, Austria, 3Medical University Graz - division of Endocrinology & Metabolism, Department of Internal Medicine, Austria, 4The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 5St. Vincent Hospital - Department of Radiology, Austria, 6Medical University Vienna, Austria Disclosures: Christian Muschitz, None

FR0419

Teriparatide has Different Effects on Trabecular and Cortical Bone as Measured by 18FFluoride Positron Emission Tomography Michelle Frost*1, Musib Siddique1, Glen M. Blake1, Amelia EB. Moore1, Paul J. Schleyer1, Paul K Marsden1, Richard Eastell2, Ignac Fogelman3. 1King’s College London, United Kingdom, 2University of Sheffield, United Kingdom, 3Guy’s Hospital, United Kingdom Disclosures: Michelle Frost, Lilly, 2

FR0421

A Single Dose of Zoledronic Acid Prevents Periprosthetic Bone Loss in Female Patients with Cementless Total Hip Arthroplasty Hannu Aro*1, Niko Moritz1, Petteri Lankinen1, Satu Timlin2, Erkki Svedstro¨m 2. 1 University of Turku, Finland, 2Turku University Hospital, Finland Disclosures: Hannu Aro, Novartis, 2; Stryker Inc, 2; Novartis, 8

36

FR0423

Bisphosphonates and acute kidney injury. Safety signal identification in the Food and Drug Administration Adverse events reporting system (FDA AERS): A Report from the Research on Adverse Drug events And Reports (RADAR) Project Beatrice Edwards*1, Sarah Usmani2, Dennis Raisch3, June McKoy4, Steve Belknap5, Athena Samaras5, Dustin Liebling4, Jaimee Holbrook5, Craig Langman6, Ali Abu Alfa7, Dennis P. West 5. 1Northwestern University Medical School, USA, 2Northwestern UniversityHospital, USA, 3University of New Mexico College of Pharmacy, USA, 4 Northwestern University, Division of Geriatrics, USA, 5Northwestern University, Department of Dermatology, USA, 6Children’s Memorial Hospital, USA, 7Yale School of Medicine, Division of Nephrology, USA Disclosures: Beatrice Edwards, Dr. Edwards reports having served as a speaker for Eli Lilly and Company, Warner Chilcott, and Amgen., 8

FR0429

Long-Term Impact of Adherence to Oral Bisphosphonates on Osteoporotic Fracture Incidence John S. Sampalis*1, Jonathan Adachi2, Emmanouil Rampakakis3, Julie Vaillancourt3, Angela Karellis 3, Christian Kindundu4. 1McGill University & Jewish General Hospital, Canada, 2St. Joseph’s Hospital, Canada, 3JSS Medical Research, Canada, 4Novartis, Canada Disclosures: John S. Sampalis, JSS Medical Research, 4

FR0433

Disclosures: Jeffrey Curtis, Amgen, 2; Proctor and Gamble, 2; Roche, 2; Novartis, 5; Novartis, 2; Amgen, 5; Roche, 5; Merck, 5; Merck, 2; Eli Lilly, 5; Eli Lilly, 2 FR0438

Population-Based Trends in BMD Testing and Osteoporosis Treatment for New Initiations of Long-Term Systemic Glucocorticoids (1998-2008) Sumit Majumdar*1, Lisa M. Lix2, Colleen Metge3, Suzanne Morin4, Marina Yogendran3, William Leslie3. 1University of Alberta, Canada, 2University of Saskatchewan, Canada, 3 University of Manitoba, Canada, 4McGill University Health Centre, Canada Disclosures: Sumit Majumdar, None

FR0439

Predicting Adherence among Women Participating in the Global Longitudinal Registry of Osteoporosis in Women Jeffrey Curtis*1, Allison Wyman2, Gordon FitzGerald2, Adolfo Diez-Perez3, Stephen Gehlbach 4, Christian Roux5, Kenneth Saag1, Ethel Siris 6, Stuart Silverman7. 1University of Alabama at Birmingham, USA, 2University of Massachusetts Medical Center, USA, 3 Autonomous University of Barcelona, Spain, 4University of Massachusetts, USA, 5 Hospital Cochin, France, 6Columbia University College of Physicians & Surgeons, USA, 7 Cedars-Sinai/UCLA, USA Disclosures: Jeffrey Curtis, Merck, 5; Amgen, 2; Merck, 2; Eli Lilly, 5; Amgen, 5; Roche, 2; Roche, 5; Novartis, 2; Proctor and Gamble, 2; Novartis, 5; Eli Lilly, 2

FR0446

Discontinuation of Denosumab and Associated Fracture Incidence: Analysis From the FREEDOM Trial Jacques P. Brown*1, Jens-Erik Beck Jensen2, Nigel Gilchrist3, Chris Recknor 4, Christian Roux5, Ove Tørring6, Matt Austin7, Andrea Wang7, Andreas Grauer7, Rachel B. Wagman7. 1CHUQ-CHUL Research Centre, Canada, 2Hvidovre Hospital, Denmark, 3 Canterbury Geriatric Medical Research Trust, New Zealand, 4United Osteoporosis Centers, USA, 5Paris Descartes University, France, 6Karolinska Institutet So¨dersjukhuset, Sweden, 7Amgen Inc., USA Disclosures: Jacques P. Brown, Amgen Inc., Eli Lilly, Merck, Novartis, sanofi-aventis, Warner Chilcott,5; Abbott, Amgen Inc., Bristol-Myers Squibb, Eli Lilly, Merck, Novartis, Pfizer, Roche, sanofi-aventis, Servier and Warner Chilcott, 2; Amgen Inc., Eli Lilly, Novartis, 8

FR0448

Effect of a New Sustained-release Formulation of the Novel Cathepsin K Inhibitor, ONO5334, on Serum and Urine Biochemical Markers of Bone Turnover in Healthy Postmenopausal Women Shinichi Nagase1, Yoshitaka Hashimoto 2, Maria Small1, Mitchy Ohyama2, Junichiro Manako2, Tomohiro Kuwayama1, Stephen Deacon* 3. 1Ono Pharma UK Ltd, United Kingdom, 2Ono Pharmaceutical Co., Ltd., Japan, 3Ono Pharma, United Kingdom Disclosures: Stephen Deacon, Ono Pharma UK Ltd, 3

37

Friday

Adherence with Intravenous Zoledronic Acid and Ibandronate for Osteoporosis among U.S.Medicare Beneficiaries Jeffrey Curtis*, Huifeng Yun, Robert Matthews, Kenneth Saag, Elizabeth Delzell. University of Alabama at Birmingham, USA

FR0449

Effect of the Cathepsin K Inhibitor, ONO-5334, on Biochemical Markers of Bone Turnover in the Treatment of Postmenopausal Osteopenia or Osteoporosis: 2-Year Results from the OCEAN Study Richard Eastell*1, Shinichi Nagase2, Maria Small 2, Steven Boonen3, Tim Spector4, Tomohiro Kuwayama2, Stephen Deacon5. 1University of Sheffield, United Kingdom, 2 ONO PHARMA UK LTD, United Kingdom, 3Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 4King’s College London, United Kingdom, 5Ono Pharma, United Kingdom Disclosures: Richard Eastell, Warner Chilcott, 2; Amgen, 5; Inverness Medical, 5; Novartis, 5; Fonterra Brands, 5; Lilly, 5; Medtronics, 5; Ono Pharma, 5; Unilever, 5; AstraZeneca, 5; Amgen, 2; Nastech, 5; AstraZeneca, 2; Unipath, 5; GSK, 5; Past president ECTS, Member of MRC Efficacy and Mechanism Evaluation Board, 6; Sanofi Aventis, 5; Nestle, 5; Lilly, 2

FR0453

Treatment with the Cathepsin K Inhibitor Odanacatib in Postmenopausal Women with Low BMD: 5 Year Results of a Phase 2 Trial Neil Binkley*1, Henry Bone2, Nigel Gilchrist3, Bente Langdahl4, Heinrich Resch5, Jose Rodriguez-Portales6, Albert Leung7, Antonio Lombardi8, Celine Le Bailly De Tilleghem9, Carolyn DaSilva8, Elizabeth Rosenberg8, Andrew Denker8. 1University of Wisconsin, USA, 2Michigan Bone & Mineral Clinic, USA, 3Department of Orthopaedic Medicine & Surgery, Christchurch Hospital, New Zealand, 4Aarhus Sygehus, Aarhus University Hospital, Denmark, 5Medical University Vienna, Austria, 6Pontificia Universidad Cato´lica de Chile, Chile, 7Merck Research Laboratories, USA, 8Merck & Co., Inc., USA, 9Merck & Co., Inc., Belgium Disclosures: Neil Binkley, Merck, 2

FR0464

JTT-305 (MK-5442), an Orally Active Calcium-Sensing Receptor Antagonist, Stimulates Transient Parathyroid Hormone Release and Bone Formation Shuichi Kimura*, Takashi Nakagawa, Yoshihisa Okamoto, Yuji Ishida, Yushi Matsuo, Yuko Shinagawa, Mikio Hayashi. Central Pharmaceutical Research Institute, JAPAN TOBACCO INC., Japan Disclosures: Shuichi Kimura, JAPAN TOBACCO INC., 3

FR0465

Sclerostin Antibody Enhances Distraction Osteogenesis in Rats David Little*1, Oliver Birke1, Michelle McDonald1, Kathy Mikulec 1, Lauren Peacock1, Alyson Morse1, Min Liu2, Hua Zhu Ke3. 1The Children’s Hospital At Westmead, Australia, 2Amgen, USA, 3Amgen, Inc., USA Disclosures: David Little, Amgen Inc, 2

FR0466

The Tamoxifen Metabolite, Endoxifen, has Anabolic Actions on the Skeleton John Hawse*1, Malayannan Subramaniam 2, Muzaffer Cicek2, Kevin Pitel3, Kenneth Peters4, Sarah Grygo4, Xianglin Wu4, Glenda Evans2, James Ingle4, Matthew Goetz4, Thomas Spelsberg2. 1Mayo Clinic College of Medicine, USA, 2Mayo Clinic, USA, 3 University of Minnesota, USA, 4Mayo Clinic College of Medicine, USA Disclosures: John Hawse, None

FR0473

Differential Effects of Odanacatib and Alendronate on Bone Turnover in the Femoral Neck of Adult Ovariectomized Rhesus Monkeys Tara Cusick*1, Brenda Pennypacker2, Maureen Pickarski1, Le Thi Duong2. 1Merck & Co., Inc., USA, 2Merck Research Laboratories, USA Disclosures: Tara Cusick, Merck & Co., 3

FR0475

Inhibition of GSK3 Modulates Early Biomarkers of Bone Turnover in Rats Peter S Gilmour*1, Witte Koopmann 2, Hitesh Sanganee1, Hiroki Wada1, Ashwani Bahl 1, Stefan Kavanagh1, Peter A Hall1, Katherine Escott1. 1Astrazeneca R&D, United Kingdom, 2 AstraZeneca, Sweden Disclosures: Peter S Gilmour, None

38

FR0482

2011 ASBMR YOUNG INVESTIGATOR AWARD Altered Balance between Chondrocyte Apoptosis and Proliferation is Associated with Growth Plate Fusion in Mice with a Specific Inactivation of AF-1 in Estrogen Receptor (ER)-a while Total Inactivation of ERa Results in Prolonged and Enhanced Longitudinal Bone Growth Anna Borjesson*1, Sara Windahl2, Marie Lagerquist3, Cecilia Engdahl4, Elham Karimian5, Emma E Eriksson5, Maria Cristina Antal6, Andre´e Krust6, Pierre Chambon6, Lars Sa¨vendahl5, Claes Ohlsson 1. 1Centre for Bone & Arthritis Research, Sweden, 2Center for Bone & Arthritis Research, Sweden, 3Sahlgrenska University Hospital, Sweden, 4Centre for Bone & Arthritis Researc, GU, Sauhlgrenska Academy, Medicine, Sweden, 5Division of Pediatric Endocrinology, Department of Womens & Childrens Health, Karolinska Institutet, Sweden, 6Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire (CNRS, INSERM, UdS, Colle`ge de France), Illkirch, France Disclosures: Anna Borjesson, None

FR0483

Androgen Directly Exerts Anabolic Action through Osteoblastic Androgen Receptor Yuuki Imai*1, Min-Young Youn2, Min Ni 3, Kazuki Inoue1, Shino Kondoh1, Takahiro Matsumoto 4, Myles Brown3, Shigeaki Kato2. 1The University of Tokyo, Japan, 2University of Tokyo, Japan, 3Department of Medical Oncology, Dana-Farber Cancer Institute, USA, 4 Tokushima University, Japan Disclosures: Yuuki Imai, None

A Human BAC Transgene Containing the Vitamin D Receptor Gene Locus Humanizes the VDR-null Mouse and Rescues the Aberrant Biological Phenotype of VDR Deficiency Seong-Min Lee*1, Kathleen Bishop1, Charles O’Brien2, J. Pike1. 1University of WisconsinMadison, USA, 2University of Arkansas for Medical Science, USA Disclosures: Seong-Min Lee, None

FR0492

DNA Methylation Levels of CYP2R1 and CYP24A1 Predict Vitamin D Dose-response Variation Xiaojing Xu*1, Yu Zhou2, Fengxiao Bu2, An Ye 1, Boting Zhou1, Robert Recker1, Joan Lappe1, Lanjuan Zhao3. 1Creighton University Osteoporosis Research Center, USA, 2 Creighton University, USA, 3Creighton University Medical Center, USA Disclosures: Xiaojing Xu, None

FR0493

Enhanced Vitamin D Synthesis in Osteoblasts Protects Against Age-Related Bone Loss Paul Anderson*1, Andrew Turner2, Rebecca Sawyer1, Peter O’Loughlin3, Gerald Atkins4, Howard Morris2. 1Musculoskeletal Biology Research, University of South Australia, Australia, 2SA Pathology, Australia, 3Chemical Pathology, SA Pathology, Australia, 4 University of Adelaide, Australia Disclosures: Paul Anderson, None

MINORITY INVESTIGATOR RECEPTION Sponsored by the ASBMR Membership Development Committee 5:45 pm - 7:00 pm

Hall GH

This reception fosters interactivity by providing attendees with the opportunity to meet other attendees and ASBMR leadership, including the ASBMR Minority Subcommittee members. The Reception will be held concurrently with the Welcome Reception and the Plenary Poster Session in the Young Investigators Lounge adjacent to the ASBMR Networking Center in the Exhibit Hall of the San Diego Convention Center.

NEW INVESTIGATOR/NEW MEMBER/FIRST TIME ATTENDEE RECEPTION Sponsored by the ASBMR Membership Development Committee 5:45 pm - 7:00 pm

Hall GH

The ASBMR Membership Development Committee and Young Investigator Subcommittee members will be in attendance for this meet-and-greet networking event. The reception has been organized to promote interactions among young investigators and ASBMR leadership so that they may begin building a network of career-long contacts. The New Investigator/New Member/First-time Attendee

39

Friday

FR0487

Reception will be held concurrently with the Welcome Reception and the Plenary Poster Session in the Young Investigators Lounge adjacent to the ASBMR Networking Center in the Exhibit Hall at the San Diego Convention Center.

YOUNG INVESTIGATOR/MINORITY INVESTIGATOR NETWORKING HOUR Sponsored by the ASBMR Membership Development Committee 7:00 pm - 8:00 pm

Center Terrace

This cash bar event is open to Young Investigators and under-represented minority investigators who want to continue fostering new professional relationships in a fun and informal setting.

PEDIATRIC BONE AND MINERAL WORKING GROUP Emerging Treatments for Pediatric Bone and Mineral Disorders Supported by an Educational Grant from Enobia Pharma Ticket Required 7:15 pm - 9:30 pm

Room 33ABC

7:15 pm

Opening Remarks and Dinner

7:40 pm

Lithium in Osteoporosis-Psuedoglioma Syndrome Elizabeth Streeten, BA, M.D. University of Maryland School of Medicine, USA

8:00 pm

PTH 1-34 in Hypoparathyrodisim Rachel Gafni, M.D. NIDCR National Institutes of Health, USA

8:20 pm

Recombinant TNALP in Hypophosphatasia Michael Whyte, M.D. Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, USA

8:40 pm

Emerging Therapies in Hypophosphatemic Rickets Erik Imel, BS, M.D. Indiana University School of Medicine Division of Endocrinology and Metabolism Department of Internal Medicine & Pediatric Endocrinology/Diabetology Section Department of Pediatrics Indianapolis, USA

9:00 pm

Whole Body Vibration Training in Pediatric Osteoporosis Amy DiVasta, M.D. Harvard Medical School Staff Physician, Divisions of Adolescent Medicine and Pediatric/ Adolescent Gynecology Children’s Hospital Boston, USA

9:20 pm

Concluding Remarks

Disclosures: Dr Elizabeth Streeten – Nothing to disclose. Dr Rachel Gafni – Nothing to disclose. Dr. Michael Whyte – Enobia Pharma, Inc 2, 5. Dr. Erik Imel – Kyowa Hakko Kirin, Pharma 2. Dr Amy Divasta – Nothing to disclose.

WORKING GROUP ON SKELETAL AGING Skeletal Stem Cell Aging Ticket Required 7:15 pm - 9:15 pm

Room 30AB

Program Moderator will be selected from among the working group organizers: Bernard P. Halloran, Ph.D., Veterans Affairs Medical Center University of California San Francisco, USA Julie Glowacki, Ph.D., Brigham and Women’s Hospital Boston, USA

40

Robert J. Pignolo, M.D., Ph.D., University of Pennsylvania, USA Sherry S. Sherman, Ph.D., National Institute on Aging U.S. National Institutes of Health, USA Dinner/Opening remarks by organizers

7:30 pm

Aging and Osteoblast Regulation of the Bone Marrow HSC Niche Bernard P. Halloran, Ph.D. Veterans Affairs Medical Center and the University of California, USA

7:50 pm

Questions/Discussion

8:00 pm

Changes in the Distribution and Function Marrow Fat with Aging Beata Lecka-Czernik, Ph.D. University of Toledo, USA

8:20 pm

Questions/Discussion

8:30 pm

Senescence-associated Intrinsic Mechanisms of Osteoblast Dysfunctions Moustapha Kassem, M.D., Ph.D. University Hospital of Odense, Denmark, and College of Medicine, King Saud University, KSA

8:50 pm

Questions/Discussion

9:00 pm

Closing remarks by organizers

Friday

7:15 pm

Disclosures: Bernard Halloran, None; Beata Lecka-Czernik, None; Moustapha Kassem, None

IN VIVO WORKING GROUP The Effects of Neuropeptides on Bone: How Important Are They? Sixteenth Annual Meeting Ticket Required 7:15 pm - 9:15 pm

Room 30CDE

7:15 pm Buffet Dinner 7:45 pm

Sympathetic Innervation of Bone: Facts and Biological Relevance Florent Elefteriou, Ph.D. Department of Medicine Vanderbilt University, USA

8:15 pm

Neuropeptide Y: A Finger in Every Pie Edith Gardiner, Ph.D. Department of Orthopaedics and Sports Medicine University of Washington, USA

8:45 pm

Mice Lacking Substance P Have Diminished Bone Formation, Increased Resorption, Delayed Bone Healing, and Accelerated Osteopenia With Aging Wade Kingery, M.D. VA Palo Alto Health Care System, USA

Disclosures: Dr. Florent Elefteriou – None. Dr. Edith Gardiner – None. Dr. Wade Kingery – None. Dr. Donald Kimmel – Amgen, 5; Lexicon Pharmaceuticals, 5; Xradia, 5. Dr. Thomas Wronski – Amgen, 2; Lexicon Pharmaceuticals, 2.

MUSCLE AND BONE WORKING GROUP The Muscle and Bone Relationship: From Young to Old Ticket Required 7:15 pm - 9:45 pm

Room 32AB

Chairs: Lora Giangregorio, Ph.D. University of Waterloo, Canada Saija Kontulainen, Ph.D. University of Saskatchewan, Canada Program: 7:15 pm Box Dinner

41

7:25 pm

Opening Remarks

7:30 pm

Exercise Loading and Femoral Neck Geometry Harri Sievanen, ScD. UKK Institute, Tampere, Finland

8:20 pm

Muscle Density, Bone Structure and Falls in the Elderly: Evidence from the Saskatoon CaMos Cohort Andrew Frank, MSc. University of Saskatchewan, Canada

8:40 pm

Evaluation of the Muscle-bone Unit Theory among Individuals with Chronic Spinal Cord Injury Lora Giangregorio, Ph.D. University of Waterloo, Canada

9:00 pm

Clinical Application of Mechanography Rainer Rawer Novotec Medical, Germany

9:30 pm

Closing Remarks

Disclosures: Dr. Lora Giangregorio – Nothing to disclose; Dr. Saija Kontulainen – Nothing to disclose; Dr. Harri Sievanen – Nothing to disclose; Andrew Frank – Nothing to disclose; Rainer Rawer – Novotec Medical; Dr Christopher Gordon – Orthometrix lnc., 5.

42

Saturday, September 17, 2011

SATURDAY, SEPTEMBER 17, 2011 DAY-AT-A-GLANCE Time/Event/Location

All locations in the San Diego Convention Center unless otherwise noted

6:45 am - 8:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 ASBMR Networking Breakfast Room 33ABC 7:00 am - 5:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 ASBMR Registration Open Hall F 8:00 am - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Posters Open Hall GH 8:00 am - 9:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Louis V. Avioli Memorial Lecture - Osteocytes - The Great Communicators Room 20BCD

9:00 am - 9:05 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Presentation of the ASBMR Gideon A. Rodan Excellence in Mentorship Award Room 20BCD 9:05 am - 9:10 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Presentation of the ASBMR Lawrence G. Raisz Award Room 20BCD 9:10 am - 9:30 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Coffee Break Hall GH 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 Concurrent Oral Session 01: Osteoblasts Room 29ABCD 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 Concurrent Oral Session 02: Bone, Cartilage and Connective Tissue Matrix Room 30CDE 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Concurrent Oral Session 03: Genetic Disorders of Bone Room 32AB 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Concurrent Oral Session 04: Osteoporosis Epidemiology: Biomarkers for Fracture Room 20A 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 Concurrent Oral Session 05: New Approaches to Osteoporosis Treatment (Preclinical) Room 31ABC 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Concurrent Oral Session 06: John H. Carsten’s Memorial Session for Osteoporosis Room 20BCD

43

Saturday

9:00 am - 4:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Exhibits Open Hall GH

10:00 am - 11:00 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Meet-the-Professor Sessions Room 25A - Room 25C 11:00 am - 1:00 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Poster Session I & Poster Tours Hall GH 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116 Special Lecture on Sarcopenia Room 31ABC 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 116 Meet-the-Professor Sessions Room 24A - Room 27A 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 Career Development: Building Interdisciplinary Collaboration in Research Room 32AB 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 Clinical Roundtable/Case Conference - Anabolic Agents for Fracture Repair Room 20BCD 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 Concurrent Oral Session 07: Osteocytes Room 29ABCD 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Concurrent Oral Session 08: Osteoclasts Room 30CDE 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 120 Concurrent Oral Session 09: Calciotropic and Phosphotropic Hormones Room 31ABC 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 Concurrent Oral Session 10: Osteoporosis Assessment: Prediction of Fracture Risk Room 20A 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122 Concurrent Oral Session 11: Osteoporosis Treatment (Clinical): Anti-resorptive Treatment Room 20BCD 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Concurrent Oral Session 12: Bone Biomechanics and Quality: Animal Models Room 32AB 3:30 pm - 4:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124 Coffee Break Hall GH 4:00 pm - 5:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124 Clinical Update for Health Professionals Room 20BCD 4:00 pm - 5:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 State-of-the-Art Lectures – Bone-Hematopoietic Interactions Room 20A 5:30 pm - 8:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 Clinical Evening at ASBMR Manchester Grand Hyatt Randle Ballroom (4th Level) 8:30 pm - 11:30 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 ASBMR Social Event - California Dreamin’ Manchester Grand Hyatt Elizabeth Ballroom and Terrace (2nd Level) Ticket Required

44

ASBMR NETWORKING BREAKFAST Sponsored by the ASBMR Membership Development Committee 6:45 am - 8:00 am

Room 33ABC

New Investigators (early-career stage), new ASBMR members and young and underrepresented minority investigators are invited to join the ASBMR Membership Development Committee and colleagues for an informational breakfast. New Investigators and first-time attendees are encouraged to pick up a "New Investigator" or "First-time Attendee" ribbon, which will be distributed at the entrance to the room. Breakfast will be provided.

ASBMR REGISTRATION OPEN 7:00 am - 5:30 pm

Hall F

POSTERS OPEN 8:00 am - 6:00 pm

Hall GH

LOUIS V. AVIOLI MEMORIAL LECTURE - OSTEOCYTES - THE GREAT COMMUNICATORS Supported by an Educational Grant from Lilly USA, LLC Room 20BCD

Chair Sundeep Khosla, M.D. College of Medicine, Mayo Clinic, USA Disclosures: Sundeep Khosla, None

8:00 am

Osteocytes - The Great Communicators Lynda F. Bonewald, Ph.D. University of Missouri - Kansas City, USA Disclosures: Lynda Bonewald, None

EXHIBITS OPEN 9:00 am - 4:00 pm

Hall GH

PRESENTATION OF THE ASBMR GIDEON A. RODAN EXCELLENCE IN MENTORSHIP AWARD 9:00 am - 9:05 am

Room 20BCD

PRESENTATION OF THE ASBMR LAWRENCE G. RAISZ AWARD 9:05 am - 9:10 am

Room 20BCD

COFFEE BREAK 9:10 am - 9:30 am

Hall GH

45

Saturday

8:00 am - 9:00 am

CONCURRENT ORAL SESSION 01: OSTEOBLASTS 9:30 am - 11:00 am

Room 29ABCD

Moderators: Gerard Karsenty, M.D., Ph.D. Columbia University, USA Disclosures: Gerard Karsenty, None

Douglas Digirolamo, Ph.D. Johns Hopkins University, USA Disclosures: Douglas Digirolamo, None

9:30 am 1001

Mice Lacking Tuberous Sclerosis 2 in Osteoblasts Develop Insulin Resistance with Increased Bone and Fat Mass Ryan Riddle*1, Julie Leslie2, Douglas Digirolamo2, Thomas Clemens2. 1Johns Hopkins University School of Medicine, USA, 2Johns Hopkins University, USA Disclosures: Ryan Riddle, None

9:45 am 1002

Neuropeptide Y Receptor Signaling in Osteoblasts is Required for Normal Glucose Homeostasis in Mice Nicola Lee1, Daniela Sousa2, Ronaldo Enriquez3, Amanda Sainsbury 3, Herbert Herzog3, Paul Baldock*1. 1Garvan Institute of Medical Research, Australia, 2INEB - Instituto de Engenharia Biome´dica, Portugal, 3Garvan Institute, Australia Disclosures: Paul Baldock, None

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1003 Altering AP-1 Transcription via DFosB in the Hypothalamus Regulates Bone and Energy Homeostasis through the ARC and VMH Nuclei, Respectively Kazusa Sato*1, Glenn C Rowe2, Min Yin1, Hiroaki Saito1, Sutada Lotinun1, William Horne1, Roland Baron3. 1Harvard School of Dental Medicine, USA, 2Beth Israel Deaconess Medical Center, USA, 3Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, & Harvard School of Dental Medicine, USA Disclosures: Kazusa Sato, None

10:15 am Reduced Peripheral Leptin Signaling Drastically Decreases Bone Formation 1004 Urszula Iwaniec*, Carmen P. Wong, L. Bailey Lindenmaier, Kenneth Philbrick, Dawn Olson, Russell Turner. Oregon State University, USA Disclosures: Urszula Iwaniec, None

10:30 am In vivo Fate Mapping identifies Mesenchymal Progenitor Cells 1005 Danka Grcevic1, Slavica Pejda2, Dario Repic3, Liping Wang3, Haitao Li 3, Mark Kronenberg 3, Peter Maye3, Douglas Adams3, David Rowe3, Hector Aguila3, Ivo Kalajzic* 3. 1University of Zagreb, Croatia, 2University of Connecticut, USA, 3University of Connecticut Health Center, USA Disclosures: Ivo Kalajzic, None

10:45 am Nestin as a Marker for Bone Marrow Mesenchymal Stem Cells 1006 Xiaoli Zhao*1, Bing Yu1, Lingling Xian2, William Lu3, Mei Wan4, Xu Cao1. 1Johns Hopkins University, USA, 2Johns Hopkins University School of Medicine, USA, 3The University of Hong Kong, Hong Kong, 4Johns Hopkins University School of Medicine, USA Disclosures: Xiaoli Zhao, None

CONCURRENT ORAL SESSION 02: BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX 9:30 am - 11:00 am Moderators: Majd Zayzafoon, M.D., Ph.D. University of Alabama at Birmingham, USA Disclosures: Majd Zayzafoon, None

46

Room 30CDE

Andre J. Van Wijnen, Ph.D. University of Massachusetts Medical School, USA Disclosures: Andre Van Wijnen, None

9:30 am 1007

2011 ASBMR SHUN-ICHI HARADA YOUNG INVESTIGATOR AWARD A Y Chromosome Gene, Uty, Defines Sexual Dimorphism in Skeletal Phenotype Kazuki Inoue*1, Yuuki Imai1, Shigeaki Kato2. 1The University of Tokyo, Japan, 2 University of Tokyo, Japan Disclosures: Kazuki Inoue, None

9:45 am 1008

Transcriptional Coregulator Jab1 Is Essential for Chondrocyte Differentiation in vivo Dongxing Chen1, Bojian Liang1, Martina Panattoni 2, Keiko Tamai 1, Ruggero Pard2, Brendan Lee3, Guang Zhou*1. 1Case Western Reserve University, USA, 2Scientific Institute San Raffaele, Italy, 3Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Guang Zhou, None

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1009 Notch/Rbpj/Hes1 Signal in Chondrocytes Modulates the Terminal Stage of Endochondral Ossification during Skeletal Growth and Osteoarthritis Development Yoko Hosaka*1, Taku Saito1, Shurei Sugita1, Atsushi Fukai1, Tomohiro Hikata2, Haruhiko Akiyama3, Takashi Nakamura 3, Kozo Nakamura 4, Ung-Il Chung5, Hiroshi Kawaguchi6. 1University of Tokyo, Graduate School of Medicine, Japan, 2Keio University School of Medicine, Japan, 3Kyoto University, Japan, 4The University of Tokyo, Japan, 5 University of Tokyo Graduate Schools of Engineering & Medicine, Japan, 6University of Tokyo, Faculty of Medicine, Japan Disclosures: Yoko Hosaka, None

Disclosures: Stefano Zanotti, None

10:30 am C/EBP-b and RUNX2 Cooperatively Control Cartilage Degradation with MMP-13 as the 1011 Target and HIF-2a as the Inducer in Chondrocytes Makoto Hirata*1, Fumitaka Kugimiya2, Atsushi Fukai3, Taku Saito4, Akihiko Mabuchi3, Bishwa Raj Sapkota3, Toru Akune3, Fumiko Yano1, Toshiyuki Ikeda3, Nao Nishida3, Noriko Yoshimura 5, Takumi Nakagawa3, Kozo Nakamura 1, Katsushi Tokunaga6, Ung-Il Chung7, Hiroshi Kawaguchi 6. 1The University of Tokyo, Japan, 2Sensory & Motor System Medicine, University of Tokyo, Japan, 3University of Tokyo, Japan, 4University of Tokyo, Graduate School of Medicine, Japan, 522nd Century Medical & Research Center, University of Tokyo, Japan, 6University of Tokyo, Faculty of Medicine, Japan, 7University of Tokyo Graduate Schools of Engineering & Medicine, Japan Disclosures: Makoto Hirata, None

10:45 am Two Major microRNA Species in Chondrocytes, miR-140 and let-7 miRNAs, Regulate 1012 Endochondral Bone Growth through Distinct Mechanisms. Jennifer Inloes*, Tatsuya Kobayashi. Massachusetts General Hospital, USA Disclosures: Jennifer Inloes, None

CONCURRENT ORAL SESSION 03: GENETIC DISORDERS OF BONE 9:30 am - 11:00 am

Room 32AB

Moderators: Wim Van Hul, Ph.D. University of Antwerp, Belgium Disclosures: Wim Van Hul, None

Deborah Wenkert, M.D. Amgen, Inc., USA Disclosures: Deborah Wenkert, None

47

Saturday

10:15 am Notch Inhibits Nuclear Factor of Activated T-Cells (NFAT) Transactivation in Primary 1010 Epiphyseal Chondrocytes In Vitro. Stefano Zanotti*, Maria Monarca, Ernesto Canalis. St. Francis Hospital & Medical Center, USA

9:30 am 1013

2011 ASBMR YOUNG INVESTIGATOR AWARD Targeting the TGF-b/Smad Pathway in Neurofibromatosis Type 1 Skeletal Defects Steven Rhodes*1, Yongzheng He1, Xiaohua Wu 1, Lisa Hong Chen1, Ping Zhang2, Shi Chen1, Chang Jiang3, Hiroki Yokota3, Xianghong Peng1, Khalid Mohammad1, Theresa Guise1, Feng-Chun Yang1. 1Indiana University, USA, 2Indiana University School of Medicine, USA, 3Indiana University Purdue University Indianapolis, USA Disclosures: Steven Rhodes, None

9:45 am 1014

2011 ASBMR YOUNG INVESTIGATOR AWARD Plekhm1 is Essential for Bone Resorption in Mice and Regulates Cathepsin K Secretion through Linking Lysosomes to Microtubules in Osteoclasts Shiqiao Ye*1, Kai Liang2, Yi-Ping Li3, Stavros Manolagas1, Haibo Zhao1. 1University of Arkansas for Medical Sciences, USA, 2Department of Dermatology, University of Arkansas for Medical Sciences, USA, 3University of Alabama at Birmingham, USA Disclosures: Shiqiao Ye, None

10:00 am Increased Osteoclast Formation and Bone Resorption in the Brtl Osteogenesis Imperfecta 1015 Mouse Occur through Marrow Mesenchymal Stromal Cell and Abnormal Matrix Dependent Mechanisms Patricia Collin-Osdoby*1, Linda Rothe1, Matthew Kwong1, Wayne Cabral2, Rajeev Aurora3, Joan C. Marini4, Philip Osdoby1. 1Washington University in St. Louis, USA, 2 NIH, NICHD, USA, 3St Louis University, USA, 4NIH NIHCD, USA Disclosures: Patricia Collin-Osdoby, None

10:15 am The V-ATPase a3 Subunit Mutation R740S Results in Osteoclast Apoptosis Due to 1016 Uncoupled ATP Hydrolysis in Homozygous Mice Noelle Ochotny*1, Ann Flenniken2, Celeste Owen3, Irina Voronov1, Morris Manolson4, Jane Aubin5. 1University of Toronto, Canada, 2Centre for Modeling Human Disease, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada, 3Centre for Modeling Human Disease, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Canada, 4 University of Toronto, Can, 5University of Toronto Faculty of Medicine, Canada Disclosures: Noelle Ochotny, None

10:30 am Embryonic Loss of Cytochrome P450 Reductase in Mice Results in Antley-Bixler Syndrome1017 Like Craniofacial and Bone Mass Defects Satya Panda*1, Anyonya Guntur2, Rekha Kar3, Kejian Tang1, Bettie Sue Masters1. 1 UTHSCSA, USA, 2Maine medical center research institute, USA, 3The University of Texas Health Science Center, USA Disclosures: Satya Panda, None

10:45 am BMN 111, a CNP Analogue, Promotes Skeletal Growth and Rescues Dwarfism In Two 1018 Transgenic Mouse Models of Fgfr3-related Chondrodysplasia Florence Lorget*1, Nabil Kaci2, Jeff Peng1, Catherine Benoist2, Federico Di Rocco2, Emilie Mugniery2, Sherry Bullens1, Stuart Bunting1, Laurie Tsuruda1, Charles O’Neill1, Arnold Munnich 2, Laurence Legeai-Mallet2. 1Biomarin Pharmaceutical Inc, USA, 2INSERM U781 - Universite Paris Descartes, Hopital Necker, France Disclosures: Florence Lorget, BioMarin, 3

CONCURRENT ORAL SESSION 04: OSTEOPOROSIS EPIDEMIOLOGY: BIOMARKERS FOR FRACTURE 9:30 am - 11:00 am Moderators: Margaret L. Gourlay, M.D., MPH University of North Carolina, USA Disclosures: Margaret Gourlay, None

Thomas F. Lang, Ph.D. University of California, San Francisco, USA Disclosures: Thomas Lang, None

48

Room 20A

9:30 am 1019

Inflammatory Markers and the Risk of Hip and Spine Fractures in Older Men: MrOS Jane Cauley*1, Yona Keich Cloonan2, Michelle Danielson2, Kristine Ensrud3, Howard Fink4, Eric Orwoll5, Robert Boudreau2. 1University of Pittsburgh Graduate School of Public Health, USA, 2University of Pittsburgh, USA, 3Minneapolis VA Medical Center / University of Minnesota, USA, 4GRECC, Minneapolis VA Medical Center, USA, 5Oregon Health & Science University, USA Disclosures: Jane Cauley, None

9:45 am 1020

Serum OPG and sRANKL Levels and Incident Hip Fracture in the Women’s Health Initiative Andrea LaCroix*1, Rebecca Jackson2, Aaron Aragaki1, Charles Kooperberg 1, David Duggan3. 1Fred Hutchinson Cancer Research Center, USA, 2The Ohio State University, USA, 3Translational Genomics Research Institute, USA Disclosures: Andrea LaCroix, None

10:00 am High Sensitive CRP Is an Independent Risk Factor for Fractures in Elderly Men: The MrOS 1021 Sweden Study Sofia Moverare Skrtic*1, Anna-Lena Eriksson 2, Osten Ljunggren3, Magnus Karlsson4, Dan Mellstrom5, Claes Ohlsson 6. 1Center for Bone & Arthritis Research at the Sahlgrenska Academy, Sweden, 2University of Gothenburg, Sweden, 3Uppsala University Hospital, Sweden, 4Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 5Sahlgrenska University Hospital, Sweden, 6Centre for Bone & Arthritis Research, Sweden Disclosures: Sofia Moverare Skrtic, None

10:15 am The Effects of Adiponectin and Leptin on Changes in Bone Mineral Density of the Hip 1022 Kamil Barbour*. , USA Disclosures: Kamil Barbour, None

Disclosures: Kristine Ensrud, None

10:45 am Clinical Characteristics of Women Who Fracture Despite Anti-Osteoporosis Medication. The 1024 Global Longitudinal Study of Osteoporosis in Women Adolfo Diez-Perez*1, Philip Sambrook2, Juliet Compston 3, Jonathan Adachi4, Frederick Hooven5, Nelson Watts6, Stuart Silverman7, Susan Greenspan8, Cyrus Cooper9, Steven Boonen10, Allison Wyman11, Stephen Gehlbach 12. 1Autonomous University of Barcelona, Spain, 2Royal North Shore Hospital, Australia, 3University of Cambridge School of Clinical Medicine, United Kingdom, 4St. Joseph’s Hospital, Canada, 5University of Massachusetts Medical School, USA, 6University of Cincinnati Bone Health & Osteoporosis Center, USA, 7Cedars-Sinai/UCLA, USA, 8University of Pittsburgh, USA, 9 University of Southampton, United Kingdom, 10Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 11UMass Medical School, USA, 12University of Massachusetts, USA Disclosures: Adolfo Diez-Perez, None

49

Saturday

10:30 am Serum Cystatin C and Risk of Hip Fractures in Older Women 1023 Kristine Ensrud*1, Neeta Parimi2, Yelena Slinin3, Teresa Hillier4, Jane Cauley5, Michael Steffes6, Steven Cummings 7. 1Minneapolis VA Medical Center / University of Minnesota, USA, 2California Pacific Medical Center Research Institute, USA, 3Univeristy of Minnesota / VA Medical Center, USA, 4Kaiser Center for Health Research, USA, 5 University of Pittsburgh Graduate School of Public Health, USA, 6Univeristy of Minnesota, USA, 7San Francisco Coordinating Center, USA

CONCURRENT ORAL SESSION 05: NEW APPROACHES TO OSTEOPOROSIS TREATMENT (PRECLINICAL) 9:30 am - 11:00 am

Room 31ABC

Moderators: Diane Gesty-Palmer, Ph.D., M.D. Duke University, USA Disclosures: Diane Gesty-Palmer, None

Lorenz C. Hofbauer, M.D. Dresden University Medical Center, Germany Disclosures: Lorenz Hofbauer, None

9:30 am 1025

LLP2A-Alendronate, a Novel Compound That Directs Mesenchymal Stem Cells to Bone, Prevents Bone Losses Induced By Aging or Ovariectomy Min Guan*1, Nancy Lane2, Ruiwu Liu 3, Kit Lam3, Liping Meng3, Junjing Jia 2, Brian Panganiban 4, Robert Ritchie 4, Wei Yao2. 1Department of Internal Medicine, University of California at Davis Medical Center, USA, 2University of California, Davis Medical Center, USA, 3Department of Biochemistry & Molecular Medicine, University of California at Davis Medical Center, USA, 4Department of Materials Science & Engineering, University of California at Berkeley, USA Disclosures: Min Guan, None

9:45 am 1026

2011 ASBMR YOUNG INVESTIGATOR AWARD Therapeutic RNAi targeting CKIP-1 for Promoting Bone Formation in an Aged Rat Model of Postmenopausal Osteoporosis Baosheng Guo*1, Baoting Zhang2, Heng WU1, Tao Tang3, Yixin He4, Gang Li 3, Leungkim Hung1, Fuchu He5, Lingqiang Zhang5, Ling Qin1, Ge Zhang1. 1Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, 2Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 3The Chinese University of Hong Kong, Hong Kong, 4The Cuinese University of Hong Kong, Hong Kong, 5State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China, China Disclosures: Baosheng Guo, None

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1027 A Delivery System Specifically Approaching Bone Formation Surfaces To Facilitate Translating RNAi-based Anabolic Therapy Ge Zhang*1, Baosheng Guo 2, Heng Wu 3, Tao Tang4, Baoting Zhang5, Leungkim Hung3, Fuchu He 6, Lingqiang Zhang6, Ling Qin3. 1Prince of Wales Hospital, Hong Kong, 2Prince of Wales Hospital, Hong Kong, 3Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China, Hong Kong, 4The Chinese University of Hong Kong, Hong Kong, 5Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 6State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China, China Disclosures: Ge Zhang, None

10:15 am A Combined Fc-OPG/hPTH(1-34) Therapy to Restore Impaired Skeletal Growth and Bone 1028 Loss in a Mouse Model of IL-6 Dependent Juvenile Inflammatory Diseases Andrea Del Fattore*1, Marta Capannolo 2, Barbara Peruzzi2, Alfredo Cappariello1, Nadia Rucci2, Fabrizio De Benedetti 1, Anna Teti2. 1Children Hospital Bambino Gesu`, Italy, 2 University of L’Aquila, Italy Disclosures: Andrea Del Fattore, None

10:30 am The Impaired Anabolic Effect of PTH In the Absence of Endogenous FGF2 Is Partially Due 1029 to Reduced ATF4 Expression Yurong Fei*1, Liping Xiao1, Thomas Doetschman2, Douglas Coffin3, Marja Marie Hurley4. 1University of Connecticut Health Center, USA, 2University of Arizona, USA, 3 The University of Montana, USA, 4University of Connecticut Health Center School of Medicine, USA Disclosures: Yurong Fei, None

50

10:45 am Efficacy of the Combination of Parathyroid Hormone plus Odanacatib or Alendronate, as 1030 compared to the Monotherapies in Estrogen-Deficient Rabbits. Brenda Pennypacker*1, Guoxin Wu2, Rachel Korn2, Rana Samadfam3, Susan Y. Smith3, Le Thi Duong1. 1Merck Research Laboratories, USA, 2Merck & Co., Inc., USA, 3Charles River Laboratories, Canada Disclosures: Brenda Pennypacker, None

CONCURRENT ORAL SESSION 06: JOHN H. CARSTEN’S MEMORIAL SESSION FOR OSTEOPOROSIS 9:30 am - 11:00 am

Room 20BCD

Moderators: Byron Lawrence Riggs, M.D. Mayo Clinic, USA Disclosures: Byron Riggs, None

Suzanne M. Cadarette, Ph.D. University of Toronto, Canada Disclosures: Suzanne Cadarette, None

9:30 am 1031

2011 ASBMR MOST OUTSTANDING CLINICAL ABSTRACT AWARD Heart Failure is a Clinically and Densitometrically Independent and Novel Risk Factor for Major Osteoporotic Fractures: Population-Based Cohort Study of 45,509 Subjects Sumit Majumdar*1, Justin A. Ezekowitz 1, Lisa M. Lix2, William Leslie 3. 1University of Alberta, Canada, 2University of Saskatchewan, Canada, 3University of Manitoba, Canada Disclosures: Sumit Majumdar, None

A Screening Programme for Identification of Vertebral Fractures Increases Bisphosphonate Prescribing and Reduces Fractures: Results of a Large RCT Emma Clark*, Leigh Morrison, Miranda Cuming, Virginia Gould, Jon Tobias. University of Bristol, United Kingdom Disclosures: Emma Clark, None

10:00 am Persistent Skeletal Exposure to Bone Morphogenetic Proteins is Detrimental and Causes 1033 Osteopenia Ernesto Canalis*1, Lisa Brunet2, Kristen Parker3, Stefano Zanotti1. 1St. Francis Hospital & Medical Center, USA, 2University of California, USA, 3Saint Francis Hospital & Medical Center, USA Disclosures: Ernesto Canalis, None

10:15 am 2011 ASBMR PRESIDENT’S AWARD 1034 Brown Fat Regulates Bone Mass Through Modulation of Sympathetic Tone Katherine Motyl*1, Masanobu Kawai2, Sheila Bornstein2, Victoria Demambro1, Leeann Louis3, Sutada Lotinun4, Mark Horowitz5, Roland Baron6, Mary Bouxsein3, Clifford Rosen2. 1Maine Medical Center Research Institute, USA, 2Maine Medical Center, USA, 3 Beth Israel Deaconess Medical Center, USA, 4Harvard School of Dental Medicine, USA, 5 Yale University School of Medicine, USA, 6Harvard School of Medicine & of Dental Medicine, USA Disclosures: Katherine Motyl, None

10:30 am Unexpected Enhanced Response to Mechanical Loading of Mice Lacking Cx43 Exclusively in 1035 Osteocytes Nicoletta Bivi*1, Nathan Farlow2, Lucas Brun3, Jeffrey Benson2, Keith Condon2, Alexander Robling1, Teresita Bellido2, Lilian Plotkin2. 1Indiana University, USA, 2Indiana University School of Medicine, USA, 3University of Rosario, Argentina Disclosures: Nicoletta Bivi, None

51

Saturday

9:45 am 1032

10:45 am High Body Mass Index, Adjusted for BMD, Is a Risk Factor for Fracture in Women 1036 Helena Johansson* 1, John Kanis2, Anders Oden1, Eugene McCloskey3, R Chapurlat4, C Christiansen5, S Cummings 6, Adolfo Diez-Perez7, John Eisman8, Saeko Fujiwara9, Claus-C Glueer10, Didier Hans11, K-T Khaw12, Marc-Antoine Krieg 13, Heikki Kroger14, Andrea La Croix15, Edith Lau16, William Leslie 17, Dan Mellstrom 18, L. Joseph Melton19, Terry O’Neill20, Julie Pasco21, J Prior22, David Reid23, Fernando Rivadeneira 24, David Torgerson 25, Tjeerd vanStaa26, Noriko Yoshimura27, M Zillikens28. 1University of Gothenburg, Sweden, 2University of Sheffield, Belgium, 3University of Sheffield, United Kingdom, 4Lyon Hospital, France, 5NordicBioscience, Denmark, 6University of San Francisco, USA, 7Autonomous University of Barcelona, Spain, 8Garvan Institute of Medical Research, Australia, 9Radiation Effects Research Foundation, Japan, 10Christian Albrechts Universitaet zu Kiel, Germany, 11Lausanne University Hospital, Switzerland, 12 Cambridge University, United Kingdom, 13University Hospital, Switzerland, 14Kuopio University Hospital, Finland, 15Women’s Health Initiative, United Kingdom, 16Hong Kong Orthopaedic & Osteoporosis Center for Treatment & Research, Hong Kong, 17University of Manitoba, Canada, 18Sahlgrenska University Hospital, Sweden, 19Mayo Clinic, USA, 20 University of Manchester, United Kingdom, 21Deakin University, Australia, 22Hospital, Canada, 23University of Aberdeen, United Kingdom, 24Erasmus University Medical Center, The Netherlands, 25University of York, United Kingdom, 26MHRA, United Kingdom, 2722nd Century Medical & Research Center, University of Tokyo, Japan, 28 Erasmus MC Rotterdam, The Netherlands Disclosures: Helena Johansson, None

MEET-THE-PROFESSOR SESSIONS 10:00 am - 11:00 am

Rooms 25A-25C

Managing Bone Loss in Anorexia Nervosa This session will be repeated on Sunday, September 18 at 1:00 pm Room 25A Supported by an educational grant from Merck & Co., Inc. Anne Klibanski, M.D. Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Anne Klibanski, None

Using Bone Markers in Clinical Practice This session will be repeated on Sunday, September 18 at 1:00 pm Room 25B Richard Eastell, M.D., FRCP University of Sheffield, United Kingdom Disclosures: Richard Eastell, IDS 5

Premenopausal Bone Loss This session will be repeated on Sunday, September 18 at 1:00 pm Room 25C Robert R. Recker, M.D. Creighton University Osteoporosis Research Center, USA Disclosures: Robert Recker, Novartis 2; Procter & Gamble 5; Glaxo Smith Kline 5; Novartis 5; NPS Allelix 5; Merck 2; Wyeth 5; Merck 5; Lilly 5; Roche 2; Amgen 2; Sanofi-Aventis 2; NPS Allelix 2; Procter & Gamble 2; Roche 5; Amgen 5; Lilly 2; Glaxo Smith Kline 2; Wyeth 2

52

POSTER SESSION I & POSTER TOURS* 11:00 am - 1:00 pm

Hall GH

*Poster Tours will begin at the ASBMR Networking Center at 11:30 AM

AGING AND MUSCLE/BONE INTERACTIONS: CELLULAR AND MOLECULAR MECHANISMS SA0001

Age-related Changes in the Activin A-myostatin-follistatin System within the Bone Marrow Microenvironment Matthew Bowser1, Norman Chutkan 2, John Martell1, Raymond Corpe1, Carlos Isales3, Mary Anne Park1, Demetric Hillman1, Mark Hamrick* 1. 1Georgia Health Sciences University, USA, 2Georgia Health Sciences Univesity, USA, 3Medical College of Georgia, USA Disclosures: Mark Hamrick, None

SA0002

Deletion of the Redox Amplifier p66shc Decreases ROS Production in Murine Bone and Increases Osteoblast Resistance to Oxidative Stress and Bone Mass Shoshana M. Bartell*, Li Han, Srividhya Iyer, Aaron Warren, Robert W. Bradsher, Randal S. Shelton, Maria Jose S. Almeida, Stavros C. Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Shoshana M. Bartell, None

SA0003

Disclosures: Franck OURY, None SA0004

Nicotinamide Phosphoribosyltransferase (Nampt) Affects the Lineage Fate Determination of Mesenchymal Stem Cells: A Possible Cause for Reduced Osteogenesis and Increased Adipogenesis In Senile Osteoporosis Yan Li*1, Xu He2, Urban Lindgren1. 1Karolinska Institute, Sweden, 2a Karolinska Institute; b Jilin University, Sweden Disclosures: Yan Li, None

SA0005

2011 ASBMR YOUNG INVESTIGATOR AWARD The ß-catenin Activating Factor, Wnt3a, stimulates Skeletal Muscle Myogenesis Sandra Romero-Suarez*1, ChengLin Mo 2, Nuria Lara3, Katharina Jaehn3, Mark Johnson4, Lynda Bonewald3, Marco Brotto3. 1Muscle Biology Group-MUBIG, School of Nursing, University of Missouri-Kansas City, USA, 2Muscle Biology Group-MUBIG, School of Nursing & Pharmacy, University of Missouri-Kansas City, USA, 3University of Missouri - Kansas City, USA, 4University of Missouri, Kansas City Dental School, USA Disclosures: Sandra Romero-Suarez, None

AGING AND MUSCLE/BONE INTERACTIONS: FRAILTY AND SARCOPENIA SA0006

Body Composition in Patients with Type 2 Diabetes Treated with Metformin and IncretinBased Drugs Olga Sukhareva, Irina Schmushkovich*, Marina Shestakova, Tatyana Chernova. National Endocrinology Research Center, Russia Disclosures: Irina Schmushkovich, None

SA0007

Diminished Mechanical Stimuli Following Transient Muscle Paralysis Are Not Associated with Acute Trabecular Bone Loss Jitendra Prasad, Phillipe Huber, Steven Bain, Ted Gross*. University of Washington, USA Disclosures: Ted Gross, None

53

Saturday

Insulin Signaling in Bone Favors Male Fertility Franck OURY*, Tatsuya YOSHIZAWA, Mathieu Ferron, Patricia Ducy, Gerard Karsenty. Columbia University, USA

SA0008

Effect of a Single Oral Dose of 600,000 IU of Cholecalciferol on Muscle Strength in Young Women with Vitamin D Deficiency: a Prospective Intervention Study Cristiana Cipriani*1, Elisabetta Romagnoli 1, Stefania Russo2, Addolorata Scarpiello2, Claudia Castro2, Roberta Pilotto2, Federica De Lucia3, Jessica Pepe2, Laura Lenge2, Salvatore Minisola1. 1University of Rome, Italy, 2Department of Internal Medicine & Medical Specialties, University of Rome "Sapienza", Italy, 3Universita Di Roma "Sapienza, Italy Disclosures: Cristiana Cipriani, None

SA0009

Genetic Variation in DHCR7/NADSYN1 (rs12785878) Predicts Skeletal Muscle Response to Resistance Training and Vitamin D Levels in Men Sreya Talasila1, Jordan Ruby 1, F Orkunoglu-Suer 2, H Gordish-Dressman 2, K Panchapakesan2, BT Harmon2, Eric Hoffman2, Joe Devaney2, Laura Tosi* 2. 1George Washington University School of Medicine, USA, 2Children’s National Medical Center, USA Disclosures: Laura Tosi, None

SA0010

High Serum Adiponectin Is Associated with Frailty and Predicts Mortality in Elderly Men. Mr OS Sweden Dan Mellstrom*1, Helena Johansson2, Carl-Johan Behre3, Hans Jutberger2, John Kanis4, ˚ sa Tivesten3, Ulf Lerner2, Magnus Karlsson5, O ¨ sten Ljunggren6, Claes Anders Ode´n 2, A Ohlsson 7, Mattias Lorentzon8. 1Sahlgrenska University Hospital, Sweden, 2Centre for Bone & Arthritis Research (CBAR), Sahlgrenska Academy University of Gothenburg Sweden, Sweden, 3Wallenberg Laboratory for Cardiovascular Research. Institute of Medicine, University of Gothenburg, Sweden, 4University of Sheffield, Belgium, 5Clinical & Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University & Department of Orthopaedics, Malmo¨ University Hospital, Malmo¨, Sweden, Sweden, 6 Department of Medical Sciences, University of Uppsala, Uppsala, Sweden, Sweden, 7 Centre for Bone & Arthritis Research, Sweden, 8Center for Bone Research at the Sahlgrenska Academy, Sweden Disclosures: Dan Mellstrom, None

SA0011

Lean Mass and the Longitudinal Probability of Mobility Disability in the Framingham Study: A Multinomial Approach for Studies of Aging Robert McLean*1, Elizabeth Newton2, Alyssa Dufour2, Joanne Murabito3, Marian Hannan4, Douglas Kiel2. 1Hebrew SeniorLife, Harvard Medical School, USA, 2Hebrew SeniorLife, USA, 3Framingham Heart Study & Boston University, USA, 4HSL Institute for Aging Research & Harvard Medical School, USA Disclosures: Robert McLean, None

SA0012

Lumbar Vertebral Bone Density is Positively Associated with Psoas Muscle Mass among Elderly Men Lynn Marshall*1, Kathleen Holton1, Joseph Zmuda 2, Jung Yoo 1, Nels Carlson1, Yahtyng Sheu2, Eric Orwoll1. 1Oregon Health & Science University, USA, 2University of Pittsburgh Graduate School of Public Health, USA Disclosures: Lynn Marshall, None

SA0013

Trunk Muscle Fat Infiltration is Greater in Women than Men and Increases with Age Dennis Anderson*1, John D’Agostino1, Alexander Bruno2, Douglas Kiel3, Mary Bouxsein 1. 1Beth Israel Deaconess Medical Center, USA, 2Stony Brook University, USA, 3 Hebrew SeniorLife, USA Disclosures: Dennis Anderson, None

AGING AND MUSCLE/BONE INTERACTIONS: REHABILITATION AND EXERCISE SA0014

Bone Responses to Body Fat Mass Loss Induced by an Exercise and Nutritional Program in Obese Rats Maude Gerbaix*1, Lore Metz1, Fabrice Mac-Way2, Christelle Guillet3, Ste´phane Walrand3, Aure´lie Masgraud3, Laurence Vico4, Daniel Courteix1. 1Universite Clermont Ferrand Laboratoire De Biologie Des APS, France, 2Hoˆtel-Dieu de Que´bec, Canada, 3INRA Universite´ d’Auvergne, France, 4University of St-Etienne, France Disclosures: Maude Gerbaix, None

54

SA0015

HIV-Cox2-based, but not HIV-BMP4-based, In Vivo Gene Transfer Strategy Promotes Osteointegration in a Rat Model of Biceps Tenodesis Shin-Tai Chen*1, Michael Coen 2, Jon Wergedal1, Charles Rundle1, Kin-Hing William Lau1. 1Jerry L. Pettis Memorial VA Medical Center, USA, 2Loma Linda University, USA Disclosures: Shin-Tai Chen, None

SA0016

Is Vitamin D Level for Muscle Strength Improvement Higher Than That for Mobility Improvement for Japanese Pre-Frail Elderly Attending a Nursing Care Prevention Class? : Examination of Alfacalcidol Supplementation and Renal Function Junko Okuno*1, Shigeo Tamura2, Takako Fukasaku3, Noriko Yabushita3, Mi-Ji Kim4, Tomohiro Okura3, Kiyoji Tanaka3, Hisako Yanagi3. 1University of Tsukuba, Japan, 2 Urawa University, Department of General Welfare, Japan, 3University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan, 4Tokyo Metropolitan Geriatric Hospital & Institute of Gerontology, Japan Disclosures: Junko Okuno, None

SA0017

The Effect of Sciatic Neurotomy and Nerve Repair on Cancellous Bone in Rat Femurs and Tibias Glenda Evans*1, Huan Wang2, Stephen Hodgson1, M. Brett Runge2, Anthony J. Windebank 2, Robert J. Spinner2, Michael Yaszemski2. 1Mayo Clinic, USA, 2Mayo Clinic College of Medicine, USA Disclosures: Glenda Evans, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: ASSESSMENT OF PEDIATRIC BONE DISEASE SA0018

Disclosures: Marisa Censani, None SA0019

Incident Vertebral Fractures among Children with Rheumatic Disorders 12 Months PostGlucocorticoid Initiation: a National Observational Study L.M. Ward*1, C. Rodd2, B. Lang3, N. Alos4, S Atkinson5, D. Cabral6, R. Couch7, E. Cummings3, A. Huber3, P.M. Miettunen8, H. Nadel6, D. Stephure 8, R. Stein9, S. Taback10, M. Matzinger1, N. Shenouda1, B. Lentle6, F. Rauch2, K. Siminoski7, - and the Canadian STOPP Consortium 11. 1University of Ottawa, Canada, 2McGill University, Canada, 3 Dalhousie University, Canada, 4Universite´ de Montre´al, Canada, 5McMaster University, Canada, 6University of British Columbia, Canada, 7University of Alberta, Canada, 8 University of Calgary, Canada, 9University of Western Ontario, Canada, 10University of Manitoba, Canada, 11Canadian Pediatric Bone Health Working Group, Canada Disclosures: L.M. Ward, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: BONE ACQUISITION SA0020

A Childhood Fracture is a Risk Factor for Both Low BMD at Growth and Low Peak Bone Mass - a Mean 28 Years Prospective Controlled Study Magnus Karlsson1, Christian Buttazzoni* 2, Lennart Landin 3, Jan-Ake Nilsson3, Bjorn Rosengren 1, Magnus Tveit4. 1Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 2 Department of Clinical Sciences & Orthopaedics, Lund University, Sweden, 3Departement of Clinical Sciences & Orthopaedics, Lund University, Sweden, 4Clinical & Molecular Osteoporosis Research Unit, Sweden Disclosures: Christian Buttazzoni, None

SA0021

An Appropriate Animal Model for Studying Maternal Bone Changes during Pregnancy: A Model Resembling Winter Pregnancy in Youth Negar Tabatabaei*1, Celia Rodd1, Richard Kremer2, Hope Weiler1. 1McGill University, Canada, 2McGill University, Royal Victoria Hospital, Canada Disclosures: Negar Tabatabaei, None

55

Saturday

Effects of Laparoscopic Adjustable Gastric Banding and Weight Loss on Bone Turnover Markers in Morbidly Obese Adolescents Marisa Censani*1, Ilene Fennoy1, Shulamit Lerner1, Rushika Conroy1, Sharon Oberfield 1, Jeffrey Zitsman1, Donald McMahon2, Shonni Silverberg 3. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA

SA0022

Effect of Letrozole, an Aromatase Inhibitor, on Skeletal and Sexual Maturation in Rats Rana Samadfam*1, Louise Pouliot2, Keith Robinson2, Paul Vancuntsem 3, Marilynn Schneider 4, Susan Y. Smith1. 1Charles River Laboratories, Canada, 2Charles River, Canada, 3Novartis, Germany, 4Novartis Pharmaceuticals Corporation, USA Disclosures: Rana Samadfam, None

SA0023

Feeding Blueberry Diets during Early Development Is Sufficient to Prevent Senescence of Osteoblasts and Bone Loss in Adulthood Jin-Ran Chen*1, Jian Zhang2, Oxana P. Lazarenko2, Michael L. Blackburn2, Kartik Shankar 2, Thomas M. Badger2, Martin J. Ronis 2. 1University of Arkansas for Medical Science, Arkansas Children’s Nutrition Center, USA, 2UAMS/ACNC, USA Disclosures: Jin-Ran Chen, None

SA0024

High Bone Mass Radiographically Mimicking Osteopetrosis but with Rapid Skeletal Turnover and Maxillofacial Giant Cell Reparative Granuloma Michael P. Whyte*1, Katherine L. Madson2, Steven Mumm1, William H. McAlister3, Deborah V. Novack4, Deborah Wenkert2, Joanne Blair5, Nicholas J. Shaw6. 1Shriners Hospital for Children & Washington University School of Medicine, St. Louis, USA, 2 Shriners Hospital for Children in St. Louis, USA, 3Department of Pediatric Radiology at the Mallinckrodt Institute of Radiology, St Louis Childrens Hospital at the Washington University School of Medicine, St. Louis, USA, 4Washington University in St. Louis School of Medicine, USA, 5Alder Hey Children’s Hospital, United Kingdom, 6Birmingham Children’s Hospital, United Kingdom Disclosures: Michael P. Whyte, None

SA0025

Interactions of Maternal and Postnatal Diet Alter Skeletal Acquisition in Male and Female Mice: Evidence for Developmental Programming of Bone Acquisition Maureen Devlin*, Leeann Louis, Christine Conlon, Alison Cloutier, Mary Bouxsein. Beth Israel Deaconess Medical Center, USA Disclosures: Maureen Devlin, None

SA0026

Sport-Specific Association Between Exercise Loading and Density, Geometry, and Microstructure of Weight-Bearing Bone in Young Adult Men Martin Nilsson*1, Claes Ohlsson2, Dan Mellstrom3, Mattias Lorentzon4. 1Centre for Bone & Arthritis Research At the Sahlgrenska Academy, Sweden, 2Centre for Bone & Arthritis Research, Sweden, 3Sahlgrenska University Hospital, Sweden, 4Center for Bone Research at the Sahlgrenska Academy, Sweden Disclosures: Martin Nilsson, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: BONE LOSS SA0027

Limited Skeletal Deficits by Peripheral Quantitative Computed Tomography in Adolescents with Anorexia Nervosa Amy DiVasta*1, Natalie Stokes1, Catherine Gordon2. 1Children’s Hospital Boston, USA, 2 Children’s Hospital Boston & Harvard Medical School, USA Disclosures: Amy DiVasta, None

SA0028

Reduced Volumetric Trabecular Bone Mineral Density of the Lumbar Spine in Adolescents with Anorexia Nervosa Lily Wheeler*1, M. Zulf Mughal2, Jane Whittaker3, Judith Adams4, Sarah Ehtisham3. 1 University of Manchester, United Kingdom, 2The University of Manchester & Royal Manchester Children’s Hospital, Endocrinology, United Kingdom, 3Royal Manchester Children’s Hospital, United Kingdom, 4Manchester Royal Infirmary, United Kingdom Disclosures: Lily Wheeler, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: PATHOPHYSIOLOGY OF PEDIATRIC BONE DISEASE SA0029

Determinants of Improvements in Bone Mineral Density (BMD) and Structure Following Initiation of Infliximab (IFX) Therapy for Childhood Crohn Disease (CD) Meena Thayu*1, Justine Shults2, Robert Baldassano2, Babette Zemel3, Mary Leonard3. 1 The Children’s Hospital of Philadelphia, USA, 2University of Pennsylvania School of Medicine, USA, 3Children’s Hospital of Philadelphia, USA Disclosures: Meena Thayu, None

56

SA0030

High Incidence of New Vertebral Fractures in Children with Leukemia after 12 Months of Chemotherapy: Results of the Canadian Steroid-associated Osteoporosis in the Pediatric Population (STOPP) Research Program N. Alos*1, R. Grant2, J. Halton3, S. Atkinson4, D. Cabral5, R. Couch6, E. Cummings 7, M. Matzinger 3, P.M. Miettunen8, H. Nadel5, C. Rodd9, N. Shenouda3, D. Stephure 8, R. Stein10, S. Taback11, F. Rauch9, B. Lentle5, K. Siminoski6, L.M. Ward3, - and the Canadian STOPP Consortium12. 1Universite´ de Montre´al, Canada, 2University of Toronto, Canada, 3University of Ottawa, Canada, 4McMaster University, Canada, 5University of British Columbia, Canada, 6University of Alberta, Canada, 7Dalhousie University, Canada, 8 University of Calgary, Canada, 9McGill University, Canada, 10University of Western Ontario, Canada, 11University of Manitoba, Canada, 12Canadian Pediatric Bone Health Working Group, Canada Disclosures: N. Alos, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: TREATMENT OF PEDIATRIC BONE DISEASE SA0031

Denosumab Treatment of Fibrous Dysplasia of Bone Alison M. Boyce*1, Jack Yao2, Marilyn H. Kelly3, Chris Chamberlain2, William Chong4, Rachel Gafni2, Alfredo Molinolo5, Natasha Cherman6, Nisan Bhattacharyya7, Michelle Ellsworth8, Josephine Kasa-Vubu 8, Michael Collins2. 1NICHD, NIDCR, NIH, USA, 2 National Institutes of Health, USA, 3SCSU, CSDB, NIDCR, NIH, USA, 4National Institute of Health, USA, 5OCPB, NIDCR, National Institutes of Health, USA, 6CSDB, NIDCR, NIH, USA, 7NIDCR, NIH, USA, 8University of Michigan Health Center, USA Disclosures: Alison M. Boyce, None

SA0032

Disclosures: Baozhi Yuan, None

BONE BIOMECHANICS AND QUALITY: ASSESSMENT OF BONE QUALITY AND STRENGTH SA0033

A Phantom for Calibrating Accuracy of DXA-Derived Femoral Neck Geometry Thomas Beck1, Ben Khoo2, Roger Price3, Thomas Beck*1, Richard Prince3, Roger Price3. 1 Quantum Medical Metrics, LLC, USA, 2Western Australian Health Department, Australia, 3Sir Charles Gairdner Hospital, Australia Disclosures: Thomas Beck, None

SA0034

Aging-Related Changes in Plasticity and Toughness of Human Cortical Bone at Multiple Length-Scales Elizabeth Zimmermann*1, Eric Schaible2, Hrishikesh Bale2, Holly Barth1, Simon Tang3, Bjoern Busse4, Tamara Alliston3, Joel Ager2, Robert O. Ritchie1. 1University of California, Berkeley, USA, 2Lawrence Berkeley National Laboratory, USA, 3University of California, San Francisco, USA, 4University of California - Berkeley, USA Disclosures: Elizabeth Zimmermann, None

SA0035

Areal Bone Mineral Density and DXA Derived Geometrical Parameters at the Tibial Diaphysis Predict 3D Indexes of Bone Strength Assessed by HR-pQCT Albrecht Popp*1, Markus Windolf2, Kurt Lippuner1, Stefano Brianza2, Andrea Tami2, R.G. Richards2, Damiano Schiuma2. 1Osteoporosis Policlinic, University of Bern, Switzerland, 2AO Research Institute Davos, Switzerland Disclosures: Albrecht Popp, None

SA0036

Association of QCT-Based Bone Strength Indices with Hip Fracture Risk among Older Men Jan Borggrefe*1, Timm de Buhr2, Smriti Shrestha3, Carrie Nielson3, Eric Orwoll3, Lynn Marshall3, Dennis Black4, Claus-C Glueer5. 1Klinik fu¨r Diagnostische Radiologie, Unversita¨tsklinik Kiel, Germany, Germany, 2Klinik fu¨r Diagnostische Radiologie, Unversita¨tsklinikum Schleswig Holstein, Campus Kiel, Germany, 3Oregon Health & Science University, USA, 4University of California, San Francisco, USA, 5Christian Albrechts Universitaet zu Kiel, Germany Disclosures: Jan Borggrefe, None

57

Saturday

Mechanism of Hexa-D-Arginine Curative Effects on the HYP Phenotype Baozhi Yuan*1, Stephen Bowman2, Robert Blank2, Iris Lindberg3, Marc Drezner2. 1 University of Wisconsin, Madison, USA, 2University of Wisconsin, USA, 3University of Maryland, USA

SA0037

Baseline Characteristics of Veterans Screened for VIVA-VA Study Violet Lagari*1, Orlando Gomez-Marin2, Silvina Levis2. 1University of Miami, USA, 2 University of Miami School of Medicine, USA Disclosures: Violet Lagari, None

SA0038

Bone Tissue Material Properties as Assessed by Reference Probe Indentation Are Associated with Proximal Femur Strength Independent of BMD Sean Serell, Mary Bouxsein, Benjamin Roberts*. Beth Israel Deaconess Medical Center, USA Disclosures: Benjamin Roberts, None

SA0039

Changes in Tibial Density and Geometry in Infantry Trainees Following Initial Military Training Rachel Izard*1, Julie Greeves2, Charles Negus3, Craig Sale4, William Fraser5. 1HQ ARTD, MOD, United Kingdom, 2HQ Army Recruiting & Training Division, United Kingdom, 3L3 Applied Technologies, USA, 4Nottingham Trent University, United Kingdom, 5Norwich Medical School, University of East Anglia, UK, United Kingdom Disclosures: Rachel Izard, None

SA0040

Effects of Multiple Exposures to Microgravity on the Femur of Adult Male Hindlimb Unloaded Rats Derrick Morgan, Joshua Davis, Yasaman Shirazi-Fard, Josh Kupke, Joseph Marchetti, Alyssa McCue, Susan Bloomfield, Harry Hogan*. Texas A&M University, USA Disclosures: Harry Hogan, None

SA0041

Evolution of Bone Strength with Age: A Large Micro-Finite Element Analysis in Women from the OFELY Cohort Nicolas Vilayphiou*1, Stephanie Boutroy1, Elisabeth Sornay-Rendu1, Bert van Rietbergen 2, Roland Chapurlat1. 1INSERM UMR1033, Universite´ de Lyon & Hospices Civils de Lyon, France, 2Department of Biomedical Engineering, Eindhoven University of Technology, Netherlands Disclosures: Nicolas Vilayphiou, None

SA0042

Finite Element Prediction of Proximal Femur Fracture Profile Based on Anisotropic Behaviour Law Coupled to Damage Awad Bettamer*1, Ridha Hambli2, Samir Allaoui2. 1L’Universite´ d’Orle´ans, France, 2 Prisme Institute, France Disclosures: Awad Bettamer, None

SA0043

High Resolution-pQCT Scanning of Radius and Tibia in Adult Patients with Osteogenesis Imperfecta Roland Kocijan*1, Christian Muschitz2, Angela Trubrich2, Christina Bittighofer2, Franz Kainberger 3, Heinrich Resch4. 1St.Vincent Hospital Vienna, Austria, 2St. Vincent’s Hospital, Austria, 3Medical University of Vienna, Austria, 4Medical University Vienna, Austria Disclosures: Roland Kocijan, None

SA0044

Increased Cortical Bone Mass Is Associated with Increased Bone Strength by Treatment with the Cathepsin K Inhibitor, ONO-5334, but not with Alendronate in Ovariectomized Monkeys Yasuo Ochi* 1, Hiroyuki Yamada2, Yasutomo Nakanishi 2, Akiko Kunishige2, Satoshi Nishikawa2, Yasuaki Hashimoto2, Hiroshi Mori2, Masafumi Sugitani2, Kazuhito Kawabata 2. 1Ono Pharmaceutical Co.,Ltd., Japan, 2Ono Pharmaceutical Co., Ltd., Japan Disclosures: Yasuo Ochi, None

58

SA0045

In-situ synchrotron SAXS Combined with Micromechanical Testing to Serve as an In-Vitro Nanomechanical Functional Imaging Technique to Measure the Bone Quality Degradation in Metabolic Bone Diseases Angelo Karunaratne* 1, Himadri Gupta1, Rrajesh Thakker2, Chris Esapa3, Jennifer Hiller4, Alan Boyde5, Nick J. Terrill4, Asa Barber6, J. H. D. Bassett7, Roger Cox8, S. Brown8, Matthew Brown9, R Head10, Peter Croucher11, Graham Williams7. 1School of Engineering & Material Sciences, Queen Mary University of London, United Kingdom, 2Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology & Metabolism, United Kingdom, 3Academic Endocrine Unit, Nuffield Department of Clinical Medicine, United Kingdom, 4I22 Non-crystalline Diffraction Diamond Light Source Harwell Science & Innovation Campus, United Kingdom, 5Queen Mary University of London, Oral Growth & Development, Institute of Dentistry, Bart’s & The London School of Medicine, United Kingdom, 6 School of Engineering & Material Sciences, Queen Mary University of London, United Kingdom, 7Molecular Endocrinology Group, MRC Clinical Sciences Centre & Division of Investigative Sciences, Imperial College London, United Kingdom, 8MRC Mammalian Genetics Unit & Mary Lyon Centre, MRC Harwell, Harwell Science & Innovation Campus, United Kingdom, 9 Diamantina Institute of Cancer, Immunology & Metabolic Medicine, Australia, 10 Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, United Kingdom, 11The Mellaby Centre for Bone Research, United Kingdom Disclosures: Angelo Karunaratne, None

SA0046

Marrow Recovery from Sub-Lethal Irradiation Is Evident Long Before Any Sign of Trabecular Bone Restoration Danielle Green*1, Benjamin Adler1, Ete Meilin Chan1, Clinton Rubin2. 1STONY BROOK UNIVERSITY, USA, 2State University of New York at Stony Brook, USA

SA0047

Microarchitecture Is Impaired In Postmenopausal Caucasian Women With Fracture Independently of Total Hip T-score - The MultiXCT Study. Stephanie Boutroy*1, Sundeep Khosla2, Elisabeth Sornay-Rendu3, Maria Belen Zanchetta 4, Donald McMahon5, Chiyuan Zhang6, Roland Chapurlat7, Jose Ruben Zanchetta 4, Emily Stein5, Cesar Bogado4, Sharmila Majumdar8, Andrew Burghardt8, Elizabeth Shane5. 1Columbia University Medical Center, New York, NY, USA, USA, 2 College of Medicine, Mayo Clinic, USA, 3INSERM, France, 4Instituto de Investigaciones Metabolicas (IDIM), Argentina, 5Columbia University College of Physicians & Surgeons, USA, 6Columbia University, USA, 7E. Herriot Hospital, France, 8University of California, San Francisco, USA Disclosures: Stephanie Boutroy, None

SA0048

Microstructural and Mechanical Differences among Postmenopausal Caucasian, African, and Hispanic American Women Bin Zhou*1, Xiaowei Liu2, Marcella Walker1, Emily Stein 2, Thomas Nickolas3, Michael Yin1, Donald McMahon2, Elizabeth Shane2, X Guo 1. 1Columbia University, USA, 2 Columbia University College of Physicians & Surgeons, USA, 3Columbia University Medical Center, USA Disclosures: Bin Zhou, None

SA0049

Non-Invasive Assessment of Bone Marrow Lipids Captures Fracture Risk Profile of Postmenopausal Women Irrespective of Diabetes History Janina Patsch*1, Thomas Baum2, Paran S. Yap2, Xiaojuan Li2, Dimitrios Karampinos 2, Sharmila Majumdar2, Ann Schwartz2, Thomas M. Link2. 1UCSF, USA, 2University of California, San Francisco, USA Disclosures: Janina Patsch, None

SA0050

Porosity, Mineralization and Morphology Interactions At The Human Tibial Cortex Naomi Hampson*1, Remi Gendron2, Guillermo Duarte2, Surya R. Kalidindi1, Karl Jepsen2, Haviva Goldman3. 1Drexel University, USA, 2Mount Sinai School of Medicine, USA, 3Drexel University College of Medicine, USA Disclosures: Naomi Hampson, None

59

Saturday

Disclosures: Danielle Green, None

SA0051

Prediction of Forearm Impact Forces during Falls on the Outstretched Hand Chantal Kawalilak*1, Joel L. Lanovaz2, James D. Johnston2, Adam D.G. Baxter-Jones 2, Saija Kontulainen2. 1College of Kinesiology, Can, 2University of Saskatchewan, Canada Disclosures: Chantal Kawalilak, None

SA0052

Pubertal Influences on Bone Strength: Results from the Fels Longitudinal Study Maja Seselj*1, Ramzi W. Nahhas1, Richard J. Sherwood 2, Wm. Cameron Chumlea1, Roger M. Siervogel 1, Stefan A. Czerwinski 1, Bradford Towne2, Dana L. Duren3. 1Lifespan Health Research Center, Department of Community Health, Wright State University, USA, 2 Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Pediatrics, Wright State University, USA, 3Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Orthopaedic Surgery, Wright State University, USA Disclosures: Maja Seselj, None

SA0053

Quantifying Bound and Pore Water in Cortical Bone with MRI Adam Horch*1, Dan Gochberg1, Jeffry Nyman2, Mark Does1. 1Vanderbilt University, USA, 2Vanderbilt University Medical Center, USA Disclosures: Adam Horch, None

SA0054

Quantitative Computed Tomography-Based Nonlinear Finite Element Method is a More Sensitive Tool for the Assessment of Therapeutic Effects of Alendronate in Elderly Osteoporoticsis Women Masako Kaneko*1, Isao Ohnishi2, Masahiko Bessho2, Takuya Matsumoto3, Satoru Ohashi3, Kenji Tobita3, Kozo Nakamura4. 1University of Tokyo, Japan, 2Center for Clinical Medical Science International University of Health & Welfare, Japan, 3Department of Orthopaedic Surgery, University of Tokyo, Japan, 4The University of Tokyo, Japan Disclosures: Masako Kaneko, None

SA0055

Relationships between Failure Patterns and Trabecular Architecture in the Thoracic Spine Amira Hussein*, Elise Morgan. Boston University, USA Disclosures: Amira Hussein, None

SA0056

Strontium Ranelate Fully Prevents Alteration of Bone Mechanical Properties in Response to Cyclical Loading Patrick Ammann* 1, Rene Rizzoli 2. 1Division of Bone Diseases, Switzerland, 2University Hospital, Switzerland Disclosures: Patrick Ammann, servier, 2

SA0057

Synchrotron Radiation Micro-CT of Intra-Element Variation in Osteocyte Lacunar Volume and Density of the Human Femur Yasmin Carter*1, David Thomas2, John G. Clement3, Andrew G. Peele4, Kevin Hannah4, David Cooper1. 1University of Saskatchewan, Canada, 2Melbourne Dental School, Australia, 3University of Melbourne, Australia, 4LaTrobe University, Australia Disclosures: Yasmin Carter, None

SA0058

The Effect of Denosumab on the Bone Matrix Mineralization in Mice Barbara Misof1, Paul Roschger*1, Michael Ominsky2, Phaedra Messmer 1, Paul Kostenuik 3, Klaus Klaushofer 1. 1Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria, 2Amgen, Incorporated, USA, 3Amgen, Inc., USA Disclosures: Paul Roschger, None

SA0059

The Loss of ATF4 Reduces the Toughness of Bone Jeffry Nyman*1, Alexander Makowski2, Sandra Wadeer2, Matthew Murry2, Xiangli Yang2. 1Vanderbilt University Medical Center, USA, 2Vanderbilt University, USA Disclosures: Jeffry Nyman, VA, 2

SA0060

Type 1 Diabetes Mellitus Effects on Bone: Preliminary Results of Peripheral Quantitative Computed Tomography (pQCT) Analysis Robert Recker1, Diane Cullen2, Laura Armas*2. 1Creighton University Osteoporosis Research Center, USA, 2Creighton University, USA Disclosures: Laura Armas, None

60

SA0061

Women with Type 2 Diabetes Have Increased Femoral Neck BMD but Not Increased Femoral Strength Dana Carpenter*1, Joyce Keyak2, Janina Patsch2, Paran Yap2, Thomas Baum2, Ann Schwartz 1, Thomas Lang2, Thomas Link2. 1University of California, San Francisco, USA, 2 University of California, USA Disclosures: Dana Carpenter, None

BONE BIOMECHANICS AND QUALITY: CHANGES IN BONE QUALITY IN UNTREATED AND TREATED OSTEOPOROSIS SA0062

Bone Tissue Micromechanical Properties are Altered Independently of Mineralization in Postmenopausal Osteoporotic Women Long-Term Treated with Alendronate Yohann Bala*1, Baptiste Depalle1, Thierry Douillard2, Sylvain Meille 2, Je´rome Chevalier2, Roland Chapurlat3, Georges Boivin1. 1INSERM, UMR 1033 ; Universite de Lyon, France, 2 INSA Lyon, MATEIS, CNRS 5510, France, 3E. Herriot Hospital, France Disclosures: Yohann Bala, None

SA0063

Development and Validation of a Mouse Model of Adynamic Bone Disease (ABD) Adeline Ng*1, Benjamin Alman2, Marc Grynpas3. 1University of Toronto Samuel Lunenfeld Research Institute, Canada, 2SICK CHILDREN’S HOSPITAL, Canada, 3 Samuel Lunenfeld Research Institute, Canada Disclosures: Adeline Ng, None

SA0064

Material Characterization of Bone Matrix in Rats: Effect of Treatment and Treatment Withdrawal Daniel Nicolella*1, Ryan Potter 1, Don Moravits1, Wei Yao2, Nancy Lane2. 1Southwest Research Institute, USA, 2University of California, Davis Medical Center, USA Disclosures: Daniel Nicolella, None

Risedronate Improves Bone Architecture in Goto-Kakizaki Rats, a Spontaneous Non-obese Model of type 2 Diabetes Tetsuo Yano*1, Mei Yamada1, Tomoyuki Konda2, Makoto Shiozaki1, Daisuke Inoue3. 1 Ajinomoto Pharmaceuticals Co., LTD, Japan, 2Ajinomoto Pharmaceuticals Co., LTD., Japan, 3Teikyo University Chiba Medical Center, Japan Disclosures: Tetsuo Yano, Ajinomoto Pharmaceuticals, 3

BONE BIOMECHANICS AND QUALITY: DISUSE OSTEOPOROSIS SA0066

Incidence of Skeletal Fractures After Spinal Cord Injury Laia Gifre*1, Pilar Peris2, Joan Vidal3, Jesu´s Benito3, Enric Portell3, Margarida Valle`s 3, Ana Monegal1, Nu´ria Guan˜abens1. 1Hospital Clı´nic of Barcelona, Spain, 2Hospital Clinic of Barcelona, Spain, 3Spinal Cord Unit. Guttmann Institute, Spain Disclosures: Laia Gifre, None

SA0067

QTL that Define Trabecular Bone’s Micro-mechanical Adaptations to Altered Mechanical Demand Engin Ozcivici*1, Weidong Zhang2, Leah Rae Donahue3, Stefan Judex4. 1Izmir Institute of Technology, Turkey, 2Jackson Laboratories, USA, 3Jackson Laboratory, USA, 4Stony Brook University, USA Disclosures: Engin Ozcivici, None

SA0068

The Role of Oxidative Stress and Antioxidant Enzymes In Bone Under Mechanical Unloading Daichi Morikawa*1, Yoshitomo Saita2, Hidetoshi Nojiri2, Keiji Kobayashi1, Kenji Watanabe 1, Yoshinori Asou3, Kazuo Kaneko2, Takahiko Shimizu1. 1Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan, 2Department of Orthopaedics, Juntendo Univ., Japan, 3Tokyo Medical & Dental University, Japan Disclosures: Daichi Morikawa, None

61

Saturday

SA0065

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING CELLULAR AND MOLECULAR EFFECTS SA0069

A Physiome Map of Mechanical and Pharmaceutical Treatment in a Mouse Model of Postmenopausal Osteoporosis Gisela Kuhn*1, Claudia Weigt2, Floor Lambers2, Ralph Mu¨ller 3. 1ETH Zu¨rich, Switzerland, 2Institute for Biomechanics, ETH Zurich, Switzerland, 3ETH Zurich, Switzerland Disclosures: Gisela Kuhn, None

SA0070

Does Loading Direction Influence the Cell’s Response to High Frequency, Low Magnitude Vibration? Sarah Manske*, Gunes Uzer, Stefan Judex. Stony Brook University, USA Disclosures: Sarah Manske, None

SA0071

Inhibition of Angiogenesis during Loading Induced Osteogenesis using avb3-targeted Nanoparticle Delivery of Fumagillin Ryan Tomlinson* 1, Anne Schmieder 1, Gregory Lanza1, Matthew Silva2. 1WASHINGTON UNIVERSITY IN ST. LOUIS, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Ryan Tomlinson, None

SA0072

Mechanical Induction of Focal Adhesion Assembly in MSC Amplifies Anti-adipogenic Signaling Pathways Buer Sen*1, Christophe Guilluy2, Zhihui Xie 2, Natasha Case3, Maya Styner3, Jacob Thomas2, Ipek Oguz2, Clinton Rubin4, Keith Burridge2, Janet Rubin3. 1University of North Carolina At Chapel Hill, USA, 2UNC, USA, 3University of North Carolina, Chapel Hill, School of Medicine, USA, 4State University of New York at Stony Brook, USA Disclosures: Buer Sen, None

SA0073

Mechanical Loading Activates Integrin a5b1 Leading to the Opening of Connexin 43 Hemichannels in Osteocytes - a Mechanism for Extracellular Release of Small Bone Anabolic Factors Nidhi Batra1, Sirisha Burra 2, Sumin Gu2, Xuechun Xia 3, Lynda Bonewald4, Eugene Sprague2, Martin Schwartz5, Jean Jiang*6. 1University of Texas Health Science Center at San Antonio (UTHSCSA), USA, 2University of Texas Health Science Center, USA, 3 University of Florida, USA, 4University of Missouri - Kansas City, USA, 5University of Virginia, USA, 6University of Texas Health Science Center at San Antonio, USA Disclosures: Jean Jiang, None

SA0074

Runx2 S301,S319 phosphorylation Controls Mechanical Force-Induced Osteoblast Gene Expression In Vitro and In Vivo. Yan Li*1, Chunxi Ge2, Jason Long1, Jose Rodriguez2, Dana Begun 1, Steven Goldstein3, Renny Franceschi4. 1University of Michigan, USA, 2University of Michigan School of Dentistry, USA, 3University of Michigan Orthopedic Research Labs, USA, 4Dept of Periodontics & Oral Medicine, University of Michigan School of Dentistry, USA Disclosures: Yan Li, None

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING EFFECTS IN HUMANS AND INTACT ANIMALS SA0075

Adenylyl Cyclase 6 Mediates In Vivo Mechanotransduction In Bone Kristen Lee*1, Dr. David A. Hoey1, Dr. Tong Tang2, Dr. H. Kirk Hammond 2, Christopher Jacobs1. 1Columbia University, USA, 2University of California San Diego, USA Disclosures: Kristen Lee, None

SA0076

Diet and Exercise Affect Postcranial - but Not Cranial - Robusticity in Mice Lynn Copes*1, Margaret R. Brown1, Elizabeth M. Dlugosz2, Stefan Judex3, Svetlana Lublinsky3, Aleksandra Oldak1, Heidi Schutz4, Steven Tommasini3, Katie Whitmore1, Theodore Garland2. 1Arizona State University, USA, 2University of California, USA, 3 Stony Brook University, USA, 4California Polytechnic University, USA Disclosures: Lynn Copes, None

62

SA0077

Effects of A 16-Week Obesogenic Diet Program on Bone Densitometry, Microarchitecture and Metabolism in Male Rat Maude Gerbaix1, Aurelie Masgrau2, Fabrice Mac Way3, Christelle Guillet2, Stephane Walrand2, Marie Therese Linossier3, Laurence Vico4, Daniel Courteix* 5, Lore METZ1. 1 Laboratoire de Biologie des APS, EA 3533, PRES Clermont Universite´, Universite´ Blaise Pascal, 24 avenue des Landais, France, 2Unite´ de Nutrition Humaine, UMR 1019, INRA/ Universite´ d’Auvergne, France, 3Laboratoire de Biologie du Tissu Osseux, Inserm U890/ IFR143, universite´ de Lyon, France, 4University of St-Etienne, France, 5Universite Clermont Ferrand Laboratoire De Biologie Des APS, France Disclosures: Daniel Courteix, None

SA0078

Inhibition of the SDF-1/CXCR4 Signaling Axis Attenuates Load-Induced Bone Formation Sara Temiyasathit 1, Philipp Leucht2, Vasavi Ramachandran1, Christopher Jacobs3, Jill Helms2, Alesha Castillo*4. 1Veterans Affairs Palo Alto Medical Center, USA, 2Stanford University, USA, 3Columbia University, USA, 4Palo Alto Veterans Affairs Medical Center, USA Disclosures: Alesha Castillo, None

SA0079

Role of CKIP-1 in Normal Fracture Healing Yixin He*1, Baosheng Guo 2, Zhong Liu3, Dahu Li 4, Fuchu He4, Lingqiang Zhang4, Ling Qin5, Ge Zhang6. 1The Cuinese University of Hong Kong, Hong Kong, 2Prince of Wales Hospital, Hong Kong, 3The Chinese University of Hong Kong, Hong Kong, 4State Key Laboratory of Proteomics, Beijing Proteomics Research Center, The Academy of Military Medical Sciences, China, 5Chinese University of Hong Kong, Hong Kong, 6Prince of Wales Hospital, Hong Kong Disclosures: Yixin He, None

SA0080

Disclosures: Karen Troy, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS TECHNIQUES SA0081

Advanced Imaging to Assess Age-Induced Mineralization Changes in Teeth Dana Begun*1, Rachel Caspari2, Rihana Bokhari3, Kristina Galdes4, Steven Goldstein5. 1 University of Michigan Orthopaedic Research Lab, USA, 2Department of Anthropology, Central Michigan University, USA, 3University of Michgan, USA, 4University of Montana, USA, 5University of Michigan Orthopedic Research Labs, USA Disclosures: Dana Begun, None

SA0082

New Method for in vitro Glycation of Proteins Grazyna Sroga*, Deepak Vashishth, Robert Davignon. Rensselaer Polytechnic Institute, USA Disclosures: Grazyna Sroga, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS: CALCIFICATION SA0083

Bone Tissue Mineral Content Is Greater in the Subtrochanteric Cortex Than in the Trochanteric or Iliac Crest Cortices Eve Donnelly*, Dennis Meredith, Joseph Nguyen, Adele Boskey. Hospital for Special Surgery, USA Disclosures: Eve Donnelly, None

SA0084

Mineral and Matrix Changes in Brtl/+ Bones and Teeth Provide Insight into Mineralization Mechanisms Adele Boskey*1, Lyudmila Spevak1, Lyudmila Lukashova1, Kostas Verdelis 1, Joan Marini2. 1Hospital for Special Surgery, USA, 2Bone & Extracellular Matrix Branch, NIH/ NICHD, USA Disclosures: Adele Boskey, None

SA0085

Raman Microscopy Detection of Cyclic Mineralization Events in Perinatal Murine Calvaria. John-David McElderry*, Guisheng Zhao, Renny Franceschi, Michael Morris. University of Michigan, USA Disclosures: John-David McElderry, None

63

Saturday

Translating the Strain Stimulus Equation from Animals to Humans William Edwards, Karen Troy*. University of Illinois at Chicago, USA

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: CARTILAGE AND CHONDROCYTES SA0086

Hdac3 Controls Growth Plate Matrix Secretion and Akt/mTOR Pathway Activation Elizabeth Bradley*, David Razidlo, Bridget Stensgard, Jennifer Westendorf. Mayo Clinic, USA Disclosures: Elizabeth Bradley, None

SA0087

Disruption of Mitogen Inducible Gene 6 (MIG6) in the Mouse Genome Accelerates Surgical Induced Osteoarthritis and Down Regulates Wnt Signaling Danese Joiner*1, Michael Morris2, Donald Scholten2, Ben Staal3, George Vande Woude3, Clifford Jones4, Debra Sietsema4, Yu-Wen Zhang3, Jim Mason5. 1Van Andel Research Institute, USA, 2Orthopaedic Cell & Tissue Mechanics Laboratory, Van Andel Research Institute, USA, 3Molecular Oncology Laboratory, Van Andel Research Institute, USA, 4 Orthopaedic Associates of Michigan, USA, 5Van Andel Institute, USA Disclosures: Danese Joiner, None

SA0088

NELL-1 Promotes Cartilage Regeneration in an In Vivo Rabbit Model Ronald Siu*1, Janette Zara2, Yaping Hou1, Jinny Kwak1, Xinli Zhang1, Aaron James1, Karina Covarrubias1, Benjamin Wu 1, Kang Ting1, Chia Soo1, Min Lee1. 1University of California, Los Angeles, USA, 2UCLA, USA Disclosures: Ronald Siu, None

SA0089

PTHrP Blocks Thyroid Hormone Signaling Through PP2A/HDAC4/Mef2 Pathway in Growth Plate Chondrocytes Lai Wang*, Yvonne Shao, R. Tracy Ballock. Cleveland Clinic, USA Disclosures: Lai Wang, None

SA0090

Roles of the Heterotypic CCN2/CTGF-CCN3/NOV and Homotypic CCN2-CCN2 Interactions in Matrix Synthesis in Chondrocytes Mitsuhiro Hoshijima*1, Takako Hattori2, Eriko Aoyama3, Takashi Nishida1, Takashi Yamashiro4, Masaharu Takigawa 5. 1Okayama University, Japan, 2Department of Biochemistry & Molecular Dentistry Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 3Biodental Research Center, Okayama University Dental School, Japan, 4Department of Orthodontics & Dentofacial Orthopedics Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 5Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sci., Japan Disclosures: Mitsuhiro Hoshijima, None

SA0091

Shh Secreted By Nucleus Pulposus Cells Is Required for the Maintenance of Postnatal Mouse Disc Chitra Dahia*, Eric Mahoney, Christopher Wylie. Cincinnati Children’s Hospital Medical Center, USA Disclosures: Chitra Dahia, None

SA0092

TGFb and Substrate Stiffness Interact to Direct Chondrocyte Differentiation Jessica Orr*1, Tamara Alliston2. 1University of California - San Francisco, USA, 2 University of California, San Francisco, USA Disclosures: Jessica Orr, None

SA0093

Time and Indentation Dependent Mechanical Response of Chondrocytes to Cyclic Loading Cynthia Thomas1, Nadeen Chahine2, Craig Blanchette*3, Gabriela Loots 4, Todd Sulchek5. 1 LLNL, USA, 2Feinstein Institute for Medical Research, USA, 3Lawrence Livermore National Laboratories, USA, 4LLNL/UC Merced, USA, 5Georgia Tech Research Institute, USA Disclosures: Craig Blanchette, None

SA0094

Vinculin-mediated Signaling from Extracellular Matrix Interacts with the Signaling Triggered by Humoral Factors and Regulates Chondrocyte Differentiation in a Sox9-independent Manner. Takao Koshimizu* 1, Masanobu Kawai1, Kanako Tachikawa 1, Keiichi Ozono2, Toshimi Michigami1. 1Osaka Medical Center & Research Institute for Maternal & Child Health, Japan, 2Osaka University Graduate School of Medicine, Japan Disclosures: Takao Koshimizu, None

64

SA0095

Wnt5a Signaling Gradient Controls Directional Cartilage Growth by Establishing Planar Cell Polarity in Chondrocytes Bo Gao*1, Hai Song1, Kevin Bishop1, Gene Elliot1, Lisa Garrett1, Milton English1, Philipp Andre1, James Robinson 1, Raman Sood1, Yasuhiro Minami2, Aris Economides3, Yingzi Yang4. 1National Human Genome Research Institute, USA, 2Kobe University, Japan, 3 Regeneron Pharmaceuticals, Inc., USA, 4NIH, USA Disclosures: Bo Gao, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENE IDENTIFICATION AND EXPRESSION SA0096

Disruption of Aldehyde Dehydrogenase 2 Gene Resulted in Altered Cortical Bone Structure and Increased Cortical BMD without Affecting Bone Length and Trabecular BMD in Femurs of Mice Takuto Tsuchiya*1, Akinori Sakai1, Toshiharu Mori 2, Kunitaka Menuki1, Yoshinori Takeuchi1, Shinkichi Kanoh1, Hajime Utsunomiya1, Teppei Murai1, Toyohi Isse1, Tsunehiro Oyama1, Toshihiro Kawamoto1, Toshitaka Nakamura 1. 1University of Occupational & Environmental Health, Japan, 2University of Occupational & Environmental Health, Jpn Disclosures: Takuto Tsuchiya, None

SA0097

Frzb is Dominant Regulator of Wnt Signaling During Early Fracture Healing in Mice Travis Burgers*1, Martin Hoffmann2, Debra Sietsema3, Bart Williams4, Clifford Jones3, Jim Mason1. 1Van Andel Institute, USA, 2Grand Rapids Medical Education Partners, USA, 3Orthopaedic Associates of Michigan, USA, 4Van Andel Research Institute, USA Disclosures: Travis Burgers, None

SA0098

Disclosures: Yukio Nakamura, None SA0099

Immunohistochemical and Histological Study on Periodontal Tissue in GK Rat Fumihiko Suwa1, Akimichi Takemura1, Naoko Yoshikawa* 2, Masatoshi Ueda3. 1Osaka Dental University, Department of Anatomy, Japan, 2Osaka Dental University, Department of Periodontology, Japan, 3Osaka Dental University, Japan Disclosures: Naoko Yoshikawa, None

SA0100

Long-Chain Saturated Fatty Acids Promote the Differentiation of Cells of the Marrow Stromal Line Kusa4b10 into Adipocytes Dorit Naot*1, Jessica Costa 2, David S Musson1, Jian-Ming Lin1, Jillian Cornish1, Andrew Grey1. 1University of Auckland, New Zealand, 2University of Auckland, Nzl Disclosures: Dorit Naot, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENERAL SA0101

Bioinspired Silicon Carbide Ceramics as Bone Substitute in an Experimental Bone Defect Rabbit Model David Guede*1, I Pereiro2, E Solla2, J Serra3, M Lo´pez-Pena4, F Mun˜oz4, Antonio Gonza´lez-Cantalapiedra4, Jose Caeiro5, Pı´o Gonza´lez2. 1Trabeculae, S.L., Spain, 2Dept. Fı´sica Aplicada, Universidad de Vigo, Spain, 32Departamento de Fı´sica Aplicada, Universidade de Vigo, Spain, 4Departamento de Ciencias Clı´nicas Veterinarias, Universidade de Santiago de Compostela, Spain, 5Orthopaedic Surgeon, Spain Disclosures: David Guede, None

65

Saturday

Histone Deacetylase-4 Plays a Role in Palatogenesis Through the Regulation of Neural Crest Cell Migration in Zebrafish Yukio Nakamura* 1, April Delaurier2, Shigeyuki Wakitani3, Hiroyuki Kato4, Charles Kimmel2. 1Shinshu University School of Medicine, Japan, 2Institute of Neuroscience, University of Oregon, USA, 3Department of Health & Sports Sciences, Mukogawa Women’s University, Japan, 4Department of Orthopaedic Surgery, Shinshu University School of Medicine, Japan

SA0102

Conditional Profilin1 Deficiency in Multiple Cell Linages of Mesenchyme Origin Based on Prx1-Cre System Severely Disrupts Axial and Appendicular Skeletal Development Daisuke Miyajima*1, Tadayoshi Hayata2, Takafumi Suzuki1, Yoichi Ezura3, Tetsuya Nakamoto 1, Takuya Notomi4, Teruo Amagasa5, Ralph T Bo¨ttcher6, Reinhard Fa¨ssler 6, Masaki Noda1. 1Tokyo Medical & Dental University, Japan, 2Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Medical Research Insititute, Japan, 4GCOE, Tokyo Medical & Dental University, Japan, 5 Department of Maxillofacial Surgery, Tokyo Medical Dental University, Japan, 6 Department of Molecular Medicine, Max Planck Institute of Biochemistry, Germany Disclosures: Daisuke Miyajima, None

SA0103

Effects of Different Treatment Regimes on Collagen-Induced Arthritic Response in the Female Lewis Rat Caroline Ruh* 1, Richard Gregson1, Aurore Varela2, Susan Y. Smith2, Richard Watson3. 1 Charles River, Canada, 2Charles River Laboratories, Canada, 3Revalesio Corporation, USA Disclosures: Caroline Ruh, None

SA0104

Human Perivascular Stem Cells and Nell-1 in Ectopic Bone Formation Janette Zara* 1, Xinli Zhang2, Aaron James2, Mirko Corselli2, Michael Chiang 2, Jonguk Chung2, Kang Ting2, Bruno Peault2, Chia Soo2. 1UCLA, USA, 2University of California, Los Angeles, USA Disclosures: Janette Zara, None

SA0105

In Vitro Testing of Biomaterial Scaffolds For Musculoskeletal Regenerative Medicine Brya Matthews*, Vieri Terreni, Sandy Lin, Karen Callon, David Musson, Ji-zhong Bai, Dorit Naot, Jillian Cornish. University of Auckland, New Zealand Disclosures: Brya Matthews, None

SA0106

Klf4 Regulates Osteoblast Differentiation Ikumi Michikami*, Makoto Abe. Osaka University Graduate School of Dentistry, Japan Disclosures: Ikumi Michikami, None

SA0107

Lymph Vessel-forming Factors and Receptors in Tooth Development in Mice Shinya Takahashi*1, Yuriko Moro2, Hiroki Watanabe2, Kimiharu Ambe2, Toshihiro Nakagawa 2. 1Ohu University, Graduate School of Dentistry, Japan, 2Ohu University, School of Dentistry, Japan Disclosures: Shinya Takahashi, None

SA0108

Modulation of Trabecular Bone Formation by Dioxin Exposure and Aryl Hydrocarbon Receptor Ablation Mikko Finnila¨*1, Maria Herlin 2, Antti Aula3, Hanna Miettinen4, Merja Korkalainen4, Juha Tuukkanen1, Timo Jamsa1, Helen Ha˚kansson2, Matti Viluksela5. 1University of Oulu, Finland, 2Karolinska Institutet, Sweden, 3University of Eastern Finland, Finland, 4 National Institute for Health & Welfare, Finland, 5National Public Health Institute, Finland Disclosures: Mikko Finnila¨, None

SA0109

Proteoglycan-4: A Dynamic Regulator of Skeletogenesis and PTH Skeletal Anabolism Chad Novince*1, Megan Michalski2, Benjamin Sinder2, Payam Entezami2, Amy Koh 2, Matthew Eber2, Thomas Rosol 3, Thomas Wronski4, Kenneth Kozloff5, Laurie McCauley1. 1 University of Michigan, School of Dentistry, USA, 2University of Michigan, USA, 3The Ohio State University, USA, 4University of Florida, USA, 5University of Michigan Department of Orthopaedic Surgery, USA Disclosures: Chad Novince, None

SA0110

Tgf-b and Erg in Intervertebral Disc Development Megan Cox*1, Rosa Serra2. 1UAB, USA, 2University of Alabama at Birmingham, USA Disclosures: Megan Cox, None

66

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: MATRIX PROTEINS SA0111

Characterization of Collagen-GFP Transgenic Mice and Evidence for Osteocyte Deposition of Perilacunar Collagen Patricia Veno 1, Suzan Kamel1, Yongbo Lu2, Yixia Xie3, Karl Kadler4, Yinhui Lu5, Charlotte Phillips6, Vladimir Dusevich3, Sarah Dallas*3. 1University of Missouri, Kansas City, USA, 2Baylor College of Dentistry/Texas A&M Health Science Center, USA, 3 University of Missouri - Kansas City, USA, 4Wellcome Trust Center for Cell Matrix Research/University of Manchester, United Kingdom, 5Wellcome Trust Center for CellMatrix Research/University of Manchester, United Kingdom, 6University of MissouriColumbia, USA Disclosures: Sarah Dallas, None

SA0112

In Vivo Analysis of Epithelial Dental and Bone Cell Cross-talks in Transgenic Mice: Experimental Models to Delineate Jaw Bone Specificity. Ariane Berdal*1, beatriz castadena2, muriel de la dure molla3, chris mueller4, frederic lezot5. 1 University Paris-Diderot, France, 2INSERM UMRS 872 University Antoquia, France, 3 INSERM UMRS 872 University Paris-Diderot, France, 4CNRS, UPR 9021 University Strasbourg, France, 5INSERM UMRS 957 University Nantes, France Disclosures: Ariane Berdal, None

SA0113

Molecular Characterization of MMP7-BMP2 Complex and the Implications for Fracture Nonunion Abdulhafez Selim*1, Hsiu Ying Sherry Wang2, Ashraf Moharam3, Marina D’Angelo4. 1 Center for Chronic Disorders of Aging, PCOM, USA, 2Inspire Pharma, Egypt, 3 Orthopaedic Surgery, Cairo University School of Medicine, Egypt, 4Philadelphia College of Osteopathic Medicine, USA

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: MECHANICAL STRESS SA0114

Sympathetic Control of Bone Mass Regulated By Osteopontin Masashi Nagao*1, Yoshitomo Saita2, Ryo Hanyu3, Tadayoshi Hayata4, Tetsuya Nakamoto 5, Yayoi Izu5, Takuya Notomi6, Shu Takeda7, Gerard Karsenty8, Susan Rittling9, Yoichi Ezura10, Jean-Pierre Vilardaga11, Masaki Noda5. 1Juntendo University Nerima Hospital, Japan, 2Department of Orthopaedics, Juntendo University School of Medicine, Japan, 3Medical Reseach Institute, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5Tokyo Medical & Dental University, Japan, 6GCOE, Tokyo Medical & Dental University, Japan, 7Keio University, Dept. of Nephrology, Endocrinology & Metabolism, Japan, 8Columbia University, USA, 9The Forsyth Institute, USA, 10Tokyo Medical & Dental University, Medical Research Insititute, Japan, 11 University of Pittsburgh, School of Medicine, USA Disclosures: Masashi Nagao, None

SA0115

Temporal Analysis of mechanical force-induced bone formation Using Quantitative Proteomics based on 8 plex- iTRAQ Wei-Bing Zhang*1, Wei-Jie Zhong2, Lin Wang2. 1Nanjing Medical University, Chn, 2 Nanjing Medical University, China Disclosures: Wei-Bing Zhang, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: PROTEINASES SA0116

Osteoblastic Cells Rely on MT1-MMP as a Regulator of Skeletal Homeostasis Emily Purcell*, Joanne Shi, Susan Yamada, Pamela Robey, Kenn Holmbeck. National Institute of Dental & Craniofacial Research, USA Disclosures: Emily Purcell, None

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Saturday

Disclosures: Abdulhafez Selim, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: CALCITONIN AND RELATED PEPTIDES SA0117

Salmon Calcitonin Suppressed Chondrocyte Hypertrophy and Cartilage Calcification ex vivo Pingping Chen 1, Kim Henriksen*1, Kim Vietz Andreassen1, Morten Karsdal1, AnneChristine Bay-Jensen2. 1Nordic Bioscience A/S, Denmark, 2Nordic Bioscience, Denmark Disclosures: Kim Henriksen, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: FGF23 AND OTHER PHOSPHATONINS SA0118

All-Trans-Retinoic Acid Inhibits Intestinal Phosphate Uptake and Type IIb SodiumDependent Phosphate Co-Transporter Gene Expression in Rat Hironroi Yamamoto* 1, Masashi Masuda1, Mina Kozai1, Sarasa Tanaka1, Otoki Nakahashi 1, Shoko Ikeda1, Hiroko Segawa2, Yutaka Taketani1, Ken-Ichi Miyamoto 2, Eiji Takeda1. 1Dept. Clinical Nutrition, University of Tokushima, Japan, 2Dept. Molecular Nutrition, University of Tokushima, Japan Disclosures: Hironroi Yamamoto, None

SA0119

Control of Iron Status Alters Phosphate Metabolism in a Mouse Model of Autosomal Dominant Hypophosphatemic Rickets (ADHR). Emily Farrow*1, Lelia Summers1, Munro Peacock2, Kenneth White1. 1Indiana University School of Medicine, USA, 2Indiana University Medical Center, USA Disclosures: Emily Farrow, None

SA0120

2011 ASBMR YOUNG INVESTIGATOR AWARD Fgf23 Regulates Calcium and Sodium Reabsorption in Renal Distal Tubules through SGK1 Signaling Olena Andrukhova*1, Carmen Streicher2, Ute Zeitz2, Beate Lanske3, Reinhold Erben2. 1 Inst. of Physiology, Pathophysiology & Biophysics, Austria, 2University of Veterinary Medicine, Austria, 3Harvard School of Dental Medicine, USA Disclosures: Olena Andrukhova, None

SA0121

MEPE-derived Phosphorylated ASARM Is Involved in FGF23/soluble Klotho-dependent Hypomineralization Yukiko Konishi*1, Yuji Yoshiko2, Tomoko Minamizaki 1, Hirotaka Yoshioka1, Masahiro Maeda3, Atsushi Shimizu4, Jane Aubin5, Norihiko Maeda1. 1Hiroshima University Graduate School of Biomedical Sciences, Japan, 2Hiroshima University, Japan, 3ImmunoBiological Laboratories Co., Ltd, Japan, 4Raffinee International Co. Ltd., Japan, 5 University of Toronto Faculty of Medicine, Canada Disclosures: Yukiko Konishi, None

SA0122

Study of the Phosphaturic Tumors that Cause Tumor-induced Osteomalacia Suggest that they Derive from Inducible Osteoprogenitor Cells William Chong*1, Rachel Gafni2, Alfredo Molinolo 3, Nisan Bhattacharyya4, Michael Collins2. 1National Institute of Health, USA, 2National Institutes of Health, USA, 3 National Institutes of Health, National Institute of Dental & Craniofacial Research, USA, 4 NIDCR, NIH, USA Disclosures: William Chong, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: PARATHYROID AND PARATHYROID HORMONE-RELATED PEPTIDE SA0123

Comparative Gene Expression in Parathyroid Oxyphil and Chief Cells Cynthia Ritter* 1, Bruce H Haughey 2, Brent Miller3, Alex Brown4. 1Washington University School of Medicine, USA, 2Department of Otolaryngology - Head & Neck Surgery, USA, 3 Renal Division, USA, 4Washington University in St. Louis School of Medicine, USA Disclosures: Cynthia Ritter, Abbott Laboratories, 2

SA0124

Mice Expressing a Phosphorylation-Deficient PTH Receptor Have Blunted Calcemic and Phosphaturic Responses to Acute PTH Challenge Akira Maeda*1, Makoto Okazaki1, Matthew Mahon1, Hiroko Segawa1, Abdul AbouSamra2, Harald Jueppner1, John Potts1, Thomas Gardella1. 1Massachusetts General Hospital, USA, 2Wayne State University, School of Medicine, USA Disclosures: Akira Maeda, Chugai, 2

68

SA0125

Pi-Transport Links the Functions of PHOSPHO1 and TNAP During the Initiation of Skeletal Mineralization Manisha Yadav*1, Carmen Huesa2, Tina Moreira3, Colin Farquharson4, Jose Luis Millan3. 1 Burnham Institute for Medical Research, USA, 2Roslin instituteUniversity of Edinburgh, United Kingdom, 3Sanford-Burnham Medical Research Institute, USA, 4Roslin Institute, University of Edinburgh, United Kingdom Disclosures: Manisha Yadav, None

SA0126

PTHrP Regulated BMP Signaling Plays A Role in the Specification of the Mammary Mesenchyme Minoti Hiremath*1, Pamela Dann2, John Wysolmerski3. 1Boise State University, USA, 2 Yale University, USA, 3Yale University School of Medicine, USA Disclosures: Minoti Hiremath, None

SA0127

Regulation of Bone Homeostasis by Transcription Factor Epiprofin Takashi Nakamura*1, Takahiro Okabe2, Takanaga Ochiai3, Eiki Koyama4, Motomi Enomoto-Iwamoto5, Satoshi Fukumoto1, Maurizio Pacifici4, Masahiro Iwamoto6, Yoshihiko Yamada7. 1Tohoku University Graduate School of Dentistry, Japan, 2Nagano Hospital, Japan, 3Matsumoto dental university, Japan, 4Children’s Hospital of Philadelphia, USA, 5The Children’s Hospital of Philadelphia Research Institute, USA, 6The Children’s Hospital of Philadelphia, USA, 7The Laboratory of Cell & Developmental Biology, NIDCR, USA Disclosures: Takashi Nakamura, None

SA0128

Disclosures: Jau-Yi Li, None SA0129

2011 ASBMR YOUNG INVESTIGATOR AWARD The Adjuvant Effects of Intermittent PTH Therapy on Massive Allograft Healing are Associated with Decreased Vasculogenesis via Differential Angiopoietin Expression and Increased Allograft Remodeling. Robinder Dhillon*1, Chao Xie 2, Laura Calvi 3, Regis O’Keefe4, Edward Schwarz4. 1 University of Rochester, Rochester, NY, USA, USA, 2Center for Musculoskeletal Research, University of Rochester, USA, 3University of Rochester School of Medicine, USA, 4University of Rochester, USA Disclosures: Robinder Dhillon, None

SA0130

The extra-long Gas variant XLas Escapes Activation-Induced Subcellular Redistribution, Thus Leading to Sustained Production of Camp and Severe Impairment of Bone Differentiation. Zun Liu1, Serap Turan2, Vanessa Wehbi3, Jean-Pierre Vilardaga4, Murat Bastepe*1. 1 Massachusetts General Hospital, Harvard Medical School, USA, 2Massachusetts General Hospital, Harvarda Meical School, USA, 3University of Pittsburgh, USA, 4University of Pittsburgh, School of Medicine, USA Disclosures: Murat Bastepe, None

SA0131

The Transcriptional Co-Activator CITED1 is Required for Normal Bone Volume and for the Full Anabolic Response to PTH In Vivo Hila Bahar*1, Jun Guo2, Hiroaki Saito3, Rajaram Manoharan 4, Dehong Yang2, Toshi Shioda2, Mary Bouxsein4, Roland Baron5, F. Richard Bringhurst2. 1MGH & HMS, USA, 2 Massachusetts General Hospital, USA, 3Harvard School of Dental Medicine, USA, 4Beth Israel Deaconess Medical Center, USA, 5Harvard School of Medicine & of Dental Medicine, USA Disclosures: Hila Bahar, None

69

Saturday

Silencing of PTH Receptor 1 in T Cells Blunts the Bone Anabolic Activity of Intermittent PTH Treatment Brahmchetna Bedi 1, Jau-Yi Li*1, Jonathan Adams1, Ming-Kang Chang2, Tatsuya Kobayashi 3, M. Neale Weitzmann4, Michaela Kneissel2, Henry Kronenberg 3, Roberto Pacifici1. 1Emory University School of Medicine, USA, 2Novartis Institutes for Biomedical Research, Switzerland, 3Massachusetts General Hospital, USA, 4Emory University School of Medicine, Atlanta VA Medical Center, USA

CANCER AND BONE: BREAST AND PROSTATE SA0132

Chronic Stress Increases Breast Cancer Metastasis to Bone via ß2AR on Osteoblasts Florent Elefteriou1, J. Campbell*2, Julie Sterling3, Xiangli Yang1. 1Vanderbilt University, USA, 2Vanderbilt Center for Bone Biology, USA, 3Vanderbilt University Medical Center, USA Disclosures: J. Campbell, None

SA0133

Genome-Wide Reciprocal Modulation of Runx2 and Estrogen Signaling in Breast Cancer Cells: Identification of a Clinically Prognostic Cell Cycle-Related Gene Cluster Nyam-Osor Chimge* 1, Sanjeev Baniwal1, Jingqin Luo2, Simon Coetzee1, Ben Berman1, Debu Tripathy1, Ellis Matthew2, Baruch Frenkel1. 1University of Southern California, USA, 2Washington University in St. Louis, USA Disclosures: Nyam-Osor Chimge, None

SA0134

Halofuginone Reduces Bone Metastases:TGF-b dependent and Independent Effects Patricia Juarez Camacho* 1, Khalid Mohammad1, Ryan Mckenna2, Holly Davis2, Xianghong Peng1, Desiree Lane1, Maryla Niewolna1, Larry Suva3, John Chirgwin1, Theresa Guise 1. 1Indiana University, USA, 2University of Virginia, USA, 3University of Arkansas for Medical Sciences, USA Disclosures: Patricia Juarez Camacho, None

SA0135

Identification of Runx2 Responsive Genes Counter-regulated by Estrogen: SNAI2 as a Mediator of Runx2-induced Invasiveness Nyam-Osor Chimge*, Sanjeev Baniwal, Yunfan Shi, Baruch Frenkel. University of Southern California, USA Disclosures: Nyam-Osor Chimge, None

SA0136

Interleukin 6 Modulates Tumor Behavior in Bone via a RANKL Dependent Pathway Yu Zheng*1, Katja Boernert1, Anastasia Mikuscheva2, Dennis Basel 3, Robert L Sutherland 4, Frank Buttgereit2, Colin Dunstan5, Dr. Hong Zhou6, Markus Seibel6. 1Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 2 Department of Rheumatology & Clinical Immunology, Charite´ University Medicine (CCM), Germany, 3ANZAC Research Institute, the University of Sydney, Australia, 4 Cancer Research Program, Garvan Institute of Medical Research, Australia, 5University of Sydney, Australia, 6Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Yu Zheng, None

SA0137

PMEPA1, a Negative Regulator of Transforming Growth Factor-b (TGFb) Signaling Pathway, Inhibits Bone Metastases from Prostate Cancer in Mice Pierrick Fournier*1, Gregory Clines2, John Chirgwin1, Theresa Guise1. 1Indiana University, USA, 2University of Alabama at Birmingham, USA Disclosures: Pierrick Fournier, None

SA0138

The Development of Bone Metastatic Lesions Is Modified By Circulating Fibronectin Anja von Au, Matthaeus Vasel, Inaam Nakchbandi*. Max-Planck Institute for Biochemistry & University of Heidelberg, Germany Disclosures: Inaam Nakchbandi, None

SA0139

The Impact of Macrophage Depletion on Bone Homeostasis and Prostate Tumor Growth Fabiana Soki*1, Sun Wook Cho1, Amy Koh2, Serk In Park2, Laurie McCauley 3. 1 University of Michigan School of dentistry, USA, 2University of Michigan, USA, 3 University of Michigan, School of Dentistry, USA Disclosures: Fabiana Soki, None

SA0140

The Mechanotransduction Pathway Regulates Tumor Response to Rigidity and PTHrP Expression Nazanin Ruppender1, Alyssa Merkel1, Scott Guelcher1, Julie Sterling* 2. 1Vanderbilt University, USA, 2Vanderbilt University Medical Center, USA Disclosures: Julie Sterling, None

70

SA0141

The Relationship Between the Presence of Parathyroid Hormone-related Protein and Molecular Subtyping in Canine Mammary Tumors: A Good Model for Human Breast Cancer. Kristi Milley*1, Chantal Denham2, Judith Nimmo3, Samantha Richardson1, Thomas John Martin4, Janine Danks1. 1School of Medical Sciences, RMIT University, Australia, 2St John of God Anatomical Pathology, Australia, 3ASAP Laboratory, Australia, 4St. Vincent’s Institute of Medical Research, Australia Disclosures: Kristi Milley, None

SA0142

Validation of In Vitro Assays For Identifying Compounds That Affect Breast And Prostate Cancer Cells Katja Fagerlund*1, Jukka Rissanen2, Jani Seppa¨nen1, Mari Suominen1, Heikki Vuorikoski 1, Jussi Halleen1. 1Pharmatest Services Ltd, Finland, 2Pharmatest Services,Limited, Finland Disclosures: Katja Fagerlund, Pharmatest Services Ltd, 3; Pharmatest Services Ltd, 4

CANCER AND BONE: GENERAL SA0143

Disclosures: Keiichiro Watanabe, None SA0144

Characterization of Bioluminescent Osteosarcoma Orthotopic Model Using Bioluminescent Imaging, Micro-computed Tomography and Histopathology Rama Garimella*, Jeff Eskew, Priyanka Bhamidi, George Vielhauer, Yan Hong, H Clarke Anderson, Ossama Tawfik, Peter Rowe. University of Kansas Medical Center, USA Disclosures: Rama Garimella, None

SA0145

Characterization of Dkk-1 Expression in an Orthotopic Murine Model of Human Osteosarcoma Tessa Grabinski, Bart Williams, Kevin Kampfschulte, Matthew Steensma*. Van Andel Research Institute, USA Disclosures: Matthew Steensma, None

SA0146

Genomic Promoter Occupancy of Runx2 Identifies Genes Involved in Cell Migration and Invasion in Osteosarcoma Cells Margaretha van der Deen1, David Lapointe1, Sneha Gupta1, Daniel Young1, Martin Montecino 2, Jane Lian1, Janet Stein1, Gary Stein1, Andre Van Wijnen*1. 1University of Massachusetts Medical School, USA, 2Universidad Andres Bello, Chile Disclosures: Andre Van Wijnen, None

SA0147

Host-derived Prostaglandin E Regulates Bone Metastases of Malignant Melanoma through Angiogenesis Morichika Takita1, Satoshi Yokoyama1, Masaki Inada*2, Chisato Miyaura1. 1Tokyo University of Agriculture & Technology, Japan, 2Toyko University of Agriculture & Technology, Japan Disclosures: Masaki Inada, None

SA0148

IAP antagonist BV6 Increases Bone Metastasis via NIK-Mediated Osteoclast Activation Chang Yang*1, Jennifer Davis2, Kathleen McCoy1, Roberta Faccio1, Deborah Novack3. 1 Washington University in St Louis School of Medicine, USA, 2Washington University in St. Louis, USA, 3Washington University in St. Louis School of Medicine, USA Disclosures: Chang Yang, None

71

Saturday

Aggravation of Myeloma Growth and Its Drug Resistance By an Acidic Milieu Created in Myeloma-Osteoclast Interaction Keiichiro Watanabe*1, Qu Cui 2, Masahiro Hiasa3, Makoto Kawatani 4, Shiro Fujii2, Takeshi Harada2, Shingen Nakamura 2, Hirokazu Miki 2, Ayako Nakano5, Kumiko Kagawa2, Kyoko Takeuchi2, Hiroyuki Osada4, Eiji Tanaka6, Toshio Matsumoto 7, Masahiro Abe8. 1The University of Tokushima Graduate School of Oral Science, Japan, 2 Department of Medicine & Bioregulatory Sciences,The University of Tokushima Graduate School, Japan, 3University of Tokushima Graduate School, Japan, 4Chemical Biology Core Facility, RIKEN Advanced Science Institute, Japan, 5University of Tokushima, Graduate School of Medicine, Japan, 6Depertmentt of Orthodontics & Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, Japan, 7University of Tokushima Graduate School of Medical Sciences, Japan, 8University of Tokushima, Japan

SA0149

Impairment of Osteoblast Differentiation and Activity in Multiple Myeloma Bone Disease: Role of Sclerostin. Silvia Colucci*1, Giacomina Brunetti2, Angela Oranger1, Giorgio Mori 3, Giorgina Specchia4, Erminia Rinaldi4, Paola Curci4, Giovanni Passeri5, Alberta Zallone6, Rita Rizzi4, Maria Grano2. 1Department of Human Anatomy & Histology, University of Bari, Italy, 2University of Bari, Italy, 3Department of Biomedical Science, University of Foggia, Italy, 4Hematology Section, Bari University, Medical School, Italy, 5Department of Internal Medicine & Biomedical Sciences, Center for Metabolic Bone Diseases, University of Parma, Italy, 6University of Bari Medical School, Italy Disclosures: Silvia Colucci, None

SA0150

Longitudinal preclinical microCT scanning: Maintaining Biological Relevance in Non-Invasive Metastatic Burden and Osteolysis Monitoring Ning Zhang1, Jay Whalen1, Anna Christensen* 2, Magdalena Bazalova3, Jeff Meganck1, Ed Lim1. 1Caliper Life Sciences, USA, 2Caliper LifeSciences, USA, 3Stanford University, USA Disclosures: Anna Christensen, Caliper Life Sciences, 3

SA0151

Novel Bis-Cyclic Thioureas, Identified from Combinatorial Libraries, Inhibit the Proliferation and PTHrP Expression of Pancreatic Cancer Cells Douglas Burton*1, Randolph Hastings2, Adel Nefzi3, Su Tu 2, Leonard Deftos4. 1VA San Diego Healthcare System / University of California, San Diego, USA, 2VA San Diego Healthcare System / University of California San Diego, USA, 3Torrey Pines Institute for Molecular Studies, USA, 4Veterans Administration San Diego Healthcare System & University of California, USA Disclosures: Douglas Burton, None

SA0152

Oncologic Doses of Zoledronic Acid Induce ONJ-Like Lesions in Rice Rats (Oryzomys palustris) with Periodontitis J. Aguirre*1, Mohammed Akhter2, Jennfer Pingel3, Xuechun Xia3, Aly Williams3, Marda Jorgensen4, Kent Edmonds5, Mercy Rivera6, Lakshmyya Kesavalu6, Thomas Wronski1. 1 University of Florida, USA, 2Creighton University Osteoporosis Research Center, USA, 3 Department of Physiological Sciences, University of Florida, USA, 4Cell & Tissue Analysis Core, McKnight Brain Institute, University of Florida, USA, 5Department of Biology, Indiana University Southeast, USA, 6Department of Periodontology & Oral Biology, College of Dentistry, Univesity of Florida, USA Disclosures: J. Aguirre, None

SA0153

Opposing Survival Effects of Amino and Carboxyl-Terminal PTHrP in Non-Small Cell Lung Carcinoma Patients Randolph Hastings* 1, Philippe Montgrain 1, Rick Quintana1, Ann Tipps2, Douglas Burton3, Leonard Deftos4. 1VA San Diego Healthcare System / University of California San Diego, USA, 2 University of California San Diego, USA, 3VA San Diego Healthcare System / University of California, San Diego, USA, 4Veterans Administration San Diego Healthcare System & University of California, USA Disclosures: Randolph Hastings, None

SA0154

Specific Receptor Tyrosine Kinases (RTKs) are Novel Therapeutic Targets for Osteosarcoma Ashley Rettew*, Mee Jee Lee, Patrick Getty, Edward Greenfield. Case Western Reserve University, USA Disclosures: Ashley Rettew, None

SA0155

The Synthetic Inhibitor of ZZ Domain of Sequestosome-1/p62 Inhibits Both Stromal Cell Independent and Dependent Myeloma Cell Growth and Osteoclast Formation Jumpei Teramachi*1, Kyaw Ze Yar Myint2, Rentian Feng2, Xiang-Qun Xie2, G. David Roodman 3, Noriyoshi Kurihara4. 1University of Pittsburgh & The Center for Bone Biology at UPMC, USA, 2University of Pittsburgh, Pharmaceutical Sciences, USA, 3University of Pittsburgh, The Center for Bone Biology at UPMC, & VA Pittsburgh Healthcare System, USA, 4University of Pittsburgh & The Center for Bone Biology, USA Disclosures: Jumpei Teramachi, None

72

SA0156

The Transcription Repressor Gfi1 Directly Interacts with the Runx2 Gene In Osteoblast Precursors To Mediate Repression by Multiple Myeloma Cells Via TNF-a, Leading To Blocked Osteoblast Differentiation Shunqian Jin*1, Sonia D’Souza 1, Quanhong Sun1, Benedicte Sammut1, H. Leighton Grimes2, G. David Roodman1, Deborah L. Galson1. 1University of Pittsburgh, Medicine/ Hematology-Oncology, The Center for Bone Biology of UPMC, & VA Pittsburgh Healthcare System, USA, 2University of Cincinnati College of Medicine/Division of Immunobiology, USA Disclosures: Shunqian Jin, None

DISORDERS OF MINERAL METABOLISM: CONGENITAL AND GENETIC BONE DISEASES SA0157

A Novel Mouse Model of Tibial Pseudarthrosis Featuring Localized Double Inactivation of the Nf1 Gene Aaron Schindeler* 1, Jad El-Hoss2, Kate Sullivan1, Tegan Cheng1, Kathy Mikulec1, Lauren Peacock1, Paul Baldock3, Ian Alexander4, David Little 1. 1The Children’s Hospital at Westmead, Australia, 2University of Sydney, Australia, 3Garvan Institute of Medical Research, Australia, 4Children’s Medical Research Institute, Australia Disclosures: Aaron Schindeler, Celgene Inc, 2

SA0158

Disclosures: Ondrej Soucek, None SA0159

Soft Tissue Postraumatic Calcifications Associated with a New FGF23 Gene Mutation: Clinicopathological and Molecular Genetic Study Maria Luisa Brandi1, Deobra Strigoli2, Caterina Fossi 2, Cristiana Casentini2, Gigliola Leoncini 2, Sergio Fabbri2, Francesco Franceschelli 2, Gemma Marcucci2, Loredana Cavalli1, Francesca Giusti2, Laura Masi*1. 1University of Florence, Italy, 2Metabolic Bone Diseases Unit, Italy Disclosures: Laura Masi, None

SA0160

Unique Contributions of Endothelial vs. Smooth Muscle Msx Gene Expression In Arteriosclerotic LDLR-Deficient Mice Jian Su Shao1, Su-Li Cheng2, Abraham Behrmann 1, Kathryn Distelhorst1, Linda Halstead1, Robert Maxson3, Dwight Towler*1. 1Washington University in St. Louis, USA, 2 Washington University in St. Louis School of Medicine, USA, 3University of Southern California, USA Disclosures: Dwight Towler, None

DISORDERS OF MINERAL METABOLISM: OSTEOMALACIA/RICKETS SA0161

Vitamin D Status in Ireland: Post IOM Interpretation Malachi McKenna*1, Barbara Murray1, Mark Kilbane2. 1St. Michael’s Hospital, Ireland, 2 St. Vincent’s University Hospital, Ireland Disclosures: Malachi McKenna, None

73

Saturday

Patients with Turner Syndrome and Isolated SHOX Deficiency Have Similar Bone Geometry At the Radius Ondrej Soucek*1, Jan Lebl 2, Jirina Zapletalova 3, Dana Novotna4, Ivana Plasilova5, Stanislava Kolouskova2, Dana Zemkova2, Miloslav Rocek6, Katerina Hirschfeldova7, Zdenek Sumnik2. 12nd Faculty of Medicine, Charles University, Prague, Czech Republic, 2 Department of Pediatrics, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Czech Republic, 3Department of Pediatrics, Palacky University, Faculty of Medicine, University Hospital Olomouc, Czech Republic, 4Department of Pediatrics, Masaryk University, Faculty of Medicine, University Hospital Brno, Czech Republic, 5 Department of Pediatrics, Charles University, Faculty of Medicine, University Hospital Hradec Kralove, Czech Republic, 6Department of Radiology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Czech Republic, 7Institute of Biology & Department of Medical Genetics, Charles University, 1st Faculty of Medicine, General University Hospital, Czech Republic

DISORDERS OF MINERAL METABOLISM: PAGET’S DISEASE SA0162

Epidemiology of Paget’s Disease of Bone in the City of Recife, Brazil Rainier Reis 1, Maı´ra Poncell1, Daniele Fontan2, Erik Diniz 2, Francisco Bandeira*3. 1 University of Pernambuco Medical School, Brazil, 2Division of Endocrinology, Agamenon Magalha˜es Hospital, Brazil, 3UPE, Brazil Disclosures: Francisco Bandeira, None

SA0163

2011 ASBMR YOUNG INVESTIGATOR AWARD Measles Virus Nucleocapsid Protein induces Autophagy in Osteoclasts: Implications for the Pathogenesis of Paget’s Disease of Bone Feng-Ming Wang*, Deborah L. Galson. University of Pittsburgh, Medicine/HematologyOncology, The Center for Bone Biology of UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Feng-Ming Wang, None

SA0164

Microarray Profile of p62P392L and Measles Virus Nucleocapsid Protein (MVNP) Regulated Gene Expression During Osteoclast Differentiation Kumaran Sundaram*1, Srinivasan Shanmugarajan1, Sudhaker Rao2, Sakamuri Reddy1. 1 Charles P. Darby Children’s Research Institute, USA, 2Henry Ford Hospital, USA Disclosures: Kumaran Sundaram, None

SA0165

TANK Binding Kinase 1 (TBK1) Mediates MVNP Effects in Pagetic Osteoclasts Quanhong Sun*1, Benedicte Sammut1, Fengming Wang1, Jolene J. Windle2, Noriyoshi Kurihara1, G. David Roodman1, Deborah L. Galson1. 1University of Pittsburgh, Medicine/ Hematology-Oncology, The Center for Bone Biology of UPMC, & VA Pittsburgh Healthcare System, USA, 2Virginia Commonwealth University, Department of Human & Molecular Genetics, USA Disclosures: Quanhong Sun, None

SA0166

2011 ASBMR YOUNG INVESTIGATOR AWARD The Expression of Measles Virus Nucleocapsid Protein (MVNP) Gene in Osteoclasts (OCLs) Induces Expression of Coupling Factors that Stimulate Bone Formation Yoko Uehata*1, Jumpei Teramachi1, Jolene Windle2, Noriyoshi Kurihara1, G. David Roodman 3. 1University of Pittsburgh & The Center for Bone Biology at UPMC, USA, 2 Virginia Commonwealth University, USA, 3University of Pittsburgh, The Center for Bone Biology at UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Yoko Uehata, None

DISORDERS OF MINERAL METABOLISM: PARATHYROID DISEASES SA0167

Bone Mineral Density (BMD) Assessment in Patients with Primary Hyperparathyroidism (PHPT) before and one year after Parathyroidectomy (PTX) Euge´nie Koumakis*1, Jean-Claude Souberbielle 2, Didier Borderie3, Emile Sarfati4, Soueda El Kettani1, Andre´ Kahan1, Catherine Cormier 5. 1Rheumatology Department A, Cochin Hospital, APHP, Paris Descartes University, France, 2Laboratoire d’exploration fonctionnelles, Hopital Necker-Enfants Malades, France, 3Laboratoire de Biochimie ge´ne´rale et spe´cialise´e, Cochin Hospital, APHP, Paris Descartes University, France, 4 Department of endocrine Surgery, APHP, Hopital Saint-Louis, France, 5AP-HP Groupe Hospitalier Cochin, France Disclosures: Euge´nie Koumakis, None

SA0168

Carotid Plaque Calcification is Increased in Mild Primary Hyperparathyroidism Marcella Walker*1, Tatjana Rundek2, James A. Lee1, Chiyuan Zhang1, Donald J. McMahon1, Ralph L. Sacco2, Shonni J. Silverberg 1. 1Columbia University, USA, 2 University of Miami, USA Disclosures: Marcella Walker, None

SA0169

Clinical and Biochemical Variables Determining BMD in Primary Hyperparathyroidism Lars Rolighed*1, Peter Vestergaard 1, Peer Christiansen2, Lene Heickendorff 3, Tanja Sikjaer1, Lars Rejnmark1, Leif Mosekilde1. 1Aarhus University Hospital, Denmark, 2 Department of Surgery P, Aarhus University Hospital, Denmark, 3Department of Biochemistry, Aarhus University Hospital, Denmark Disclosures: Lars Rolighed, None

74

SA0170

Co-morbid Medical Conditions Associated with Prevalent Hypoparathyroidism: A Populationbased Study Bart Clarke*1, Cynthia Leibson2, Jane Emerson2, Jeanine Ransom2, Hjalmar Lagast3. 1 Mayo Clinic College of Medicine, USA, 2Mayo Clinic, USA, 3NPS Pharmaceuticals, USA Disclosures: Bart Clarke, NPS Pharmaceuticals, Inc., 2

SA0171

Development of a Bioactive PTH (1-84) Specific Assay on the IDS-iSYS System Craig Dixon*1, Emma King2, Christopher Fox2, Jackie Tran3, David Laurie2, Alex Barnes2, Martha Garrity2. 1Imuunodiagnostic Systems Ltd, United Kingdom, 2IDS Ltd, United Kingdom, 3IDS Ltd, USA Disclosures: Craig Dixon, IDS Ltd, 3

SA0172

Genetic Analysis of CDKN1B/p27Kip1 Gene in Familial Primary Hyperparathyroidism Filomena Cetani*1, Elena Pardi2, Elena Paltrinieri2, Simona Borsari2, Benedetta Raspini2, Federica Saponaro2, Luisella Cianferotti1, Antonella Picone2, Chiara Banti2, Edda Vignali2, Claudio Marcocci1. 1University of Pisa, Italy, 2University of Pisa Department of Endocrinology & Metabolism, Italy Disclosures: Filomena Cetani, None

SA0173

Subclinical Hypoparathyroidism: A New Variant Based Upon a Cohort from MrOS Natalie Cusano*1, Patty Wang2, Serge Cremers3, Elizabeth Haney2, Douglas Bauer4, Eric Orwoll2, John Bilezikian1. 1Columbia University College of Physicians & Surgeons, USA, 2 Oregon Health & Science University, USA, 3Columbia University, USA, 4University of California, San Francisco, USA Disclosures: Natalie Cusano, None

SA0174

Vitamin D Status in Primary Hyperparathyroidism Alfredo Scillitani*. Casa Sollievo Della Sofferenza Scientific Institute, Italy

DISORDERS OF MINERAL METABOLISM: RENAL BONE DISEASE SA0175

Calcium Carbonate Supplement Produces Positive Calcium Balance in Stage 3/4 Chronic Kidney Disease Kathleen Hill* 1, Berdine Martin2, Meryl Wastney3, Sharon Martin Moe4, George McCabe2, Connie Weaver2, Munro Peacock5. 1Indiana University School of Medicine, USA, 2Purdue University, USA, 3Metabolic Modeling Services, USA, 4Indiana University, USA, 5Indiana University Medical Center, USA Disclosures: Kathleen Hill, None

SA0176

Cortical Abnormalities are Associated with Prevalent Fractures in Postmenopausal Women with Chronic Kidney Disease Emily Stein* 1, Thomas Nickolas2, Donald McMahon1, Adi Cohen2, Xiaowei Liu1, Mafo Kamanda-Kosseh3, X Guo3, Elizabeth Shane1. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University Medical Center, USA, 3Columbia University, USA Disclosures: Emily Stein, None

SA0177

High Turnover Renal Osteodystrophy is Associated with b-Catenin Repression in Osteocytes Yves Sabbagh*, Wen Tang, Christina Bracken, Stephen O’Brien, Lucy Phillips, Sue Ryan, Shiguang Liu, Susan Schiavi. Genzyme Corporation, USA Disclosures: Yves Sabbagh, Genzyme Corporation, 3

DISORDERS OF MINERAL METABOLISM: RHEUMATOLOGIC AND OTHER SYSTEMIC ILLNESSES SA0178

2011 ASBMR YOUNG INVESTIGATOR AWARD Adenovirus-Mediated Gene Transfer of Adiponectin Reduces Osteoclasts Differentiation and Bone Erosion of Collagen-Induced Arthritis in Mice Kosuke Ebina*1, Kazuya Oshima1, Makoto Hirao2, Jun Hashimoto 1, Kenrin Shi1, Hideki Yoshikawa1. 1Osaka University, Graduate School of Medicine, Department of Orthopedics, Japan, 2Osaka University Graduate School of Medicine, Department of Orthopaedics, Japan Disclosures: Kosuke Ebina, None

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Disclosures: Alfredo Scillitani, None

SA0179

Identification of Pathological Bone Mineralization in Diabetic Osteomyelitis Karen Esmonde-White*1, Francis Esmonde-White 2, Crystal Holmes1, Michael Morris2, Blake Roessler1. 1University of Michigan Medical School, USA, 2University of Michigan, USA Disclosures: Karen Esmonde-White, None

SA0180

ONO-5334, a Potent Cathepsin K Inhibitor, Suppresses Joint Destruction in the Monkey Collagen-induced Arthritis Model Hiroshi Mori*1, Hiroyuki Yamada2, Yasutomo Nakanishi2, Akiko Kunishige 2, Satoshi Nishikawa2, Yasuaki Hashimoto2, Yasuo Ochi2, Masafumi Sugitani2, Kazuhito Kawabata 2. 1Ono Pharmaceutical Co.,Ltd., Japan, 2Ono Pharmaceutical Co., Ltd., Japan Disclosures: Hiroshi Mori, None

SA0181

Relationship Between Periodontitis and Arthritis. Melissa Cantley*, David Haynes, Victor Marino, Peter Mark Bartold. University of Adelaide, Australia Disclosures: Melissa Cantley, None

DISORDERS OF MINERAL METABOLISM: TRANSPLANTATION SA0182

Bone Histomorphometry Findings in Pediatric Solid Organ Transplant Patients Inari Tamminen* 1, Helena Valta2, Hanna Isaksson3, Sari Salminen4, Mervi K. Mayranpaa 5, Hannu Jalanko5, Heikki Kroger6, Outi Makitie7. 1Bone & Cartilage research Unit (BCRU), University of Eastern Finland, Finland, 2Hospital for Children & Adolescents, University of Helsinki, Helsinki Finland, Finland, 3University of Eastern Finland, Finland, 4Children’s Hospital, Helsinki University Central Hospital, Finland, 5 Children’s Hospital, Helsinki University Central Hospital & University of Helsinki, Finland, 6Kuopio University Hospital, Finland, 7Hospital for Children & Adolescents, Helsinki University Hospital, Finland Disclosures: Inari Tamminen, None

DISORDERS OF MINERAL METABOLISM: VASCULAR AND ECTOPIC CALCIFICATION SA0183

Advanced Glycation End Products-Induced Vascular Calcification Is Mediated By Oxidative Stress: Functional Roles of NAD(P)H-oxidase Yuko Tada*1, Shozo Yano 2, Kyoko Okazaki1, Noriko Ogawa1, Miwa Morita1, Ippei Kanazawa3, Toru Yamaguchi 2, Toshitsugu Sugimoto4. 1Shimane Uniersity Faculty of Medicine, Japan, 2Shimane University Faculty of Medicine, Japan, 3McGill University, Canada, 4Shimane University School of Medicine, Japan Disclosures: Yuko Tada, None

SA0184

Aortic Arch Calcification Is Associated With Low Bone Mineral Density But Not Orthostatic Hypotension In Advanced Old Age Jude Ryan*1, Sheila Carew 2, Catriona O’Connell 3, Teresa Donnelly 2, Catherine Peters2, Aine Costelloe2, Tina Sheehy2, Declan Lyons2. 1Midwest Regional Hospital, Limerick, Ireland, Ireland, 2Clinical Age Assessment Unit, Department of Medicine, Division of Ageing & Therapeutics, University of Limerick Medical School & Mid-West Regional Hospital, Ireland, 3Midwest regional Hospital, Ireland Disclosures: Jude Ryan, None

SA0185

miRNA-125b is Involved in Calcification of Vascular Smooth Muscle Cells Claudia Goettsch*1, Martina Rauner2, Lorenz Hofbauer3. 1Department of Medicine III, Technical University, Dresden, USA, 2Medical Faculty of the TU Dresden, Germany, 3 Dresden Technical University Medical Center, Germany Disclosures: Claudia Goettsch, None

SA0186

PHOSPHO1: a Novel Therapeutic Target for Medial Vascular Calcification Tina Kiffer-Moreira*1, Manisha C. Yadav1, Dongxing Zhu2, Yalda Bravo3, Russell Dahl3, Sonoko Narisawa1, Boguslaw Stec1, Vicky E. MacRae2, Colin Farquharson 4, Jose´ Luis Milla´n 1. 1Sanford Children’s Health Research Center, Sanford-Burnham Medical Research Institute, USA, 2The Roslin Institute, The University of Edinburgh, United Kingdom, 3 Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, USA, 4The Roslin Institute, The University of Edinburgh, USA Disclosures: Tina Kiffer-Moreira, None

76

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: GENERAL STUDIES SA0187

A 4-bp Deletion Mutation in DLX3 Enhances Anti-adipogenic Activity of DLX3 Hye-Lim Lee*1, Kyung Hwa Baek2, Kyung Mi Woo3, Hyun-Mo Ryoo3, Gwan-Shik Kim1, Jeong-Hwa Baek1. 1Seoul National University School of Dentistry, South Korea, 2Seoul National Univeristy School of Dentistry, South Korea, 3Seoul National University, School of Dentistry, South Korea Disclosures: Hye-Lim Lee, None

SA0188

Adaptation of Bone and Calcium Metabolism to Low Dietary Calcium (Ca) Intake is Affected by Genetic Background in Mice Qiang Li*, Rebecca McCreedy, James Fleet. Purdue University, USA Disclosures: Qiang Li, None

SA0189

Differential Effect of ApoE Isoforms on Trabecular Bone Mass and Bone Turnover in Mice Marco Dieckmann1, F. Timo Beil2, R. Percy Marshall2, Alexander Bartelt2, Wolfgang Ruether2, Michael Amling 2, Joachim Herz3, Andreas Niemeier* 2. 1UT Southwestern Medical Center, USA, 2University Medical Center Hamburg-Eppendorf, Germany, 3Center for Alzheimer’s & Neurodegenerative Disease, USA Disclosures: Andreas Niemeier, None

SA0190

Etanercept for the Treatment of Inflammation in Cherubism Mice Teruhito Yoshitaka*1, Tomoyuki Mukai2, Ernst Reichenberger 3, Yasuyoshi Ueki 4. 1 University Missouri-Kansas City School of Dentistry, USA, 2University of Missouri Kansas City, USA, 3University of Connecticut Health Center, USA, 4University of Missouri-Kansas City School of Dentistry, USA Disclosures: Teruhito Yoshitaka, None

Mechanisms of Bone Loss in Cystic Fibrosis Bone Disease Katrina Clines, Joon Chung, Gregory Clines*. University of Alabama at Birmingham, USA Disclosures: Gregory Clines, None

SA0192

Osteoanabolic Treatment of Adult Osteogenesis Imperfecta with Teriparatide: Preliminary Results of an 36-month prospective observational study Parvis Farahmand*1, Johann Ringe 1, Thomas Nickelsen 2. 1West German Osteoporosis Center, Leverkusen Clinic, University of Cologne, Germany, 2Eli Lilly Deutschland GmbH, Germany Disclosures: Parvis Farahmand, None

SA0193

Over Expression of Tissue-nonspecific Alkaline Phosphatase in Osteoblasts Increases Bone Mineralization by Dephosphorylating Osteopontin Sonoko Narisawa* 1, Manisha Yadav2, Jose Luis Millan3. 1Sanford Burnham Medical Research Institute, USA, 2Burnham Institute for Medical Research, USA, 3SanfordBurnham Medical Research Institute, USA Disclosures: Sonoko Narisawa, None

SA0194

2011 ASBMR YOUNG INVESTIGATOR AWARD SH3BP2 Cherubism Mutation Enhances Lipopolysaccharide-induced Osteoclastogenesis Tomoyuki Mukai*1, Teruhito Yoshitaka2, Yasuyoshi Ueki 3. 1University of Missouri Kansas City, USA, 2University Missouri-Kansas City School of Dentistry, USA, 3 University of Missouri-Kansas City School of Dentistry, USA Disclosures: Tomoyuki Mukai, None

SA0195

Teriparatide Increases Bone Mineral Density in a Man with Osteoporosis Pseudoglioma John Bilezikian1, Marise Lazaretti Castro2, Elizabete Ribeiro Barros3, Henrique Arantes*4, Ilda Kunii3. 1Columbia University College of Physicians & Surgeons, USA, 2Federal University of Sao Paulo, Brazil, 3Sa˜o Paulo Federal University, Brazil, 4Brazil Disclosures: Henrique Arantes, None

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SA0191

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: LINKAGE STUDIES AND POLYMORPHISMS SA0196

A Genome-wide Association Meta-analysis Identifies Two Loci for Cortical Thickness Mattias Lorentzon* 1, Lavinia Paternoster 2, Terho Lehtima¨ki 3, Mika Ka¨ho¨nen4, Olli Raitakari5, Marika Laaksonen6, Vera Mikkila¨6, Jorma Viikari7, Leo-Pekka Lyytika¨inen 3, John P Kemp2, Adrian Sayers8, Maria Nethander9, Liesbeth Vandenput 10, Jon H Tobias2, Claes Ohlsson11, David M Evans2. 1Center for Bone Research at the Sahlgrenska Academy, Sweden, 2MRC CAiTE centre, School of Social & Community Medicine, University of Bristol, United Kingdom, 3Department of Clinical Chemistry, University of Tampere & Tampere University Hospital, Finland, 4Department of Clinical Physiology, University of Tampere & Tampere University Hospital, Finland, 5Research Centre of Applied & Preventive Cardiovascular Medicine, University of Turku & the Department of Clinical Physiology, Turku University Hospital, Finland, 6Department of Food & Environmental Sciences, University of Helsinki, Finland, 7Department of Medicine, University of Turku & Turku University Hospital, Finland, 8University of Bristol, United Kingdom, 9Center for Bone & Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden, 10University of Gothenburg, Sweden, 11Centre for Bone & Arthritis Research, Sweden Disclosures: Mattias Lorentzon, None

SA0197

Bone Mineral Density is Reduced in Subjects with Familial Defective Apolipoprotein B-100 Laura Yerges-Armstrong*1, Haiqing Shen1, Elizabeth Streeten 2, Alan Shuldiner1, Braxton Mitchell3. 1University of Maryland, USA, 2University of Maryland School of Medicine, USA, 3University of Maryland, Baltimore, USA Disclosures: Laura Yerges-Armstrong, None

SA0198

Functionality of Bone-Specific Promoter SNPs in Human Bones In Vivo and Influence on the Phenotypic Variability of Osteogenesis Imperfecta (OI) Aline Domingues 1, Marc delepine2, Anne Boland2, Diana Zelenika 2, Didier Hannouche3, Marie-Christine De Vernejoul4, Frederic Jehan*5. 11Inserm UMR 606 & University ParisDiderot, Hoˆpital Lariboisie`re, France, 2Centre National de Ge´notypage (CNG), CEA, France, 3Department of Orthopaedic Surgery & Traumatology, AP-HP & University ParisDiderot, France, 4Fe´de´ration De Rhumatologie Et INSERM U606, France, 5INSERM Unit 606, France Disclosures: Frederic Jehan, None

SA0199

Large-scale Meta-analysis of Genome-Wide Association Studies for Bone Mineral Density at Radius: the GEFOS Consortium Hou-Feng Zheng*1, Laura Yerges-Armstrong2, Joel Eriksson 3, Emma Duncan4, Braxton Mitchell5, Claes Ohlsson6, Elizabeth Streeten7, Mattias Lorentzon 8, Brent Richards9. 1 Department of Human genetics & Epidemiology & Biostatistics, McGill University, Canada, 2University of Maryland, USA, 3Center for Bone & Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Sweden, 4Royal Brisbane & Women’s Hospital, Australia, 5University of Maryland, Baltimore, USA, 6Centre for Bone & Arthritis Research, Sweden, 7University of Maryland School of Medicine, USA, 8Center for Bone Research at the Sahlgrenska Academy, Sweden, 9McGill University, Canada Disclosures: Hou-Feng Zheng, None

GROWTH FACTORS AND CYTOKINES: BONE MORPHOGENETIC PROTEINS SA0200

Dullard Is a Novel Common Negative Regulator of BMP Signaling in Osteoblasts and Chondrocytes Acting at Smad1 Level Independently of Caveolae-Proteasome Pathway Tadayoshi Hayata*1, Yoichi Ezura2, Makoto Asashima3, Ryuichi Nishinakamura4, Masaki Noda5. 1Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 2 Tokyo Medical & Dental University, Medical Research Insititute, Japan, 3Graduate School of Arts & Sciences, The University of Tokyo, Japan, 4Department of Kidney Development, Institute of Molecular Embryology & Genetics (IMEG), Kumamoto University, Japan, 5Tokyo Medical & Dental University, Japan Disclosures: Tadayoshi Hayata, None

78

SA0201

Inflammation Induces Expression of BMP3, an Inhibitor of Bone Formation, in Inflammatory Arthritis Melissa Matzelle*1, Anita Shaw1, Jun Li1, Sougata Karmakar 1, Catherine Manning1, Nicole Walsh2, Vicki Rosen3, Ellen Gravallese1. 1University of Massachusetts Medical School, USA, 2St Vincent’s Institute of Medical Research, Australia, 3Harvard School of Dental Medicine, USA Disclosures: Melissa Matzelle, Abbott Bioresearch Center, 99

SA0202

Transplanted Mesenchymal Stem Cell-derived BMP2 Rescues Fracture Healing in BMP2deficient Mouse Limbs Timothy Myers*1, Froilan Granero-Molto2, Lara Longobardi 2, Yun Yan1, Tieshi Li 1, Ying Li1, Anna Spagnoli2. 1University of North Carolina, USA, 2University of North Carolina at Chapel Hill, USA Disclosures: Timothy Myers, None

GROWTH FACTORS AND CYTOKINES: FIBROBLAST GROWTH FACTORS SA0203

FGF23 Affects the Lineage Fate Determination of Mesenchymal Stem Cells Xu He*1, Tobias Larsson2, Jiaxue He3, Urban Lindgren 2, Yan Li 2. 1a Karolinska Institute; b Jilin University, Sweden, 2Karolinska Institute, Sweden, 3a Karolinska Institute; b Jilin University, Sweden Disclosures: Xu He, None

SA0204

HMWFGF2 Isoforms Regulate Bone Nodule Formation via Modulating FGFR/FGF23/ERK Signaling in BMSCs Liping Xiao*1, Alycia Esliger1, Marja Marie Hurley2. 1University of Connecticut Health Center, USA, 2University of Connecticut Health Center School of Medicine, USA

GROWTH FACTORS AND CYTOKINES: GENERAL SA0205

Analysis of Wnt System Components in Cranial Defect Healing in CXC Receptor Knock-out (mCXCR-/-) Mice by Microarray David Bischoff*1, Weibiao Huang1, Erwin Kruger2, Nalini Makhijani3, Dean Yamaguchi4. 1 VA Greater Los Angeles Healthcare System & David Geffen School of Medicine at UCLA, USA, 2UCLA, USA, 3VA GLAHS, USA, 4VA Greater Los Angeles Healthcare System, USA Disclosures: David Bischoff, None

SA0206

Differential Impact of Dkk1 Neutralizing Antibodies on Wnt Signaling and Bone Mineral Density Wei Fan*1, Grisanti Mario1, Jilin Sun1, Hsieng S. Lu 1, Xiaodong Li 2, William G. Richards 1. 1Amgen Inc., USA, 2Amgen Inc, USA Disclosures: Wei Fan, Amgen, Inc, 1; Amgen, Inc, 3

SA0207

EGFL6 Promotes Endothelial Cell Migration and Angiogenesis Through the Activation of ERK Jennifer Tickner*1, Shek Man Chim1, Qin An1, Ming Hao Zheng1, Nathan Pavlos2, Jiake Xu2. 1University of Western Australia, Australia, 2The University of Western Australia, Australia Disclosures: Jennifer Tickner, None

SA0208

Increased WNT Signaling in Sclerostin/Sostdc1 Double Knockouts Causes Preaxial Polydactyly Richard Harland1, Deepa Murugesh2, Gabriela Loots3, Cristal Yee4, Nicole Collette*2. 1 University of California, Berkeley, USA, 2Lawrence Livermore National Laboratory, USA, 3LLNL/UC Merced, USA, 4University of California, Merced, USA Disclosures: Nicole Collette, None

SA0209

Intermittent Injections of Osteocalcin Improve Glucose Metabolism and Prevent Type 2 Diabetes In Mice Mathieu Ferron*1, Marc McKee2, Patricia Ducy1, Gerard Karsenty1. 1Columbia University, USA, 2McGill University, Canada Disclosures: Mathieu Ferron, None

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Disclosures: Liping Xiao, None

SA0210

Modulation of SDF-1/CXCR4 Axis Enhances rhBMP-2-induced Ectopic Bone Formation Joel Wise, D. Rick Sumner, Amarjit Virdi*. Rush University Medical Center, USA Disclosures: Amarjit Virdi, None

SA0211

New Function of Nell-1 Protein in Regulating Bone Maintenance Aaron James*1, Xinli Zhang1, Janette Zara2, Michael Chiang1, Wei Yuan 1, Raghav Goyal1, Cymbeline Culiat3, Kang Ting1, Chia Soo1. 1University of California, Los Angeles, USA, 2UCLA, USA, 3Oak Ridge Laboratories, USA Disclosures: Aaron James, None

SA0212

Regucalcin Stimulates Osteoclastogenesis and Suppresses Osteoblastogenesis by NF-kB Activation Masayoshi Yamaguchi*1, M. Neale Weitzmann2. 1Emory University School of Medicine, USA, 2Emory University School of Medicine & the Atlanta VA Medical Cemter, USA Disclosures: Masayoshi Yamaguchi, None

SA0213

Transgenic Adult Murine Mesenchymal Stem Cells Conditionally Overexpressing SDF-1b Enhance New Bone Formation in Both In Vitro and In Vivo Model Systems Samuel Herberg*, Sadanand Fulzele, Nianlan Yang, Galina Kondrikova, Khaled Hussein, Mohammed E. Elsalanty, Maribeth Johnson, Xingming Shi, Mark Hamrick, William D. Hill. Georgia Health Sciences University, USA Disclosures: Samuel Herberg, None

GROWTH FACTORS AND CYTOKINES: INSULIN-LIKE GROWTH FACTORS AND BINDING PROTEINS SA0214

Ephrin B2-EphB4 Bidirectional Signaling Mediates the Actions of IGF-I Signaling in Regulating Chondrocyte and Osteoclast Differentiation Yongmei Wang*, Hashem Elalieh, Wenhan Chang, Daniel Bikle. Endocrine Unit, University of California, San Francisco/VA Medical Center, USA Disclosures: Yongmei Wang, None

SA0215

Requirement of Shp2 in Chondrogenesis and Cartilage Homeostasis Yingnan Yu*1, Jianguo Wang2, Kai Zhao2, Douglas Moore2, Zhengke Wang3, Qian Wu4, Di Chen5, Quesenberry Peter6, Wentian Yang7. 1Brown University Alpert Medical School & Rhode Island Hospital, Providence, RI, USA, 2Departments of Orthopedics, RI Hospital & Brown University Alpert Medical School, USA, 3Roger Williams Hospital, USA, 4 Department of Pathology & Laboratory Medicine, University of Connecticut Health Center, USA, 5Center for Musculoskeletal Research, Department of Orthopaedics & Rehabilitation, University of Rochester, Rochedter, NY, USA, 6Departments of Medicine, RI Hospital & Brown University Alpert Medical School, USA, 7Brown University Alpert Medical School, USA Disclosures: Yingnan Yu, None

GROWTH FACTORS AND CYTOKINES: TRANSFORMING GROWTH FACTOR SA0216

TGFb Dependent Repression of MMP13 in Chondrocytes Via a Smad3 and Runx2 Dependent Pathway Daniel Thuillier*1, Carol Chen2, Emily Chin2, Tamara Alliston2. 1UCSF, USA, 2University of California, San Francisco, USA Disclosures: Daniel Thuillier, None

OSTEOBLASTS: APOPTOSIS AND CELL CYCLE SA0217

FoxO1 is a Bimodal Transcriptional Modulator of Bone Formation Aruna Kode*, Ioanna Mosialou, Charles Duncan, Barbara Silva, Stavroula Kousteni. Columbia University Medical Center, USA Disclosures: Aruna Kode, None

SA0218

Identification of Mechanisms of Lipoapoptosis in Normal Human Osteoblasts Krishanthi Gunaratnam*1, Christopher Vidal 1, Chris Thekkedam2, Ross Boadle3, Gustavo Duque2. 1University of Sydney, Australia, 2Ageing Bone Research Program, University of Sydney, Australia, 3Millennium Research Institute, Australia Disclosures: Krishanthi Gunaratnam, None

80

OSTEOBLASTS: BONE FORMATION AND BONE RESORPTION SA0219

Alcohol Consumption Delays Bone Healing in Association with Reduced Osteocalcin Expression after Drill Hole Injury Yoshinori Takeuchi*1, Akinori Sakai 1, Toshiharu Mori 2, Takuto Tsuchiya1, Shinkichi Kanoh1, Toshitaka Nakamura1. 1University of Occupational & Environmental Health, Japan, 2University of Occupational & Environmental Health, Jpn Disclosures: Yoshinori Takeuchi, None

SA0220

Calcium Aluminate Scaffolds Covalently Linked with Melatonin Show Osteoconductivity and Osteoinductivity William Clafshenkel1, Rachelle Palchesko2, Jared Romeo2, James Rutkowski3, Kenneth McGowan 4, Ellen Gawalt2, Paula Witt-Enderby*5. 1Duquesne University, Grad School of Pharmaceut Sci, USA, 2Duquesne University Bayer School of Natural & Environmental Sci, USA, 3Clarion Research Group, USA, 4Westmoreland Advanced Materials, LLC, USA, 5Duquesne University, School of Pharmacy, USA Disclosures: Paula Witt-Enderby, None

SA0221

Withdrawn

SA0222

Correction of the Haploinsufficient Hematopoietic Microenvironment is Sufficient to Normalize the Pathological Fracture Repair in Genetically Engineered Murine Model of Neurofibromatosis Type 1 Xiaohua Wu*1, Shi Chen1, Yongzheng He1, Steven Rhodes2, Xiaohong Li 1, Xianlin Yang1, Li Jiang 1, Grzegorz Nalepa1, Khalid Mohammad2, Alexander Robling2, D. Wade Clapp1, Simon Conway1, Theresa Guise2, Feng-Chun Yang2. 1Indiana University School of Medicine, USA, 2Indiana University, USA Disclosures: Xiaohua Wu, None

Decreased Bone Formation and Bone Resorption Following Fracture in Osteoblast-Osteocyte Specific Connexin 43 Deficient Mice Alayna Loiselle*1, Emmanuel Paul2, Gregory Lewis2, Henry Donahue3. 1Penn State Hershey, USA, 2Penn State College of Medicine, USA, 3The Pennsylvania State University College of Medicine, USA Disclosures: Alayna Loiselle, None

SA0224

Disruption of the Runx2 Response to SMAD signaling Affects Bone Turn-over in Adult Mice Yang Lou*1, Sadiq Hussain2, Dana Frederick2, Andre Van Wijnen 2, Gary Stein 2, Jane Lian2, Janet Stein2. 1University of Massachusetts, USA, 2University of Massachusetts Medical School, USA Disclosures: Yang Lou, None

SA0225

Forming Bone in Artificial Patterns Using Mother of Pearl Ronke Olabisi*, Maude Rowland, Christy Franco, Joseph Hoffmann, Jennifer West. Rice University, USA Disclosures: Ronke Olabisi, None

SA0226

Impact of Omega-3 Polyunsaturated Fatty Acids on Bone During Chronic Simulated Resistance Training Kaleigh Camp*, David Cunningham, Evelyn Yuen, Brandon Macias, Stuart Solomon, Harry Hogan, Susan Bloomfield. Texas A&M University, USA Disclosures: Kaleigh Camp, None

SA0227

Maintenance of Human Osteoblasts, Mesenchymal Stem Cells, and Bone Explants In Vitro Without the Use of Animal Derived Materials. Mrs Carole Elford, Deborah Mason, Dr Jim Ralphs, Professor John W. Gregory, Dr Alastair J. Sloan, Bronwen Evans*. Cardiff University, United Kingdom Disclosures: Bronwen Evans, None

SA0228

Mature Osteoclasts Produce S1P to Support Osteoblast Differentiation via S1P Receptor Engagement and RhoA Activation Patrick Quint*1, Moustapha Kassem2, Jennifer Westendorf3, Sundeep Khosla4, Merry Jo Oursler3. 1Mayo Clinic Rochester, USA, 2Odense University Hospital, Denmark, 3Mayo Clinic, USA, 4College of Medicine, Mayo Clinic, USA Disclosures: Patrick Quint, None

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SA0223

SA0229

Mechanosensitivity of Osteoblasts Could Be Up-regulated by Inhibition of Cytoskeleton Reorganization Qiang Fu*1, Yun Shen2, Yiping Zhang3, Changjing Wu 3, Rui Chen3. 1School & Hospital of Stomatology, Sun Yat-sen University, Peoples Republic of China, 2School & Hospital of Stomatology, Sun Yat-sen University (present address is Shanghai Tenth People’s Hospital, Shanghai), China, 3School & Hospital of Stomatology, Sun Yat-sen University, China Disclosures: Qiang Fu, None

SA0230

Osteoblastic ephrinB2 Is Required for Normal Osteoblast Differentiation and Function in vitro and in vivo. Farzin Takyar*, Stephen Tonna, Blessing Crimeen-Irwin, T. John Martin, Natalie Sims. St. Vincent’s Institute of Medical Research, Australia Disclosures: Farzin Takyar, None

SA0231

Osterix Deficiency Disrupts Ameloblast and Odontoblast Maturation but Not Tooth Morphogenesis Ji-Myung Bae* 1, Harunur Rashid1, Haiyan Chen2, David Summerford1, Mitra Adhami1, Dobrawa Napierala3, Krishna Sinha4, Soraya Gutierrez5, Benoit DeCrombrugghe4, Amjad Javed2. 1School of Dentistry, University of Alabama at Birmingham, USA, 2University of Alabama at Birmingham, USA, 3University of Alabama at Birmingham, School of Dentistry, USA, 4UT MD Anderson Cancer Center, USA, 5Universidad De Concepcion, Chile Disclosures: Ji-Myung Bae, None

SA0232

Protection of Bone Loss by Targeting of Semaphorin 4D Expressed by Osteoclasts Takako Koga*1, Masahiro Shinohara2, Hiroshi Takayanagi 1. 1Tokyo Medical & Dental University, Japan, 2Tokyo Medical & Dental University, Jpn Disclosures: Takako Koga, None

SA0233

R-spondin 2 is a New Key Player in Human Osteoarthritis Osteoblasts to Orchestrate Their Abnormal Canonical Wnt Signaling Elie Abed*1, Thomas Chan1, Aline Delalandre 1, Johanne Martel-Pelletier 1, Jean-Pierre Pelletier1, Daniel Lajeunesse2. 1CHUM, Hoˆpital Notre-Dame, Canada, 2CRCHUM, Hoˆpital Notre-Dame, Canada Disclosures: Elie Abed, None

SA0234

Time Course of Bone Response to Smoke Exposure in Cortical Bone Diane Cullen*1, Bryan Hackfort1, Gwendolin Alvarez1, Sara Rousch1, Meredith Stein1, Mohammed Akhter2. 1Creighton University, USA, 2Creighton University Osteoporosis Research Center, USA Disclosures: Diane Cullen, None

SA0235

Vitamin D Signaling in Osteoblasts/Osteocytes Is Required to Shift Calcium from Bone to Serum Liesbet Lieben*1, Karen Moermans1, Lynda Bonewald2, Jian Feng3, Geert Carmeliet1. 1 Katholieke Universiteit Leuven, Belgium, 2University of Missouri - Kansas City, USA, 3 Texas A&M Health Science Center, USA Disclosures: Liesbet Lieben, None

OSTEOBLASTS: GENE EXPRESSION AND TRANSCRIPTION FACTORS SA0236

A Program of MicroRNAs Controls Osteogenic Lineage Progression by Targeting Transcription Factor RUNX2 Ying Zhang*1, Rong-lin Xie 2, Carlo Croce3, Janet Stein2, Jane Lian2, Andre Van Wijnen2, Gary Stein2. 1Umass medical school, USA, 2University of Massachusetts Medical School, USA, 3The Ohio State University, USA Disclosures: Ying Zhang, None

SA0237

Bone-specific Overexpression of NPY Modulates Osteogenic Differentiation. Igor Matic*1, John Igwe2, Dario Repic1, Slavica Pejda3, Tomislav Kizivat4, Douglas Adams1, Ivo Kalajzic1. 1University of Connecticut Health Center, USA, 2Department of Orthopedic Surgery, University of Connecticut Health Center, USA, 3University of Connecticut, USA, 4Croatia Disclosures: Igor Matic, None

82

SA0238

Collagen-Mimetic Peptide of Adiponectin Accelerates Osteoblastic Differentiation Aiko Kamada*, Takashi Ikeo, Yoshihiro Yoshikawa, Eisuke Domae, Seiji Goda, Isao Tamura. Osaka Dental University, Japan Disclosures: Aiko Kamada, None

SA0239

Differential Expression of Nuclear Receptors and Coregulators in Mouse Calvarial Osteoblast Differentiation and in Aged Mice Matthew Roforth*1, Sundeep Khosla2, David Monroe3. 1Mayo Clinic, USA, 2College of Medicine, Mayo Clinic, USA, 3Mayo Foundation, USA Disclosures: Matthew Roforth, None

SA0240

Effect of Nanocoating with Rhamnogalacturonan-I on Surface Properties and Osteoblasts Response Katarzyna Gurzawska* 1, Rikke Svava2, Susanne Syberg3, Yu Yihua4, Kenneth Brian Haugshøj 5, Iben Damager6, Leif Højslet Christensen5, Peter Ulvskov Ulvskov6, Klaus Gotfredsen 7, Niklas Jorgensen8. 1Research Center for Ageing & Osteoporosis, University of Copenhagen, Glostrup Hospital, Denmark, 2Copenhagen Center for Glycomisc, Faculty of Health Sciences, University of Copenhagen, Denmark, 3Glostrup Hospital, Denmark, 4 Microtechnology & surface analysis, Danish Technological Institute, Gregersensvej 3, 2630 Taastrup, Denmark, Denmark, 5Microtechnology & surface analysis, Danish Technological Institute, Denmark, 6Department of Plant Biology, Faculty of Life Sciences, University of Copenhagen, Denmark, 7 Institute of Odontology, Faculty of Health Sciences, University of Copenhagen, Denmark, 8Copenhagen University Hospital Glostrup, Denmark Disclosures: Katarzyna Gurzawska, None

SA0241

Disclosures: Amelia Baker, None SA0242

Epigenetic Regulation of Mesenchymal Cell Commitment to the Osteoblast Lineage by Dlx3 Jonathan Gordon*1, Mohammad Hassan1, Hai Wu1, Maria Morasso2, Andre Van Wijnen1, Janet Stein1, Gary Stein1, Jane Lian1. 1University of Massachusetts Medical School, USA, 2Developmental Skin Biology Section, NIAMS/NIH, USA Disclosures: Jonathan Gordon, None

SA0243

Expression of Dlx3 in Neural Crest-derived Cells Is Essential for Normal Formation of Craniofacial Bones Olivier Duverger1, Juliane Isaac*1, Anne K. Bartels1, Angela Zah1, Jane Lian 2, Ariane Berdal3, Joonsung Hwang1, Maria I. Morasso1. 1Developmental Skin Biology Section, NIAMS/NIH, USA, 2University of Massachusetts Medical School, USA, 3INSERM, UMRS 872, Universites Paris 5 & 6, Team 5, France Disclosures: Juliane Isaac, None

SA0244

Identification of a Common BMP-responsive Element in the Id1, Id2 and Id3 Genes Masashi Shin*1, Satoshi Ohte1, Katsumi Yoneyama 1, Hiroki Sasanuma1, Shoichiro Kokabu2, Toru Fukuda3, Eijiro Jimi4, Takenobu Katagiri5. 1Saitama Medical University, Japan, 2Harvard School of Dental medicine, USA, 3Keio University School of Medicine, Japan, 4Kyushu Dental College, Japan, 5Saitama Medical University Research Center for Genomic Medicine, Japan Disclosures: Masashi Shin, None

SA0245

Identification of a Transcriptional Network Associated with Osteoblast Activity Using Systems Genetics Charles Farber*1, Ana Lira1, Brian Bennett2, Luz Orozco2, Hyun Kang2, Calvin Pan2, Eleazar Eskin2, Aldons Lusis2. 1University of Virginia, USA, 2University of California, Los Angeles, USA Disclosures: Charles Farber, None

83

Saturday

Environment Contaminant Tributyltin-Induced Osteoporosis: Distinct Involvement of PPARc and RXR in Suppression of Osteogenesis Amelia Baker*1, Brett D Meeks 1, Faye V. Andrews2, Danielle Salazar 1, Louis Gerstenfeld1, Jennifer Schlezinger 3. 1Boston University School of Medicine, USA, 2Boston University School of Public Health, USA, 3Boston University School of Public Health, USA

SA0246

Nanog Promotes Osteogenic Differentiation of Mesenchymal Cells By Modulating Bone Morphogenetic Protein (BMP) Signaling Toru Ogasawara*1, Shinsuke Ohba2, Fumiko Yano3, Hiroshi Kawaguchi4, Takahiro Abe1, Tsuyoshi Takato1, Kazuto Hoshi1. 1University of Tokyo, Japan, 2The University of Tokyo Graduate School of Medicine, Japan, 3The University of Tokyo, Japan, 4University of Tokyo, Faculty of Medicine, Japan Disclosures: Toru Ogasawara, None

SA0247

New AIS Candidate Gene Identification through Microarray Gene Expression Profiling Khaled Fendri*1, Shunmoogum Shunmoogum 2, Charlotte Zaouter3, Stefan Paent2, Florina Moldovan4. 1University of Montral, Canada, 2university of Montreal, Canada, 3CHU Sainte-Justine, Canada, 4Montreal University, Canada Disclosures: Khaled Fendri, None

SA0248

Odd-skipped Related1 and Odd-skipped Related2 are Mutually Regulated Shinji Kawai*, Atsuo Amano. Osaka University Graduate School of Dentistry, Japan Disclosures: Shinji Kawai, None

SA0249

Osteoblast-specific Transcription Factor Osterix (Osx) Is an Upstream Regulator of Satb2 During Bone Formation Chi Zhang*, Wanjin Tang, Yang Li, Lindsey Orsini. Bone Research Laboratory, Texas Scottish Rite Hospital, USA Disclosures: Chi Zhang, None

SA0250

Overexpression of Transcription Factor Pitx1 Inhibits Osteoblast Differentiation and Bone Mineralization Alain Moreau*1, Nancy Karam2, Anita Franco3. 1Sainte-Justine Hospital, Canada, 2 Sainte-Justine University Hospital Research Center, Canada, 3Sainte-Justine-University Hospital Research Center, Canada Disclosures: Alain Moreau, None

SA0251

Regulation by TNF-a of Beta 2 Adrenergic Receptor Expression in Osteoblasts Kyunghwa Baek*, Hyorin Hwang, Hyerim Lee, Hyunjung Park, Arang Kwon, Jeonghwa Baek. Seoul national university, School of dentistry, South Korea Disclosures: Kyunghwa Baek, None

OSTEOBLASTS: HORMONAL REGULATION AND SIGNAL TRANSDUCTION SA0252

Activation of Distinct Nucleotide Receptor Subtypes Determines the Duration of CalciumNFATc1 Signaling in Osteoblasts over a Remarkably Wide Dynamic Range of ATP Concentrations: A Novel Mechanism for Dose-to-Duration Coupling Matthew Grol*1, Shu Xing2, Alexey Pereverzev1, Stephen M. Sims1, Svetlana Komarova2, S. Jeffrey Dixon1. 1The University of Western Ontario, Canada, 2McGill University, Canada Disclosures: Matthew Grol, None

SA0253

PTH differentially regulates PRG expression in Osteoblasts Hyewon Choi*1, Clara Magyar1, Guillermo Arellano2, Olga Bezouglaia1, Jeanne Nervina3, Sotirios Tetradis4. 1University of California, Los Angeles, USA, 2University of Nevada, Las Vegas, USA, 3University of Michigan, USA, 4UCLA, USA Disclosures: Hyewon Choi, None

SA0254

The p38a MAPK Regulates Osteoblast Function and Postnatal Bone Acquisition Cyril Thouverey1, Joseph Caverzasio*2. 1Division of Bone Diseases, Switzerland, 2Division Bone Diseases, Switzerland Disclosures: Joseph Caverzasio, None

SA0255

WNT5A Is a Novel Regulator of Cytokine and Chemokine Expression In Bone Marrow Stromal Cells Martina Rauner*1, Nicola Stein2, Maria Winzer2, Claudia Goettsch3, Lorenz Hofbauer4. 1 Medical Faculty of the TU Dresden, Germany, 2Technical University Dresden, Department of Medicine III, Germany, 3Department of Medicine III, Technical University, Dresden, USA, 4Dresden Technical University Medical Center, Germany Disclosures: Martina Rauner, None

84

OSTEOBLASTS: PROGENITOR AND STROMAL CELLS, PROLIFERATION AND DIFFERENTIATION SA0256

In Vitro Hematopoiesis and osteoblastogenesis with Marrow from SAMP6 and SAMR1 mice Regina O’Sullivan*1, Joel Greenberger2, Shaonan Cao3, Michael Epperly3, Julie Glowacki1. 1Brigham & Women’s Hospital, USA, 2University of Pittsburgh School of Medicine, USA, 3University of Pittsburgh, USA Disclosures: Regina O’Sullivan, None

SA0257

A Novel Role of PlexinA2 in Regulation of BMP-2 Signaling and Osteoblast Differentiation Yong Deok Lee*, Ji-Eun Oh, Hyung Joon Kim, Woo-Shin Kim, Youngkyun Lee, HongHee Kim. Seoul National University, South Korea Disclosures: Yong Deok Lee, None

SA0258

Challenges in Identifying Human Bone Cell Differentiation in Murine Models of Skeletal Repair Xiaonan Xin*, Xi Jiang, Liping Wang, Alexander Lichtler, David Rowe. University of Connecticut Health Center, USA Disclosures: Xiaonan Xin, None

SA0259

Connexin43 (Cx43) in Osteogenic Cells Regulates Osteoclastogenesis via Paracrine Osteoprotegerin (OPG) Production, without Direct Osteoblast-Osteoclast Gap Junctional Communication Marcus Watkins*, Roberto Civitelli. Washington University in St. Louis School of Medicine, USA Disclosures: Marcus Watkins, None

SA0260

Disclosures: Mohammad Shahnazari, None SA0261

Development of a Fluorescent High-throughput CFU-O assay for a High Content Imaging Platform. Jeffrey Kiernan*, Cheryl Cui, William Stanford. University of Toronto, Canada Disclosures: Jeffrey Kiernan, None

SA0262

Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells Nick Van Gastel*1, Scott Roberts2, Sophie Torrekens1, Jan Schrooten 1, Frank Luyten3, Geert Carmeliet1. 1KATHOLIEKE UNIVERSITEIT LEUVEN, Belgium, 2KULEUVEN, Belgium, 3University Hospitals KU Leuven, Belgium Disclosures: Nick Van Gastel, None

SA0263

Immunohenotype and Functional Comparison of Osteoblast Progenitors from Human Embryonic Stem Cells and Bone Marrow Melissa Stemig*, Mohammad Islam. University of Minnesota School of Dentistry, USA Disclosures: Melissa Stemig, None

SA0264

Ionizing Radiation-Induced Senescent Bone Marrow Stromal Cells Show Reduced Functions Essential for Hematopoietic Stem Cell Engraftment ´ AL - CHU Cynthia Carbonneau*, Christian Beause´jour. UNIVERSITE´ DE MONTRE STE-JUSTINE, Canada Disclosures: Cynthia Carbonneau, None

SA0265

Irradiation-induced DNA Damage Interferes with Mesenchymal Stem Cell Plasticity Genevieve Despars*1, Cynthia Carbonneau2, Oanh Leˆ3, Christian Beause´jour3. 1Centre De ´ AL - CHU STERecherche De L’Hopital St. Jus, Canada, 2UNIVERSITE´ DE MONTRE JUSTINE, Canada, 3Universite´ de Montre´al, Canada Disclosures: Genevieve Despars, None

85

Saturday

CXCR4 Signaling in Osteoblasts is Essential for Bone Homeostasis Vivian Chu1, Mohammad Shahnazari*2, Thomas Wronski3, Bernard Halloran1. 1VA Medical Center (111N), USA, 2UCSF VA Medical Center, USA, 3University of Florida, USA

SA0266

Mitochondrial Superoxide Dismutase Regulates Proliferation and Differentiation of Osteoblasts Keiji Kobayashi*1, Yoshitomo Saita2, Hidetoshi Nojiri2, Daichi Morikawa1, Kenji Watanabe 3, Kouichi Nakasone1, Kazuo Kaneko2, Takahiko Shimizu1. 1Morecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan, 2Department of Orthopaedics, Juntendo Univ., Japan, 3Morecular Gerontology, Tokyo Metropolitan Institute of Gerontolog, Japan Disclosures: Keiji Kobayashi, None

SA0267

PPR-Dependent Signaling in the Osteoblast Lineage Regulates Bone Marrow B Cell Development Cristina Panaroni*1, Rhiannon Chubb1, Joy Wu2. 1Endocrine Unit, Massachusetts General Hospital, USA, 2Massachusetts General Hospital, USA Disclosures: Cristina Panaroni, None

SA0268

The Host Immune Response to Allogeneic and Syngeneic Mesenchymal Stem Cells Modulates Osteogenesis Scott Yang*, Vedavathi Madhu, Abhijit Dighe, Gary Balian, Quanjun Cui. University of Virginia, USA Disclosures: Scott Yang, None

SA0269

2011 ASBMR YOUNG INVESTIGATOR AWARD Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevent Bone Loss in Ovariectomized Nude Mice Jee Hyun An*1, Jung Ah Song1, Kyoung Ho Ki 1, Sol Ip Jung1, Jae-Yeon Yang1, Hyung Jin Choi1, Sun Wook Cho2, Sang Wan Kim3, Seong Yeon Kim1, Soo Jin Choi4, Wonil Oh4, Chan Soo Shin 1. 1Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 2University of Michigan School of Dentistry, USA, 3Seoul National University Boramae Hospital, South Korea, 4Biomedical Research Institute, MEDIPOST, Co., Ltd., South Korea Disclosures: Jee Hyun An, None

OSTEOBLASTS: STEROID/SERM EFFECTS SA0270

Estrogen Treatment Early in Differentiation Promotes Osteoblastic Nodule Formation in Murine Cortical Bone Cells Kumar Chokalingam*1, Sundeep Khosla2, David Monroe3. 1Mayo Clinic, USA, 2College of Medicine, Mayo Clinic, USA, 3Mayo Foundation, USA Disclosures: Kumar Chokalingam, None

OSTEOCLASTS: CATHEPSINS AND OTHER PROTEINASES SA0271

Collagen as a Stop Signal for Osteoclastic Bone Resorption: an Extension of Chambers’ Hypothesis Kent Soe*1, Ditte M.H. Merrild1, Jean-Marie Delaisse2. 1Vejle Hospital, University of Southern Denmark, Denmark, 2Vejle Hospital, CSFU-IRS, University of Southern Denmark, Denmark Disclosures: Kent Soe, None

OSTEOCLASTS: CELL ADHESION SA0272

Genetic Ablation of CD68 Results in Increased Bone in Mice and Abnormal Osteoclasts in Vitro Jason Ashley*1, Zhenqi Shi1, Haibo Zhao2, Robert Kesterson1, Xu Feng1. 1University of Alabama at Birmingham, USA, 2University of Arkansas for Medical Sciences, USA Disclosures: Jason Ashley, None

SA0273

Spatiotemporal Dynamics of Cytosolic Calcium in Osteoclasts: Distinct Patterns Associated with Lamellipod Extension and Uropod Retraction Benjamin D. Wheal*1, Natsuko Tanabe2, S. Jeffrey Dixon1, Stephen Sims1. 1The University of Western Ontario, Canada, 2Nihon University School of Dentistry, Japan Disclosures: Benjamin D. Wheal, None

86

SA0274

The Association Between The Microtubule Plus End Protein EB1 And Cortactin Controls Podosomes And Bone Resorption Martin Biosse Duplan*1, Sebastien Stephens1, Frank PL Lai2, Margit Oelkers3, Daisuke Kitamura4, Klemens Rottner3, William Horne1, Roland Baron5. 1Harvard School of Dental Medicine, USA, 2Institute of Medical Biology, Immunos, Singapore, 3Institute of Genetics, University of Bonn, Germany, 4Research Institute for Biological Sciences, Tokyo University of Science, Japan, 5Harvard School of Medicine & of Dental Medicine, USA Disclosures: Martin Biosse Duplan, None

OSTEOCLASTS: CYTOKINES AND GROWTH FACTORS SA0275

Deletion of CD74, a Putative MIF Receptor, in Mice Enhances Osteoclastogenesis and Decreases Bone Mass. SE HWAN MUN*, Paula Hernadez, Hector Aguila, Sun-Kyeong Lee. University of Connecticut Health Center, USA Disclosures: SE HWAN MUN, None

SA0276

IL-22 Promotes Osteoclastogenesis in Rheumatoid Arthritis Through Induction of RANKL from Synovial Fibroblasts Kyoung-Woon Kim1, Sang-Heon Lee*2, Young-Il Seo 3. 1Konkuk University, South Korea, 2Konkuk University Medical Center, South Korea, 3Hallym University Medical Center, South Korea Disclosures: Sang-Heon Lee, None

SA0277

Disclosures: Erik Lubberts, None SA0278

Regulatory Expression of Mitf-E as an Inducer of Osteoclastogenesis by the TGF-b family Kumiko Asai1, Masayuki Funaba2, Ryo Ooishi1, Masaru Murakami*1. 1Azabu University School of Veterinary Medicine, Japan, 2Kyoto University Graduate School of Agriculture, Japan Disclosures: Masaru Murakami, None

SA0279

Unique RANKL Determinants Associated with RANK Versus OPG Engagement Julia Warren*, Christopher Nelson, Yik Yu, Steven Teitelbaum, Daved Fremont. Washington University in St. Louis School of Medicine, USA Disclosures: Julia Warren, None

OSTEOCLASTS: DIFFERENTIATION SA0280

Analysis of Regulatory Mechanism of Mouse RANK Gene Expression through AP-1 Response Element Riko Kitazawa*1, Satomi Kinto 1, Junko Ishii 1, Takeshi Kondo1, Kiyoshi Mori 1, Sohei Kitazawa2. 1Kobe University Graduate School of Medicine, Japan, 2Ehime University, Japan Disclosures: Riko Kitazawa, None

SA0281

Apoptotic Osteocytes Promote In Vitro Osteoclastogenesis Directly through RANKL and Indirectly Through M-CSF and VEGF Saja Al-Dujaili* 1, Esther Lau 1, Axel Guenther1, Lidan You2. 1University of Toronto, Canada, 2Mechanical & Industrial Engineering, University of Toronto, Canada Disclosures: Saja Al-Dujaili, None

SA0282

Changes in Extracellular Calcium Concentration Affect Human Osteoclast Formation and Bone-Resorbing Activity Francesca Hemingway1, Xiaotong Cheng*2, Nicholas Athanasou2. 1Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, United Kingdom, 2University of Oxford, United Kingdom Disclosures: Xiaotong Cheng, None

87

Saturday

Primary human CCR6+ memory Th17 cells activate synovial fibroblasts leading to a proinflammatory profile with joint destructive capacity Erik Lubberts*1, Nadine Davelaar2, Jan Piet van Hamburg2, Edgar Colin2, Patrick Asmawidjaja 2. 1Erasmus MC Univeristy Medical Center, The Netherlands, 2Erasmus MC University Medical Center, Netherlands

SA0283

Diacylglycerol Maintains Bone Homeostasis by Regulating Osteoclast Differentiation and Function Corinne Decker*1, Viviana Cremasco2, Roberta Faccio3. 1Washington University in St. Louis, USA, 2Washington University School of Medicine, USA, 3Washington University in St Louis School of Medicine, USA Disclosures: Corinne Decker, None

SA0284

Dual Osteoclast Precursor and Suppressor Function of a Ly6Chi Population Increased in Murine Inflammatory Arthritis Julia Charles*1, Lih-Yun Hsu2, Erene C. Niemi2, Arthur Weiss2, Mary Nakamura 2. 1 University of California, San Francisco & VA Medical Center, USA, 2University of California, San Francisco, USA Disclosures: Julia Charles, None

SA0285

Dynamic in vivo Imaging of Bone-Resorptive Functions of Mature Osteoclasts in Live Bones By Using Intravital Two-Photon Microscopy Junichi Kikuta*1, Yoh Wada2, Masaru Ishii 1. 1Immunology Frontier Research Center, Osaka University, Japan, 2Institute of Scientific & Industrial Research, Osaka University, Japan Disclosures: Junichi Kikuta, None

SA0286

Effects of Dietary Amino Acids on Expression Levels of Markers of Osteoclastic Differentiation/Activity Qing Zhong*1, Ke-Hong Ding1, Wendy Bollag1, Hugh Nadeau1, Karl Insogna2, Norman Chutkan 1, Mark Hamrick1, Carlos Isales3. 1Georgia Health Sciences University, USA, 2 Yale University School of Medicine, USA, 3Medical College of Georgia, USA Disclosures: Qing Zhong, None

SA0287

Identification and Characterization of OCAN, a Novel Osteoclastogenic Co-activator for NFATc1 Min-Young Youn*1, Sally Fujiyama-Nakamura1, Yuuki Imai1, Shigeaki Kato2. 1The University of Tokyo, Japan, 2University of Tokyo, Japan Disclosures: Min-Young Youn, None

SA0288

Immunostimulatory Lipopeptides, Pam2CSK4 and Pam3CSK4, Enhance Osteoclast Differentiation Jiseon Kim*1, Jihyun Yang2, Ok-Jin Park3, Cheol-Heui Yun4, Hong-Hee Kim1, Seung Hyun Han3. 1Seoul National University, South Korea, 2Department of Oral Microbiology & Immunology, DRI, & BK21 Program, School of Dentistry, Seoul National University, South Korea, 3School of Dentistry, Seoul National University, South Korea, 4Department of Agricultural Biotechnology & Research Institute for Agriculture & Life Sciences, Seoul National University, South Korea Disclosures: Jiseon Kim, None

SA0289

Microtubule Contribution to Osteoclastogenesis – Stathmin Deficiency Induces Low Bone Mass In Mice by Increasing Osteoclastogenesis Hongbin Liu* 1, Rongrong Zhang1, Babatunde Oyajobi2, Hong-Wen Deng1, Ming Zhao1. 1 Tulane University, USA, 2University of Texas Health Science Center at San Antonio, USA Disclosures: Hongbin Liu, None

SA0290

Molecular Basis of the Requirement of RANK Signaling for Interleukin-1 (IL-1)-Mediated Osteoclastogenesis Joel Jules*, Jason Ashley, Ping Zhang, Shi Wei, Zhenqi Shi, Jianzhong Liu, Suzanne Michalek, Xu Feng. University of Alabama at Birmingham, USA Disclosures: Joel Jules, None

SA0291

NIBP: A Novel Regulator of Osteoclast Differentiation and Function Kevin Crawford*1, Joyce Belcher2, Roshanak Razmpour1, Yonggang Zhang3, Wen-Hui Hu3, Steven Popoff1, Fayez Safadi1. 1Temple University School of Medicine, USA, 2 Temple University, School of Medicine, USA, 3Temple University School of Medicine Department of Neuroscience, USA Disclosures: Kevin Crawford, None

88

SA0292

Osteoclasts in Bone Modeling, As Revealed By In Vivo Imaging, Are Essential for Organogenesis in Fish Masahiro Chatani*1, Yoshiro Takano2, Akira Kudo1. 1Tokyo institute of technology, Japan, 2Tokyo Medical & Dental University, Japan Disclosures: Masahiro Chatani, None

SA0293

Runt-related transcription factor 1 (Runx1) Regulates Macrophage/Osteoclast Lineage Commitment and Osteoclast Differentiation Wei Chen, Yi-Ping Li*. University of Alabama at Birmingham, USA Disclosures: Yi-Ping Li, None

SA0294

The Alpha2 Integrin Minimally Impacts Osteoclast Differentiation and Adult Bone Homeostasis Zhengyan Wang*1, Grace Shin1, Eric Everett2, Xin Li 3, Mary Zutter4, Laurie McCauley5. 1 University of Michigan, USA, 2University of North Carolina at Chapel Hill, USA, 3New York University, USA, 4Department of Pathology, Vanderbilt University Medical Center, USA, 5University of Michigan, School of Dentistry, USA Disclosures: Zhengyan Wang, None

SA0295

Thrombospondin-1 Regulates Bone Density Through Effects on Nitric Oxide Signaling in Osteoclasts Sarah Amend*1, Ozge Uluckan2, Michelle Hurchla1, Hongju Deng2, William Frazier2, Katherine Weilbaecher2. 1Washington University in St. Louis, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Sarah Amend, None

SA0296

Disclosures: Tingting Zhu, None

OSTEOCLASTS: INHIBITION OF RESORPTION SA0297

Calmodulin Interacts with Rab3D and Mediates Osteoclastic Bone Resorption Jiake Xu*1, Taksum Cheng2, Shek Man Chim2, Jennifer Tickner2, Estabelle Ang1, Ming Hao Zheng2, Nathan Pavlos1. 1The University of Western Australia, Australia, 2University of Western Australia, Australia Disclosures: Jiake Xu, None

SA0298

Does Ovariectomy in Non-Resorbing Adult Mice Cause Bone Gain? Christian Thudium*1, Carmen Flores2, Ilana Moscatelli2, Jesper Thomsen3, Mie Bru¨el 4, Natalie Sims5, Maria Askmyr6, Thomas Martin6, Anita Neutzsky-Wulff7, Vicki Jensen8, Gerling Langenbach9, Claus Christiansen8, Vincent Everts9, Morten Karsdal8, Johan Richter2, Kim Henriksen8. 1Nordic Bioscience, Denmark, 2Lund University, Sweden, 3 University of Aarhus, Denmark, 4Institute of Anatomy, University of Aarhus, Denmark, 5 St. Vincent’s Institute of Medical Research, Australia, 6St. Vincent’s Institute for Medical Research, Australia, 7Nordic Bioscience & University of Copenhagen, Denmark, 8Nordic Bioscience A/S, Denmark, 9Dept. Oral Cell Biology, (ACTA), Universiteit van Amsterdam & Vrije Universiteit, Netherlands Disclosures: Christian Thudium, None

SA0299

IL-17 Mediates Estrogen-deficient Osteoporosis Carl DeSelm*1, Yoshifumi Takahata2, Jean Chappel2, Taimur Khan2, Xiaoxia Li 3, Wei Zou4, Steven Teitelbaum4. 1Washington University School of Medicine, USA, 2Washington University in St. Louis, USA, 3Cleveland Clinic, USA, 4Washington University in St. Louis School of Medicine, USA Disclosures: Carl DeSelm, None

89

Saturday

Type I Phosphoinositide-4 Phosphate 5 Kinasec Regulates Osteoclasts in a Bifunctional Manner Tingting Zhu*1, Robert Mecham2, Pietro De Camilli 3, Jean Chappel4, Steven Teitelbaum4, Wei Zou4. 1Washington University in St. Louis-School of Medicine, USA, 2Washington University School of Medicine, USA, 3Yale University School of Medicine, USA, 4 Washington University in St. Louis School of Medicine, USA

SA0300

Lysophosphatidylinositol: Evidence for a Role in GPR55 Mediated Bone Resorption and Rheumatoid Arthritis Lauren S. Whyte*, Wendy R. Russell, Lynne Hocking, Michael Rogers, Ruth A. Ross. University of Aberdeen, United Kingdom Disclosures: Lauren S. Whyte, None

SA0301

Silicon Nanocrystal Tracer for Real-Time Activity Bioassay of Single Osteoclasts Naif Alsharif, Mark Birch, Benjamin Horrocks, Harish Datta*. Newcastle University, United Kingdom Disclosures: Harish Datta, None

SA0302

Tctex-1, a Novel Interaction Partner of Rab3D, is Required for Osteoclastic Bone Resorption Nathan Pavlos*1, Taksum Cheng2, An Qin2, PeiYing Ng1, Hao-Tian Feng1, Estabelle Ang1, Amerigo Carrello1, Ching-Hwa Sung3, Reinhard Jahn4, Ming Hao Zheng2, Jiake Xu1. 1The University of Western Australia, Australia, 2University of Western Australia, Australia, 3Cornell University, USA, 4Max-Planck-Institute for Biophysical Chemistry, Germany Disclosures: Nathan Pavlos, None

SA0303

The ADP receptor P2Y12 Regulates Osteoclast Function and Pathologic Bone Loss Xinming Su*1, Desiree Floyd2, alun hughes3, Kaiming Wu2, Ozge Uluckan2, Sarah Townsley2, Angela Hirbe2, Jochen Schneider4, Emanuella Heller2, Michelle Hurchla2, Hongju Deng2, Mark Eagleton2, Deborah Novack5, Pamela Conley2, Michael Rogers3, Katherine Weilbaecher5. 1Washington University in Saint Louis, USA, 2Washington University in St. Louis, USA, 3University of Aberdeen, United Kingdom, 4Washu, USA, 5 Washington University in St. Louis School of Medicine, USA Disclosures: Xinming Su, None

SA0304

TRAF family member-associated Nf-kappa B activator (Tank), Induced by RANKL, Negatively Regulates Osteoclast Survival and Function Mengrui Wu*1, Lianfu Deng2, Yiping Wang3, Wei Chen4, Xu Feng4, Yi-Ping Li 4. 1Institute of Genetics, Life Science College, Zhejiang University & Department of Pathology, University of Alabama at Birmingham, China, 2Shanghai Key laboratory, Shanghai Institute of Trauma & Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai JiaoTong University, China, 3Institute of Genetics, Life Science College, Zhejiang University, China, 4University of Alabama at Birmingham, USA Disclosures: Mengrui Wu, None

OSTEOCLASTS: SIGNAL TRANSDUCTION SA0305

P21Ras Mediated Activation of PI3K Results in Enhanced Survival of Osteoclasts in the Absence of Cbl-PI3K Interaction Independent of Cbl-b Nagasuresh Adapala*1, Alexander Tsygankov2, Mary Barbe1, Archana Sanjay1. 1Temple University School of Medicine, USA, 2Temple University, USA Disclosures: Nagasuresh Adapala, None

SA0306

Selective Deletion of Rac1 and Rac2 in Mature Osteoclasts Results in Osteopetrosis, Failed Tooth Eruption and Defects in both Osteoclast and Osteoblast Function Meiling Zhu*1, Ben-hua Sun1, Katarzyna Kolodziejczak1, Karl Insogna2. 1Yale University, USA, 2Yale University School of Medicine, USA Disclosures: Meiling Zhu, None

SA0307

The Rho-GEF Kalirin Regulates Dynamin’s GTPase Activity and Osteoclast Function Pierre Eleniste*, Su Huang, Heather Largura, Angela Bruzzaniti. Indiana University School of Dentistry, USA Disclosures: Pierre Eleniste, None

OSTEOCYTES: REGULATION OF BONE FORMATION SA0308

Both VEGF Receptor 2 (VEGFR2) and the Parathyroid Hormone Type 1 Receptor (PTH1R) Mediate the Early Antiapoptotic Response to Mechanical Stimulation in MLO-Y4 Cells Marta Maycas*1, Luis Fernandez de Castro1, Beatriz Bravo1, Cira Garcia de Durango1, Jose Manuel Pozuelo1, Pedro Esbrit2, Arancha Gortazar3. 1Universidad San Pablo CEU, Spain, 2FUNDACION JIMENEZ DIAZ, Spain, 3Universidad San Pablo-CEU School of Medicine Madrid Spain, Spain Disclosures: Marta Maycas, None

90

SA0309

Constitutive Protein Kinase A Activities in Osteocytes Leads to Increased Bone Formation without Increased Bone Resorption Richard Kao*1, Wei-Dar Lu2, Dylan O’Carroll2, Peter Mailhot2, Robert Nissenson 3. 1 UCSF/VAMC, USA, 2VA Medical Center, USA, 3VA Medical Center & University of California, San Francisco, USA Disclosures: Richard Kao, None

SA0310

2011 ASBMR YOUNG INVESTIGATOR AWARD Estrogen Receptor a (ERa) Expression in Osteocytes is Necessary to Maintain Normal Bone Mineral Density (BMD) and Reduce Bone Loss due to Unloading Yuuki Imai1, Lynda Bonewald2, Shino Kondoh*1, Shigeaki Kato3. 1The University of Tokyo, Japan, 2University of Missouri - Kansas City, USA, 3University of Tokyo, Japan Disclosures: Shino Kondoh, None

SA0311

NFATc1 Expression in Osteocytes Regulates Bone Formation by Regulating Sclerostin Expression Todd Spears*1, Jennifer Paige-Robinson2, Majd Zayzafoon1. 1University of Alabama at Birmingham, USA, 2University of Alabama-Birmingham, USA Disclosures: Todd Spears, None

SA0312

Pharmacological Activation of Canonical Wnt Signaling Improves Bone Homeostasis and Regeneration by Directly Promoting MSC Osteoblast Differentiation Tripti Gaur*1, John Wixted1, Sadiq Hussain1, Jennifer Colby1, Mary Clare McCorry1, Stacey Russell1, Ellen Gravallese1, Andre Van Wijnen1, Ivo Kalajzic2, David Rowe2, Janet Stein1, Gary Stein1, Jane Lian 1. 1University of Massachusetts Medical School, USA, 2 University of Connecticut Health Center, USA Disclosures: Tripti Gaur, None

Regulation of Osteocyte Apoptosis and ECM by PTHrP Leonard Deftos*1, Cheryl Chalberg2, Su Tu2, Douglas Burton3, Lynda Bonewald4. 1 Veterans Administration San Diego Healthcare System & University of California, USA, 2 VA San Diego Healthcare System / University of California San Diego, USA, 3VA San Diego Healthcare System / University of California, San Diego, USA, 4University of Missouri - Kansas City, USA Disclosures: Leonard Deftos, None

OSTEOCYTES: REGULATION OF BONE MINERALIZATION SA0314

Hypermineralization of Osteocyte Lacunae in the Aged Human Skeleton Leads to Underestimated Osteocyte Lacunar Densities Vincent Carpentier, Jinquan Wong, Youwen Yeap, Cheryl Gan, Peter Sutton-Smith, Arash Badiei, Nicola Fazzalari, Julia Kuliwaba*. SA Pathology, Australia Disclosures: Julia Kuliwaba, None

SA0315

PTH Regulation of SOST and FGF23 in Novel Osteocytic Cell Lines Jordan Spatz*1, J Martorell2, KJ Barry3, ER Edelman4, M Balcells5, Paola Pajevic Divieti6. 1 Harvard-MIT Division of Health Sciences & Technology (HST), USA, 2Massachussetts Institute of Technology & Institut Quimic de Sarria, Barcelona, Spain, USA, 3Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, USA, 4Massachusetts Institute of Technology & Cardiovascular Division, Department of Medicine, Brigham & Women’s Hospital, USA, 5Massachussetts Institute of Technology & Institut Quimic de Sarria, Barcelona, Spain, USA, 6MGH- Harvard Medical School, USA Disclosures: Jordan Spatz, None

SA0316

The Formation and the Mineral Content of Hypermineralized Osteocyte Lacunae: the Phenomenon of Osteocyte Hypermineralization a Single State or a Matter of Degree? Vincent T. Carpentier*, Jinquan Wong, Youwen Yeap, Cheryl Gan, Peter Sutton-Smith, Arash Badiei, Nicola L. Fazzalari, Julia S. Kuliwaba. SA Pathology & Hanson Institute, Australia Disclosures: Vincent T. Carpentier, None

91

Saturday

SA0313

OSTEOCYTES: REGULATION OF MINERAL ION HOMEOSTASIS SA0317

Association of the a2d1 Subunit with Cav3.2 Enhances Membrane Expression and Regulates Mechanically-Induced ATP Release and ERK1/2 Signaling in Osteocytes William Thompson* 1, Amber Majid2, Kirk Czymmek2, Albert Ruff3, Jesu´s Garcı´a 4, Randall Duncan1, Mary Farach-Carson5. 1University of Delaware, USA, 2University of Delaware, Department of Biological Sciences, USA, 3US Army Medical Research Institute of Chemical Defense, Cell & Molecular Biology Branch, Research Division, USA, 4 University of Illinois at Chicago, Department of Physiology & Biophysics, USA, 5Rice University, USA Disclosures: William Thompson, None

SA0318

Evidence of Fibroblast Growth Factor as a Physiological Regulator of Osteocyte Differentiation; Lessons from Wildtype and Hyp Mice Carolyn Macica*1, Adam Kaye 2, Guoying Liang2. 1Yale University School of Medicine, USA, 2Yale University, USA Disclosures: Carolyn Macica, None

SA0319

2011 ASBMR YOUNG INVESTIGATOR AWARD Evidence that Osteocytes Elaborate Endocrine Regulation of Internal Organs Size: Data From the Osteocytes IGF-I Conditional Knockout Mice Xiaodong Zhou*1, Kin-Hing William Lau2, Lynda Bonewald3, David Baylink1, Matilda Sheng1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3University of Missouri - Kansas City, USA Disclosures: Xiaodong Zhou, None

SA0320

Functional Heterogeneity of Osteocytes in FGF23 Production Revealed by 3-Dimensional Fluorescence Morphometry Ayako Nakane* 1, Rieko Tanabe2, Mayu Haraikawa3, Takashi Watanabe 1, Hiroshi Kamioka4, Masae Goseki-Sone5, Yuzo Takagi6, Akira Yamaguchi 7, Tadahiro Iimura 1. 1 Tokyo Medical & Dental University, Global Center of Excellence Program, Japan, 2 Department of Food & Nutrition, Faculty of Human Sciences & Design, Japan Women’s University, Japan, 3Graduate School of Human Life Science, Japan Women’s University, Japan, 4Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sc, Japan, 5Japan Women’s University, Japan, 6Developmental Oral Health Sciences, Tokyo Medical & Dental University, Japan, 7Tokyo Medical & Dental University, Japan Disclosures: Ayako Nakane, None

OSTEOPOROSIS ASSESSMENT: BIOCHEMICAL MARKERS SA0321

Association Between Lipid Profile and Bone Turnover in Elderly Women and Men Marija Tamulaitiene* 1, Rima Piliciauskiene 2, Vidmantas Alekna1. 1Vilnius University, Lithuania, 2State Research Institute Centre for Innovative Medicine, Lithuania Disclosures: Marija Tamulaitiene, AMGEN, 8; AMGEN, 5; GSK, 8

SA0322

Evaluation of Undercarboxylated Osteocalcin (ucOC) in the Treatment for Osteoporosis: A Clinical Practice-Based Study Yoichi Kishikawa*. Kishikawa Orthopedic Surgery, Japan Disclosures: Yoichi Kishikawa, None

SA0323

Intravenous Zoledronate use in Adult Delayed Non-Union Fracture Healing Nigel Gilchrist*1, David Little2, John McKie1. 1Department of Orthopaedic Medicine & Surgery, Christchurch Hospital, New Zealand, 2The Children’s Hospital At Westmead, Australia Disclosures: Nigel Gilchrist, None

SA0324

Serum Sclerostin Level and its Association with Bone Turn-over Markers in Type 2 Diabetes Megumi Shibata*1, Atsushi Suzuki2, Sahoko Sekiguchi-Ueda 3, Shogo Asano4, Yasumasa Yoshino3, Masaki Makino3, Nobuki Hayakawa3, Mitsuyasu Itoh3. 1Fujita Health University, Division of Endocrinology, Japan, 2Fujita Health University Division of Endocrinology, Japan, 3Fujita Health University, Japan, 4Toyokawa city hospital, Japan Disclosures: Megumi Shibata, None

92

OSTEOPOROSIS ASSESSMENT: BONE MINERAL DENSITY SA0325

Allowing Patient Self-Referral of DXA Significantly Improves Osteoporosis Screening Amy Warriner*1, Ryan Outman2, Jeffrey Curtis 2, Adrianne Feldstein3, David Redden2, Mary Rix 3, Brandi Robinson3, Douglas Roblin3, Ana Rosales3, Monika Safford2, Kenneth Saag2. 1UAB, USA, 2University of Alabama at Birmingham, USA, 3Kaiser Permanente Center for Health Research, USA Disclosures: Amy Warriner, None

SA0326

Bone Loss in Ambulatory Patients with Multiple Sclerosis Vit Zikan*1, Michaela Ty´blova´2, Ivan Raska1, Eva Havrdova2, Dana Michalska1, Zdenek Telicka1. 1Department of Internal Medicine 3, Charles University Faculty of Medicine 1, Czech Republic, 2Department of Neurology, Charles University Faculty of Medicine 1, Czech Republic Disclosures: Vit Zikan, None

SA0327

Degenerative Changes at the Lumbar Spine - Implications for Bone Mineral Density Measurement in Elderly Women Kristina Akesson*1, Max Tenne 2, Jack Besjakov3, Paul Gerdhem 4, Fiona McGuigan5. 1 Ska˚ne University Hospital, Malmo¨, Sweden, 2Clinical & Molecular Osteoporosis Research Unit, Department of Clinical Science Malmo, Lund University, Sweden, 3Dept of Radiology Malmo¨, Ska˚ne University Hospital, Malmo¨, Sweden, 4Karolinska Institutet, Sweden, 5University of Lund, Malmo¨, Skane University Hospital, Malmo¨, Sweden Disclosures: Kristina Akesson, None

SA0328

Disclosures: Eugene McCloskey, None SA0329

Estimation of Fracture Probability of Glucocorticoid-Induced Osteoporosis by a Logistic Regression Model Ikuko Tanaka*1, Shigenori Tamaki2, Hisaji Oshima3. 1National Center for Geratrics & Gerontology, Japan, 2Nagoya Rheumatology Clinic, Japan, 3Tokyo Medical Center, Japan Disclosures: Ikuko Tanaka, None

SA0330

Forearm BMD Measurement Variability Using DXA Diane Krueger*1, Nellie Vallarta-Ast2, Jessie Libber3, Mary Checovich1, Neil Binkley3. 1 University of Wisconsin, Madison, USA, 2UW Osteoporosis Research, USA, 3University of Wisconsin, USA Disclosures: Diane Krueger, None

SA0331

Rate of BMD Change Does Not Enhance Fracture Prediction: The Manitoba BMD Cohort William Leslie*1, Suzanne Morin2, Lisa Lix3. 1University of Manitoba, Canada, 2McGill University Health Centre, Canada, 3University of Saskatchewan, Canada Disclosures: William Leslie, None

SA0332

The Discriminatory Capacity of Clinical Risk Factors and BMD Measurements at Different Skeletal Sites for Detecting Patients with Vertebral Fractures Christian Muschitz* 1, Friederike Kuehne2, Roland Kocijan3, Angela Trubrich2, Christina Bittighofer 2, Reinhart Waneck4, Heinrich Resch5. 1St. Vincent’s Hospital, Austria, 2The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 3 St.Vincent Hospital Vienna, Austria, 4St. Vincent Hospital - Department of Radiology, Austria, 5Medical University Vienna, Austria Disclosures: Christian Muschitz, None

OSTEOPOROSIS ASSESSMENT: BONE STRUCTURE SA0333

Intra-rater Reliability of Dual Energy X-ray Absorptiometry-based Measures of Vertebral Height and Consistency of Vertebral Deformity Classification in Postmenopausal Women Alison M. Bonnyman1, Colin Webber2, Paul W. Stratford1, Norma MacIntyre* 3. 1School of Rehabilitation Science, McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3McMaster University, Canada Disclosures: Norma MacIntyre, None

93

Saturday

Distal Forearm BMD combined with FRAX Probabilities for Fracture Prediction Sreekanth Vasireddy1, Helena Johansson 2, Anders Oden3, Diane Charlesworth1, John Kanis4, Eugene McCloskey*1. 1University of Sheffield, United Kingdom, 2Swedish University of Agricultural Sciences, The Biomedical Center, Sweden, 3University of Gothenberg, Sweden, 4University of Sheffield, Belgium

SA0334

Quantitative Morphometry on Spinal X-Rays: Long-Term Precision of a New Workflow Tool for Measuring Vertebral Body Height in Non-Fractured Vertebrae Klaus Engelke*1, Bernd Stampa1, Peter Steiger 2, Thomas Fuerst3, Harry Genant4. 1Synarc Inc, Germany, 2Optasia Medical, USA, 3Synarc, Inc., USA, 4UCSF/Synarc, USA Disclosures: Klaus Engelke, Synarc, 3

SA0335

Reproducibility of a Vertebral Deformity Tool (VDT) using an Statistical Shape Modeling Workflow Tool Colin Miller*1, Alan Brett2, Eric Bogner3, MONIQUE TAN 4, Rebecca Cope5, Melanie Jenkins6, Jane Haslam7, Joes Staal8, Curtis Hayes 9. 1BioClinica, Inc. (formerly Bio-Imaging Technologies, Inc.), USA, 2Optasia Medical Ltd., United Kingdom, 3Hospital for Special Surgery, USA, 4NOVARTIS PHARMACEUTICAL, USA, 5BioClinica Inc, USA, 6 Novartis Pharmaceuticals, USA, 7Optasia Medical Ltd, United Kingdom, 8Optasia Medical, United Kingdom, 9Virginia Commonwealth University School of Medicine, USA Disclosures: Colin Miller, BioClinica, 3; Novartis Pharmaceuticals, 6

SA0336

Reproducibility of High Resolution Peripheral Quantitative Computed Tomography (HRpQCT): Influence of Examination Site and Age on Measurement Variability Margaret Paggiosi1, Richard Eastell2, Jennifer Walsh*1. 1Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom, 2University of Sheffield, United Kingdom Disclosures: Jennifer Walsh, None

SA0337

Reproducibility of HR-pQCT measurements of the distal radius: influence of casting Martijn de Kooter1, Sandrine Bours*2, Tineke Van Geel3, Chris Arts4, Paul Willems4, Joop Van Den Bergh5, Piet Geusens6, Bert Rietbergen7. 1Eindhoven University of Technology, Netherlands, 2Maastricht University Medical Centre, The Netherlands, 3Maastricht University, The Netherlands, 4Maastricht University, Dept. of Orthopaedic Surgery, Netherlands, 5Maastricht UMC & VieCuri MC Noord-Limburg, USA, 6University Hasselt, Belgium, 7Eindhoven University of Technology, The Netherlands Disclosures: Sandrine Bours, None

OSTEOPOROSIS ASSESSMENT: ULTRASOUND SA0338

Calcaneal Quantitative Ultrasound Compared to Hip and Femoral Neck DXA in People with Spinal Cord Injury Danielle Barkema*1, Nicole Wysocki2, Lisa Streff2, Sheena Bhuva3, Rachel Welbel4, Lisa Ruppert2, Sarah Linn2, Dorian Samuels2, Keith Gordon1, Thomas Schnitzer1. 1 Northwestern University, USA, 2Rehabilitation Institute of Chicago, USA, 3Texas A&M Health Science Center, USA, 4Chicago Medical School, USA Disclosures: Danielle Barkema, None

SA0339

Quantitative Ultrasound Measurements Predict Fracture Risk in Non-osteoporotic Women Tuan Nguyen1, John Eisman1, Jacqueline Center1, Mei Chan*2, Nguyen Nguyen1. 1Garvan Institute of Medical Research, Australia, 2Osteoporosis & Bone Biology, Australia Disclosures: Mei Chan, M & D, Roche and Novartis, 99

SA0340

Quantitative Ultrasound Measurements at the Heel Predict the Risk of Fragility Fractures in Postmenopausal Women and would Save the use of Densitometry. Marı´a Jesu´s Go´mez de Tejada1, Pedro Saavedra1, Diego Herna´ndez2, Esther Gonza´lezPadilla2, Manuel Sosa-Henriquez* 3. 1Professor, Spain, 2Dr., Spain, 3University of Las Palmas de Gran Canaria, Spain Disclosures: Manuel Sosa-Henriquez, None

OSTEOPOROSIS EPIDEMIOLOGY: BONE MINERAL DENSITY SA0341

A Relationship Between Bone Mineral Density and Metabolic Syndrome in Koreans : The Chungju Metabolic Disease Cohort Study Eun Hee Jang1, Moo-Il Kang 2, Sun Hee Ko*3, Ki-Hyun Baek1. 1Division of Endocrinology & Metabolism1 Department of Internal Medicine1, The Catholic University of Korea, South Korea, 2Seoul St. Mary’s Hospital, South Korea, 3The Catholic University of Korea, South Korea Disclosures: Sun Hee Ko, None

94

SA0342

Association of Bone Mineral Density with Insulin Sensitivity Indices in Normoglycemic Men and Women in the Fels Longitudinal Study Naila Khalil*1, Miryoung Lee2, Audrey Choh1, Keith Wurzbacher1, Dana Duren1, Cameron Wm Chumlea1, Bradford Towne1, Roger Siervogel2, Stefan Czerwinski 2. 1Wright State University, USA, 2Wright State University Boonshoft School of Medicine, USA Disclosures: Naila Khalil, None

SA0343

Body Composition and Serum Cholesterol Play the Most Relevant Role on High Bone Mineral Density in Healthy Women, Regardless Physical Activity, Dietary Intake, Bone Remodeling and Menopausal and Vitamin D Status Karin Sarkis*1, Marcelo Pinheiro2, Vera Szejnfeld3, Ligia Martini1. 1University of Sa˜o Paulo, Brazil, 2Sao Paulo Federal University/ Unifesp/ Escola Paulista De Medicina, Brazil, 3 UNIFESF/EPM, Brazil Disclosures: Karin Sarkis, None

SA0344

Correlates of Higher Bone Mineral Density in Inuit Preschoolers Living in the Arctic Jessy Hayek*, Hope Weiler, Grace Egeland. McGill University, Canada Disclosures: Jessy Hayek, None

SA0345

High Prevalence of Osteoporosis in Female Patients Undergoing Total Knee Arthroplasty for Advanced Knee Osteoarthritis Ja-Young Choi1, Chong Bum Chang*2, Tae Kyun Kim3, Eun Seok Seo3. 1Seoul National University Hospital, South Korea, 2Seoul National University Bundang Hospital, Rok, 3 Seoul National University Bundang Hospital, South Korea Disclosures: Chong Bum Chang, None

SA0346

Disclosures: Ana Lirani-Galvao, None SA0347

Peri-Aortic Fat Is Negatively Associated with Volumetric Bone Mineral Density, CrossSectional Area and Compressive Strength of Lumbar Vertebrae: the Framingham Osteoporosis Study Yi-Hsiang Hsu*1, Caroline S. Fox2, Mary Bouxsein3, Udo Hoffmann4, LA Cupples5, Douglas Kiel6. 1Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 2National Heart, Lung, & Blood’s Framingham Heart Study, USA, 3Beth Israel Deaconess Medical Center, USA, 4Massachusetts General Hospital, Department of Cardiac MR PET CT & Harvard University, USA, 5Biostatstics Dept., School of Public Health, Boston University, USA, 6Hebrew SeniorLife, USA Disclosures: Yi-Hsiang Hsu, None

OSTEOPOROSIS EPIDEMIOLOGY: DIET AND ENVIRONMENTAL FACTORS SA0348

Chronic Exposure to Natural Uranium Affects Bone Cortical Parameters and Both Osteoblast and Osteoclast Gene Expression in Growing Rats Ndeye Marieme Wade-Gueye*1, Olivia Delissen2, Isabelle Dublineau3, Patrick Gourmelon 4, Maaˆmar Souidi3. 1IRSN, France, 2Institut de Radioprotection et de Suˆrete´ Nucle´aire (IRSN), DRPH, SRBE, LRTOX, Pierrelate, France, 3Institut de Radioprotection et de Suˆrete´ Nucle´aire (IRSN), DRPH, SRBE, LRTOX, Fontenay-auxRoses, France, 4Institut de Radioprotection et de Suˆrete´ Nucle´aire (IRSN), DRPH, Fontenay aux roses, France Disclosures: Ndeye Marieme Wade-Gueye, None

SA0349

Effects of Kale Supplementation on Bone Mineral Density and Bone Metabolic Markers in Postmenopausal Women Noriaki Yamamoto*. Niigata rehabilitation hospital, Japan Disclosures: Noriaki Yamamoto, None

95

Saturday

Osteoporosis: Still A Neglected Condition Among Elderly Individuals Living In Nursing Homes Ana Lirani-Galvao*1, Patricia Zach1, Adriana Silva1, Gilmar Teixeira1, Orivaldo Silva2, Marise Lazaretti Castro3. 1Universidade Federal de Sao Paulo, Brazil, 2Universidade de Sao Paulo, Brazil, 3Federal University of Sao Paulo, Brazil

SA0350

Socioeconomic Status Over the Lifecourse and Adult Bone Mineral Density: The Midlife in the U.S. Study Carolyn Crandall*1, Sharon Stein Merkin1, Neil Binkley2, Gail Greendale1, Teresa Seeman1, Arun Karlamangla 1. 1University of California, Los Angeles, USA, 2University of Wisconsin, USA Disclosures: Carolyn Crandall, None

OSTEOPOROSIS EPIDEMIOLOGY: FRACTURE OUTCOME SA0351

A Systematic Approach to Fragility Fracture Care and Prevention: Achieving a Consensus Paul Mitchell*1, Alastair McLellan2, Stephen Gallacher 3, Andrew Gallagher4, Eamonn Brankin5, Alun Cooper6, Graham Davenport7, James Cooper8, Anne Thurston8, Femi Adekunle9, Emma Gilbert10. 1University of Derby, United Kingdom, 2Western Infirmary, United Kingdom, 3Southern General Hospital, United Kingdom, 4Victoria Infirmary, United Kingdom, 5University of Glasgow, United Kingdom, 6Bridge Medical Centre, United Kingdom, 7Wrenbury Medical Centre, United Kingdom, 8National Osteoporosis Society, United Kingdom, 9Novartis Pharmaceuticals UK Ltd, United Kingdom, 10Amgen Limited, United Kingdom Disclosures: Paul Mitchell, Novartis Pharmaceuticals UK Ltd, 8; GlaxoSmithKline,5; Daiichi Sankyo UK Ltd, 5; Shire, 8; Amgen, 5; Novartis Pharmaceuticals UK Ltd, 5

SA0352

Accuracy of ICD-9 codes to identify Malunion and Nonunion & Developing an Algorithm to Improve Automated Case-Finding of Nonunion and Malunion Denise Boudreau* 1, Onchee Yu1, Leslie Spangler2, Thy Do 3, Monica Fujii1, Susan Ott4, Cathy Critchlow5, Delia Scholes6. 1Group Health Research Institute, USA, 2Group Health Cooperative, USA, 3Amgen Inc., USA, 4University of Washington, USA, 5Amgen, USA, 6 Group Health Cooperative Group Health Research Institute, USA Disclosures: Denise Boudreau, Amgen, 2

SA0353

Determination of Absolute Risk of Fracture Threshold for Intervention: A Decision Curve Analysis Nguyen Nguyen*1, Dana Bliuc 1, Steven Frost2, Jacqueline Center1, John Eisman1, Tuan Nguyen1. 1Garvan Institute of Medical Research, Australia, 2University of Western Sydney, Australia Disclosures: Nguyen Nguyen, None

SA0354

Epidemiologic Findings Shed Light Upon A Case Definition For Atypical Subtrochanteric and Femoral Shaft Femoral Fractures (STFSF) Adrianne Feldstein* 1, Dennis Black2, Nancy Perrin3, A. Gabriela Rosales 3, Darin Friess4, David Boardman5, Richard Dell6, Arthur Santora7, Julie Chandler7, Anne De Papp8, Mary Rix9, Eric Orwoll4. 1Kaiser Permanente Center for Health Research, USA, 2University of California, San Francisco, USA, 3Kaiser Permanente Northwest, Center for Health Research, USA, 4Oregon Health & Science University, USA, 5Kaiser Permanente NW, USA, 6Kaiser, USA, 7Merck Research Laboratories, USA, 8Merck & Co., Inc., USA, 9 Kaiser Permanente NW, Center for Health Research, USA Disclosures: Adrianne Feldstein, Amgen, 2; Merck, 2

SA0355

Incidence of and Predictors of False Negative Self-Reports of Hip Fractures in Cohort Studies: the Study of Osteoporotic Fractures (SOF) Beth Virnig1, Brent Taylor1, Kristine Ensrud2, Misti Paudel1, Sara Durham1, John Schousboe* 3. 1University of Minnesota, USA, 2Minneapolis VA Medical Center / University of Minnesota, USA, 3Park Nicollet Clinic, University of Minnesota, USA Disclosures: John Schousboe, None

SA0356

Medical Care Resource Utilization and Costs Associated with Teriparatide Therapy in U.S. Patients Russel Burge*1, T. Kim Le1, Yang Zhao1, Jeffrey Curtis2. 1Eli Lilly & Company, USA, 2 University of Alabama at Birmingham, USA Disclosures: Russel Burge, Eli Lilly & Company, 3

96

SA0357

Muscle Density, a Surrogate of Intermuscular Adiposity Derived from pQCT, Is an Independent Correlate of Fractures in Women Andy Kin On Wong*1, Aakash Bhargava1, Karen Beattie1, Christopher Gordon1, Laura Pickard1, Colin Webber2, Alexandra Papaioannou 2, Jonathan Adachi3. 1McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3St. Joseph’s Hospital, Canada Disclosures: Andy Kin On Wong, None

SA0358

Disclosures: Karol Estrada, None SA0359

Objective Assessment of Physical Activity and Risk of Non-spine Fractures: Osteoporotic Fractures in Men Study: (MrOS) Jane Cauley*1, Stephanie Harrison2, Dawn Mackey 3, Kristine Ensrud4, Eric Orwoll5, Peggy Cawthon6. 1University of Pittsburgh Graduate School of Public Health, USA, 2San Francisco Coordinating Center, USA, 3CPMC Research Institute, USA, 4Minneapolis VA Medical Center / University of Minnesota, USA, 5Oregon Health & Science University, USA, 6California Pacific Medical Center Research Institute, USA Disclosures: Jane Cauley, None

97

Saturday

Novel Genetic Factors and Biological Pathways Influencing BMD and Risk of Fracture Karol Estrada*1, Evangelis Evangelou 2, Yi-Hsiang Hsu3, Unnur Styrkarsdottir 4, Ching-Ti Liu5, Alireza Moayyeri 6, Stephen Kaptoge7, Emma Duncan8, Dave Evans9, Najaf Amin 10, Ling Oei 11, Ulrika Pettersson12, Terence O’Neill13, Jose Riancho14, Osten Ljunggren15, Francois Rousseau16, William Leslie 17, David Goltzman18, Barbara Obermayer 19, Bente Langdahl20, Xavier Nogue´s21, Richard Prince22, Paul Lips 23, Sulin Cheng24, Janja Marc25, George Dedoussis26, Panagoula Kollia 26, Maria Luisa Brandi27, Lynne Hocking28, Rita Khusainova29, Cyrus Cooper30, Rebecca Jackson31, Terho Lehtimaki 32, Jung-Min Koh 33, Claus Christiansen34, John Eisman35, Nelson Tang36, Daniel Chasman37, Vilmundur Gudnason38, Stella Trompet39, Paul M Ridker37, Douglas Kiel40, David Karasik40, Omar Albagha41, Matthew Brown42, Tim Spector43, M Zillikens44, Claes Ohlsson45, Gudmar Thorleifsson4, Jonathan Reeve46, Liesbeth Vandenput47, Ryan Minster48, Candace Kammerer 49, Laura Yerges-Armstrong50, Brent Richards51, Jane Cauley49, Annie Kung52, Daniel Koller53, John Ioannidis2, Stuart Ralston41, Andre Uitterlinden 54, Fernando Rivadeneira 1, for the AOGC, GENOMOS and GEFOS consortia55. 1Erasmus University Medical Center, The Netherlands, 2University of Ioannina School of Medicine, Greece, 3 Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 4 Decode Genetics, Iceland, 5Boston University School of Public Health, USA, 6University of Cambridge, United Kingdom, 7University of Cambridge Bone Research Group, United Kingdom, 8Royal Brisbane & Women’s Hospital, Australia, 9University of Bristol, United Kingdom, 10Erasmus University Medical Center, Netherlands, 11Erasmus University Medical Center, The Netherlands, 12Umea University, Sweden, 13Manchester University, United Kingdom, 14University of Cantabria, Spain, 15Uppsala University Hospital, Sweden, 16Universite´ Laval & CHUQ, Canada, 17University of Manitoba, Canada, 18 McGill University Health Centre, Canada, 19Medical University, Austria, 20Aarhus Sygehus, Aarhus University Hospital, Denmark, 21Autonomous University of Barcelona, Spain, 22Sir Charles Gairdner Hospital, Australia, 23VU University Medical Center, The Netherlands, 24University of Jyva¨skyla¨, Finland, 25University of Ljubljana, Slovenia, 26 University of Athens, Greece, 27University of Florence, Italy, 28University of Aberdeen, United Kingdom, 29Institute of Biochemistry & Genetics USC RAS, Russia, 30University of Southampton, United Kingdom, 31The Ohio State University, USA, 32Tampere University Hospital, Finland, 33Asan Medical Center, South Korea, 34CCBR, Center for Clinical & Basic Research, Denmark, 35Garvan Institute of Medical Research, Australia, 36The Chinese University of Hong Kong, China, 37Brigham & Women’s Hospital, USA, 38 Icelandic Heart Association Research Institute, Iceland, 39Leiden University Medical Center, Netherlands, 40Hebrew SeniorLife, USA, 41University of Edinburgh, United Kingdom, 42Diamantina Institute of Cancer, Immunology & Metabolic Medicine, Australia, 43King’s College London, United Kingdom, 44Erasmus MC Rotterdam, The Netherlands, 45Centre for Bone & Arthritis Research, Sweden, 46Addenbrookes Hospital, United Kingdom, 47University of Gothenburg, Sweden, 48University of Pittsburgh, USA, 49 University of Pittsburgh Graduate School of Public Health, USA, 50University of Maryland, USA, 51McGill University, Canada, 52Dr. Kung-Wai Chee Clinic, Hong Kong, 53 Indiana University School of Medicine, USA, 54Rm Ee 575, Genetic Laboratory, The Netherlands, 55USA

SA0360

The Incidence of Femur Fractures Below Trochanter Increases Exponentially with Age Lisa Strahm* 1, Albrecht Popp 1, Patrick Schwab2, Christoph Senn1, Romain Perrelet1, Kurt Lippuner1. 1Osteoporosis Policlinic, University of Bern, Switzerland, 2Swiss Federal Statistical Office, Switzerland Disclosures: Lisa Strahm, None

SA0361

The Profile of Diseases Had Previous Fractures of the Femur By Failing Into a Group of 40 Elderly Patients at the Hospital Public, Sao Paulo, Brazil Roberto Queiroz1, Ursula Karsch1, Bianca Segantin1, Fabiana Fonseca*2, Thais Braga1, Ana Elisa Rosa1, Manuela Santos1. 1PUC - SP, Brazil, 2PUC Sp, Brazil Disclosures: Fabiana Fonseca, None

SA0362

Trends in Hip Fracture Rates in Canada: An Age-Period-Cohort Analysis Sonia Jean*1, Siobhan O’Donnell 2, Claudia Lagace´2, Peter Walsh2, Christina Bancej2, ´ Suzanne Morin3, Jacques Brown4, William Leslie 5. 1INSTITUT NATIONAL DE SANTE ´ BEC, Canada, 2Public Health Agency of Canada, Canada, 3McGill PUBLIQUE DU QUE University Health Centre, Canada, 4Laval University, Canada, 5University of Manitoba, Canada Disclosures: Sonia Jean, None

OSTEOPOROSIS EPIDEMIOLOGY: GENETIC STUDIES SA0363

CIITA Polymorphisms Affecting Expression of MHCII are Associated to BMD, Bone Loss and Fracture Maria Swanberg*1, Fiona McGuigan2, Mattias Callreus1, Paul Gerdhem 3, Kristina Akesson4. 1Lund University, Sweden, 2University of Lund, Malmo¨, Skane University Hospital, Malmo¨, Sweden, 3Karolinska Institutet, Sweden, 4Ska˚ne University Hospital, Malmo¨, Sweden Disclosures: Maria Swanberg, None

SA0364

Bivariate Linkage Analysis Identifies a Genomic Region with Potential Pleiotropic Effects on Bone Mineral Density and Subclinical Cardiovascular Disease Indices Allison Kuipers*1, Candace Kammerer 1, Iva Miljkovic2, Clareann H. Bunker2, Alan L. Patrick3, Victor W. Wheeler3, Kim Sutton-Tyrrell 2, Joseph Zmuda1. 1University of Pittsburgh Graduate School of Public Health, USA, 2University of Pittsburgh, USA, 3 Tobago Health Studies Office, Trinidad & tobago Disclosures: Allison Kuipers, None

SA0365

Heritability of Prevalent Vertebral Fracture and Vertebral Volumetric Bone Mineral Density in Three Generations of the Framingham Heart Study Ching-Ti Liu*1, Yanhua Zhou2, Mary Bouxsein3, Harry Genant4, Yi-Hsiang Hsu5, Kerry Broe6, Thomas Lang7, Serkalem Demissie1, David Karasik8, Adrienne Cupples1, Douglas Kiel8. 1Boston University School of Public Health, USA, 2Boston University, USA, 3Beth Israel Deaconess Medical Center, USA, 4UCSF/Synarc, USA, 5Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 6Hebrew Senior Life, USA, 7 University of California, San Francisco, USA, 8Hebrew SeniorLife, USA Disclosures: Ching-Ti Liu, None

SA0366

Interaction of Genome Wide Variants with Dietary Vitamin D Intake on Serum Vitamin D Concentration: The Framingham Osteoporosis Study Yue Fang*1, Ching-Ti Liu2, Yi-Hsiang Hsu3, Adrienne Cupples4, David Karasik5, Douglas Kiel5. 1Hebrew Seniorlife Center at Harvard Medical School, USA, 2Boston University School of Public Health, USA, 3Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 4Department of Biostatistics, Boston University School of Public Health, USA, 5Hebrew SeniorLife, USA Disclosures: Yue Fang, None

98

SA0367

Meta-analysis of Genome-wide Association Studies in Premenopausal White Women Identifies Variants in WNT16, ESR1, and Novel BMD Loci Daniel Koller*1, David Karasik2, Hou-Feng Zheng3, Laura Yerges-Armstrong4, Ching-Ti Liu5, Dongbing Lai1, Karol Estrada6, Fernando Rivadeneira6, Andre Uitterlinden 7, Sylvie Giroux8, Francois Rousseau9, Stefan Czerwinski10, Bradford Towne10, Michael Econs1, Braxton Mitchell11, Brent Richards3, Douglas Kiel2, Tatiana Foroud1. 1Indiana University School of Medicine, USA, 2Hebrew SeniorLife, USA, 3McGill University, Canada, 4 University of Maryland, USA, 5Boston University School of Public Health, USA, 6 Erasmus University Medical Center, The Netherlands, 7Rm Ee 575, Genetic Laboratory, The Netherlands, 8Centre de recherche CHUQ-SFA, Canada, 9University Laval, Canada, 10 Wright State University Boonshoft School of Medicine, USA, 11University of Maryland, Baltimore, USA Disclosures: Daniel Koller, None

OSTEOPOROSIS EPIDEMIOLOGY: LIFESTYLE AND BONE (ALCOHOL, TOBACCO) SA0368

Women With Inadequately Controlled Type 2 Diabetes Are At Increased Risk of Osteoporotic Fractures Despite Higher Bone Mineral Density: The Rotterdam Study Ling Oei*1, Martha Castano-Betancourt2, Huibert Pols 3, Abbas Dehghan4, Andre Uitterlinden 5, Fernando Rivadeneira3, M Zillikens6. 1Erasmus University Medical Center, The Netherlands, 2Erasmus MC, The Netherlands, 3Erasmus University Medical Center, The Netherlands, 4Erasmus MC, Netherlands, 5Rm Ee 575, Genetic Laboratory, The Netherlands, 6Erasmus MC Rotterdam, The Netherlands Disclosures: Ling Oei, None

OSTEOPOROSIS EPIDEMIOLOGY: MENOPAUSE AND GONADAL STEROIDS BMD and Breast Cancer Risk: A Positive Association in Women >50 Years and a Negative in Women ,50 Years? The HUNT Study, Norway Siri Forsmo* 1, Kathinka Slørdahl 2, Arnulf Langhammer3. 1Norwegian University of Science & Technology, Norway, 2Faculty of Medicine, Norwegian University of Science & Technology, Norway, 3Dept. of Public Health & General Practice, Norwegian University of Acience & Technology, Norway Disclosures: Siri Forsmo, None SA0370

Menopausal, but not Ethnic or Seasonal Differences in Serum C-telopeptide in UK Caucasian and South Asian Women Andrea Darling* 1, Fatma Gossiel 2, Rosemary Hannon2, Richard Eastell2, Susan LanhamNew1. 1University of Surrey, United Kingdom, 2University of Sheffield, United Kingdom Disclosures: Andrea Darling, None

OSTEOPOROSIS EPIDEMIOLOGY: RISK FACTORS SA0371

A Study of the Risk Factors and Prevalence af Osteoporosis in Guayaquil, Ecuador. Augusto Focil*. California Hispanic Osteoporosis Foundation (CHOF), USA Disclosures: Augusto Focil, None

SA0372

Analysis of Clinical Risk Factors for Post-menopausal Osteoporosis Based on WHO Fracture Risk Assessment (FRAX) Tool Sudhir Unni 1, Yiwen Yao1, Karen Gunning1, Jeffrey Curtis2, Joanne LaFleur*1. 1 University of Utah, USA, 2University of Alabama at Birmingham, USA Disclosures: Joanne LaFleur, Novartis, 2

SA0373

Anticonvulsant and Opioid Use and Fractures in Veterans with Spinal Cord Injury Laura Carbone*1, Amy Chin2, Todd Lee2, Stephen Burns3, Jelena Svircev4, Helen Hoenig5, Titilola Akhigbe1, Frances Weaver2. 1University of Tennessee Health Science Center, USA, 2 Edward J. Hines, Jr. VA Hospital, USA, 3VA Puget Sound Healthcare System, USA, 4VA Puget Sound, USA, 5VA Medical Center, USA Disclosures: Laura Carbone, None

99

Saturday

SA0369

SA0374

Elevated Coronary Artery Calcium Scores Might be Related to Low Bone Mineral Density in Korean Women Beom-hee Choi*, Kyu-nam Kim, Sang hyeon Je, Sang-man Kim, Nam-seok joo, Duck-Joo Lee, Kwang-min Kim. Family Medicine, South Korea Disclosures: Beom-hee Choi, None

SA0375

Fat Mass and Fracture Risk in Elderly Men and Women: A Prospective Study Shuman Yang* 1, Nguyen Nguyen2, Jacqueline Center2, John Eisman2, Tuan Nguyen2. 1 Garvan Institute, Australia, 2Garvan Institute of Medical Research, Australia Disclosures: Shuman Yang, None

SA0376

Fat Mass Is Negatively Associated with Bone Mineral Content in Korean Jung Hee Kim*1, Hyung Jin Choi2, Min Joo Kim2, Jee Hyun An2, Sang Wan Kim3, Seong Yeon Kim1, Nam H. Cho4, Chan Soo Shin2. 1Seoul National University College of Medicine, South Korea, 2Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 3Seoul National University Boramae Hospital, South Korea, 4Ajou University School of Medicine, South Korea Disclosures: Jung Hee Kim, None

SA0377

Fracture Incidence in Obese Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women Juliet Compston*1, Nelson Watts2, Roland Chapurlat3, Cyrus Cooper4, Steven Boonen5, Susan Greenspan6, Johannes Pfeilschifter7, Stuart Silverman8, Adolfo Diez-Perez9, Robert Lindsay10, Kenneth Saag 11, Coen Netelenbos 12, Stephen Gelhbach13, Frederick Hooven14, Julie Flahive13, Jonathan Adachi15, Maurizio Rossini16, Andrea Lacroix17, Christian Roux18, Philip Sambrook19, Ethel Siris 20. 1University of Cambridge School of Clinical Medicine, United Kingdom, 2University of Cincinnati Bone Health & Osteoporosis Center, USA, 3E. Herriot Hospital, France, 4University of Southampton, United Kingdom, 5Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 6University of Pittsburgh, USA, 7Alfried Krupp Krankenhaus Steele, Germany, 8Cedars-Sinai/UCLA, USA, 9Autonomous University of Barcelona, Spain, 10Helen Hayes Hospital, USA, 11 University of Alabama at Birmingham, USA, 12VU Medical Center, The Netherlands, 13 UMass Medical School, USA, 14University of Massachusetts Medical School, USA, 15St. Joseph’s Hospital, Canada, 16University of Verona, Italy, 17Fred Hutchinson Cancer Research Center, USA, 18Hospital Cochin, France, 19Royal North Shore Hospital, Australia, 20Columbia University College of Physicians & Surgeons, USA Disclosures: Juliet Compston, None

SA0378

High Serum Adiponectin Predicts Incident Fractures in Elderly Men. Mr OS Sweden Helena Johansson* 1, Anders Ode´n 2, Ulf Lerner3, Hans Jutberger4, Mattias Lorentzon5, Elizabeth Barrett-Connor6, Magnus Karlsson7, Osten Ljunggren8, Ulf Smith 9, Eugene McCloskey 10, John Kanis 11, Claes Ohlsson12, Dan Mellstrom13. 1Swe, 2Centre for Bone & Arthritis Research (CBAR), Sahlgrenska Academy, University of Gothenburg, Sweden, Sweden, 3University of Umea, Sweden, 4University Hospital Sahlgrenska, Sweden, 5Center for Bone Research at the Sahlgrenska Academy, Sweden, 6University of California, San Diego, USA, 7Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 8Uppsala University Hospital, Sweden, 9Lundberg Laboratory for Diabetes Research, University of Gothenburg, Sweden, 10University of Sheffield, United Kingdom, 11University of Sheffield, Belgium, 12Centre for Bone & Arthritis Research, Sweden, 13Sahlgrenska University Hospital, Sweden Disclosures: Helena Johansson, None

SA0379

Inverse Associations between Abdominal Visceral Adipose Tissue and Bone Density Miryoung Lee*1, Audrey Choh1, Keith Wurzbacher1, Ellen Demerath2, Richard Sherwood 3, Dana Duren4, Roger Siervogel1, Bradford Towne1, Stefan Czerwinski 1. 1 Wright State University Boonshoft School of Medicine, USA, 2University of Minnesota School of Public Health Division of Epidemiology & Community Health, USA, 3Lifespan Health Research Center, Wright State University, USA, 4Wright State University, USA Disclosures: Miryoung Lee, None

100

SA0380

New Loop Diuretic Prescriptions Increase the Acute Risk of Hip Fracture Sarah Berry*1, Yanyan Zhu2, Hyon Choi2, Douglas Kiel3, Yuqing Zhang2. 1Hebrew SeniorLife/Beth Israel Deaconess Medical Center, USA, 2Boston University School of Medicine, USA, 3Hebrew SeniorLife, USA Disclosures: Sarah Berry, None

SA0381

Prevalence of Higher Fracture Risk Using FRAXH in Community-Dwelling Japanese People Yasuyo Abe*1, Eugene McCloskey2, Makoto Osaki1, Kiyoshi Aoyagi1. 1Nagasaki University, Japan, 2University of Sheffield, United Kingdom Disclosures: Yasuyo Abe, None

SA0382

PTH Is a Predictor of Osteporotic Fracture in older individuals: the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study Vilmundur Gudnason*1, KRISTIN SIGGEIRSDOTTIR1, Thor Aspelund2, Brynjolfur Jonsson3, Gunnar Sigurdsson4, Tamara Harris5. 1Icelandic Heart Association Research Institute, Iceland, 2Icelandic Heart Association, Iceland, 3Malmo University Hospital, Sweden, 4Landspitali, Iceland, 5Intramural Research Program, National Institute on Aging, USA Disclosures: Vilmundur Gudnason, None

SA0383

QCT vBMD and Vascular and Valvular Calcification: The Framingham Study Elizabeth Samelson*1, Christopher O’Donnell2, Kerry Broe3, Udo Hoffmann4, Sekar Kathiresan2, Serkalem Demissie5, L. Adrienne Cupples5, Mary Bouxsein 6, Douglas Kiel7. 1 Hebrew SeniorLife, Harvard Medical School, USA, 2National Heart, Lung & Blood Institute’s Framingham Heart Study, USA, 3Hebrew Senior Life, USA, 4Massachusetts General Hospital, USA, 5Department of Biostatistics, Boston University School of Public Health, USA, 6Beth Israel Deaconess Medical Center, USA, 7Hebrew SeniorLife, USA Disclosures: Elizabeth Samelson, None

Temporal Trends in 25-Hydroxyvitamin D levels and parathyroid hormone in a populationbased study Claudie Berger*1, Linda Greene-Finestone2, Lisa Langsetmo3, Lawrence Joseph1, Nancy Kreiger4, Brent Richards1, Christopher Kovacs5, Kurtis Sarafin6, K. Shawn Davison7, Jonathan Adachi8, Jacques Brown7, David Hanley9, David Goltzman10. 1McGill University, Canada, 2Public Health Agency of Canada, Canada, 3Canandian Multicenter Osteoporosis Study, Canada, 4University of Toronto, Canada, 5Memorial University of Newfoundland, Canada, 6Health Canada, Canada, 7Laval University, Canada, 8St. Joseph’s Hospital, Canada, 9University of Calgary, Canada, 10McGill University Health Centre, Canada Disclosures: Claudie Berger, None

SA0385

The Association Between Fracture and Obesity Is Site-Depending: A Population-Based Study Daniel Prieto-alhambra*1, Francesc Fina Aviles2, Eduard Hermosilla3, Daniel MartinezLaguna4, Cristina Carbonell5, Robert Gu¨erri 6, Xavier Nogues6, Adolfo Diez-Perez6. 1 Institut Municipal D’Investigacio´ Me`dica, Spain, 2SIDIAP Database, IDIAP Jordi Gol i Gurina; Barcelona Primary Care Dept, Institut Catala de la Salut, Spain, 3SIDIAP Database, IDIAP Jordi Gol i Gurina, Spain, 4Barcelona Primary Health Care Department, Institut Catala` de la Salut, Spain, 5Healthy Primary Care Via Roma Barcelona.Facultat de Medicina Universitat de Barcelona, Spain, 6Department of Internal Medicine, URFOA IMIM-Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona, RETICEF (Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain, Spain Disclosures: Daniel Prieto-alhambra, None

101

Saturday

SA0384

SA0386

The Association Between S-25-Hydroxyvitamin D and Total Femur BMD May Depend on Serum Concentrations of Retinol in Men. The Hordaland Health Study and The Oslo Health Study. Norwegian Epidemiologic Osteoporosis Studies (NOREPOS) Kristin Holvik*1, Haakon E. Meyer2, Glara G. Gjesdal3, Rune Blomhoff4, Grethe S. Tell1. 1 Department of Public Health & Primary Health Care, University of Bergen, Norway, 2 Department of Community Medicine, Institute of Health & Society, University of Oslo, & Division of Epidemiology, Norwegian Institute of Public Health, Norway, 3Department of Rheumatology, Haukeland University Hospital, & Institute of Medicine, University of Bergen, Norway, 4Department of Nutrition, Institute of Basic Medical Sciences, Medical Faculty, University of Oslo, Norway Disclosures: Kristin Holvik, None

SA0387

The Effect of Clinical Risk Factors (CRF) on Fracture Risk Decreases with Age Diantha Howard, Edward Leib, Lynda Tilluckdharry*. University of Vermont, USA Disclosures: Lynda Tilluckdharry, None

SA0388

The Relationship of Bone Marrow Fat with Bone Geometry and Strength Differs By Diabetic Status Yahtyng Sheu*1, Francesca Amati2, Ann Schwartz3, Xiaojuan Li 3, Christine Lee 4, Christopher Gordon5, Bret Goodpaster6, Robert Boudreau6, Joseph Zmuda1, Eric Orwoll7, Jane Cauley1. 1University of Pittsburgh Graduate School of Public Health, USA, 2 University of Lausanne, Switzerland, 3University of California, San Francisco, USA, 4 OHSU, USA, 5McMaster University, Canada, 6University of Pittsburgh, USA, 7Oregon Health & Science University, USA Disclosures: Yahtyng Sheu, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE MINERAL DENSITY SA0389

Longitudinal Population-based Study Assessing Abdominal Aortic Calcification and Volumetric BMD in Postmenopausal Women Louise Stuart*1, Elizabeth Atkinson1, Jon Camp1, Shreyasee Amin1, Sundeep Khosla2, Ann Kearns1. 1Mayo Clinic, USA, 2College of Medicine, Mayo Clinic, USA Disclosures: Louise Stuart, None

SA0390

The Serum Uric Acid Is Not Associated with Osteoporosis in Postmenopausal Women Hee-Jeong Choi*1, Byung-Yeon Yu2, Han Jin Oh3, ILWOO JOO4. 1Department of Family Medicine, Eulji University School of Medicine, South Korea, 2Department of Family Medicine, Konyang University School of Medicine, South Korea, 3Kwandong University, College of Medicine, South Korea, 4Cheil General Hospital, Kwandong University, South Korea Disclosures: Hee-Jeong Choi, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE REMODELING SA0391

Blockade of Endogenous Gi Signaling in Osteoblasts Stimulates Bone Formation and Prevents Age-Related Bone Loss Liping Wang*1, Susan M. Millard2, Dylan O’Carroll1, Lalita Wattanachanya3, Richard Kao4, Wei-Dar Lu 1, Aaron J. Fields 5, Jeffrey C. Lotz5, Robert Nissenson3. 1VA Medical Center, San Francisco, USA, 2University of Queensland, Australia, 3VA Medical Center & University of California, San Francisco, USA, 4UCSF/VAMC, USA, 5Department of Orthopaedic Surgery, UCSF, USA Disclosures: Liping Wang, None

SA0392

Chronic Central Administration of Ghrelin Increases Bone Mass Through Mechanisms Independent of Appetite Regulation Hyung Jin Choi*1, Kyoung Ho Ki 1, Jae-Yeon Yang1, Bo Young Jang1, Jung Ah Song1, Wook-Young Baek2, Jung Hee Kim3, Jee Hyun An1, Sang Wan Kim4, Seong Yeon Kim1, Jung-Eun Kim5, Chan Soo Shin1. 1Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 2Department of Molecular Medicine, Cell & Matrix Research Institute, Kyungpook National University School of Medicine, South Korea, 3Seoul National University College of Medicine, South Korea, 4Seoul National University Boramae Hospital, South Korea, 5Kyungpook National University School of Medicine, South Korea Disclosures: Hyung Jin Choi, None

102

SA0393

Circulating Sclerostin Correlates to Bone Mineral Mass, Micro-Structure and Turnover in Healthy Elderly Men and Women Claire Durosier* 1, Antoon Van Lierop2, Serge Ferrari3, Thierry Chevalley4, Socrates Papapoulos 2, Rene Rizzoli 5. 1Hopitaux Universitaires De Geneve, Switzerland, 2Leiden University Medical Center, The Netherlands, 3Geneva University Hospital & Faculty of Medicine, Switzerland, 4University Hospitals of Geneva Division of Bone Diseases, Switzerland, 5University Hospital, Switzerland Disclosures: Claire Durosier, None

SA0394

Circulating Sclerostin Levels and Bone Turnover in Type 1 and 2 Diabetes Ranuccio Nuti*1, Roberto Valenti2, Daniela Merlotti1, Elena Ceccarelli3, Martina Ruvio3, Maria Giulia Pietrini3, Cosimo Capodarca 3, Maria Beatrice Franci3, Anna Calabro`3, Konstantinos Stolakis3, Francesco Dotta3, Luigi Gennari1. 1University of Siena, Italy, 2S. Maria Alle Scotte Hospital, Italy, 3Dept. Internal Medicine Endocrine Metabolic Sciences & Biochemistry University of Siena, Italy Disclosures: Ranuccio Nuti, None

SA0395

Long-term Treatment with Raloxifene, but not Bisphosphonates, Reduces Circulating Sclerostin Levels in Postmenopausal Women Hong-Hee Kim1, Yun Ey Chung2, Sun-Kyeong Lee3, Sun-Young Lee4, Seung Hun Lee*5, Ghi Su Kim5, Shin-Yoon Kim6, Faryal S. Mirza3, Jung-Min Koh 7, Joseph A. Lorenzo3. 1 Seoul National University, South Korea, 2Department of Internal Medicine, Seoul Veterans Hospital, South Korea, 3Division of Endocrinology, University of Connecticut Health Center, USA, 4Asan Institute for Life Sciences, South Korea, 5Asan Medical Center, University of Ulsan College of Medicine, South Korea, 6Kyungpook National University Hospital, South Korea, 7Asan Medical Center, South Korea Disclosures: Seung Hun Lee, None

Bone Microarchitecture Assessment in Postmenopausal Women with Atypical Fractures of the Femur and Long Term Bisphosphonate Therapy Maria Belen Zanchetta* 1, Ana Galich2, mirena buttazzoni3, maria diehl 3, Candela Fernandez 4, fernando silveira3, Fabio Massari1, Cesar Bogado1, Jose Ruben Zanchetta1. 1 Instituto de Investigaciones Metabolicas (IDIM), Argentina, 2Instituto De Investigaciones Metabolicas, Argentina, 3md, Argentina, 4Hospital De Clinicas - Universidad De Buenos Aires, Argentina Disclosures: Maria Belen Zanchetta, None

SA0397

Histomorphometric Evaluation of Transiliac Bone Biopsies after Bariatric Surgery. Noortje Rabelink* 1, Nathalie Bravenboer 2, Dave Schweitzer3, Coen Netelenbos4, Paul Lips2. 1VU University Medical Center, Netherlands, 2VU University Medical Center, The Netherlands, 3Reinier de Graaf Gasthuis, Netherlands, 4VU Medical Center, The Netherlands Disclosures: Noortje Rabelink, None

OSTEOPOROSIS PATHOPHYSIOLOGY: DIETARY FACTORS SA0398

Erythrocyte Fatty Acid Composition of Postmenopausal Women with and without Osteoporosis: Case-Control Study in Korea Hyoun-Jung Moon1, Yongsoon Park1, Hae-Hyeog Lee 2, Kyo Il Suh3, Jin-Yong Yoo3, HyeongKyu Park3, Tae-Hee Kim 2, Dongwon Byun*4, Myung Hi Yoo3. 1Hanyang University, South Korea, 2Soon Chun Hyang University Bucheon Hospital, South Korea, 3 Soon Chun Hyang University Hospital, South Korea, 4Soon Chun Hyang University Hospital, South Korea Disclosures: Dongwon Byun, None

SA0399

Implications of Compromised Zinc Status on Bone Loss Associated with Low Grade Chronic Inflammation in C57BL/6 Mice Elizabeth Rendina*, Yan Wang, Kelsey Hembree, MCKALE Davis, Barbara Stoecker, Stephen Clarke, Edralin Lucas, Brenda Smith. Oklahoma State University, USA Disclosures: Elizabeth Rendina, None

103

Saturday

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE STRUCTURE SA0396

SA0400

Rosiglitazone Decreased Muscle Cross-sectional Area and Increased %Fat While Maintaining Glycemic Control in Women with Type 2 Diabetes (T2D) Timothy Streeper*1, Isra Saeed1, Thomas Lang1, John Kornak1, Chengshi Jin1, Allison R. Northcutt 2, Barbara Kravitz2, Gitanjali Paul 2, Alexander R. Cobitz2, Lorraine Fitzpatrick3, Antonio J. Nino 2. 1UC San Francisco, USA, 2GlaxoSmithKline Pharmaceuticals, USA, 3GlaxoSmithKline, USA Disclosures: Timothy Streeper, GlaxoSmithKline Pharmaceuticals, 2

SA0401

b-Cryptoxanthin, A Citrus Xanthophyl Carotenoid Prevents Inflammatory Bone Loss of Alveolar Bone in the Model for Periodontal Disease Michiko Hirata*, Chiho Matsumoto, Tsukasa Tominari, Masaki Inada, Chisato Miyaura. Tokyo University of Agriculture & Technology, Japan Disclosures: Michiko Hirata, None

OSTEOPOROSIS PATHOPHYSIOLOGY: MALE OSTEOPOROSIS SA0402

Bone Steatosis And Osteocyte Apoptosis In Alcohol-induced Bone Loss Delphine Maurel*1, Stephane Pallu2, Christelle Jaffre3, Nathalie Boisseau4, Nick Fazzalari5, Rustem Uzbekov6, Gael Rochefort7, Claude-Laurent Benhamou8. 1Inserm Unit 658, Hopital Porte Madeleine, Orle´ans, France, France, 2INSERM U 658 / University of Orle´ans, France, 3INSERM Unit U658, France, 4Laboratory of Physical Activity Biology, Blaise Pascal University, France, 5Institute of Medical & Veterinary Science, Australia, 6 Microscopy Department, Medical Faculty, Tours University, France, 7INSERM U658, France, 8INSERM Unit U658, CHR Orleans, France Disclosures: Delphine Maurel, None

SA0403

Fractures Are Associated with Cortical Porosity at the Tibia: A Case-Control Study of MicroArchitectural Bone Parameters in Men with Idiopathic Osteoporosis Agnes Ostertag1, Martine Cohen-Solal2, Sylvie Fernandez 3, Eric Vicaut4, Marie-Christine De Vernejoul*5. 1U606 INSERM, France, 2Centre Viggo Petersen, France, 3Hoˆpital Lariboisie`re, France, 4Unite´ de Recherche Clinique Lariboisie`re-St Louis Hoˆpital Fernand Widal, France, 5Fe´de´ration De Rhumatologie Et INSERM U606, France Disclosures: Marie-Christine De Vernejoul, None

OSTEOPOROSIS PATHOPHYSIOLOGY: MISCELLANEOUS SA0404

A Comparative Randomized Trial of Levetiracetam and Older Antepileptic Drugs: Bone Health and Related Outcomes Tahir Hakami1, Terence O’Brien1, Sandra Petty2, Jemma Christie1, Susan Kantor 1, Marian Todaro3, John Wark*3. 1University of Melbourne, Australia, 2The University of Melbourne, Australia, 3Royal Melbourne Hospital, Australia Disclosures: John Wark, None

SA0405

Anti-Retroviral Therapy Drives Bone Loss in AIDS Patients as a Consequence of Immune Reconstitution Ighovwerha Ofotokun1, Tatyana Vikulina1, Ashwini Vunnava1, Susanne Roser-Page1, Masayoshi Yamaguchi1, Francois Villinger1, Kenneth Rogers1, Majd Zayzafoon 2, Anandi Sheth1, Jeffrey Lennox1, M. Neale Weitzmann*1. 1Emory University School of Medicine, USA, 2University of Alabama at Birmingham, USA Disclosures: M. Neale Weitzmann, None

SA0406

Aromatase Inhibitor Significantly Increased Circulating Sclerostin Level in Patients with Endocrine-responsive Breast Cancer Yumie Rhee*1, Yoon Jung Chung2, Se Hwa Kim3, Sung-Kil Lim1, Byeong Woo Park4. 1 Department of Internal Medicine, College of Medicine, Yonsei University, South Korea, 2 Brain Korea 21 Project for Medical Science, Yonsei University, South Korea, 3Kwandong University College of Medicine, Myongji Hospital, South Korea, 4Department of Surgery, College of Medicine, Yonsei University, South Korea Disclosures: Yumie Rhee, None

104

SA0407

Circulating Levels of Sclerostin Are Increased In Patients With Type 2 Diabetes Mellitus Antonia Garcı´a-Martı´n*1, Pedro Rozas-Moreno 2, Sonia Morales-Santana3, Beatriz Garcı´a-Fontana3, Jose´ Antonio Garcı´a-Salcedo4, Rebeca Reyes5, Manuel Munoz-Torres6. 1 Bone Metabolic Unit. Endocrinology Division., Spain, 2Endocrinology Division. Hospital General de Ciudad Real. Ciudad Real, Spain., Spain, 3Proteomic Research Service. Hospital Universitario San Cecilio., Spain, 4Bone Metabolic Unit (RETICEF). Endocrinology Division. Hospital Universitario San Cecilio., Spain, 5Bone Metabolic Unit., Spain, 6University Hospital, Spain Disclosures: Antonia Garcı´a-Martı´n, None

SA0408

Loss of Caspase-2 Alters Skeletal Stem Cell Properties and Results in Osteoporosis In Old C57BL/6 Mice Ramaswamy Sharma*1, Difernando Vanegas 2, Danielle Victor2, Kathleen Woodruff2, Marisa Lopez-Cruzan2, Roberto Fajardo3, Stephen Harris4, Sherry Abboud Werner 4, Brian Herman2. 1University of Texas Health Sciences Center At San Antonio, USA, 2 University of Texas HSC at San Antonio, USA, 3UT Health Science Center, San Antonio, USA, 4University of Texas Health Science Center at San Antonio, USA Disclosures: Ramaswamy Sharma, None

SA0409

RANKL Production by B Lymphocytes Contributes to the Bone Loss Induced by Inflammation and Ovariectomy Melda Onal*, Jinhu Xiong, Priscilla Cazer, Stavros Manolagas, Charles O’Brien. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Melda Onal, None

SA0410

Disclosures: Dan Jia, None SA0411

2011 ASBMR SHUN-ICHI HARADA YOUNG INVESTIGATOR AWARD Sclerostin and Risk of Hip Fracture in Older Women Aarthi Arasu*1, Peggy Cawthon2, Thy Do3, Puneet Arora4, Li-Yung Lui2, Jane Cauley5, Kristine Ensrud6, Steven Cummings 7. 1University of California, San Francisco, USA, 2 California Pacific Medical Center Research Institute, USA, 3Amgen, Inc., USA, 4Amgen, USA, 5University of Pittsburgh Graduate School of Public Health, USA, 6Minneapolis VA Medical Center / University of Minnesota, USA, 7San Francisco Coordinating Center, USA Disclosures: Aarthi Arasu, Amgen, 5

OSTEOPOROSIS TREATMENT (CLINICAL): ANABOLIC AGENTS SA0412

Changes in Bone Turnover Markers After Weekly Teriparatide Administration in Postmenopausal Women with Osteoporosis Toshitsugu Sugimoto*1, Toshitaka Nakamura2, Hideki Yoshikawa3, Masataka Shiraki4. 1 Shimane University School of Medicine, Japan, 2University of Occupational & Environmental Health, Japan, 3Osaka University Graduate School of Medicine, Japan, 4 Research Institute & Practice for Involutional Diseases, Japan Disclosures: Toshitsugu Sugimoto, Daiichi Sankyo Co., 5; Asahi-Kasei Pharma Co., 5

SA0413

Comparative Effects of Teriparatide and Risedronate in Glucocorticoid-Induced Osteoporosis in Men: 18-Month Results of the EuroGIOPS Trial. Claus-C Glu¨er*1, Fernando Marin2, Christian Graeff1, Jaime Pen˜a 3, Andreas Reisinger4, Helmut Petto5, Philippe Zysset4. 1Biomedical Imaging, Department of Diagnostic Radiology, UKSH, Germany, 2Lilly Research Center, United Kingdom, 3Biomedical Imaging. Department of Diagnostic Radiology, UKSH, Germany, 4Institute for Lightweight Design & Structural Biomechanics, Vienna University of Technology, Austria, 5 Lilly Research Center, Austria Disclosures: Claus-C Glu¨er, None

105

Saturday

Rapid Loss of Bone Mass and Strength after Non-bone Focal X-ray Irradiation in Growing Mice Peter Corry, Dan Jia*. University of Arkansas for Medical Sciences, USA

SA0414

Effects of Teriparatide on Cortical Histomorphometric Variables in Patients Receiving Longterm Alendronate Therapy Jan Stepan*1, Harald Dobnig2, Astrid Fahrleitner-Pammer3, Yanfei Ma4, Qing Zeng4, Xiaohai Wan5, Fernando Marin6, Imre Pavo7. 1Charles University, Czech Republic, 2 Department of Internal Medicine, Division of Endocrinology & Metabolism, Medical University of Graz, Austria, 3Medical University Graz, Austria, 4Eli Lilly & Company, USA, 5Lilly USA, LLC, USA, 6Eli Lilly & Company, Spain, 7Eli Lilly & Company, Austria Disclosures: Jan Stepan, None

SA0415

In Premenopausal Women with Idiopathic Osteoporosis, Baseline Bone Turnover Predicts Response to Teriparatide Adi Cohen*1, Emily Stein2, David Dempster 3, Hua Zhou4, Robert Recker5, Joan Lappe5, Chiyuan Zhang3, Donald McMahon2, Polly Chen3, Kavita Pandit3, Clifford Rosen6, Elizabeth Shane2. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA, 4Helen Hayes Hospital, USA, 5Creighton University Osteoporosis Research Center, USA, 6Maine Medical Center, USA Disclosures: Adi Cohen, None

SA0416

Once Weekly Teriparatide on Hip Structure and Biomechanical Properties Masako Ito*1, Masao Fukunaga2, Teruki Sone2, Toshitsugu Sugimoto3, Masataka Shiraki4, Yoshiki Nishizawa5, Toshitaka Nakamura6. 1Nagasaki University Hospital, Japan, 2Kawasaki Medical School, Japan, 3Shimane University School of Medicine, Japan, 4 Research Institute & Practice for Involutional Diseases, Japan, 5Osaka City University, Japan, 6University of Occupational & Environmental Health, Japan Disclosures: Masako Ito, Chugai Pharmaceutical Company, 2; JT, 5; AsahiKasei Pharma, 5; Dai-ichi Sankyo, 5; Chugai Pharmaceutical Company, 5

SA0417

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Teriparatide Administered Transdermally in Japanese Postmenopausal Women Masako Nakano*1, Efrat Kochba2, John Stock3, Leijuj Hu3, Kazunori Uenaka4, Mika Tsujimoto4, YAEL KENAN2, Corina Loghin3. 1Eli Lilly Japan, Japan, 2TransPharma Medical Ltd., Israel, 3Eli Lilly & Company, USA, 4Eli Lilly Japan K.K, Japan Disclosures: Masako Nakano, Eli Lilly Japan, 3

SA0418

Teriparatide and Antiresorptive Combination Treatment subsequent to 9 Months of Teriparatide Monotherapy Christian Muschitz*1, Roland Kocijan2, Astrid Fahrleitner-Pammer3, Friederike Ku¨hne 4, Christina Bittighofer4, Angela Trubrich4, Reinhart Waneck5, Heinrich Resch6. 1St. Vincent’s Hospital, Austria, 2St.Vincent Hospital Vienna, Austria, 3Medical University Graz - division of Endocrinology & Metabolism, Department of Internal Medicine, Austria, 4The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 5St. Vincent Hospital - Department of Radiology, Austria, 6Medical University Vienna, Austria Disclosures: Christian Muschitz, None

SA0419

Teriparatide has Different Effects on Trabecular and Cortical Bone as Measured by 18FFluoride Positron Emission Tomography Michelle Frost*1, Musib Siddique1, Glen M. Blake1, Amelia EB. Moore1, Paul J. Schleyer1, Paul K Marsden1, Richard Eastell2, Ignac Fogelman3. 1King’s College London, United Kingdom, 2University of Sheffield, United Kingdom, 3Guy’s Hospital, United Kingdom Disclosures: Michelle Frost, Lilly, 2

SA0420

Use of Teriparatide in Patients with Atypical Femur Fractures Angela Cheung*1, Lianne Tile2, Neal Austin1, Savannah Cardew3, Heather McDonaldBlumer4, Rowena Ridout5, Robert Josse 6, Judite Scher7, Jonathan Adachi8. 1University Health Network, Canada, 2University of Toronto, Can, 3University of Toronto, Canada, 4 Mount Sinai Hospital, Canada, 5Toronto Western Hospital, Canada, 6St. Michael’s Hospital, University of Toronto, Canada, 7University Health Network, Canada, Canada, 8 St. Joseph’s Hospital, Canada Disclosures: Angela Cheung, None

106

OSTEOPOROSIS TREATMENT (CLINICAL): BISPHOSPHONATES SA0421

A Single Dose of Zoledronic Acid Prevents Periprosthetic Bone Loss in Female Patients with Cementless Total Hip Arthroplasty Hannu Aro*1, Niko Moritz1, Petteri Lankinen1, Satu Timlin2, Erkki Svedstro¨m 2. 1 University of Turku, Finland, 2Turku University Hospital, Finland Disclosures: Hannu Aro, Novartis, 2; Stryker Inc, 2; Novartis, 8

SA0422

Atypical Subtrohanterian Fracture : An Easy to Find Situation in a Particular Patient with Compromised Bone Structure Treated for Osteoporosis Carmen Barbu1, Laura Chivu1, Cristina Stefan2, Suzana Florea3, Dariana Ionita3, Cristian Burnei1, Dan Barbu1, CATALINA POIANA*4, Simona Fica1. 1Carol Davila University, Romania, 2Elias Hospital Endocrinology, Romania, 3Elias Hospital, Romania, 4AMGEN ROMANIA, Romania Disclosures: CATALINA POIANA, None

SA0423

Bisphosphonates and acute kidney injury. Safety signal identification in the Food and Drug Administration Adverse events reporting system (FDA AERS): A Report from the Research on Adverse Drug events And Reports (RADAR) Project Beatrice Edwards*1, Sarah Usmani2, Dennis Raisch3, June McKoy4, Steve Belknap5, Athena Samaras5, Dustin Liebling4, Jaimee Holbrook5, Craig Langman6, Ali Abu Alfa7, Dennis P. West 5. 1Northwestern University Medical School, USA, 2Northwestern UniversityHospital, USA, 3University of New Mexico College of Pharmacy, USA, 4 Northwestern University, Division of Geriatrics, USA, 5Northwestern University, Department of Dermatology, USA, 6Children’s Memorial Hospital, USA, 7Yale School of Medicine, Division of Nephrology, USA Disclosures: Beatrice Edwards, Dr. Edwards reports having served as a speaker for Eli Lilly and Company, Warner Chilcott, and Amgen., 8

Combination Therapy with Ibandronate and Calcitrol Is Effective in Patients Following Liver Transplantation (LTX): A Three Year Prospective Controlled Study Doris Wagner*1, KARL FENZL2, Hans Dimai3, Harald Dobnig4, Karin Amrein1, Daniela Kniepeiss 1, Philipp Stiegler1, Astrid Fahrleitner-Pammer3. 1Medical University of Graz, Austria, 2ROCHE AUSTRIA GMBH, Austria, 3Medical University Graz, Austria, 4 Diagnostikinstitut Dr.B.Fueger, Institute for Endocrine & Bone Diseases, Aut Disclosures: Doris Wagner, None

SA0425

Effect of Ibandronate for the Treatment of Osteonecrosis of the Knee: A Randomized, DoubleBlind, Placebo-Controlled Trial Christian Meier*1, Claude Kraenzlin2, Niklaus Friederich 3, Thorsten Wischer4, Leticia Grize5, Christoph Meier6, Marius Kraenzlin1. 1Div. of Endocrinology, Diabetes & Metabolism, University Hospital Basel, Switzerland, 2Endocrine Clinic & Laboratory, Basel, Switzerland, 3Dept. of Orthopedic Surgery, Bruderholz, Switzerland, 4Dept. of Radiology, Merian Iselin Hospital, Basel, Switzerland, 5Biostatistics & Computational Sciences Unit, Dept. of Epidemiology, Swiss Tropical & Public Health Institute; University of Basel, Switzerland, 6Div. of Clinical Pharmacology & Toxicology, University Hospital Basel, Switzerland Disclosures: Christian Meier, None

SA0426

Effects of Bisphosphonate on Bone Metabolic Markers, Bone Mineral Density and Vertebral Fractures in Young-Old or Old-Old Osteoporotic Patients Yuji Kasukawa* 1, Naohisa Miyakoshi1, Toshihito Ebina2, Toshiaki Aizawa2, Yoichi Shimada3. 1Akita University Graduate School of Medicine, Japan, 2Kakunodate General Hospital, Japan, 3Akita University Graduate School of Medicine, Department of Orthopedic Surgery, Japan Disclosures: Yuji Kasukawa, None

SA0427

Incidence of Fragility Fractures of the Femur, Including Subtrochanteric, up to 8 Years Since Initiation of Alendronate or Risedronate Treatment Michael Pazianas*1, Bo Abrahamsen2, Yiting Wang3, Graham Russell1. 1University of Oxford, United Kingdom, 2Copenhagen University Hospital Gentofte, Denmark, 3Warner Chilcott Pharmaceuticals (former employee), USA Disclosures: Michael Pazianas, Warner Chilcott, 5

107

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SA0424

SA0428

Long Term Follow up of Patients on Drug Holiday from Bisphosphonates: Real World Setting Jim Sinacore1, Pauline Camacho2, Lauren Myers*3. 1Loyola University Medical Center, USA, 2Loyola University of Chicago, USA, 3Loyola University Medical Center, Maywood, Illinois, USA Disclosures: Lauren Myers, None

SA0429

Long-Term Impact of Adherence to Oral Bisphosphonates on Osteoporotic Fracture Incidence John S. Sampalis*1, Jonathan Adachi2, Emmanouil Rampakakis3, Julie Vaillancourt3, Angela Karellis 3, Christian Kindundu4. 1McGill University & Jewish General Hospital, Canada, 2St. Joseph’s Hospital, Canada, 3JSS Medical Research, Canada, 4Novartis, Canada Disclosures: John S. Sampalis, JSS Medical Research, 4

SA0430

Multiple Studies with Risedronate Demonstrate Consistent Bone Turnover Regardless of Dose Robert Recker*1, Louis-Georges Ste-Marie2, Pascale Chavassieux 3. 1Creighton University Osteoporosis Research Center, USA, 2Hospital Saint-Luc, CHUM, Canada, 3INSERM, UMR1033, Universite´ de Lyon, France Disclosures: Robert Recker, NPS Allelix, 2; Procter & Gamble, 2; Merck, 5; GlaxoSmithKline, 5; Amgen, 2; Merck, 2; Roche, 5; Amgen, 5; Lilly, 2; Novartis, 2; Wyeth, 2; NPS Allelix, 5; Lilly, 5; Procter & Gamble, 5; Wyeth, 5; Novartis, 5; Roche, 2; GlaxoSmithKline, 2

SA0431

Risedronate Improves Proximal Femur Bone Mineral Density and Geometry Parameters Over 3 Years in Patients with Osteoporosis or Osteopenia and Clinical Risk Factors of Fractures: A Practice-Based Observational Study Masayuki Takakuwa*1, Jun Iwamoto2. 1Takakuwa Orthopedic Nagayama Clinic, Japan, 2 Keio University School of Medicine, Japan Disclosures: Masayuki Takakuwa, None

SA0432

ZOOM-NIS: Zoledronic acid - Osteoporosis Monitoring (a non-interventional study) Ruediger Moericke*1, Christian Kasperk2, Christine Kleinmond3. 1Germany, 2University of Heidelberg, Germany, 3Novartis Pharma GmbH, Germany Disclosures: Ruediger Moericke, None

OSTEOPOROSIS TREATMENT (CLINICAL): COMPLIANCE AND PERSISTENCE SA0433

Adherence with Intravenous Zoledronic Acid and Ibandronate for Osteoporosis among U.S.Medicare Beneficiaries Jeffrey Curtis*, Huifeng Yun, Robert Matthews, Kenneth Saag, Elizabeth Delzell. University of Alabama at Birmingham, USA Disclosures: Jeffrey Curtis, Amgen, 2; Proctor and Gamble, 2; Roche, 2; Novartis, 5; Novartis, 2; Amgen, 5; Roche, 5; Merck, 5; Merck, 2; Eli Lilly, 5; Eli Lilly, 2

SA0434

Factors Related to Permanent Discontinuation of Osteoporosis Treatment Ryan Outman1, Jeffrey Curtis1, Julie Locher1, Meredith Kilgore2, Kenneth Saag1, Cornelis Van Den Bogert*1, Amy Mudano1, Elizabeth Kitchin1, Lang Chen 3. 1University of Alabama at Birmingham, USA, 2University of Alabama At Birmingham School of Public Health, USA, 3UAB CERTs, USA Disclosures: Cornelis Van Den Bogert, None

SA0435

Feasibility and Efficacy of Computer-assisted Quantitative Morphometry (MorphoXpressH) of Vertebral Fractures in Patients before, after and at 12 Month Follow Up of Kyphoplasty Treatment Jan Banzer*1, Sebastian Radmer2, Gerd Moeller3, Hans-Christof Schober4, Reimer Andresen5. 1Charite´ Universita¨tsmedizin Berlin, Germany, 2Zentrum fu¨r Bewegungsheilkunde, Germany, 3Amgen (Europe) GmbH, Switzerland, 4Klinikum Su¨dstadt RostockKlinik Fu¨r Innere Medizin I, Germany, 5Westku¨stenklinikum Heide, Department of Radiology & Neuroradiology, Germany Disclosures: Jan Banzer, None

SA0436

Patients Reject the Concept of Fragility Fracture - A New Understanding Based on Fracture Patients’ Communication of their Fracture Joanna Sale*1, Monique Gignac2, Lucy Frankel 1, Gillian Hawker 3, Dorcas Beaton1, Victoria Elliot-Gibson 1, Earl Bogoch1. 1St. Michael’s Hospital, Canada, 2University Health Network, Canada, 3Women’s College Hospital, Canada Disclosures: Joanna Sale, None

108

SA0437

Persistence and Compliance with Osteoporosis Medical Treatment - Analysis of a Large Scale, Representative, Longitudinal, German Database Volker Ziller* 1, Karel Kostev2, Ioannis Kyvernitakis3, Jelena Boeckhof3, Peyman Hadji4. 1 Philipps-University-Marburg, Germany, 2IMS HEALTH GmbH & Co. OHG, Germany, 3 Philipps-University, Germany, 4Philipps-University of Marburg, Germany Disclosures: Volker Ziller, None

SA0438

Population-Based Trends in BMD Testing and Osteoporosis Treatment for New Initiations of Long-Term Systemic Glucocorticoids (1998-2008) Sumit Majumdar*1, Lisa M. Lix2, Colleen Metge3, Suzanne Morin4, Marina Yogendran3, William Leslie3. 1University of Alberta, Canada, 2University of Saskatchewan, Canada, 3 University of Manitoba, Canada, 4McGill University Health Centre, Canada Disclosures: Sumit Majumdar, None

SA0439

Predicting Adherence among Women Participating in the Global Longitudinal Registry of Osteoporosis in Women Jeffrey Curtis*1, Allison Wyman2, Gordon FitzGerald2, Adolfo Diez-Perez3, Stephen Gehlbach 4, Christian Roux5, Kenneth Saag1, Ethel Siris 6, Stuart Silverman7. 1University of Alabama at Birmingham, USA, 2University of Massachusetts Medical Center, USA, 3 Autonomous University of Barcelona, Spain, 4University of Massachusetts, USA, 5 Hospital Cochin, France, 6Columbia University College of Physicians & Surgeons, USA, 7 Cedars-Sinai/UCLA, USA Disclosures: Jeffrey Curtis, Merck, 5; Amgen, 2; Merck, 2; Eli Lilly, 5; Amgen, 5; Roche, 2; Roche, 5; Novartis, 2; Proctor and Gamble, 2; Novartis, 5; Eli Lilly, 2

SA0440

The effect of enhanced Dual-energy Xray Absiorptiometry (DXA) reports on osteoporosis care Karen Barnard*1, Cathleen Colon-Emeric2. 1Duke University Medical Center, Durham VAMC, USA, 2Duke University & Durham VAMC, USA

SA0441

Use of Pharmacologic Agents for the Prevention of Osteoporosis among Older Women with Low Bone Mass is Discordant with NOF Guidance Jie Zhang*, Jeffrey Curtis, Elizabeth Delzell, Kenneth Saag. University of Alabama at Birmingham, USA Disclosures: Jie Zhang, Amgen, 2

OSTEOPOROSIS TREATMENT (CLINICAL): GONADAL STEROIDS AND SERMS SA0442

Evaluation of Effect of Raloxifene Hydrochloride on the Quality of Life of Patients with Postmenopausal Osteoporosis Kousei Yoh1, Etsuro Hamaya2, Noriko Iikuni3, Noriko Takagaki 2, Takanori Yamamoto2, Masanori Taketsuna2, Akimitsu Miyauchi4, Hideaki Sowa5, Hisashi Urushihara 2, Kiyoshi Tanaka*6. 1Department of Orthopedic Surgery, Sasayama Hospital, Japan, 2Eli Lilly Japan KK, Japan, 3Eli Lilly & Company, USA, 4Miyauchi Medical Center, Japan, 5Lilly Research Laboratories Japan, Eli Lilly Japan K.K., Japan, 6Kyoto Women’s University, Japan Disclosures: Kiyoshi Tanaka, Eli Lilly Japan KK, 5

OSTEOPOROSIS TREATMENT (CLINICAL): HEALTH ECONOMICS SA0443

Cost Effectiveness of A Targeted Intervention To Reduce Refracture Rates: Analysis of A Four Year Prospective Controlled Study Mark Cooper*1, Kirtan Ganda2, Andrew Palmer3, Markus J Seibel4. 1University of Birmingham, United Kingdom, 2Australia, 3University of Tasmania, Australia, 4Bone Research Program, ANZAC Research Institute, University of Sydney, Australia Disclosures: Mark Cooper, None

SA0444

Global Health Care Utilization Following a Fracture: The Global Longitudinal Study of Osteoporosis in Women George Ioannidis*1, Julie Flahive2, Laura Pickard1, Alexandra Papaioannou3, Roland Chapurlat4, Kenneth Saag5, Stuart Silverman6, Stephen Gehlbach7, Jonathan Adachi8. 1 McMaster University, Canada, 2University of Massachusetts Medical School, USA, 3 Hamilton Health Sciences, Canada, 4E. Herriot Hospital, France, 5University of Alabama at Birmingham, USA, 6Cedars-Sinai/UCLA, USA, 7University of Massachusetts, USA, 8St. Joseph’s Hospital, Canada Disclosures: George Ioannidis, None

109

Saturday

Disclosures: Karen Barnard, None

SA0445

Rates of Diagnosis and Treatment of Osteoporosis in Males Before and After Hip, Vertebral, and Non-Hip/Non-Vertebral (NHNV) Fractures Susan Brenneman1, Laura Christensen1, Nicole Yurgin*2. 1Innovus, USA, 2Amgen Inc, USA Disclosures: Nicole Yurgin, UnitedHealth Group, 3

OSTEOPOROSIS TREATMENT (CLINICAL): OTHER AGENTS SA0446

Discontinuation of Denosumab and Associated Fracture Incidence: Analysis From the FREEDOM Trial Jacques P. Brown*1, Jens-Erik Beck Jensen2, Nigel Gilchrist3, Chris Recknor4, Christian Roux5, Ove Tørring6, Matt Austin7, Andrea Wang7, Andreas Grauer7, Rachel B. Wagman7. 1CHUQCHUL Research Centre, Canada, 2Hvidovre Hospital, Denmark, 3Canterbury Geriatric Medical Research Trust, New Zealand, 4United Osteoporosis Centers, USA, 5Paris Descartes University, France, 6Karolinska Institutet So¨dersjukhuset, Sweden, 7Amgen Inc., USA Disclosures: Jacques P. Brown, Amgen Inc., Eli Lilly, Merck, Novartis, sanofi-aventis, Warner Chilcott, 5; Abbott, Amgen Inc., Bristol-Myers Squibb, Eli Lilly, Merck, Novartis, Pfizer, Roche, sanofi-aventis, Servier and Warner Chilcott, 2; Amgen Inc., Eli Lilly, Novartis, 8

SA0447

Do our People Meet the IOM Recommendations on Calcium Dietary Intake? Cristina Carbonell*1, Daniel Prieto-Alhambra2, Carmen Olmos 3, Isabel Aymar4, Adolfo Dı´ez-Pe´rez5, Xavier Nogues5. 1Healthy Primary Care Via Roma Barcelona.Facultat de Medicina Universitat de Barcelona, Spain, 2Department of Internal Medicine, URFOA IMIM-Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona, IDIAP Jordi Gol, Barcelona, Spain, Spain, 3Healthy Primary Care Via Roma Barcelona, Spain, 4 Densitometry Unit. URFOA Hospital del Mar. Barcelona, Spain, 5Department of Internal Medicine, URFOA IMIM-Hospital,RETICEF(Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain del Mar, Parc de Salut Mar, Autonomous University of Barcelona,, Spain;, Spain Disclosures: Cristina Carbonell, None

SA0448

Effect of a New Sustained-release Formulation of the Novel Cathepsin K Inhibitor, ONO5334, on Serum and Urine Biochemical Markers of Bone Turnover in Healthy Postmenopausal Women Shinichi Nagase1, Yoshitaka Hashimoto 2, Maria Small1, Mitchy Ohyama2, JUNICHIRO MANAKO 2, Tomohiro Kuwayama1, Stephen Deacon*3. 1ONO PHARMA UK LTD, United Kingdom, 2Ono Pharmaceutical Co., Ltd., Japan, 3Ono Pharma, United Kingdom Disclosures: Stephen Deacon, Ono Pharma UK Ltd, 3

SA0449

Effect of the Cathepsin K Inhibitor, ONO-5334, on Biochemical Markers of Bone Turnover in the Treatment of Postmenopausal Osteopenia or Osteoporosis: 2-Year Results from the OCEAN Study Richard Eastell*1, Shinichi Nagase2, Maria Small 2, Steven Boonen3, Tim Spector4, Tomohiro Kuwayama2, Stephen Deacon5. 1University of Sheffield, United Kingdom, 2 ONO PHARMA UK LTD, United Kingdom, 3Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 4King’s College London, United Kingdom, 5Ono Pharma, United Kingdom Disclosures: Richard Eastell, Warner Chilcott, 2; Amgen, 5; Inverness Medical, 5; Novartis, 5; Fonterra Brands, 5; Lilly, 5; Medtronics, 5; Ono Pharma, 5; Unilever, 5; AstraZeneca, 5; Amgen, 2; Nastech, 5; AstraZeneca, 2; Unipath, 5; GSK, 5; Past president ECTS, Member of MRC Efficacy and Mechanism Evaluation Board, 6; Sanofi Aventis, 5; Nestle, 5; Lilly, 2

SA0450

Effect of two years Dietary Hesperidin Supplementation on Bone Metabolism in Postmenopausal Women Veronique Habauzit1, Elizabeth Offord2, Winnie Chee3, Lydia Jafrelo 1, Laurent Ameye2, Gary Williamson 4, Marie-noelle Horcajada* 2. 1INRA, France, 2Nestle´, Switzerland, 3 National University of Malaysia, Malaysia, 4Nestle´, France Disclosures: Marie-noelle Horcajada, None

SA0451

Effects of Strontium on the Quality of Bone Apatite Crystals Audrey Doublier*1, Delphine Farlay 2, Xavier Jaurand3, Ruben Ve´ra 4, Georges Boivin5. 1 INSERM UMR 1033; Universite´ de Lyon, France, 2INSERM UMR1033; Universite´ de Lyon, France, 3Universite´ de Lyon, Centre technologique des microstructures, F-69622, France, 4Universite´ de Lyon, Centre de diffractome´trie Henri Longchambon, F-69622, France, 5INSERM, UMR 1033 ; Universite de Lyon, France Disclosures: Audrey Doublier, Servier Laboratories, 2

110

SA0452

Therapy With Strontium Ranelate Improves Bone Mineral Mass,Volumetric Bone Mineral Density and Geometrical Parameters of Bone in Postmenopausal Osteoporotic Women2Years Results. A Peripheral Quantitative Computed Tomography (PQCT) of the Tibia Study. Konstantinos Stathopoulos*1, Erato Atsali1, Ilias Bournazos 2, Aristidis B. Zoubos1, Grigoris Skarantavos 3. 1"Attikon" Athens University Hospital, Greece, 2 "Attikon" Athens University Hospital, Greece, 3Attikon University Hospital, Greece Disclosures: Konstantinos Stathopoulos, None

SA0453

Treatment with the Cathepsin K Inhibitor Odanacatib in Postmenopausal Women with Low BMD: 5 Year Results of a Phase 2 Trial Neil Binkley*1, Henry Bone2, Nigel Gilchrist3, Bente Langdahl4, Heinrich Resch5, Jose Rodriguez-Portales6, Albert Leung7, Antonio Lombardi8, Celine Le Bailly De Tilleghem9, Carolyn DaSilva8, Elizabeth Rosenberg8, Andrew Denker8. 1University of Wisconsin, USA, 2Michigan Bone & Mineral Clinic, USA, 3Department of Orthopaedic Medicine & Surgery, Christchurch Hospital, New Zealand, 4Aarhus Sygehus, Aarhus University Hospital, Denmark, 5Medical University Vienna, Austria, 6Pontificia Universidad Cato´lica de Chile, Chile, 7Merck Research Laboratories, USA, 8Merck & Co., Inc., USA, 9Merck & Co., Inc., Belgium Disclosures: Neil Binkley, Merck, 2

OSTEOPOROSIS TREATMENT (CLINICAL): QUALITY OF LIFE SA0454

Effects of Calcitonin Treatment in Patients with Osteoporosis Who Developed Acute Low Back Pain Due to a New Vertebral Fracture Keiji Fujino1, Naoto Endo2, Shinya Tanaka*3. 1Fujino Orthopaedic Clinic, Japan, 2Niigata University, Japan, 3Saitama Medical University, Japan Disclosures: Shinya Tanaka, None

Patient Education in the Digital Age Jay Ginther*. Cedar Valley Bone Health Institute, USA Disclosures: Jay Ginther, Eli Lilly, 5; Eli Lilly, 8; BoneDocBlog.com, 4; Cedar Valley Bone Health Institute of Iowa, 4

SA0456

Relative Importance of Attributes that Influence Osteoporosis Decision-Making in Postmenopausal Women Stuart Silverman1, Andrew Calderon2, Amy Mofield3, Wendy Brynildsen 4, Michael Koenig2, Kristina Kaw2, Deborah Gold*3. 1Cedars-Sinai/UCLA, USA, 2OMC Research, USA, 3Duke University Medical Center, USA, 4Duke University, USA Disclosures: Deborah Gold, None

OSTEOPOROSIS TREATMENT (CLINICAL): VITAMIN D AND METABOLITES SA0457

Annual Bone Loss in Postmenopausal Women is Attenuated with 1000 IU but not 400 IU Daily Vitamin D3: A 1 Year Double Blind RCT Designed to Include Seasonal Effects at High Latitude Adrian Wood1, Lorna Aucott1, Alexandra Mavroeidi2, Karen Secombes 1, Alison Black3, William Fraser4, David Reid1, Helen Macdonald*5. 1University of Aberdeen, United Kingdom, 2University of Aberdeen, School of Medical Sciences, College of Life Sciences, United Kingdom, 3Woolmanhill Hospital Aberdeen Osteoporosis Research Unit, United Kingdom, 4Royal Liverpool University Hospital, United Kingdom, 5University of Aberdeen Bone & Musculoskeletal Research Programme, United Kingdom Disclosures: Helen Macdonald, None

SA0458

Fermented Milk Enriched with Calcium and Vitamin D and Anthocyans Improves Bone Metabolism in Postmenopausal Women caroline puel1, Veronique Coxam*2, MJ Davicco3, patrice lebecque3, Yohann Wittrant4. 1 ELVIR, France, 2INRA Theix, France, 3INRA, France, 4Institut National de la Recherche Agronomique, France Disclosures: Veronique Coxam, None

111

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SA0455

SA0459

Vitamin D Serum Levels Influence Adequate Response To Bisphosphonate Treatment In Postmenopausal Osteoporosis Angels Martinez-Ferrer*1, Pilar Peris 2, Ana Monegal3, M. Jesu´s Martinez de Osaba4, Africa Muxı´3, Nuria Guanabens5. 1Hospital Clinic Barcelona, Spain, 2Rheumatology. Hospital Clinic, Spain, 3Metabolic Bone Diseases Unit. Hospital Clı´nic. University of Barcelona., Spain, 4Hormonal Laboratory. Hospital Clinic., Spain, 5Universitat De Barcelona, Spain Disclosures: Angels Martinez-Ferrer, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): ANABOLIC AGENTS SA0460

Determination of Intermittent PTH(1-34) Regimens Sufficient to Restore Trabecular Bone Mass in Adult Ovariectomized Osteopenic Rats Jukka Morko*1, ZhiQi Peng1, Jukka Va¨a¨ra¨niemi1, Mari Suominen1, Katja Fagerlund1, Tiina A. Suutari1, Jukka P. Rissanen1, Harrie C.M. Boonen2, Trine S.R. Neerup3, Hanne H. Bak3, Jussi Halleen1. 1Pharmatest Services Ltd, Finland, 2Department of Pharmacology & Pharmacotherapy, University of Copenhagen, Denmark, 3Zealand Pharma A/S, Denmark Disclosures: Jukka Morko, Pharmatest Services Ltd, 3

SA0461

Effect of Estrogen Deficiency in Sclerostin Knockout Mice Min Liu*, Pam Kurimoto, Qing-Tian Niu, Hua Zhu Ke. Amgen Inc., USA Disclosures: Min Liu, Amgen Inc., 1; Amgen Inc., 3

SA0462

Effect of Vitamin K2 on Cortical and Cancellous Bone Mass and Hepatic Lipids in Rats with Combined Methionine-Choline Deficiency Jun Iwamoto* 1, Azusa Seki2, Hideo Matsumoto1. 1Keio University School of Medicine, Japan, 2Hamri Co., Ltd., Japan Disclosures: Jun Iwamoto, None

SA0463

Exported 18kDa Isoform of Fibroblast Growth Factor-2 Improved Bone Regeneration in Critical Size Mice Calvarial Defects Daisuke Ueno*1, Liping Xiao2, Liisa Kuhn2, Marja Marie Hurley3. 1Tsurumi University, Japan, 2University of Connecticut Health Center, USA, 3University of Connecticut Health Center School of Medicine, USA Disclosures: Daisuke Ueno, None

SA0464

JTT-305 (MK-5442), an Orally Active Calcium-Sensing Receptor Antagonist, Stimulates Transient Parathyroid Hormone Release and Bone Formation Shuichi Kimura*, Takashi Nakagawa, Yoshihisa Okamoto, Yuji Ishida, Yushi Matsuo, Yuko Shinagawa, Mikio Hayashi. Central Pharmaceutical Research Institute, JAPAN TOBACCO INC., Japan Disclosures: Shuichi Kimura, JAPAN TOBACCO INC., 3

SA0465

Sclerostin Antibody Enhances Distraction Osteogenesis in Rats David Little*1, Oliver Birke1, Michelle McDonald1, Kathy Mikulec 1, Lauren Peacock1, Alyson Morse1, Min Liu2, Hua Zhu Ke3. 1The Children’s Hospital At Westmead, Australia, 2Amgen, USA, 3Amgen, Inc., USA Disclosures: David Little, Amgen Inc, 2

SA0466

The Tamoxifen Metabolite, Endoxifen, has Anabolic Actions on the Skeleton John Hawse*1, Malayannan Subramaniam 2, Muzaffer Cicek2, Kevin Pitel3, Kenneth Peters4, Sarah Grygo4, Xianglin Wu4, Glenda Evans2, James Ingle4, Matthew Goetz4, Thomas Spelsberg2. 1Mayo Clinic College of Medicine, USA, 2Mayo Clinic, USA, 3 University of Minnesota, USA, 4Mayo Clinic College of Medicine, USA Disclosures: John Hawse, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): BISPHOSPHONATES SA0467

Correlations Between Serum Levels of TGF-b1 and Bone Mineralization or Bone Strength Following Prolonged Bisphosphonate Treatments Junjing Jia*1, Wei Yao1, Mohammad Shahnazari 2, Zhiqiang Cheng3, Sarah Amugongo4, Min Guan5, Nancy Lane1. 1University of California, Davis Medical Center, USA, 2UCSF VA Medical Center, USA, 3University of California, San Francisco, USA, 4Department of Medicine, University of California Davis Medical Center, USA, 5University of California, at Davis Medical Center, USA Disclosures: Junjing Jia, None

112

SA0468

Effects of Endurance Running and Zoledronic Acid Treatment on Ovariectomy-induced Osteopenia in rats Tsang-hai Huang*1, Hsin-Shih Lin2, Shen-Yu S Hsieh2, Ming-Shi Chang3, Rong-Sen Yang4. 1 National Cheng-kung University, Taiwan, 2National Taiwan Normal University, Taiwan, 3 National Cheng Kung University, Taiwan, 4National Taiwan University Hospital, Taiwan Disclosures: Tsang-hai Huang, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): CALCIUM AND DIETARY FACTORS SA0469

Flaxseed Along with Low-Dose Estrogen Therapy Protects Bone Tissue by Favorably Influencing Bone Turnover in Ovariectomized Rats Sandra Sacco*1, Jianmin Chen2, Bernhard Ganss 2, Lilian U. Thompson 2, Wendy Ward2. 1 University of Toronto, Switzerland, 2University of Toronto, Canada Disclosures: Sandra Sacco, None

SA0470

Green Tea Polyphenols Supplementation Improves Bone Microstructure and Quality on Longterm High-fat-diet-induced Obese Rats Chwan-Li Shen*1, Jay Cao2, Raul Dagda1, Samuel Chanjaplammootil3, Ming-Chien Chyu3, James Yeh4. 1Texas Tech University Health Sciences Center, USA, 2USDA ARS, USA, 3Texas Tech University, USA, 4Winthrop-University Hospital, USA Disclosures: Chwan-Li Shen, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): GONADAL STEROIDS AND SERMS SA0471

Disclosures: Baoting Zhang, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): OTHER AGENTS SA0472

Anti Osteoporotic Effects of 1,4-dihydroxy-2-naphthoic acid Eiki Yamachika*1, Masakazu Matsubara2, Ken-ichiro Kita2, Kiyofumi Takabatake2, Yuki Fujita2, Nobuyoshi Mizukawa2, Tatsushi Matsumura 2, Hidetsugu Tsujigiwa3, Hitoshi Nagatsuka3, Seiji Iida2. 1Okayama University Hospital, Japan, 2Department of Oral & Maxillofacial Reconstructive Surgery, Okayama University, Japan, 3Department of Oral Pathology & Medicine, Okayama University, Japan Disclosures: Eiki Yamachika, None

SA0473

Differential Effects of Odanacatib and Alendronate on Bone Turnover in the Femoral Neck of Adult Ovariectomized Rhesus Monkeys Tara Cusick*1, Brenda Pennypacker2, Maureen Pickarski1, Le Thi Duong2. 1Merck & Co., Inc., USA, 2Merck Research Laboratories, USA Disclosures: Tara Cusick, Merck & Co., 3

SA0474

Effect of SBM on the Degree of Mineralization of Bone of OVX rats Racquel LeGeros, Ning Jiang*. New York University College of Dentistry, USA Disclosures: Ning Jiang, None

SA0475

Inhibition of GSK3 Modulates Early Biomarkers of Bone Turnover in Rats Peter S Gilmour*1, Witte Koopmann 2, Hitesh Sanganee1, Hiroki Wada1, Ashwani Bahl 1, Stefan Kavanagh1, Peter A Hall1, Katherine Escott1. 1Astrazeneca R&D, United Kingdom, 2 AstraZeneca, Sweden Disclosures: Peter S Gilmour, None

SA0476

PTH 1-34 Rescues Impaired Fracture Healing in COX-2 Deficient Mice Kiminori Yukata*1, Chao Xie 2, Tian-Fang Li 2, Jennifer Jonason2, Xinping Zhang3, Edward Schwarz2, Regis O’Keefe2. 1M.D., Ph.D, USA, 2University of Rochester, USA, 3 University of Rochester Medical Center, USA Disclosures: Kiminori Yukata, None

113

Saturday

Icaritin Exerts Beneficial Effect on Skeletal Muscle Independent of Estrogen Receptor Pathway in Rats with Established Osteoporosis Induced By Ovariectomy Baoting Zhang*1, Baosheng Guo2, Yixin He3, Ling Qin4, Ge Zhang5. 1Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 2Prince of Wales Hospital, Hong Kong, 3The Cuinese University of Hong Kong, Hong Kong, 4Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, 5Prince of Wales Hospital, Hong Kong

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): VITAMIN D AND METABOLITES SA0477

Daily Administration of Eldecalcitol (ED-71), an Active Vitamin D Analog, Increases Bone Mineral Density by Suppressing RANKL Expression In Mouse Trabecular Bone Suguru Harada*1, Toshihide Mizoguchi2, Yuko Nakamichi 2, Yasuhiro Kobayashi2, Satoshi Takeda3, Sadaoki Sakai1, Fumiaki Takahashi4, Hitoshi Saito4, Hisataka Yasuda5, Nobuyuki Udagawa2, Tatsuo Suda6, Naoyuki Takahashi2. 1Chugai Pharmaceutical Co., Ltd., Japan, 2Matsumoto Dental University, Japan, 3Chugai Pharmaceutical Co.,Ltd, Japan, 4Chugai Pharmaceutical Company, Limited, Japan, 5Oriental Yeast Company, Limited, Japan, 6Research Center for Genomic Medicine Saitama Medical School, Japan Disclosures: Suguru Harada, Chugai Pharmaceutical Co., LTD., 1

STEROID HORMONES AND RECEPTORS: CALCIUM-SENSING RECEPTORS SA0478

Activating Mutation of the Calcium Sensing Receptor: A Single Centre Experience Shaila Sukthankar*, Sarah Ehtisham, Zulf Mughal. Royal Manchester Children’s Hospital, United Kingdom Disclosures: Shaila Sukthankar, None

STEROID HORMONES AND RECEPTORS: GLUCOCORTICOIDS SA0479

Glucocorticoids Downregulate Gap Junction Function and Connexin Expression through Autophagy Dependent and Independent Pathways Rekha Kar*1, Manuel Riquelme2, Wei Yao3, Nancy Lane4, Jean Jiang 5. 1The University of Texas Health Science Center, USA, 2University of Texas Health Science Center, USA, 3 University of California, Davis Medical Center, USA, 4University of California at Davis, USA, 5University of Texas Health Science Center at San Antonio, USA Disclosures: Rekha Kar, None

SA0480

Regulation of Osteoblastic 11ß-Hydroxysteroid Dehydrogenase Type 1 Expression By NF-kB and p38 MAPK: Towards Osteoblast Specific Enzyme Inhibition Rowan Hardy*, Mohammad Ahasan, Chris Jones, Elizabeth Rabbitt, Karim Raza, Paul Stewart, Mark Cooper. University of Birmingham, United Kingdom Disclosures: Rowan Hardy, None

STEROID HORMONES AND RECEPTORS: PTH/PTHRP SA0481

Endogenous Parathyroid Hormone Is Associated with Reduced Cartilage Volume in Vivo in a Population-Based Sample of Adult Women Sharon Brennan1, Flavia Cicuttini 2, Geoff Nicholson3, Julie Pasco4, Mark Kotowicz5, Margaret Henry6, Anita Wluka*7. 11. Department of Epidemiology & Preventive Medicine, Monash University 2. Northwest Academic Centre, Western Section, Department of Medicine, The University of Melbourne, Australia, 2Department of Epidemiology & Preventive Medicine, Monash University, Australia, 3Rural Clinical School, The University of Queensland, Australia, 4Deakin University, Australia, 5Barwon Health, Australia, 6 School of Medicine, Deakin University, Australia, 7Monash University & Alfred Hospital, Australia Disclosures: Anita Wluka, None

STEROID HORMONES AND RECEPTORS: SEX STEROIDS SA0482

2011 ASBMR YOUNG INVESTIGATOR AWARD Altered Balance between Chondrocyte Apoptosis and Proliferation is Associated with Growth Plate Fusion in Mice with a Specific Inactivation of AF-1 in Estrogen Receptor (ER)-a while Total Inactivation of ERa Results in Prolonged and Enhanced Longitudinal Bone Growth Anna Borjesson*1, Sara Windahl2, Marie Lagerquist3, Cecilia Engdahl4, Elham Karimian5, Emma E Eriksson5, Maria Cristina Antal6, Andre´e Krust6, Pierre Chambon6, Lars Sa¨vendahl5, Claes Ohlsson 1. 1Centre for Bone & Arthritis Research, Sweden, 2Center for Bone & Arthritis Research, Sweden, 3Sahlgrenska University Hospital, Sweden, 4Centre for Bone & Arthritis Researc, GU, Sauhlgrenska Academy, Medicine, Sweden, 5Division of Pediatric Endocrinology, Department of Womens & Childrens Health, Karolinska Institutet, Sweden, 6Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire (CNRS, INSERM, UdS, Colle`ge de France), Illkirch, France Disclosures: Anna Borjesson, None

114

SA0483

Androgen Directly Exerts Anabolic Action through Osteoblastic Androgen Receptor Yuuki Imai*1, Min-Young Youn2, Min Ni 3, Kazuki Inoue1, Shino Kondoh1, Takahiro Matsumoto 4, Myles Brown3, Shigeaki Kato2. 1The University of Tokyo, Japan, 2University of Tokyo, Japan, 3Department of Medical Oncology, Dana-Farber Cancer Institute, USA, 4 Tokushima University, Japan Disclosures: Yuuki Imai, None

SA0484

Estrogen Receptor-Related Receptor Gamma (ERRc) Is a Regulator of Bone Turnover Marco Cardelli*1, Ruolin Guo 2, Jonathan Boetto1, Ralph Zirngibl1, Jane Aubin3. 1 University of Toronto, Canada, 2University of Rochester, USA, 3University of Toronto Faculty of Medicine, Canada Disclosures: Marco Cardelli, None

SA0485

Loss of ERa DNA Binding Suppresses Bone Gain In Vivo and In vitro Osteoblast Differentiation in the Context of a Wild-type or Null ER Alpha Allele Orhan Oz*, Asghar Hajibeigi. University of Texas Southwestern Medical Center, Dallas, USA Disclosures: Orhan Oz, None

STEROID HORMONES AND RECEPTORS: VITAMIN D AND ITS ANALOGS SA0486

A Cross talk between Prohibitin and Importin a3 in Vitamin D signaling pathway- A novel implication in allergic airway inflammation Tanupriya Agrawal*1, Gaurav Gupta1, Devendra Agrawal2. 1Creighton University, USA, 2 Creighton University School of Medicine, USA Disclosures: Tanupriya Agrawal, None

SA0487

Disclosures: Seong-Min Lee, None SA0488

A Role of Calcium in the Control of Hair Cycling Leila J. Mady*1, Dare V. Ajibade1, Arnaud Teichert2, Daniel Bikle 3, Sylvia Christakos1. 1 University of Medicine & Dentistry & New Jersey - New Jersey Medical School, USA, 2 Department of Medicine, UCSF, USA, 3Endocrine Research Unit, Division of Endocrinology UCSF, USA Disclosures: Leila J. Mady, None

SA0489

A Vitamin D3 Analog, ED-71 Facilitates Vitamin D Receptor Degradation Ken-ichi Takeyama*. The University of Tokyo, Japan Disclosures: Ken-ichi Takeyama, None

SA0490

Automated Measurement of Total 25 Vitamin D on the IDS-iSYS System Etienne Cavalier*1, Anne-Catherine Bekaert2, Agnes Carlisi2, Jean-Paul Chapelle3. 1 University of Liege, CHU Sart-Tilman, Belgium, 2University of Lie`ge, CHU Sart-Tilman, Belgium, 3University of Liege, CHU Sart-Tilman, Belgium Disclosures: Etienne Cavalier, None

SA0491

D Vitamin Levels in Children Born by Mothers with Vitamin D Deficiency Ingrid Bergstro¨m*1, Agneta Blanck2, Lars Sa¨vendahl3. 1Division of Endocrinology, Metabolism & Diabetes, Karolinska University Hospital, Huddinge, CLINTEC, Karolinska Institutet, Stockholm, Sweden, 2Unit for Obstetrics & Gynecology, Karolinska University Hospital, Huddinge, CLINTEC, Karolinska Institutet, Stockholm, Sweden, 3 Division of Pediatric Endocrinology, Karolinska University Hospital, Solna, Department of Women’s & Children’s Health, Karolinska Institutet, Stockholm, Sweden, Sweden Disclosures: Ingrid Bergstro¨m, None

SA0492

DNA Methylation Levels of CYP2R1 and CYP24A1 Predict Vitamin D Dose-response Variation Xiaojing Xu*1, YU ZHOU2, Fengxiao Bu 2, An Ye 1, Boting Zhou1, Robert Recker1, Joan Lappe1, Lanjuan Zhao3. 1Creighton University Osteoporosis Research Center, USA, 2 CREIGHTON UNIVERSITY, USA, 3Creighton University Medical Center, USA Disclosures: Xiaojing Xu, None

115

Saturday

A Human BAC Transgene Containing the Vitamin D Receptor Gene Locus Humanizes the VDR-null Mouse and Rescues the Aberrant Biological Phenotype of VDR Deficiency Seong-Min Lee*1, Kathleen Bishop1, Charles O’Brien2, J. Pike1. 1University of WisconsinMadison, USA, 2University of Arkansas for Medical Science, USA

SA0493

Enhanced Vitamin D Synthesis in Osteoblasts Protects Against Age-Related Bone Loss Paul Anderson*1, Andrew Turner2, Rebecca Sawyer1, Peter O’Loughlin3, Gerald Atkins4, Howard Morris2. 1Musculoskeletal Biology Research, University of South Australia, Australia, 2SA Pathology, Australia, 3Chemical Pathology, SA Pathology, Australia, 4 University of Adelaide, Australia Disclosures: Paul Anderson, None

SA0494

Hypercalcemia in the Elderly: Malignancy? ALVARO PUIG*1, Daisy Acevedo2, Sanford Baim1. 1Miller School of Medicine, University of Miami, USA, 2University of Miami, USA Disclosures: ALVARO PUIG, None

SA0495

The Effect of Mechanical Loading on the Regulation of 1a-hydroxylase in Primary Human Bone Cells Karen Van Der Meijden*1, Astrid Bakker2, Nathalie Bravenboer 1, Paul Lips1. 1VU University Medical Center, The Netherlands, 2ACTA - UVA & VU, RESEARCH INSTITUTE MOVE, Netherlands Disclosures: Karen Van Der Meijden, None

SPECIAL LECTURE ON SARCOPENIA 1:00 pm - 2:00 pm

Room 31ABC

Andrew Marks, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Andrew Marks, None

MEET-THE-PROFESSOR SESSIONS 1:00 pm - 2:00 pm

Rooms 24A-27A

PTH/PTHrP Signaling In Osteocyte Physiology Room 24A Paola Divieti Pajevic, M.D., Ph.D. Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Paola Divieti Pajevic, None

Phosphate Regulation of Chondrocyte Physiology and Fracture Repair Room 24B Marie Demay, M.D. Massachusetts General Hospital and Harvard Medical School, USA Disclosures: Marie Demay, None

Management of Skeletal Health in Women with Breast Cancer This session will be repeated on Sunday, September 18 at 10:00 am Room 24C Supported by an educational grant from Merck & Co., Inc. Meryl S. Leboff, M.D. Brigham and Women’s Hospital, USA Disclosures: Meryl Leboff, None

Male Osteoporosis This session will be repeated on Sunday, September 18 at 10:00 am Room 25A Eric S. Orwoll, M.D. Oregon Health and Science University, USA Disclosures: Eric Orwoll, Merck 5; Merck 2; Eli Lilly 5; Amgen 2; Wright Medical Technology 5; Amgen 5; Eli Lilly 2

Primary Hyperparathyroidism This session will be repeated on Sunday, September 18 at 10:00 am Room 25B John Bilezikian, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: John Bilezikian, None

116

Understanding and Applying HRpQCT Room 25C Sharmila Majumdar, Ph.D. University of California, San Francisco, USA Disclosures: Sharmila Majumdar, Merck 2

Elizabeth Shane, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Elizabeth Shane, None

Angiogenic Responses to Mechanical Loads Room 27A Matthew Silva, Ph.D. Washington University in St. Louis School of Medicine, USA Disclosures: Matthew Silva, None

CAREER DEVELOPMENT: BUILDING INTERDISCIPLINARY COLLABORATION IN RESEARCH Co-sponsored by the ASBMR Women in Bone and Mineral Research and Membership Development Committees 1:00 pm - 2:00 pm

Room 32AB

Panelists Mary L. Bouxsein, Ph.D. Beth Israel Deaconess Medical Center, USA Disclosures: Mary Bouxsein, None

Brendan Lee, M.D., Ph.D. Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Brendan Lee, None

Eric S. Orwoll, M.D. Oregon Health and Science University, USA Disclosures: Eric Orwoll, None

CLINICAL ROUNDTABLE/CASE CONFERENCE - ANABOLIC AGENTS FOR FRACTURE REPAIR 1:00 pm - 2:00 pm

Room 20BCD

Chair Michaela Kneissel, Ph.D. Novartis Institutes for Biomedical Research, Switzerland Disclosures: Michaela Kneissel, Novartis Institutes for BioMedical Research, Novartis Pharma AG 3

1:00 pm

The Biology of Fracture Repair Thomas A. Einhorn, M.D. Boston Medical Center, USA Disclosures: Thomas Einhorn, j and j pharma 5; healthpoint capital 1; medtronic 7; medtronic 5; smith and nephew 5; novartis 5; implant protection 1; kuros 5; lilly 5; biomineral holdings 1

117

Saturday

The ability to network and identify partners for cross-functional collaborative research endeavors is an imperative skill for scientists to acquire, especially given the current research funding climate and an increased emphasis by the health-related funding agencies on interdisciplinary sciences. In this session, a panel of speakers from basic, clinical and translational research settings will discuss their experiences in building professional networks that lead to successful interdisciplinary research undertakings, what they see as the keys to their success and strategies that others can use to broaden their own research as well as enhance their professional development.

1:30 pm

Promoting Fracture Repair in Patients with Delayed or Non-healing Fractures Robert Marcus, M.D. Stanford University, USA Disclosures: Robert Marcus, Eli Lilly & Company 9; Eli Lilly & Company 5; Eli Lilly & Company 8; Amgen 5

CONCURRENT ORAL SESSION 07: OSTEOCYTES 2:15 pm - 3:45 pm

Room 29ABCD

Moderators: Jian Q. Feng, M.D., Ph.D. Texas A&M Health Science Center, USA Disclosures: Jian Feng, None

Jeffrey P. Gorski, Ph.D. University of Missouri - Kansas City, USA Disclosures: Jeffrey Gorski, None

2:15 pm 1037

2011 ASBMR YOUNG INVESTIGATOR AWARD Osteocytes Regulate Bone Microenvironment Through Gsa Signaling to Support Normal Hematopoiesis Keertik Fulzele* 1, Daniela Krause2, Kevin Barry3, Sutada Lotinun4, Roland Baron5, Lynda Bonewald6, Jian Feng7, Min Chen8, Lee Weinstein9, David Scadden10, Paola Divieti Pajevic11. 1Massachusetts General Hospital; Harvard Medical School, USA, 2Center of Regenerative Medicine, Massachusetts General Hospital & Harvard Medical School, USA, 3 Massachusetts General Hospital & Harvard Medical School, USA, 4Harvard School of Dental Medicine, USA, 5Harvard School of Medicine & of Dental Medicine, USA, 6 University of Missouri - Kansas City, USA, 7Texas A&M Health Science Center, USA, 8 Metabolic Diseases Branch, NIDDK, NIH, USA, 9National Institute of Diabetes & Digestive & Kidney Diseases, USA, 10CENTER FOR REGENERATIVE MEDICINEMASSACHUSETTS GEN, USA, 11Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Keertik Fulzele, None

2:30 pm 1038

Conditional Knockout of IGF-I in Osteocytes Surprisingly Accelerates Fracture Repair Matilda Sheng*1, Xiaodong Zhou1, Kin-Hing William Lau2, Lynda Bonewald3, David Baylink1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3University of Missouri - Kansas City, USA Disclosures: Matilda Sheng, None

2:45 pm 1039

Osteocyte Autophagy Declines with Age in Mice and Suppression of Autophagy Decreases Bone Mass Haibo Zhao, Jinhu Xiong, Melda Onal, Priscilla Cazer, Robert Weinstein, Stavros Manolagas, Charles O’Brien*. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Charles O’Brien, None

3:00 pm 1040

2011 ASBMR YOUNG INVESTIGATOR AWARD Sclerostin Deficiency does not Induce Bone Gain in Mice Lacking Osteocyte ß-catenin Ming-Kang Chang*, Ina Kramer, Michaela Kneissel. Novartis Institutes for Biomedical Research, Switzerland Disclosures: Ming-Kang Chang, Novartis, 3

3:15 pm 1041

Increased RANKL Production by Osteocytes is a Major Mechanism Underlying the Bone Loss Induced by Unloading Jinhu Xiong*, Melda Onal, Priscilla Cazer, Stavros Manolagas, Charles O’Brien. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Jinhu Xiong, None

118

3:30 pm 1042

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway Asiri Wijenayaka, Masakazu Kogawa, David Findlay, Gerald Atkins*. University of Adelaide, Australia Disclosures: Gerald Atkins, None

CONCURRENT ORAL SESSION 08: OSTEOCLASTS 2:15 pm - 3:45 pm

Room 30CDE

Moderators: Hiroshi Takayanagi, M.D., Ph.D. Tokyo Medical and Dental University, Japan Disclosures: Hiroshi Takayanagi, None

Alberta M. Zallone, Ph.D. University of Bari Medical School, Italy Disclosures: Alberta Zallone, None

2:15 pm 1043

Deletion of the Rho-GEF Kalirin Leads to Bone Loss Due to Defects in the Function of Osteoblasts and Osteoclasts Su Huang1, Pierre Eleniste1, Cameron Carter1, Melissa Kacena2, Matthew Allen2, Angela Bruzzaniti* 1. 1Indiana University School of Dentistry, USA, 2Indiana University School of Medicine, USA Disclosures: Angela Bruzzaniti, None

2:30 pm 1044

Disclosures: Robert Brommage, Lexicon Pharmaceuticals, 3

2:45 pm 1045

2011 ASBMR YOUNG INVESTIGATOR AWARD Estrogen Indirectly Suppresses Mesenchymal Cell Migration and Mineralization by Stimulating Sclerostin and Sostdc1 Expression in Osteoclasts Kuniaki Ota*1, Patrick Quint2, Moustapha Kassem3, Jennifer Westendorf1, Sundeep Khosla4, Merry Jo Oursler1. 1Mayo Clinic, USA, 2Mayo Clinic Rochester, USA, 3Odense University Hospital, Denmark, 4College of Medicine, Mayo Clinic, USA Disclosures: Kuniaki Ota, None

3:00 pm 1046

2011 ASBMR YOUNG INVESTIGATOR AWARD Critical Role of ATF4 in Regulating Osteoclast Differentiation and Bone Resorption Huiling Cao*1, Shibing Yu2, Zhi Yao3, Deborah Galson1, Yu Jiang4, Xiaoyan Zhang5, Jie Fan4, Binfeng Lu 4, Youfei Guan5, Min Luo4, Yumei Lai4, Noriyoshi Kurihara6, Kenneth Patrene4, G. David Roodman7, Guozhi Xiao1. 1University of Pittsburgh School of Medicine, USA, 2University of Pittsburgh Medical Center, USA, 3Tianjin Medical University, China, 4University of Pittsburgh, USA, 5Peking University, China, 6Center for Bone Biology, University of Pittsburgh, USA, 7VA Pittsburgh Healthcare System (646), USA Disclosures: Huiling Cao, None

3:15 pm 1047

2011 ASBMR YOUNG INVESTIGATOR AWARD Deletion of Dynamin-1 and Dynamin-2 in Osteoclasts Shows that Dynamins are Required for the Fusion of Osteoclast Precursors and for Bone Resorption in vivo Shawn Ferguson1, William Horne2, Pietro De Camilli 1, Lynn Neff2, Hiroaki Saito2, NahYoung Shin*3, Roland Baron4. 1Yale University School of Medicine, USA, 2Harvard School of Dental Medicine, USA, 3Harvard University, USA, 4Harvard School of Medicine & of Dental Medicine, USA Disclosures: Nah-Young Shin, None

119

Saturday

Osteopetrosis in Mice with Knockout of Leucine-Rich Repeat Kinase 1 (Lrrk1) Gene Robert Brommage*1, Jeff Liu 1, Peter Vogel1, Thomas Wronski2. 1Lexicon Pharmaceuticals, USA, 2University of Florida, USA

3:30 pm 1048

Contrasting Roles of Leukemia Inhibitory Factor (LIF) in Neonatal Bone Development and Adult Bone Remodeling Involve Region-Specific Regulation of Vascular Endothelial Growth Factor (VEGF) Ingrid J Poulton, Narelle E McGregor, Sueli Pompolo, Emma C Walker, Natalie Sims*. St. Vincent’s Institute of Medical Research, Australia Disclosures: Natalie Sims, None

CONCURRENT ORAL SESSION 09: CALCIOTROPIC AND PHOSPHOTROPIC HORMONES 2:15 pm - 3:45 pm

Room 31ABC

Moderators: Peter Stanley Rowe, Ph.D. University of Kansas Medical Center, USA Disclosures: Peter Rowe, None

Mei Wan, M.D., Ph.D. Johns Hopkins University School of Medicine, USA Disclosures: Mei Wan, None

2:15 pm 1049

Autocrine/Paracrine Actions of Cyp27b1, VDR, and CaSR Signaling in the Regulation of Parathyroid Function: Studies of Parathyroid-Specific Knockout Mice Zhiqiang Cheng, Chialing Tu, Alfred Li, Michael You, Dolores Shoback, Daniel Bikle, Wenhan Chang*. University of California, San Francisco, USA Disclosures: Wenhan Chang, None

2:30 pm 1050

Conditional Deletion of the Parathyroid Hormone (PTH) Receptor 1 from Osteocytes Results in Decreased Bone Resorption and a Progressive Increase in Cancellous Bone Mass Xiaolin Tu* 1, Rachel Edwards1, Naomie Olivos1, Jeffrey Benson1, Carlo Galli 2, Gretel Pellegrini 3, Nicoletta Bivi4, Lilian Plotkin1, Teresita Bellido1. 1Indiana University School of Medicine, USA, 2Universita` Degli Studi Di Parma, Italy, 3seccion osteopatias medicas, Hospital de Clı´nicas Jose´ de San Martı´n, Argentina, 4Indiana University, USA Disclosures: Xiaolin Tu, None

2:45 pm 1051

2011 ASBMR YOUNG INVESTIGATOR AWARD PTH/PTHrP (PPR) Receptor Signaling in Osteocytes Regulate Bone Development in Temporal Manner Vaibhav Saini* 1, Kevin Barry2, Keertik Fulzele 3, Jian Feng4, Paola Pajevic Divieti5. 1 Research Fellow, MGH, Harvard Medical School, USA, 2Massachusetts General Hospital, USA, 3Massachusetts General Hospital; Harvard Medical School, USA, 4Texas A&M Health Science Center, USA, 5MGH- Harvard Medical School, USA Disclosures: Vaibhav Saini, None

3:00 pm 1052

The Calcium Sensing Receptor Synergizes with PTH in Modulating Bone Turnover Yingben Xue* 1, Yongjun Xiao2, Jingning Liu3, Andrew Karaplis4, Martin Pollak5, Edward Brown6, Dengshun Miao7, David Goltzman8. 1Calcium Research Lab, McGill University, Canada, 2the Centre for Bone & Periodontal Research, McGill University, Canada, 3 Calcium Research Laboratory, McGill University Health Centre & Department of Medicine, Canada, 4McGill University, Can, 5Renal Division, Department of Medicine, Brigham & Women’s Hospital, USA, 6Brigham & Women’s Hospital, USA, 7Nunjing Medical University, Peoples Republic of China, 8McGill University Health Centre, Canada Disclosures: Yingben Xue, None

3:15 pm 1053

Mammary-Specific Ablation of the Calcium-Sensing Receptor Gene Results in Alterations in Systemic Calcium Metabolism and Breast Calcium Transport During Lactation Ramanaiah Mamillapalli*1, Joshua VanHouten 2, Pamela Dann2, Laleh Ardeshirpour 1, Wenhan Chang3, Dolores Shoback4, Daniel Bikle 5, John Wysolmerski2. 1Yale University, USA, 2Yale University School of Medicine, USA, 3University of California, San Francisco, USA, 4VA Medical Center, USA, 5Endocrine Research Unit, Division of Endocrinology UCSF, USA Disclosures: Ramanaiah Mamillapalli, None

120

3:30 pm 1054

Skeletal Mineralization Defect of FGF23 Deficient Mice Is Mediated by Increased Osteopontin Quan Yuan*1, Yan Jiang2, Tadatoshi Sato1, Reinhold Erben3, Beate Lanske1. 1Harvard School of Dental Medicine, USA, 2Peoples Republic of China, 3University of Veterinary Medicine, Austria Disclosures: Quan Yuan, None

CONCURRENT ORAL SESSION 10: OSTEOPOROSIS ASSESSMENT: PREDICTION OF FRACTURE RISK 2:15 pm - 3:45 pm

Room 20A

Moderators: Shreyasee Amin, M.D., MPH Mayo Clinic, USA Disclosures: Shreyasee Amin, None

Eugene V. McCloskey, M.D., MRCP, M.B. University of Sheffield, United Kingdom Disclosures: Eugene McCloskey, None

2:15 pm 1055

Disclosures: John Krege, Eli Lilly & Co, 3; Eli Lilly & Co, 1

2:30 pm 1056

Recency and Duration of Glucocorticoid Use and Fracture Prediction: The Manitoba BMD Cohort William Leslie*1, Sumit Majumdar2, Suzanne Morin3, Colleen Metge1, Lisa Lix4. 1 University of Manitoba, Canada, 2University of Alberta, Canada, 3McGill University Health Centre, Canada, 4University of Saskatchewan, Canada Disclosures: William Leslie, None

2:45 pm 1057

Low Bone Turnover and Abnormal Collagen Crosslinking in Women with Atraumatic Fractures and Near- Normal BMD: A Disease Entity Different from Post-Menopausal Osteoporosis Hartmut Malluche*1, Daniel Porter2, Marie-Claude Faugere1, Hanna Mawad3, David Pienkowski2. 1University of Kentucky Medical Center, USA, 2University of Kentucky, USA, 3University of Kentucky, Division of Nephrology Bone & Mineral Metabolism, USA Disclosures: Hartmut Malluche, None

3:00 pm 1058

Is the Ability of FRAX to Predict Fractures Comparable in Obese and Non-obese Postmenopausal Women? Melissa Premaor*1, Richard Parker2, Li-Yung Lui3, Teresa Hillier4, Kristine Ensrud5, Jane Cauley6, Juliet Compston7. 1Federal University of Santa Maria, Brazil, 2Department of Public Health & Primary Care, Institute of Public Health, University of Cambridge, United Kingdom, 3California Pacific Medical Center Research Institute, USA, 4Center for Health Research, Kaiser Permanente Northwest/Hawaii, USA, 5Minneapolis VA Medical Center / University of Minnesota, USA, 6University of Pittsburgh Graduate School of Public Health, USA, 7University of Cambridge School of Clinical Medicine, United Kingdom Disclosures: Melissa Premaor, None

121

Saturday

Age, Bone Mineral Density, and Spine Fracture Status for Predicting Fracture Risk John Krege*1, Xiaohai Wan2, Brian Lentle3, Claudie Berger4, Lisa Langsetmo5, Jonathan Adachi6, Jerilynn Prior 3, Alan Tenenhouse4, Jacques Brown7, Nancy Kreiger8, Wojciech P. Olszynski 9, Robert Josse 10, David Goltzman11, CaMos Research Group11. 1Eli Lilly & Company, USA, 2Lilly USA, LLC, USA, 3University of British Columbia, Canada, 4 McGill University, Canada, 5Canandian Multicenter Osteoporosis Study, Canada, 6St. Joseph’s Hospital, Canada, 7Laval University, Canada, 8University of Toronto, Canada, 9 University of Saskatchewan, Canada, 10St. Michael’s Hospital, University of Toronto, Canada, 11McGill University Health Centre, Canada

3:15 pm 1059

Baseline BMD T-score and Time to Fracture in Older Women: the Study of Osteoporotic Fractures Margaret Gourlay*1, Jason P. Fine 2, Chenxi Li 2, John S. Preisser2, Ryan C. May 2, Li-Yung Lui3, Kristine Ensrud4. 1University of North Carolina at Chapel Hill, USA, 2University of North Carolina, USA, 3California Pacific Medical Center Research Institute, USA, 4 Minneapolis VA Medical Center / University of Minnesota, USA Disclosures: Margaret Gourlay, None

3:30 pm 1060

Height Loss Starting in Middle Age Predicts Increased Mortality in Elderly Men and Women Saeko Fujiwara*1, Naomi Masunari 2, Fumiyoshi Kasagi3, Toshitaka Nakamura4. Radiation Effects Research Foundation, Japan, 2Faculty of Pharmacy, Iwaki Meisei University, Japan, 3Depatment of Epidemiology, Radiation Effects Research Foundation, Japan, 4University of Occupational & Environmental Health, Japan 1

Disclosures: Saeko Fujiwara, None

CONCURRENT ORAL SESSION 11: OSTEOPOROSIS TREATMENT (CLINICAL): ANTI-RESORPTIVE TREATMENT 2:15 pm - 3:45 pm

Room 20BCD

Moderators: Nelson B. Watts, M.D. University of Cincinnati Bone Health and Osteoporosis Center, USA Disclosures: Nelson Watts, None

Angela M. Cheung, M.D., Ph.D. University Health Network, Canada Disclosures: Angela Cheung, None

2:15 pm 1061

Effects of Denosumab on Bone Mineral Density and Biochemical Markers of Bone Turnover: 8-Year Results of a Phase 2 Clinical Trial Michael McClung*1, E. Michael Lewiecki2, Michael A. Bolognese3, Munro Peacock4, Richard Weinstein5, Beiying Ding6, Michelle L. Geller 7, Andreas Grauer6, Rachel B. Wagman6, Paul Miller 8. 1Oregon Osteoporosis Center, USA, 2New Mexico Clinical Research & Osteoporosis Center, USA, 3Bethesda Health Research Center, USA, 4Indiana University Medical Center, USA, 5Diablo Clinical Research, Inc., USA, 6Amgen Inc., USA, 7Amgen Inc. & University of California Los Angeles, USA, 8Colorado Center for Bone Research, USA Disclosures: Michael McClung, Amgen, Merck, Warner Chilcott, 2; Amgen, Lilly, Merck, Novartis, Warner Chilcott, 5; Amgen, Lilly, Novartis, Warner Chilcott, 8

2:30 pm 1062

Effects of Denosumab on Radius BMD, Strength, and Wrist Fractures: Results From the Fracture REduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) Study J Simon1, C Recknor2, A Moffet3, J Adachi4, E Franek5, EM Lewiecki*6, CA Mautalen7, S Ragi Eis 8, GC Nicholson 9, C Muschitz10, R Nuti11, O Tørring12, A Wang13, C Libanati13. 1 George Washington University, USA, 2United Osteoporosis Centers, USA, 3OB-GYN Associates of Mid Florida, USA, 4St. Joseph’s Hospital, McMaster University, Canada, 5 Central Clinical Hospital MSWiA, Poland, 6New Mexico Clinical Research & Osteoporosis Center & University of New Mexico School of Medicine, USA, 7Centro de Osteopatias Medicas, Argentina, 8CEDOES Centro de Diagnostico e Pesquisa, Brazil, 9 Barwon Health, The Geelong Hospital, Australia, 10St. Vincent Hospital, Austria, 11 University of Siena, Italy, 12Karolinska Institutet So¨dersjukhuset, Sweden, 13Amgen Inc., USA Disclosures: EM Lewiecki, Abbott Laboratories, Agile Therapeutics, Inc., Amgen Inc., Ascend Therapeutics, Azur Pharma, Inc., BioSante, Boehringer Ingelheim, Depomed, Inc., 5; Fabre-Kramer, Laboratoire HRA Pharma, Meditrina Pharmaceuticals, Merck, Merrion Pharmaceuticals, NDA Partners, Inc., Novo Nordisk, Novogyne, Pfizer, Inc., Shionogi, Inc., 5; Amgen, Ascend, Bayer, Boehringer Ingelheim, KV, Merck, Novartis, Novo Nordisk, Novogyne, Teva, Warner Chilcott, 8; BioSante, Boehringer Ingelheim, Endoceutics, Inc., Novo Nordisk, Novogyne,Teva, 2; Slate Pharmaceuticals, Teva, Warner Chilcott, Trovis Pharmaceuticals LLC, Watson Pharmaceuticals, 5

122

2:45 pm 1063

Efficacy of Five Years of Denosumab: A Novel "Virtual Twins" Method for Minimizing Bias in Extensions of Trials Steven Cummings* 1, Nadia Daizadeh2, Eric Vittinghoff3, Cesar Libanati2, Jacques P Brown4, Christian Roux5, Matthew Austin2, Andreas Grauer2, Socrates Papapoulos 6, Henry G Bone7. 1San Francisco Coordinating Center, USA, 2Amgen Inc., USA, 3 University of California, San Francisco, USA, 4CHUQ-CHUL Research Centre, Laval University, Canada, 5Paris Descartes University, France, 6Leiden University Medical Center, Netherlands, 7Michigan Bone & Mineral Clinic, USA Disclosures: Steven Cummings, Amgen Inc., 5

3:00 pm 1064

The Transitory Increase in PTH Following Denosumab Administration is Associated With Reduced Intracortical Porosity: a Distinctive Attribute of Denosumab Therapy Ego Seeman*1, Cesar Libanati2, Matt Austin2, Roland Chapurlat3, Steven Boyd4, Roger Zebaze1, David A. Hanley4, Jose R. Zanchetta5, Andreas Grauer2, John P. Bilezikian6. 1 Austin Health, University of Melbourne, Australia, 2Amgen Inc., USA, 3INSERM UMR 1033, Universite´ de Lyon, France, 4University of Calgary, Canada, 5Instituto de Investigaciones Metabo´licas, Argentina, 6College of Physicians & Surgeons, Columbia University, USA Disclosures: Ego Seeman, Amgen Inc., MSD, Servier, 2; Amgen Inc., Novartis, Eli Lilly, Warner Chilcott, 8; Amgen Inc., Novartis, Warner Chilcott, Servier, 5

3:15 pm 1065

Disclosures: Henry G Bone, Novartis, Tarsa, Amgen, and Merck, 5; Nordic Bioscience, Amgen, and Merck, 2; Amgen, 8

3:30 pm 1066

Reduction in Incidence of Vertebral Fractures with Once Yearly Zoledronic Acid in Men with Osteoporosis Steven Boonen*1, Jean-Marc Kaufman2, Jean-Yves Reginster3, Rene Rizzoli4, Kurt Lippuner5, Dirk Vanderschueren 6, Josef Hruska7, Oscar Antunez8, Philemon Papanastasiou7, Guoqin Su8, Eric Orwoll9. 1Katholieke Universiteit Leuven, Belgium, 2 University Hospital of Ghent, Belgium, 3University of Liege, Belgium, 4University Hospitals & Faculty of Medicine of Geneva, Switzerland, 5Osteoporosis Policlinic, University of Bern, Switzerland, 6Leuven University Hospital, Belgium, 7Novartis Pharma AG, Switzerland, 8Novartis Pharmaceuticals, USA, 9Oregon Health & Science University, USA Disclosures: Steven Boonen, Novartis, 2; Novartis, 5

CONCURRENT ORAL SESSION 12: BONE BIOMECHANICS AND QUALITY: ANIMAL MODELS 2:15 pm - 3:45 pm

Room 32AB

Moderators: Robert R. Recker, M.D. Creighton University Osteoporosis Research Center, USA Disclosures: Robert Recker, None

Alexander G. Robling, Ph.D. Indiana University, USA Disclosures: Alexander Robling, None

123

Saturday

Safety Observations From Denosumab Long-term Extension and Cross-over Studies in Postmenopausal Women With Osteoporosis Henry G Bone*1, Roland Chapurlat2, Cesar Libanati3, Maria L Brandi4, Jacques P Brown5, Edward Czerwinski6, Marc-Antoine Krieg7, Zulema Man8, Dan Mellstro¨m 9, Sebastia˜o C Radominski10, Jean-Yves Reginster11, Heinrich Resch12, Jose´ A. Roma´n Ivorra13, Christian Roux14, Nadia S Daizadeh3, Andreas Grauer3, Steve R Cummings 15, Socrates Papapoulos 16. 1Michigan Bone & Mineral Clinic, USA, 2Hoˆpital Edouard Herriot, France, 3Amgen Inc., USA, 4University of Florence, Italy, 5CHUQ-CHUL Research Centre, Laval University, Canada, 6Krakow Medical Centre, Poland, 7University Hospital of Lausanne, Switzerland, 8Centro Me´dico TIEMPO, Argentina, 9University of Gothenburg, Sweden, 10Universidade Federal do Parana´, Brazil, 11University of Lie`ge, Belgium, 12St. Vincent’s Hospital, Austria, 13Hospital Universitario La Fe, Spain, 14Paris Descartes University, France, 15San Francisco Coordinating Center, CPMC Research Institute, USA, 16Leiden University Medical Center, Netherlands

2:15 pm 1067

PTH Receptor 1 Expression in Osteocytes Is Indispensable for the Anabolic Effect of Mechanical Loading in Mice Xiaolin Tu* 1, Gretel Pellegrini 2, Carlo Galli 3, Jeffrey Benson1, Keith Condon1, Nicoletta Bivi4, Lilian Plotkin1, Alexander Robling4, Teresita Bellido1. 1Indiana University School of Medicine, USA, 2seccion osteopatias medicas, Hospital de Clı´nicas Jose´ de San Martı´n, Argentina, 3Universita` Degli Studi Di Parma, Italy, 4Indiana University, USA Disclosures: Xiaolin Tu, None

2:30 pm 1068

2011 ASBMR YOUNG INVESTIGATOR AWARD b-catenin Haploinsufficiency in Osteocytes Abolishes the Osteogenic Effect of Mechanical Loading In Vivo Behzad Javaheri*1, Mark Dallas1, Hong Zhao1, Lynda Bonewald1, Mark Johnson2. 1 University of Missouri - Kansas City, USA, 2University of Missouri, Kansas City Dental School, USA Disclosures: Behzad Javaheri, None

2:45 pm 1069

2011 ASBMR YOUNG INVESTIGATOR AWARD Treatment with Sclerostin Antibody Increases Bone Mass and Strength During Hindlimb Unloading Jordan Spatz*1, R Ellman2, AM Cloutier3, D Dwyer4, Marina Stolina5, HZ. Ke4, Mary Bouxsein 6. 1Harvard-MIT Division of Health Sciences & Technology (HST), USA, 2 Harvard-MIT Division of Health Sciences & Technology (HST), USA, 3Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, USA, 4Amgen Inc., USA, 5Amgen Inc, USA, 6Beth Israel Deaconess Medical Center, USA Disclosures: Jordan Spatz, None

3:00 pm 1070

Sclerostin Antibody Increased Bone Mass and Reduced Fractures in Osteogenesis Imperfecta Mice Jean-Pierre Devogelaer*1, Catherine Behets2, Patrick Ammann3, Michael Ominsky4, Christine Coppin2, Daniel H Manicourt2. 1St. Luc University Hospital, Belgium, 2 Universite´ catholique de Louvain, Belgium, 3Division of Bone Diseases, Switzerland, 4 Amgen, Incorporated, USA Disclosures: Jean-Pierre Devogelaer, None

3:15 pm 1071

Osteocyte-derived IGF-I Functions as a Portion of the Circuitry For Normal Loading Activation Response in Osteoblasts: Data From the Osteocyte IGF-I Conditional Knockout Mouse Matilda Sheng*1, Kin-Hing William Lau2, Xiaodong Zhou1, Lynda Bonewald3, David Baylink1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3University of Missouri - Kansas City, USA Disclosures: Matilda Sheng, None

3:30 pm 1072

Low Trabecular Bone Volume in a2C-Adrenoceptor Knockout Mice Marilia Teixeira*1, Gisele Martins2, Cristiane Costa 3, Patrı´cia Brum4, Cecı´lia Gouveia2. 1 University of Sao Paulo, Brazil, 2Institute of Biomedical Sciense, Brazil, 3Institute of Biomedical Science, Brazil, 4School of Physical Education an Sport, Brazil Disclosures: Marilia Teixeira, None

COFFEE BREAK 3:30 pm - 4:00 pm

Hall GH

CLINICAL UPDATE FOR HEALTH PROFESSIONALS 4:00 pm - 5:30 pm Co-Chairs Betsy C. McClung, R.N., M.N. Oregon Osteoporosis Center, USA Disclosures: Betsy McClung, None

Diane C. Krueger, CCRC, CDT University of Wisconsin, Madison, USA Disclosures: Diane Krueger, None

124

Room 20BCD

4:00 pm

Operationalizing Drug Holidays Michael R. McClung, M.D. Oregon Osteoporosis Center, USA Disclosures: Michael McClung, None

4:30 pm

New Strategies in the Management of Glucocorticoid Induced Osteoporosis Kenneth G. Saag, M.D., MSc University of Alabama at Birmingham, USA Disclosures: Kenneth Saag, Amgen 5; Eli Lilly 2; Eli Lilly 5; Novartis 2; Merck 2; Amgen 2; Merck 5; Novartis 5

5:00 pm

A Dental Perspective on Osteoporosis Therapy: New Applications and Long Term Risks Laurie K. McCauley, D.D.S., Ph.D. University of Michigan, School of Dentistry, USA Disclosures: Laurie McCauley, Amgen 1; Amgen 5

STATE-OF-THE-ART LECTURES – BONE-HEMATOPOIETIC INTERACTIONS Supported by an educational grant from Merck & Co., Inc. 4:00 pm - 5:30 pm

Room 20A

Co-Chairs Henry M. Kronenberg, M.D. Massachusetts General Hospital, USA Disclosures: Henry Kronenberg, Chugai 2; Novo/Nordisk 5; Novartis 5; Merck 5

Saturday

Laura M. Calvi, M.D. University of Rochester School of Medicine, USA Disclosures: Laura Calvi, None

4:00 pm

Multiple Myeloma John Shaughnessy Jr., Ph.D. University of Arkansas for Medical Sciences, USA Disclosures: John Shaughnessy, University of California San Francisco 9; MD Anderson 9; Signal Genetics 4; Genzyme 9; Novartis 7; Millennium 9; Novartis 9; Signal Genetics 1; International Myeloma Foundation - Roundtable 9; University of Tennessee-Memphis Cancer Foundation 9; Yale University 9; ArrayBiopharma 9; Celgene 9; Signal Genetics 7; J&J OrthoBiotech 9; Genzyme 7

4:30 pm

Overview of the Hematopoietic Niche, its Cellular Dynamics and Neuroendocrine Regulation Paul S. Frenette, M.D. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine, USA Disclosures: Paul Frenette, None

5:00 pm

Overview of Marrow B-cell Development and its Regulation by Osteoblast-dependent Gs-a Signaling Joy Y. Wu, M.D., Ph.D. Massachusetts General Hospital, USA Disclosures: Joy Wu, None

125

CLINICAL EVENING AT ASBMR Supported by Educational Grants from Amgen, Inc., Lilly USA, LLC., Merck & Co., Inc. Space is limited and available on a first-come, first-served basis. Attendees must be registered for the ASBMR 2011 Annual Meeting 5:30 pm - 8:30 pm

Manchester Grand Hyatt Randle Ballroom (4th Level)

Co-Chairs Shreyasee Amin, M.D., MPH Mayo Clinic, USA Disclosures: Shreyasee Amin, None

John Bilezikian, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: John Bilezikian, None

5:30 pm

Reception

6:30 pm

Dinner

7:00 pm

Where are we with FRAX in 2011? Eugene V. McCloskey, M.D., MRCP, M.B. University of Sheffield, United Kingdom Disclosures: Eugene McCloskey, Amgen 2; Amgen 5; Amgen 99

7:30 pm

Is There a Role for Combination Therapy for Osteoporosis? Felicia Cosman, M.D. Helen Hayes Hospital, USA Disclosures: Felicia Cosman, None

8:00 pm

The Role of Vertebroplasty or Kyphoplasty in the Management of Vertebral Fracture Patients Richard Eastell, M.D., FRCP University of Sheffield, United Kingdom Disclosures: Richard Eastell, Medtronics 5

ASBMR SOCIAL EVENT - CALIFORNIA DREAMIN’ Supported in part by a grant from Lilly USA, LLC 8:30 pm - 11:30 pm

Manchester Grand Hyatt Elizabeth Ballroom and Terrace (2nd Level)

What better way to catch up with current friends and meet new ones than with some drinks, some sweets, a little dancing and a lot of fun? Join us in the ballroom and on the outdoor terrace at the Manchester Grand Hyatt for an evening you won’t soon forget as we celebrate Southern California culture. As always, there will be a fabulous live dance band and a surprise or two to enliven the evening. Enjoy dinner at one of San Diego’s fabulous restaurants and then join us for dessert, drinks, music and networking. Tickets are $30.

126

Sunday, September 18, 2011

SUNDAY, SEPTEMBER 18, 2011 DAY-AT-A-GLANCE Time/Event/Location

All locations in the San Diego Convention Center unless otherwise noted

7:30 am - 5:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 ASBMR Registration Open Hall F 8:00 am - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Posters Open Hall GH 8:00 am - 9:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Gerald D. Aurbach Memorial Lecture - MicroRNA Control of Muscle Development and Disease Room 20BCD 9:00 am - 4:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Exhibits Open Hall GH 9:00 am - 9:05 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Presentation of the ASBMR Fuller Albright Award Room 20BCD 9:05 am - 9:10 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Presentation of the ASBMR Frederic C. Bartter Award Room 20BCD

9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Concurrent Oral Session 13: Bone - Hematopoietic Interactions Room 20A 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Concurrent Oral Session 14: Genetic Disorders of Bone and Mineral Metabolism Room 30CDE 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 Concurrent Oral Session 15: Cancer and Bone Room 32AB 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 Concurrent Oral Session 16: Osteoporosis Epidemiology: Fracture Risk in Specific Populations Room 20BCD 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135 Concurrent Oral Session 17: Disorders of Mineral Metabolism Room 29ABCD 9:30 am - 11:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 136 Concurrent Oral Session 18: Human Studies in Bone Biomechanics and Quality Room 31ABC 10:00 am - 11:00 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Meet-the-Professor Sessions Room 25A - Room 25C

127

Sunday

9:10 am - 9:30 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Coffee Break Hall GH

11:00 am - 1:00 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Poster Session II & Poster Tours Hall GH 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199 Meet-the-Professor Sessions Room 24A - Room 26B 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 Biotechniques Workshop: Mouse Models Room 29ABCD 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 Clinical Roundtable/Case Conference - Managing Musculoskeletal Disease in Chronic Renal Insufficiency Room 20BCD 1:00 pm - 2:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 Special Session: When a Reporter Calls: How to Communicate Your Research to the News Media Room 32AB 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 Concurrent Oral Session 19: Steroid Hormones and Receptors Room 20A 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 Concurrent Oral Session 20: Growth Factors, Cytokines, Immunomodulators Room 32AB 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 Concurrent Oral Session 21: TGF- b and Bone Physiology Room 29ABCD 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 Concurrent Oral Session 22: Methods of Osteoporosis Assessment Room 31ABC 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 Concurrent Oral Session 23: Osteoporosis Treatment (Clinical) Room 20BCD 2:15 pm - 3:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 Concurrent Oral Session 24: Childhood Factors with Bone Acquisition Room 30CDE 3:30 pm - 4:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 Coffee Break Hall GH 4:00 pm - 5:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 Clinical Update for Health Professionals – IOM Report on Vitamin D Room 20BCD 4:00 pm - 5:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 State-of-the-Art Lectures - TRP Channel Signaling In Skeletal Physiology and Mineral Metabolism Room 20A 5:30 pm - 6:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 ASBMR Town Hall Meeting and Reception Room 31ABC 6:30 pm - 9:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 ASBMR Women in Bone and Mineral Research Committee Event – Getting What You Want: The Art of Negotiation Room 25ABC Ticket Required

128

6:30 pm - 8:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208 Non-Invasive Assessment of Bone Microarchitecture and Function Working Group Room 30CDE Ticket Required 6:30 pm - 9:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209 Adult Bone and Mineral Working Group Room 30AB Ticket Required 6:30 pm - 9:20 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209 Vitamin D Working Group Room 32AB Ticket Required 6:30 pm - 9:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 Bone Strength Working Group Room 33ABC Ticket Required

Sunday 129

ASBMR REGISTRATION OPEN 7:30 am - 5:00 pm

Hall F

POSTERS OPEN 8:00 am - 6:00 pm

Hall GH

GERALD D. AURBACH MEMORIAL LECTURE - MICRORNA CONTROL OF MUSCLE DEVELOPMENT AND DISEASE 8:00 am - 9:00 am

Room 20BCD

Chair Dwight A. Towler, M.D., Ph.D. Washington University in St. Louis, USA Disclosures: Dwight Towler, None

8:00 am

MicroRNA Control of Muscle Development and Disease Eric N. Olson, Ph.D. UT Southwestern Medical Center At Dallas Department of Molecular Biology, USA Disclosures: Eric Olson, None

EXHIBITS OPEN 9:00 am - 4:00 pm

Hall GH

PRESENTATION OF THE ASBMR FULLER ALBRIGHT AWARD 9:00 am - 9:05 am

Room 20BCD

PRESENTATION OF THE ASBMR FREDERIC C. BARTTER AWARD 9:05 am - 9:10 am

Room 20BCD

COFFEE BREAK 9:10 am - 9:30 am

Hall GH

CONCURRENT ORAL SESSION 13: BONE - HEMATOPOIETIC INTERACTIONS 9:30 am - 11:00 am Moderators: Paolo Bianco, M.D. Universita La Sapienza, Italy Disclosures: Paolo Bianco, None

Moustapha Kassem, M.D., Ph.D. Odense University Hospital, Denmark Disclosures: Moustapha Kassem, None

130

Room 20A

9:30 am 1073

Bmp2 Gene in Osteoblasts Controls Bone Quantity and Quality by Regulating the Vascular Niche for Skeletal Stem Cells (SCCs) in both Periosteum and Trabeculae Wuchen Yang*1, Valentin David2, Jeffry Nyman3, Marie Harris1, Yong Cui 1, Jelica Gluhak-Heinrich1, Ivo Kalajzic4, Barbara Kream4, David Rowe4, Alexander Lichtler4, Xiao-Dong Chen1, Yuji Mishina5, Stephen Harris1. 1University of Texas Health Science Center At San Antonio, USA, 2UTHSC, USA, 3Vanderbilt University Medical Center, USA, 4University of Connecticut Health Center, USA, 5University of Michigan, USA Disclosures: Wuchen Yang, None

9:45 am 1074

Absence of NFATc2 Results In High Bone Mass and Impaired Hematopoiesis Martina Rauner*1, Wolfgang Bauer2, Ivonne Habermann2, Michael Haase3, Gerhard Ehninger2, Lorenz Hofbauer4, Alexander Kiani2. 1Medical Faculty of the TU Dresden, Germany, 2Technical University Dresden, Department of Medicine I, Germany, 3Technical University of Dresden, Institute of Pathology, Germany, 4Dresden Technical University Medical Center, Germany Disclosures: Martina Rauner, None

10:00 am Interleukin-6 Receptor Signaling Links Hematopoietic and Anabolic Actions of PTH in Bone 1075 Sun Wook Cho*1, Flavia Pirih 1, Megan Michalski1, Matt Eber1, Seo jin Oh1, Thomas Wronski2, Laurie McCauley3. 1University of Michigan School of Dentistry, USA, 2 University of Florida, USA, 3University of Michigan, School of Dentistry, USA Disclosures: Sun Wook Cho, None

10:15 am Circulating Human Lineage Negative/Osteoblast Progenitor Cells Support Hematopoiesis in 1076 Tk-Rag Mice Pilar Peris*1, Robert Jilka2, Sundeep Khosla3, Ulrike Moedder3. 1Hospital Clinic of Barcelona, Spain, 2University of Arkansas for Medical Sciences, USA, 3College of Medicine, Mayo Clinic, USA Disclosures: Pilar Peris, None

10:30 am Hematopoietic Stem Cells Give Rise to Osteo-chondrogenic Cells During Fracture Repair 1077 Meenal Mehrotra*, Jonathan D McGuirt, Christopher R williams, Makio Ogawa, Amanda C LaRue. Research Services, Ralph H Johnson VAMC & Medical University of South Carolina, USA Disclosures: Meenal Mehrotra, None

Disclosures: Xianmei Meng, None

CONCURRENT ORAL SESSION 14: GENETIC DISORDERS OF BONE AND MINERAL METABOLISM 9:30 am - 11:00 am

Room 30CDE

Moderators: Charles R. Farber, M.D. University of Virginia, USA Disclosures: Charles Farber, None

Brendan Lee, M.D., Ph.D. Baylor College of Medicine and Howard Hughes Medical Institute, USA Disclosures: Brendan Lee, None

9:30 am 1079

A Novel Syndrome Characterized By Intermittent Hypercalcemia, Hypercalciuria, Elevated Serum Calcitriol And Undectable 24,25-Dihyroxyvitamin D Concentrations, Nephrolithiasis, Osteoporosis, And Mutations in the CYP24A1 (25-Hydroxyvitamin D/1, 25Dihydroxyvitamin D 24-Hydroxylase) Gene Peter Tebben1, Dawn Milliner2, Ronald Horst3, Rajiv Kumar*4. 1Mercy Health, USA, 2 Mayo Clinic, USA, 3Heartland Assays, Inc., USA, 4Mayo Clinic College of Medicine, USA Disclosures: Rajiv Kumar, None

131

Sunday

10:45 am Transdifferentiation of Hematopoietic Stem Cells into Mesenchymal Stem Cells for Use in 1078 Bone Regeneration Xianmei Meng*1, Amanda Neises 1, Kin-Hing William Lau2, David Baylink1, Xiaobing Zhang1. 1Loma Linda University, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA

9:45 am 1080

Hajdu-Cheney Syndrome: Serum Biomarker Profiling, Bone Radiography and Histopathology, and Germline Mutation Analysis Indicate Complex Dysregulation of Skeletal Cells from Gain-of-Function Truncation of NOTCH2 Michael P. Whyte*1, Marina Stolina2, William H. McAlister3, Deborah Wenkert4, Deborah V. Novack5, Xiafang Zhang6, Angela R. Nenninger4, Denise C. Dwyer7, Vivienne T. Lim4, Nelson Watts8, David L. Lacey7, Steven Mumm1. 1Shriners Hospital for Children & Washington University School of Medicine, St. Louis, USA, 2Amgen Inc, USA, 3 Department of Pediatric Radiology at the Mallinckrodt Institute of Radiology, St Louis Childrens Hospital at the Washington University School of Medicine, St. Louis, USA, 4 Shriners Hospital for Children, St. Louis, USA, 5Washington University in St. Louis School of Medicine, USA, 6Washington University in St. Louis School of Medicine, St. Louis, USA, 7Amgen Inc., USA, 8University of Cincinnati Bone Health & Osteoporosis Center, USA Disclosures: Michael P. Whyte, Amgen, Inc, 5

10:00 am Paget’s Disease-causing Mutations in Sequestosome-1 Impair Autophagic Protein 1081 Degradation Eman Azzam, Miep Helfrich, Lynne Hocking*. University of Aberdeen, United Kingdom Disclosures: Lynne Hocking, None

10:15 am Mutations of SQSTM1 Cause Dysregulation of the Autophagy Pathway in Osteoclast 1082 Precursors and Are Responsible for Development of Intranuclear Inclusions in Paget’s Disease Anna Daroszewska1, Robert Van’t Hof1, Lorraine Rose 1, Ken Rose1, Rob Layfield2, Stuart Ralston*1. 1University of Edinburgh, United Kingdom, 2University of Nottingham, United Kingdom Disclosures: Stuart Ralston, None

10:30 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1083 Mutations in SERPINF1 cause Osteogenesis Imperfecta Type VI Erica Homan*1, Ingo Grafe2, Frank Rauch3, Caressa Lietman1, Jennifer Doll4, Brian Dawson1, Terry Bertin 1, Dobrawa Napierala5, Roy Morello 6, Richard Gibbs1, Lisa White1, Rika Miki7, Daniel Cohn7, Susan Crawford 4, Rose Travers3, Francis Glorieux8, Brendan Lee9. 1Baylor College of Medicine, USA, 2Department of Molecular & Human Genetics, Baylor College of Medicine, USA, 3Shriners Hospital for Children, Canada, 4 NorthShore University Health System Research Institute, USA, 5University of Alabama at Birmingham, School of Dentistry, USA, 6University of Arkansas for Medical Sciences, USA, 7University of California, Los Angeles, USA, 8Shriners Hospital for Children & McGill University, Canada, 9Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Erica Homan, None

132

Disclosures: Ling Oei, None

CONCURRENT ORAL SESSION 15: CANCER AND BONE 9:30 am - 11:00 am

Room 32AB

Moderators: Theresa A. Guise, M.D. Indiana University, USA Disclosures: Theresa Guise, None

Toshiyuki Yoneda, D.D.S., Ph.D. Osaka University Graduate School of Dentistry, Japan Disclosures: Toshiyuki Yoneda, None

9:30 am 1085

2011 ASBMR YOUNG INVESTIGATOR AWARD Activation of Notch Signaling in Bone Cells Causes Osteoma and Osteosarcoma Jianning Tao*1, Shan Chen1, Ming-ming Jiang 1, Yangjin Bae1, Terry Bertin 1, Francis Gannon1, Lisa Wang1, Lawrence Donehower1, Brendan Lee 2. 1Baylor College of Medicine, USA, 2Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Jianning Tao, None

133

Sunday

10:45 am Large-scale meta-analyses of Genome-Wide Association Studies for Fracture Risk: The 1084 GEFOS Consortium Ling Oei*1, Houfeng Zheng2, Evangelia Ntzani3, Karol Estrada4, Paul Ridker5, Melissa Garcia6, Yi-Hsiang Hsu7, Terho Lehtimaki8, Stella Trompet9, Stephen Kaptoge10, Scott Wilson11, Yongmei Liu12, Joel Eriksson13, Najaf Amin 14, Annie Kung15, Konstantinos Tsilidis3, Carolina Medina-Gomez 16, Lynda Rose5, Albert Vernon-Smith17, Ching-Ti Liu18, Jorma Viikari19, Alireza Moayyeri 20, Ryan Minster21, Mattias Lorentzon 22, Su-Mei Xiao23, Nicholas Wareham24, Ville Aalto25, Thor Aspelund26, William Leslie 27, David Goltzman28, Steven Cummings 29, L Cupples18, Evangelos Evangelou3, Kay-Tee Khaw20, Robert Luben20, Olli Raitakari25, Kristin Siggeirsdottir 30, Cornelia van Duijn14, Jane Cauley31, David Karasik32, Pak Sham23, M Zillikens33, Claes Ohlsson34, Tamara Harris35, Tim Spector36, Jonathan Reeve37, J Jukema9, John Ioannidis 3, Mika Kahonen38, Douglas Kiel32, Vilmundur Gudnason30, Andre Uitterlinden 39, Daniel Chasman5, Brent Richards 2, Fernando Rivadeneira4. 1Erasmus University Medical Center, The Netherlands, 2McGill University, Canada, 3University of Ioannina Medical School, Greece, 4Erasmus University Medical Center, The Netherlands, 5Brigham & Women’s Hospital, USA, 6NIA, NIH, USA, 7 Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 8 Department of Clinical Chemistry, University of Tampere & Tampere University Hospital, Finland, 9Leiden University Medical Center, Netherlands, 10University of Cambridge Bone Research Group, United Kingdom, 11Sir Charles Gardner Hospital, Australia, 12Wake Forest University School of Medicine, USA, 13Center for Bone & Arthritis Research, Institute of Medicin, Sahlgrenska Academy, University of Gothenburg, Sweden, Sweden, 14 Erasmus MC, Netherlands, 15Dr. Kung-Wai Chee Clinic, Hong Kong, 16Erasmus Medical Center, The Netherlands, 17Icelandic Heart Association & University of Iceland, Iceland, 18Boston University School of Public Health, USA, 19University of Turku & Turku University Hospital, Finland, 20University of Cambridge, United Kingdom, 21University of Pittsburgh, USA, 22Center for Bone Research at the Sahlgrenska Academy, Sweden, 23The University of Hong Kong, China, 24Medical Research Council (MRC), Epidemiology Unit, United Kingdom, 25Research Centre of Applied & Preventive Cardiovascular Medicine, University of Turku & the Department of Clinical Physiology, Finland, 26Icelandic Heart Association, Iceland, 27University of Manitoba, Canada, 28McGill University Health Centre, Canada, 29San Francisco Coordinating Center, USA, 30Icelandic Heart Association Research Institute, Iceland, 31University of Pittsburgh Graduate School of Public Health, USA, 32Hebrew SeniorLife, USA, 33Erasmus MC Rotterdam, The Netherlands, 34Centre for Bone & Arthritis Research, Sweden, 35Intramural Research Program, National Institute on Aging, USA, 36King’s College London, United Kingdom, 37Addenbrookes Hospital, United Kingdom, 38Department of Clinical Physiology, University of Tampere & Tampere University Hospital, Finland, 39Rm Ee 575, Genetic Laboratory, The Netherlands

9:45 am 1086

Hedgehog Signaling Modulates Osteoclast Formation and Bone Metastasis Michelle Hurchla*1, Emanuela Heller2, Kyu-Sang Jeong2, Marcos Vidal3, Jochen Schneider 4, Leah Goldberg2, Hongju Deng2, Mary C. Hornick2, Julie Prior 2, David Piwnica-Worms2, Fanxin Long5, Ross Cagen3, Katherine Weilbaecher 2. 1Washington University in St. Louis, USA, 2Washington University in St. Louis School of Medicine, USA, 3Mount Sinai School of Medicine, USA, 4Washu, USA, 5Washington University School of Medicine, USA Disclosures: Michelle Hurchla, None

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1087 New Players in the Tumor Bone Vicious Cycle: Myeloid Derived Suppressor Cells Enhance Bone Tumor Growth in Osteopetrotic PLCc2-/- Mice Aude-Helene CAPIETTO* 1, SEOKHO KIM 2, Roberta Faccio2. 1Washington University School of Medicine, USA, 2Washington University in St Louis School of Medicine, USA Disclosures: Aude-Helene CAPIETTO, None

10:15 am Parathyroid Hormone-related Peptide (PTHrP) Up-regulates Myeloid-Derived Suppressor 1088 Cells (MDSC) in the Bone Marrow, Contributing to Prostate Cancer Growth and Angiogenesis Serk In Park*1, William Sadler1, Amy Koh 1, Fabiana Soki1, Laurie McCauley 2. 1 University of Michigan, USA, 2University of Michigan, School of Dentistry, USA Disclosures: Serk In Park, None

10:30 am The Heparin Binding Domain of PRELP: a New Therapeutic Approach for the Treatment of 1089 Breast Cancer Induced Bone Metastases. Nadia Rucci*1, Mattia Capulli2, Barbara Peruzzi2, Anna Rufo2, Marta Capannolo 3, Barbara Peruzzi1, Dick Heinegard4, Anna Teti1. 1University of L’Aquila, Italy, 2 Department of Experimental Medicine, University of L’Aquila, Italy, 3Department of Experimental Medicine University of L’Aquila, Italy, 4Lund University, Sweden Disclosures: Nadia Rucci, None

10:45 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1090 ER Stress Signaling Molecule XBP1s Regulates Bone Marrow Stromal Cells in Multiple Myeloma Bone Disease Guoshuang Xu*1, Kai Liu1, Judy Anderson1, Suzanne Lentzsch1, G. David Roodman2, Hong-Jiao Ouyang1. 1University of Pittsburgh, USA, 2VA Pittsburgh Healthcare System (646), USA Disclosures: Guoshuang Xu, None

CONCURRENT ORAL SESSION 16: OSTEOPOROSIS EPIDEMIOLOGY: FRACTURE RISK IN SPECIFIC POPULATIONS 9:30 am - 11:00 am

Room 20BCD

Moderators: Kristine E. Ensrud, M.D., MPH Minneapolis VA Medical Center / University of Minnesota, USA Disclosures: Kristine Ensrud, None

Deborah E. Sellmeyer, M.D. The Johns Hopkins Bayview Medical Center, USA Disclosures: Deborah Sellmeyer, None

9:30 am 1091

FRAXH Underestimates Fracture Risk in Patients with Diabetes. Lora Giangregorio*1, William Leslie 2, Lisa Lix3, Helena Johansson4, Anders Oden5, Eugene McCloskey6, John Kanis7. 1University of Waterloo, Canada, 2University of Manitoba, Canada, 3University of Saskatchewan, Canada, 4Swedish University of Agricultural Sciences, The Biomedical Center, Sweden, 5Chalmers University of Technology, Sweden, 6University of Sheffield, United Kingdom, 7University of Sheffield, Belgium Disclosures: Lora Giangregorio, None

134

9:45 am 1092

2011 ASBMR YOUNG INVESTIGATOR AWARD Reduced Fracture Risk After Kidney Transplant With Early Corticosteroid Withdrawal Regimens: An Analysis of the United States Renal Data System Lucas Nikkel*1, Sumit Mohan1, Chiyuan Zhang2, Donald McMahon3, David Cohen1, Lloyd Ratner1, Geoffrey Dube1, Bekir Tanriover1, Christopher Hollenbeak4, Stephanie Boutroy5, Mary Leonard6, Elizabeth Shane3, Thomas Nickolas1. 1Columbia University Medical Center, USA, 2Columbia University, USA, 3Columbia University College of Physicians & Surgeons, USA, 4Penn State Hershey College of Medicine, USA, 5Columbia University Medical Center, New York, NY, USA, USA, 6Children’s Hospital of Philadelphia, USA Disclosures: Lucas Nikkel, Doris Duke Charitable Foundation, 2

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1093 Bone Resorption and Bone Mineral Density Across the Menopausal Transition in the Study of Women Across the Nation (SWAN) Beth Prairie*1, Leslie Meyn2, Kristine Ruppert2, Yinjuan Lian3, Carolyn Crandall4, Gail Greendale 4, Joel Finkelstein5, Mary Fran Sowers6, Jane Cauley7. 1University of Pittsburgh, Magee-Womens Hospital, USA, 2University of Pittsburgh, USA, 3University of Pittsburgh, USA, 4University of California, Los Angeles, USA, 5Massachusetts General Hospital, USA, 6University of Michigan, USA, 7University of Pittsburgh Graduate School of Public Health, USA Disclosures: Beth Prairie, None

10:15 am Trajectories of Femoral Neck Strength Over the Menopause Transition 1094 Shinya Ishii*1, Jane Cauley2, Carolyn Crandall1, Mei-Hua Huang3, Michelle Danielson4, Gail Greendale1, Arun Karlamangla 1. 1University of California, Los Angeles, USA, 2 University of Pittsburgh Graduate School of Public Health, USA, 3UCLA, USA, 4 University of Pittsburgh, USA Disclosures: Shinya Ishii, None

10:30 am Young and Elderly Women Matched for Areal BMD by DXA at the Radius Have Profound 1095 Differences in Cortical Porosity, but Not Trabecular Microstructure Kristy Nicks*1, Shreyasee Amin1, Elizabeth Atkinson1, Byron Riggs1, L. Joseph Melton1, Sundeep Khosla2. 1Mayo Clinic, USA, 2College of Medicine, Mayo Clinic, USA Disclosures: Kristy Nicks, None

Disclosures: Laura Yerges-Armstrong, None

CONCURRENT ORAL SESSION 17: DISORDERS OF MINERAL METABOLISM 9:30 am - 11:00 am

Room 29ABCD

Moderators: Elizabeth A. Streeten, M.D. University of Maryland School of Medicine, USA Disclosures: Elizabeth Streeten, None

Kenneth White, Ph.D. Indiana University School of Medicine, USA Disclosures: Kenneth White, None

9:30 am 1097

Treatment of Hypoparathyroidism with PTH(1-84) is Safe and Effective For Up to 4 Years Natalie Cusano*1, Mishaela Rubin2, Donald McMahon1, Rebecca Ives3, Jim Sliney Jr 3, John Bilezikian1. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University, USA, 3Columbia University Medical Center, USA Disclosures: Natalie Cusano, None

135

Sunday

10:45 am Differences in Hip Geometry Between Older Men With and Without Hip Fracture 1096 Laura Yerges-Armstrong*1, Marc Hochberg2, William Hawkes1, Lisa Reider3, Thomas Beck4, Denise Orwig 5, Jay Magaziner5. 1University of Maryland, USA, 2University of Maryland School of Medicine, USA, 3School of Public Health At Johns Hopkins, USA, 4 Quantum Medical Metrics, LLC, USA, 5University of Maryland, Baltimore, USA

9:45 am 1098

PTH(1-84) Replacement Therapy in Hypoparathyroidism (HypoPT): a Randomized Controlled Trial on Pharmacokinetics and Dynamic effects Following 24 Weeks of treatment Tanja Sikjaer*, Lars Rejnmark, Lars Rolighed, Leif Mosekilde. Aarhus University Hospital, Denmark Disclosures: Tanja Sikjaer, None

10:00 am Parathyroidectomy Improves Abnormal Cardiovascular Indices in Mild Primary 1099 Hyperparathyroidism Marcella Walker*1, Tatjana Rundek2, Shunichi Homma1, Marco DiTullio1, James A. Lee1, Chiuyan Zhang1, Donald J. McMahon 1, Ralph L. Sacco1, Shonni J. Silverberg1. 1Columbia University, USA, 2University of Miami, USA Disclosures: Marcella Walker, None

10:15 am Administration of Oral Bisphosphonates Prior to the Diagnosis of Breast Cancer is Associated 1100 with a Reduction in the Development of Skeletal Metastases Independent of Stage of Disease at Diagnosis Richard Kremer*1, Ari N. Meguerditchian 2, Bruno Gagnon2, Lyne Nadeau2, Nancy Mayo2. 1McGill University, Royal Victoria Hospital, Canada, 2McGill University Health Center, Canada Disclosures: Richard Kremer, Merck Frosst Canada, 8; Sanofi-Aventis, 8

10:30 am Hypogonadism in Men (HIM) and Hypogonadism with Estrogen Removal (HER): Effects of 1101 Androgens and Estrogens on Bone Resorption in Young Adult Men. Joel Finkelstein*1, Hang Lee 1, Elaine Yu1, Sherri-Ann Burnett-Bowie 1, J Carl Pallais 1, Benjamin Leder2. 1Massachusetts General Hospital, USA, 2Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Joel Finkelstein, Abbott, 99; AstraZeneca, 99

10:45 am Serum Sclerostin Levels Across a Wide Range of Bone Turnover 1102 Maria Yavropoulou*1, Antoon Van Lierop2, Neveen Hamdy2, Socrates Papapoulos 2. 1 Aristotle University of Thessaloniki, Greece, 2Leiden University Medical Center, The Netherlands Disclosures: Maria Yavropoulou, None

CONCURRENT ORAL SESSION 18: HUMAN STUDIES IN BONE BIOMECHANICS AND QUALITY 9:30 am - 11:00 am

Room 31ABC

Moderators: Heather McDonald-Blumer, M.D., FRCPC Mount Sinai Hospital, Canada Disclosures: Heather McDonald-Blumer, None

Mary L. Bouxsein, Ph.D. Beth Israel Deaconess Medical Center, USA Disclosures: Mary Bouxsein, None

9:30 am 1103

2011 ASBMR YOUNG INVESTIGATOR AWARD Non-collageneous Proteins Influence Bone Mineral Size, Shape and Orientation: A SAXS Study Atharva Poundarik*1, Caren Gundberg2, Deepak Vashishth3. 1Rensselaer Polytechnic University, USA, 2Yale University School of Medicine, USA, 3Rensselaer Polytechnic Institute, USA Disclosures: Atharva Poundarik, None

9:45 am 1104

Exercise When Young Provides Lifelong Benefit to Cortical Bone Structure and Strength in Men Sara Mantila Roosa*, Andrea Hurd, Robyn Fuchs, Stuart Warden. Indiana University, USA Disclosures: Sara Mantila Roosa, None

136

10:00 am Osteocyte Apoptosis is Required for Production of Pro-Osteoclastogenic Signals Following 1105 Bone Fatigue in vivo Oran Kennedy*1, Daniel Leong2, Herb Sun3, Robert Majeska4, Mitchell Schaffler5. 1The City College of New York, USA, 2City College New York, USA, 3Mount Sinai School of Medicine, USA, 4City College of New York, USA, 5City College of New York, USA Disclosures: Oran Kennedy, None

10:15 am The Adaptive Response of Cancellous Bone to In Vivo Loading Is Diminished in Adulthood: A 1106 Longitudinal Study Bettina Willie* 1, Annette Birkhold1, Marta Aido2, Tobias Thiele1, Alexander Schill1, Russell Main3, Georg Duda1. 1Charite´- Universita¨tsmedizin Berlin, Germany, 2Charite´Universita¨tsmedizin Berlin, Deu, 3Purdue University, USA Disclosures: Bettina Willie, None

10:30 am Bone Mineral Density (BMD) of Individual Trabeculae in Human Trabecular Bone 1107 Ji Wang*1, Bin Zhou1, X.Tony Shi1, Xiaowei Liu2, X Guo 1. 1Columbia University, USA, 2 Columbia University College of Physicians & Surgeons, USA Disclosures: Ji Wang, None

10:45 am How Vitamin D Deficiency Affects the Nature of Fracture Propagation in Human Bone 1108 Bjoern Busse*1, Hrishikesh Bale2, Elizabeth Zimmermann 3, Brian Panganiban2, Holly Barth2, Alessandra Carriero2, Michael Hahn4, Joel Ager2, Michael Amling 4, Robert Ritchie2. 1University of California - Berkeley, USA, 2University of California - Berkeley, Lawrence Berkeley National Laboratory, USA, 3University of California, Berkeley, USA, 4 University Medical Center Hamburg-Eppendorf, Germany Disclosures: Bjoern Busse, None

MEET-THE-PROFESSOR SESSIONS 10:00 am - 11:00 am

Rooms 25A-25C

Male Osteoporosis Room 25A Eric S. Orwoll, M.D. Oregon Health and Science University, USA Disclosures: Eric Orwoll, Eli Lilly 2

Sunday

Primary Hyperparathyroidism Room 25B John Bilezikian, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: John Bilezikian, None

Management of Skeletal Health in Women with Breast Cancer Room 25C Supported by an educational grant from Merck & Co., Inc. Meryl S. Leboff, M.D. Brigham and Women’s Hospital, USA Disclosures: Meryl Leboff, None

POSTER SESSION II & POSTER TOURS* 11:00 am - 1:00 pm

Hall GH

*Poster Tours will begin at the ASBMR Networking Center at 11:30 AM

AGING AND MUSCLE/BONE INTERACTIONS: CELLULAR AND MOLECULAR MECHANISMS SU0001

A Muscle Derived Soluble Factor Activates PI3K/b-catenin Signaling in Osteocytes Nuria Lara*1, Katharina Jaehn1, Sandra Romero-Suarez 1, Chenlin Mo 1, Lynda Bonewald1, Marco Brotto1, Mark Johnson2. 1University of Missouri - Kansas City, USA, 2 University of Missouri, Kansas City Dental School, USA Disclosures: Nuria Lara, None

137

SU0002

Age-related Decreases in Anti-oxidative response, Autophagy and Osteogenesis -Gene Profiles Studies Min Guan*1, Wei Yao2, Junjing Jia 2, Nancy Lane2. 1University of California, at Davis Medical Center, USA, 2University of California, Davis Medical Center, USA Disclosures: Min Guan, None

SU0003

Analysis of Lipid and Lipoprotein Metabolism of the Skeleton Using Nanocrystals Alexander Bartelt*1, Barbara Freund1, Harald Ittrich1, Joerg Heeren1, Andreas Niemeier1, Oliver T. Bruns2. 1University Medical Center Hamburg-Eppendorf, Germany, 2HeinrichPette-Institute for Experimental Virology & Immunology, Germany Disclosures: Alexander Bartelt, None

SU0004

Beta-ecdysone has Bone, Cartilage and Muscle Protective but no Estrogenic Effects in Ovariectomized Rats Dana Seidlova-Wuttke1, Wolfgang Wuttke*2. 1Robert-Koch-Str. 40, Germany, 2University of Goettingen, Germany Disclosures: Wolfgang Wuttke, None

SU0005

Role of SKI-1 Protease in Osteoblast/Osteocyte Formation and Maintenance of Bone and Body Mass Jeffrey Gorski*1, Nichole T. Huffman2, Annita Achilleos3, Paul A. Trainor3, Nabil G. Seidah4, Clifford Rosen5, Lynda Bonewald2. 1University of Missouri, Kansas City, School of Dentistry, USA, 2University of Missouri - Kansas City, USA, 3Stowers Institute for Medical Research, USA, 4Institut de Recherches Cliniques de Montreal, Canada, 5Maine Medical Center, USA Disclosures: Jeffrey Gorski, None

AGING AND MUSCLE/BONE INTERACTIONS: FRAILTY AND SARCOPENIA SU0006

Approaches to Enhancing Sarco-osteoporosis Identification in Older Adults Bjoern Buehring*1, Diane Krueger1, Neil Binkley2. 1University of Wisconsin, Madison, USA, 2University of Wisconsin, USA Disclosures: Bjoern Buehring, None

SU0007

Are the Institute of Medicine Vitamin D Guidelines "Sufficient" for Frail Long Term Care Residents? MaryAnn Ferchak*1, Megan Miller1, Carroll Lee1, Kimberly Zukowski1, Subashan Perera2, David Nace2, Neil Resnick2, Susan Greenspan3. 1University of Pittsburgh, Division of Endocrinology, USA, 2University of Pittsburgh, Division of Geriatrics, USA, 3 University of Pittsburgh, USA Disclosures: MaryAnn Ferchak, None

SU0008

Association of Spinal Muscle Composition and Prevalence of Hyperkyphosis In Healthy Community-Dwelling Older Men and Women Wendy Katzman*1, Peggy Cawthon2, Greg Hicks3, Eric Vittinghoff 4, John Shepherd4, Jane Cauley5, Tamara Harris6, Eleanor Simonsick7, Elsa Strotmeyer8, Catherine Womack9, Deborah Kado10. 1University of California San Francisco, USA, 2California Pacific Medical Center Research Institute, USA, 3University of Delaware, USA, 4University of California, San Francisco, USA, 5University of Pittsburgh Graduate School of Public Health, USA, 6Intramural Research Program, National Institute on Aging, USA, 7Clinical Research Branch, National Institute on Aging, USA, 8University of Pittsburgh, USA, 9 University of Tennessee, USA, 10University of California, Los Angeles, USA Disclosures: Wendy Katzman, None

SU0009

Effect of Vitamin D Supplementation on Cognitive Function in Older Adults with Mild Cognitive Impairment - A Randomized Trial Leon Flicker*1, Kathryn Greenop2, Osvaldo Almeida3, Helman Alfonso3, Christopher Beer3, Keith Hill 4, Caryl Nowson5, Samuel Vasikaran6, Nicola Lautenschlager7. 1 University of Western Australia, Australia, 2Telethon Institute for Child Health Research, Australia, 3Western Australian Centre for Health & Ageing, Australia, 4Latrobe University, Australia, 5Deakin University, Australia, 6Department of Core Clinical Pathology & Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Australia, 7 Department of Psychiatry, University of Melbourne, Australia Disclosures: Leon Flicker, None

138

SU0010

Osteoporosis and Spinal Cord Injury in Patient with Ankylosing Spondylitis Hyun-Sook Kim*. Chosun University Hospital, South Korea Disclosures: Hyun-Sook Kim, None

SU0011

Prevalence of Sarcopenia and Osteopenia among 70-80-year Old Finnish Women Kirsti Uusi-Rasi*, Pekka Kannus, Saija Karinkanta, Matti Pasanen, Radhika Patil, Harri Sieva¨nen. UKK Institute for Health Promotion Research, Finland Disclosures: Kirsti Uusi-Rasi, None

SU0012

Prevalence of Sarcopenia in Older Men: The Geelong Osteoporosis Study Julie Pasco*1, Margaret J Henry1, Mark Kotowicz2, Geoff C Nicholson3. 1Deakin University, Australia, 2Barwon Health, Australia, 3The University of Queensland, Australia Disclosures: Julie Pasco, Speaker fees from Eli Lilly, Amgen, Sanofi Aventis, 8; NHMRC grants 454356 and 628582, 2

SU0013

The Association of Sarco-Osteopenia With Health Related Quality of Life: A PopulationBased Study In Estonia Mart Kull*1, Riina Kallikorm2, Margus Lember 2. 1University of Tartu, Department of Internal Medicine, Estonia, 2University of Tartu, Estonia Disclosures: Mart Kull, None

SU0014

The Association of Sarcopenia and Sarcopenic-Obesity with Mobility Limitations in Older Men and Women: The Framingham Study Alyssa Dufour*1, Marian Hannan2, Joanne Murabito3, Douglas Kiel1, Robert McLean4. 1 Hebrew SeniorLife, USA, 2HSL Institute for Aging Research & Harvard Medical School, USA, 3Boston University School of Medicine & NHLBI’s Framingham Heart Study, USA, 4 Hebrew SeniorLife, Harvard Medical School, USA Disclosures: Alyssa Dufour, None

AGING AND MUSCLE/BONE INTERACTIONS: REHABILITATION AND EXERCISE SU0015

Higher Premenarcheal Bone Mass in Elite Gymnasts is Maintained into Young Adulthood After Long-Term Retirement From Sport: A 14-year Follow-Up Marta Erlandson*1, Saija Kontulainen2, Phil Chilibeck2, Cathy Arnold3, Bob Faulkner2, Adam Baxter-Jones2. 1University of Toronto, Canada, 2University of Saskatchewan, Canada, 3Unviersity of Saskatchewan, Canada

SU0016

Sunday

Disclosures: Marta Erlandson, None

The Development of Neuromuscular Function in Pre-school Aged Children Tom Hazell*1, Sarah Finch1, Thu Trang Pham1, Sonia Jean-Philippe1, Catherine A. Vanstone 1, Sandra Dell’Elce1, Atul K. Sharma2, Hope Weiler1, Celia Rodd1. 1McGill University, Canada, 2Montreal Children’s Hospital, Canada Disclosures: Tom Hazell, None

SU0017

Use of the Safe Functional Motion-Short Form Test to Classify Risk in Individuals Following a Distal Radius Fracture Norma MacIntyre* 1, Joy C. MacDermid 1, Ruby Grewal2, Julie Richardson1. 1McMaster University, Canada, 2Hand & Upper Limb Centre, St Joseph’s Health Centre, Canada Disclosures: Norma MacIntyre, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: ASSESSMENT OF PEDIATRIC BONE DISEASE SU0018

Assessment of Bone Mineral Status in Children with Noonan Syndrome: Another Consequence of Dysregulated RAS-MAPK Signaling? Monica Grover*1, Kiran Choudhry1, Alyssa Tran1, Susan Carter1, E. O’ Brian Smith1, Kenneth Ellis 1, Brendan Lee2. 1Baylor College of Medicine, USA, 2Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Monica Grover, None

SU0019

The Effect of Obesity on Pediatric Fractures Rushyuan J. Lee*1, Colleen Cullen 1, Josephina Baca-Asher1, Meredith Lazar-Antman1, Arabella Leet 2. 1Johns Hopkins University, USA, 2Johns Hopkins University School of Medicine, USA Disclosures: Rushyuan J. Lee, None

139

SU0020

Youth School Physical Education Grades and Tibial Bone Traits in Adulthood Vera Mikkila¨1, Marika Laaksonen1, Olli Raitakari2, Sanna Tolonen*3, Harri Sieva¨nen 4, Terho Lehtima¨ki 5, Mika Ka¨ho¨nen6, Jorma Viikari7. 1University of Helsinki, Finland, 2 Turku University Hospital & Research Centre of Applied & Preventive Cardiovascular Medicine, Finland, 3Master in Health Sciences (Nutrition), Finland, 4UKK Institute, Finland, 5Medical School & Tampere University Hospital, Finland, 6Tampere University Hospital, Finland, 7Turku University Central Hospital, Finland Disclosures: Sanna Tolonen, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: BONE ACQUISITION SU0021

A Comparison of Trabecular Bone Microstructure at the Distal Radius Between Postpubertal Asian and Caucasian Adolescents: An HR-pQCT Study SoJung Kim* 1, Lindsay Nettlefold1, Christa Hoy1, Sarah Moore1, Meghan Donaldson2, Heather Macdonald 1, Heather McKay1. 1University of British Columbia, Canada, 2San Francisco Coordinating Center, USA Disclosures: SoJung Kim, None

SU0022

Negligible Influence of Vitamin D Status On Cortical Bone Development In Childhood: Findings From A Large Prospective Cohort Study Adrian Sayers*1, Debbie Lawlor1, William Fraser 2, J.H. Tobias3. 1University of Bristol, United Kingdom, 2Royal Liverpool University Hospital, United Kingdom, 3Avon Orthopaedic Centre, United Kingdom Disclosures: Adrian Sayers, None

SU0023

Non-Elite Gymnastics Induces Musculoskeletal Benefits in the Upper Limbs of Early Pubertal Girls: A 6-Month Study Using pQCT Lauren Burt*1, David Greene 2, Geraldine Naughton2, Daniel Courteix3, Gaele Ducher4. 1 Centre of Physical Activity Across the Lifespan, Australian Catholic University, Australia, 2 Centre of Physical Activity Across the Lifespan, School of Exercise Science, Australian Catholic University, Australia, 3Universite Clermont Ferrand Laboratoire De Biologie Des APS, France, 4Noll Laboratory, Department of Kinesiology, Penn State University, USA Disclosures: Lauren Burt, None

SU0024

Optimizing Low-Magnitude, High-Frequency Vibration Parameters to Stimulate an Osteogenic Response in the mdx Mouse Model of Duchenne Muscular Dystrophy Susan Novotny*1, David J. Nuckley1, Moira Petit1, Kristen A. Baltgalvis1, Gordon L. Warren2, Dawn A Lowe 1. 1UNIVERSITY OF MINNESOTA, USA, 2Georgia State University, USA Disclosures: Susan Novotny, None

SU0025

Racial Differences in Cortical Bone Mass, Size and Estimated Strength at the Tibial Diaphysis in Early Pubertal Children Stuart Warden*1, Ashley Ferira2, Emma Laing3, Kathleen Hill 4, Berdine Martin5, Connie Weaver5, Munro Peacock6, Richard Lewis3. 1Indiana University, USA, 2University of Georgia, USA, 3The University of Georgia, USA, 4Indiana University School of Medicine, USA, 5Purdue University, USA, 6Indiana University Medical Center, USA Disclosures: Stuart Warden, Eli Lilly, 5

SU0026

Sex Specific Effects of Physical Activity on Proximal Femur BMD in 8-9 Years Children Grac¸a Cardadeiro1, Fatima Baptista*1, Rui Ornelas2, Luı´s B. Sardinha 1. 1Exercise & Health Laboratory, Faculty of Human Movement, TU Lisbon, Portugal, 2 Madeira University, Portugal Disclosures: Fatima Baptista, None

SU0027

Vitamin D Insufficiency and Bone Mineral Status in Newcomer Immigrant and Refugee Children to Canada, an Emerging Public Health Problem Hassanali Vatanparast*1, Christine Nisbet2. 1University of Saskatchewan, Canada, 2 Univeristy of Saskatchewan, Canada Disclosures: Hassanali Vatanparast, None

140

SU0028

Zinc Supplementation Improves Bone Formation in Early Pubertal Females Richard Lewis*1, Norman Pollock2, Emma Laing1, Paul Bernard3, Arthur Grider1, Sue Shapses4, Kehong Ding2, Carlos Isales3. 1The University of Georgia, USA, 2Georgia Health Sciences University, USA, 3Medical College of Georgia, USA, 4Rutgers University, USA Disclosures: Richard Lewis, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: PATHOPHYSIOLOGY OF PEDIATRIC BONE DISEASE SU0029

Bioavailability of Vitamin D in Adolescents with Anorexia Nervosa Amy DiVasta*1, Michael Holick2, Catherine Gordon3. 1Children’s Hospital Boston, USA, 2 Boston University School of Medicine, USA, 3Children’s Hospital Boston & Harvard Medical School, USA Disclosures: Amy DiVasta, None

SU0030

Leptin-directed Osteocalcin Regulation is Influenced by Health and Gender in Adolescents with Type 1 Diabetes Shannon Haley1, Mary Murray2, Laurie Moyer-Mileur*2, Kenny Helmandollar2, Hillarie Slater2, Kristine Jordan2. 1University of Utah School of Medicine, USA, 2University of Utah, USA Disclosures: Laurie Moyer-Mileur, None

SU0031

The Interaction of Maternal Obesity and Neonatal Vitamin D Deficiency on Neonatal Anthropometrics Jami Josefson*1, Heather Price2, Alfred Rademaker1, Dinah Zeiss 1, Craig Langman2. 1 Northwestern University, USA, 2Children’s Memorial Hospital, USA Disclosures: Jami Josefson, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: TREATMENT OF PEDIATRIC BONE DISEASE SU0032

Disclosures: Michael P. Whyte, Enobia Pharma, Inc, 2; Enobia Pharma, Inc, 5

BONE BIOMECHANICS AND QUALITY: ASSESSMENT OF BONE QUALITY AND STRENGTH SU0033

Accuracy of Histomorphometric Parameters to Quantify Trabecular Architecture: Comparison of 2D Thin Sections with 3D mCT Data Oleg Museyko1, Robert Percy Marchall2, Jing Lu1, Georg Schett3, Michael Amling 2, Klaus Engelke*1. 1University of Erlangen, Germany, 2University Medical Center HamburgEppendorf, Germany, 3Friedrich-Alexander University Medical School, France Disclosures: Klaus Engelke, None

SU0034

Age and Gender Differences in Tibia Morphology and Estimated Bone Strength in Caucasians Using Serial pQCT Scans Vanessa Sherk*, Debra Bemben. University of Oklahoma, USA Disclosures: Vanessa Sherk, None

141

Sunday

Hypophosphatasia (HPP): Iliac Crest Histomorphometry of Affected Children Given Subcutaneous Enzyme Replacement Therapy, ENB-0040 Michael P. Whyte*1, Katherine L. Madson2, Amy L. Reeves2, Deborah Wenkert2, Cheryl R. Greenberg3, Nerissa Kreher4, Hal Landy4, Frank Rauch5, Francis Glorieux6. 1Shriners Hospital for Children & Washington University School of Medicine, St. Louis, USA, 2 Shriners Hospital for Children, St. Louis, USA, 3University of Manitoba, Canada, 4 Enobia Pharma, Inc, USA, 5Shriners Hospital for Children, Canada, 6Shriners Hospital for Children & McGill University, Canada

SU0035

Anatomically Confined Alterations in Collagen Cross-Links Coupled with Structural Changes Influence the Mechanical Properties of Whole Bone Independently of the Amount and Quality of Bone Mineral Eleftherios Paschalis* 1, Dimitris Tatakis2, Simon Robins3, Peter Fratzl4, Inderchad Manjubala4, Ruth Zoehrer1, Sonja Gamsjaeger 1, Birgit Buchinger1, Andreas Roschger 1, Roger Phipps5, Enrico Dall’Ara6, Peter Varga7, Philippe Zysset6, Klaus Klaushofer1, Paul Roschger 1. 1Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Austria, 2 Division of Periodontology, The Ohio State University, USA, 3Rowett Institute, United Kingdom, 4Max Planck Institute of Colloids & Interfaces, Department of Biomaterials, Research Campus Golm, Germany, 5Husson University School of Pharmacy, USA, 6 Vienna University of Technology, Austria, 7Institut fu¨r Leichtbau und StrukturBiomechanik, TU, Austria Disclosures: Eleftherios Paschalis, None

SU0036

Association Between Prevalent Vertebral Fracture and Lumbar Vertebral Bone Density, Morphology, Geometry, and Compressive Strength in Men and Women: the Framingham QCT Study Yoo Mee Kim*1, Serkalem Demissie2, Qiong Louie-Gao2, Elizabeth Samelson3, Douglas Kiel4, Mary Bouxsein5. 1Department of Internal Medicine, MizMedi Hospital, South Korea, 2Deparment of Biostatistics, Boston University School of Public Health, USA, 3 Hebrew SeniorLife, Harvard Medical School, USA, 4Hebrew SeniorLife, USA, 5Beth Israel Deaconess Medical Center, USA Disclosures: Yoo Mee Kim, None

SU0037

Bone Microarchitecture and Finite Element Analysis Measured with HR-pQCT can Identify Postmenopausal Women with and Without Forearm Fragility Fractures Kyle Nishiyama*1, Heather Macdonald 2, David Hanley1, Steven Boyd1. 1University of Calgary, Canada, 2University of British Columbia, Canada Disclosures: Kyle Nishiyama, None

SU0038

Bone Tissue Quality Determination Using Novel Reference Point Indentation Technique Oran Kennedy*1, Matin Lendhey2, Davis Brimer3, Robert Majeska4, Mitchell Schaffler5. 1 The City College of New York, USA, 2City College New York, USA, 3Active Life Scientific, Inc., USA, 4City College of New York, USA, 5City College of New York, USA Disclosures: Oran Kennedy, None

SU0039

Calcium Phosphate Glass/Collagen: Preparation and Properties Yu Zhang, Ning Jiang*, Racquel LeGeros. New York University College of Dentistry, USA Disclosures: Ning Jiang, None

SU0040

Cell Based Gene Therapy for Fracture Healing on a Rat Femural Critical Size Defect Corinne Sonnet*1, Ronke Olabisi2, Kayleigh Sullivan1, LaShan Simpson2, John Hipp1, ZaWaunyka Lazard1, Zbigniew Gugala3, Francis Gannon1, Steve Stice4, John Peroni4, Michael Weh4, Eva Sevick5, Michael Heggeness1, Alan Davis1, Jennifer West2, Elizabeth Olmsted-Davis1. 1Baylor College of Medicine, USA, 2Rice University, USA, 3University of Texas Medical Branch, USA, 4University of Georgia, USA, 5University of Texas, USA Disclosures: Corinne Sonnet, None

SU0041

Changes in Human Vertebral Bone Microstructure from Infancy to Senescence Jesper Thomsen*1, Annemarie Bru¨el 1, Ellen Hauge2. 1University of Aarhus, Denmark, 2 Aarhus University Hospital, Denmark Disclosures: Jesper Thomsen, None

SU0042

Changes of Mechanical Properties of Lumbar Vertebrae in Ovariectomized Rats ZhiQi Peng*, Jukka P. Rissanen, Jukka Va¨a¨ra¨niemi, Heikki Vuorikoski, Jussi Halleen, Jukka Morko. Pharmatest Services Ltd, Finland Disclosures: ZhiQi Peng, Pharmatest Services Ltd, 3

142

SU0043

Differences in Skeletal Micro-architecture in African-American and Caucasian Women Melissa Putman* 1, Elaine Yu2, Elizabeth Schindler2, Alexander Taylor2, Emily Cheston2, Mary Bouxsein3, Robert Neer2, Joel Finkelstein 2. 1Massachusetts General Hospital, Children’s Hospital Boston, USA, 2Massachusetts General Hospital, USA, 3Beth Israel Deaconess Medical Center, USA Disclosures: Melissa Putman, None

SU0044

Effect of a High-Fat Diet on Bone Strain in Adult Rat Femurs Cheryl Druchok*, Andrew Don-Wauchope, Alison Holloway, Gregory Wohl. McMaster University, Canada Disclosures: Cheryl Druchok, None

SU0045

Effects of Cyclical Treatments with PTH and Alendronate on Trabecular Bone Mass and Strength Sarah Amugongo*1, Wei Yao2, Junjing Jia 3, Daniel Walsh4, Mohammad Shahnazari 5, Brian Panganiban6, Robert Ritchie6, Min Guan7, Chin-Shang Li8, Nancy Lane2. 1 University of California, Davis, USA, 2University of California, Davis Medical Center, USA, 3UCDavis, USA, 4UC Davis Medical Center, USA, 5UCSF VA Medical Center, USA, 6University of California Berkeley, USA, 7University of California, at Davis Medical Center, USA, 8UC Davis, USA Disclosures: Sarah Amugongo, None

SU0046

Evaluation of QCT Cortical Hip Parameters in a Clinical Trial with Rosiglitazone: The Potential for a New Study Endpoint? Colin G. Miller*1, Antonio J. Nino2, John P. Bilezikian3, Barbara Kravitz2, Gitanjali Paul2, Alexander R. Cobitz2, Allison R. Northcutt2, Lorraine A. Fitzpatrick2. 1Bioclinica, USA, 2 GlaxoSmithKline Pharmaceuticals, USA, 3Columbia University, College of Physicians & Surgeons, USA Disclosures: Colin G. Miller, GlaxoSmithKline Pharmaceuticals, 5

SU0047

Fibula Osteotomy Model in the Sprague-Dawley Rat: Radiology, Densitometry, Biomechanics and histological characterization Aurore Varela*1, Luc Chouinard 2, Yannick Trudel3, CAROLINE RUH 3, Iryna Primakova3, Gabrielle Boyd3, Katherine Escott4, Susan Y. Smith1. 1Charles River Laboratories, Canada, 2Charles River Laboratories, PCS Montreal, Canada, 3Charles River, Canada, 4Astrazeneca R&D, United Kingdom

SU0048

Fracture Risk Classifiers based on Statistical Shape and Density Modeling of the Proximal Femur Todd Bredbenner* 1, Robert L. Mason1, Lorena M. Havill2, Eric Orwoll3, Daniel P. Nicolella1. 1Southwest Research Institute, USA, 2Texas Biomedical Research Institute, USA, 3Oregon Health & Science University, USA Disclosures: Todd Bredbenner, None

SU0049

How Tough is Brittle Osteogenesis Imperfecta Mice Bone? Alessandra Carriero*1, Elizabeth Zimmermann 2, Bjoern Busse3, Sandra J. Shefelbine1, Robert O. Ritchie4. 1Imperial College London, United Kingdom, 2University of California, Berkeley, USA, 3University of California - Berkeley, USA, 4University of California Berkeley, USA Disclosures: Alessandra Carriero, None

SU0050

Image Quality Control for the Detection of Subject Motion in HR-pQCT Yves Pauchard* 1, Anna-Maria Liphardt 1, Eva Szabo2, Heather Macdonald 3, David Hanley1, Steven Boyd1. 1University of Calgary, Canada, 2Roger Jackson Center for Health & Wellness Research, University of Calgary, Canada, 3University of British Columbia, Canada Disclosures: Yves Pauchard, None

143

Sunday

Disclosures: Aurore Varela, None

SU0051

Influence of Model Parameters in Large Scale Finite Element Simulations When Evaluating Stress Field in Human Trabecular Bone Baptiste Depalle*1, Roland Chapurlat2, Benyebka Bou-Said3, Helene Follet4. 1INSERM, UMR 1033 ; Universite de Lyon, France, 2E. Herriot Hospital, France, 3Universite´ de Lyon, CNRS, INSA-Lyon, LaMCoS UMR5259, France, 4INSERM, UMR 1033 ; Universite de Lyon, Fra Disclosures: Baptiste Depalle, None

SU0052

Modeling the Load Capacity of the Proximal Femur Joyce Keyak*1, Thomas Lang2. 1University of California, USA, 2University of California, San Francisco, USA Disclosures: Joyce Keyak, None

SU0053

N-acetyl Cysteine Supplementation Mitigates Deterioration of Bone Microstructure in Mice Fed a High-Fat Diet Brian Gregoire1, Jay Cao*2. 1USDA ARS Grand Forks Human Nutrition Research Center, USA, 2USDA ARS, USA Disclosures: Jay Cao, None

SU0054

Non-invasive Quantification of Changes in Bone Micro-architecture and Strength: Three Year Follow-up at the Distal Radius Ingrid Knippels*1, L. Joseph Melton2, Shreyasee Amin2, Steven Boonen3, Sundeep Khosla4, Harry Van Lenthe5. 1KULeuven, Belgium, 2Mayo Clinic, USA, 3Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 4College of Medicine, Mayo Clinic, USA, 5Katholieke Universiteit Leuven, Belgium Disclosures: Ingrid Knippels, None

SU0055

Paired Bone Biopsies - How Valid Are They? A Prospective Controlled Study! Doris. Wagner1, Hans Peter Dimai 2, Karin Amrein3, Thomas Pieber2, Harald Dobnig4, Philipp Stiegler1, Michael Sereinigg1, Christine Beham.Schmid 5, Astrid FahrleitnerPammer* 6. 1Division for Transplantation, Department of Surgery, Medical University of Graz, Austria, 2Division of Endocrinology & Metabolim, Department of Internal medicine, Austria, 3Medical University of Graz, Austria, 4Diagnostikinstitut Dr.B.Fueger, Institute for Endocrine & Bone Diseases, Aut, 5Department of Pathology, Austria, 6Medical University Graz, Austria Disclosures: Astrid Fahrleitner-Pammer, None

SU0056

Prediction of Apparent Modulus, Ultimate Stress and Ultimate Strain of Human Vertebrae using a Viscous Damage Model with Softening Jakob Schwiedrzik*, Enrico Dall’Ara, Philippe Zysset. Vienna University of Technology, Austria Disclosures: Jakob Schwiedrzik, None

SU0057

Prediction of Forearm Failure Load in Women: the OFELY Study Nicolas Vilayphiou*1, Stephanie Boutroy1, Elisabeth Sornay-Rendu1, Bert van Rietbergen 2, Roland Chapurlat1. 1INSERM UMR1033, Universite´ de Lyon & Hospices Civils de Lyon, France, 2Department of Biomedical Engineering, Eindhoven University of Technology, Netherlands Disclosures: Nicolas Vilayphiou, None

SU0058

Radius and Tibia Strength Assessed by High Resolution pQCT Micro Finite Element Analysis: Effects of Age and Gender Jennifer Walsh*1, Margaret Paggiosi2, Richard Eastell3. 1NIHR Bone Biomedical Research Unit, United Kingdom, 2Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom, 3University of Sheffield, United Kingdom Disclosures: Jennifer Walsh, None

SU0059

Role of Glycation in Microdamage Morphology in Cancellous and Cortical Bone Lamya Karim*, Deepak Vashishth. Rensselaer Polytechnic Institute, USA Disclosures: Lamya Karim, NIH-NIGMS T32GM067545, 2

144

SU0060

The Ability of Quantitative Ultrasound in Predicting the Principal Structural Orientation of Trabecular Bone Liangjun Lin*1, Christopher Lin 2, Frederick Serra-Hsu3, Jiqi Cheng1, Yi-Xian Qin1. 1State University of New York at Stony Brook, USA, 2Ward Melville High School, USA, 3State University of New York, Stony Brook, USA Disclosures: Liangjun Lin, None

BONE BIOMECHANICS AND QUALITY: CHANGES IN BONE QUALITY IN UNTREATED AND TREATED OSTEOPOROSIS SU0061

Modulation of Bone’s Mechanical Properties by its Architecture, Chemical Composition, and Age Andrea Trinward*1, Steven Tommasini1, Alvin Acerbo2, Lisa Miller3, Stefan Judex1. 1 Stony Brook University, USA, 2Brookhaven National Laboratody, USA, 3Brookhaven National Laboratory, USA Disclosures: Andrea Trinward, None

SU0062

Short-term Parathyroid Hormone Treatment Improves Cortical Bone Microstructure Maria-Grazia Ascenzi*1, Vivian Liao 1, Brittany Lee 1, Robert Lindsay2, Felicia Cosman2, Jeri Nieves 3, John Bilezikian4, David Dempster 3. 1University of California, Los Angeles, USA, 2Helen Hayes Hospital, USA, 3Columbia University, USA, 4Columbia University College of Physicians & Surgeons, USA Disclosures: Maria-Grazia Ascenzi, Micro-Genarated Algorithms, 99

SU0063

The Effect of Zoledronic Acid on Cancellous and Cortical Bone Matrix Mineralization in Postmenopausal Osteoporotic Patients Paul Roschger*1, Barbara Misof1, Daniela Gabriel1, Eleftherios Paschalis1, Erik Eriksen2, Juerg Gasser3, Klaus Klaushofer1. 1Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria, 2Hormonlaboratoriet, AUS Aker Universitetssykehus Trondheimsveien, Oslo, Norway, 3Novartis Institutes for BioMedical Research, Basel, Switzerland Disclosures: Paul Roschger, None

SU0064

Disclosures: Xiao Yang, None

BONE BIOMECHANICS AND QUALITY: DISUSE OSTEOPOROSIS SU0065

Differences in Tibia Morphology Between the Lower Limbs of AFO-using Survivors of Stroke Kyle Sherk*1, Vanessa Sherk1, Mark Anderson 2, Debra Bemben 1, Michael Bemben1. 1 University of Oklahoma, USA, 2University of Oklahoma Health Sciences Center, USA Disclosures: Kyle Sherk, None

SU0066

Evaluation of HR-pQCT in Non-human Primates for Monitoring the Effect of Odanacatib on Bone Microarchitecture. Richa Jayakar*1, Antonio Cabal1, John Szumiloski1, Swanand Sardesai1, Eual Phillips2, Christopher Winkelmann1, Paul McCracken3, Thomas Hangartner4, DON WILLIAMS5. 1 Merck & Co., Inc., USA, 2University of Pennsylvania, USA, 3Merck Research Laboratories, USA, 4Wright State University, USA, 5MERCK, USA Disclosures: Richa Jayakar, Merck, 3; Merck, 1

SU0067

In Vivo Mesenchymal Stem Cell Proliferation Promoted by Dynamic Fluid Flow Stimulation Minyi Hu*1, Robbin Yeh1, Michelle Lien 1, Yi-Xian Qin2. 1Stony Brook University, USA, 2 State University of New York at Stony Brook, USA Disclosures: Minyi Hu, None

145

Sunday

Viscoelastic Response of PTH, Ibandronate and Combination Treatment in Ovariectomized Rat Femur Correlating with BMD Xiao Yang*, Yong Hoow Chan, PADMALOSINI MUTHUKUMARAN, Taeyong Lee. NATIONAL UNIVERSITY OF SINGAPORE, Singapore

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING CELLULAR AND MOLECULAR EFFECTS SU0068

Bone Mass And Microarchitecture Changes In Subchondral Bone During Osteoarthritis: Influence of Prior Mechanical Loading? Arnaud Boudenot*1, Stephane Pallu2, Nathalie Presle3, Christelle Jaffre´4, Claude Laurent Benhamou 5. 1Inserm Unit U658, Hopital Porte Madeleine, Orle´ans, France, France, 2 INSERM U 658 / University of Orle´ans, France, 3UMR CNRS-UHP 7561, France, 4 INSERM U658, Caracte´risation du Tissu Osseux par Imagerie : Techniques et applications, France, 5INSERM Orle´ans-France, France Disclosures: Arnaud Boudenot, None

SU0069

Effects of Pulsed Electromagnetic Field Stimulation on Transient Gene Expression Related to Bone Formation in Old Rats Hiroyuki Tamaki*1, Atsumu Yuki2, Kounosuke Tomori3, kengo Yotani4, Hikari Kirimoto 1, Hideaki Onishi 1, Norikatsu Kasuga2. 1Niigata University of Health & Welfare, Japan, 2Aichi University of Education, Japan, 3Kanagawa University of Human Services, Japan, 4National Institute of Fitness & Sports, Japan Disclosures: Hiroyuki Tamaki, None

SU0070

Fluid Flow Induced Early Response Genes Are Selectively Altered by Age Leah Worton* 1, Ronald Kwon 2, Edith Gardiner3, Ted Gross 3, Sundar Srinivasan3. 1The University of Washington, USA, 2La Jolla Bioengineering Institute, USA, 3University of Washington, USA Disclosures: Leah Worton, None

SU0071

Impact of Deleting the IGF-1 Receptor in Mature Osteoblasts on the Skeletal Response to Unloading and Reloading Takuo Kubota*1, Hashem Elalieh1, Muriel Babey1, Yongmei Wang1, Daniel Bikle2. 1 University of California San Francisco/VA Medical Center, USA, 2Universiy of California San Francisco/VA Medical Center, USA Disclosures: Takuo Kubota, None

SU0072

Pleiotropy Involving Skeletal, Vascular, and Reproductive Phenotype in Recombinant Congenic Mice via the Endothelin Signaling Robert Blank1, michael johnson2, Jasmin Kristianto* 3, Suzanne Litscher2, Naomi Chesler2, Zhijie Wang2, Jacqueline Fisher2. 1University of Wisconsin, USA, 2University of Wisconsin-Madison, USA, 3University of Wisconsin–Madison, USA Disclosures: Jasmin Kristianto, None

SU0073

Prolonged Unloading in Growing Rats Reduces Cortical Osteocyte Lacunar Density and Volume in the Distal Tibia Hayley Britz*1, Yasmin Carter1, Jarkko Jokihaara 2, Olli Leppanen3, Teppo Jarvinen4, George Belev 5, David Cooper1. 1University of Saskatchewan, Canada, 2University of Tampere, Canada, 3University of Tampere, Finland, 4University of Tampere/IMT, Finland, 5 Canadian Light Source, Canada Disclosures: Hayley Britz, None

SU0074

Resistance to ER Stress Is Improved via Mechanical Input in MSC Maya Styner*1, Kornelia Galior1, Natasha Case1, Buer Sen 2, Zhihui Xie 1, Janet Rubin1. 1 University of North Carolina, Chapel Hill, School of Medicine, USA, 2University of North Carolina At Chapel Hill, USA Disclosures: Maya Styner, None

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING EFFECTS IN HUMANS AND INTACT ANIMALS SU0075

A 14-week Initial Military Training Regimen Led to Distal Trabecularization and Diaphyseal Cortical Thickening in Tibiae of Men and Women Charles Negus*1, Rachel Izard2, Julie Greeves3, William Fraser4. 1L-3 Applied Technologies, USA, 2HQ ARTD, MOD, United Kingdom, 3HQ Army Recruiting & Training Division, United Kingdom, 4Norwich Medical School, University of East Anglia, UK, United Kingdom Disclosures: Charles Negus, L-3 Jaycor, 3

146

SU0076

Bone and Muscle Loss Following Partial Weightbearing is Linearly Related to Loading Level Rachel Ellman*1, Alison Cloutier1, Jordan Spatz2, Mary Bouxsein1. 1Beth Israel Deaconess Medical Center, USA, 2Harvard-MIT Division of Health Sciences & Technology (HST), USA Disclosures: Rachel Ellman, None

SU0077

Longitudinal HR-pQCT Assessment of the Influence of Reduced Weight-Bearing on Bone Structure and Mechanics Willy Tjong1, Miki Sode2, Julio Carballido-Gamio 3, Andrew Burghardt1, Sharmila Majumdar1, Brian Feeley1, Benjamin Ma1, Galateia Kazakia*1. 1University of California, San Francisco, USA, 2University of California San Francisco & Berkeley, USA, 3Grupo Tecnolo´gico Santa Fe, S.A. de C.V., Mexico Disclosures: Galateia Kazakia, None

SU0078

Non-invasive (pQCT) Analysis of Different Patterns of Structural/Biomechanical Relationships Along the Human Tibia in Healthy Volunteers and Long-Distance Runners. Ricardo Francisco Capozza1, Sara Feldman2, Pablo Mortarino1, Paola Reina1, Jose Ferretti*3, Joern Rittweger4, Gustavo Roberto Cointry1. 1Center of P-Ca Metabolism Studies (CEMFoC), Natl Univ of Rosario, Argentina, Argentina, 2Laboratory for Bone Biology & Emerging Therapies (LABOATEM), Natl Univ of Rosario, Argentina, 3 National University of Rosario, Argentina, 4Div Space Physiology, Institute of Aerospace Medicine, German Space Agency (DLR), Germany Disclosures: Jose Ferretti, None

SU0079

Rapid Subchondral Bone Changes Immediately Following Non-Invasive Knee Injury In Mice Blaine Christiansen*, Matthew J. Anderson, Joel C. Williams, Cassandra A. Lee, Dominik R. Haudenschild. University of California - Davis Medical Center, USA Disclosures: Blaine Christiansen, None

SU0080

Site-Specific Skeletal Advantages at the Proximal Femur and Forearm in Young Female Gymnasts Jodi Dowthwaite* 1, Paula F. Rosenbaum2, Tamara Scerpella 3. 1State University of New York, Upstate Medical University, USA, 2SUNY Upstate Medical University, USA, 3 University of Wisconsin, USA Disclosures: Jodi Dowthwaite, None

SU0081

Sunday

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS TECHNIQUES A Novel Imaging Technique and Mouse Model for Evaluation of Osteoarthritis Zhechao Ruan*1, Brian Dawson2, Ming-Ming Jiang 2, Frank Gannon2, Michael Heggeness2, Brendan Lee 3. 1Baylor College of Medicine, USA, 2BCM, USA, 3Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Zhechao Ruan, None SU0082

Muscle and Bone Loss after Botox Injection in the Rat (MicroCT study) Beatrice Bouvard*1, Erick Legrand2, Maurice Audran3, Daniel Chappard4. 1university hospital of Angers, France, 2Centre Hospitalier d’Angers, France, 3Universite´ et CHU Angers; INSERM U922, France, 4INSERM, U922- LHEA, France Disclosures: Beatrice Bouvard, None

SU0083

Osteoarthritis (OA)-Induced Pain Assessment Rana Samadfam* 1, NANCY DOYLE2, Luc Chouinard 3, Susan Y. Smith1. 1Charles River Laboratories, Canada, 2CHARLES RIVER, Canada, 3Charles River Laboratories, PCS Montreal, Canada Disclosures: Rana Samadfam, None

SU0084

Osteonectin Expression in Synovial Fluid of Artificial Hip Joints with Different Articular Couplings Monica Montesi*1, Alina Beraudi1, Susanna Stea1, Francesco Traina2, Stefano Squarzoni3, Stefano Falcioni1, Aldo Toni2. 1Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Italy, 2Divisione di Ortopedia Traumatologia e Chirurgia Protesica e dei Reimpianti dell’anca e del ginocchio, Istituto Ortopedico Rizzoli, Italy, 3Istituto di Genetica Molecolare- CNR-, Italy Disclosures: Monica Montesi, None

147

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS: CALCIFICATION SU0085

Mechanisms of Longitudinal Overgrowth Following Circumferential Periosteal Division of Rat Femur Shinjiro Takata*1, Tetsuya Enishi2, Nori Sato2, Mitsuhiko Takahashi 2, Natsuo Yasui2. 1 Institute of Health Biosciences, University of Tokushima Graduate School, Japan, 2 Tokushima University Hospital, Japan Disclosures: Shinjiro Takata, None

SU0086

Nitric Oxide Synthase (NOS) in Mouse Femur during Endochondral Ossification Hiroki Watanabe 1, Toshihiro Nakagawa1, Yuriko Moro1, Shinya Takahashi2, Kimiharu Ambe*3. 1Ohu University School of Dentistry, Japan, 2Ohu university, graduate school of dentistry, Japan, 3OHU University, school of dentistry, Japan Disclosures: Kimiharu Ambe, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: CARTILAGE AND CHONDROCYTES SU0087

A Novel Double Fluorescent Strategy to Prospectively Isolate Label Retaining Chondrocytes at the Top of the Growth Plate Noriaki Ono*1, Takao Hirai2, Henry Kronenberg3. 1Massachusetts General Hospital & Harvard Medical School, USA, 2Kyoto Prefectural University of Medicine, Japan, 3 Massachusetts General Hospital, USA Disclosures: Noriaki Ono, None

SU0088

Acceleration of Chondrocyte Differentiation with a Peptide Exhibiting Osteoclastogenesis Inhibitory Activity and Osteogenesis Stimulatory Activity YURIKO FURUYA*, KOHJI UCHIDA, HISATAKA YASUDA. ORIENTAL YEAST CO.,LTD, Japan Disclosures: YURIKO FURUYA, ORIENTAL YEAST CO.,LTD., 3

SU0089

Activation of Wnt Planar Cell Polarity (PCP) Signaling Promotes Columnar Architecture of Growth Plate Chondrocytes In Vitro Rachel Randall*1, Yvonne Shao2, Lai Wang1, Robert Ballock3. 1Cleveland Clinic, USA, 2 CCF, USA, 3The Cleveland Clinic Foundation, USA Disclosures: Rachel Randall, None

SU0090

Essential Role of Cdc42 in Chondrogenesis and Interdigital Programmed Cell Death During Limb Development Ryo Aizawa*1, Atsushi Yamada2, Dai Suzuki3, Hidetoshi Kassai4, Takeshi Harada4, Masayuki Tsukasaki1, Gou Yamamoto1, Tadahiro Iimura5, Akira Yamaguchi 6, Kazuki Nakao4, Matsuo Yamamoto1, Atsu Aiba4, Ryutaro Kamijo1. 1Showa University School of Dentistry, Japan, 2Showa University School of Dentistry, Jpn, 3Showa University, Japan, 4 The University of Tokyo, Japan, 5Tokyo Medical & Dental University, Global Center of Excellence Program, Japan, 6Tokyo Medical & Dental University, Japan Disclosures: Ryo Aizawa, None

SU0091

Expression of Sclerostin in the Developing Zebrafish Brain and Skeleton Melissa McNulty 1, THEODORE CRAIG1, Victoria Bedell1, Tammy Greenwood 1, Stephen Ekker1, Rajiv Kumar*2. 1Mayo Clinic, USA, 2Mayo Clinic College of Medicine, USA Disclosures: Rajiv Kumar, None

SU0092

MEPE-ASARM Peptides: Novel Regulators of Growth Plate Mineralisation Colin Farquharson1, Vicky MacRae2, Katherine Staines*2. 1Roslin Institute, University of Edinburgh, United Kingdom, 2The Roslin Institute & R(D)SVS, The University of Edinburgh, United Kingdom Disclosures: Katherine Staines, None

SU0093

Notch Signaling during Chondrogenesis Shan Chen*1, Jianning Tao1, Ming-Ming Jiang1, Terry Bertin1, Brendan Lee2. 1Baylor College of Medicine, USA, 2Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Shan Chen, None

148

SU0094

PDGF-BB and CCL21 Mediate TGFb-Induced Migration during Development of Dorsal Vertebrae Ying Wang*, Rosa Serra. University of Alabama at Birmingham, USA Disclosures: Ying Wang, None

SU0095

The Alk2 R206H (FOP) Mutation Causes Lower Limb Chondrodysplasia in Mice Salin Chakkalakal*1, Andria Culbert 1, Michael Convente1, Deyu Zhang1, Frederick Kaplan2, Eileen Shore1. 1University of Pennsylvania, USA, 2University of Pennsylvania Hospital, USA Disclosures: Salin Chakkalakal, None

SU0096

The Role of Neogenin in Osteoarthritis Pathogenesis Zheng Zhou*, Lin Mei, Wencheng Xiong. Georgia Health Sciences University, USA Disclosures: Zheng Zhou, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENE IDENTIFICATION AND EXPRESSION SU0097

Identification of Human Bone Cell Characteristic Transcripts and their Interactions Using Online Browser Based Search In a Giant Correlation Matrix Sjur Reppe*1, Daniel Sachse1, Ole K. Olstad1, Vigdis T. Gautvik2, Paul Sanderson3, Harish Datta4, Jens P. Berg1, Kaare Gautvik1. 1Oslo University Hospital, Norway, 2University of Oslo, Norway, 3Newcastle General Hospital, United Kingdom, 4Newcastle University, United Kingdom Disclosures: Sjur Reppe, None

SU0098

In Vivo Study of Msx1 Involvement in Alveolar Bone Growth Sylvie Babajko*1, Ibtisam Senussi2, Fleur Me´ary3, Sophia Loiodice4, Ariane Berdal5. 1 INSERM, France, 2Inserm U872 Universite´ Paris 6, France, 3Inserm U872, France, 4 Inserm U872 Universite´ Paris 7, France, 5Universite´ de Paris 7, France Disclosures: Sylvie Babajko, None

SU0099

Disclosures: Roman Thaler, None SU0100

Pannexin 3 Plays a Critical Role for Odontoblast Differentiation Tsutomu Iwamoto*, YU SUGAWARA, Mariko Ono, Aya Yamada, Takashi Nakamura, Satoshi Fukumoto. Tohoku University Graduate School of Dentistry, Japan Disclosures: Tsutomu Iwamoto, None

SU0101

RNA Editing Occurs in the Bone and is Modulated by Dietary Fat Intake Tongjun Gu, Cheryl Ackert-Bicknell, F. William Buaas, Allen Simons, Robert Braun, Matthew Hibbs*. The Jackson Laboratory, USA Disclosures: Matthew Hibbs, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENERAL SU0102

Hox11 Genes in Musculoskeletal Patterning, Integration and Fracture Repair Ilea Swinehart*1, Kenneth Kozloff2, Steven Goldstein3, Deneen Wellik4. 1University of Michigan, USA, 2University of Michigan Department of Orthopaedic Surgery, USA, 3 University of Michigan Orthopedic Research Labs, USA, 4University of Michigan Medical Center, USA Disclosures: Ilea Swinehart, None

SU0103

A Homozygous Lethal Mutation in Connexin 43 Leads to Abnormal Skeletal Development in Zebrafish Jiuann-Huey Lin1, Yvonne Matos1, Matthew Goldsmith*2. 1Washington University in St. Louis, USA, 2Washington University School of Medicine, USA Disclosures: Matthew Goldsmith, None

149

Sunday

Is Serum Amyloid A3 (Saa3) a Link Between Hyperhomocysteinemia and the Development of Degenerative Skeletal Pathologies? Roman Thaler*1, Monika Rumpler2, Silvia Spizter2, Eleftherios Paschalis3, Sonja Gamsjaeger 2, Klaus Klaushofer 4, Franz Varga2. 1Ludwig Boltzmann Institute of Osteology, Austria, 2Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling. 1st Medical Department, Hanusch Hospital, Austria, 3Ludwig Boltzmann Institute for Osteology, Austria, 4Hanusch Hospital, Austria

SU0104

Allogenic Demineralized Dentin Matrix, an Ideal Bone Graft Biomaterial Neema Bakhshalian*1, Shirin Hooshmand1, Sara Campbell2, Bahram Arjmandi1. 1Florida State University, USA, 2Rutgers Univeristy, USA Disclosures: Neema Bakhshalian, None

SU0105

Characterization of A Non-Invasive Model of Periodontitis and Alveolar Bone Loss in Rice Rats (Oryzomys palustris) J. Aguirre*1, Mohammed Akhter2, Donald Kimmel3, Jennfer Pingel4, Xuechun Xia4, Aly Williams4, Marda Jorgensen5, Kent Edmonds6, Ju-Youn Lee 7, Lakshmyya Kesavalu7, Thomas Wronski1. 1University of Florida, USA, 2Osteoporosis Research Center, Creighton University, USA, 3Kimmel Consulting Services, USA, 4Department of Physiological Sciences, University of Florida, USA, 5Cell & Tissue Analysis Core, McKnight Brain Institute, University of Florida, USA, 6Department of Biology, Indiana University Southeast, USA, 7Department of Periodontology & Oral Biology, College of Dentistry, University of Florida, USA Disclosures: J. Aguirre, None

SU0106

Fourteen-month Changes in Volumetric BMD of Radius and Tibia upon Antidepressant Drug Administration in Young Depressive Patients Laima Winterhalder1, Jolanda Widmer 2, Prisca Eser2, Peter M Villiger2, Daniel Aeberli*3. 1 Private psychiatric clinic Wyss, Switzerland, 2Dept. of Rheumatology/Clinical Immunololgy University Hospital Berne, Switzerland, 3Dept. of Rheumatology & Clinical Immunology/Allergology University Hospital, Switzerland Disclosures: Daniel Aeberli, None

SU0107

Identification of Adipocyte Mediated Osteogenesis Adam Taylor*1, Alan Boyde2, Jonathan Jarvis3, Lakshminarayan Ranganath3, James Gallagher4. 1University of Liverpool, GBR, 2Institute of Dentistry, Barts & The London School of Medicine & Dentistry, United Kingdom, 3Musculoskeletal Biology, University of Liverpool, United Kingdom, 4University of Liverpool, United Kingdom Disclosures: Adam Taylor, None

SU0108

Molecular Mechanism of CIZ Actions to Exacerbate Inflammation in Serum-induced Arthritis Based on Formation of Positive Feedback Loop with IL-1 Beta Tetsuya Nakamoto*1, Takayuki Motoyoshi2, Makiri Kawasaki2, Tomomi Sakuma1, Tadayoshi Hayata3, Yoichi Ezura4, Masaki Noda1. 1Tokyo Medical & Dental University, Japan, 2Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical & Dental University, Japan, 3Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 4Tokyo Medical & Dental University, Medical Research Insititute, Japan Disclosures: Tetsuya Nakamoto, None

SU0109

Standardization of proteoliposome systems containing Alkaline Phosphatase and Annexin V: kinetic characterization at physiological pH Mayte Bolean*1, Ana Maria Simao2, Tina Moreira3, Marc Hoylaerts4, Jose Luis Millan3, Pietro Ciancaglini 1. 1FFCLRP-USP, Brazil, 2University of Sao Paulo - USP, Brazil, 3 Sanford-Burnham Medical Research Institute, USA, 4Center for Molecular & Vascular Biology, University of Leuven, Belgium Disclosures: Mayte Bolean, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: MATRIX PROTEINS SU0110

Determining the Function of WISP-1/CCN4 in Mineralized Tissue Azusa Maeda*1, Mitsuaki Ono1, Tina Kilts 1, Kenn Holmbeck 2, Karen Lyons3, Marian Young1. 1National Institutes of Health, USA, 2NIDCR, USA, 3University of California, Los Angeles, USA Disclosures: Azusa Maeda, None

SU0111

Withdrawn

SU0112

Fluid Osteocalcin Levels Correlate to Bone and Cartilage Matrix Measures in a Small Study of Men with Severe Osteoarthritis and Co-morbid Diabetes Mellitus Karen King*1, Trevor Oren 2, Allan Bucknell2. 1University of Colorado School of Medicine, USA, 2Eastern Colorado Health Care System, USA Disclosures: Karen King, DePuy Orthopaedics Inc., 2; Cerapedics, 5

150

SU0113

Periostin: A Novel Serum Marker of Cortical Bone Formation Nicolas Bonnet*1, Jean charles Rousseau2, Patrick Garnero3, Serge Ferrari 4. 1Division of Bone Diseases, Geneva University Hospital & Faculty of Medicine, S, Switzerland, 2 INSERM UMR 1033, Universite´ de Lyon, France, 3INSERM UMR 1033, Universite´ de Lyon & Cisbio Bioassays, France, 4Geneva University Hospital & Faculty of Medicine, Switzerland Disclosures: Nicolas Bonnet, None

SU0114

Quantitative Analysis of Fibronectin Fibril Assembly Dynamics in Living Osteoblast Cultures Aditya Roshan*, Ganesh Thiagarajan, Sarah Dallas. University of Missouri - Kansas City, USA Disclosures: Aditya Roshan, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: MECHANICAL STRESS SU0115

Moderate Joint Loading Downregulates MMPs 1, 3, and 13 in Mouse Articular Cartilage Hiroki Yokota*1, Daniel J. Leong2, Robert Majeska3, Herb Sun2. 1Indiana University Purdue University Indianapolis, USA, 2Mount Sinai School of Medicine, USA, 3City College of New York, USA Disclosures: Hiroki Yokota, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: PROTEINASES SU0116

Matrix Metalloproteinase-13-mediated Cortical Bone Remodeling Is Required for the Postnatal Maintenance of Bone Quality Simon Tang*, Tamara Alliston. University of California, San Francisco, USA Disclosures: Simon Tang, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: CALCITONIN AND RELATED PEPTIDES SU0117

Disclosures: David Komatsu, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: FGF23 AND OTHER PHOSPHATONINS SU0118

Deletion of Cyp24a1 in Klotho-Null Mice Leads to Early Death Xiuying Bai*1, Dinghong Qiu1, Rene St-Arnaud2, David Goltzman3, Andrew Karaplis4. 1 Lady Davis Institute, Canada, 2Shriners Hospital for Children & McGill University, Canada, 3McGill University Health Centre, Canada, 4McGill University, Can Disclosures: Xiuying Bai, None

SU0119

Effect of Phosphate Overload on Podocyte of Glomerulus in the Kidney Sahoko Sekiguchi-Ueda*1, Shogo Asano2, Megumi Shibata3, Yasumasa Yoshino4, Hiroyuki Hirai4, Yoshiteru Maeda4, Masaki Makino4, Nobuki Hayakawa 4, Atsushi Suzuki5, Mitsuyasu Itoh4. 1Fujita Health University, Division of Endocrinology, Jpn, 2 Toyokawa City Hospital, Japan, 3Fujita Health University, Division of Endocrinology, Japan, 4Fujita Health University, Japan, 5Fujita Health University Division of Endocrinology, Japan Disclosures: Sahoko Sekiguchi-Ueda, None

SU0120

PHEX and Fat Energy Metabolism across a Bone-Renal Axis Peter Rowe*1, Anne-Marie Hedge2, Yan Hong2, Valentin David3, Lesya Zelenchuk 2. 1 University of Kansas Medical Center, USA, 2KUMC, USA, 3UTHSC, USA Disclosures: Peter Rowe, None

151

Sunday

Calcitonin Receptor Peptide: A Novel Peptide That Enhances Osteoblast Differentiation and Matrix Mineralization David Komatsu*1, Srinivas Pentyala2, Julie Miller 2, Supriya Mishra2, Kyle Urbanczyk2, Sirish Kondabolu2, Joshua J. Hinkle3, Michael Hadjiargyrou4. 1Stony Brook University, Dept. of Orthopaedics, USA, 2Stony Brook University, Dept. of Anesthesiology, USA, 3 Stony Brook University, Dept. of Biomedical Engineering, USA, 4State University of New York at Stony Brook, USA

SU0121

Phosphate and Vitamin D Homeostasis after Live Donor Nephrectomy: Activation of the FGF-23 pathway. Ann Young1, Anthony Hodsman*1, David Goltzman2, Amit Garg1, for the Donor Nephrectomy Outcomes Research (DONOR) Network1. 1University of Western Ontario, Canada, 2McGill University Health Centre, Canada Disclosures: Anthony Hodsman, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: PARATHYROID AND PARATHYROID HORMONE-RELATED PEPTIDE SU0122

Administration of PTH1-34 Partially Rescues Hematopoietic Defects in Bmi1 Null Mice by Improving the Hematopoietic Microenvironment Ruinan Lu*1, Qian Wang1, David Goltzman2, Dengshun Miao3. 1Nanjing Medical University, China, 2McGill University Health Centre, Canada, 3Nunjing Medical University, Peoples Republic of China Disclosures: Ruinan Lu, None

SU0123

Anabolic Skeletal Effects after Discontinuation of Human Synthetic Parathyroid Hormone 134 (PTH) Replacement Therapy in Hypoparathyroidism (HPT) Rachel Gafni*1, C. Michele Christie 2, Marilyn H. Kelly3, Beth A. Brillante3, James Reynolds 1, Hua Zhou4, David W. Dempster5, Michael Collins1. 1National Institutes of Health, USA, 2Department of Pediatrics, Kaiser Permanente, USA, 3SCSU, CSDB, NIDCR, National Institutes of Health, USA, 4Helen Hayes Hospital, USA, 5Regional Bone Center, Helen Hayes Hospital, USA Disclosures: Rachel Gafni, None

SU0124

Dynamic formation of a PTH/PTHrP receptor2arrestin2Gs signaling complex in bone cells Vanessa L. Wehbi*1, Timothy N. Feinstein2, Guillermo Romero2, Jean-Pierre Vilardaga3. 1 University of Pittsburgh, USA, 2University of Pittsburgh, School of Medecine, Department of Pharmacology & Chemical Biology, USA, 3University of Pittsburgh, School of Medicine, USA Disclosures: Vanessa L. Wehbi, None

SU0125

Elderly Men in Hong Kong Have Higher Serum Vitamin D and Lower Serum Parathormon Compared to Gothenburg. Mr Os Ewa Waern*1, Claes Ohlsson2, R Chan3, Timothy Kwok3, PC Leung4, Egil Haug 5, Magnus Karlsson6, Osten Ljunggren 7, Dan Mellstrom1. 1Sahlgrenska University Hospital, Sweden, 2 Centre for Bone & Arthritis Research, Sweden, 3The Chinese University of Hong Kong, Hong Kong, 4The Chinese Univeristy of Hong Kong, Hong Kong, 5Hormone Laboratory, Aker University Hospital, Norway, 6Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 7Uppsala University Hospital, Sweden Disclosures: Ewa Waern, None

SU0126

Nuclear Actions of PTHrP Contribute to the Differentiation of the Mammary Mesenchyme. Kata Boras-Granic*1, Pamela Dann1, Andrew Karaplis2, John Wysolmerski 1. 1Yale University School of Medicine, USA, 2McGill University, Canada Disclosures: Kata Boras-Granic, None

SU0127

p85a Subunit of PI3K Mediates Bone Loss Induced by Continuous PTH Infusion Rajendra Kedlaya*1, Reuben Kapur1, Alexander Robling2. 1Indiana University School of Medicine, USA, 2Indiana University, USA Disclosures: Rajendra Kedlaya, None

SU0128

Parathyroid Hormone Reduces Oxidative Stress in Bone by Preventing Activation of p66Shc and by Stimulating the Expression of Aldehyde Dehydrogenase 3a1. Robert Jilka*, Annick DeLoose, Kanan Vyas, Maria Almeida, Stavros Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Robert Jilka, Radius Health, Inc., 1

SU0129

Persistently Elevated Parathormone after 12 Months of Parathyroid Adenoma Surgery Rabindera Mehrotra*. Apollo Hospitals, India Disclosures: Rabindera Mehrotra, None

152

SU0130

PTH Skeletal and Bone Healing Efficacy in T-Cell Deficient and Normal Rats are Similar. Masahiko Sato* 1, M.D. Adrian1, Matt Hamang1, Q.Q. Zeng1, Yanfei Ma2. 1Lilly Research Labs, USA, 2Eli Lilly & Company, USA Disclosures: Masahiko Sato, Lilly Research Labs, 3

SU0131

The Effect of JTT-305 (MK-5442), an Orally Active Calcium-sensing Receptor Antagonist, on Calcium Metabolism in Parathyroidectomized Rats Mikio Hayashi*, Takashi Nakagawa, Mariko Maekawa, Shuichi Kimura. Central Pharmaceutical Research Institute, JAPAN TOBACCO INC., Japan Disclosures: Mikio Hayashi, JAPAN TOBACCO INC., 3

CANCER AND BONE: BREAST AND PROSTATE SU0132

TWEAK and FN14 Signaling Through NFkB is Necessary for the RAS Effector Mutant Human Prostate Cancer Cell Line DU145/RasV12G37 to Form Bone Metastasis Kristin J Lastwika*1, Victoria Seng2, Kirsten Tracy 2, Juan Juan Yin3, Kathleen Kelly2. 1 George Washington University Institute for Biomedical Sciences, USA, 2Cell & Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, USA, 3National Cancer Institute, USA Disclosures: Kristin J Lastwika, None

SU0133

A Non-invasive Way to Target microRNA-21 and to Prevent Osteometastatic CSF-1 Expression by the Human Breast Cancer Cells via PTEN Chandi Mandal*1, Triparna Ghosh-Choudhury2, Goutam Ghosh Choudhury1, Nandini Ghosh-Choudhury1. 1University of Texas Health Science Center at San Antonio, USA, 2 Baylor College of Medicine, USA Disclosures: Chandi Mandal, None

SU0134

Breast Cancer Stem Cells Metastatize to Bone in a Human in Mice Model Lucia D’Amico* 1, Salvatore Patane`2, Cristina Grange3, Benedetta Bussolati3, Patrizia D’Amelio4, Giancarlo Isaia4, Riccardo Ferracini 5, Ilaria Roato6. 1Azienda OspedalieroUniversitaria Molinette San Giovanni Battista, Italy, 2CeRMS, Italy, 3Department of Internal Medicine, Molecolar Biotechnology Center, University of Turin, Italy, 4University of Torino, Italy, 5Department of Orthopaedics, A.O.U. San Giovanni Battista, Italy, 6 A.O.U. San Giovanni Battista, Italy Disclosures: Lucia D’Amico, None

Characterization of the Bone Metastatic Potential of Different Tumor Cell Lines Sophie Baret*, Ingrid Stockmans, Riet Van Looveren, Geert Carmeliet. Katholieke Universiteit Leuven, Belgium Disclosures: Sophie Baret, None

SU0136

Current Practices of Screening, Prevention and Treatment of Androgen Deprivation Therapy (ADT) induced Osteoporosis in patients with Prostate Cancer Arthur Lau*1, Humaid Al-Shamsi 2, Kartika Malik3, George Ioannidis1, Jonathan Adachi4, Alexandra Papaioannou 5. 1McMaster University, Canada, 2McMaster University, Department of Medical Oncology, Canada, 3University of Toronto, Department of Geriatrics, Canada, 4St. Joseph’s Hospital, Canada, 5Hamilton Health Sciences, Canada Disclosures: Arthur Lau, None

SU0137

Dual Actions of Klotho in Breast Cancer Cells Cause Resistance to TGFbeta and Vitamin D Pierrick Fournier*, Daniel Edwards, John Chirgwin. Indiana University, USA Disclosures: Pierrick Fournier, None

SU0138

Induction of perlecan/HSPG2 Expression in Desmoplastic Bone Marrow Stromal Cells Curtis Warren*, Daniel Carson, Mary Farach-Carson. Rice University, USA Disclosures: Curtis Warren, None

SU0139

Number Needed to Treat and Risk Benefit Analysis of Denosumab Versus Zoledronic Acid in the Treatment of Castrate-Resistant Prostate Cancer Patients with Bone Metastases Andrew P Yu1, Melissa Diener1, Eric Q Wu1, Madhav Namjoshi* 2. 1Analysis Group, Inc., USA, 2Novartis Oncology, USA Disclosures: Madhav Namjoshi, None

153

Sunday

SU0135

SU0140

Osteoporosis-specific Quality of Life Change in the B-ABLE Cohort of Women on Aromatase Inhibitor Therapy: Predictors at 1-year Follow-up. Daniel Prieto-alhambra*1, Sonia Servitja2, Laia Garrigos2, Elisa Torres2, Maria MartinezGarcia2, Josep Blanch3, Joan Albanell2, Adolfo Diez-Perez4, Ignasi Tusquets 2, Xavier Nogues5. 1Institut Municipal D’Investigacio´ Me`dica, Spain, 2Medical Oncology Department, Breast Cancer Unit. Molecular Therapeutics & Biomarkers in Breast Cancer, Cancer Research Program, IMIM-Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain, Spain, 3Rheumatology Department, Parc de Salut Mar, Barcelona (Spain), Spain, 4Department of Internal Medicine, URFOA IMIM-Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona, RETICEF (Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain, Spain, 5RETICEF (Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain, Spain Disclosures: Daniel Prieto-alhambra, None

SU0141

PTHrP Promotes Epithelial-To-Mesenchymal Transition and the Acquisition of Cancer Stem Cell-Like Properties in Prostate Cancer Douglas Burton*1, Weg Ongkeko2, Alan Kiang 3, Eric Abhold3, David Yi3, Leonard Deftos4. 1VA San Diego Healthcare System / University of California, San Diego, USA, 2 University of California San Diego / VMRF, USA, 3University of California San Diego, USA, 4Veterans Administration San Diego Healthcare System & University of California, USA Disclosures: Douglas Burton, None

SU0142

The Vitamin D Receptor Promotes Human Prostate Cancer Cell Growth via a Ligand Independent Pathway Yu Zheng*1, Difei Deng2, Dennis Basel2, Trupti Trivedi1, Julian Kelly2, Robert L Sutherland 3, Colin Dunstan 4, Dr. Hong Zhou5, Markus Seibel5. 1Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 2ANZAC Research Institute, the University of Sydney, Australia, 3Cancer Research Program, Garvan Institute of Medical Research, Australia, 4University of Sydney, Australia, 5Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Yu Zheng, None

SU0143

TRPV6 Ion Channels Modulate Human Metastatic Prostate Cancer Cell Migration and Adhesion Sarah Mccarthy*, Ronald R. Gomes. Penn State Hershey, USA Disclosures: Sarah Mccarthy, None

CANCER AND BONE: GENERAL SU0144

SQSTM1 Mutations Are not Common in Pagetic Osteosarcomas nor in High Grade Osteosarcomas Pui Yan Jenny Chung1, Piero Picci 2, Marco Alberghini3, lars-gunnar Kindblom4, Patrick D’Haese1, John-Paul Bogers1, Leida Rozeman5, Pancras Hogendoorn 5, Wim Van Hul*1. 1 University of Antwerp, Belgium, 2 Istitute ortopedica Rizzoli, Italy, 3Istituto Ortopedica Rizzoli, Italy, 4Royal Orthopedic Hospital, United Kingdom, 5Leiden University Medical Center, Netherlands Disclosures: Wim Van Hul, None

SU0145

Altered Bone Marrow Adiposity Following Localized Irradiation in Juvenile Mice Lihini Keenawinna*1, Megan Oest 1, Timothy Damron2. 1SUNY Upstate Medical University, USA, 2State University of New York Upstate Medical University, USA Disclosures: Lihini Keenawinna, None

SU0146

Cisplatin Treatment Inhibits Bone Healing: Implications for Osteosarcoma Surgery Larry Suva*1, Kimo Stine1, Elizabeth Wahl1, Lichu Liu1, James Aronson1, Robert Skinner 1, Kathryn Thrailkill2, Corey Montgomery 1, John Fowlkes1, David Becton1, Charles Lumpkin1. 1University of Arkansas for Medical Sciences, USA, 2Arkansas Children’s Hospital, USA Disclosures: Larry Suva, None

154

SU0147

Development and Validation of a Pre-clinical Model of Radiation Impaired Fracture Healing Katarina Janic*1, Fred Nicholls2, Tom Willett3, Marc Grynpas3, Peter Ferguson 4. 1Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Canada, 2University of Toronto, Department of Surgery, Division of Orthopedic Surgery, Canada, 3Samuel Lunenfeld Research Institute, Canada, 4Division of Orthopedic Surgery, Mount Sinai Hospital, Canada Disclosures: Katarina Janic, None

SU0148

Epigenetic Signatures of Osteosarcoma Emma Baker*1, Dario Strbenac2, Thomas John Martin3, Louise Purton1, Mark Robinson 4, Carl Walkley1. 1St. Vincent’s Institute, Australia, 2Garvan Institute of Medical Research, Australia, 3St. Vincent’s Institute of Medical Research, Australia, 4WEHI, Australia Disclosures: Emma Baker, None

SU0149

Withdrawn

SU0150

Locally Administered Zoledronic Acid Therapy for Giant Cell Tumor of Bone Toshihiko Nishisho* 1, Naoyoshi Hanaoka2, Kenji Endo2, Mitsuhiko Takahashi 2, Natsuo Yasui3. 1The University of Tokushima, Institute of Health Bioscience, School of Medicine, Japan, 2Department of Orthopedics, The University of Tokushima, Japan, 3University, Japan Disclosures: Toshihiko Nishisho, None

SU0151

Mechanical Signals Partially Preserve Bone Quality in Animal Models of Ovarian Cancer While Promoting the Mesenchymal Progenitor Pool’s Efficacy in Slowing Complications of the Disease Gabriel Pagnotti*1, Benjamin Adler1, Danielle Green1, Ete Meilin Chan1, Wesley Beamer2, Kenneth Shroyer3, Clinton Rubin4. 1Stony Brook University, USA, 2The Jackson Laboratory, USA, 3Stony Brook University Medical Center, USA, 4State University of New York at Stony Brook, USA Disclosures: Gabriel Pagnotti, None

SU0152

Disclosures: Vaibhav Saini, None SU0153

Potential Risk Factors for Bisphosphonate-related Osteonecrosis of the Jaw: Retrospective Analysis of 576 Cancer Patients Vivek Thumbigere-Math1, Lam Tu1, Sabrina Huckabay1, Scott Lunos2, Arkadiusz Dudek3, Karen Swenson4, Joseph Leach4, Pamela Hughes1, David Basi1, Raj Gopalakrishnan*5. 1University of Minnesota School of Dentistry, USA, 2University of Minnesota CTSI Academic Health Center, USA, 3University of Minnesota Cancer Center, USA, 4Park Nicollet Institute, USA, 5University of Minnesota, USA Disclosures: Raj Gopalakrishnan, None

SU0154

Radiation Induced Bone Loss: A Dose Response PET-CT Study Orhan Oz*1, Jon Anderson 2, Rohama Khajia3, Keenan Brown4, Paul Medin2. 1University of Texas Southwestern Medical Center, Dallas, USA, 2UT Southwestern Medical Center at Dallas, USA, 3Mindway Software, USA, 4Mindways Software, USA Disclosures: Orhan Oz, None

SU0155

Raman Spectroscopy Demonstrates Amifostine-Induced Protection of Bone Quality in the Irradiated Murine Mandible Catherine Tchanque-Fossuo*1, Bo Gong2, Behdod Poushanchi 2, K. Kelly Gallagher2, Deniz Sarhaddi2, Alexis Donneys2, Sagar S. Deshpande2, Michael Morris2, Steven Goldstein 3, Steven R. Buchman2. 1Plastic Surgery Research Fellow, USA, 2University of Michigan, USA, 3University of Michigan Orthopedic Research Labs, USA Disclosures: Catherine Tchanque-Fossuo, None

155

Sunday

Novel Biomarkers and Therapeutic Agents for Osteosarcoma Stem Cells Vaibhav Saini* 1, Curtis Hose2, Anne Monks2, Mark Burkett2, Bingnan Han2, Dianne Newton3, Angelena Millione2, Jalpa Shah2, Melinda Holingshead3, Kunio Nagashima2, Rene Delosh2, Karen Hite 2, Thomas Silver2, Dominic Scudiero2, Paola Pajevic Divieti4, Robert Shoemaker3. 1Research Fellow, MGH, Harvard Medical School, USA, 2SAIC, USA, 3NCI, USA, 4MGH- Harvard Medical School, USA

SU0156

Role of CIZ in Melanoma Activity for Metastasis Hiroaki Hemmi1, Takuya Notomi2, Tetsuya Nakamoto3, Tadayoshi Hayata4, Yoichi Ezura5, Tomomi Sakuma* 3, Masaki Noda3. 1Immunology Frontier Research Center, Osaka University, Japan, 2GCOE, Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5Tokyo Medical & Dental University, Medical Research Insititute, Japan Disclosures: Tomomi Sakuma, None

DISORDERS OF MINERAL METABOLISM: CONGENITAL AND GENETIC BONE DISEASES SU0157

Development of a High-throughput Screening (HTS) Assay for the Identification of Small Molecule Modulators of Gsa Nisan Bhattacharyya*1, Dr. Catherine Chen2, Dr. Wei Zheng2, Dr. John K. Northup3, Dr. Susanne Neumann4, Dr. Michael T. Collins5. 1NIDCR, NIH, USA, 2National Chemical Genomics Center, NHGRI, NIH, USA, 3Laboratory of Cell Biology, NIDCD, NIH, USA, 4 Clinical Endocrinology Branch, NIDDK, NIH, USA, 5Skeletal Clinical Studies Unit, CSDB, NIDCR, NIH, USA Disclosures: Nisan Bhattacharyya, None

SU0158

Elevated sclerostin in individuals with High Bone Mass Celia Gregson* 1, Kenneth Poole2, Susan Steel3, John Ayuk4, Emma Duncan5, Eugene McCloskey 6, William Fraser 7, J.H. Tobias8. 1University of Bristol, United Kingdom, 2 University of Cambridge, United Kingdom, 3Hull & E Yorks Hospital Trust, United Kingdom, 4University Hospitals Birmingham NHS Foundation Trust, United Kingdom, 5 Royal Brisbane & Women’s Hospital, Australia, 6University of Sheffield, United Kingdom, 7Norwich Medical School, University of East Anglia, United Kingdom, 8Avon Orthopaedic Centre, United Kingdom Disclosures: Celia Gregson, None

SU0159

Modest Reversal of Metabolic Syndrome Manifestations with Vitamin D Correction: A 12month Prospective Study Nasser Al-Daghri*. King Saud University, Saudi Arabia Disclosures: Nasser Al-Daghri, None

SU0160

Severity of Knee Osteoarthritis Correlates with Estradiol and Leptin Levels in Serum and Synovial Fluid of Osteoarthritic Patients. Shirin Hooshmand*1, Jenna Schmidt2, Bahram Arjmandi1. 1Florida State University, USA, 2 Florida State Univeristy, USA Disclosures: Shirin Hooshmand, None

DISORDERS OF MINERAL METABOLISM: IDIOPATHIC HYPERCALCIURIA, NEPHROLITHIASIS SU0161

RANKL Over-Expression and Enhanced Bone Marrow Monocyte Response to RANKL Contribute to Low Bone Mass in Genetic Hypercalciuric Stone-Forming (GHS) Rats Hongwei Wang*1, Honggang Ye1, Jinhua Wang1, Soo Young Park1, David Bushinsky2, Murray Favus1. 1University of Chicago, USA, 2University of Rochester, USA Disclosures: Hongwei Wang, None

DISORDERS OF MINERAL METABOLISM: OSTEOMALACIA/RICKETS SU0162

Treatment of Tumor Induced Osteomalacia with CT-guided Percutaneous Ethanol Ablation and Percutaneous Cryoablation Erik Olson, Sean Tutton, David King, Joseph Shaker*. Medical College of Wisconsin, USA Disclosures: Joseph Shaker, None

SU0163

What Is the Minimal Serum 25-hydroxyvitamin D (25-OHD) Level for Optimal Skeletal Mineralization? Sudhaker Rao*, Shijing Qiu, Tarlisha Eskridge, Nayana Parikh, Saroj Palnitkar. Henry Ford Hospital, USA Disclosures: Sudhaker Rao, None

156

DISORDERS OF MINERAL METABOLISM: PAGET’S DISEASE SU0164

Double Blind, Double Dummy, Randomized Controlled Trial of Oral Bisphosphonates (OB) in the Treatment of Active Pagets Bone Disease (PBD) Juan Carlos Barreira1, Zulema Man2, Claudia Gomez Acotto3, Emilio Roldan*4. 1Hospital Brita´nico, Argentina, 2Centro Me´dico TIEMPO, Argentina, 3Maimo´nides Univ., Argentina, 4Gador S.A., USA Disclosures: Emilio Roldan, None

SU0165

Prediction of Paget’s Disease of Bone Using Genetic Profiling Omar Albagha*1, W.D. Fraser2, P.L. Selby3, Stuart Ralston1. 1University of Edinburgh, United Kingdom, 2Royal Liverpool University Hospita, United Kingdom, 3Manchester Royal Infirmary, United Kingdom Disclosures: Omar Albagha, None

DISORDERS OF MINERAL METABOLISM: PARATHYROID DISEASES SU0166

Aortic Valve Calcification is Increased in Mild Primary Hyperparathyroidism Marcella Walker*, Shinichi Iwata, Eiichi Hyodo, Zhezhen Jin, Rui Liu, Marco DiTullio, Shunichi Homma, Shonni J. Silverberg. Columbia University, USA Disclosures: Marcella Walker, None

SU0167

Asymptomatic Normocalcemic Primary Hyperparathyroidism: Characterization of a New Phenotype of Normocalcemic Primary Hyperparathyroidism Natalie Cusano*1, Patty Wang2, Serge Cremers3, Elizabeth Haney4, Douglas Bauer5, Eric Orwoll4, John Bilezikian1. 1Columbia University College of Physicians & Surgeons, USA, 2 Department of Medicine, Oregon Health & Science University, USA, 3Columbia University, USA, 4Oregon Health & Science University, USA, 5University of California, San Francisco, USA Disclosures: Natalie Cusano, None

SU0168

Basal Insulin Secretion is Correlated with Serum Undercarboxylated Osteocalcin (ucOC) Levels in Patients with Primary Hyperparathyroidism Hisanori Suzuki*1, Akira Takeshita1, Megumi Miyakawa1, Daishu Miura2, Yasuhiro Takeuchi3. 1Toranomon Hospital Endocrine Center, Japan, 2Department of Breast & Endocrine Surgery, Toranomon Hospital, Japan, 3Toranomon Hospital, Japan Disclosures: Hisanori Suzuki, None

CDKN1B/p27kip1 Gene: Sequence Analysis in a Group of Sporadic Parathyroid Adenomas Claudio Marcocci*1, Elena Pardi2, Simona Borsari2, Benedetta Raspini2, Elena Paltrinieri2, Federica Saponaro2, Chiara Banti2, Antonella Picone2, Piero Berti3, Paolo Miccoli3, Filomena Cetani1. 1University of Pisa, Italy, 2University of Pisa Department of Endocrinology & Metabolism, Italy, 3University of Pisa Department of Surgery, Italy Disclosures: Claudio Marcocci, None

SU0170

Depression in Primary Hyperparathyroidism: Prevalence and Sustained Benefit of Parathyroidectomy Rachel Espiritu, Ann Kearns, Kristin Vickers Douglass, Clive Grant, Euijung Ryu, Robert Wermers*. Mayo Clinic, USA Disclosures: Robert Wermers, None

SU0171

Establishment of Parathyroid hormone (PTH) Reference Range on 10 Different Assay Kits: Impact of the Recruitment of the Population Etienne Cavalier*1, Jean-Claude Souberbielle 2. 1University of Liege, CHU Sart-Tilman, Belgium, 2Hopital Necker-Enfants malades, France Disclosures: Etienne Cavalier, None

SU0172

Germline and Somatic DNA Variants in Cyclin-Dependent Kinase Inhibitor Genes in Sporadic Parathyroid Adenomas Jessica Costa-Guda*1, Chen-Pang Soong2, Andrew Arnold2. 1University of Connecticut Health Center, USA, 2University of Connecticut School of Medicine, USA Disclosures: Jessica Costa-Guda, None

157

Sunday

SU0169

SU0173

Relative Prevalence of Normocalcemic and Hypercalcemic Hyperparathryoidism in a Community-Dwelling Cohort Claudie Berger*1, Lisa Langsetmo 2, David Hanley3, Jonathan Adachi4, Christopher Kovacs5, Jacques Brown6, Robert Josse7, David Goltzman8. 1McGill University, Canada, 2 Canandian Multicenter Osteoporosis Study, Canada, 3University of Calgary, Canada, 4St. Joseph’s Hospital, Canada, 5Memorial University of Newfoundland, Canada, 6Laval University, Canada, 7St. Michael’s Hospital, University of Toronto, Canada, 8McGill University Health Centre, Canada Disclosures: Claudie Berger, None

SU0174

Repair of Fracture Nonunion Using a Combination of Low Dose rhFGF-2 and rhIGF-I; Case Report Ashraf Moharam1, Hsiu Ying Sherry Wang2, Marina D’Angelo3, Abdulhafez Selim*4. 1 Orthopedic Surgery, Cairo University School of Medicine, Egypt, 2Inspire Pharm, Egypt, 3 Philadelphia College of Osteopathic Medicine, USA, 4Center for Chronic Disorders of Aging, PCOM, USA Disclosures: Abdulhafez Selim, None

DISORDERS OF MINERAL METABOLISM: RENAL BONE DISEASE SU0175

Daily Activity and Tests of Muscle Strength Are Associated With Fractures in Stage 3-5 Chronic Kidney Disease Sarah West*1, Charmaine E. Lok2, Maryum Chaudhry2, Scott G. Thomas1, Sophie Jamal3. 1 University of Toronto, Canada, 2Toronto General Hospital, Canada, 3The University of Toronto, Canada Disclosures: Sarah West, None

SU0176

Evidences That PTH Can Be Directly Involved in the Regulation of the Secreted Frizzled Related Proteins (sFRPs) And The Wnt Signaling Pathway Natalia Carrillo-Lo´pez*1, Lucı´a Martı´n-Gutie´rrez1, Pablo Roma´n-Garcı´a1, Sara Panizo1, Manuel Naves-Dı´az 1, Jorge Cannata Andia2. 1Bone & Mineral Research Unit. Hospital Universitario Central de Asturias. Instituto Reina Sofı´a de Investigacio´n. REDinREN del ISCIII. Universidad de Oviedo. Oviedo, Asturias, Spain, 2Hospital Universitario Central de Asturias, Spain Disclosures: Natalia Carrillo-Lo´pez, None

SU0177

Role of Akt-eNOS Signal Pathway in the Endothelial Dysfunction induced by Chronic Kidney Disease with Hyperphosphatemia. Tan Vu Van1, Yutaka Taketani*1, Eriko Watari1, Tomoyo Kitamura1, Ken-Ichi Miyamoto 2, Hironori Yamamoto3, Eiji Takeda4. 1University of Tokushima, Japan, 2 Tokushima University School of Medicine, Japan, 3University Tokushima, Japan, 4 University of Tokushima School of Medicine, Japan Disclosures: Yutaka Taketani, None

DISORDERS OF MINERAL METABOLISM: RHEUMATOLOGIC AND OTHER SYSTEMIC ILLNESSES SU0178

Adipocytokines Affect the Bone Metabolism of Rheumatoid Arthritis PatientsTOMORROW study Yuko Sugioka*, Tadashi Okano, Masahiro Tada, Tatsuya Koike. Osaka City University Medical School, Japan Disclosures: Yuko Sugioka, None

SU0179

Bariatric Surgery Results in Significant Loss of Cortical Bone Emily Stein* 1, Polly Chen2, Angela Carrelli3, Donald McMahon1, Kavita Pandit2, Marc Bessler2, Beth Schrope2, Elizabeth Shane1, Shonni Silverberg2. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University, USA, 3New York Presbyterian- Columbia University, USA Disclosures: Emily Stein, None

158

SU0180

Expression of DKK-1 and Sclerostin in Osteoarthritis Allahdad Zarei*1, Cyrus Cooper2, Muhammad Javaid3, Afsie Sabokbar4. 1Botnar Research Centre, University of Oxford, United Kingdom, 2University of Southampton, United Kingdom, 3University of Oxford, United Kingdom, 4University of Oxford, Botnar Research Centre, United Kingdom Disclosures: Allahdad Zarei, None

SU0181

Long Term Anti TNFa Therapy for Inflammatory Rheumatic Disease is Associated with Increased Bone Mineral Density and Paradoxical Elevation of TRAP5b Serum Levels Eric Toussirot*1, Laurent Mourot2, Emilie Grandclement3, Daniel Wendling4, Gilles Dumoulin 5. 1University Hopsital J Minjoz, France, 2EA3920 Physiopathologie Cardiovasculaire et Pre´vention, France, 3Explorations fonctionnelles et biochimie endocrinienne et me´tabolique, France, 4University Hospital Minjoz, France, 5Explorations fonctionnelles et biochimie hormonale et me´tabolique, France Disclosures: Eric Toussirot, None

DISORDERS OF MINERAL METABOLISM: TRANSPLANTATION SU0182

Safety of High Dose Vitamin D Therapy in Lung Transplant Recipients Caroline Ball*1, Daniel Dilling2, Charles Alex2, Pauline Camacho3. 1Loyola University Chicago Stritch School of Medicine, USA, 2Loyola University Medical Center, USA, 3 Loyola University of Chicago, USA Disclosures: Caroline Ball, None

DISORDERS OF MINERAL METABOLISM: VASCULAR AND ECTOPIC CALCIFICATION SU0183

Cell Density Governs Self-Organization into Patterns in Calcifying Vascular Cells Henry Cheng*1, Aneela Reddy1, Andrew Sage 2, Alan Garfinkel1, Yin Tintut1, Linda Demer3. 1University of California, Los Angeles, USA, 2University of Cambridge, United Kingdom, 3David Geffen School of Medicine At University of California Los Angeles, USA Disclosures: Henry Cheng, None

SU0184

Disclosures: S. Jeffrey Dixon, None SU0185

Severe Skeletal Toxicity from Protracted Etidronate Therapy for Generalized Arterial Calcification of Infancy (GACI) Gary S. Gottesman*1, Jesse E. Otero2, William H. McAlister3, Katherine L. Madson1, Steven Mumm4, Michael P. Whyte4. 1Shriners Hospital for Children, St. Louis, USA, 2 Washington University in St. Louis School of Medicine, USA, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, USA, 4Shriners Hospital for Children & Washington University School of Medicine, St. Louis, USA Disclosures: Gary S. Gottesman, None

SU0186

The Role of ApoE/Lrp5/6 in Aortic Valve Calcification: LDL-Density-Pressure Theory Nalini Rajamannan*. Northwestern University Medical School, USA Disclosures: Nalini Rajamannan, None

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: GENE THERAPY SU0187

Application of iPS Cells to the Research of Fibrodysplasia Ossificance Progressiva Yoshihisa Matsumoto* 1, Makoto Ikeya2, Akira Nasu2, Isao Asaka2, Takanobu Otsuka3, Edward Hsiao4, Junya Toguchida2. 1Department of Cell Growth & Differentiation, Center for iPS Cell Research & Application, Kyoto University, Department of Orthopedic Surgery, Graduate School of Medicine, Nagoya City University, Japan, 2Department of Cell Growth & Differentiation, Center for iPS Cell Research & Application, Kyoto University, Japan, 3Department of Orthopedic Surgery, Graduate School of Medicine, Nagoya City University, Japan, 4Gladstone Institute of Cardiovascular Disease, USA Disclosures: Yoshihisa Matsumoto, None

159

Sunday

Loss of Equilibrative Nucleoside Transporter 1 (ENT1) Leads to Progressive Hypermineralization of Paraspinal Tissues: A Novel Murine Model Resembling Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Humans Derek Bone, Sumeeta Warraich, Diana Quinonez, David Holdsworth, S. Jeffrey Dixon*, Cheryle Se´guin, James Hammond. The University of Western Ontario, Canada

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: GENERAL STUDIES SU0188

A Transcriptomic Analysis of Type II Autosomal Dominant Osteopetrosis Osteoclasts : Identification of New Disease Markers Amelie COUDERT*1, Robert OLASO2, Corinne COLLET1, Marie-Christine De Vernejoul 3. 1INSERM, France, 2CEA, France, 3Fe´de´ration De Rhumatologie Et INSERM U606, France Disclosures: Amelie COUDERT, None

SU0189

Altered Transcript Pattern During Osteoblast Differntiation Associated With Improved Bone Phenotype In Homozygous Osteogenesis Imperfecta Brtl Mice ADI REICH*, Wayne A. Cabral, Joan Marini. National Institute of Child Health & Human Development, USA Disclosures: ADI REICH, None

SU0190

Fragility Fracture Family History and Rate of Bone Loss—Volumetric Cancellous Spinal Bone Change in Premenopausal Women Jerilynn Prior*1, Christine Hitchcock1, Yvette Vigna1, Vanadin Seifert-Klauss 2. 1University of British Columbia, Canada, 2Technical University of Munich, Germany Disclosures: Jerilynn Prior, None

SU0191

Heterozygous Carriers of the SOST Mutation Demonstrate Reduced Sclerostin and Increased P1NP Concentrations Antoon Van Lierop*1, Herman Hamersma 2, Neveen Hamdy1, Socrates Papapoulos1. 1 Leiden University Medical Center, The Netherlands, 2Flora Clinic, Department of EarNose-and_Throat, South Africa Disclosures: Antoon Van Lierop, None

SU0192

Histidine Decarboxylase is a Candidate Gene for a Quantitative Trait Locus Affecting Peak Bone Density and Strength in Mice Robert Klein*1, Emily Larson2, Wendy Wagoner2, Amy Carlos2, Terry Morgan2. 1 Portland VA Medical Center, USA, 2Oregon Health & Science University, USA Disclosures: Robert Klein, None

SU0193

Microarray-based Copy Number Analysis Can Identify Genomic Disruptions of PHEX Causing X-linked Hypophosphatemic Rickets Steven Mumm* 1, Deborah Wenkert2, Margaret Huskey3, Valerie A. Wollberg2, Michael P. Whyte1. 1Shriners Hospital for Children & Washington University School of Medicine, St. Louis, USA, 2Shriners Hospital for Children, St. Louis, USA, 3Washington University in St. Louis School of Medicine, USA Disclosures: Steven Mumm, Shriners Hospital for Children, 2

SU0194

Osteoporosis Pseudoglioma Syndrome (OPPG): Severity of abnormal bone geometry varies with genotype Sheila Ramirez 1, Mary Leonard2, Rita Herskovitz 2, Elizabeth Streeten*3. 1University of Maryland, Endocrinology, USA, 2Children’s Hospital of Philadelphia, USA, 3University of Maryland School of Medicine, USA Disclosures: Elizabeth Streeten, None

SU0195

Possible Hypophosphatasia in Personalized Medicine Research Project Less Shrestha*1, Fergus McKiernan1, Richard Berg 2, Jay Fuehrer2. 1Marshfield Clinic, USA, 2Medical Bioinformatics, Marshfield Clinic Research Foundation, USA Disclosures: Less Shrestha, None

160

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: LINKAGE STUDIES AND POLYMORPHISMS SU0196

A Novel Gain-of-Function Mutation of the Calcium-Sensing Receptor Gene, CaSR D410E might be associated with Autosomal Dominant Hypocalcemia: A Series of Korean Hypopara Registry Study (2) Byoungho Choi*1, Young Mi Kim2, Yoon-Sok Chung3, Tae Sik Jung4, Chul Hoon Kim5, Suntaek Hong2, Sihoon Lee 1. 1Gachon University School of Medicine, South Korea, 2 Gachon University of Medicine & Science, South Korea, 3Ajou University School of Medicine, South Korea, 4Gyeongsang National Universty School of Medicine, South Korea, 5Yonsei University College of Medicine, South Korea Disclosures: Byoungho Choi, None

SU0197

A Novel Non-synonymous Coding Variant in the Frizzled-1 Gene is Associated with Enhanced Activation of the Canonical Wnt Signaling Pathway. Yingze Zhang*1, Shibing Yu2, Allison Kuipers3, Yanxia Chu1, Cara Nestlerode1, Joseph Zmuda3. 1University of Pittsburgh, USA, 2University of Pittsburgh Medical Center, USA, 3 University of Pittsburgh Graduate School of Public Health, USA Disclosures: Yingze Zhang, None

SU0198

A Variant Near RUNX2 Is Associated with BMD and Cartilage Thickness Martha Castano-Betancourt*1, Karol Estrada2, Hanneke Kerkhof3, Albert Hofman4, Andre Uitterlinden 5, Fernando Rivadeneira2, Joyce Van Meurs6, GEFOS Consortium3. 1 Erasmus MC, The Netherlands, 2Erasmus University Medical Center, The Netherlands, 3 Internal Medicine, Erasmus MC, Netherlands, 4Department of Epidemiology, Erasmus MC, Netherlands, 5Rm Ee 575, Genetic Laboratory, The Netherlands, 6Erasmus Medical Center, The Netherlands Disclosures: Martha Castano-Betancourt, None

SU0199

Genetic Control of Ca Absorption and BMC Differs Dependent on Dietary Calcium (Ca) Rebecca Replogle*1, Libo Wang2, Min Zhang2, James Fleet1. 1Purdue University, USA, 2 Purdue University Dept. of Statistics, USA Disclosures: Rebecca Replogle, None

GROWTH FACTORS AND CYTOKINES: BONE MORPHOGENETIC PROTEINS Casein Kinase II Activates Bone Morphogenetic Protein Receptor Type Ia in the Absence of Bone Morphogenetic Protein 2 Driving Osteoblast Differentiation Beth Bragdon*1, Oleksandra Moseychuk 2, Lauren Gurski2, Hemanth Akkiraju2, Jeremy Bonor2, Anja Nohe2. 1University of Maine, University of Delaware, USA, 2University of Delaware, USA Disclosures: Beth Bragdon, None SU0201

Wnt3a Stimulates Bmp2 Expression in Osteogenic Cells that Are Epigenetically Ready Young-Dan Cho*1, Woo-Jin Kim1, Won-Joon Yoon1, Kyung Mi Woo1, Jeong-Hwa Baek2, Hyun-Mo Ryoo1. 1Seoul National University, School of Dentistry, South Korea, 2 Seoul National University School of Dentistry, South Korea Disclosures: Young-Dan Cho, None

GROWTH FACTORS AND CYTOKINES: FIBROBLAST GROWTH FACTORS SU0202

Expression of Subtilisin-like Proprotein Convertases (PCSKs) in FGF23 Producing Extravillous Trophoblast of Human Placenta Masanori Takaiwa*1, Koji Kadoya2, Kosei Hasegawa 3, Kunihiko Aya3, Hiroyuki Tanaka4, Tsuneo Morishima3, Motofumi Yokoyama5, Youichi Kondo1, Nobuyuki Kodani1. 1Dept. of Pediatrics, Matsuyama Red Cross Hosp., Japan, 2Dept. of Pathology, Matsuyama Red Cross Hosp., Japan, 3Dept. of Pediatrics, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 4Okayama Saiseikai General Hospital, Japan, 5Dept. of Obstetrics & Gynecology, Matsuyama Red Cross Hosp., Japan Disclosures: Masanori Takaiwa, None

161

Sunday

SU0200

SU0203

Osteostatin Improves the Osteogenic Capacity of Fibroblast Growth Factor-2 Coated onto SiDoped Hydroxyapatite in Osteoblastic Cells Daniel Lozano*1, MJ Feito 2, Sergio Portal-Nu´n˜ez1, RM Lozano3, MC Serrano4, M ValletRegı´5, MT Portole´s 6, Pedro Esbrit7. 1Instituto de Investigacio´n Sanitaria-Fundacio´n Jime´nez Dı´az, Spain, 2Dpto. de Bioquı´mica y Biologı´a Molecular I, UCM, Spain, 3Centro de Investigaciones Biolo´gicas, CSIC, Spain, 4Instituto de Ciencia de Materiales, CSIC, Spain, 5Departamento de Quı´mica Inorga´nica y Bioinorga´nica, UCM, Spain, 6 Departamento de Bioquı´mica y Biologı´a Molecular I, UCM, Spain, 7FUNDACION JIMENEZ DIAZ, Spain Disclosures: Daniel Lozano, None

GROWTH FACTORS AND CYTOKINES: GENERAL SU0204

A Reappraisal of the Skeletal Phenotype of Leptin Signaling-Deficient Mice: Implications for the Physiological Role of Leptin as a Regulator of Bone Metabolism Russell Turner*1, Kenneth Philbrick 1, Satya P. Kalra2, Urszula Iwaniec1. 1Oregon State University, USA, 2University of Florida McKnight Brain Institute, USA Disclosures: Russell Turner, None

SU0205

Acerogenins, a Natural Compound Isolated from Acer nikoense Maxim, Stimulates Osteoblast Differentiation through Bone Morphogenetic Protein Action Ji-Won Lee*1, Takayuki Yonezawa2, Tasuku Kihara1, Hiroyuki Akazawa3, Toshihiro Akihisa3, Akira Yamaguchi 4, Je-Tae Woo5. 1Section of Oral Pathology, Graduate School of Medical & Dental Sciences, Tokyo Medical & Dental University, Japan, 2The University of Tokyo, Japan, 3College of Science & Technology, Nihon University, Japan, 4Tokyo Medical & Dental University, Japan, 5Research Institute for Biological Functions, Chubu University, Japan Disclosures: Ji-Won Lee, None

SU0206

Divergent Effects of Partial (ob/+) and Complete (ob/ob) Loss of Leptin Production on Cortical Bone Kenneth Philbrick*, Russell Turner, Urszula Iwaniec. Oregon State University, USA Disclosures: Kenneth Philbrick, None

SU0207

Immune Cell Populations, Severely Compromised Following Long Term High Fat Diet, Are Partially Restored by Low Intensity Mechanical Signals Ete Meilin Chan*1, Benjamin Adler1, Danielle Green1, Ada H. Tsoi1, Mario E. Botros1, Clinton Rubin2. 1STONY BROOK UNIVERSITY, USA, 2State University of New York at Stony Brook, USA Disclosures: Ete Meilin Chan, None

SU0208

Interferon c Inhibits Bone Marrow Adipogenesis Sandra Bermeo-Serrato*1, Christopher Vidal2, Lee Wei Li3, Dao Chao Huang4, Richard Kremer5, Gustavo Duque6. 1Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Australia, 2University of Sydney, Australia, 3University of Sydney, Nepean Clinical School, Australia, 4McGill University Royal Victoria Hospital, Canada, 5McGill University, Royal Victoria Hospital, Canada, 6Ageing Bone Research Program, University of Sydney, Australia Disclosures: Sandra Bermeo-Serrato, None

SU0209

Lipoteichoic Acid from Enterococcus faecalis Induces Chemokine Expression in Murine Macrophages via Toll-like Receptor 2/CD14/MyD88 Signaling Pathways Ok-Jin Park*1, Ji Young Han2, Jung Eun Baik 2, Seulggie Choi2, Jun Ho Jeon3, Cheol-Heui Yun3, Hong-Hee Kim4, Seung Hyun Han1. 1School of Dentistry, Seoul National University, South Korea, 2Department of Oral Microbiology & Immunology, DRI, & BK21 Program, School of Dentistry, Seoul National University, South Korea, 3Department of Agricultural Biotechnology & Research Institute for Agriculture & Life Sciences, Seoul National University, South Korea, 4Seoul National University, South Korea Disclosures: Ok-Jin Park, None

SU0210

Nalp3 Inflammasome Activation Mediates Peri-implant Osteolysis Ed Purdue*, Nikolaus Binder, Krista Bohnert, Bryan Nestor, Thomas Sculco, F. Patrick Ross, Steven Goldring. Hospital for Special Surgery, USA Disclosures: Ed Purdue, None

162

SU0211

Platelet-derived Growth Factors (PDGFs) Functions in Tooth Development YU SUGAWARA*, Tsutomu Iwamoto, Masaharu Futagi, Mariko Ono, Aya Yamada, Takashi Nakamura, Satoshi Fukumoto. Tohoku University Graduate School of Dentistry, Japan Disclosures: YU SUGAWARA, None

SU0212

PTH Stimulates Osteoblastic VEGF-A Expression in a Differentiation-Dependent Manner Julianne Smith*1, Jonathan Weber1, Laura Calvi 2. 1University of Rochester School of Medicine & Dentistry, USA, 2University of Rochester School of Medicine, USA Disclosures: Julianne Smith, None

SU0213

Synergistic Effects of Oncostatin M and IL-1b in an Arthritic Chondrocyte Model Liliana Mellor*, Cheryl Jorcyk, Julia Oxford. Boise State University, USA Disclosures: Liliana Mellor, None

SU0214

System Engineering Approach to Optimize the Multi-cofactor Combination of Osteogenic Cocktail with Minimized BMP-2 Doses Yoshitomo Honda*1, Xianting Ding 2, Federico Mussano3, Akira Wiberg4, Chih-ming Ho2, Ichiro Nishimura 5. 1UCLA / Tohoku University, USA, 2Department of Mechanical & Aerospace Engineering, Center for Cell Control, UCLA, USA, 3UCLA School of Dentistry and University of Turin, Italy, USA, 4 The Weintraub Center for Reconstructive Biotechnology,UCLA school of Dentistry, USA, 5University of California, Los Angeles, USA Disclosures: Yoshitomo Honda, None

SU0215

The Level of Osterix Expression in Bone Is Important to Prevent Chronic Inflammation Wook-Young Baek*1, Eun-Hye Lee 1, Tae-Hwan Kwon2, Kwon-Moo Park3, Jung-Eun Kim4. 1Cell & Matrix Research Institute, Department of Molecular Medicine, Kyungpook National University School of Medicine, South Korea, 2Cell & Matrix Research Institute, Department of Biochemistry & Cell Biology, Kyungpook National University School of Medicine, South Korea, 3Department of Anatomy, Kyungpook National University School of Medicine, South Korea, 4Kyungpook National University School of Medicine, South Korea Disclosures: Wook-Young Baek, None

SU0216

New Mechanisms Accounting for a Fine Tuning Regulation of Osteoblast and Osteoclast Activity Barbara Peruzzi*1, Alfredo Cappariello2, Andrea Del Fattore2, Nadia Rucci 1, Fabrizio De Benedetti 2, Anna Teti1. 1University of L’Aquila, Italy, 2Ospedale Pediatrico Bambino Gesu`, Italy Disclosures: Barbara Peruzzi, None

OSTEOBLASTS: APOPTOSIS AND CELL CYCLE SU0217

Aptamer-Functionalized Stable Nucleic Acid Lipid Particles for siRNA Cell-specific Delivery to Osteoblast Cells Heng WU*1, Tao Tang1, Baosheng Guo 2, Baoting Zhang3, Zhijun YANG4, Leungkim HUNG5, Ningsheng SHAO6, Lingqiang ZHANG7, Ling Qin8, Ge Zhang9. 1The Chinese University of Hong Kong, Hong Kong, 2Prince of Wales Hospital, Hong Kong, 3Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, 4Hong Kong Baptist University, China, 5The Chinese University of Hong Kong, China, 6Beijing Institute of Basic Medical Sciences, China, 7Beijing Institute of Radiation Medicine, China, 8Chinese University of Hong Kong, Hong Kong, 9Prince of Wales Hospital, Hong Kong Disclosures: Heng WU, None

SU0218

Deficiency of Bax Expression Prevents Diabetes-induced Osteoblast Death and Bone Loss Lindsay Martin-Coe* 1, Laura McCabe2. 1New York University College of Dentistry, USA, 2 Michigan State University, USA Disclosures: Lindsay Martin-Coe, None

163

Sunday

GROWTH FACTORS AND CYTOKINES: INSULIN-LIKE GROWTH FACTORS AND BINDING PROTEINS

SU0219

Vitamin C Administration Markedly Ameliorates Bone loss by Restoring the Osteoblastic Viability in Sod1-deficient Mice Hidetoshi Nojiri*1, Yoshitomo Saita2, Daichi Morikawa3, Keiji Kobayashi4, Mitsuru Saito5, Kazuo Kaneko6, Takahiko Shimizu7. 1Juntendo University, School of Medicine, Japan, 2Department of Orthopaedics, Juntendo University School of Medicine, Japan, 3 Juntendo Univerisity, Japan, 4Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan, 5Jikei University School of Medicine, Japan, 6Department of Orthopaedics, Juntendo University, Japan, 7Tokyo Metropolitan Institute of Gerontology, Japan Disclosures: Hidetoshi Nojiri, None

OSTEOBLASTS: BONE FORMATION AND BONE RESORPTION SU0220

Angiotensin II induces osteoblast production of MMP-3 and MMP-13 via the AT1 receptor Kumiko Nakai*1, Takayuki Kawato2, Masafumi Motohashi3, Masao Maeno4. 1Division of Oral Health Sciences, Japan, 2Nihon University School of Dentistry, Tokyo, Japan, Japan, 3 Department of Oral Health Sciences, Nihon University School of Dentistry, Japan, 4Nihon University School of Dentistry, Japan Disclosures: Kumiko Nakai, None

SU0221

Bone Size QTL Gene Located in Mouse Chromosome 4 is a Mechanoresponsive Gene Jon Wergedal*, Chandrasekhar Kesavan, Subburaman Mohan. Jerry L. Pettis Memorial VA Medical Center, USA Disclosures: Jon Wergedal, None

SU0222

Clopidogrel (PlavixH), a P2Y12 Receptor Antagonist, Inhibits Osteoblast Function in vitro and Decreases Trabecular Bone in vivo Isabel Orriss*1, Susanne Syberg2, Andrea Brandao-Burch1, Mark Hajjawi1, Timothy Arnett3, Peter Schwarz4, Niklas Jorgensen5. 1University College London, United Kingdom, 2 Copenhagen University Hosptial Glostrup, Denmark, 3University College, London, United Kingdom, 4Glostrup Hospital, Denmark, 5Copenhagen University Hospital Glostrup, Denmark Disclosures: Isabel Orriss, None

SU0223

Deregulation of Wnt Signaling in the Fracture Callus Following Binge Alcohol Exposure is Attenuated by Lithium Chloride Treatment Kristen Lauing*1, Philip Roper2, Rachel Nauer3, John Callaci4. 1Loyola University Medical Center, USA, 2Loyola University Medical Center, Cell Biology, Neurobiology, & Anatomy Program, USA, 3Loyola University Medical Center, Department of Orthopaedic Surgery, USA, 4Loyola University of Chicago, USA Disclosures: Kristen Lauing, None

SU0224

Effects of Focused Shock Wave (FSW) on Cementoblasts in vitro Dawei Liu*. Marquette University School of Dentistry, USA Disclosures: Dawei Liu, None

SU0225

Hairy and Enhancer of Split Related with YRPW Motif (Hey)2 Uncouples Bone Formation from Bone Resorption. Stefano Zanotti*, Ernesto Canalis. St. Francis Hospital & Medical Center, USA Disclosures: Stefano Zanotti, None

SU0226

Heparanase is a Physiologic Regulator of Bone Formation and Bone Mass Vardit Kram*1, Eyal Zcharia2, Orr Ofek1, Alon Bajayo3, Malka Attar-Namdar1, Yoav Smith1, Jin-Ping Li 4, Israel Vlodavsky2, Itai Bab5. 1Hebrew University of Jerusalem, Israel, 2 Technion, Israel, 3Hebrew University, Faculty of Dentistry, Israel, 4Uppsala University, Sweden, 5The Hebrew University, Israel Disclosures: Vardit Kram, None

SU0227

Mechanism of Formation of Novel Bone Forming Cells (monoosteophils) from LL-37 Treated Monocytes. Zhifang Zhang*1, John Shively2. 1City of hope, USA, 2Department of Immunology, City of Hope, USA Disclosures: Zhifang Zhang, None

164

SU0228

Neuropeptide Y1 Receptor Antagonist Reduces Periosteal Bone Formation and Mitigates the Bone Response to Mechanical Loading Edith Gardiner*1, Leah Worton2, Steven Bain1, Ted Gross 1, Sundar Srinivasan1. 1 University of Washington, USA, 2The University of Washington, USA Disclosures: Edith Gardiner, None

SU0229

Opto-Functional Control of Intracellular RANKl Transport/Secretion in Osteoblasts to Enhance Coupling With Osteoclasts Based on Photo-Energy Conversion of MolecularlyEngineered Channel-Rhodopsin Takuya Notomi*1, Miyuki Kuno2, Yoichi Ezura3, Masaki Noda4. 1GCOE, Tokyo Medical & Dental University, Japan, 2Osaka City University, Japan, 3Tokyo Medical & Dental University, Medical Research Insititute, Japan, 4Tokyo Medical & Dental University, Japan Disclosures: Takuya Notomi, None

SU0230

Osteoblastic Wnts Regulate Postnatal Bone Remodeling through Maintaining BMSC and Inhibiting Inflammation Wan Yong*1, Cheng Lu2, Jingjing Cao2, Zhengju Yao3, Gang Ma 1, Xizhi Guo1. 1Shanghai Jiao Tong University, Peoples Republic of China, 2colleague, China, 3mentor, China Disclosures: Wan Yong, None

SU0231

PTH1r and 5HT1b Receptors are Involved in Mediating the Action of n-3 Fatty Acids in Bone Cells Hesam Tavakoli, Jose Candelario, Mirianas Chachisvilis*. La Jolla Bioengineering Institute, USA Disclosures: Mirianas Chachisvilis, None

SU0232

Recombinant Activated Protein C Stimulates Bone Nodule Formation and Osteocalcin Expression in Osteoblasts Kaitlin Shen*1, Benjamin Chan2, Meilang Xue3, Colin Dunstan4, Hala Zreiqat4, Christopher Jackson3. 1Kolling Institute of Medical Research, University of Sydney, Australia, 2Royal North Shore Hospital, Australia, 3Kolling Institute of Medical Research, Australia, 4University of Sydney, Australia Disclosures: Kaitlin Shen, None

SU0233

Disclosures: Ippei Kanazawa, None SU0234

Resolution of Inflammation Modulates Wnt Signaling and Promotes Osteoblast-mediated Erosion Repair in Inflammatory Arthritis Melissa Matzelle*1, Maxime Gallant2, Keith Condon2, Nicole Walsh3, Catherine Manning1, Jane Lian 1, David Burr2, Ellen Gravallese1. 1University of Massachusetts Medical School, USA, 2Indiana University School of Medicine, USA, 3St Vincent’s Institute of Medical Research, Australia Disclosures: Melissa Matzelle, Abbott Bioresearch Center, 99

SU0235

Runx2 Promotes both Osteoblastogenesis and Novel Osteoclastogenic Signals in ST2 Mesenchymal Progenitor Cells Sanjeev Baniwal*1, Parantu K. Shah2, Yunfan Shi3, Josephine Haduong4, Yves DeClerck3, Yankel Gabet5, Baruch Frenkel1. 1University of Southern California, USA, 2Dana-Farber Cancer Institute, Harvard School of Public Health, USA, 3Keck School of Medicine, University of Southern California, USA, 4Keck School of Medicine, Unievrsity of Southern California, USA, 5Tel Aviv University, Israel Disclosures: Sanjeev Baniwal, None

SU0236

Sef (IL17RD) is a Negative Regulator of Osteogenic Differentiation and Bone Formation Qing He*1, Xuehui Yang2, Robert Friesel 2. 1Maine Medical Center - Hospital, USA, 2 Maine Medical Center Research Institute, USA Disclosures: Qing He, None

165

Sunday

Reduced Accumulation of Bone in Mice Lacking the Men1 Gene in Osteoblasts Ippei Kanazawa*1, Geeta Nayak2, Lucie Canaff1, Monzur Murshed1, Geoffrey Hendy3. 1 McGill University, Canada, 2McGill Unversity, Canada, 3McGill University, Royal Victoria Hospital, Canada

SU0237

TRPV4 Deficiency Suppresses Fluid Flow Induced Activation of Calcium Oscillation in a Manner Dependent on Osteoblastic Differentiation Takafumi Suzuki*1, Takuya Notomi2, Daisuke Miyajima1, Yoichi Ezura3, Tetsuya Nakamoto 1, Tadayoshi Hayata4, Atsuko Mizuno5, Makoto Suzuki6, Fumitaka Mizoguchi 1, Yuichi Izumi7, Masaki Noda1. 1Tokyo Medical & Dental University, Japan, 2 GCOE, Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Medical Research Insititute, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5Jichi Medical University, Japan, 6Department of Pharmacology, Jichi Medical School, Japan, 7Department of periodontology, Japan Disclosures: Takafumi Suzuki, None

OSTEOBLASTS: GENE EXPRESSION AND TRANSCRIPTION FACTORS SU0238

Age Related Changes in FGF2 and Beta-Catenin Expression in Osteoblasts from Young, Middle Aged and Elderly Female Patients Marja Marie Hurley*1, Alycia Esliger2, Liping Xiao2, Gloria Gronowicz 2. 1University of Connecticut Health Center School of Medicine, USA, 2University of Connecticut Health Center, USA Disclosures: Marja Marie Hurley, None

SU0239

Differential activation of the Alkaline Phosphatase promoter by pRB and p107 Stephen Flowers*1, Elizabeth Moran2. 1NJMS-UH Cancer Center, University of Medicine of Dentistry of New Jersey, USA, 2University of Medicine & Dentistry of New Jersey, Cancer Center, USA Disclosures: Stephen Flowers, None

SU0240

ER Membrane Bound Transcription Factor ATF6 Is Involved in BMP2-induced Osteoblast Differentiation and Osteocalcin Transcription in MC3T3E1 Cells Won Gu Jang1, Eun Jung Kim 1, In Hong Kang*2, Keun-Bae Lee 1, Hueng-Sik Choi1, Jeong-Tae Koh 1. 1Chonnam National University, South Korea, 2Interdisciplinary graduate program in molecular medicin, South Korea Disclosures: In Hong Kang, None

SU0241

Frizzled 1 Promoter Activity and Expression Is Regulated by E2F1 in Osteoblasts Shibing Yu*1, Laura Yerges-Armstrong2, Yanxia Chu3, Joseph Zmuda 4, Yingze Zhang5. 1 University of Pittsburgh Medical Center, USA, 2University of Maryland, USA, 3 University of Pittsburgh,Department of Medicine, USA, 4University of Pittsburgh,Department of Epidemiology, USA, 5University of Pittsburgh, USA Disclosures: Shibing Yu, None

SU0242

Identification of a Small Molecule Kinase Inhibitor That Enhances Osteoblastic Differentiation and In Vivo Bone Formation of Human Skeletal (Mesenchymal) Stem Cells Through Regulation of BMP Signaling Abbas Jafari*1, Basem Abdallah2, Diyako M. Qanie3, Li Chen 4, Nicholas Ditzel4, Moustapha Kassem4. 1University of Southern Denmark, Denmark, 2Odense University Hospital, University of South Denmark, Denmark, 3Institute of Clinical Research, University of Southern Denmark, Denmark, 4Odense University Hospital, Denmark Disclosures: Abbas Jafari, None

SU0243

Iron Decreases Osteoblastic Activity in Human MG 63 Cells Mathilde Doyard*, Nadia Fatih, Marie-Laure Island, Patricia Leroyer, Ge´rard Chale`s, Olivier Lore´al, Pascal Guggenbuhl. INSERM UMR 991, e´quipe Fer et foie : aspects physiologiques et pathologiques, Univ Rennes, France Disclosures: Mathilde Doyard, None

SU0244

Mannosyltransferase Alg2 Is a downstream Regulator of Schnurri-3 in Osteoblast Differentiation Katsuyuki Imamura*1, Yasuhiro Ishidou1, Ichiro Kawamura2, Masahiro Yokouchi1, Setsuro Komiya1, Shingo Maeda3. 1Graduate School of Medical & Dental Sciences, Kagoshima University, Japan, Japan, 2Dept. of Orthopaedic Surgery Kagoshima University, Japan, 3Graduate School of Medical & Dental Sciences, Kagoshima University, Japan Disclosures: Katsuyuki Imamura, None

166

SU0245

NR2C2 Gene Regulated Osteoblasts Bone Formation Activity through Runx2 Stability Shen-chin Hsu*1, Hsin Chiu Ho2, Huei-Ju Ting2, Shinjen Lin3, Tian-Fang Li 2, Mo Chen4, Jonathan Holz3, Tzong-Jen Sheu2, J. Edward Puzas5, Min-jon Lin6. 1Chung Shan Medical University Hospital Dept of Pharmacy, Taiwan, 2University of Rochester, USA, 3 Univeristy of Rochester, USA, 4Columbia University, USA, 5University of Rochester School of Medicine, USA, 6Chung Shan Medical University Dept of Biomedical Sciences, Taiwan Disclosures: Shen-chin Hsu, None

SU0246

Osteogenic Potential of Human Mesenchymal Stem Cells: Role of Specific Transcription Factors and Different Cell Culture Conditions Elena Torreggiani*1, Elisabetta Lambertini2, Letizia Penolazzi2, Renata Vecchiatini2, Gina Lisignoli3, Claudio Nastruzzi4, Roberta Piva 2. 1Department of Biochemistry & Molecular Biology, University of Ferrara, Ferrara, Italy; Department of Reconstructive Science, University of Connecticut Health Center, Italy, 2Department of Biochemistry & Molecular Biology, University of Ferrara, Italy, 3Laboratory of Immunorheumatology & Tissue Regeneration, Istituto Ortopedico Rizzoli, Italy, 4Department of Pharmaceutical Sciences, University of Ferrara, Italy Disclosures: Elena Torreggiani, None

SU0247

Regulation of both Osteoblastic and Myogenic Differentiation by Proteoasome Inhibitor Bortezomib Maki Uyama*, Mari Sato, Masamitsu Kawanami, Masato Tamura. Hokkaido University, Japan Disclosures: Maki Uyama, None

SU0248

The Orphan Nuclear Receptor COUP-TFII Negatively Regulates Osteoblast Differentiation through Inhibiting the Transcriptional Activity of Runx2. Kkot-nim Lee1, Sin-Hye Oh1, Hye-Ju Son2, Won Gu Jang2, In-Hong Kang2, Sun-Hun Kim2, Shee-Eun Lee 2, Jeong-Tae Koh*2. 1Chonnam National University School, South Korea, 2Chonnam National University, South Korea Disclosures: Jeong-Tae Koh, None

SU0249

Disclosures: Gadi Jogeswar, None SU0250

Toward Understanding the Balance Between Osteoblastogenesis and Adipogenesis in Bone Marrow Microenvironment. Basem Abdallah*1, Moustapha Kassem2. 1Odense University Hospital, University of South Denmark, Denmark, 2Odense University Hospital, Denmark Disclosures: Basem Abdallah, None

OSTEOBLASTS: HORMONAL REGULATION AND SIGNAL TRANSDUCTION SU0251

A Novel Mechanism of Signal Transduction: Oxytocin Receptors Activated by the Ligand Translocate in the Nucleus to Enhance Osteoblast Specific Transcription Adriana Di Benedetto 1, Stefania Dell’Endice2, Graziana Colaianni 1, Roberto Tamma2, Concetta Cuscito2, Bice Nico 2, Bice Chini3, Damiana Calvano4, Carlo Zambonin4, Li Sun5, Mone Zaidi 6, Alberta Zallone* 1. 1University of Bari Medical School, Italy, 2Human Anatomy & Histology, University of Bari, Italy, Italy, 3Neuroscience, CNR, Milan, Italy, Italy, 4Department of Chemistry, University of Bari, Italy, Italy, 5Mount Sinai School of Medicine, USA, 6Mount Sinai Medical Center, USA Disclosures: Alberta Zallone, None

167

Sunday

The Transcription Factor Sox11 is Essential for the Early Osteoblast Development Gadi Jogeswar*1, Kwang Joon Kim2, Ajita Jami3, Kyoung Min Kim2, Hoon Choi4, SungKil Lim2. 1Yonsei University College of Medicine Seoul South Korea, South Korea, 2 Division of Endocrinology & Endocrine Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, South Korea, 3Brain Korea 21 Project for medical sciences, Yonsei University College of Medicine, Seoul, Republic of Korea-120 752, South Korea, 4Inje University Sanggyepaik Hospital, South Korea

SU0252

Angiotensin II regulates RANKL:OPG ratio potentially through transactivation of ErbB receptors by EGF-like ligands Kirsty MacRae* 1, Conrad Sernia2, Walter Thomas3. 1University of Queensland, Australia, 2 Associate Professor, Australia, 3Professor, Australia Disclosures: Kirsty MacRae, None

SU0253

Duality of TRIP-1 Function in Regulating Osteoblast Activity In Vitro Diana Metz-Estrella*1, Tzong-Jen Sheu1, J. Edward Puzas2. 1University of Rochester, USA, 2University of Rochester School of Medicine, USA Disclosures: Diana Metz-Estrella, None

SU0254

Impaired Osteoblast Differentiation and PTH Response in Female Mice Lacking MAP Kinase Phosphatase-1 Chandrika Mahalingam1, Tanuka Datta1, Rashmi Patil1, Jaclynn Kreider2, Steven Goldstein 2, Abdul Abou-Samra1, Nabanita Datta*1. 1Wayne State University School of Medicine, USA, 2University of Michigan, USA Disclosures: Nabanita Datta, None

SU0255

Metabolic Acidosis-induced Stimulation of RANKL and Bone Resorption Requires Gbc Signaling Nancy Krieger*1, Christopher Culbertson2, David Bushinsky1. 1University of Rochester, USA, 2Universitiy of Rochester School of Medicine, USA Disclosures: Nancy Krieger, None

SU0256

The Role of Tmem119 in the BMP Signaling Pathway Geoffrey Hendy1, KENICHIRO TANAKA* 2, Lucie Canaff3, Toshitsugu Sugimoto2, Hiroshi Kaji 4, Riko Kitazawa5, Toshihisa Komori6, Susumu Seino7, Takenobu Katagiri8. 1 McGill University, Royal Victoria Hospital, Canada, 2Shimane University School of Medicine, Japan, 3McGill University, Canada, 4Kinki University Faculty of Medicine, Jpn, 5 Kobe University, Japan, 6Nagasaki University Graduate School of Biomedical Sciences, Japan, 7Kobe University Graduate School of Medicine, Japan, 8Saitama Medical University Research Center for Genomic Medicine, Japan Disclosures: KENICHIRO TANAKA, None

OSTEOBLASTS: PROGENITOR AND STROMAL CELLS, PROLIFERATION AND DIFFERENTIATION SU0257

Additive Effects of TBT and TCDD on Bone Cell Differentiation Antti Koskela*1, Juha Tuukkanen1, Matti Viluksela2, Merja Korkalainen2. 1University of Oulu, Finland, 2National Institute for Health & Welfare, Finland Disclosures: Antti Koskela, None

SU0258

Aged Perivascular Mesenchymal Stem Cells Derived from Adipose Tissue are Hyperproliferative and Resistant to the Induction of Osteogenic and Adipogenic Differentiation Matthew Stern*1, Amber Stern2, Christopher Bergman3, Stephen Kritchevsky4, Mark Van Dyke3. 1University of Missouri-Kansas City, USA, 2University of Missouri - Kansas City, USA, 3Wake Forest Institute for Regenerative Medicine, USA, 4Wake Forest Baptist Medical Center, Sticht Center on Aging, USA Disclosures: Matthew Stern, None

SU0259

Biomimetic Calcium Silicate Support Differentiation of Human Orofacial Bone Marrow Stromal Cells Sara Shah1, Maria Giovanna Gandolfi2, Ruoxue Feng1, Carlo Prati2, Sunday Akintoye*3. 1 University of Pennsylvania, USA, 2University of Bologna, Italy, 3University of Pennsylvania School of Dental Medicine, USA Disclosures: Sunday Akintoye, None

168

SU0260

Characterization of Murine Telomerase Reverse Transcriptase (mTERT) Immortalized Osteoblast Cell Lines Generated from Wild-type and Nmp4-null Mouse Bone Marrow Stromal Cells. Marta Alvarez*1, Paul Childress2, Binu Philip2, Rita Gerard-O’Riley2, Michael Hanlon2, Brittney-Shea Herbert2, Alexander Robling3, Fredrick Pavalko2, Joseph Bidwell 2. 1Indiana Univ. School of Medicine, USA, 2Indiana University School of Medicine, USA, 3Indiana University, USA Disclosures: Marta Alvarez, None

SU0261

Differential Effect of Arachidonic Acid and Beta-Cryptoxanthin on the Expression of Retinoic Acid Receptors Genes in Mesenchymal Stem Cells Differentiated to Osteoblasts and Adipocytes Antonio Casado-Dı´az*1, Raquel Santiago-Mora2, Jose Manuel Quesada Gomez3. 1 Hospital Reina Sofı´a, Spain, 2Universidad De Co´rdoba, Spain, 3Gabinete Quesper, Spain Disclosures: Antonio Casado-Dı´az, None

SU0262

Differential Requirement of SWI/SNF Chromatin Remodeling Complexes in Osteoblast Commitment and Differentiation in vitro FUHUA XU*1, Stephen Flowers2, Elizabeth Moran3. 1New Jersey Medical School, UMDNJ, USA, 2NJMS-UH Cancer Center, University of Medicine of Dentistry of New Jersey, USA, 3University of Medicine & Dentistry of New Jersey, Cancer Center, USA Disclosures: FUHUA XU, None

SU0263

Distribution of Neural Crest-Derived Cells in Adult Mice and Their Induction into Osteoblastic Cells Miki Ono*1, Masamichi Takami2, Tetsuo Suzawa2, Tomohiko Miyauchi2, Atsushi Yamada3, Junichi Watahiki2, Kazuyoshi Baba2, Masanori Nakamura 2, Kotaro Maki2, Noriko Osumi4, Ryutaro Kamijo2. 1Departments of Biochemistry, Orthodontics, School of Dentistry, Showa University, Japan, 2Showa University School of Dentistry, Japan, 3Showa University School of Dentistry, Jpn, 4Tohoku University Graduate School of Medicine, Japan Disclosures: Miki Ono, None

SU0264

Disclosures: Benjamin Adler, None SU0265

Stage-specific Embryonic Antigen-4 Identifies Human Dental Pulp Stem Cells Noriaki Kawanabe* 1, Satoko Murata2, Hiroaki Fukushima 2, Yoshihito Ishihara2, Hiroshi Kurosaka 2, Hiroshi Kamioka3, Takashi Yamashiro2. 1Okayama University Hospital, Japan, 2Okayama University, Japan, 3Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sc, Japan Disclosures: Noriaki Kawanabe, None

SU0266

Therapeutic Potential of Glucocorticoid-Induced Leucine Zipper (GILZ) Protein in Rheumatoid Arthritis Linlin He*1, Nianlan Yang1, Carlos Isales2, Xing-Ming Shi 2. 1Georgia Health Sciences University, USA, 2Medical College of Georgia, USA Disclosures: Linlin He, None

SU0267

Treatment of Skeletally Unloaded Mice With Sclerostin Antibody Increases Osteoblast Activity and Mineralization Mohammad Shahnazari* 1, Vivian Chu2, Marina Stolina3, Thomas Wronski4, Hua Zhu Ke5, Bernard Halloran6. 1UCSF VA Medical Center, USA, 2VA Medical Center, USA, 3 Amgen Inc, USA, 4University of Florida, USA, 5Amgen, Inc., USA, 6VA Medical Center (111N), USA Disclosures: Mohammad Shahnazari, Amgen, 2

SU0268

VDR Is Required for Anti-proliferative and Pro-osteoblastogenic Effects of 1,25(OH)2D3 in Adult Human Mesenchaymal Stem Cells Shuo Geng, Shuanhu Zhou*, Julie Glowacki. Brigham & Women’s Hospital, USA Disclosures: Shuanhu Zhou, None

169

Sunday

Hematopoiesis and Leukocyte Distribution Within Bone Marrow Are Rapidly Disrupted by a High Fat Diet, While Daily Bouts of Mechanical Signals Enhance the Hematopoietic Repair Response Benjamin Adler* 1, Danielle Green1, Ete Meilin Chan1, Clinton Rubin2. 1Stony Brook University, USA, 2State University of New York at Stony Brook, USA

SU0269

Zinc Finger Targeting of Promoter-Reporter Constructs to a ‘‘Safe Haven’’ Site in Human Pluripotent Stem Cells to Facilitate Analysis and Therapy of Bone Disease Xiaonan Xin*, Xi Jiang, Liping Wang, Mary Louise Stover, Hui-Chen Chan, Shuning Zhan, I-Ping Chen, Ernst Reichenberger, David Rowe, Alexander Lichtler. University of Connecticut Health Center, USA Disclosures: Xiaonan Xin, None

OSTEOBLASTS: STEROID/SERM EFFECTS SU0270

In Vitro Study on the Estradiol Dependent Changes on the Mechanical and Structural Properties of Human Fetal Osteoblasts cells PADMALOSINI MUTHUKUMARAN*, Chwee Teck LIM, Taeyong Lee. National University of Singapore, Singapore Disclosures: PADMALOSINI MUTHUKUMARAN, None

OSTEOCLASTS: CATHEPSINS AND OTHER PROTEINASES SU0271

Characterization of Six Monoclonal Antibodies to Human Tartrate Resistant Acid Phosphatase (TRACP) Silvia D. Potenziani1, Stephen Slone1, Ranga Parthasarathy2, Yi-Ying Wu 3, Tsu-Yi Chao4, Lung Yam5, Anthony Janckila*6. 1Department of Pathology & Laboratory Medicine, University of Louisville, USA, 2Molecular Neuroscience & Bioinformatics, Robley Rex Louisville VA Medical Center, USA, 3Graduate Institute of Life Sciences, National Defense Medcial Center, Taiwan, 4Department of Medicine, Taipei Medical University-Shuang Ho Hospital, Taiwan, 5Department of Medicine, University of Louisville, USA, 6Robley Rex Louisville VA Medical Center, USA Disclosures: Anthony Janckila, None

OSTEOCLASTS: CELL ADHESION SU0272

Small GTPases Rab14 and Rab4B are Required for Osteoclast Polarisation and Bone Resorption Cecile Itzstein*, Denise Tosh, Miep Helfrich, Fraser Coxon, Michael Rogers. University of Aberdeen, United Kingdom Disclosures: Cecile Itzstein, None

SU0273

The Redundancy Between PTP Epsilon and PTP Alpha in Osteoclasts Ari Elson, Eynat Finkelshtein*. Weizmann Institute of Science, Israel Disclosures: Eynat Finkelshtein, None

SU0274

Visualisation of the Apical Surface of Activated Osteoclasts Kinga Szewczyk*1, Karen Fuller 2, Raymond Moss1, Timothy Chambers3. 1St George’s University of London, United Kingdom, 2St. George’s University of London, United Kingdom, 3St. George’s Hospital Medical School, United Kingdom Disclosures: Kinga Szewczyk, None

OSTEOCLASTS: CYTOKINES AND GROWTH FACTORS SU0275

Activation of the Prostaglandin D2 CRTH2 Receptor Induces Apoptosis of Human Osteoclasts by the Intrinsic Apoptosis Pathway ´ DE SHERBROOKE, Canada, Li Yue1, Artur De Brum-Fernandes*2. 1UNIVERSITE 2 Universite De Sherbrooke, Canada Disclosures: Artur De Brum-Fernandes, None

SU0276

IL-23 Stimulates Human Osteoclast Formation and Bone Resorption In Vitro and IL-23 Neutralization Inhibits Bone Loss In Vivo Iannis Adamopoulos* 1, Cheng-chi Chao2, Eddie Bowman2. 1University of California, USA, 2Merck & Co., Inc., USA Disclosures: Iannis Adamopoulos, Merck, 3

SU0277

Interleukin-10 Regulates Bone Metabolism by Suppressing Osteoclastogenesis In Vivo Gunwoo Kim1, Seungwoo Han*2, Younkwan Jung3, Eunjoo Lee3. 1Department of internal medicine, Daegu Fatima hospital, South Korea, 2Daegu Fatima Hospital, South Korea, 3 Laboratory for arthritis & bone biology, Fatima research institute, South Korea Disclosures: Seungwoo Han, None

170

SU0278

Interplay Between Osteoclasts, Inflammatory Cells and Cytokines in the Pathogenesis of Periapical Bone Resorption Lea da Silva1, Sandra Fukada2, Andiara De Rossi*3, Marcos Rossi4. 1Faculty of Dentistry of Ribeira˜o Preto, University of Sa˜o Paulo, Brazil, 2Faculty of Pharmaceutic Sciences of Ribeira˜o Preto, University of Sa˜o Paulo, Brazil, 3Faculty of Dentistry of Ribeira˜o Preto, University of Sa˜o Paulo, Bra, 4Faculty of Medicine of Ribeira˜o Preto, University of Sa˜o Paulo, Brazil Disclosures: Andiara De Rossi, None

SU0279

STAT3 Is a Novel Target for Treating Bone Resorption in Rheumatoid Arthritis. Yoshiaki Toyama, Akihiko Yoshimura, Tomoaki Mori*, Takeshi Miyamoto. Keio University School of Medicine, Japan Disclosures: Tomoaki Mori, None

OSTEOCLASTS: DIFFERENTIATION SU0280

Choline Kinase Beta is an Important Regulator of Bone Homeostasis Jasreen Kular*1, Jennifer Tickner1, Nathan Pavlos2, Baysie Lim1, Tamara Abel1, Ming Hao Zheng1, Jiake Xu2. 1University of Western Australia, Australia, 2The University of Western Australia, Australia Disclosures: Jasreen Kular, None

SU0281

Double Stranded RNA Inhibits Osteoclast Differentiation via Interferon-beta/STAT1 Pathway and Increases Bone Mass in Osteoporosis Model Mice Arei Miyamoto* 1, Masamichi Takami2, Yoichi Miyamoto3, Atsushi Yamada4, Mijung Yim5, Tomohiko Tamura6, Ryutaro Kamijo3. 1School of Dentistry, Showa University, Japan, 2Department of Biochemistry, School of Dentistry, Showa University, Japan, 3 Showa University School of Dentistry, Japan, 4Showa University School of Dentistry, Jpn, 5 College of Pharmacy, Sookmyung Women’s University, South Korea, 6Department of Immunology, Graduate School of Medicine & Faculty of Medicine, Yokohama City University, Japan Disclosures: Arei Miyamoto, None

SU0282

Human Osteoclastogenesis and Aging: Roles of PPARc and c-fos Regina O’Sullivan*, Ping-Lin Chung, Shuanhu Zhou, Meryl Leboff, Julie Glowacki. Brigham & Women’s Hospital, USA Disclosures: Regina O’Sullivan, None

Hyperfunctions of Osteoclasts in a Rheumatoid Arthritis Model Kazuma Matsumoto*1, Naozumi Ishimaru 1, Takashi Izawa2, Masahiro Hiasa1, Yoshio Hayashi1, Eiji Tanaka1. 1University of Tokushima Graduate School, Japan, 2Washington University in St. Louis, USA Disclosures: Kazuma Matsumoto, None

SU0284

Involvement and Regulatory Role of Membrane Nanotubes in Fusion of Osteoclast Precursors: A Possible Migration and Penetration of DC-STAMP Protein into Osteoclast Precursors through Inter-Cellular Bridges Akira Takahashi*1, Akiko Kukita2, Yin-ji Li 3, Hisayuki Nomiyama 4, Yasunori Ayukawa5, Kiyoshi Koyano3, Toshio Kukita6. 1Kyuhsu University, Japan, 2Saga Medical School, Japan, 3Kyushu University, Japan, 4Kumamoto University, Japan, 5Kysuhu University, Japan, 6Kyushu University, Faculty of Dental Science, Japan Disclosures: Akira Takahashi, None

SU0285

Mapping the Transcription Factor Regulatory Network Involved in Osteoclast Differentiation Heather Carey*1, Fei Gu1, Lyudmyla Sharma1, Anand Merchant2, Raksha Adhikari1, Victor Jin 1, Sudarshana Sharma1, Michael Ostrowski 2. 1The Ohio State University, USA, 2 Ohio State University, USA Disclosures: Heather Carey, None

SU0286

Mechanisms for Radiation-Induced Bone Loss: Low Dose, Gamma Radiation Effects on Osteoclastogenesis and Osteoblastogenesis Akhilesh Kumar*1, Joshua Alwood1, Luan Tran1, Arundhati Balid1, Charles Limoli2, Ruth Globus1. 1NASA Ames Research Center, USA, 2University of California, USA Disclosures: Akhilesh Kumar, None

171

Sunday

SU0283

SU0287

Mesenchymal Stem Cells markedly suppressed Inflammatory Bone Destruction in Rats with Adjuvant-induced Arthritis Toshio Takano*1, Yin-ji Li 1, Akiko Kukita2, Takayoshi Yamaza 1, Yasunori Ayukawa 1, Kiyoshi Koyano1, Toshio Kukita3. 1Kyushu University, Japan, 2Saga Medical School, Japan, 3Kyushu University, Faculty of Dental Science, Japan Disclosures: Toshio Takano, None

SU0288

MicroRNA Targets of RANKL During Osteoclast Differentiation; miR-146a as a Lineage Determining Factor for Osteoclasts in Myeloid Precursors Sudarshana Sharma*1, Sankha Ghosh2, Haritha Mathsyaraja2, Jamie Wolf2, Michael Ostrowski2. 1The Ohio State University, USA, 2Ohio State University, USA Disclosures: Sudarshana Sharma, None

SU0289

Negative Regulation of Osteoclastogenesis by beta2 Integrin-Bcl6 Axis Kyung-Hyun Park-Min*1, Eun-Young Lee 2, Nick Brownell1, Neal Moskowitch3, LIONEL IVASHKIV1. 1Hospital for Special Surgery, USA, 2Seoul National University, South Korea, 3Arthritis group, USA Disclosures: Kyung-Hyun Park-Min, None

SU0290

Orai1-Mediated Calcium Entry Plays a Critical Role in Osteoclast Differentiation and Function by Regulating Activation of the Transcription Factor NFATc1 Sung-Yong Hwang*, James Putney. National Institute of Environmental Health Sciences, USA Disclosures: Sung-Yong Hwang, None

SU0291

Osteoclastogenesis is Highly Dependent on Exogenous Cholesterol, and Deficiency of Low Density Lipoprotein Receptor in Mice Causes Impaired Osteoclastic Cell Fusion and Increase in Bone Mass Mari Okayasu*, Chiyomi Hayashida, Mai Nakayachi, Takuya Sato, Junta Ito, Naoto Suda, Yoshiyuki Hakeda. Meikai University School of Dentistry, Japan Disclosures: Mari Okayasu, None

SU0292

Osteoclastogenic Potential of Mandible vs Long Bone Marrow Thawinee Chaichanasakul*1, Olga Bezouglaia 2, Tara Aghaloo3, Sotirios Tetradis1. 1 UCLA, USA, 2UCLA School of Dentistry, USA, 3University of California, Los Angeles, USA Disclosures: Thawinee Chaichanasakul, None

SU0293

Pam3CSK4, a TLR2 Agonist, Induces In Vitro Osteoclastogenesis RANKL-independently and Resorbs Alveolar Bone in Rats Akiko Yano*1, Keiko Suzuki2, Tomio Morohashi 2, Takafumi Arimoto2, Akiko Karakawa 1, Takeshi Igarashi2, Hisashi Shinoda3, Matsuo Yamamoto1, Shoji Yamada2. 1 Showa University School of Dentistry, Japan, 2Showa University, Japan, 3Tohoku University Graduate School of Dentistry, Japan Disclosures: Akiko Yano, None

SU0294

Role of the Fatty Acid Receptor GPR40 in Bone Remodeling Fabien Wauquier*1, claire philippe2, laurent leotoing2, sylvie mercier2, Jerome Guicheux3, Veronique Coxam4, Yohann Wittrant5. 1INRA, UMR 1019, UNH, CRNH Auvergne, F63009 Clermont-Ferrand, France, France, 2INRA, France, 3Inserm ADR Grand Ouest, France, 4INRA Theix, France, 5Institut National de la Recherche Agronomique, France Disclosures: Fabien Wauquier, AMGEN, 99

SU0295

TNFa Induced HLA-B27 Upregulation in Osteoclast Precursors Affects Osteoclast Development in a Rat Model of Spondyloarthritis Gerlinde Layh-Schmitt*1, Eva Yang2, Robert Colbert2. 1National Institutes of Health, USA, 2National Institutes of Health, NIAMS, USA Disclosures: Gerlinde Layh-Schmitt, None

172

OSTEOCLASTS: INHIBITION OF RESORPTION SU0296

(-)-Epigallocathechin-3-gallate (EGCG), an AMPK Activator, Inhibits Ovariectomy-Induced Bone Loss by Suppressing Bone Resorption Sook-Young Park1, Shin-Yoon Kim 2, Hong-Hee Kim3, Sun Wook Cho4, Hyung Jin Choi4, Seung Hun Lee*5, Ghi Su Kim6, Young-Sun Lee1, Chan Soo Shin4, Beom-Jun Kim7, SunYoung Lee1, Jung-Min Koh 7. 1Asan Institute for Life Sciences, South Korea, 2Kyungpook National University Hospital, South Korea, 3Seoul National University, South Korea, 4 Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 5Asan Medical Center, University of Ulsan College of Medicine, South Korea, 6 Division of Endocrinology & Metabolism, Asan Medical Center, University of Ulsan College of Medicine, South Korea, 7Asan Medical Center, South Korea Disclosures: Seung Hun Lee, None

SU0297

Anti-apoptotic Bcl-2 Family Member Mcl-1 Positively Regulates Cell Viability and Negatively Regulates Bone-resorbing Activity of Osteoclasts Hironari Masuda* 1, Jun Hirose2, Yasunori Omata3, Hisataka Yasuda4, Kozo Nakamura3, Sakae Tanaka3. 1The University of Tokyo, Jpn, 2The University of Tokyo, Japan, 3The University of Tokyo, Japan, 4Oriental Yeast Company, Limited, Japan Disclosures: Hironari Masuda, None

SU0298

Estrogen does not Promote Apoptosis of Avian Osteoclasts in Medullary Bone of EstrogenTreated Male Japanese Quails. Shinji Hiyama* 1, Misa Takahashi2, Aya Oda2, Takashi Uchida3. 1Hiroshima University Graduate School of Biomedical Sciences, Japan, 2Hiroshima University, Faculty of Dentistry, Japan, 3Hiroshima University, Graduate School of Biomedical Sciences, Japan Disclosures: Shinji Hiyama, None

SU0299

High Knockdown of TCIRG1 Protein Expression Is Required for Resorption Deficiency in CD34+ Derived Human Osteoclasts Christian Thudium*1, Ilana Moscatelli2, Johan Richter 2, Kim Henriksen3. 1Nordic Bioscience, Denmark, 2Lund University, Sweden, 3Nordic Bioscience A/S, Denmark Disclosures: Christian Thudium, None

SU0300

Disclosures: Melissa Cantley, None SU0301

Snx10: a Sortin Nexin Required for Osteoclast Differentiation and Function Cui Hua Zhu*1, Leslie Morse2, Ricardo Battaglino 1. 1The Forsyth Institute, USA, 2 Department of Physical Medicine & Rehabilitation, Harvard Medical School & Spaulding Rehabilitation Hospital, USA Disclosures: Cui Hua Zhu, None

SU0302

Syk Family Member ZAP70 Inhibits Syk-Mediated Osteoclast Function Wei Zou*1, Tingting Zhu2, Steven Teitelbaum 1. 1Washington University in St. Louis School of Medicine, USA, 2Washington University in St. Louis-School of Medicine, USA Disclosures: Wei Zou, None

SU0303

Transcription Factor E47 Regulates Homeostatic Bone Remodeling Through Upregulation of Inhibitor CD38 in Osteoclast Precursors Courtney Long*1, Xiao-Hong Sun2, Mary Beth Humphrey3. 1The University of Oklahoma Health Sciences Center, USA, 2Oklahoma Medical Research Foundation, USA, 3University of Oklahoma Health Sciences Center, USA Disclosures: Courtney Long, None

OSTEOCLASTS: ISOLATION AND LINEAGE SU0304

A Novel Identification Schema For Osteoclast Progenitors In Mice And In Humans Monique Bethel*1, Brahmananda Chitteti1, Yinghua Cheng1, Angela Bruzzaniti 2, Edward Srour1, Melissa Kacena1. 1Indiana University School of Medicine, USA, 2Indiana University School of Dentistry, USA Disclosures: Monique Bethel, None

173

Sunday

Histone Deacetylase (HDAC) Expression and HDAC Inhibition in Different Pathogenic Bone Loss Diseases. Melissa Cantley*1, David Fairlie2, Peter Mark Bartold1, Victor Marino2, David Haynes1. 1 University of Adelaide, Australia, 2University of Queensland, Australia

OSTEOCLASTS: SIGNAL TRANSDUCTION SU0305

A Unique Cytoplasmic Domain in RANK Induces Long-term Signaling Required for Osteoclast Differentiation Yuu Taguchi*, Jin Gohda, Jun-ichiro Inoue. The Institute of Medical Science, The University of Tokyo, Japan Disclosures: Yuu Taguchi, None

SU0306

Lysosomal Degradation of TRAF3 Is Important for RANKL/NF-kB -mediated Osteoclastogenesis Yan Xiu*1, Zhenqiang Yao2, Yoshikazu Morita2, Lianping Xing2, Brendan Boyce1. 1 University of Rochester Medical Center, USA, 2University of Rochester, USA Disclosures: Yan Xiu, None

SU0307

Protein Kinase D Regulates Osteoclast Differentiation Eric Jensen*, Lan Pham, Raj Gopalakrishnan, Kim Mansky. University of Minnesota, USA Disclosures: Eric Jensen, None

OSTEOCYTES: REGULATION OF BONE FORMATION SU0308

3D Visualization of Osteocyte Lacunae in the entire long bone Yoshihiro Takeda*1, Yasunari Takada2, Kazuhiko Omote1, Koichi Matsuo2. 1Rigaku Corporation, Japan, 2School of Medicine, Keio University, Japan Disclosures: Yoshihiro Takeda, None

SU0309

An In Vitro Model for Osteocyte Differentiation Ken Watanabe* 1, Hiroyuki Aburatani2, Kyoji Ikeda1. 1National Center for Geriatrics & Gerontology, Japan, 2RCAST, The University of Tokyo, Japan Disclosures: Ken Watanabe, None

SU0310

Connexin 43 Hemichannels Protect Osteocytes against Oxidative Stress Induced Cell Death Rekha Kar*1, Manuel Riquelme2, Sherry Werner2, Jean Jiang 3. 1The University of Texas Health Science Center, USA, 2University of Texas Health Science Center, USA, 3University of Texas Health Science Center at San Antonio, USA Disclosures: Rekha Kar, None

SU0311

Cox-2 Inhibition Suppresses the Response to Short Term Tibial Compression in Mice Bryan Hackfort*1, Gwendolin Alvarez1, Mohammed Akhter2, Diane Cullen1. 1Creighton University, USA, 2Creighton University Osteoporosis Research Center, USA Disclosures: Bryan Hackfort, None

SU0312

Load responsive Genes and Inflammation-Associated Genes are elevated in Dmp1 null Osteocytes while Genes associated with Bone Formation are Suppressed Stephen Harris*1, Marie Harris1, Yong Cui 2, Lynda Bonewald3, Jian Feng4, Jelica GluhakHeinrich1. 1University of Texas Health Science Center at San Antonio, USA, 2UTHSCSA, USA, 3University of Missouri - Kansas City, USA, 4Texas A&M Health Science Center, USA Disclosures: Stephen Harris, None

SU0313

MT1-MMP Affects the Mechanosensitivity of Osteocytes Rishikesh N. Kulkarni1, Astrid D. Bakker1, Elisabeth V. Gruber2, Thomas D. Chae3, Joris B. B. Veldkamp1, Vincent Everts1, Jenneke Klein-Nulend*1. 1ACTA-University of Amsterdam & VU University Amsterdam, Dept Oral Cell Biology, Research Institute MOVE, Netherlands, 2Medical University of Vienna, Bernhard Gottlieb School of Dentistry, Bone Research Group, Austria, 3Columbia University College of Dental Medicine, USA Disclosures: Jenneke Klein-Nulend, University of Amsterdam, 2

SU0314

Osteogenic Transcriptome Regulation in MLO-Y4 Osteocytes Exposed to Fluid Flow Peter Govey*1, Norman Karin2, Henry Donahue3. 1Penn State College of Medicine, USA, 2 Pacific Northwest National Laboratory, USA, 3The Pennsylvania State University College of Medicine, USA Disclosures: Peter Govey, None

174

SU0315

Quasi-3D Dynamics of Actin and Microtubule Networks in Individual MLO-Y4 Osteocytes under Steady and Oscillatory Flow Andrew Baik* 1, Jun Qiu2, Elizabeth Hillman1, Cheng Dong3, X Guo1. 1Columbia University, USA, 2Tsinghua University, China, 3Penn State University, USA Disclosures: Andrew Baik, None

SU0316

Radiation-Induced Bone Loss: Role of the Osteocyte Jeroen Buijs* 1, Laura Tedeschi2, Marc Mendonca1, Teresita Bellido2, Ted Bateman3, Khalid Mohammad1, Theresa Guise1. 1INDIANA UNIVERSITY, USA, 2Indiana University School of Medicine, USA, 3Univesity of North Carolina, USA Disclosures: Jeroen Buijs, None

OSTEOCYTES: REGULATION OF BONE MINERALIZATION SU0317

Dose-dependent Effects of Glucocorticoid on Anti-Oxidation, Autophagy and Apoptosis Junjing Jia*1, Wei Yao1, Min Guan2, Weiwei Dai3, Jean Jiang 4, Lynda Bonewald5, Nancy Lane1. 1University of California, Davis Medical Center, USA, 2University of California, at Davis Medical Center, USA, 3Department of Medicine, University of California at Davis Medical Center Sacramento, CA, USA, 4University of Texas Health Science Center at San Antonio, USA, 5University of Missouri - Kansas City, USA Disclosures: Junjing Jia, None

SU0318

Mediators of Osteocyte Apoptosis in Chronic Kidney Disease Renata Pereira*1, Thomas Lisse2, Harald Jueppner3, Isidro Salusky4, Katherine Wesseling 5. 1UCLA, USA, 2UCLA/Orthopaedic Hospital Research Center, USA, 3 Harvard Medical School & Mass. General Hospital, USA, 4University of California, Los Angeles School of Medicine, USA, 5UCLA Medical Center, USA Disclosures: Renata Pereira, None

OSTEOCYTES: REGULATION OF MINERAL ION HOMEOSTASIS SU0319

Disclosures: Yoshihito Ishihara, None SU0320

Effects of Ovariectomy and PTH(1-34) on Osteocyte Lacunar Properties in Adult Rats Donald Kimmel*1, Tiffany Fong2, Mohammed Akhter3, Thomas Wronski4. 1Kimmel Consulting Services, USA, 2Xradia, Inc., USA, 3Creighton University Osteoporosis Research Center, USA, 4University of Florida, USA Disclosures: Donald Kimmel, Xradia, Inc., 5

OSTEOPOROSIS ASSESSMENT: BIOCHEMICAL MARKERS SU0321

A Novel ELISA Assay for Detecting the Active Form of Cathepsin K in Human Serum Yujia Ding1, Qinlong Zheng1, Morten Karsdal2, Kim Henriksen*2. 1Nordic Bioscience Beijing, China, 2Nordic Bioscience A/S, Denmark Disclosures: Kim Henriksen, None

SU0322

Circulating OPG In Femoral Osteoporotic Fracture-Healing Costantino Corradini*1, Jacopo Bernieri2, Vittorio Macchi2, Emiliano Malagoli2, Cesare Verdoia 2. 1State University of Milan, Italy, 2University of Milan, Italy Disclosures: Costantino Corradini, None

SU0323

Ketonuria’s Metabolic Benefits on Bone Metabolism in Korean Women SANG HYEON JE*1, Nam-Seok Joo 2, KYU-NAM KIM3, Kwang-Min Kim2, Duck Joo Lee4. 1Ajou University Hospital, Department of Family Medicine, South Korea, 2Ajou University Hospital, South Korea, 3Ajou University, South Korea, 4Ajou University School of Medicine, South Korea Disclosures: SANG HYEON JE, None

175

Sunday

Ex-vivo Imaging of the Autonomous Intracellular Ca2+ Oscillations of Osteoblasts and Osteocytes in Bone Yoshihito Ishihara*1, Yasuyo Sugawara 2, Hiroshi Kamioka3, Noriaki Kawanabe4, Hiroshi Kurosaka 5, Keiji Naruse6, Takashi Yamashiro5. 1Okayama University, Japan, 2Okayama University Graduate School of Medicine, Dentistry, & Pharmacentical Sc, Japan, 3 Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sc, Japan, 4Okayama University Hospital, Japan, 5Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sciences, Japan, 6Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Science, Japan

SU0324

Serum PINP Predicts Changes Caused by Intermittent PTH(1-34) Treatment in Mechanical Properties and Other Bone Parameters in Adult Ovariectomized Osteopenic Rats Jussi Halleen*1, ZhiQi Peng1, Katja Fagerlund1, Tiina Suutari1, Jukka Va¨a¨ra¨niemi1, Mari Suominen1, Jukka Rissanen 2, Harrie Boonen3, Trine Neerup 4, Hanne Bak4, Jukka Morko1. 1Pharmatest Services Ltd, Finland, 2Pharmatest Services,Limited, Finland, 3 University of Copenhagen, Denmark, 4Zealand Pharma A/S, Denmark Disclosures: Jussi Halleen, Pharmatest Services Ltd, 3; Pharmatest Services Ltd, 4; IDS Ltd, 5

SU0325

Usability of Serum Tartrate-resistant Acid Phosphatase Type 5b (TRACP-5b) in Rat Ovariectomy Model Wataru Kikuchi* 1, Yasuaki Namatame1, Yuri Matsuki1, Iwao Kiyokawa1, Fumio Nomura2, Kimimitsu Oda3, Toshihide Miura1. 1Nittobo Medical Co., Ltd., Japan, 2 Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Japan, 3Department of Oral Life Science, Graduate School of Medical & Dental Sciences, Niigata University, Japan Disclosures: Wataru Kikuchi, None

OSTEOPOROSIS ASSESSMENT: BONE MINERAL DENSITY SU0326

Central DXA Utilization in Medicare Beneficiaries in the Wake of Reimbursement Changes Jie Zhang*1, Elizabeth Delzell 1, Hong Zhao1, Andrew Laster2, Kenneth Saag1, Meredith Kilgore3, Michael Morrisey1, Nicole Wright1, Huifeng Yun1, Jeffrey Curtis 1. 1University of Alabama at Birmingham, USA, 2Arthritis & Osteoporosis Consultants of the Carolinas, USA, 3University of Alabama At Birmingham School of Public Health, USA Disclosures: Jie Zhang, Amgen, 2

SU0327

Comparison of the Effect of Surrounding Fat On Measurements of BMD By DXA And High Resolution Quantitative Computerized Tomography Edward Colt*1, Muhammad Akram2, Fahad Javed1, Elizabeth Shane3, Stephanie Boutroy4. 1Columbia University & St. Luke’s-Roosevelt Hospital, USA, 2St. Luke’sRoosevelt Hospital, USA, 3Columbia University College of Physicians & Surgeons, USA, 4 Columbia University Medical Center, New York, NY, USA, USA Disclosures: Edward Colt, None

SU0328

DXA and HR-pQCT Detect Minimal Bone Loss After Kidney Transplantation with Early Corticosteroid Withdrawal Lucas Nikkel*1, Chiyuan Zhang2, Sumit Mohan3, Bekir Tanriover3, David Cohen3, Lloyd Ratner3, Geoffrey Dube3, Stephanie Boutroy4, Xiaowei Liu3, Donald McMahon3, Elizabeth Shane3, Thomas Nickolas1. 1Columbia University Medical Center, USA, 2 Columbia University, USA, 3Columbia University College of Physicians & Surgeons, USA, 4Columbia University Medical Center, New York, NY, USA, USA Disclosures: Lucas Nikkel, None

SU0329

Influence of Vertebral Fracture Assessment on Osteoporosis Treatment Violaine Carcasse`s* 1, Jacques Fechtenbaum2, Christine Bonnet3, Pascale Vergne-Salle 3, Alexandra Poinas3, Philippe Bertin 3. 1Hospital center, France, 2Centre D’Evaluation, Des Maladies Osseuses, France, 3University hospital center, France Disclosures: Violaine Carcasse`s, None

SU0330

Measurement of Bone Mineral Density and Bone Mineral Content Under an Oxford HemiKnee Arthroplasty Device – Precision Study Allison Heard1, Gary Hooper2, Rachel March1, Rod Maxwell 2, Christopher Frampton3, Ian Penny2, Nigel Gilchrist*4, Patricia Maguire1. 1CGM Research Trust, Christchurch, New Zealand, 2Department of Orthopaedic Surgery, Christchurch Hospital, New Zealand, 3 Department of Medicine, Christchurch School of Medicine & Health Sciences, University of Otago, New Zealand, 4Department of Orthopaedic Medicine & Surgery, Christchurch Hospital, New Zealand Disclosures: Nigel Gilchrist, None

176

SU0331

The Prevalence of Vertebral fractures in Irish patient attending for Dual Emission X-ray Absorptiometry (DXA) using Lateral Vertebral Assessment (LVA) Bill Walsh1, David Crosby1, Kara Fitzgerald2, Georgina Steen1, Miriam Casey1, James Walsh3, Joseph Browne*1. 1Bone Health & Osteoporosis Unit, St James’s Hospital, Ireland, 2 Bone Health & Osteoporosis Unit, St James’s Hosptial, Ireland, 3Trinity College Dublin, The University of Dublin, Ireland Disclosures: Joseph Browne, None

SU0332

Utility of FRAX and Q-fracture in the evaluation of T2DM patients. Pedro Rozas-Moreno 1, Rebeca Reyes-Garcı´a2, Antonia Garcı´a-Martı´n*2, Ine´s LuqueFerna´ndez2, Miguel Aguirre3, Manuel Munoz-Torres 4. 1Endocrinology Division. Hospital General de Ciudad Real. Ciudad Real, Spain., Spain, 2Bone Metabolic Unit (RETICEF). Endocrinology Division. Hospital Universitario San Cecilio. Granada, Spain., Spain, 3 Endocrinology Division. Hospital General de Ciudad Real. Ciudad Real, Spain., Spain, 4 University Hospital, Spain Disclosures: Antonia Garcı´a-Martı´n, None

OSTEOPOROSIS ASSESSMENT: BONE STRUCTURE SU0333

Assessment of Microarchitectural Parameters in Transiliac Bone Biopsies of Females and Males with Fragility Fractures Angela Trubrich*1, Christian Muschitz2, Roland Kocijan3, Christina Bittighofer4, Thomas Pirker5, Thomas Gross 6, Philippe Zysset7, Heinrich Resch8. 1Austria, 2St. Vincent’s Hospital, Austria, 3St.Vincent Hospital Vienna, Austria, 4Krankenhaus Barmherzige Schwestern, Austria, 5The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 6Institute of Lightweight Design & Structural Biomechanics, Technical University Vienna, Austria, 7Vienna University of Technology, Austria, 8Medical University Vienna, Austria Disclosures: Angela Trubrich, None

SU0334

Conception and Validation of a Non-Threshold based Processing and Analysis of Bone Images Roger Zebaze*1, Ali Ghasem-Zadeh1, Sandra Iuliano-Burns1, Kylie King1, Aloys Mbala2, Ego Seeman1. 1Austin Health, University of Melbourne, Australia, 2Strax Corp, Australia Disclosures: Roger Zebaze, None

SU0335

Disclosures: Shigeharu Uchiyama, None SU0336

Ethnic Variability in Bone Geometry as Assessed by Hip Structure Analysis: Study of Women Across the Nation (SWAN) Michelle Danielson*1, Thomas Beck2, Yinjuan Lian1, Kristine Ruppert1, Gail Greendale 3, Arun Karlamangla3, Jane Cauley4. 1University of Pittsburgh, USA, 2Quantum Medical Metrics, LLC, USA, 3University of California, Los Angeles, USA, 4University of Pittsburgh Graduate School of Public Health, USA Disclosures: Michelle Danielson, None

SU0337

Evaluation of a Novel Approach for Automatic Delineation of Vertebral Contours in Radiographs Peter Mysling1, Kersten Peter2, Mads Nielsen2, Martin Lillholm*3. 1Synarc Imaging Technologies & University of Copenhagen, Denmark, 2University of Copenhagen, Denmark, 3Synarc Imaging Technologies, Denmark Disclosures: Martin Lillholm, None

177

Sunday

Effect of Age on Femoral Neck Bone Strength using Quantitative CT, DXA, and Biochemical Markers of Bone Metabolism of the Normal Postmenopausal Women Shigeharu Uchiyama*1, Shota Ikegami2, Mikio Kamimura 3, Yoshiyuki Sasaki4, Mitsutoshi Sugano5, Yoshikazu Ido6, Akiko Takata6, Kiichi Nonaka7, Toshihiko Imaeda8, Yukihiko Hata6, Hiroyuki Kato9. 1Shinshu University, School of Medicine, Japan, 2Department of Orthopaedic, Japan, 3Kamimura Clinic, Japan, 4Radiology Division, Shinshu University Hospital, Japan, 5Laboratory Medicine, Shinshu University Hospital, Japan, 6 Rehabilitation Center, Shinshu University Hospital, Japan, 7Elk Corporation, Japan, 8 Department of Food & Nutritional Environment, Kinjo Gakuin University, Japan, 9 Department of Orthopaedic Surgery, Shinshu University School of Medicine, Japan

OSTEOPOROSIS ASSESSMENT: ULTRASOUND SU0338

Effect of Whole-Body Vibration on Calcaneal Quantitative Ultrasound Parameters in Osteopenic Postmenopausal Women: A Randomized Controlled Trial Lubomira Slatkovska* 1, Shabbir Alibhai 1, Joseph Beyene2, Queenie Wong1, Angela Cheung1. 1University Health Network, Canada, 2McMaster University, Canada Disclosures: Lubomira Slatkovska, None

SU0339

Quantitative Ultrasound for Bone Loss at a Critical Fracture Site; the Distal Radius. Frederick Serra-Hsu* 1, Jiqi Cheng2, Yi-Xian Qin3. 1State University of New York, Stony Brook, USA, 2SUNY Stony Brook, USA, 3State University of New York at Stony Brook, USA Disclosures: Frederick Serra-Hsu, None

SU0340

Ultrasonic Assessment of the Ultra-Distal Radius Jonathan Kaufman*1, Gangming Luo1, Xiaowei Liu2, Fernando Rosete2, Polly Chen 3, Mafo Kamanda-Kosseh2, Donald McMahon 2, Emily Stein2, Elizabeth Shane2, Robert Siffert4. 1CyberLogic, Inc., USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA, 4The Mount Sinai School of Medicine, USA Disclosures: Jonathan Kaufman, CyberLogic, Inc., 4; CyberLogic, Inc., 3

OSTEOPOROSIS EPIDEMIOLOGY: BONE MINERAL DENSITY SU0341

Bone Mineral Density Is Cross Sectionally Associated with Cartilage Volume in Healthy, Asymptomatic Adult Females: Geelong Osteoporosis Study Sharon Brennan1, Julie Pasco2, Flavia Cicuttini3, Margaret Henry4, Mark Kotowicz5, Geoff Nicholson6, Anita Wluka*7. 11.Department of Epidemiology & Preventive Medicine, Monash University 2. Northwest Academic Centre, Department of Medicine, The University of Melbourne, Australia, 2Deakin University, Australia, 3Department of Epidemiology & Preventive Medicine, Monash University, Australia, 4School of Medicine, Deakin University, Australia, 5Barwon Health, Australia, 6Rural Clinical School Research Centre I School of Medicine I The University of Queensland, Australia, 7Monash University & Alfred Hospital, Australia Disclosures: Anita Wluka, None

SU0342

Bone Mineral Density Screening and Osteoporosis Rates in Veterans Robert Adler 1, Joanne LaFleur*2, Jonathan Nebeker3, Candace Hayden3, Scott DuVall3, Thomas Ginter 3. 1McGuire VA Medical Center, USA, 2University of Utah, USA, 3VA Salt Lake City Healthcare System, USA Disclosures: Joanne LaFleur, None

SU0343

Epidemiologic Study on Osteoporosis in Polish Women: RAC-OST-POL Wojciech Pluskiewicz* 1, Bogna Drozdzowska1, Aleksandra Czekajlo2, Wladyslaw Grzeszczak 1, Piotr Adamczyk 1. 1Medical University of Silesia, Katowice, Poland, 2 Nefrolux, Siemanowice, Poland, Poland Disclosures: Wojciech Pluskiewicz, None

SU0344

How Frequent Is Premenopausal Osteoporosis In Clinical Practice? Alicia Bagur*, Silvina Mastaglia, Diana Gonzalez, Candela Fernandez, Beatriz Oliveri, Carlos Mautalen. Centro de Osteopatı´as Me´dicas, Buenos Aires, Argentina Disclosures: Alicia Bagur, None

SU0345

Occurrence of Falls in Elderly People in Brazil, There Is Something that Health Professionals Can do to Avoid? Thais Braga1, Roberto Queiroz1, Fabiana Fonseca*2, Bianca Segantin1, Manuela Santos1, Ursula Karsch1, Ana Elisa Segantin1. 1PUC - SP, Brazil, 2PUC Sp, Brazil Disclosures: Fabiana Fonseca, None

178

SU0346

Sclerostin is Associated with Age, BMI and Bone Mineral Content, but not Gender or Physical Activity in Healthy Adults Karin Amrein*1, Astrid Fahrleitner-Pammer2, Steven Amrein3, Camilla Drexler4, Hans Dimai2, Thomas R. Pieber5, Andreas Tomaschitz5, Harald Dobnig6. 1Medical University of Graz, Austria, 2Medical University Graz, Austria, 3Medical University of Graz, Austria, Department of Anaesthesiology & Intensive Care Medicine, Austria, 4Medical University of Graz, Austria, University Clinic of Blood Group Serology & Transfusion Medicine, Austria, 5Medical University of Graz, Austria, Division of Endocrinology & Metabolism, Department of Internal Medicine, Austria, 6Diagnostikinstitut Dr.B.Fueger, Institute for Endocrine & Bone Diseases, Aut Disclosures: Karin Amrein, None

SU0347

The Relationship Between Inflammatory Bowel Disease and Bone Mineral Density. Results of a Population-Based Study Laura Targownik* 1, Zoann Nugent2, Charles Bernstein2, William Leslie2. 1University of Manitobe, Canada, 2University of Manitoba, Canada Disclosures: Laura Targownik, None

SU0348

What Is The Value of Laboratory Testing to Identify Possible Secondary Contributors to Osteoporosis in Older Men? Howard Fink*1, Stephanie Litwack-Harrison 2, Kristine Ensrud3, Eric Orwoll4, Douglas Bauer5. 1GRECC, Minneapolis VA Medical Center, USA, 2San Francisco Coordinating Center, California Pacific Medical Center, USA, 3Minneapolis VA Medical Center / University of Minnesota, USA, 4Oregon Health & Science University, USA, 5University of California, San Francisco, USA Disclosures: Howard Fink, None

OSTEOPOROSIS EPIDEMIOLOGY: DIET AND ENVIRONMENTAL FACTORS SU0349

Disclosures: Carlos Gomez, None SU0350

Calcium and Vitamin D intakes in Canadian Youth Ages 16-24 years: the Canadian Multicentre Osteoporosis Study (CaMos) Wei Zhou*1, Lisa Langsetmo2, Claudie Berger3, Suzette Poliquin3, David Goltzman1, Stephanie Kaiser 4, Jerilynn Prior 5, Robert Josse 6, Tanveer Towheed 7, Tassos Anastassiades7, K. Shawn Davison8, Christopher Kovacs9, Manny Papadimitropoulos10, Nanncy Kreiger11. 1McGill University Health Centre, Canada, 2Canandian Multicenter Osteoporosis Study, Canada, 3McGill University, Canada, 4Dalhousie University, Canada, 5 University of British Columbia, Canada, 6St. Michael’s Hospital, University of Toronto, Canada, 7Queen’s University, Canada, 8Laval University, Canada, 9Memorial University of Newfoundland, Canada, 10Eli Lilly Canada Inc., Canada, 11University of Toronto, Canada Disclosures: Wei Zhou, None

SU0351

Dairy Calcium Intake Accompanied with Higher Intake of Vitamin D Could Efficiently Decrease Body Fat Mass and Increase Lean Mass without Decreasing BMD During Moderate Weight Loss in Normal Weight Young Japanese Women Takako Hirota*1, Izumi Kawasaki 2, Kenji Hirota3. 1Kyoto Koka Women’s University, Japan, 2Tsuji Academy of Nutrition, Japan, 3Hanwa Sumiyoshi General Hospital, Japan Disclosures: Takako Hirota, None

SU0352

Red Blood Cell n-3 and n-6 Fatty Acid Concentrations as Predictors of Inflammatory Markers in the Women’s Health Initiative Steven Ing*1, Tonya Orchard1, Andrea Lacroix2, Charles Kooperberg2, Aaron Aragaki 2, Martha Belury1, Bo Lu 1, Rebecca Jackson1. 1The Ohio State University, USA, 2Fred Hutchinson Cancer Research Center, USA Disclosures: Steven Ing, None

179

Sunday

Bone Mineral Density was Similar in Spanish Medieval Women and Higher in Medieval Men Compared to Actual Spanish Population Belen Lopez1, Carlos Gomez*2, Pablo Manrique1, Ana Gomez 1, Serafin Costilla3, Jorge Cannata Andia 4. 1Physical Anthropology, Department of Biology of Organisms & Systems, University of Oviedo, Spain, 2Hospital Universitario Central de Asturias, Spain, 3 Department of Radiology. Hospital Universitario Central de Asturias University of Oviedo., Spain, 4Hospital Universitario Central de Asturias, Spain

SU0353

Reduced T and Z Scores at the Femoral Neck and Lumbar Spine Are Associated With Increased Dietary Protein Intakes In UK Dwelling South Asian and Caucasian Postmenopausal Women Andrea Darling*, Kathryn Hart, Susan Lanham-New. University of Surrey, United Kingdom Disclosures: Andrea Darling, None

OSTEOPOROSIS EPIDEMIOLOGY: FRACTURE OUTCOME SU0354

Dietary Vitamin D Intake and the Risk of Fracture and Osteoporosis Greta Snellman*1, Eva Warensjo¨-Lemming2, Liisa Byberg2, Karl Michaelsson 2. 1 Department of surgical sciences, Uppsala University, Sweden, 2Uppsala Clinical Research Center, Sweden Disclosures: Greta Snellman, None

SU0355

Final Results from a Population-Based Post-Fracture Intervention Based Upon Administrative Health Data: A Randomized Controlled Trial. William Leslie*1, Lisa Labine2, Darlene Dreilich2, Penny Klassen2, Patricia Caetano2. 1 University of Manitoba, Canada, 2Manitoba Health, Canada Disclosures: William Leslie, None

SU0356

Hip Extensor Lean Cross-Sectional Area Is Associated with Incident Hip Fracture: The Age Gene/Environment Susceptibility Study-Reykjavik Thomas Lang*1, Sigurdur Sigurdsson 2, KRISTIN SIGGEIRSDOTTIR3, Gyda Karlsdottir 2, Gudny Eiriksdottir 2, Joyce Keyak4, Vilmundur Gudnason3, Tamara Harris5. 1 University of California, San Francisco, USA, 2Icelandic Heart Association, Iceland, 3 ICELANDIC HEART ASSOCIATION RESEARCH INSTITUTE, Iceland, 4University of California, USA, 5National Institute on Aging, USA Disclosures: Thomas Lang, Merck, 2; Glaxo-SmithKline, 2

SU0357

Hospitalizations for Hip Fractures and Femur Fractures below Trochanter Follow Similar Trends in Women Kurt Lippuner1, Lisa Strahm*1, Albrecht Popp1, Patrick Schwab2, Christoph Senn1, Romain Perrelet1. 1Osteoporosis Policlinic, University of Bern, Switzerland, 2Swiss Federal Statistical Office, Switzerland Disclosures: Lisa Strahm, None

SU0358

Hyperkyphosis and Incident Fractures Older Community Dwelling Women: The Study of Osteoporotic Fractures (SOF) Deborah Kado*1, Dana Miller-Martinez2, Lily Lui3, Kristine Ensrud4, Teresa Hillier5, Howard Fink 6, Marc Hochberg7, Peggy Cawthon3. 1University of California, Los Angeles, USA, 2David Geffen School of Medicine at UCLA, USA, 3California Pacific Medical Center Research Institute, USA, 4Minneapolis VA Medical Center / University of Minnesota, USA, 5Kaiser Center for Health Research, USA, 6GRECC, Minneapolis VA Medical Center, USA, 7University of Maryland School of Medicine, USA Disclosures: Deborah Kado, None

SU0359

Incidence of Fractures after Cardiac and Lung transplantation: A Single Center Experience Aileen Hariman*, Charles Alex, Biljana Pavlovic-Surjancev, Alain Heroux, Pauline Camacho. Loyola University of Chicago, USA Disclosures: Aileen Hariman, None

SU0360

Incidence of Osteoporotic Fracture in Patients with High Plasma Homocysteine Level Naohisa Miyakoshi1, Yuji Kasukawa1, Koji Nozaka*2. 1Akita University Graduate School of Medicine, Japan, 2Akita City Hospital, Japan Disclosures: Koji Nozaka, None

SU0361

Morbidity and Mortality After Hip Fracture with Using Jeju Cohort in South Korea : A Minimum 5 Year Follow-Up Jae-Suk Chang1, Yong-Chan Ha*2, Young-Kyun Lee 3, Hyun-Koo Yoon4, Deog-Yoon Kim5. 1Ulsan University, Asan Medical Center, South Korea, 2Chung-Ang University College of Medicine, South Korea, 3Seoul National University Bundang Hospital, South Korea, 4Cheil General Hospital & Women’s Healthcare Center, South Korea, 5Department of Nuclear Medicine, Kyung Hee University Medical Center, South Korea Disclosures: Yong-Chan Ha, None

180

SU0362

Quality of Life in Community-Dwelling Elderly Women: The Impact of Asymptomatic Vertebral Fractures JAQUELINE LOPES*1, Leandro Fung2, Carolina Cha2, Camille Figueiredo2, Liliam Takayama 2, Valeria Caparbo 2, Rosa Pereira3. 1Faculdade de Medicina da Universidade de Sa˜o Paulo, Sa˜o Paulo, Brazil, Brazil, 2Division of Rheumatology (Bone Mineral Metabolism Laboratory), Faculdade de Medicina da Universidade de Sa˜o Paulo, Brazil, 3 Faculdade de Medicina da Universidade de Sa˜o Paulo, Brazil Disclosures: JAQUELINE LOPES, None

SU0363

Review of Lower Extremity Fractures in Veterans with Spinal Cord Injury Helen Hoenig1, Titilola Akhigbe* 2, Amy Chin1, Stephen Burns3, Jelena Svircev4, Helen Hoenig1, Frances Weaver5, Kim Seunghyun2, Laura Carbone2. 1Department of Veterans Affairs, USA, 2University of Tennessee Health Science Center, USA, 3Puget Sound, USA, 4 VA Puget Sound, USA, 5Edward Hines Jr. VA Hospital, USA Disclosures: Titilola Akhigbe, None

SU0364

Review of Radiological Scoring Methods of Osteoporotic Vertebral Fractures for Clinical and Research Settings Felisia Ly*1, Ling Oei 2, Carola Zillikens1, Andre Uitterlinden 3, Gabriel Krestin1, Fernando Rivadeneira 4, Edwin Oei 1. 1Erasmus MC, Netherlands, 2Erasmus University Medical Center, The Netherlands, 3Rm Ee 575, Genetic Laboratory, The Netherlands, 4Erasmus University Medical Center, The Netherlands Disclosures: Felisia Ly, None

SU0365

Serum Vitamin D Level and Functional Outcomes in Patients with Fragility Fractures,Shifting the Paradigm Lohrasb Ahmadian*, Joseph Lane. Hospital for Special Surgery, USA Disclosures: Lohrasb Ahmadian, None

OSTEOPOROSIS EPIDEMIOLOGY: GENETIC STUDIES SU0366

Disclosures: Joo-Yeon Hwang, None

181

Sunday

A Novel MECOM Gene Predisposing to Osteoporotic Fracture Identified by a Combined Meta-analysis and Functional Effects Joo-Yeon Hwang*1, Seung Hun Lee 2, Min Jin Go3, Beom-Jun Kim4, Shiro Ikegawa5, Kou Ikuyo5, Unnur Styrkarsdottir 6, Soumya Raychaudhuri 7, Young Jin Kim3, Dong-Joon Kim3, Ji Hee Oh3, Heejo Koo 3, My-Jung Cha3, Min Hye Lee3, Ji Young Yun3, Hye-Sook Yoo3, Young-Ah Kang3, Ki Won Oh8, Moo Il Kang9, Ho Young Son9, Shin-Yoon Kim10, Ghi Su Kim11, Bok-Ghee Han3, Yoon Shin Cho3, Jong-Young Lee 3, Jung-Min Koh 4. 1 Korea National Institute of Health, Center for Genome Science, South Korea, 2Asan Medical Center, University of Ulsan College of Medicine, South Korea, 3Center for Genome Science, KNIH, South Korea, 4Asan Medical Center, South Korea, 5RIKEN, Japan, 6Decode Genetics, Iceland, 7Broad Institute, USA, 8Sungkyunkwan university, South Korea, 9CMC, South Korea, 10Kyungpook National University Hospital, South Korea, 11University of Ulsan, South Korea

SU0367

Assessment of Gene-by-sex Interaction Effect on Bone Mineral Density Ching-Ti Liu* 1, Yi-Hsiang Hsu 2, Karol Estrada3, Vangelis Evangelou4, Yanhua Zhou5, Laura Yerges-Armstrong6, Najaf Amin7, Nicole Glazer8, Ryan Minster9, Gudmar Thorleifsson10, Jane Cauley11, CM van Duijn12, Tamara Harris13, John Ioannidis 4, Yongmei Liu14, Braxton Mitchell15, Jeffery R O’Connell 16, John Robbins17, Elizabeth Streeten 16, Unnur Styrkarsdottir 18, Andre Uitterlinden 19, M Zillikens20, Fernando Rivadeneira 3, David Karasik21, L Adrienne Cupples1, Douglas Kiel21. 1Boston University School of Public Health, USA, 2Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 3Erasmus University Medical Center, The Netherlands, 4University of Ioannina School of Medicine, Greece, 5Boston University, USA, 6University of Maryland, USA, 7Erasmus University Medical Center, Netherlands, 8Boston University School of Medicine, USA, 9University of Pittsburgh, USA, 10deCODE Genetics, Reykjavı´k, Iceland, Ireland, 11University of Pittsburgh Graduate School of Public Health, USA, 12 Erasmus University Medical Center, Ireland, 13Intramural Research Program, National Institute on Aging, USA, 14Wake Forest University School of Medicine, USA, 15University of Maryland, Baltimore, USA, 16University of Maryland School of Medicine, USA, 17 University of California, Davis Medical Center, USA, 18deCODE Genetics, Reykjavı´k, Iceland, Iceland, 19Rm Ee 575, Genetic Laboratory, The Netherlands, 20Erasmus MC Rotterdam, The Netherlands, 21Hebrew SeniorLife, USA Disclosures: Ching-Ti Liu, None

SU0368

Genome-Wide Association Meta-Analysis of Cortical Volumetric BMD Identifies Three Known and One Novel Bone-Related Loci Claes Ohlsson*1, Lavinia Paternoster2, Terho Lehtima¨ki3, Mika Ka¨ho¨nen4, Olli Raitakari5, Marika Laaksonen6, Vera Mikkila¨6, Jorma Viikari7, Leo-Pekka Lyytika¨inen3, John P Kemp2, Adrian Sayers8, Maria Nethander9, Liesbeth Vandenput 10, Jon H Tobias11, Mattias Lorentzon 12, David M Evans2. 1Centre for Bone & Arthritis Research, Sweden, 2 MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol; School of Social & Community Medicine, University of Bristol, United Kingdom, 3 Department of Clinical Chemistry, University of Tampere & Tampere University Hospital, Finland, 4Department of Clinical Physiology, University of Tampere & Tampere University Hospital, Finland, 5Research Centre of Applied & Preventive Cardiovascular Medicine, University of Turku & the Department of Clinical Physiology, Turku University Hospital, Finland, 6Department of Food & Environmental Sciences, University of Helsinki, Finland, 7 Department of Medicine, University of Turku & Turku University Hospital, Finland, 8 University of Bristol, United Kingdom, 9Genomics Core Facility, University of Gothenburg, Sweden, 10University of Gothenburg, Sweden, 11School of Clinical Sciences, University of Bristol, United Kingdom, 12Center for Bone Research at the Sahlgrenska Academy, Sweden Disclosures: Claes Ohlsson, None

SU0369

Genome-wide Association Study of Hip Fracture Suggests Loci in Biological Pathways Associated with Bone Remodeling Rebecca Jackson*1, Andrea LaCroix2, Aaron Aragaki2, David Duggan3, Chris Carlson4, Brent Richards5, Zari Dastani5, Tim Spector6, John Eisman7, Tuan Nguyen7, Stuart Ralston8, Eugene McCloskey9, Emma Duncan10, Geoffrey Nicholson11, William Leslie12, David Goltzman13, Subha Krishnan3, Charles Kooperberg 2. 1The Ohio State University, USA, 2Fred Hutchinson Cancer Research Center, USA, 3Translational Genomics Research Institute, USA, 4University of Washington, USA, 5McGill University, Canada, 6King’s College London, United Kingdom, 7Garvan Institute of Medical Research, Australia, 8 University of Edinburgh, United Kingdom, 9University of Sheffield, United Kingdom, 10 Royal Brisbane & Women’s Hospital, Australia, 11The University of Queensland, Australia, 12University of Manitoba, Canada, 13McGill University Health Centre, Canada Disclosures: Rebecca Jackson, None

182

OSTEOPOROSIS EPIDEMIOLOGY: LIFESTYLE AND BONE (ALCOHOL, TOBACCO) SU0370

Increased Physical Activity Associated with Longitudinal Decrease in Weight, and Increase in Bone Mineral Density: The Canadian Multicentre Osteoporosis Study (CaMos) Lisa Langsetmo*1, Christine Hitchcock2, Elaine Kingwell 2, K. Shawn Davison3, Siri Forsmo4, Wei Zhou5, Claudie Berger6, Nancy Kreiger7, Jerilynn Prior2. 1Canandian Multicenter Osteoporosis Study, Canada, 2University of British Columbia, Canada, 3Laval University, Canada, 4Norwegian University of Science & Technology, Norway, 5McGill University Health Centre, Canada, 6McGill University, Canada, 7University of Toronto, Canada Disclosures: Lisa Langsetmo, None

OSTEOPOROSIS EPIDEMIOLOGY: MENOPAUSE AND GONADAL STEROIDS SU0371

Effect of Menopause on Bone Loss in HIV-infected Women Michael Yin*1, Chiyuan Zhang1, Polly Chen1, Ivelisse Colon 2, Donald McMahon3, David Ferris4, Emily Stein3, Phyllis Tien5, Elizabeth Shane3. 1Columbia University, USA, 2 Columbia University Medical Center, USA, 3Columbia University College of Physicians & Surgeons, USA, 4Bronx Lebanon Hospital Center, USA, 5University of California, San Francisco, USA Disclosures: Michael Yin, None

SU0372

Disclosures: Yi-Hsiang Hsu, None SU0373

Relative Contributions of Estradiol and Testosterone to the Determination of Bone Mineral Density in Vietnamese Men and Women Lan T Ho-Pham*1, Thai Q. Lai2, Nguyen Nguyen3, Tuan Nguyen3. 1Pham Ngoc Thach University of Medicine, Vietnam, 2People’s Hospital 115, Vietnam, 3Garvan Institute of Medical Research, Australia Disclosures: Lan T Ho-Pham, None

OSTEOPOROSIS EPIDEMIOLOGY: RISK FACTORS SU0374

4-year Follow-up of the Bone Fracture Risk with FRAX in Patients not Treated with Antifracture Medicines. Pomost study Jerzy Przedlacki*, Krystyna Ksie˛z˙opolska-Orłowska, Artur Grodzki, Andrzej S´wirski, Jan Musiał, Ewa Loth, Paweł Teter, Andrzej Łasiewicki. National Center of Osteoporosis, Poland Disclosures: Jerzy Przedlacki, None

SU0375

Depressive Symptoms on Balance Function and Osteoporosis: Result from CMC Study Ki-Hyun Baek1, Moo-Il Kang2, Hyeon-Woo Yim3, Sun-Hee Ko2, Seong-Su Lee4, Eunhee Jang*5, Ki-Won Oh6. 1St. Mary’s Hospital, South Korea, 2Seoul St. Mary’s Hospital, South Korea, 3Department of Preventive Medicine, The Catholic University of Korea, South Korea, 4Catholic medical college, South Korea, 5St.Mary’s Hospital, Republic of Korea, 6Kangbuk Samsung Hospital, Sungkyunkwan University, South Korea Disclosures: Eunhee Jang, None

183

Sunday

Pleiotropic Genetic Determinants of BMD and Ages at Menarche and Natural Menopause: Multivariate Genome-Wide Association Meta-Analyses Yi-Hsiang Hsu*1, Xing Chen2, Douglas Kiel2, Brent Richards3, Cathy Elks4, Jane Cauley5, Karol Estrada6, Michael Econs7, Kathryn Lunetta8, Ken Ong9, John Perry10, Fernando Rivadeneira 6, Lisette Stolk11, Tim Spector12, Andre Uitterlinden 13, M Zillikens14, Joanne Murabito15, David Karasik2. 1Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 2Hebrew SeniorLife, USA, 3McGill University, Canada, 4Inst of Metabolic Sci, Addenbrooke’s Hosp, United Kingdom, 5University of Pittsburgh Graduate School of Public Health, USA, 6Erasmus University Medical Center, The Netherlands, 7 Indiana University School of Medicine, USA, 8Boston Uni Sch Public Health, USA, 9 Paediatrics, University of Cambridge, United Kingdom, 10Inst Biomedical Clinical Science, Peninsula Med Sch, United Kingdom, 11Departments of Internal Medicine, Erasmus MC, Netherlands, 12King’s College London, United Kingdom, 13Rm Ee 575, Genetic Laboratory, The Netherlands, 14Erasmus MC Rotterdam, The Netherlands, 15 Boston Uni Sch Med, USA

SU0376

Genome-wide Copy Number Variation Analysis on the Risk of Osteoporotic Fractures in Caucasian Men and Women: The Framingham Osteoporosis study Kannabiran Nandakumar*1, Ching-Lung Cheung2, Huanyu Zhou3, Ching-Ti Liu 4, Serkalem Demissie5, David Karasik6, Adrienne Cupples5, Douglas Kiel6, Yi-Hsiang Hsu7. 1 Hebrew Senior Life Harvard Medical School, USA, 2The University of Hong Kong, Hong Kong, 3Hebrew Rehabilitation Center, USA, 4Boston University School of Public Health, USA, 5BUSPH, USA, 6Hebrew SeniorLife, USA, 7Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA Disclosures: Kannabiran Nandakumar, None

SU0377

Hypovitaminosis D in Postmenopausal Women with a Distal Radius Fracture Woo Young Chang, Hyun Sik Gong*, Cheol Ho Song. Seoul National University Bundang Hospital, South Korea Disclosures: Hyun Sik Gong, None

SU0378

Incidence of Multiple Falls and Risk Factors in a Longitudinal Population-Based Cohort Study in Japan: The ROAD Study Shigeyuki Muraki*1, Toru Akune1, Hiroyuki Oka1, Kozo Nakamura 2, Hiroshi Kawaguchi3, Noriko Yoshimura1. 122nd Century Medical & Research Center, University of Tokyo, Japan, 2The University of Tokyo, Japan, 3University of Tokyo, Faculty of Medicine, Japan Disclosures: Shigeyuki Muraki, None

SU0379

Lack of Evidence Defining Vitamin D Inadequacy as Less than 30 ng/ml of Serum 25(OH)D Sena Hwang*1, Han Seok Choi2, Kyoung Min Kim3, Kwang Joon Kim3, Yumie Rhee 1, Sung-Kil Lim1. 1Yonsei University College of Medicine, South Korea, 2Division of Endocrinology & Metabolism, Department of Internal MedicineDongguk University Ilsan Hospital, South Korea, 3Institute of Endocrine Research, & Brain Korea 21 Project for Medical Sciences, South Korea Disclosures: Sena Hwang, None

SU0380

Non-traumatic Fractures and the Treatment Care Gap in Individuals with Diabetes: the Canadian Multicentre Osteoporosis Study Lisa-Ann Fraser*1, Jonathan Adachi2, Alexandra Papaioannou3, Lehana Thabane3. 1 University of Western Ontario, McMaster University, Canada, 2St. Joseph’s Hospital, Canada, 3McMaster University, Canada Disclosures: Lisa-Ann Fraser, None

SU0381

Prediction of Fractures over 6 Years from FRAXH in Older Women: Recent Falls History as a Further Independent Risk Factor Judith Finigan*1, Claus-C Glueer2, Dieter Felsenberg3, David Reid4, Christian Roux5, Richard Eastell1. 1University of Sheffield, United Kingdom, 2Christian Albrechts Universitaet zu Kiel, Germany, 3Charite´ - Campus Benjamin Franklin, Germany, 4 University of Aberdeen, United Kingdom, 5Hospital Cochin, France Disclosures: Judith Finigan, None

SU0382

Risk Factors for Vertebral Fractures in Frail, Long Term Care Residents Mary Anne Ferchak, Megan Miller, Kimberly Zukowski, Carroll Lee*, Subashan Perera, David Nace, Gail Fiorito, Neil Resnick, Susan Greenspan. University of Pittsburgh, USA Disclosures: Carroll Lee, None

SU0383

Six Year Follow up in Patients with Previous Osteoporotic Fracture of Proximal Femur Vaclav Vyskocil*1, Tomas Pavelka2, Monika Honnerova 3. 1Center for Metabolic Bone Diseases, Czech Republic, 2Department of Orthopaedic Surgery, Czech Republic, 3 Department of Bone Disease, Czech Republic Disclosures: Vaclav Vyskocil, None

SU0384

Ten Year Probability of Fractures Estimation with the WHO Fracture Risk Assessment Algorithm in Subjects with Osteopenia Naive to Treatment in the Latin America Vertebral Osteoporosis Study (LAVOS) Population, Puerto Rico Site Rafael Gonza´lez*1, Leticia Herna´ndez1, Lillian Haddock-Suarez2. 1University of Puerto Rico, School of Medicine, Puerto Rico, 2University of Puerto Rico School of Medicine, Puerto Rico Disclosures: Rafael Gonza´lez, None

184

SU0385

The Association Between Newer Anticonvulsants and Bone Mineral Density Richard Lee*1, Kenneth Lyles2, Richard Sloane2, Cathleen Colon-Emeric2. 1Duke University, USA, 2Duke University Medical Center, USA Disclosures: Richard Lee, None

SU0386

The Importance of Morphometric Radiographic Vertebral Fracture Assessment for the Detection of Patients Who Need Pharmacological Treatment of Osteoporosis among Postmenopausal Diabetic Korean Women Yong Jun Choi*1, Seoung-Oh Yang2, Chan Soo Shin3, Yoon-Sok Chung1. 1Ajou University School of Medicine, South Korea, 2Asia Cancer Center, South Korea, 3 Department of Internal Medicine, Seoul National University College of Medicine, South Korea Disclosures: Yong Jun Choi, None

SU0387

Utilization of osteoporosis Medications in Women With and Without Diabetes Mellitus Nicole Wright*, Elizabeth Delzell, Paul Muntner, Jeffrey Curtis, April Carson, Monika Safford. University of Alabama at Birmingham, USA Disclosures: Nicole Wright, Amgen, 2

SU0388

Vertebral Morphometry and its Heterogeneity Predict Lumbar Vertebral Fracture in Postmenopausal Women. The OFELY Study Safaa Belghali1, Jean-Paul Roux*2, Elisabeth Sornay-Rendu2, Roland Chapurlat2. 1 INSERM, UMR1033, Universite´ de Lyon, France, 2INSERM, UMR 1033, Universite´ de Lyon, France Disclosures: Jean-Paul Roux, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE MINERAL DENSITY SU0389

Circulating Sclerostin Demonstrates a Circadian Rhythm in Young Healthy Men Shankar Narayan H Santosh*1, Frank Joseph2, Amanda Hamilton3, Brian Durham4, Anna Robinson 4, Jonathan Tang3, Jiten P Vora3, William D Fraser 5. 1The Royal Liverpool University Hospital, GBR, 2Countess of Chester Hospital NHS Trust, United Kingdom, 3 Royal Liverpool University Hospital, United Kingdom, 4University of Liverpool, United Kingdom, 5Department of Clinical Chemistry, University of Liverpool, United Kingdom Disclosures: Shankar Narayan H Santosh, None

SU0390

Disclosures: Janet Funk, None SU0391

Take Two to Tango: Estrogen Deficiency and Increased Iron in Postmenopausal Osteoporosis Qing Yang1, Jinlong Jian1, Florence Huang2, Xi Huang*3. 1New York University Medical Center, USA, 2Bergen County Academy, USA, 3New York University School of Medicine, USA Disclosures: Xi Huang, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE REMODELING SU0392

Central IL-1 Signaling Regulates Bone Mass Via Parasympathetic Skeletal Innervation Alon Bajayo*1, Arik Bar2, Adam Denes3, Marilyn Bachar2, Vardit Kram2, Malka AttarNamdar2, Alberta Zallone4, Raz Yirmiya2, Itai Bab5. 1Hebrew University, Faculty of Dentistry, Israel, 2Hebrew University of Jerusalem, Israel, 3University of Manchester, United Kingdom, 4University of Bari Medical School, Italy, 5The Hebrew University, Israel Disclosures: Alon Bajayo, None

SU0393

Preliminary Evidence for Acute Post-Burn Bone Resorption in Sheep Gordon Klein*1, Minyi Hu2, Liangjun Lin2, Yi-Xian Qin2, Cherry Croft3, Larry R Sumpter3, X Zhou3, H Qing4, Lynda Bonewald5. 1University of Kentucky College of Medicine, USA, 2State University of New York at Stony Brook, USA, 3University of Kentucky, USA, 4University of Missouri Dental School, USA, 5University of Missouri Kansas City, USA Disclosures: Gordon Klein, None

185

Sunday

FSH Correlates with Trabecular Bone Loss in Rats Transitioning to Ovarian Failure Ashley Lukefahr 1, Jennifer B. Frye1, Laura Wright2, Janet Funk*3. 1University of Arizona, USA, 2The University of Arizona, USA, 3University of Arizona Health Sciences Center, USA

SU0394

Regulation of Parathyroid Hormone Secretion By Caffeine-Potential Impact on Osteoporosis Ming Lu*1, Lars-Ove Farnebo2, Robert Bra¨nstro¨m 2, Catharina Larsson2. 1Karolinska Institutet, Sweden, Sweden, 2Karolinska Institutet, Sweden Disclosures: Ming Lu, None

SU0395

Response of Bone Turnover Biomarkers Following Ovariectomy In A Model of Low Birth Weight in the Female Sprague-Dawley Rat Thomas P Royals*1, Michaele B Manigrasso 1, Norma B Ojeda2, Michelle A Tucci3, Barbara T Alexander1. 1University of Mississippi School of Medicine, Department of Physiology, USA, 2University of Mississippi School of Medicine, Department of Pediatrics, USA, 3University of Mississippi School of Medicine, Department of Orthopedics, USA Disclosures: Thomas P Royals, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE STRUCTURE SU0396

Effects of Various Bone Loss Factors on Bone Micro Architecture in Female Rats Keiko Iwaki, Tomoko Hanaoka, Yasue Nishii, Hidetaka Imagita, Susumu Sakata, Akira Minematsu*. Kio University, Japan Disclosures: Akira Minematsu, None

SU0397

Influence of Vitamin D on Bone Micro-Structural and Biomechanical Properties in Patients with Hip Fracture Cristina Miranda*1, Ma Jose Montoya 2, Mercedes Giner 3, Ma Angeles Vazquez2, Ramon Perez-Cano 1. 1University of Seville, Spain, 2Virgen Macarena Hospital, Spain, 3Virgen Macarena Hospital/Seville University, Spain Disclosures: Cristina Miranda, None

OSTEOPOROSIS PATHOPHYSIOLOGY: DIETARY FACTORS SU0398

Calcium Intake Affects Body Composition, Bone Metabolism and Insuline Resistence in Spontaneously Obese Rats Clarisa Marotte*1, Gabriel Bryk 2, Marı´a Catalina Olguin3, Diego Martı´n Lucero4, Laura Schreier 4, Silvia Marı´a Friedman5, Marı´a Luz Portela6, Susana Noemı´ Zeni 7. 1Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Ca´tedra de Bioquı´mica General y Bucal, Facultad de Odontologı´a, Universidad de Buenos Aires. Consejo Nacional de Investigaciones Cientı´ficas y Te´cnicas, Argentina, 2Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Ca´tedra de Bioquı´mica General y Bucal, Facultad de Odontologı´a, Universidad de Buenos Aires, Argentina, 3Universidad Nacional de Rosario, Argentina, 4Laboratorio de Lı´pidos y Lipoproteı´nas, Departamento de Bioquı´mica Clı´nica, Hospital de Clı´nicas, Universidad de Buenos Aires, Argentina, 5Ca´tedra de Bioquı´mica General y Bucal, Facultad de Odontologı´a, Universidad de Buenos Aires, Argentina, 6Ca´tedra de Nutricio´n y Bromatologı´a, Facultad de Farmacia y Bioquı´mica, Universidad de Buenos Aires, Argentina, 7Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Ca´tedra de Bioquı´mica General y Bucal, Facultad de Odontologı´a, Universidad de Buenos Aires. Consejo Nacional de Investigaciones Cientı´ficas y Te´cnicas (CONICET), Argentina Disclosures: Clarisa Marotte, None

SU0399

Dietary Iron Deficiency is Associated with Impaired Mineralization and Osteogenic Gene Expression in Weanling Sprague Dawley Rats Edralin Lucas, MCKALE Davis, Yan Wang, Elizabeth Rendina, Stephen Clarke, Brenda Smith, Krista Shawron*. Oklahoma State University, USA Disclosures: Krista Shawron, None

SU0400

The Effect of Weight Loss and Dietary Macronutrient Composition on Bone Mineral Density - Results of a Randomized Controlled Trial Amir Tirosh*1, Vincent Carey1, Frank Sacks1, George Bray2, Steven R. Smith2, Meryl Leboff1. 1Brigham & Women’s Hospital, USA, 2Pennington Biomedical Research Center of the Louisiana State University System, USA Disclosures: Amir Tirosh, None

186

OSTEOPOROSIS PATHOPHYSIOLOGY: GLUCOCORTICOIDS SU0401

Bone Quality Is Negatively Affected by Glucocorticoid-induced Changes In the Geometry of Osteoclast Resorption Cavities Jozef Vanderoost1, Kent Soe 2, DITTE MARIE MERRILD2, Jean-Marie Delaisse3, Harry Van Lenthe*4. 1K.U.Leuven, Belgium, 2Vejle Hospital, University of Southern Denmark, Denmark, 3Vejle Hospital, CSFU-IRS, University of Southern Denmark, Denmark, 4 Katholieke Universiteit Leuven, Belgium Disclosures: Harry Van Lenthe, None

OSTEOPOROSIS PATHOPHYSIOLOGY: MALE OSTEOPOROSIS SU0402

Age-Related Changes in Proximal Humerus Bone Health in White Males Robyn Fuchs*, Sara Mantila Roosa, Andrea Hurd, Stuart Warden. Indiana University, USA Disclosures: Robyn Fuchs, None

SU0403

Poor Bone Microachitecture in Older Men with Low Muscle Mass and Grip Strength - The STRAMBO Study Stephanie BLAIZOT*1, Stephanie Boutroy2, Nicolas Vilayphiou3, Roland Chapurlat4, Pawel Szulc5. 1INSERM UMR 1033, Universite´ de Lyon, France, 2Columbia University Medical Center, New York, NY, USA, USA, 3INSERM UMR1033, Universite´ de Lyon & Hospices Civils de Lyon, France, 4E. Herriot Hospital, France, 5Hopital E. Herriot, Pavillon F, France Disclosures: Stephanie BLAIZOT, None

OSTEOPOROSIS PATHOPHYSIOLOGY: MISCELLANEOUS SU0404

Bone Mineral Density and Skeletal Microarchitecture in Small-Fiber Polynueropathy Anne Louise Oaklander1, Ruchit Kumbhani2, Erica Siwila-Sackman 2, Heather Downs1, Benjamin Leder*3. 1Department of Neurology, Massachusetts General Hospital, USA, 2 Endocrine Unit, Massachusetts General Hospital, USA, 3Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Benjamin Leder, None

SU0405

Disclosures: Janet Pritchard, None SU0406

Decreased Renal Function but not Liver Function Overpowers the Circulating Sclerostin Level Se Hwa Kim*1, Hyeong Jin Kim1, Soo Young Yoon2, Sang Choel Lee 2, Sung-Kil Lim3, Yumie Rhee4. 1Kwandong University College of Medicine, Myongji Hospital, South Korea, 2Department of Internal Medicine, College of Medicine, Kwandong University, Myongji Hospital, South Korea, 3Yonsei University College of Medicine, South Korea, 4 Department of Internal Medicine, College of Medicine, Yonsei University, South Korea Disclosures: Se Hwa Kim, None

SU0407

Effects of Preoperative Renal Function on the Postoperative ADL of Patients with Osteoporotic Vertebral Collapse with Neurological Deficits Masafumi Kashii*1, Ryoji Yamazaki2, Tomoya Yamashita 3, Takahito Fujimori1, Yukitaka Nagamoto1, Shinya Okuda2, Takenori Oda2, Tetsuo Ohwada3, Motoki Iwasaki2, Hideki Yoshikawa1. 1Osaka University Graduate School of Medicine, Japan, 2Department of Orthopedic sugery, Osaka Rousai Hospital, Japan, 3Department of Orthopedic surgery, Kansai Rousai Hospital, Japan Disclosures: Masafumi Kashii, None

SU0408

Estrogen Prevents TZDs-induced Apoptosis in Osteoblasts Hui Sheng*. Shanghai, Fudan University, Peoples Republic of China Disclosures: Hui Sheng, None

187

Sunday

Bone Mineralization Is Not Different in Women With Long-Standing Type 2 Diabetes: A Microscopy Investigation with Quantitative Backscattered Electron Imaging(qBEI). Janet Pritchard*1, Cora Tomowich1, Alexandra Papaioannou2, Jonathan Adachi3, Stephanie Atkinson1, Lora Giangregorio4, Karen Beattie1, Justin DeBeer1, Mitchell Winemaker 1, Victoria Avram1, Henry Schwarcz1. 1McMaster University, Canada, 2 Hamilton Health Sciences, Canada, 3St. Joseph’s Hospital, Canada, 4University of Waterloo, Canada

SU0409

Osteocalcin and Residual b-Cell Function in Type 1 Diabetes Annarita Maurizi1, Rocky Strollo 2, Paolo Pozzilli2, Nicola Napoli*2. 1University Campus Biomeedico, Italy, 2University Campus Biomedico, Italy Disclosures: Nicola Napoli, None

SU0410

Serum Sclerostin Levels Correlate Positively with Bone Mineral Density at Multiple Skeletal Sites in Postmenopausal Women Faryal Mirza*1, Anne Kenny2, Pamela Taxel1, Joseph Lorenzo 1. 1University of Connecticut Health Center, USA, 2University of Connecticut, USA Disclosures: Faryal Mirza, None

SU0411

The Associations of Serum Serotonin with Bone Traits Are Age- and Gender-specific Qin Wang*1, Leiting Xu2, Decai Chen1, Alen Markku3, Sulin Cheng4. 1Dept. Endocrinology of West China Hospital, Sichuan University, China, 2University of Jyvaskyla, Finland, 3Department of Medical Rehabilitation, Oulu University Hospital & Institute of Health Sciences, University of Oulu, Finland, 4University of Jyva¨skyla¨, Finland Disclosures: Qin Wang, None

OSTEOPOROSIS TREATMENT (CLINICAL): ANABOLIC AGENTS SU0412

Comparison of the Effect of Teriparatide in Japanese and Non-Japanese Patients with Osteoporosis - Bridging Strategy Mika Tsujimoto, Kazunori Uenaka, Atsuko Iwata, Yoshihiro Higashiuchi, Hideaki Sowa*. Lilly Research Laboratories Japan, Eli Lilly Japan K.K., Japan Disclosures: Hideaki Sowa, Eli Lilly Japan K.K., 3

SU0413

Evidence for Bone Reversal Properties of KoActTM, a Novel Dietary Supplement Bahram Arjmandi*1, Shirin Hooshmand 1, Jennifer Gu2, Sara Campbell3. 1Florida State University, USA, 2AIDP, Inc., USA, 3Rutgers Univeristy, USA Disclosures: Bahram Arjmandi, None

SU0414

High Resolution Peripheral Quantitative Computed Tomography (HRpQCT) Detects Improved Trabecular Volumetric BMD and Microarchitecture in Premenopausal Women with Idiopathic Osteoporosis Treated with Teriparatide Adi Cohen*1, Stephanie Boutroy2, Emily Stein3, Xiaowei Liu3, Joan Lappe4, Robert Recker4, David Dempster 5, Hua Zhou6, Donald McMahon 3, Chiyuan Zhang5, Polly Chen5, Bin Zhou5, Ji Wang5, X. Edward Guo5, Elizabeth Shane3. 1Columbia University Medical Center, USA, 2Columbia University Medical Center, New York, NY, USA, USA, 3 Columbia University College of Physicians & Surgeons, USA, 4Creighton University Osteoporosis Research Center, USA, 5Columbia University, USA, 6Helen Hayes Hospital, USA Disclosures: Adi Cohen, None

SU0415

How to Predict a Suboptimal Response to Recombinant Parathyroid Hormone Treatment in Osteoporosis Najia Siddique*1, Martin Healy2, Choon Guan Chan3, Nessa Fallon4, John Brown Walsh3, Miriam Catherine Casey3. 1St James University Hospital, Ireland, 2central pathology lab, st.James Hospital, Ireland, 3Bone health services, st.james hospital, Ireland, 4osteoporosis & bone health clinic, St.James Hospital., Ireland Disclosures: Najia Siddique, None

SU0416

Once Yearly Zoledronic Acid After 18 months of Parathyroid Hormone (1-84) for Severe Osteoporosis Marco Invernizzi*1, Stefano Carda2, Alessio Baricich2, Maurizio Bevilacqua3, Carlo Cisari2. 1University of Eastern Piedmont, Novara, Italy, 2Department of Clinical & Experimental Medicine, University of Eastern Piedmont "A. Avogadro", Italy, 3 Endocrinology & Diabetes Unit, Department of Medicine, Luigi Sacco Hospital (Vialba)University of Milan, Italy Disclosures: Marco Invernizzi, None

SU0417

PTH (1-84) Acutely and Transiently Augments Vasodilation in the Bone Vasculature and Diminishes Osteoclast Activity in Rats Rhonda Prisby*, Jeremiah Campbell, Thomas Menezes. University of Texas at Arlington, USA Disclosures: Rhonda Prisby, None

188

SU0418

Treatment with PTH 1-84 in Male Patients with Severe Osteoporosis - Results from a Prospective 24 Month Open-Label Trial Christian Muschitz1, Judith Haschka* 2, Roland Kocijan3, Astrid Fahrleitner-Pammer4, Guenther Nirnberger5, Angela Trubrich6, Christina Bittighofer6, Heinrich Resch7. 1St. Vincent’s Hospital, Austria, 2St. Vincent Hospital Vienna, Austria, 3St.Vincent Hospital Vienna, Austria, 4Medical University Graz, Austria, 5Bioconsult Ltd, Austria, 6The VINFORCE Study Group - St. Vincent Hospital - Medical Department II, Austria, 7 Medical University Vienna, Austria Disclosures: Judith Haschka, None

OSTEOPOROSIS TREATMENT (CLINICAL): BISPHOSPHONATES SU0419

Atypical Diaphyseal Femoral Fractures Associated With Bisphosphonate Use and Severe Curved Femur: A Case Series Satoshi Sasaki*1, Yuji Kasukawa2, Yoichi Shimada2, Michio Hongo2, Naohisa Miyakoshi 2. 1Yuri-kumiai General Hospital, Japan, 2Akita University Graduate School of Medicine, Japan Disclosures: Satoshi Sasaki, None

SU0420

Atypical Femoral Fractures: From the Pain without Fracture to the Fracture without Pain Enrique Casado*, Ivonne Va´zquez, Marta Larrosa, Marı´a Garcı´a-Manrique, Jose Antonio Gonza´lez, Jordi Grataco´s. University Institute Parc Taulı´, Spain Disclosures: Enrique Casado, None

SU0421

Bone Safety of a Novel Delayed-release Risedronate 35 mg Once-a-Week Assessed by Bone Histology and Histomorphometry Robert Recker*1, Ivo Valter 2, Katre Maasalu3, Clelia Magaril4, Zulema Man5, Jose Ruben Zanchetta 6, Carlos Mautalen7, Kadri-Liina Vahula8, Paul Miller 9, Dietrich Wenderoth 10, Michael McClung11. 1Creighton University Osteoporosis Research Center, USA, 2Center for Clinical & Basic Research, Estonia, 3OCRC, Tartu University Hospital, Estonia, 4 IMAI-Research, Argentina, 5Centro Me´dico TIEMPO, Argentina, 6Instituto de Investigaciones Metabolicas (IDIM), Argentina, 7Centro de Osteopatı´as Me´dicas, Argentina, 8KLV Medical Office, Estonia, 9Colorado Center for Bone Research, USA, 10 Warner Chilcott Deutschland GmbH, Germany, 11Oregon Osteoporosis Center, USA Disclosures: Robert Recker, GSK, 2; GSK,5; Procter & Gamble,5; Roche,5; Roche, 2; Lilly,5; Amgen, 2; Procter & Gamble, 2; Lilly, 2; Merck, 5; NPS Allelix, 2; Novartis, 5; Wyeth, 2; Amgen, 5; sanofi-aventis, 2; NPS Allelix, 5; Novartis, 2; Merck, 2; Wyeth, 5

Effects of Antiresorptive Therapies on Glucose Metabolism: Results from the FIT, HORIZON and FREEDOM Trials Ann Schwartz*1, Anne Schafer2, Andrew Grey 3, Ian Reid 3, Li-Yung Lui4, Lisa Palermo1, Dennis Black1, Douglas Bauer1, Eric Vittinghoff 1, Robert B. Wallace5, Steven Cummings6. 1 University of California, San Francisco, USA, 2University of California, San Francisco & the San Francisco VA Medical Center, USA, 3University of Auckland, New Zealand, 4 California Pacific Medical Center Research Institute, USA, 5University of Iowa, USA, 6 San Francisco Coordinating Center, USA Disclosures: Ann Schwartz, Merck, GlaxoSmithKline, 2; Amgen, GlaxoSmithKline, 5

SU0423

Effects of Combination therapy (Alendronate with Alfacalcidol) on Osteoporotic Fractures for Postmenopausal Japanese Women: The Japanese Osteoporosis Intervention Trial (JOINT) 02 Hiroaki Ohta*1, Masataka Shiraki2, Toshitaka Nakamura3, Masao Fukunaga4, Takayuki Hosoi5, Yukari Uemura6, Tatsuhiko Kuroda7, Nobuaki Miyakawa7, Yasuo Ohashi6, Hajime Orimo8. 1Tokyo Women’s Medical University, Sanno Medical Center, Japan, 2 Research Institute & Practice for Involutional Diseases, Japan, 3University of Occupational & Environmental Health, Japan, 4Kawasaki Medical School, Japan, 5 National Center for Geriatrics & Gerontology, Japan, 6Department of Biostatistics, School of Public Health, The University of Tokyo, Japan, 7Public Health Research Foundation, Japan, 8Japan Osteoporosis Foundation, Japan Disclosures: Hiroaki Ohta, None

189

Sunday

SU0422

SU0424

Effects of Monthly Risedronate with Cholecalciferol on 25-hydroxyvitamin D Level and Bone Markers in Korean Patients with Osteoporosis Sung-hwan Moon1, HYOUNG MOO PARK2, Chan Soo Shin3, Ho-Yeon Chung*4, YoonSok Chung5, Byung-koo Yoon6, Jae-Suk Chang7, Moo-Il Kang8, Jin-Young Park9, HyunKoo Yoon10. 1Yonsei University, South Korea, 2CHUNG-ANG UNIV. OB&GYN, Republic of Korea, 3Department of Internal Medicine, Seoul National University College of Medicine, South Korea, 4Kyung Hee University, South Korea, 5Ajou University School of Medicine, South Korea, 6Sungkyunkwan University, South Korea, 7Ulsan University, Asan Medical Center, South Korea, 8Seoul St. Mary’s Hospital, South Korea, 9Konkuk University, South Korea, 10Cheil General Hospital & Women’s Healthcare Center, South Korea Disclosures: Ho-Yeon Chung, None

SU0425

Efficacy of Intravenous Ibandronate in Postmenopausal Women with an Inadequate Response to Oral Bisphosphonate Ha Young Kim*1, Sung Jin Bae2, Beom-Jun Kim2, Seung Hun Lee3, Jung-Min Koh 2, Ghi Su Kim3. 1Wonkwang University Sanbon Hospital, South Korea, 2Asan Medical Center, South Korea, 3Asan Medical Center, University of Ulsan College of Medicine, South Korea Disclosures: Ha Young Kim, None

SU0426

Lessons Learned From Setting Up a Community Based IV Bisphosphonate Service Eamonn Brankin* 1, Robin Munro2, Wendy Feeney2, Margaret Yates2, Paul Mitchell3, John Hinnie4, Andrew Gallagher5, Janet Horner1, Stephen Gallacher6. 1NHS Lanarkshire, United Kingdom, 2NHS Lanarkshire Osteoporosis Service, United Kingdom, 3University of Derby, United Kingdom, 4South Glasgow Osteoporosis Service, United Kingdom, 5 Victoria Infirmary, United Kingdom, 6Southern General Hospital, United Kingdom Disclosures: Eamonn Brankin, Roche, 2; Novartis, 2

SU0427

Osteoporosis Treatment Patterns Among Medicare Beneficiaries Huifeng Yun* 1, Jeffrey Curtis1, Robert matthews1, Meredith Kilgore2, Michael Morrisey1, Nicole Wright1, Kenneth Saag1, David Becker 1, Elizabeth Delzell 1. 1University of Alabama at Birmingham, USA, 2University of Alabama At Birmingham School of Public Health, USA Disclosures: Huifeng Yun, Amgen, 2

SU0428

Relationship Between Change in Total Hip BMD in Response to Zoledronic Acid 5 mg and Pre-treatment Change in Total Hip BMD: the HORIZON-PFT Extension Study Richard Eastell*1, Lisa Palermo2, Steven Boonen3, Felicia Cosman4, Ian Reid5, Steven Cummings6, Dennis Black2. 1University of Sheffield, United Kingdom, 2University of California, San Francisco, USA, 3Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 4Helen Hayes Hospital, USA, 5University of Auckland, New Zealand, 6San Francisco Coordinating Center, USA Disclosures: Richard Eastell, Warner Chilcott, Amgen, Eli Lilly, AstraZeneca, 2; AstraZeneca, Amgen, GlaxoSmithKline, Medtronics, Nastech, Nestle, Fonterra Brands, Novartis, Ono Pharma, Eli Lilly, Sanofi Aventis, Tethys, Unilever, Unipath, Inverness Medical, 5

SU0429

The Effect of One Year Bi-monthly Ibandronate on Bone Mineral Density and Bone Turn Over Marker in Korean Postmenopausal Women. Young Goo Shin*. Wonju College of Medicine, South Korea Disclosures: Young Goo Shin, None

SU0430

Weekly Alendronate Versus a Single Infusion of Zoledronic Acid: Effects on Bone Turnover Markers, Areal and Volumetric BMD and Bone Microarchitecture During the First Year After Heart or Liver Transplantation Adi Cohen*1, Emily Stein2, Stephanie Boutroy3, Donald McMahon2, Chiyuan Zhang4, Polly Chen 4, Kavita Pandit1, Donna Mancini1, Robert Brown1, Susan Restaino1, Elizabeth Shane2. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University Medical Center, New York, NY, USA, USA, 4Columbia University, USA Disclosures: Adi Cohen, None

190

OSTEOPOROSIS TREATMENT (CLINICAL): COMPLIANCE AND PERSISTENCE SU0431

Bisphosphonate Prescribing, Persistence and Cumulative Exposure in Ontario, Canada Andrea Burden*1, J. Michael Paterson2, Daniel Solomon3, Muhammad Mamdani 1, David N. Juurlink1, Suzanne Cadarette1. 1University of Toronto, Canada, 2Institute for Clinical Evaluative Sciences, Canada, 3Harvard Medical School, USA Disclosures: Andrea Burden, None

SU0432

Case Study: Osteoporosis in Cosenza (Clabria, Italy). Alfonso Reda*1, Claudia Carbone2, Luisa Gallo2, Maria Gabriella Bartoletti3, Brunella Piro4. 1Italy, 2Servizio Farmaceutico Territoriale, Italy, 3Centro Riabilitazione Biolife, Italy, 4Ufficio di Farmacovigilanza Servizio Farmaceutico, Italy Disclosures: Alfonso Reda, None

SU0433

Comparative Analysis of Clinical Outcomes in Patients with Osteoporotic Vertebral Compression Fractures (OVCF); Conservative Treatment Vs Balloon Kyphoplasty Seong-Hwang Moon1, Seung Woo Suh2, Hwan Mo Lee 3, Si Young Park*4, Jae Young Hong2. 1Yonsei University College of Medicine, South Korea, 2Korea University, College of Medicine, South Korea, 3Yonsei University, College of Medicine, South Korea, 4Korea University, Medical College, South Korea Disclosures: Si Young Park, None

SU0434

Compliance with Intravenous Zoledronate in Elderly Patients with Osteoporosis Young-Kyun Lee*1, Yong-Chan Ha2, Deog-Yoon Kim3, Jae-Suk Chang4, Hyun-Koo Yoon5, Kyung-Hoi Koo 1. 1Seoul National University Bundang Hospital, South Korea, 2 Chung-Ang University Hospital, South Korea, 3Kyung Hee University Hospital, South Korea, 4Ulsan University, Asan Medical Center, South Korea, 5Cheil General Hospital & Women’s Healthcare Center, South Korea Disclosures: Young-Kyun Lee, None

SU0435

Does FRAXH change Treatment Decision in Patients visiting a German University Hospital? Susanne Rendl1, Peter Schneider*2. 1University Clinic Wu¨rzburg, Germany, 2Clinic for Nuclear Medicine, Germany Disclosures: Peter Schneider, None

SU0436

Disclosures: Suzanne Cadarette, None SU0437

Osteoporosis Telephonic Intervention to Improve Medication Adherence (OPTIMA): A Large Pragmatic Randomized Controlled Trial Daniel Solomon*1, Maura Iversen2, Jerry Avorn2, Timothy Gleeson2, Alan Brookhart3, Amanda Patrick2, Laura Rekedal2, William Shrank2, Joyce Lii 2, Elena Losina2, Jeffrey Katz2. 1Harvard Medical School, USA, 2Brigham & Women’s Hospital, USA, 3University of North Carolina, USA Disclosures: Daniel Solomon, Amgen, 2

SU0438

Post Fracture Osteoporosis Treatment Program, is it Efficient? Elena Segal*1, Marina Nodelman1, Doron Norman1, Michael Soudry1, Daniela Militianu 1, Sophia Ish-Shalom2. 1Rambam Health Care Campus, Israel, 2Rambam Health Care Campus, Technion Faculty of Medicine, Israel Disclosures: Elena Segal, Novartis, 99; Eli Lilly, 99; Merck, 99

191

Sunday

Osteoporosis Medication Prescribing in British Columbia and Ontario: Impact of Public Drug Coverage Suzanne Cadarette* 1, Diana Baek1, Nadia Gunraj2, Greg Carney 3, Michael Paterson2, Colin Dormuth3. 1University of Toronto, Canada, 2Institute for Clinical Evaluative Sciences, Canada, 3University of British Columbia, Canada

SU0439

Psychometric Properties of the Osteoporosis-Specific Morisky Medication Adherence Scale (OS-MMAS) in Postmenopausal Women With Osteoporosis (OP) Treated with Bisphosphonates (BP) Kristi Reynolds* 1, Hema Viswanathan2, Cynthia O’Malley2, Paul Muntner3, Teresa Harrison1, T. Craig Cheetham4, Jin-Wen Hsu1, Deborah Gold 5, Stuart Silverman6, Andreas Grauer7, Donald Morisky8. 1Kaiser Permanente Southern California, USA, 2 Amgen Inc., USA, 3University of Alabama at Birmingham, USA, 4Kaiser Permanente Pharmacy Analytic Services, USA, 5Duke University Medical Center, USA, 6Cedars-Sinai/ UCLA, USA, 7Amgen Health Center, USA, 8University of California, Los Angeles, USA Disclosures: Kristi Reynolds, Amgen Inc., 2

OSTEOPOROSIS TREATMENT (CLINICAL): GONADAL STEROIDS AND SERMS SU0440

Reduced BMD and Osteoporosis in Men Treated for Hypogonadism Mario Rui Mascarenhas* 1, Ana Paula Barbosa2, Anto´nio Gouveia de Oliveira3, Ana Gonc¸alves4, Vera Simo˜es5, David Santos Pinto6, M Bicho7, Isabel do Carmo8. 1Faculdade de Medicina Lisboa, Portugal, 2Endocrinology University Clinic & Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), CEDML - Endocrinology, Diabetes & Metabolism Clinic, Lda., Endocrinology, Diabetes & Metabolism Department, Santa Maria Hospital, CHLN-EPE, Portugal, 3Biostatistics Department, FCMUNL, Portugal, 4 Endocrinology, Diabetes & Metabolism Department, Santa Maria Hospital, CHLN-EPE, Romania, 5Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), CEDML - Endocrinology, Diabetes & Metabolism Clinic, Lda., Portugal, 6CEDML Endocrinology, Diabetes & Metabolism Clinic, Lda., Portugal, 7Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), Portugal, 8Endocrinology, Diabetes & Metabolism Department, Santa Maria Hospital, CHLN-EPE, Portugal Disclosures: Mario Rui Mascarenhas, None

SU0441

The Efficacy of Bazedoxifene in Postmenopausal Women is Independent from Kidney Function Rene Rizzoli*1, Silvano Adami2, Amy Levine3, Santosh Sutradhar4, Arkadi Chines 4. 1 University Hospital, Switzerland, 2University of Verona, Italy, 3Pfizer, USA, 4Pfizer Inc., USA Disclosures: Rene Rizzoli, Nestle´, Amgen, Novartis, Servier, Roche, 8; Danone, Servier, Amgen, Novartis, Roche, Nycomed, 5

OSTEOPOROSIS TREATMENT (CLINICAL): HEALTH ECONOMICS SU0442

Adherence to Osteoporosis Medications in Men: A Systematic Review of the Literature Robyn VonMaltzahn1, Heather Wieffer1, Seema Patel1, Nicole Yurgin*2. 1HERON Evidence Development Ltd, United Kingdom, 2Amgen Inc, USA Disclosures: Nicole Yurgin, Amgen Inc, 5

SU0443

Medication Adherence in Patients on Osteoporosis Therapy: Physician Perceptions Versus Patient Behavior Qian Cai1, Jeffrey Curtis2, Sally Wade3, Hema Viswanathan4, Jeff White5, Akhila Balasubramanian6, Joel Kallich4, John Adams7, BRAD STOLSHEK*6. 1HealthCore, Inc, USA, 2University of Alabama at Birmingham, USA, 3Wade Otucomes Research & Consulting, USA, 4Amgen Inc., USA, 5Wellpoint, USA, 6Amgen Inc, USA, 7RAND Corporation, USA Disclosures: BRAD STOLSHEK, HealthCore, 3

SU0444

Womens Attitudes toward Screening for Osteoporosis (Risk-stratified Osteoporosis Strategy Evaluation) Mette Rothmann*1, Lotte Huniche 2, Jette Ammentorp 3, Kim Brixen4, Anne Pernille Hermann1. 1Department of Endocrinology, Odense University Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark, 2Institute of Public Health, University of Southern Denmark, Denmark, 3Institute of Regional Health Services Research, University of Southern Denmark, Denmark, 4Institute for Clinical Research, Denmark Disclosures: Mette Rothmann, None

192

OSTEOPOROSIS TREATMENT (CLINICAL): OTHER AGENTS SU0445

Baseline Fracture Probabilities Using the WHO FRAXH Tool in a Phase 3 Study of a Novel Oral Recombinant Salmon Calcitonin John Kanis1, Helena Johansson1, Christine Buben2, James Gilligan 2, David Krause*2. 1 WHO Collaborating Centre for Metabolic Bone Diseases, United Kingdom, 2Tarsa Therapeutics, USA Disclosures: David Krause, None

SU0446

Bone Loss Caused by Anticonvulsants: BMD Improvement Using Strontium Ranelate Ilenia Pepe*1, Giuseppin Campisi1, F Scozzari1, Nicola Napoli2, Giovambattista Rini3, Gaetana Di Fede1. 1University of Palermo, Italy, 2University Campus Biomedico, Italy, 3 Department of Clinical Medicine, Italy Disclosures: Ilenia Pepe, None

SU0447

Delayed Healing of a Sub-Prosthetic Fracture of the Femoral Shaft after Prolonged Alendronate Therapy: Treatment with Teriparatide Emanuela Raimondo1, Marco Massarotti2, Carlo Eugenio Zaolino3, Andrea Fossali3, Luca Pietrogrande* 4. 1A.O. San Paolo, Italy, 2IRCCS Humanitas Clinical Institute, Italy, 3 Universita` Statale degli Studi di Milano, Italy, 4Universita` degli Studi di Milano, Italy Disclosures: Luca Pietrogrande, None

SU0448

Effects of Folic Acid and B Vitamin Supplementation on Fracture Risk in Women: Results of a Large Randomized Trial Douglas Bauer*1, JoAnn Manson2, Li-Yung Lui3, Deborah Kado4, William G. Christen5, Ara Sarkissian5, Margarette Haubourg5, Steven Cummings 6, Katie Stone7. 1University of California, San Francisco, USA, 2Harvard Medical School, USA, 3California Pacific Medical Center Research Institute, USA, 4University of California, Los Angeles, USA, 5 Harvard University, USA, 6San Francisco Coordinating Center, USA, 7California Pacific Medical Center-Research Institute, USA Disclosures: Douglas Bauer, None

SU0449

Effects of Vitamin K or Bisphosphonate on Serum Undercarboxylated Osteocalcin In Osteoporosis Patients Hiroshi Yonezu*. Department of orthopaedic surgery, Mitoyo General Hospital, Japan Disclosures: Hiroshi Yonezu, None

Long-term Effects of Angiotensin Converting Enzyme Inhibitor (ACEI) on Femur Neck BMD of Men in the Health Aging and Body Composition Study Nahid Rianon*1, Claudia Pedroza2, Melissa Garcia 3, Ann Schwartz4, Frances Tylavsky5, Jane Cauley6, Brendan Lee7, Tamara Harris8. 1UTHealth The University of Texas Medical School at Houston, USA, 2UT Houston Medical School, USA, 3NIA/NIH, USA, 4 University of California, San Francisco, USA, 5University of Tennessee, Memphis, USA, 6 University of Pittsburgh Graduate School of Public Health, USA, 7Baylor College of Medicine & Howard Hughes Medical Institute, USA, 8Intramural Research Program, National Institute on Aging, USA Disclosures: Nahid Rianon, None

SU0451

Prevention of Hip Fractures with a Multifactorial Educational Program in Elderly Finnish Women: A Population-Based, Long-Term Controlled Clinical Trial Tuula Pekkarinen*1, Eliisa Lo¨yttyniemi2, Matti Valimaki3. 1Peijas Hospital, Finland, 2 Turku University, Finland, 3Helsinki University Central Hospital, Finland Disclosures: Tuula Pekkarinen, None

SU0452

The Effect of Vitamins K on Bone Density and Fractures in Postmenopausal Women: Should There Be More Studies? Olga Gajic-Veljanoski* 1, George Tomlinson2, Ahmed M. Bayoumi3, Zoe Agnidis1, Angela Cheung1. 1University Health Network, Canada, 2University of Toronto & University Health Network, Toronto, Canada, 3University of Toronto & St. Michael’s Hospital, Toronto, Canada Disclosures: Olga Gajic-Veljanoski, None

193

Sunday

SU0450

OSTEOPOROSIS TREATMENT (CLINICAL): QUALITY OF LIFE SU0453

Acute Bone Marker Responses to Whole-Body Vibration and Resistance Exercise in Young Women Debra Bemben*, Vanessa Sherk, Carmen Chrisman, Kaelin Young, Jessica Smith, Harshvardhan Singh, Michael Bemben. University of Oklahoma, USA Disclosures: Debra Bemben, None

SU0454

Balloon-Sacroplasty on Patients with Osteoporotic Fatigue Fractures Reimer Andresen* 1, Sebastian Radmer2, Peter Kamusella 3, Christian Wissgott3, Jan Banzer4, Hans-Christof Schober5. 1Westku¨stenklinikum Heide, Germany, 2Zentrum fu¨r Bewegungsheilkunde, Berlin, Germany, 3Westku¨stenklinkum Heide, Germany, 4Charite´ Universita¨tsmedizin Berlin, Germany, 5Klinikum Su¨dstadt Rostock, Germany Disclosures: Reimer Andresen, None

SU0455

Development of a Comorbidity Index Using the FREEDOM Trial in Women With Postmenopausal Osteoporosis Stuart Silverman* 1, Andrea Wang2, Hema Viswanathan 2, Yu-Ching Yang2, Cesar Libanati3, Michelle Geller 2, Luanda Grazette4, Andreas Grauer5, David Macarios 2, Michael Nevitt6, Dennis Revicki7, Ethel Siris 8, Steven Boonen9. 1Cedars-Sinai/UCLA, USA, 2Amgen Inc., USA, 3Amgen Inc, USA, 4University of Southern California, USA, 5 Amgen Health Center, USA, 6University of California, San Francisco, USA, 7United BioSource Corporation, USA, 8Columbia University College of Physicians & Surgeons, USA, 9Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium Disclosures: Stuart Silverman, Amgen Inc, Genentech, Eli Lilly, Novartis, Pfizer, Wyeth, Roche Pharmaceuticals, Roche Diagnostics, Warner Chilcott, 5; Eli Lilly, Pfizer, Wyeth, Warner Chilcott, 2; Amgen Inc, Eli Lilly, Novartis, Pfizer, Wyeth, Roche Pharmaceuticals, 8

OSTEOPOROSIS TREATMENT (CLINICAL): VITAMIN D AND METABOLITES SU0456

Effects of Maitake Mushroom VitaminD2 Supplementation on Serum vitamin D Level and Bone Metabolic Markers in Postmenopausal Women Noriaki Yamamoto*. Niigata rehabilitation hospital, Japan Disclosures: Noriaki Yamamoto, None

SU0457

Evaluation of a 1,25D-Dihydroxy Vitamin D Assay on the IDS-iSYS Automated System Sybille Bergmann*1, Michael Gardner2, Chris Roffe2, Chris Fox2, Zoltan Seres 2, David Laurie2. 1TUD UKD Institute of Clinical Chemistry & Laboratory Medicine, Germany, 2 Immunodiagnostic Systems Limited, United Kingdom Disclosures: Sybille Bergmann, None

SU0458

Vitamin D Deficiency and Repletion: Effect of Ethnicity and BMI Amer Budayr*1, Joan Lo2, Rita Hui2, Ashley Coates2, Moxie Stratton-Loeffler2, Malini Chandra2, Jerome Minkoff2. 1Permanente Medical Group, USA, 2Kaiser Permanente, USA Disclosures: Amer Budayr, None

SU0459

Vitamin D Status does not Affect Bone Mineral Density Response to Raloxifene with Coadministration of Alfacalcidol Itsuo Gorai*1, Yasuhisa Iwaoki2. 1Sanikukai Hori Hospital, Japan, 2Department of Obstetrics & Gynecology, JA Yoshida General Hospital, Japan Disclosures: Itsuo Gorai, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): ANABOLIC AGENTS SU0460

Inhibition of Gut Serotonin Synthesis Normalizes Bone Mass In Lrp5-Deficient Mice And Other Models of Osteoporosis Hiroyuki Inose1, Bin Zhou2, Vijay Yadav2, X Guo 2, Gerard Karsenty2, Patricia Ducy*2. 1 Tokyo Medical & Dental University, Japan, 2Columbia University, USA Disclosures: Patricia Ducy, None

SU0461

Development of an Osteopenic Bone Fracture Model Kellie Brune*1, Hong Liu2, Christopher Bull2, Jeffrey Wolos3, Rachel Reams 2. 1Covance Laboratories, Inc., USA, 2Covance Laboratories, Inc., USA, 3Scientific Consultant, USA Disclosures: Kellie Brune, None

194

SU0462

Effect of PTH 1-84 on the Remodeling, Microstructure and Bone Mass In Male Orchidectomized Rats Marta Martı´n-Ferna´ndez*1, Manuel Dı´az-Curiel2, David Guede3, Jose´ Ramo´n Caeiro4, Concha de la Piedra1, Elena Martinez5. 1Bioquı´mica Investigacio´n, Instituto de Investigacio´n Sanitaria Fundacio´n Jime´nez Dı´az, Spain, 2Internal Medicine, Instituto de Investigacio´n Sanitaria Fundacio´n Jime´nez Dı´az, Spain, 3Trabeculae, Parque Tecnolo´gico de Galicia, Spain, 4Cirugı´a ortope´dica y Traumatologı´a, Complejo Hospital Universitario de Santiago de Compostela, Spain, 5Director Me´dico, Spain Disclosures: Marta Martı´n-Ferna´ndez, None

SU0463

Increased Alveolar Bone Mass in Sclerostin Knockout Mice Min Liu*1, Xianglong Han 2, Pam Kurimoto1, Jerry Feng2, Paul Dechow2, Hua Zhu Ke1. 1 Amgen Inc., USA, 2Baylor College of Dentistry, Texas A & M Health Science Center, USA Disclosures: Min Liu, Amgen Inc., 3; Amgen Inc., 1

SU0464

Inhibition of Sclerostin by Monoclonal Antibody Enhances Bone Healing in a Rat Osteotomy Model Yi-Xin He*1, Zhong Liu1, Tao Tang1, Li-Zhen Zheng1, Chi-Wai Man1, Chao-Yang Li 2, Ge Zhang1, Hua-Zhu Ke2, Ling Qin1. 1The Chinese University of Hong Kong, Hong Kong, 2 Amgen Inc., USA Disclosures: Yi-Xin He, Amgen Inc., 2

SU0465

Vitamin K2 Improves Renal Function and Increases Femoral Bone Strength in Rats with Renal Insufficiency Jun Iwamoto* 1, Azusa Seki2, Hideo Matsumoto1. 1Keio University School of Medicine, Japan, 2Hamri Co., Ltd, Japan Disclosures: Jun Iwamoto, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): BISPHOSPHONATES SU0466

Disclosures: Raquel Silva, None SU0467

Is Alendronate Effective in Improving Material Properties of Frail Cortical Bone in Inactive Model Rats? Mitsutoshi Suto 1, Kouji Naruse1, Kentaroo Uchida1, Kaori Suto1, Ken Urabe1, Moritoshi Itoman2, Yuko Mikuni-Takagaki*3. 1Department of Orthopedic Surgery, Kitasato University School of Medicine, Japan, 2Kyushu Rosai Hospital, Japan, 3Kanagawa Dental College & Graduate School of Dentistry, Japan Disclosures: Yuko Mikuni-Takagaki, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): CALCIUM AND DIETARY FACTORS SU0468

First-In-Human Study of Transdermal Salmon Calcitonin - Pharmacokinetics and Pharmodynamics YAEL KENAN* 1, Efrat Kochba2, Galit Levin3, Keren Greenfeld-Barsky2, Keren Mevorat2, Hagit Sacks2, Hana Gadasi2, Yael Leshem2, Francis Berenbaum 4, Virginia Kraus5. 1TRANSPHARMA MEDICAL LTD., Israel, 2TransPharma Medical, Israel, 3 Transpharma-Medical, Israel, 4Saint-Antoine hospital, AP-HP, France, 5Duke University Medical Center, USA Disclosures: YAEL KENAN, Transpharma Medical, Ltd, 3; Transpharma Medical, Ltd, 1

SU0469

Interaction of Calcium Intake and Vitamin D Status throughout Young Adulthood and OVXInduced Estrogen Deficiency on Bone and Calcium Metabolism Clara Park*, James Fleet, George McCabe, Connie Weaver. Purdue University, USA Disclosures: Clara Park, None

195

Sunday

Alendronate Systemic Administration: Effects on Bone and Mineralized Dental Structures Marilia Lucisano1, Raquel Silva*2, Roberto Silva3, Raquel Gerlach1, Paulo Nelson-Filho1, Ricardo Battaglino 4, Monica Serra1, Leslie Morse5, Lea Silva1. 1School of Dentistry of Ribeirao Preto - University of Sao Paulo, Brazil, 2School of Dentistry of Ribeira˜o Preto University of Sa˜o Paulo, Brazil, 3School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo, Brazil, 4The Forsyth Institute, USA, 5Harvard Medical School, USA

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): GONADAL STEROIDS AND SERMS SU0470

Non-nuclear ERa Signaling Prevents Oxidative Stress and the Loss of Bone, but not the Loss of Uterine Weight, in OVX Mice Shoshana M. Bartell*1, Li Han1, Srividhya Iyer1, Aaron Warren1, Randal S. Shelton1, Robert W. Bradsher1, Sung H. Kim2, Benita S. Katzenellenbogen 2, Ken L. Chambliss3, Philip W. Shaul3, John A. Katzenellenbogen2, Paula K. Roberson1, Robert S. Weinstein1, Charles A. O’Brien1, Robert L. Jilka1, Maria Jose S. Almeida1, Stavros C. Manolagas 1. 1 Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA, 2University of Illinois, USA, 3University of Texas Southwestern Medical Center, USA Disclosures: Shoshana M. Bartell, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): OTHER AGENTS SU0471

Effects of Low Intensity Pulsed Ultrasound on OVX Induced Bone Mass Decrease in Mice Yoshitsugu Kojima1, Takayuki Watanabe 1, Hiroki Yazawa1, Hiroyoshi Nishi2, Nobuo Izumo2, Yoshihiro Nishimura*1. 1Nippon Sigmax Co., Ltd., Japan, 2Yokohama College of Pharmacy, Japan Disclosures: Yoshihiro Nishimura, Nippon Sigmax Co., Ltd., 3

SU0472

Effects of Parathyroid Hormone, Alendronate and Their Combination Regimen on Bone Mass and Turnover in Ovariectomized Cathepsin K Null Mice Michael Gentile*1, Carlyle Horrell 2, Maureen Pickarski2, Le Thi Duong3. 1Merck & Co, USA, 2Merck & Co., Inc., USA, 3Merck Research Laboratories, USA Disclosures: Michael Gentile, None

SU0473

Efficacy of ONO-5334, a Cathepsin K Inhibitor, on Bone Mineral Density, Geometry and Bone Strength in the Radius in Ovariectomized Cynomolgus Monkeys Satoshi Nishiwaka*1, Hiroyuki Yamada1, Yasutomo Nakanishi1, Akiko Kunishige 1, Yasuaki Hashimoto1, Hiroshi Mori2, Yasuo Ochi1, Masafumi Sugitani1, Kazuhito Kawabata 1. 1Ono Pharmaceutical Co., Ltd., Japan, 2Ono Pharmaceutical Co.,Ltd., Japan Disclosures: Satoshi Nishiwaka, None

SU0474

MIV-711, a Potent and Selective Oral Once Daily Cathepsin K Inhibitor, Reduces Markers of Bone Resorption While Maintaining Carboxylated and Undercarboxylated Osteocalcin Levels in Dogs Subjected to Partial Medial Meniscectomy, an Experimental Model of Osteoarthritis Erik Lindstrom1, Lotta Vrang1, Susanne Sedig1, Ylva Terelius1, Kristina Wikstrom1, BrittLouise Sahlberg2, Timothy Chambers3, Don Maul4, Alison Bendele 5, Urszula Grabowska* 6. 1Medivir AB, Sweden, 2Medivir, Sweden, 3St. George’s Hospital Medical School, United Kingdom, 4Pre-Clinical Research Services, USA, 5Bolder Biopath, USA, 6 Medivir, United Kingdom Disclosures: Urszula Grabowska, None

SU0475

Pre-operative Intermittent Administration of Human Parathyroid Hormone Enhances Bone Union at the Site of Cancellous Bone Osteotomy in Ovariectomized Rats Hiroyuki Tsuchie*1, Naohisa Miyakoshi1, Yuji Kasukawa1, Hiroshi Aonuma2, Toyohito Segawa1, Daisuke Kudo1, Yoichi Shimada1. 1Akita University Graduate School of Medicine, Japan, 2Akita University Graduate School of Medicine, Jpn Disclosures: Hiroyuki Tsuchie, None

SU0476

Strontium Ranelate Rebalances Adipogenesis and Osteoblastogenesis and Attenuates Bone Loss in Senescent Osteopenic Mice through NFATc/Maf and Wnt Signaling Zuzana Saidak1, Eric Hay2, Caroline Marty1, Alain Barbara1, Pierre Marie*3. 1Inserm U606 & University Paris Diderot, France, 2INSERM 4606, France, 3INSERM Unit 606 & University Paris Diderot, France Disclosures: Pierre Marie, Servier, 2

196

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): VITAMIN D AND METABOLITES SU0477

Eldecalcitol (ED-71) Increases Bone Formation and Strength of Cortical Bone in Osteoporotic Mouse Model Sadaoki Sakai*1, KOICHI ENDO2, Keisuke Tanaka1, Masahiko Mihara1. 1Chugai Pharmaceutical Co., LTD., Japan, 2Chugai Pharmaceutical Co.,Ltd, Japan Disclosures: Sadaoki Sakai, CHUGAI PHARMACEUTICAL CO., LTD, 3

STEROID HORMONES AND RECEPTORS: CALCIUM-SENSING RECEPTORS SU0478

Impact of Allosteric Modulators of the Extracellular Calcium-Sensing Receptor on Human Calcitonin-Secreting C-cells Hee Chang Mun*1, Arthur Cristopoulos 2, Arthur Conigrave 1. 1University of Sydney, Australia, 2 Monash University, Australia Disclosures: Hee Chang Mun, None

STEROID HORMONES AND RECEPTORS: SEX STEROIDS SU0479

Bone Mineral Values And Sex Hormones Related To Maturity In Adolescent Females Rita Gruodyte*1, Jaak Ju¨rima¨e 2, Toivo Ju¨rima¨e 2, Adam Baxter-Jones1. 1University of Saskatchewan, Canada, 2University of Tartu, Estonia Disclosures: Rita Gruodyte, None

SU0480

Estrogens Attenuate Osteocyte Apoptosis via Activation of the NO/cGMP/PKG Pathway Nisha Marathe*, Hema Rangaswami, Gerry Boss, Renate Pilz. UCSD, USA Disclosures: Nisha Marathe, None

SU0481

Flaxseed, Alone or Combined with Low-Dose Estrogen Therapy Has No Adverse Effect on Uterus Health in Ovariectomized Rats Sandra Sacco*1, Jessica J.M. Jiang2, Lilian U. Thompson 2, Wendy Ward2. 1University of Toronto, Switzerland, 2University of Toronto, Canada Disclosures: Sandra Sacco, None

SU0482

Disclosures: Paula Stern, None SU0483

Reduced Bone Mass and Muscle Strength in Male 5a-Reductase Type 1 Inactivated Mice Sara Windahl1, Klara Sjogren*2, Niklas Andersson3, Anna Borjesson2, Charlotte Swanson2, Johan Svensson2, Sofia Moverare Skrtic4, Marie Lagerquist1, Claes Ohlsson 2. 1 Center for Bone & Arthritis Research, Sweden, 2CENTRE FOR BONE & ARTHRITIS RESEARCH, Sweden, 3Sahlgrenska University Hospital, Sweden, 4Center for Bone & Arthritis Research at the Sahlgrenska Academy, Sweden Disclosures: Klara Sjogren, None

STEROID HORMONES AND RECEPTORS: VITAMIN D AND ITS ANALOGS SU0484

24,25(OH)2 Vitamin D Levels Are Elevated in Dialysis Patients Marta Christov*1, Nigel Clarke2, Richard Reitz2, Julia Wenger1, Ravi Thadhani 1, Harald Jueppner1. 1Massachusetts General Hospital, USA, 2Quest Diagnostics, Inc., Nichols Institute, USA Disclosures: Marta Christov, None

SU0485

An Immunoassay for Free 25 Hydroxy Vitamin D Mike Martens*1, Frans Rosmalen2, Leon Swinkels1, Erik Harbers3, George Parsons4. 1 Future Diagnostics, The Netherlands, 2Future Diagnostics BV, The Netherlands, 3Future Diagnostics, Netherlands, 4Parsons Group LLC, USA Disclosures: Mike Martens, Future Diagnostics, 4; Future Diagnostics, 3

197

Sunday

Gender-Specific Effects of Estrogen and Androgen on Gene Expression in Human MonocyteDerived Osteoclasts Jun Wang1, Paula Stern*2. 1Northwestern University, USA, 2Northwestern University Medical School, USA

SU0486

Immunoassay for 25 hydroxy vitamin D Leon Swinkels*1, Antwan Maas 2, Mike Martens1, Frans Rosmalen3. 1Future Diagnostics, The Netherlands, 2Future Diagnostics, Netherlands, 3Future Diagnostics BV, The Netherlands Disclosures: Leon Swinkels, future diagnostics, 3

SU0487

Mechanisms Involved in Altered Calcium Homeostasis in the Klotho Knockout Mouse Leila J. Mady*1, Puneet Dhawan2, Angela Porta3, Makoto Kuro-o4, Sylvia Christakos1. 1 University of Medicine & Dentistry & New Jersey - New Jersey Medical School, USA, 2 UMDNJ, USA, 3Kean University, USA, 4The University of Texas Southwestern Medical Center at Dallas, USA Disclosures: Leila J. Mady, None

SU0488

Multiple Sclerosis and Chronic Diseases Is More Frequent in Young Adults Born in Summer Versus Winter – An Effect of Vitamin D Status? Susanna Streym Thomsen*, Lars Rejnmark, Leif Mosekilde, Peter Vestergaard. Aarhus University Hospital, Denmark Disclosures: Susanna Streym Thomsen, None

SU0489

Novel Mechanism of Negative Regulation of 1,25-Dihydroxyvitamin D3 Induced 24(OH)ase Transcription: Epigenetic Modification Involving Crosstalk Between Protein Arginine Methyltransferase 5 and the SWI/SNF Complex. Sneha Joshi*1, Tanya Seth2, Puneet Dhawan3, Said Sif 4, Sylvia Christakos2. 1UMDNJNJMS, USA, 2University of Medicine & Dentistry & New Jersey - New Jersey Medical School, USA, 3UMDNJ, USA, 4Ohio State University, USA Disclosures: Sneha Joshi, None

SU0490

Role of TAF12 in the Increased VDR Activity in Paget’s Disease of Bone Jumpei Teramachi*1, Huiling Cao1, Jolene Windle2, G. David Roodman3, Noriyoshi Kurihara1. 1University of Pittsburgh & The Center for Bone Biology at UPMC, USA, 2 Virginia Commonwealth University, USA, 3University of Pittsburgh, The Center for Bone Biology at UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Jumpei Teramachi, None

SU0491

Serum 25OHD Changes Following High Rates of Sun Exposure in Young Subjects with Pigmented Skin Living in the Tropics Estela Carvalho1, Amanda Melo1, Lara Voss1, Daniele Fontan2, Narriane Holanda3, Francisco Bandeira*4. 1Agamenon Magalha˜es Hospital, Brazil, 2Brazil, 3Agamenon Magalhaes Hospital, Bra, 4UPE, Brazil Disclosures: Francisco Bandeira, None

SU0492

The Efficacy of High-Dose Oral Vitamin D3 Administered Once a Year: Is the Increased Risk of Falls Attributable To Changes in Muscle Strength? Kerrie Sanders* 1, Amanda L Stuart1, Elizabeth J Williamson 1, Julie A Simpson1, Mark Kotowicz2, Geoffrey Nicholson 3. 1University of Melbourne, Australia, 2Barwon Health, Australia, 3The University of Queensland, Australia Disclosures: Kerrie Sanders, None

SU0493

The Vitamin D Analog Eldecalcitol (ED-71) Is a Potent Regulator of Intestinal Phosphate Absorption and NaPi-IIb Alex Brown*1, Cynthia Ritter2. 1Washington University in St. Louis School of Medicine, USA, 2Washington University School of Medicine, USA Disclosures: Alex Brown, Chugai Pharmaceuticals, 2

SU0494

U-shaped Association of Mortality With Serum Levels of Vitamin D, Calcium and Parathyroid Hormone in Primary Health Care Patients, Denmark Darshana Durup*1, Henrik Jørgensen2, Peter Schwarz3, Anne-Marie Heegaard1, Bent Lind4. 1Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, 2 Department of Clinical Biochemistry, Bispebjerg Hospital, Denmark, 3Glostrup Hospital, Denmark, 4Copenhagen General Practitioners Laboratory, Denmark Disclosures: Darshana Durup, None

198

SU0495

Vitamin D Binding Protein and Monocyte Responsivity to 25-hydroxyvitamin D and 1,25Dihydroxyvitamin D: Analysis by Mathematical Modeling Rene Chun*1, Brad Peercy2, Arthur Sherman3, John Adams4, Martin Hewison5. 1 Orthopedic Hospital Research Center, UCLA, USA, 2Dept. Mathematics & Statistics, University of Maryland at Baltimore County, USA, 3NIDDK - LBM - Math Cell Modelling Section, USA, 4University of California, Los Angeles, USA, 5UCLA, USA Disclosures: Rene Chun, None

MEET-THE-PROFESSOR SESSIONS 1:00 pm - 2:00 pm

Rooms 24A-26B

SOST Modulation of Bone Strength and Fracture Repair Room 24A Michael S. Ominsky, Ph.D. Amgen, Incorporated, USA Disclosures: Michael Ominsky, Amgen, Inc. 1; Amgen, Inc. 3

BMP Signaling in Skeletal Homeostasis and Fracture Repair Room 24B Vicki Rosen, Ph.D. Harvard School of Dental Medicine, USA Disclosures: Vicki Rosen, Regeneron Pharmaceuticals 5; CollPlant 5

NPY Receptor Signaling in the Regulation of Bone Mass Room 24C Paul A. Baldock, Ph.D. Garvan Institute of Medical Research, Australia Disclosures: Paul Baldock, None

The Primary Cilium and Mesenchymal Cell Fate Room 25A Christopher R. Jacobs, Ph.D. Columbia University, USA Disclosures: Christopher Jacobs, NIH 2

Sunday

Managing Bone Loss in Anorexia Nervosa Room 25B Supported by an educational grant from Merck & Co., Inc. Anne Klibanski, M.D. Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Anne Klibanski, None

Using Bone Markers in Clinical Practice Room 25C Richard Eastell, M.D., FRCP University of Sheffield, United Kingdom Disclosures: Richard Eastell, IDS 5

Premenopausal Bone Loss Room 26A Robert R. Recker, M.D. Creighton University Osteoporosis Research Center, USA Disclosures: Robert Recker, Lilly 5; NPS Allelix 2; Glaxo Smith Kline 5; Sanofi-Aventis 2; Wyeth, Procter & Gamble 2; Glaxo Smith Kline 2; Novartis 5; Merck 2; Roche 2; Procter & Gamble 5; Amgen 5; Novartis 2; Amgen 2; Merck 5; Lilly 2; Roche 5; NPS Allelix 5; Wyeth 5

Osteogenesis Imperfecta Room 26B Francis H. Glorieux, M.D., Ph.D. Shriners Hospital for Children and McGill University, Canada Disclosures: Francis Glorieux, None

Brendan Lee, M.D., Ph.D. Baylor College of Medicine & Howard Hughes Medical Institute, USA Disclosures: Brendan Lee, Biomarin 5

199

BIOTECHNIQUES WORKSHOP: MOUSE MODELS Sponsored by the ASBMR Education Committee 1:00 pm - 2:00 pm

Room 29ABCD

Chair Stavroula Kousteni, Ph.D. Columbia University Medical Center, USA Disclosures: Stavroula Kousteni, None

1:00 pm

New Approaches in Engineering Mouse Models of Human Disease Aris N. Economides, Ph.D. Regeneron Pharmaceuticals, Inc., USA Disclosures: Aris Economides, None

1:30 pm

Mouse Modeling of Human Disease in the Post-genomic Era: Resources for Research Kent C. Lloyd, DVM, Ph.D. University of California, Davis, USA Disclosures: Kent Lloyd, None

CLINICAL ROUNDTABLE/CASE CONFERENCE - MANAGING MUSCULOSKELETAL DISEASE IN CHRONIC RENAL INSUFFICIENCY 1:00 pm - 2:00 pm

Room 20BCD

Chair Susan M. Ott, M.D. University of Washington Medical Center, USA Disclosures: Susan Ott, None

1:00 pm

CKD and Bone Disease in Adults Paul D. Miller, M.D., FACP Colorado Center for Bone Research, USA Disclosures: Paul Miller, None

1:30 pm

CKD and Bone Disease in Children Mary B. Leonard, M.D. Children’s Hospital of Philadelphia, USA Disclosures: Mary Leonard, Amgen 5

SPECIAL SESSION: WHEN A REPORTER CALLS: HOW TO COMMUNICATE YOUR RESEARCH TO THE NEWS MEDIA 1:00 pm - 2:00 pm

Room 32AB

A phone call from a news reporter can spur fear or anxiety. Yet such a call can just as easily be an opportunity for researchers to communicate the meaning of their work to new and important audiences. In this session, Carol Schadelbauer of Burness Communications will demonstrate the power of message and storytelling in talking with reporters and others. Using interactive exercises and video clips of actual interviews, we will explore how to be memorable in any setting, and in particular with the media. Carol Schadelbauer Burness Communications, USA Disclosures: Carol Schadelbauer, None

200

CONCURRENT ORAL SESSION 19: STEROID HORMONES AND RECEPTORS 2:15 pm - 3:45 pm

Room 20A

Moderators: Daniel D. Bikle, M.D., Ph.D. Endocrine Research Unit, Division of Endocrinology UCSF, USA Disclosures: Daniel Bikle, None

David G. Monroe, Ph.D. Mayo Foundation, USA Disclosures: David Monroe, None

2:15 pm 1109

2011 ASBMR MOST OUTSTANDING BASIC ABSTRACT AWARD Targeted Disruption of the Glucocortioid Receptor in Adipocytes Results in, an Osteosclerotic Phenotype, Increased Fat Mass and Growth Retardation in Mice Yaqing Zhang1, Jinwen Tu1, Julian Kelly1, Tara Brennan-Speranza 1, Alexander Rauch2, Colin Dunstan3, Jan Tuckermann2, Markus Seibel4, Dr. Hong Zhou*4. 1Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 2Tissue specific Hormone Action, Leibniz Institute for Age Research, Fritz Lipmann Institute, Germany, 3 University of Sydney, Australia, 4Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Dr. Hong Zhou, None

2:30 pm 1110

ERa-deletion from Osteoblast Progenitors Abolishes the Protective Effect of Estrogens on Cortical Bone Mass in Both Female and Male Mice Srividhya Iyer*, Shoshana Bartell, Aaron Warren, Li Han, Marta Martin-Millan, Elena Ambrogini, Jinhu Xiong, Robert Weinstein, Robert Jilka, Charles O’Brien, Maria Almeida, Stavros Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Srividhya Iyer, None

2:45 pm 1111

2011 ASBMR YOUNG INVESTIGATOR AWARD MKP-1 in Canonical 1,25(OH)2D3-signaling and Skeletal Homeostasis Alfred Griffin*, Keith Kirkwood. Medical University of South Carolina, USA

3:00 pm 1112

The VDR Interacts Directly with Mediators of Hegehog Signaling: Implications for the Development of Alopecia in VDR Null Mice. Francesca Gori*1, Hilary Luderer1, Eric Zhu2, Marie Demay2. 1Massachusetts General Hospital, USA, 2Massachusetts General Hospital & Harvard Medical School, USA Disclosures: Francesca Gori, None

3:15 pm 1113

2011 ASBMR YOUNG INVESTIGATOR AWARD Bone Formation in Mice Deficient for the Vitamin D-24-hydroxylase Gene, Cyp24a1 Abdallah Husseini*1, Alice Arabian2, Rene St-Arnaud 3. 1Shriners Hospital & McGill University, Canada, 2Shriners Hospital for Children, Canada, 3Shriners Hospital for Children & McGill University, Canada Disclosures: Abdallah Husseini, None

3:30 pm 1114

The Role of Vitamin D Receptor in Motor Function Sadaoki Sakai*1, KOICHI ENDO2, Keisuke Tanaka3, Masahiko Mihara3. 1Chugai Pharmaceutical Co., LTD., Japan, 2Chugai Pharmaceutical Co.,Ltd, Japan, 3CHUGAI PHARMACEUTICAL CO., LTD, Japan Disclosures: Sadaoki Sakai, CHUGAI PHARMACEUTICAL CO., LTD, 3

201

Sunday

Disclosures: Alfred Griffin, None

CONCURRENT ORAL SESSION 20: GROWTH FACTORS, CYTOKINES, IMMUNOMODULATORS 2:15 pm - 3:45 pm

Room 32AB

Moderators: Yin Tintut, Ph.D. University of California, Los Angeles, USA Disclosures: Yin Tintut, None

M. Neale Weitzmann, Ph.D. Emory University School of Medicine, USA Disclosures: M. Neale Weitzmann, None

2:15 pm 1115

NLRP3 Inflammasome is a Major Regulator of Bone Resorption Sheri Bonar1, Matthew McGeough2, Marcus Watkins1, Susan Grimston3, Susannah Brydges2, James Mueller2, Carla Pena2, Roberto Civitelli 1, Hal Hoffman 2, Gabriel Mbalaviele* 3. 1Washington University in St. Louis School of Medicine, USA, 2University of California, San Diego, USA, 3Washington University School of Medicine, USA Disclosures: Gabriel Mbalaviele, None

2:30 pm 1116

PTH Induces Hemopoietic Stem Cell Expansion Through T Cell Produced Wnt10b Jau-Yi Li*1, Brahmchetna Bedi1, Hesham Tawfeek1, Jonathan Adams1, Timothy F. Lane2, Tatsuya Kobayashi3, M. Neale Weitzmann1, Henry Kronenberg 3, Roberto Pacifici 1. 1 Emory University School of Medicine, USA, 2University of California, Los Angeles, USA, 3 Massachusetts General Hospital, USA Disclosures: Jau-Yi Li, None

2:45 pm 1117

2011 ASBMR YOUNG INVESTIGATOR AWARD The Novel Osteoinductive Wnt Regulator NELL-1 Potently Antagonizes BMP2-induced Adipogenesis and Augments BMP2-induced Osteogensis Potently Jia Shen*1, Ronald Siu 2, Sheng Pang3, Janette Zara4, Jinny Kwak5, Xinli Zhang2, Aaron James2, Michael Chiang5, Richard Ngo 5, Weiming Li6, Min Lee7, Kang Ting2, Chia Soo3. 1 University of California, Los Angeles, California, USA, 2University of California, Los Angeles, USA, 3Department of Orthopaedic Surgery,University of California, Los Angeles, USA, 4UCLA, USA, 5School of Dentistry/Section of Orthodontics, University of California, Los Angeles, USA, 6First Clinical Hospital, Harbin Medical University Department of Orthopaedics, China, 7Division of Advanced Prosthodontics, Biomaterials & Hospital Dentistry, University of California, Los Angeles, USA Disclosures: Jia Shen, None

3:00 pm 1118

Msx2-Wnt Signaling Inhibits and Dkk1 Promotes The Endothelial-Mesenchymal Transition In Primary Aortic Endothelial Cells Su-Li Cheng*1, Dwight Towler 2. 1Washington University in St. Louis School of Medicine, USA, 2Washington University in St. Louis, USA Disclosures: Su-Li Cheng, None

3:15 pm 1119

Vascular Tissues Are a Primary Source of BMP2 Expression during Bone Formation Induced by Distraction Osteogenesis Hidenori Matsubara1, Daniel Hogan2, Douglas Mortlock3, Elise Morgan4, Thomas Einhorn5, Louis Gerstenfeld* 1. 1Boston University School of Medicine, USA, 2Boston University College of Engineering, USA, 3Vanderbilt University School of Medicine, USA, 4 Boston University, USA, 5Boston Medical Center, USA Disclosures: Louis Gerstenfeld, None

3:30 pm 1120

BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells via Interaction with Acvr2b Shoichiro Kokabu*1, Laura Gamer1, Karen Cox1, Kunikazu Tsuji2, Regina Raz3, Aris Economides 3, Takenobu Katagiri4, Vicki Rosen1. 1Harvard School of Dental medicine, USA, 2Tokyo Medical & Dental University, Japan, 3Regeneron Pharmaceuticals, Inc., USA, 4Saitama Medical University Research Center for Genomic Medicine, Japan Disclosures: Shoichiro Kokabu, None

202

CONCURRENT ORAL SESSION 21: TGF- b AND BONE PHYSIOLOGY 2:15 pm - 3:45 pm

Room 29ABCD

Moderators: Susan C. Schiavi, Ph.D., M.S. Genzyme Corporation, USA Disclosures: Susan Schiavi, None

Xu Cao, Ph.D. Johns Hopkins University, USA Disclosures: Xu Cao, None

2:15 pm 1121

TGFb Inducible Early Gene-1 Plays a Critical Role in Mediating Estrogen and Canonical Wnt Signaling in the Growing Mouse Skeleton John Hawse*1, Muzaffer Cicek2, Kevin Pitel3, Sarah Grygo4, Kenneth Peters4, Nalini Rajamannan5, Urszula Iwaniec6, Russell Turner6, Merry Jo Oursler2, Thomas Spelsberg2, Malayannan Subramaniam 2. 1Mayo Clinic College of Medicine, USA, 2Mayo Clinic, USA, 3 University of Minnesota, USA, 4Mayo Clinic College of Medicine, USA, 5Northwestern University Medical School, USA, 6Oregon State University, USA Disclosures: John Hawse, None

2:30 pm 1122

Targeted Disruption of TGFBI in Mice Reveals Novel Role for this Gene in Regulating Peak Bone Size Hongrun Yu*1, Heather Watts2, Anil Kapoor2, Yongliang Zhao3, Jon Wergedal2, Subburaman Mohan2. 1JLP Memorial VA Med Ctr, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3Center for Radiological Research, USA Disclosures: Hongrun Yu, None

2:45 pm 1123

TGF-b Type II Receptor Signaling Plays An Essential Role in Knee Development Tieshi Li*1, Lara Longobardi1, Froilan Granero-Molto1, Timothy Myers2, Douglas Mortlock3, Anna Spagnoli1. 1University of North Carolina at Chapel Hill, USA, 2 University of North Carolina, USA, 3Vanderbilt University Medical Center, USA Disclosures: Tieshi Li, None

Anti TGF-b Antibody Attenuates Increased Bone Turnover in Rodent Models of High Turnover Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) Shiguang Liu*, Wenping Song, Joseph Boulanger, Wen Tang, Christina Bracken, Sue Ryan, Robert Fogle, Yves Sabbagh, Susan Schiavi. Genzyme Corporation, USA Disclosures: Shiguang Liu, Genzyme, 3

3:15 pm 1125

TGF-b-dependent Regulation of Sclerostin during Mechanical Loading Jacqueline Nguyen*, Simon Tang, Dan Nguyen, Tamara Alliston. University of California, San Francisco, USA Disclosures: Jacqueline Nguyen, None

3:30 pm 1126

A New Role for the TGFbRII-MCP-5 Axis as a Key Regulator in the Interplay between the Articular Cartilage and the Forming Bone during Limb Development Lara Longobardi* 1, Tieshi Li 2, Timothy Myers3, Froilan Granero-Molto1, yun yan3, ying li3, Anna Spagnoli1. 1University of North Carolina at Chapel Hill, USA, 2UNC, USA, 3 UNC-CH, USA Disclosures: Lara Longobardi, None

CONCURRENT ORAL SESSION 22: METHODS OF OSTEOPOROSIS ASSESSMENT 2:15 pm - 3:45 pm

Room 31ABC

Moderators: Vicente Gilsanz, M.D. Children’s Hospital Los Angeles, USA Disclosures: Vicente Gilsanz, None

Andrew J. Burghardt University of California, San Francisco, USA Disclosures: Andrew Burghardt, None

203

Sunday

3:00 pm 1124

2:15 pm 1127

2011 ASBMR YOUNG INVESTIGATOR AWARD Precise 3D Localisation of a Cortical Thinning Defect Associated With Femoral Neck Fracture in Life Kenneth Poole*1, Graham Treece1, Paul Mayhew1, Martin Horak2, Jan Stepan3, Andrew H Gee 1. 1University of Cambridge, United Kingdom, 2Bulovka Hospital, Czech Republic, 3 Charles University, Czech Republic Disclosures: Kenneth Poole, None

2:30 pm 1128

Patterns of Prevalent and Incident Vertebral Fracture in the Spine: Differentiating Prevalent Fracture from Deformity Thomas Fuerst*1, Gabriele von Ingersleben2, Chun Wu 2, Souhila Ounadjela2, Pierre Colombel 2, Jan Szechinski3, Karina Hufert3, Harry Genant4. 1Synarc, Inc., USA, 2Synarc Inc, USA, 3Synarc Inc, Germany, 4UCSF/Synarc, USA Disclosures: Thomas Fuerst, Synarc Inc, 3

2:45 pm 1129

CT Methods That Use Thresholding Throw Out the Baby with the Bath Water Ego Seeman*1, Roger Zebaze1, Ali Ghasem-Zadeh1, Aloys Mbala2. 1Austin Health, University of Melbourne, Australia, 2Strax Corp, Australia Disclosures: Ego Seeman, None

3:00 pm 1130

External Validation of the Garvan Nomograms For Predicting Absolute Fracture Risk: the Tromsø Study ˚ shild Bjørnerem3, Ragnar M. Joakimsen 3, Lone Luai A. Ahmed*1, Nguyen Nguyen2, A 1 2 Jørgensen , Dana Bliuc , Jacqueline Center2, John Eisman2, Tuan Nguyen2, Nina Emaus4. 1 Department of Health & Care Sciences, Faculty of Health Sciences, University of Tromsø, Norway, 2Garvan Institute of Medical Research, Australia, 3Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Norway, 4University of Tromsoe, 9037 Tromso, Norway Disclosures: Luai A. Ahmed, None

3:15 pm 1131

A Long Femur Scan Field does not Substantially Alter Proximal Femur BMD measurements by DXA Neil Binkley*1, Fergus McKiernan2, Richard Berg 3, James Linneman3, Jane Hocking2, Susan Cournoyer2. 1University of Wisconsin, Madison, USA, 2Marshfield Clinic, USA, 3 Biomedical Informatics, Marshfield Clinic Research Foundation, USA Disclosures: Neil Binkley, None

3:30 pm 1132

Postmenopausal Women with Vertebral and Non-vertebral Fragility Fractures Have Marked Differences in Tibial Microarchitecture Emily Stein* 1, Thomas Nickolas2, Adi Cohen2, Donald McMahon 1, Xiaowei Liu1, Mafo Kamanda-Kosseh3, Jeri Nieves4, Felicia Cosman4, X Guo3, Elizabeth Shane1. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University Medical Center, USA, 3Columbia University, USA, 4Helen Hayes Hospital, USA Disclosures: Emily Stein, None

CONCURRENT ORAL SESSION 23: OSTEOPOROSIS TREATMENT (CLINICAL) 2:15 pm - 3:45 pm

Room 20BCD

Moderators: Laura A.G. Armas, M.D. Creighton University, USA Disclosures: Laura Armas, None

Murray J. Favus, M.D. University of Chicago, USA Disclosures: Murray Favus, None

2:15 pm 1133

Effects of Bazedoxifene/Conjugated Estrogens on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women: A Double-Blind, Randomized, Placebo- and Activecontrolled Phase 3 Study J. Christopher Gallagher*1, Robert Lindsay2, Kaijie Pan3, Sebastian Mirkin3, Arkadi Chines3. 1 Creighton University Medical Center, USA, 2Helen Hayes Hospital, USA, 3Pfizer Inc., USA Disclosures: J. Christopher Gallagher, Wyeth Advisory Board, 5; Wyeth, 2

204

2:30 pm 1134

Results of the ORACAL Trial: A Phase 3 Randomized Trial of the Safety and Efficacy of Orally Administered Recombinant Salmon Calcitonin Tablets in Postmenopausal Women with Osteoporosis Neil Binkley*1, Michael Bolognese2, James Gilligan 3, David Krause3. 1University of Wisconsin, USA, 2Bethesda Health Research, USA, 3Tarsa Therapeutics, USA Disclosures: Neil Binkley, Tarsa Therapeuitcs, 2

2:45 pm 1135

Effects of the Cathepsin K Inhibitor, ONO-5334, on BMD as Measured by 3D QCT in the Hip and the Spine After 2Years of Treatment Klaus Engelke*1, Shinichi Nagase2, Thomas Fuerst 3, Richard Eastell4, Harry Genant5, Maria Small 2, Tomohiro Kuwayama2, Steve Deacon2. 1Synarc Inc, Germany, 2ONO PHARMA UK LTD, United Kingdom, 3Synarc, Inc., USA, 4University of Sheffield, United Kingdom, 5UCSF/Synarc, USA Disclosures: Klaus Engelke, Synarc, 3

3:00 pm 1136

Controlled Trial of Two Interventions to Increase Osteoporosis Treatment in Patients with "Incidentally" Detected Vertebral Fractures on Chest Radiographs (NCT00388908) Sumit Majumdar*1, Finlay A. McAlister1, Jeffrey A. Johnson1, Debbie Bellerose1, Kerry Siminoski1, David Hanley2, Quazi Ibrahim1, Douglas A. Lier1, Robert G. Lambert1, Anthony S. Russell1, Brian H. Rowe1. 1University of Alberta, Canada, 2University of Calgary, Canada Disclosures: Sumit Majumdar, None

3:15 pm 1137

2011 ASBMR SHUN-ICHI HARADA YOUNG INVESTIGATOR AWARD The 25(OH)D Level Associated With A Favorable Bisphosphonate Response Is .33ng/ml Amanda Carmel*1, Albert Shieh1, Richard Bockman2. 1Weill Cornell Medical College, USA, 2Hospital for Special Surgery, Weill Medical College, USA Disclosures: Amanda Carmel, None

3:30 pm 1138

Early Detection of Lateral Cortical Lesions in Atypical Subtrochanteric Fracture Using Dual Energy X-ray Absorptiometry (DXA) Hip Images Kyu Hyun Yang*1, Sungjun Kim2, Young-Kyun Lee 3, HanKook Yoon4, Chang-Wug Oh5, Hyeung Keun Song1. 1Gangnam Severance Hospital, South Korea, 2Yonsei University College of Medicine Gangnam Severance Hospital, South Korea, 3Seoul National University Bundang Hospital, South Korea, 4National Health Insurance Corporation Ilsan Hospital, South Korea, 5Kyungpook National University Hospital, South Korea

CONCURRENT ORAL SESSION 24: CHILDHOOD FACTORS WITH BONE ACQUISITION 2:15 pm - 3:45 pm

Room 30CDE

Moderators: Gordon L. Klein, M.D., MPH University of Kentucky College of Medicine, USA Disclosures: Gordon Klein, None

Karen K. Winer, M.D. National Institutes of Health, NICHD, USA Disclosures: Karen Winer, None

2:15 pm 1139

2011 ASBMR YOUNG INVESTIGATOR AWARD Breastfeeding in Infancy and Bone Mass in British Children at 10 and 16 Years of Age Alexa Gallagher* 1, Jihong Liu1, Jon Tobias2, Jim Hussey1, Charlotte Atkinson2, Susan Steck1. 1University of South Carolina, USA, 2University of Bristol, United Kingdom Disclosures: Alexa Gallagher, None

2:30 pm 1140

Lumbar Spine Bone Mineral Density Is Enhanced in Breast Fed Infants Receiving 800 or 1200 IU of Vitamin D Daily from 4 to 20 Weeks of Age Sina Gallo* 1, Celia Rodd1, Catherine Vanstone1, Sherry Agellon1, Mary L’Abbe2, Ali Khamessan3, Hope Weiler1. 1McGill University, Canada, 2University of Toronto, Canada, 3 Euro-Pharm Inernaional Canada Inc., Canada Disclosures: Sina Gallo, None

205

Sunday

Disclosures: Kyu Hyun Yang, None

2:45 pm 1141

An Investigation of Relationships Between Fracture Risk, Total Body DXA And Tibial pQCT Reveals Independent Influences of Areal And Cortical BMD in Adolescence: Is There a Case For Combining DXA And pQCT In Assessing Fracture Risk? Adrian Sayers*, Chau Jacky, Kate Tilling, Jon Tobias. University of Bristol, United Kingdom Disclosures: Adrian Sayers, None

3:00 pm 1142

2011 ASBMR YOUNG INVESTIGATOR AWARD Variants in WNT16 are Strongly Associated with Total Body Mineralization in Children of Different Ethnic Background and with Total Body BMD of Elderly Adults Carolina Medina-Gomez*1, Karol Estrada2, Denise Heppe3, Lizbeth Herrera2, Rodinde Bloot2, Mette Offerhaus2, Ling Oei 2, Albert Hofman4, Vincent Jaddoe3, Paul Eliers5, Andre G Uitterlinden 2, Fernando Rivadeneira 2. 1Erasmus Medical Center, The Netherlands, 2Department of Internal Medicine, Erasmus Medical Center, Netherlands, 3 The Generation R Study Group, Erasmus Medical Center, Netherlands, 4Department of Epidemiology, Erasmus Medical Center, Netherlands, 5Department of Biostatistics, Erasmus Medical Center, Netherlands Disclosures: Carolina Medina-Gomez, None

3:15 pm 1143

Racial and Ethnic Disparity in Fracture Risk among Pediatric Populations in the United States Tishya Wren*1, John Shepherd2, Heidi Kalkwarf3, Babette Zemel4, Joan Lappe5, Sharon Oberfield 6, Karen Winer7, Vicente Gilsanz8. 1Children’s Hospital Los Angeles, USA, 2 University of California, San Francisco, USA, 3Cincinnati Children’s Hospital Medical Center, USA, 4Children’s Hospital of Philadelphia, USA, 5Creighton University Osteoporosis Research Center, USA, 6Columbia University Medical Center, USA, 7 National Institutes of Health, NICHD, USA, 8Children’s Hospital of Los Angeles, USA Disclosures: Tishya Wren, None

3:30 pm 1144

Changes in the Genetic Architecture of Bone Health during Childhood Dana L. Duren*1, Richard J. Sherwood2, Miryoung Lee 2, Maja Seselj3, Thomas Dyer4, Shelley Cole4, Roger M. Siervogel3, Stefan A. Czerwinski3, John Blangero4, Bradford Towne2. 1Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Orthopaedic Surgery, Wright State University, USA, 2 Lifespan Health Research Center, Department of Community Health, Wright State University; Department of Pediatrics, Wright State University, USA, 3Lifespan Health Research Center, Department of Community Health, Wright State University, USA, 4 Texas Biomedical Research Institute, USA Disclosures: Dana L. Duren, None

COFFEE BREAK 3:30 pm - 4:00 pm

Hall GH

CLINICAL UPDATE FOR HEALTH PROFESSIONALS – IOM REPORT ON VITAMIN D 4:00 pm - 5:30 pm Chair Ethel S. Siris, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Ethel Siris, Amgen 8; Merck 5; Eli Lilly 5; Pfizer 5; Eli Lilly 8; Amgen 5

4:00 pm

The IOM Position and Cutoff of 20 Clifford J. Rosen, M.D. Maine Medical Center, USA Disclosures: Clifford Rosen, None

4:20 pm

Musculoskeletal Health and the Cutoff of 30 Bess Dawson-Hughes, M.D. Tufts University, USA Disclosures: Bess Dawson-Hughes, None

206

Room 20BCD

4:40 pm

Vitamin D in Children Catherine M. Gordon, M.D. Children’s Hospital Boston and Harvard Medical School, USA Disclosures: Catherine Gordon, Pfizer 99; Merck 99

5:00 pm

Discussion

STATE-OF-THE-ART LECTURES - TRP CHANNEL SIGNALING IN SKELETAL PHYSIOLOGY AND MINERAL METABOLISM 4:00 pm - 5:30 pm

Room 20A

Co-Chairs Geert J.V. Carmeliet, M.D., Ph.D. Katholieke Universiteit Leuven, Belgium Disclosures: Geert Carmeliet, None

Keith A. Hruska, M.D. Washington University in St. Louis School of Medicine, USA Disclosures: Keith Hruska, None

4:00 pm

The Biology and Physiology of Epithelial Calcium and Magnesium Transport Rene Bindels, Ph.D. Radboud University Nijmegen, Disclosures: Rene Bindels, None

4:30 pm

TRP Regulation of Osteoblast and Osteoclast Physiology Geert J.V. Carmeliet, M.D., Ph.D. Katholieke Universiteit Leuven, Belgium Disclosures: Geert Carmeliet, None

5:00 pm

Molecular Genetics of TRPV4 in Chondrocyte Biology and Spondometaphyseal Dysplasia Deborah Krakow, M.D. David Geffen School of Medicine At UCLA, USA Disclosures: Deborah Krakow, None

Room 31ABC

You are invited to attend the ASBMR Town Hall Meeting and Reception at which you will learn about the Society, including the year in review, planned activities, strategic directions and leadership opportunities. Come learn more about ASBMR, meet with ASBMR leadership, ask questions during an "open-mic" time and enjoy a wine and cheese reception.

ASBMR WOMEN IN BONE AND MINERAL RESEARCH COMMITTEE EVENT – GETTING WHAT YOU WANT: THE ART OF NEGOTIATION Sponsored by the ASBMR Women in Bone and Mineral Research Committee Supported by an Educational Grant from Warner-Chilcott Company, LLC. Ticket Required 6:30 pm - 9:30 pm

Room 25ABC

This session (for everyone at all career stages) on negotiation will provide insight on the following topics: N The costs of not negotiating, in financial terms and in delayed or limited career progress N Causes associated with the reluctance to negotiate N Practical steps to start thinking differently about the role of negotiation and learn to negotiate more comfortably, confidently, and effectively A reception and dinner will be provided.

207

Sunday

ASBMR TOWN HALL MEETING AND RECEPTION 5:30 pm - 6:30 pm

7:00 pm

Getting What You Want: The Art of Negotiation Sara Laschever Co-author of Women Don’t Ask and Ask for It Disclosures: Sara Laschever, None

NON-INVASIVE ASSESSMENT OF BONE MICROARCHITECTURE AND FUNCTION WORKING GROUP Fourteenth Annual Meeting Ticket Required 6:30 pm - 8:30 pm

Room 30CDE

The working group includes a presentation and a discussion forum for researchers to exchange ideas pertaining to the technical, basic science and clinical aspects of bone microarchitecture assessment. This Fourteenth Annual Meeting will focus on microarchitecture and bone quality and cover both clinical and experimental aspects of these entities. In addition to trabecular bone architecture noninvasive imaging of cortical bone porosity and remodeling will be introduced and hr-pQCT based techniques will be presented. The goals of the working group are to initiate communication and exchange of ideas, stimulate future development and adequate support in this area, and accelerate advances in the field of non-invasive assessment of bone microarchitecture and function. 6:30 pm

Buffet Style Dinner

6:55 pm

Welcome / Introduction

7:00 pm

Imaging of Cortical Remodeling and Porosity Ego Seeman, M.D. Department of Endocrinology and Medicine, University of Melbourne,Australia

7:30 pm

Advances in Micro Finite Element Analysis Bert van Rietbergen, Ph.D. Eindhoven University of Technology, The Netherlands

8:00 pm

Submicron 3D X-ray Microscopy of Human and Rat Bone Tissue Mohammed Akhter, Ph.D. Osteoporosis Research Center, Creighton University, USA

8:30 pm

Adjourn Organizers: Thomas M. Link, MD, PhD, Department of Radiology and Biomedical Imaging, University of California, San Francisco Robert E. Guldberg, Ph.D. Bioengineering Research Group, Georgia Institute of Technology, Atlanta Marjolein C. H. van der Meulen, Ph.D. Sibley School of Mechanical & Aerospace Engineering Cornell University, Laboratory for Biomedical Mechanics & Materials, Hospital for Special Surgery

Disclosures: Bert van Rietbergen- Scanco Medical AG, 5. Mohammed Akhter- Xradia, inc, 5.

208

ADULT BONE AND MINERAL WORKING GROUP 26th Annual Meeting Supported by an educational grant from Amgen Inc. Ticket Required 6:30 pm - 9:00 pm

Room 30AB

Opening Remarks and Presentation of Boy Frame Award Chair: Pauline M Camacho, M.D. Co-Chairs: Fergus McKiernan, M.D. and Daniel Hurley, M.D.

6:45 pm

Historic Vignette: Phosphatonins Rajiv Kumar, M.D. Mayo Clinic, USA

7:00 pm

Severe Renal Osteodystrophy in a 40 Year Old Female with End Stage Renal Disease Maria Princess M. Landicho, M.D., FPCP Makati Medical Center, Philippines

7:15 pm

Familial Fibrogenesis Imperfecta Ossium (FFIO) Sanjay Kumar Bhadada PGIMER, Chandigarh, India

7:30 pm

Treatment of Tumor Induced Osteomalacia with CT-guided Percutaneous Ethanol Ablation and Percutaneous Cryoablation Joseph Shaker, M.D. Medical College Wisconsin, USA

7:45 pm

Characteristic clinical and radiologic features of Prodromal Bone Deterioration (PBD) in patients on long term bisphosphonate therapy: A case series of seven patients Manjari Devidi, M.D. St. Joseph Hospital, USA

8:00 pm

Vitamin D and Calcium Nutritional Status in Patients with Hip Fractures & Elective Joint Replacement Surgery: Preliminary Results of a Prospective Case Controlled Study Salma Makhoul-Ahwach, M.D. Henry Ford Hospital, USA

8:15 pm

Achy breaky bones: Oncogenic Osteomalacia Ishani Dalal, M.D. Henry Ford Hospital, USA

8:30 pm

Teriparatide, Vitamin D, and Calcium Healed Bilateral Subtrochanteric Stress Fractures in a Postmenopausal Woman with a 13-Year History of Continuous Alendronate Therapy Claud Arnaud, M.D. University of California, San Francisco, USA

8:45 pm

Concluding Remarks

VITAMIN D WORKING GROUP Ticket Required 6:30 pm - 9:20 pm

Room 32AB

6:45 p.m. Introductory Remarks Anthony Norman, Roger Bouillon 6:50 p.m. Randomized controlled trial determination of the vitamin D requirement during pregnancy and lactation: Dramatic divergence with 2010 IOM recommendations. Dr. Bruce Hollis, Ph.D., Dept Pediatrics, Medical University of South Carolina 7:15 p.m. Discussion

209

Sunday

6:30 pm

7:20 p.m. The association between mortality and vitamin D levels is U-shaped: A study from the Primary Healthcare of Denmark. Dr. Darshana Durup, Ph.D., Dept. Pharmacology, Univ. Copenhagen, DK 7:30 p.m. Discussion 7:35 p.m. TB or not TB: Antibacterial actions of vitamin D in human health Dr. Martin Hewison, Ph.D., UCLA Orthopaedic Hospital Research Center, Geffin School Of Medicine 8:00 p.m. Discussion 8:05 p.m. Break 8:15 p.m. Emerging actions of vitamin D in mammary gland and breast cancer: Cytokines and metabolism. JoEllen Welsh, Ph.D., Gen*NY*sis Center for Excellence in Cancer Genomics at UAlbany 8:40 p.m. Discussion 8:45 p.m. The vitamin D analog eldecalcitol (ED-71) is a potent regulator of intestinal phosphate absorption and NaPi-Hb. Alex Brown, Ph.D., Renal Division,Washington University School of Medicine 8:55 p.m. Discussion 9:00 p.m. Chronic MAPK inhibition in Hyp mice rescues disordered vitamin D metabolism and skeletal mineralization defect. Farzana Perwad, M.D., Dept. Pediatrics, School of Medicine, UC-San Francisco 9:10 p.m. Discussion 9:15 p.m. Concluding Remarks Roger Bouillon, Anthony Norman

BONE STRENGTH WORKING GROUP Sponsored by the Canadian Bone Strength Working Group Supported by an unrestricted educational grant from Amgen Canada Inc. Fourth Annual Meeting Ticket Required 6:30 pm - 9:30 pm

Room 33ABC

Co-Chairs: Jonathan Adachi, M.D. McMaster University, Canada Shawn Davison, Ph.D. University of Laval, Canada 6:30 pm

Dinner

7:00 pm

Welcome and Introduction Angela Cheung, M.D., Ph.D. University of Toronto, Canada

7:10 pm

Evolution of Bone Strength with Age: A Large Micro-Finite Element Analysis in Women from the OFELY Cohort Nicolas Vilayphiou, INSERM, France

7:22 pm

Regional Variation in Cortical Microarchitecture of the Distal Radius and Tibia Galateia Kazakia, UCSF, USA

7:34 pm

Bone Microarchitecture and Finite Element Analysis Measured with HR-pQCT can Identify Postmenopausal Women with and without Forearm Fragility Fractures Kyle Nishiyama, University of Calgary, Canada

210

7:46 pm

Parathyroidectomy Improves Bone Geometry and Microarchitecture in Female Patients with Primary Hyperparathyroidism. A 1-year Prospective, Controlled Study Using HR-pQCT Stinus Hansen, University of Southern Denmark, Denmark

8:00 pm

Cortical Bone is More Important than Trabecular Bone for Bone Strength Pro: Ego Seeman, M.D. Professor of Medicine University of Melbourne, Australia Against: Mary Bouxsein, Ph. D. Assistant Professor of Orthopedic Surgery Harvard Medical School, USA

9:00 pm

Questions and Discussion/Final Vote

9:25 pm

Concluding Remarks Richard Kremer M.D., Ph.D. McGill University Health Center, Canada

Sunday 211

Monday, September 19, 2011

MONDAY, SEPTEMBER 19, 2011 DAY-AT-A-GLANCE Time/Event/Location

All locations in the San Diego Convention Center unless otherwise noted

7:30 am - 5:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 ASBMR Registration Open Hall F 8:00 am - 4:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Posters Open Hall GH 8:00 am - 9:30 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Plenary Symposium II – Lipotoxicity: Bad to the Bone Room 20BCD 9:30 am - 4:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Exhibits Open Hall GH 9:30 am - 9:35 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Presentation of the ASBMR Paula Stern Achievement Award Room 20BCD 9:35 am - 9:40 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Presentation of the Shirley Hohl Service Award Room 20BCD 9:40 am - 10:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Coffee Break Hall GH 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216 Concurrent Oral Session 25: Osteoblasts Room 20A 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217 Concurrent Oral Session 26: Bone, Cartilage and Connective Tissue Matrix & Development Room 32AB 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218 Concurrent Oral Session 27: Osteoclasts Room 31ABC 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 Concurrent Oral Session 28: Preserving Muscle and Bone During Aging Room 20BCD 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220 Concurrent Oral Session 29: Osteoporosis Pathophysiology Room 29ABCD 10:00 am - 11:30 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 Concurrent Oral Session 30: Hormonal and Metabolic Influence on Bone Acquisition Room 30CDE 11:30 am - 1:30 pm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 Poster Session III & Poster Tours* Hall GH

212

1:30 pm - 2:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Meet-the-Professor Sessions Room 24A - Room 26A 1:30 pm - 2:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282 Advocating for Science in Challenging Times Room 20A 1:30 pm - 2:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283 Clinical Roundtable/Case Conference - Monitoring Osteoporosis Therapy – To Scan or Not to Scan? Room 20BCD 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283 Concurrent Oral Session 31: Genetic Disorders of Bone and Mineral Metabolism Room 30CDE 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 284 Concurrent Oral Session 32: Osteoclasts Room 29ABCD 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285 Concurrent Oral Session 33: Growth Factors, Cytokines, Immunomodulators Room 32AB 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 286 Concurrent Oral Session 34: Anabolic Treatment for Osteoporosis Room 20BCD 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 Concurrent Oral Session 35: Wnt Pathway and Osteoporosis Treatment Room 20A 2:45 pm - 4:15 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 288 Concurrent Oral Session 36: Metabolic Influences in the Pathophysiology of Osteoporosis Room 31ABC 4:00 pm - 4:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Coffee Break Hall GH 4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Concurrent Oral Session 37: Osteoblasts Room 20A 4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 290 Concurrent Oral Session 38: Bone, Cartilage and Connective Tissue Matrix & Development Room 30CDE

4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 292 Concurrent Oral Session 40: Skeletal Loading and Bone Quality Room 31ABC 4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293 Concurrent Oral Session 41: Risk of Typical and Atypical Fractures Room 29ABCD 4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294 Concurrent Oral Session 42: New Aspects of Standard Osteoporosis Treatment Room 20BCD 6:15 pm - 8:45 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 Molecular Biology and Pathology of Bone Working Group Room 31ABC Ticket Required

213

Monday

4:30 pm - 6:00 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 Concurrent Oral Session 39: Cancer and Bone (Basic, Translational and Clinical) Room 32AB

6:30 pm - 8:40 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 296 Working Group on Musculoskeletal Rehabilitation in Patients with Osteoporosis Room 30AB Ticket Required 6:30 pm - 8:30 pm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297 Working Group on Osteoporosis in Rheumatic Diseases Room 30CDE Ticket Required

214

ASBMR REGISTRATION OPEN 7:30 am - 5:00 pm

Hall F

POSTERS OPEN 8:00 am - 4:30 pm

Hall GH

PLENARY SYMPOSIUM II – LIPOTOXICITY: BAD TO THE BONE Dedicated to the Life and Memory of Etsuro Ogata, M.D., Ph.D. Supported by an Educational Grant from Chugai Pharmaceutical Co., Inc. 8:00 am - 9:30 am

Room 20BCD

Co-Chairs Ann V. Schwartz, Ph.D. University of California, San Francisco, USA Disclosures: Ann Schwartz, GlaxoSmithKline 2; Merck 2; GlaxoSmithKline 5; Amgen 5

Beata Anna Lecka-Czernik, Ph.D. University of Toledo College of Medicine, USA Disclosures: Beata Lecka-Czernik, None

8:00 am

Fat and Bone: Location, Location, Location! Clifford J. Rosen, M.D. Maine Medical Center, USA Disclosures: Clifford Rosen, None

8:30 am

Ox-lipids in Bone: Their Formation and Impact on Osteoblasts and Osteoclasts Linda L. Demer, M.D., Ph.D. David Geffen School of Medicine At University of California Los Angeles, USA Disclosures: Linda Demer, None

9:00 am

The Role of Lipid Oxidation in the Pathophysiology and Treatment of Osteoporosis Robert L. Jilka, Ph.D. University of Arkansas for Medical Sciences, USA Disclosures: Robert Jilka, Radius Health, Inc. 1

EXHIBITS OPEN Hall GH

PRESENTATION OF THE ASBMR PAULA STERN ACHIEVEMENT AWARD 9:30 am - 9:35 am

Room 20BCD

PRESENTATION OF THE SHIRLEY HOHL SERVICE AWARD 9:35 am - 9:40 am

Room 20BCD

COFFEE BREAK 9:40 am - 10:00 am

Hall GH

215

Monday

9:30 am - 4:30 pm

CONCURRENT ORAL SESSION 25: OSTEOBLASTS 10:00 am - 11:30 am

Room 20A

Moderators: William W. Lu The University of Hong Kong, Hong Kong Disclosures: William Lu, None

Gabriel Mbalaviele, Ph.D. Washington University in St. Louis School of Medicine, USA Disclosures: Gabriel Mbalaviele, None

10:00 am sFrp4 Differentially Regulates Trabecular and Cortical Bone Mass via Canonical Wnt and 1145 Ror2-BMP-Sclerostin Signaling, Respectively Hiroaki Saito* 1, Eric Hesse 2, Kei Yamana3, Riku Kiviranta4, Lynn Neff5, Nicolas Solban6, William Horne1, Roland Baron7. 1Harvard School of Dental Medicine, USA, 2Harvard Schools of Medicine & Dental Medicine, USA, 3Teijin Pharma Limited, Japan, 4Medical Biochemistry & Genetics & Turku PET Centre, University of Turku, Finland, 5Harvard School of Dental Medicine, Oral Medicine, Infection & Immunity, USA, 6Acceleron Pharma, USA, 7Harvard School of Medicine & of Dental Medicine, USA Disclosures: Hiroaki Saito, None

10:15 am Conditional Ca2+-Sensing Receptor Knockouts in Mature Osteoblasts and Osteocytes Reveal 1146 Critical Roles for this Molecule in Maintenance of Bone Mass and Facture Healing. Wenhan Chang1, Zhiqiang Cheng1, Tsui Hua Chen1, Nathan Liang2, Michael You2, Alfred Li2, Chialing Tu 1, Christian Santa Maria2, Dolores Shoback*3. 1University of California, San Francisco, USA, 2VA Medical Center, San Francisco, USA, 3VA Medical Center, USA Disclosures: Dolores Shoback, None

10:30 am In vivo Multiphoton Imaging of Mesenchymal Stem Cell-Mediated Skeletal Repair 1147 Chunlan Huang, Ming Xue, Xinping Zhang*. University of Rochester Medical Center, USA Disclosures: Xinping Zhang, None

10:45 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1148 N-cadherin Interferes with LRP5/6-PTH Receptor Association Leila Revollo*3, Valerie Salazar1, Jin Norris2, Gabriel Mbalaviele 1, Roberto Civitelli 3. 1 Washington University School of Medicine, USA, 2Washington University in St. Louis, USA, 3Washington University in St. Louis School of Medicine, USA Disclosures: Leila Revollo, None

11:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1149 BMP Type II Receptors Further Stimulate Constitutively Activated Mutant ALK2 found in Fibrodysplasia Ossificans Progressiva Satoshi Ohte*1, Hiroki Sasanuma2, Masashi Shin1, Katsumi Yoneyama2, Seiya Suzuki2, Toru Fukuda3, Shoichiro Kokabu4, Takenobu Katagiri2. 1Saitama Medical University, Japan, 2Saitama Medical University Research Center for Genomic Medicine, Japan, 3Keio University School of Medicine, Japan, 4Harvard School of Dental medicine, USA Disclosures: Satoshi Ohte, None

11:15 am In Vivo Effect of Bone-Specific EphB4 Overexpression in Mice on Subchondral Bone and 1150 Cartilage during Osteoarthritis Gladys Valverde-Franco*1, Mohit Kapoor1, David Hum1, Koichi Matsuo2, Bertrand Lussier3, Jean-Pierre Pelletier1, Johanne Martel-Pelletier1. 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Canada, 2School of Medicine, Keio University, Japan, 3University of Montreal, Faculty of Veterinary Medicine, Clinical Sciences, Canada Disclosures: Gladys Valverde-Franco, None

216

CONCURRENT ORAL SESSION 26: BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX & DEVELOPMENT 10:00 am - 11:30 am

Room 32AB

Moderators: Di Chen, M.D., Ph.D. University of Rochester Medical Center, USA Disclosures: Di Chen, None

Anne-Marie Heegaard, M.D., Ph.D. Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark Disclosures: Anne-Marie Heegaard, None

10:00 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1151 Functional Redundancy of GSK-3a and GSK-3b to Control Chondrocyte Differentiation through Phosphorylation of RelA/NF-kB p65 Shozo Itoh*1, Taku Saito2, Makoto Hirata3, Masahiro Ushita1, Toshiyuki Ikeda4, Kozo Nakamura 3, Ung-Il Chung5, Hiroshi Kawaguchi6. 1University of Tokyo, Japan, 2 University of Tokyo, Graduate School of Medicine, Japan, 3The University of Tokyo, Japan, 4Information Technology Services, Inc., Japan, 5University of Tokyo Graduate Schools of Engineering & Medicine, Japan, 6University of Tokyo, Faculty of Medicine, Japan Disclosures: Shozo Itoh, None

10:15 am 2011 ASBMR FELIX BRONNER YOUNG INVESTIGATOR AWARD 1152 Runx2 Regulates Axin2 Modulation of Mesenchymal Stem Cell Fate in Cranial Sutures Meghan McGee-Lawrence*1, Amel Dudakovic1, David Razidlo1, Wei Hsu 2, Jane Lian3, Jennifer Westendorf1. 1Mayo Clinic, USA, 2URMC, USA, 3University of Massachusetts Medical School, USA Disclosures: Meghan McGee-Lawrence, None

10:30 am PTHrP Regulates the Modeling of Cortical Bone and Ligament and Tendon Insertion Sites 1153 During Linear Growth. Joshua VanHouten*1, Randy L. Johnson2, Guoying Liang3, Arthur Broadus1. 1Yale University School of Medicine, USA, 2M.D. Anderson Cancer Center, USA, 3Yale University, USA Disclosures: Joshua VanHouten, None

Disclosures: Tatsuya Kobayashi, None

11:00 am The Transcription Factor Arid5B Is a Novel Partner of Sox9 in Endochondral Bone 1155 Formation Rikako Takashima* 1, Kenji Hata1, Makoto Wakabayashi 1, Masako Nakanishi 1, Koichiro Ono1, Katsuhiko Amano1, Robert Whitson2, Yoshinobu Maeda1, Riko Nishimura 1, Toshiyuki Yoneda1. 1Osaka University Graduate School of Dentistry, Japan, 2Beckman Research Institute of City of Hope, USA Disclosures: Rikako Takashima, None

11:15 am Direct Role of Nkx3.2 to Promote the Primary Chondrocytic Differentiation 1156 Yoshitaka Kawato*1, Makoto Hirao2, Kosuke Ebina1, Hiroki Oze1, Shoichi Kaneshiro1, Kenrin Shi1, Akira Myoui3, Hideki Yoshikawa1, Jun Hashimoto 4. 1Osaka University Graduate School of Medicine, Japan, 2Department of Orthopaedics, National Hospital Organization Osaka Minami Medical Center, Japan, 3Osaka University Hospital, Japan, 4 Center of Immune Diseases, National Hospital Organization Osaka Minami Medical Center, Japan Disclosures: Yoshitaka Kawato, None

217

Monday

10:45 am Deficiency of EED, a Critical Component of the Polycomb Repressor Complex 2, Causes Cell 1154 Death Due to Competitive Inhibition of HIF1a by aryl Hydrocarbon Receptor in Chondrocytes Erinn Rankin1, Jennifer Inloes2, Huafeng Xie3, Stuart Orkin3, Ernestina Schipani4, Tatsuya Kobayashi* 2. 1MGH, USA, 2Massachusetts General Hospital, USA, 3Children’s Hospital Boston & Dana-Farber Cancer Institute, USA, 4Massachusetts General Hospital & Harvard Medical School, USA

CONCURRENT ORAL SESSION 27: OSTEOCLASTS 10:00 am - 11:30 am

Room 31ABC

Moderators: F. Patrick Ross, Ph.D. Hospital for Special Surgery, USA Disclosures: F. Patrick Ross, None

Roberta Faccio, Ph.D. Washington University in St Louis School of Medicine, USA Disclosures: Roberta Faccio, None

10:00 am OC-STAMP and DC-STAMP are both essential for cell-cell fusion in osteoclasts and foreign 1157 body giant cells Kazuhiro Chiba1, Hiroya Miyamoto* 2, Takeshi Miyamoto 3, Yoshiaki Toyama1, Hideo Morioka1. 1Department of Orthopedics, University of Keio, Japan, 2University of Keio, Japan, 3Keio University School of Medicine, Japan Disclosures: Hiroya Miyamoto, None

10:15 am Notch-RBP-J Signaling Predominantly Suppresses TNF-a Induced Osteoclastogenesis and 1158 Inflammatory Bone Resorption Baohong Zhao*1, Shannon Grimes 2, Xiaoyu Hu1, Lionel Ivashkiv1. 1Hospital for Special Surgery, USA, 2Hosptial for Special Surgery, USA Disclosures: Baohong Zhao, None

10:30 am Dual Specificity Phosphatase 1 Limits Inflammatory Osteolysis 1159 Youridies Vattakuzhi*1, Sonya Abraham2, Adel Ersek2, Dany P. B. Perocheau2, Richard O. Williams2, Andy R. Clark2, Nicole Horwood2. 1Kennedy Institute of Rheumatology, Imperial College, GBR, 2Kennedy Institute of Rheumatology, United Kingdom Disclosures: Youridies Vattakuzhi, None

10:45 am Deletion of b-catenin in Osteoclast Precursors and their Progeny Increases Osteoclastogenesis 1160 and Induces Cortical Bone Loss Marta Martin Millan*1, Maria Carmen Gonza´lez-Martı´n 2, Shoshana Bartell3, Maria Jose Almeida3, Marian Ros4, Jesu´s Gonza´lez Macı´as5. 1Instituto de Formacio´n e Investigacio´n Marques Valdecilla, Esp, 2Instituto de Biomedicina y Biotecnologı´a de Cantabria, Spain, 3 University of Arkansas for Medical Sciences, USA, 4 Instituto de Biomedicina y Biotecnologı´a de Cantabria, Spain, 5Instituto de Formacio´n e Investigacio´n Marques Valdecilla, University of Cantabria, Spain Disclosures: Marta Martin Millan, None

11:00 am Osteoclast-Dependent Canalicular Formation in Cortical Bone That Mediates Bone 1161 Remodeling Nobuhito Nango*1, Shogo Kubota1, Wataru Yashiro2, Atsushi Momose 2, Yasunari Takada3, Koichi Matsuo3. 1Ratoc System Engineering Co., Ltd., Japan, 2Department of Advanced Materials Sciences, School of Frontier Sciences, The University of Tokyo, Japan, 3 School of Medicine, Keio University, Japan Disclosures: Nobuhito Nango, None

11:15 am Selective Deletion of the Receptor for CSF1, c-fms, in Mature Osteoclasts Results in a High 1162 Bone Mass Phenotype In Vivo but a Normal Response to an Anabolic PTH Regimen Meiling Zhu*1, Ben-hua Sun1, Karl Insogna2. 1Yale University, USA, 2Yale University School of Medicine, USA Disclosures: Meiling Zhu, None

218

CONCURRENT ORAL SESSION 28: PRESERVING MUSCLE AND BONE DURING AGING 10:00 am - 11:30 am

Room 20BCD

Moderators: Douglas P. Kiel, M.D., MPH Hebrew SeniorLife, USA Disclosures: Douglas Kiel, None

Robert Pignolo, M.D., Ph.D. University of Pennsylvania, USA Disclosures: Robert Pignolo, None

10:00 am Three Monthly, Oral 150,000 IU Cholecalciferol Supplementation Effects on Falls, Mobility 1163 and Muscle Strength in Older Postmenopausal Women Paul Glendenning*1, K Zhu2, Peter Howat3, Charles Inderjeeth4, Joshua Lewis5, Richard Prince6. 1Royal Perth Hospital, Australia, 2School of Medicine & Pharmacology, Australia, 3 CBRCC, Curtin University, Australia, 4University of Western Australia, Australia, 5The University of Western Australia, Australia, 6Sir Charles Gairdner Hospital, Australia Disclosures: Paul Glendenning, None

10:15 am Sclerostin Mediates the Skeletal Effects of Weight Loss and Exercise Therapy In Obese Older 1164 Adults Reina Armamento-Villareal*1, Corinn Sadler1, Suresh Chode2, Nicola Napoli3, Clifford Qualls1, Krupa Shah4, David Sinacore5, Dennis Villareal1. 1University of New Mexico School of Medicine, USA, 2St. Mary’s Hospital, USA, 3University Campus Biomedico, Italy, 4University of Rochester School of Medicine, USA, 5Washington University in St. Louis, USA Disclosures: Reina Armamento-Villareal, None

10:30 am Multi-Phenotype Genome-Wide Association Meta-Analysis on both Lean Body Mass and 1165 BMD Identified Novel Pleiotropic Genes that Affected Skeletal Muscle and Bone Metabolism in European Descent Caucasian Populations Yi-Hsiang Hsu*1, Xing Chen2, Carola Zillikens3, Karol Estrada4, Serkalem Demissie5, Ching-Ti Liu6, Yanhua Zhou7, David Karasik8, Joanne Murabito9, Andre Uitterlinden10, L. Adrienne Cupples5, Fernando Rivadeneira4, Douglas Kiel8. 1Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 2Harvard University, USA, 3Erasmus University Medical Center, Netherlands, 4Erasmus University Medical Center, The Netherlands, 5Dept. Biostatistics, Boston University, School of Public Health, USA, 6Boston University School of Public Health, USA, 7Boston University, USA, 8Hebrew SeniorLife, USA, 9Boston University Medical School, USA, 10Rm Ee 575, Genetic Laboratory, The Netherlands Disclosures: Yi-Hsiang Hsu, None

Disclosures: Robin Daly, None

11:00 am Systemic Administration of Soluble Activin Receptors Produces Differential Anabolic Effects 1167 in Muscle and Bone in Mice Douglas Digirolamo*, Vandana Singhal, Thomas Clemens, Se-Jin Lee. Johns Hopkins University, USA Disclosures: Douglas Digirolamo, None

11:15 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1168 Combined Deletion of the Transcription Factors FoxO1, 3, and 4 from Osteoblast Progenitors Expressing Osterix Causes Bone Anabolism and Postpones the Adverse Effects of Aging on Bone Srividhya Iyer*, Elena Ambrogini, Li Han, Shoshana Bartell, Aaron Warren, Randall Shelton, Robert Weinstein, Charles O’Brien, Stavros Manolagas, Maria Almeida. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Srividhya Iyer, None

219

Monday

10:45 am Effects of High Velocity Power and Functional Training on BMD and Physical Function in 1166 High Risk Older Adults: A 12-month Randomised Controlled Trial Jenny Gianoudis1, Christine Bailey 2, Peter Ebeling2, Caryl Nowson3, Kerrie Sanders4, Keith Hill 5, Robin Daly*3. 1Department of Medicine, The University of Melbourne, Australia, 2The University of Melbourne, Australia, 3Centre for Physical Activity & Nutrition Research, Deakin University, Australia, 4University of Melbourne, Australia, 5 School of Physiotherapy, La Trobe University, Australia

CONCURRENT ORAL SESSION 29: OSTEOPOROSIS PATHOPHYSIOLOGY 10:00 am - 11:30 am

Room 29ABCD

Moderators: Robert L. Jilka, Ph.D. University of Arkansas for Medical Sciences, USA Disclosures: Robert Jilka, None

Benjamin Z. Leder, M.D. Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Benjamin Leder, None

10:00 am Hyponatremia Causes Bone Loss and Sarcopenia 1169 Nikhil Sharma1, Joseph G Verbalis2, Michael B Manigrasso1, Helen Tam 1, Julia (Julianna) Barsony*2, Qin Xu1. 1Georgetown University, USA, 2Georgetown University Hospital, USA Disclosures: Julia (Julianna) Barsony, None

10:15 am Arrest of the Reversal Phase in Postmenopausal and Glucocorticoid-Induced Osteoporosis 1170 Pia Jensen*1, Thomas Andersen2, Mohamed Abdelgawad 3, Ellen Hauge4, Jens Bollerslev5, Jean-Marie Delaisse6. 1Vejle Hospital, Denmark, 2Vejle Hospital, IRS-CSFU, University of Southern Denmark, Denmark, 3Clinical Cell Biology Department, Vejle Hospital, Denmark, 4Aarhus University Hospital, Denmark, 5National University Hospital, Norway, 6 Vejle Hospital, CSFU-IRS, University of Southern Denmark, Denmark Disclosures: Pia Jensen, None

10:30 am FSH is Associated with Lean Mass and Fat Mass but not with BMD in Younger 1171 Postmenopausal Women Margaret Gourlay*1, Chenxi Li2, Catherine Hammett-Stabler2, Jordan Renner2, Janet Rubin3. 1University of North Carolina at Chapel Hill, USA, 2University of North Carolina, USA, 3University of North Carolina, Chapel Hill, School of Medicine, USA Disclosures: Margaret Gourlay, None

10:45 am Calcium Deficiency-induced Bone Loss is Exacerbated by Disruption of Claudin-18 Gene in 1172 Mice Gabriel R. Linares*1, Catrina Alarcon 2, Robert Brommage3, David Powell4, Weirong Xing2, Jon Wergedal2, Subburaman Mohan2. 1Jerry L Pettis VA Med Ctr, USA, 2Jerry L. Pettis Memorial VA Medical Center, USA, 3Lexicon Pharmaceuticals, USA, 4Lexicon Pharamaceuticals, USA Disclosures: Gabriel R. Linares, None

11:00 am Increased Density of Capillaries and Dividing Cells at Remodeling Sites in Adult Human Bone 1173 Helene Kristensen*1, Thomas Andersen2, Prof. Niels Marcussen3, Lars Rolighed4, JeanMarie Delaisse 5. 1Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark, Denmark, 2Vejle Hospital, IRS-CSFU, University of Southern Denmark, Denmark, 3Odense University Hospital, Denmark, 4Aarhus University Hospital, Denmark, 5Vejle Hospital, CSFU-IRS, University of Southern Denmark, Denmark Disclosures: Helene Kristensen, None

11:15 pm Peripheral Blood Monocyte-Expressed Anxa2 Gene Is Involved in Pathogenesis of 1174 Osteoporosis in Humans Fei Yan Deng*1, Shu-Feng Lei2, Yan Zhang3, Yu-Ling Zhang4, Yan-Peng Zheng5, Li-Shu Zhang5, Yunxia (Yesha) Lundberg6, Yao-Zhong Liu7, Christopher Papasian8, Hong-Wen Deng1. 1Tulane University, USA, 2College of Life Sciences, Hunan Normal University, China, 3Department of Genetics, Boys Town National Research Hospital, USA, 4Center of Systematic Biomedical Research, University of Shanghai for Science & Technology, China, 5 College of Life Sciences & Bioengineering, Beijing Jiaotong University, China, 6Boys Town National Research Hospital, USA, 7Center of Bioinformatics & Genomics, Tulane University School of Public Health & Tropical Medicine, USA, 8School of Medicine, University of Missouri-Kansas City, USA Disclosures: Fei Yan Deng, None

220

CONCURRENT ORAL SESSION 30: HORMONAL AND METABOLIC INFLUENCE ON BONE ACQUISITION 10:00 am - 11:30 am

Room 30CDE

Moderators: Mary B. Leonard, M.D. Children’s Hospital of Philadelphia, USA Disclosures: Mary Leonard, None

Catherine M. Gordon, M.D. Children’s Hospital Boston and Harvard Medical School, USA Disclosures: Catherine Gordon, None

10:00 am Sex-specificity in femoral neck growth during adolescence and young adulthood: evidence from 1175 15-years of longitudinal data Saija Kontulainen* 1, Stefan Jackowski1, Joel Lanovaz2, James Johnston 1, Adam BaxterJones1. 1University of Saskatchewan, Canada, 2Assistant Professor, Canada Disclosures: Saija Kontulainen, None

10:15 am Serum Osteocalcin Levels Are Associated With Testosterone Levels In Boys During Maximal 1176 Skeletal Growth Salman Kirmani*1, Elizabeth Atkinson2, L. Joseph Melton1, Byron Riggs1, Shreyasee Amin1, Sundeep Khosla2. 1Mayo Clinic, USA, 2College of Medicine, Mayo Clinic, USA Disclosures: Salman Kirmani, None

10:30 am 2011 ASBMR YOUNG INVESTIGATOR AWARD 1177 Dose-Response Effect of Vigorous Aerobic Exercise on Bone Turnover, Insulin Sensitivity, and Adiposity in Obese Children: A Randomized Controlled Trial Norman Pollock*1, Paul Bernard2, Barbara A. Gower3, Karl Wenger 1, Sudipta Misra 1, Jerry Allison1, Alexis M. Stranahan1, Catherine L. Davis1. 1Georgia Health Sciences University, USA, 2Medical College of Georgia, USA, 3University of Alabama-Birmingham, USA Disclosures: Norman Pollock, None

10:45 am Mutant Mouse Models Reveal Indispensable Role for Thyroid Hormone (TH) Acting Via 1178 Growth Hormone (GH)-dependent and -independent Mechanisms to Regulate Bone and Fat Phenotypes during the Pre-pubertal Growth Period Weriong Xing*, Heather Davidson, Sheila Pourteymoor, Anil Kapoor, Subburaman Mohan. Jerry L. Pettis Memorial VA Medical Center, USA Disclosures: Weriong Xing, None

Disclosures: Anna Darelid, None

11:15 am Vitamin D Binding Protein Genotype Is Associated with Vitamin D Status and Bone Health in 1180 Finnish Children and Adolescents Elisa Saarnio*1, Minna Pekkinen2, Heli Viljakainen 3, Outi Makitie4, Christel LambergAllardt2. 1University of Helsinkl, Finland, 2University of Helsinki, Finland, 3Helsinki University Central Hospital for Children & Adolescents, Fin, 4Hospital for Children & Adolescents, Helsinki University Hospital, Finland Disclosures: Elisa Saarnio, None

221

Monday

11:00 am Catch Up in Bone Acquisition in Young Adult Men with Late Puberty 1179 Anna Darelid*1, Claes Ohlsson2, Martin Nilsson3, Jenny Kindblom4, Dan Mellstro¨m5, Mattias Lorentzon 5. 1Gothenburg University, Sweden, 2Centre for Bone & Arthritis Research, Sweden, 3Centre for Bone & Arthritis Research At the Sahlgrenska Academy, Sweden, 4Sahlgrenska University Hospital, Sweden, 5Center for Bone Research at the Sahlgrenska Academy, Sweden

POSTER SESSION III & POSTER TOURS* 11:30 am - 1:30 pm

Hall GH

*Poster Tours will begin at the ASBMR Networking Center at 12:00 noon

AGING AND MUSCLE/BONE INTERACTIONS: CELLULAR AND MOLECULAR MECHANISMS MO0001

Analyses of Gene Expression in hMSC Indicate Age-Associated Loss of Self-Regeneration and Function Peggy Benisch*1, So¨nke Frey 2, Lothar Seefried1, Ludger Klein-Hitpass 3, Moustapha Kassem4, Regina Ebert 5, Franz Jakob1. 1University of Wu¨rzburg, Orthopedic Center for Musculoskeletal Research, Germany, 2Hospital University Wu¨rzburg, Department of Trauma-, Hand-, Plastic- & Reconstructive Surgery, Germany, 3Hospital University Essen, Institute of Cell Biology, Germany, 4Odense University Hospital, Denmark, 5University of Wuerzburg, Orthopedic Center for Muskuloskeletal Research, Germany Disclosures: Peggy Benisch, None

MO0002

Borage and Fish Oils Lifelong Supplementations Decrease Inflammation and Improve Bone Health in a Murine Model of Senile Osteoporosis Fabien Wauquier* 1, Laurent Leotoing 2, Claire Philippe2, Elisabeth Miot Noirault3, Veronique Coxam4, Yohann Wittrant5. 1INRA, UMR 1019, UNH, CRNH Auvergne, F63009 Clermont-Ferrand, France, France, 2INRA, France, 3INSERM, France, 4INRA Theix, France, 5Institut National de la Recherche Agronomique, France Disclosures: Fabien Wauquier, None

MO0003

Botulinum Toxin Type A Does Not Directly Affect Bone Cell Viability or Differentiation Susan Grimston*1, Marcus Watkins2, Roberto Civitelli2. 1Washington University School of Medicine, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Susan Grimston, None

MO0004

Muscle Strength and its Relationship to Inflammation Markers and Antioxidants Intake in Elderly Women Patrı´cia Genaro*1, Marcelo Pinheiro 2, Ligia Martini3, Vera Szejnfeld4. 1Universidade Federal de Sa˜o Paulo, Brazil, 2Sao Paulo Federal University/ Unifesp/ Escola Paulista De Medicina, Brazil, 3University of Sa˜o Paulo, Brazil, 4UNIFESF/EPM, Brazil Disclosures: Patrı´cia Genaro, None

MO0005

Skeletal Muscle Cells Secrete Factor(s) Protecting Bone Cells from Glucocorticoid Induced Cell Death Katharina Jaehn*1, Leticia Brotto1, Nuria Lara1, Chenglin Mo1, Mark Johnson2, Marco Brotto1, Lynda Bonewald1. 1University of Missouri - Kansas City, USA, 2University of Missouri, Kansas City Dental School, USA Disclosures: Katharina Jaehn, None

AGING AND MUSCLE/BONE INTERACTIONS: FRAILTY AND SARCOPENIA MO0006

Assessment of Muscle Mass Changes and Nerve Conduction Velocity in the Rat Orchidectomy Model NANCY DOYLE*1, Aurore Varela2, Elisabeth Lesage2, Solomon Haile1, Joseph Arezzo3, Susan Y. Smith2, Hitoshi Saito4. 1CHARLES RIVER, Canada, 2Charles River Laboratories, Canada, 3Albert Einstein College of Medicine, Departments of Neuroscience & Neurology, USA, 4Chugai Pharmaceutical Company, Limited, Japan Disclosures: NANCY DOYLE, None

MO0007

Characterization of Bone Status in a Premature Aging Mouse Model Sergio Portal*1, Rashed Manassra2, Daniel Lozano3, Alicia Acitores4, Mo´nica De la Fuente2, Pedro Esbrit5. 1Spain, 2Dpto. de Fisiologı´a Animal (Fisiologı´a Animal II), UCM, Spain, 3Instituto de Investigacio´n Sanitaria-Fundacio´n Jime´nez Dı´az, Spain, 4Laboratorio de Metabolismo Nutricio´n y Hormonas, Instituto de Investigacio´n Sanitaria-Fundacio´n Jime´nez Dı´az, Spain, 5FUNDACION JIMENEZ DIAZ, Spain Disclosures: Sergio Portal, None

222

MO0008

Community-dwelling Female Fallers Have Lower Leg Muscle Density, and Similar Forearm Muscle Density and Distal Radius Bone Parameters Relative to Non-fallers: Evidence from the Saskatoon CaMos Cohort Andrew Frank*1, Jonathan Farthing2, Philip Chilibeck2, W.P. Olszynski3, Saija Kontulainen4. 1The University of Saskatchewan, Canada, 2College of Kinesiology, University of Saskatchewan, Canada, 3Midtown Medical Center (#103), Canada, 4 University of Saskatchewan, Canada Disclosures: Andrew Frank, None

MO0009

Development of an Immunoassay for the Quantitative Determination of Myostatin (GDF-8) Karl Florian Wintgens*, Corinna Berger, Stanka Stoeva, Franz Paul Armbruster. Immundiagnostik AG, Germany Disclosures: Karl Florian Wintgens, Immundiagnostik AG, 3

MO0010

Forearm Muscle and Cortical Bone Predict Fracture Load Jenny Zhao*1, Ruchun Dai1, Zhehao Dai1, Jon Jacobson1, Harry Genant2, Peter Augat3, Yebin Jiang1. 1Osteoporosis & Arthritis Lab, University of Michigan, USA, 2University of California, USA, 3Biomechanics Research Laboratory, Germany Disclosures: Jenny Zhao, None

MO0011

pQCT Measures of Bone and Muscle Are Independently Associated With Falls in Women – A Principal Components Analysis of Morphometric Measures Andy Kin On Wong*1, Aakash Bhargava1, Karen Beattie1, Christopher Gordon1, Laura Pickard1, Colin Webber2, Alexandra Papaioannou 2, Jonathan Adachi3. 1McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3St. Joseph’s Hospital, Canada Disclosures: Andy Kin On Wong, None

MO0012

Retest Reliability of Muscle Function Testing in Older Adults Bjoern Buehring*1, Ellen Fidler 1, Diane Krueger1, Neil Binkley2. 1University of Wisconsin, Madison, USA, 2University of Wisconsin, USA Disclosures: Bjoern Buehring, None

MO0013

The Association Between Serum 25-Hydroxyvitamin D and Obesity and Sarcopenia in Elderly Men Vidmantas Alekna*, Asta Mastaviciute, Marija Tamulaitiene. Vilnius University, Lithuania Disclosures: Vidmantas Alekna, Amgen, 8; Amgen, 5; Amgen, 2; Novartis, 8; GSK, 8

AGING AND MUSCLE/BONE INTERACTIONS: REHABILITATION AND EXERCISE MO0014

Bone Micro-Architecture, Muscle Strength, and Undercarboxylated Osteocalcin in MiddleAged Men Itamar Levinger* 1, Roger Zebaze2, Ali Ghasem-Zadeh2, George Jerums3, David Hare3, Steve Selig4, Ego Seeman2. 1Victoria University, Australia, 2Austin Health, University of Melbourne, Australia, 3Austin Health, Australia, 4Deakin University, Australia

MO0015

Reambulation After Disuse Causes Differential Age-Dependent Responses in Bone Strength and Bone Formation in Trabecular and Cortical Bone Tristan Fowler*1, Thomas Williams1, Nisreen Akel1, William Hogue1, Frances Swain1, Esther Dupont-Versteegden2, Larry Suva1, Dana Gaddy1. 1University of Arkansas for Medical Sciences, USA, 2University of Kentucky, USA Disclosures: Tristan Fowler, None

MO0016

Yoga Spinal Flexion Positions and Vertebral Compression Fracture in Osteopenia of Spine Mehrsheed Sinaki*1, Bart L Clarke1, Elisabeth Preisinger 2, Vahab Fatourechi1. 1Mayo Clinic, USA, 2Univ Vienna, Austria Disclosures: Mehrsheed Sinaki, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: ASSESSMENT OF PEDIATRIC BONE DISEASE MO0017

Bone Densitometry Evaluations in Juvenile Dogs Rana Samadfam*1, Maria Adamo2, Aurore Varela1, Keith Robinson2, Susan Y. Smith1. 1 Charles River Laboratories, Canada, 2Charles River, Canada Disclosures: Rana Samadfam, None

223

Monday

Disclosures: Itamar Levinger, None

MO0018

In Vivo and Ex Vivo Measurements of Post Natal Skeletal Development in Rodents NonClinical Reproductive Toxicology and Pediatric Studies Aurore Varela*1, Maria Adamo2, Jacquelin Jolette3, Luc Chouinard4, Rana Samadfam1, Keith Robinson 2, Susan Y. Smith 1. 1Charles River Laboratories, Canada, 2Charles River, Canada, 3Charles River Laboratories, Preclinical Services Montreal, Canada, 4Charles River Laboratories, PCS Montreal, Canada Disclosures: Aurore Varela, None

MO0019

Increasing Incidence of Nutritional Rickets in Olmsted County, Minnesota, since 1970 Tom Thacher*1, Philip Fischer1, Peter Tebben2, Ravinder Singh1, Stephen Cha1, Barbara Yawn3. 1Mayo Clinic, USA, 2Mercy Health, USA, 3Olmsted Medical Center, USA Disclosures: Tom Thacher, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: BONE ACQUISITION MO0020

Age-Related Changes in Cortical Bone Geometry in the Human Tibial Diaphysis: A WholeBone Perspective Zachariah Hubbell*1, James Gosman1, Colin Shaw2, Timothy Ryan2. 1The Ohio State University, USA, 2Pennsylvania State University, USA Disclosures: Zachariah Hubbell, None

MO0021

A Comparison of Trabecular Bone Microstructure at the Distal Radius and Distal Tibia Between Healthy Weight and Overweight Adolescents: An HR-pQCT Study Christa Hoy* 1, Lindsay Nettlefold1, Sarah Moore1, SoJung Kim1, Meghan Donaldson2, Heather Macdonald 1, Heather McKay1. 1University of British Columbia, Canada, 2San Francisco Coordinating Center, USA Disclosures: Christa Hoy, None

MO0022

Accumulation of Bone Marrow Adipose Tissue in Childhood May Adversely Affect Skeletal Strength Krista Casazza* 1, Lynae Hanks1, Harry Hu2. 1UAB, USA, 2USC, USA Disclosures: Krista Casazza, None

MO0023

Bone Biomarkers and Mineral Biochemistries in Early Pubertal Black and White Adolescent Boys and Girls Kathleen Hill* 1, Berdine Martin2, Emma Laing3, Stuart Warden4, George McCabe2, Richard Lewis3, Connie Weaver2, Munro Peacock5. 1Indiana University School of Medicine, USA, 2Purdue University, USA, 3The University of Georgia, USA, 4Indiana University, USA, 5Indiana University Medical Center, USA Disclosures: Kathleen Hill, None

MO0024

Influence of Bone Age and Diet-induced Weight Loss on Bone Mineral Density in Prepubertal Obese Children Guillermo Martinez Diaz-Guerra*1, Gabriel Martos2, Sonsoles Guadalix3, Jesu´s Argente2, Federico Hawkins4. 1University Hospital 12 Octubre, Spain, 2Hospital Infantil Universitario Nin˜o Jesu´s, Spain, 3University Hospital 12 de Octubre, Spain, 4Hospital Universitario, Spain Disclosures: Guillermo Martinez Diaz-Guerra, None

MO0025

Insulin Inhibits Cortical Bone Development Independently of Body Composition: Findings From a Cross Sectional Analysis of pQCT Parameters in Adolescents. Adrian Sayers*1, Debbie Lawlor1, Naveed Sattar2, J.H. Tobias3. 1University of Bristol, United Kingdom, 2University of Glasgow, United Kingdom, 3Avon Orthopaedic Centre, United Kingdom Disclosures: Adrian Sayers, None

MO0026

Skeletal Muscle Fat Content is Inversely Associated with Bone Strength in Young Girls Joshua Farr*1, Janet Funk2, Zhao Chen3, Jeffrey Lisse4, Robert Blew1, Vinson Lee1, Monica Laudermilk1, Timothy Lohman4, Scott Going4. 1The University of Arizona, USA, 2 University of Arizona Health Sciences Center, USA, 3University of Arizona College of Public Health, USA, 4University of Arizona, USA Disclosures: Joshua Farr, None

224

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: BONE LOSS MO0027

Lumbar Bone Mineral Density (BMD) in Children with Duchenne Muscular Dystrophy Treated with Corticosteroids Cristina Tau*1, Gisela Viterbo2, Soledad Monges3, Juliana Castagneto4. 1Metabolismo Ca´lcico, Endocrinologı´a, Hospital de Pediatria Garrahan, Argentina, 2Endocrinologia, Hospital de Pediatria Garrahan, Argentina, 3Neurologia, Hospital de Pediatria Garrahan, Argentina, 4Metabolismo Ca´lcico, Endocrinologia, Hospital de Pediatria Garrahan, Argentina Disclosures: Cristina Tau, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: PATHOPHYSIOLOGY OF PEDIATRIC BONE DISEASE MO0028

Idiopathic Infantile Hypercalcemia Stepan Kutilek*1, Sylva Skalova2, Josef Gut3, Milan Bayer2. 1Pardubice Hospital; Faculty of Health Studies; University of Pardubice, Czech Republic, 2Department of Paediatrics in Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic, 3Dept. of Pediatrics, Ceska Lipa Hospital, Czech Republic Disclosures: Stepan Kutilek, None

BONE ACQUISITION AND PEDIATRIC BONE DISEASE: TREATMENT OF PEDIATRIC BONE DISEASE MO0029

Mechanical-Tactile Stimulation Increases Tibial Bone Strength in Preterm Infants Laurie Moyer-Mileur 1, Hillarie Slater1, Kimberly Neff 1, Joanna Beachy1, Sandra Smith1, Chelsea Evans2, Brett Barrett1, Shannon Haley*3. 1University of Utah, USA, 2Universtiy of Utah, USA, 3University of Utah School of Medicine, USA Disclosures: Shannon Haley, None

MO0030

Transmission of a Floor-based Vibration Stimulus Across the Tibia and Femur in Children with Osteogenesis Imperfecta Christopher Modlesky* 1, Marcus Spera1, Kurt Manal1, Brianne Mulrooney 1, Lauren Davey2, Erica Hartman1, Michael Bober2. 1University of Delaware, USA, 2A.I. DuPont Hospital for Children, USA Disclosures: Christopher Modlesky, None

BONE BIOMECHANICS AND QUALITY: ASSESSMENT OF BONE QUALITY AND STRENGTH MO0031

Active Shape Modelling of Bilateral Knee Osteoarthritis in the Osteoarthritis Initiative Jennifer Gregory, Richard Aspden, David Reid, Rebecca J Barr, Fiona Saunders*. University of Aberdeen, United Kingdom Disclosures: Fiona Saunders, None

MO0032

Disclosures: Gurjit Mandair, None MO0033

Biomechanical Role of Collagen Cross-Links in Bone Strength: Finite Element Study Abdelwahed Barkaoui* 1, Ridha Hambli1, Awad Bettamer2. 1PRISME Institute, EA4229, University of Orleans, France, 2L’Universite´ d’Orle´ans, France Disclosures: Abdelwahed Barkaoui, None

MO0034

Bone Mineral Density (BMD) and Microarchitecture Assessment by Trabecular Bone Score (TBS) at the Spine in Patients with Rheumatoid Arthritis (RA) and Systemic Sclerosis (SSc) Euge´nie Koumakis*1, Emese Toth1, Marine Meunier1, Emilie Maury2, Andre´ Kahan1, Yannick Allanore1, Catherine Cormier3. 1Rheumatology Department A, Cochin Hospital, APHP, Paris Descartes University, France, 2Service De Rhumatologie A, AP-HP Groupe Hospitalier Cochin - Saint Vincent De Pa, France, 3AP-HP Groupe Hospitalier Cochin, France Disclosures: Euge´nie Koumakis, None

MO0035

Changes in Osteocyte Density in Postmenopausal Women with Prodromal Bone Deterioration (PBD) in Femoral Shaft after Long Term Bisphosphonate Therapy D. Sudhaker Rao, Shijing Qiu*, Saroj Palnitkar. Henry Ford Hospital, USA Disclosures: Shijing Qiu, None

225

Monday

Are Raman Spectroscopic and MicroCT Compositional Measurements Commensurate? Gurjit Mandair*1, Jason P. Long2, Jessica Lopez 1, Steven A. Goldstein2, Michael D. Morris1. 1University of Michigan, Department of Chemistry, USA, 2University of Michigan, Orthopaedic Research Labs, USA

MO0036

Chinese Women Have Greater Cortical Bone Density at the Hip Compared to White Women Marcella Walker*1, Isra Saeed2, Donald McMahon 1, Julia Udesky1, George Liu3, Thomas Lang2, John Bilezikian4. 1Columbia University, USA, 2University of California, San Francisco, USA, 3New York Downtown Hospital, USA, 4Columbia University College of Physicians & Surgeons, USA Disclosures: Marcella Walker, None

MO0037

Differentiation of Treatment Effects of Odanacatib from Alendronate in Ovariectomized Rhesus Monkeys Using Voxel Based Morphometry of Quantitative Computed Tomography Images Sangeetha Somayajula*1, Seetha R. Kummari 2, Todd Bredbenner3, Belma Dogdas4, John Szumiloski 5, Mona L Purcell6, Paul McCracken7, DON WILLIAMS 8, Le Thi Duong7, Sherri L Motzel9, Antonio Cabal10. 1USA, 2Case Western Reserve University, USA, 3 Southwest Research Institute, USA, 4Informatics -IT, Merck Research Laboratories, USA, 5Biometrics Research, Merck Research Laboratories, USA, 6Imaging, Merck Research Laboratories, USA, 7Merck Research Laboratories, USA, 8MERCK, USA, 9Lab Animal Resources, Merck Research Laboratories, USA, 10Merck & Co., Inc., USA Disclosures: Sangeetha Somayajula, None

MO0038

Hip Fracture in Older Women: Association with the Femoral Strength as Assessed by Finite Element Analysis of Qct Scans Lang Yang*1, Will J M Udall2, Eugene V McCloskey2, Richard Eastell2. 1Univesity of Sheffield, United Kingdom, 2University of Sheffield, United Kingdom Disclosures: Lang Yang, None

MO0039

Insulin resistance, Diabetes, and Composite Indices of Femoral Neck Strength: Findings from The Hip Strength Across the Menopausal Transition Study Shinya Ishii*1, Jane Cauley2, Preethi Srikanthan 3, Carolyn Crandall3, Mei-Hua Huang4, Michelle Danielson 5, Gail Greendale3, Arun Karlamangla3. 1UCLA, VA, USA, 2University of Pittsburgh Graduate School of Public Health, USA, 3University of California, Los Angeles, USA, 4UCLA, USA, 5University of Pittsburgh, USA Disclosures: Shinya Ishii, None

MO0040

Measuring Apparent Trabecular Structure with the Stratec pQCT: A Comparison with HRpQCT Deena Lala*1, Angela Cheung2, Kayla Hummel1, Dean Inglis3, Christopher Gordon3, Lora Giangregorio 1. 1University of Waterloo, Canada, 2University Health Network, Canada, 3 McMaster University, Canada Disclosures: Deena Lala, None

MO0041

Morphometric Assessment of Vertebral Fracture Risk in Postmenopausal Women using Vertebral Shape Models and Discriminative Shape Alignment Alessandro Crimi1, Marco Loog2, Marleen de Bruijne3, Mads Nielsen4, Martin Lillholm*5. 1 Nordic Bioscience & University of Copenhagen, Denmark, 2Delft University of Technology, Netherlands, 3University Medical Center Rotterdam, Netherlands, 4University of Copenhagen, Denmark, 5Synarc Imaging Technologies, Denmark Disclosures: Martin Lillholm, CCBR Synarc, 2

MO0042

Nanoindentation Shows Significantly Increased E, H and Viscosity for Sclerotic Bone Healing Response, Corresponding well with Micro-CT and pQCT Results Xiuli Chen*1, Yong Hoow Chan2, Sungyun Park2, James Goh3, Shamal Das De3, Richie Soong4, Taeyong Lee1. 1National University of Singapore, Singapore, 2Division of Bioengineering, National University of Singapore, Singapore, 3Department of Orthopaedic Surgery, National University Hospital, Singapore, 4Department of Pathology, National University of Singapore, Singapore Disclosures: Xiuli Chen, None

MO0043

Physical Exercise Programs in a Female Rat Model: What Is the Most Osteogenic? Priscilla C. AVELINE*, Eric LESPESSAILLES, Claude-Laurent BENHAMOU, Gael Rochefort. INSERM U658, France Disclosures: Priscilla C. AVELINE, None

226

MO0044

Pre- and Post-Menopausal Differences in Bone Density, Microstructure, and Mechanical Competence in Chinese-American and Caucasian Women Xiaowei Liu*1, Marcella Walker2, Emily Stein1, Bin Zhou 2, Julia Udesky2, George Liu 3, Donald McMahon1, Elizabeth Shane1, John Bilezikian1, X Guo2. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University, USA, 3New York Downtown Hospital, USA Disclosures: Xiaowei Liu, None

MO0045

Pyridoxamine and Sorbinil Do Not Prevent Bone Mechanical and Tissue Deterioration in a Rat Model of Type 2 Diabetes Maxime Gallant*1, Kathleen Hill1, Benjamin Rowland1, Matthew Allen1, Richard G. Peterson2, David Burr1. 1Indiana University School of Medicine, USA, 2PreClinOmics Inc., USA Disclosures: Maxime Gallant, None

MO0046

Quantitative Bone Micro-Architecture in Young Adults Using Multi-Detector CT Imaging and Volumetric Topological Analysis – A Feasibility Study Punam K. Saha*, Yinxiao Liu, Cynthia Pauley, Trudy Burns, James Torner, Steven Levy. University of Iowa, USA Disclosures: Punam K. Saha, None

MO0047

Recent Hip Fracture Does Not Account for Polar and Radial Distribution of Cortical Density At Tibial Mid-Diaphysis Ari Heinonen*1, Timo Rantalainen2, Johanna Koskinen3, Marja Arkela-Kautiainen4, Mauri Kallinen4, Sarianna Sipila¨3. 1Department of Health Sciences, University of Jyva¨skyla¨, Fin, 2 Department of Mechanical Engineering, Lappeenranta University of Technology & Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyva¨skyla¨, Finland, 3Gerontology Research Centre, Department of Health Sciences, University of Jyva¨skyla¨, Finland, 4Central Finland Central Hospital, Finland Disclosures: Ari Heinonen, None

MO0048

Reference Point Indentation: A new paradigm for characterization of visco-elastic materials Alexander Proctor*, Davis Brimer. Active Life Scientific, Inc., USA Disclosures: Alexander Proctor, Active Life Scientific, Inc., 3

MO0049

Regional Variation in Cortical Microarchitecture of the Distal Radius and Tibia Galateia Kazakia*1, Gregory Bernstein 2, Miki Sode3, Andrew Burghardt1, Sharmila Majumdar1. 1University of California, San Francisco, USA, 2University of California, USA, 3University of California San Francisco & Berkeley, USA Disclosures: Galateia Kazakia, None

MO0050

Disclosures: Tetsuo Yano, Ajinomoto Pharmaceuticals, 3 MO0051

Skeletal Fragility and Hip Geometry: The Fracture Is "Behind the Angle". Monica Celi* 1, Irene Cerocchi2, Alessandro Scialdoni3, Luca Saturnino3, Umberto Tarantino 4. 1University of Rome Tor Vergata, Italy, 2Universita’ Di Roma Tor Vergata, Italy, 3University of Tor Vergata, Italy, 4Azienda Ospedaliera PTV, Italy Disclosures: Monica Celi, None

MO0052

Statistical Power in Measures of Microscopic Tissue Damage in Cancellous Bone Katherine Ehlert*1, Ralph G. O’Brien2, Christopher Hernandez 1. 1Cornell University, USA, 2Case Western Reserve Univerisity, USA Disclosures: Katherine Ehlert, None

MO0053

The Correlation Between Bone Mineral Density Values With Insertion Torque of Pedicle Screws In Posterior Lumbar Pedicle Screw Fixation Jae Hyup Lee*1, Young-Ho Shin 2, Ji-Ho Lee2, Jae Woo Park2, Hye Soo Lee 2. 1Seoul National University, College of Medicine, South Korea, 21Department of Orthopedic Surgery, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, South Korea Disclosures: Jae Hyup Lee, None

227

Monday

Risedronate Improves Bone Architecture and Strength Faster Than Alendronate in Ovariectomized Rats on a Low Calcium Diet. Tetsuo Yano*1, Mei Yamada1, Tomoyuki Konda2, Makoto Shiozaki1, Daisuke Inoue3. 1 Ajinomoto Pharmaceuticals Co., LTD, Japan, 2Ajinomoto Pharmaceuticals Co., LTD., Japan, 3Teikyo University Chiba Medical Center, Japan

MO0054

The Effect of Advanced Glycation Endproducts on Cortical Bone Mechanical Properties Sibi Sutty1, Christopher Tranquada2, Marc Grynpas1, Thomas Willett*3. 1Samuel Lunenfeld Research Institute, Canada, 2University of Toronto, Canada, 3Mount Sinai Hospital, Canada Disclosures: Thomas Willett, None

MO0055

Validation of a Novel Microindenter for Bone Material Strength Measurement Robert Guerri Fernandez*1, Adolfo Diez-Perez2, Xavier Nogues3, Daniel Prietoalhambra3, Leonardo Mellibovsky 4, Daniel Bridges5, Connor Randall6, Paul Hansma7. 1 Fundacio IMIM, Spain, 2Autonomous University of Barcelona, Spain, 3Institut Municipal D’Investigacio´ Me`dica, Spain, 4Internal Medicine / Infectious Diseases. Hospital del Mar. IMIM, Spain, 5University of California Santa Barbara, USA, 6UCSB, USA, 7University of California, Santa Barbara, USA Disclosures: Robert Guerri Fernandez, None

MO0056

Volumetric Bone Mineral Density Estimation using a 3D Reconstruction Method from Dualenergy X-ray Absorptiometry Tristan Whitmarsh 1, Ludovic Humbert 2, Luis Del Rio*3, Alejandro Frangi4. 1Universitat Pompeu Fabra, Spain, 2Ph, Spain, 3Cetir Centre Medical, Spain, 4PhD, Spain Disclosures: Luis Del Rio, None

BONE BIOMECHANICS AND QUALITY: CHANGES IN BONE QUALITY IN UNTREATED AND TREATED OSTEOPOROSIS MO0057

Changes in the 3D Osteocyte Lacunar Network Induced by Estrogen Withdrawal and Pharmaceutical Treatment of Osteoporosis as Detected by Synchrotron Micro-CT Steven Tommasini*1, Andrea Trinward1, Alvin Acerbo2, Lisa Miller3, Stefan Judex1. 1 Stony Brook University, USA, 2Brookhaven National Laboratody, USA, 3Brookhaven National Laboratory, USA Disclosures: Steven Tommasini, None

MO0058

Gradients in Mineralization and Nanomechanical Properties Across Trabeculae are Altered with Zolendronate Treatment in an Ovine Model of Osteoporosis Jayme Burket*1, Jennifer MacLeay 2, Shefford Baker1, Adele Boskey3, Marjolein Van Der Meulen1. 1Cornell University, USA, 2Hill’s Pet Nutrition, Inc., USA, 3Hospital For Special Surgery, USA Disclosures: Jayme Burket, None

MO0059

Mechanical Property and Tissue Mineral Density Differences Among Severely Suppressed Bone Turnover (SSBT) Patients, Osteoporotic Patients, and Normal Subjects Crystal Tjhia* 1, Clarita Odvina2, Sudhaker Rao3, Susan Stover4, Xiang Wang4, David Fyhrie4. 1University of California, Davis, USA, 2University of Texas Southwestern Medical Center, Dallas, USA, 3Henry Ford Hospital, USA, 4University of California Davis, USA Disclosures: Crystal Tjhia, None

MO0060

Prediction of Mechanical Bone Strength From In Vivo Bone Density And Biomarkers In A Rat Experiment - An Individual Model Using Automatic Learning Joseph Zarka*1, Eric Lespessailles 2, Su Hua Leow 1, ZAHRA ACHIOU3, Claude Laurent Benhamou 4. 1JZ SARL, France, 2Centre Hospitalier Regional, France, 3INSERM, France, 4 INSERM Orle´ans-France, France Disclosures: Joseph Zarka, None

MO0061

The Decrease in Cortical Bone Volumetric Mineral Density Induced by Teriparatide in Postmenopausal Osteoporotic Women is Associated With an Increase in Cortical Porosity as Assessed by High Resolution Peripheral Computerized Tomography (HR-pQCT) Cesar Bogado*1, Fernando Silveira1, David Dempster2, Hua Zhou3, Urszula Masiukiewicz4, Cecilia Fosser4, Jose Ruben Zanchetta1. 1Instituto de Investigaciones Metabolicas (IDIM), Argentina, 2Columbia University, USA, 3Helen Hayes Hospital, USA, 4Pfizer, Inc., USA Disclosures: Cesar Bogado, None

228

BONE BIOMECHANICS AND QUALITY: DISUSE OSTEOPOROSIS MO0062

Integrated Finite Element Modeling of Upper Femur Behavior With Ageing: From Cellular Activities Toward Fracture Ridha Hambli*1, Abdelwahed Barkaoui2, Romain Rieger1, Eric Lespessailles3, Claude Laurent Benhamou 4, Awad Bettamer5. 1PRISME INSTITUTE, France, 2PRISME Institute, EA4229, University of Orleans, France, 3Centre Hospitalier Regional, France, 4 INSERM Orle´ans-France, France, 5L’Universite´ d’Orle´ans, France Disclosures: Ridha Hambli, None

MO0063

Positive Association Between Circulating Sclerostin and Bone Mass in Chronic Spinal Cord Injury: Evidence Against Sclerostin as a Target to Treat Chronic Disuse Osteoporosis Leslie Morse*1, Supreetha Sudhakar2, Valery Danilack3, Carlos Tun4, Antonio Lazzari5, David Gagnon6, Eric Garshick7, Ricardo Battaglino8. 1Department of Physical Medicine & Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, USA, 2 Spaulding Rehabilitation Hospital, USA, 3Programs in Research at VA Boston, USA, 4 Rehabilitation Medicine Service, USA, 5Primary Care Section, VA Boston Healthcare System & Boston University School of Medicine, USA, 6VA Cooperative Studies Program, VA Boston Healthcare System, Department of Biostatistics, Boston University School of Public Health, USA, 7Pulmonary & Critical Care Medicine Section, Medical Service, VA Boston Healthcare System, Channing Laboratory, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, USA, 8The Forsyth Institute, USA Disclosures: Leslie Morse, None

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING CELLULAR AND MOLECULAR EFFECTS MO0064

Extracellular High Glucose Levels Modulate Bone Cell Mechanotransduction Mia Thi*, David C. Spray, Sylvia O. Suadicani. Albert Einstein College of Medicine, USA Disclosures: Mia Thi, None

MO0065

Fluid Shear Modulates COX2 mRNA Expression but not Mineralization during Oscillatory Motions Gunes Uzer*1, Sarah Manske1, Ete Meilin Chan1, Yi-Xian Qin2, Clinton Rubin2, Stefan Judex1. 1Stony Brook University, USA, 2State University of New York at Stony Brook, USA Disclosures: Gunes Uzer, None

Withdrawn

MO0067

Microscale Fluid-Flow Analysis in Osteocyte Canaliculi Using High-Resolution Image-Based Models Hiroshi Kamioka*1, Yoshitaka Kameo2, Yuichi Imai3, Astrid Bakker4, Rommel Bacabac5, Takashi Yamashiro3, Taiji Adachi6, Jenneke Klein-Nulend 7. 1Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sc, Japan, 2Department of Mechanical Engineering, Graduate School of Engineering, Osaka Prefecture University, Japan, 3Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, & Pharmaceutical Sciences, Japan, 4Department of Oral Cell Biology, ACTAUniversity of Amsterdam & VU University Amsterdam, Research Institute MOVE, Netherlands, 5Medical Biophysics group, University of San Carlos, Philippines, 6 Department of Biomechanics, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Japan, 7ACTA-VU University Amsterdam, Dept Oral Cell Biology (Rm # 11N-63), The Netherlands Disclosures: Hiroshi Kamioka, None

MO0068

Molecular Factors Involved in the Early Response of Bone and Skeletal Muscle to Mechanical Unloading Maria Squire*1, Jason Stankiewicz 2, Melissa Monaghan3, Anil Dhundale 4, Stefan Judex5. 1 Department of Biology, The University of Scranton, USA, 2Biochemistry Program, The University of Scranton, USA, 3OSI Pharmaceuticals, LLC, USA, 4LIHTI & SBU Business Incubators, Stony Brook University, USA, 5Biomedical Engineering Department, Stony Brook University, USA Disclosures: Maria Squire, None

229

Monday

MO0066

MO0069

The Effect of Vibratory Forces on the Rate of the Tooth Movement in Rats Zana Kalajzic* 1, Elizabeth Blake1, Achint Utreja1, Manshan Xu1, Jing Chen1, Flavio Uribe1, Ravindra Nanda1, Douglas Adams1, Sunil Wadhwa2. 1University of Connecticut Health Center, USA, 2University of Connecticut, USA Disclosures: Zana Kalajzic, None

MO0070

TNFa Partly Controls Fluid Pressure Induced Osteolysis Anna Fahlgren*1, Denis Nam1, Goran Andersson 2. 1Hospital for Special Surgery, USA, 2 Karolinska Institute, Sweden Disclosures: Anna Fahlgren, None

BONE BIOMECHANICS AND QUALITY: MECHANICAL LOADING EFFECTS IN HUMANS AND INTACT ANIMALS MO0071

Bone Geometry and Strength is Preserved in Adults Following Bariatric Surgery Lesley Scibora*1, Sayeed Ikramuddin1, Henry Buchwald1, Thomas Beck2, Moira Petit1. 1 University of Minnesota, USA, 2Quantum Medical Metrics, LLC, USA Disclosures: Lesley Scibora, None

MO0072

Effect of Carbohydrate Feeding on the Bone Metabolic Response to Exhaustive Running Craig Sale* 1, Julie Greeves2, Thomas Jones3, Ian Varley1, Ruth Hobson1, John Dutton4, William Fraser5. 1Nottingham Trent University, United Kingdom, 2HQ Army Recruiting & Training Division, United Kingdom, 3Northumbria University, United Kingdom, 4 University of Liverpool, United Kingdom, 5University of East Anglia, United Kingdom Disclosures: Craig Sale, None

MO0073

Heterogeneity In Mechanosensitivity Among Canadian Postmenopausal Women With and Without Fractures Celeste Hamilton*1, Thomas Beck2, Alia Khaled3, Sophie Jamal4, Jonathan Adachi5, Jacques Brown6, Kenneth S. Davison7. 1Women’s College Hospital/University of Toronto, Canada, 2Quantum Medical Metrics, LLC, USA, 3Department of Electrical & Computer Engineering, Johns Hopkins University, USA, 4The University of Toronto, Canada, 5St. Joseph’s Hospital, Canada, 6Laval University, Canada, 7Department of Medicine, Laval University, Canada Disclosures: Celeste Hamilton, None

MO0074

Increased Microcracks and Nanoindentation Modulus in the Subchondral Region of the Femoral Head Following Ischemic Necrosis Olumide Aruwajoye*1, Mihir Patel2, Matthew Allen3, Pranesh Aswath2, Harry Kim4. 1 Texas Scottish Rite Hospital, USA, 2University of Texas at Arlington, USA, 3Indiana University School of Medicine, USA, 4Scottish Rite Hospital for Children, USA Disclosures: Olumide Aruwajoye, None

MO0075

Low Intensity Pulsed Ultrasound as Targeted Therapy towards Bone Loss Sardar Uddin*1, Yi-Xian Qin2. 1Stony Brook University, USA, 2State University of New York at Stony Brook, USA Disclosures: Sardar Uddin, None

MO0076

Short Term Physical Activity May Induce Changes In Bone Density And Geometry Even After Bone Maturation In Talented Female Athletes Beatrice FERRY*1, Eric Lespessailles2, Gaele Ducher3, Martine DUCLOS4, Pierre ROCHCONGAR5, Geraldine NAUGHTON 6, Daniel Courteix7. 1Clermont Universite´, Universite´ Blaise Pascal, EA 3533, Laboratoire de Biologie des Activite´s Physiques et Sportives, BP 10448, F-63000; Universite´ de Limoges, Faculte´ des Sciences et Techniques, De´partement STAPS, F-87060 LIMOGES, France, 2Centre Hospitalier Regional, France, 3 Penn State University, USA, 4Service de Me´decine du Sport et des Explorations Fonctionnelles, France, 5Unite´ de biologie et me´decine du sport, CHU Pontchaillou, France, 6Centre of Physical Activity Across the Lifespan Australian Catholic University, Australia, 7Universite Clermont Ferrand Laboratoire De Biologie Des APS, France Disclosures: Beatrice FERRY, None

230

MO0077

b-Adrenergic Receptor Antagonist Suppresses Occlusal Force Unloading-Induced Alveolar Bone Loss in Rats Yasuhiro Shimizu*1, Jun Hosomichi 2, Sawa Kaneko1, Takashi Ono1. 1Orthodontic Science, Department of Orofacial Development & Function, Division of Oral Health Science, Graduate School, Tokyo Medical & Dental University, Japan, 2Department of Orthodontics & Pediatric Dentistry, School of Dentistry, University of Michigan, Orthodontic Science, Department of Orofacial Development & Function, Division of Oral Health Science, Graduate School, Tokyo Medical & Dental University, USA Disclosures: Yasuhiro Shimizu, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS TECHNIQUES MO0078

Collagen Enzymatic Cross-links Deficiency and Bone Quality Delphine Farlay*1, Marie-Eve Duclos2, Evelyne Gineyts 3, Cindy Bertholon 4, Ste´phanie Viguet-Carrin4, Thierry Roger5, Daniel Hartmann6, Roland Chapurlat7, Helene Follet8, Georges Boivin8. 1INSERM UMR1033; Universite´ de Lyon, France, 2Universite´ de Lyon, Vetagrosup, France, 3Universite´ De Lyon, France, 4INSERM, UMR1033; Universite´ de Lyon, France, 5VetAgroSup, France, 6Universite´ de Lyon, France, 7E. Herriot Hospital, France, 8INSERM, UMR 1033; Universite de Lyon, France Disclosures: Delphine Farlay, None

MO0079

Polarization Control of Raman Spectroscopy Optimizes Measures of Bone Quality Alexander Makowski*1, Chetan Patil1, Lacey Gorochow1, Anita Mahadevan-Jansen1, Jeffry Nyman2. 1Vanderbilt University, USA, 2Vanderbilt University Medical Center, USA Disclosures: Alexander Makowski, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: ANALYSIS: CALCIFICATION MO0080

Calcified Cartilage in Mature Rat Cortical Bone Fiona Linnea Bach-Gansmo 1, Jesper Thomsen2, Annemarie Bru¨el2, Henrik Birkedal*1. 1 Aarhus University, Denmark, 2University of Aarhus, Denmark Disclosures: Henrik Birkedal, None

MO0081

Thermodynamic Properties and Characterization of Proteoliposomes Rich in Microdomains Carrying Alkaline Phosphatase Mayte Bolean*1, Ana Maria Sima˜o 1, Bruno Favarin1, Jose Luis Millan2, Pietro Ciancaglini 3. 1Department of Chemistry, FFCLRP-USP, Brazil, 2Sanford-Burnham Medical Research Institute, USA, 3FFCLRP-USP, Brazil Disclosures: Mayte Bolean, None

MO0082

Disclosures: Louis Gerstenfeld, Pervasis Therapeutics, 2

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: CARTILAGE AND CHONDROCYTES MO0083

Pknox2 Is Identified as a Regulator for Ulna and Deltoid Tuberosity Formation During Limb Development Wenrong Zhou*1, Zhu Huang2, Haixia Zhao2, Jingjing Cao3, Wan Yong2, Jun Yang4, Gang Ma2, Rujiang Zhou3, Xizhi Guo2. 1Shanghai JiaoTong University, Peoples Republic of China, 2 Shanghai Jiao Tong University, Peoples Republic of China, 3Bio-X Center, Shanghai Jiao Tong University, China, 4Shanghai Jiao Tong University, China Disclosures: Wenrong Zhou, None

MO0084

Activation of TGF-b Signaling Regulates Joint and Tendon Marker Expressions in Isolated Joint Developing TGF-b Type II Receptor Expressing Cells Tieshi Li*1, Lara Longobardi1, Froilan Granero-Molto1, Timothy Myers2, Ying Li 1, Douglas Mortlock3, Anna Spagnoli1. 1University of North Carolina at Chapel Hill, USA, 2 University of North Carolina, USA, 3Vanderbilt University Medical Center, USA Disclosures: Tieshi Li, None

231

Monday

Vascular Endothelial Cells Produce Factors that Promote Osteogenic Differentiation of MSCs but Inhibit Mineral Deposition and Terminal Osteocyte Differentiation Jennifer Fitch1, James Birkhead 2, Elle Nugent2, Louis Gerstenfeld*1. 1Boston University School of Medicine, USA, 2Pervasis Therapeutics, USA

MO0085

Delayed Bone Fracture Healing In Mice Due to Tamoxifen-induced Knockout of IGF1R Gene In Chondrocyte Zhiqiang Cheng*1, Hanson Ho2, Fuqing Song2, Alfred LI 3, Christian Santa Maria2, Yongmei Wang4, Michael You3, Chialing Tu 3, Daniel Bikle 5, Wenhan Chang1. 1University of California, San Francisco, USA, 2VAMC, UCSF, USA, 3VAMC,UCSF, USA, 4 Endocrine Unit, University of California, San Francisco/VA Medical Center, USA, 5 Endocrine Research Unit, Division of Endocrinology UCSF, USA Disclosures: Zhiqiang Cheng, None

MO0086

Developing GFP Reporters for Assessing Lineage Progression Within Articular and Fibroarticular Tissues Sumit Yadav*, Xi Jiang, Jianping Huang, Peter Maye, Ivo Kalajzic, David Rowe. University of Connecticut Health Center, USA Disclosures: Sumit Yadav, None

MO0087

Essential Role of the Runx2-Cbf-b Transcription Complex for Endochondral Bone Formation Kyung-eun Lim1, Jung-eun Kim2, Ichiro Taniuchi3, Na-rae Park*1, Suk-Chul Bae 4, JeYong Choi5. 1Department of Biochemistry & Cell Biology, Skeletal Diseases Genome Research Center, School of Medicine, WCU Program, Cell & Matrix Research Institute, Kyungpook National University, South Korea, 2Depat. of Molecular Medicine, Kyungpook National University School of Medicine, South Korea, 3Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy & Immunology, Japan, 4 Department of Biochemistry, School of Medicine, Institute for Tumor Research, Chungbuk National University, South Korea, 5Kyungpook National University, School of Medicine, South Korea Disclosures: Na-rae Park, None

MO0088

Expression of Ift88, a Cilia Component Gene, is Under Temporal Regulation Along with the Differentiation of Chondrocytic Cell Line ATDC5 Makiri Kawasaki* 1, Tetsuya Nakamoto1, Takuya Notomi2, Tadayoshi Hayata3, Yoichi Ezura4, Masaki Noda1. 1Tokyo Medical & Dental University, Japan, 2GCOE, Tokyo Medical & Dental University, Japan, 3Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 4Tokyo Medical & Dental University, Medical Research Insititute, Japan Disclosures: Makiri Kawasaki, None

MO0089

Neurofibromin Is Required for Normal Endochondral Ossification Koichiro Ono* 1, Weixi Wang2, Jean Ndong3, Heather Eleanor3, Xiangli Yang2, Florent Elefteriou2. 1Center for Bone Biology, USA, 2Vanderbilt University, USA, 3Vanderbilt University Medical Center, USA Disclosures: Koichiro Ono, None

MO0090

Sirt6 Regulates Chondrocyte Proliferation and Differentiation during Endochondral Ossification Jinying Piao*1, Hiroki Ochi2, Kunikazu Tsuji 3, Daisuke Koga 4, Atsushi Okawa4, Sadao Morita1, Shu Takeda2, Yoshinori Asou 4. 1Department of Rehabilitation Medicine, Graduate School, Tokyo Medical & Dental University, Japan, 2Section of Nephrology, Endocrinology & Metabolism, Department of Internal Medicine, School of Medicine, Keio University., Japan, 3Section of Orthopedic Surgery, Division of Bio-Matrix, Graduate School, Tokyo Medical & Dental University, Japan, 4Department of Orthopaedics Surgery, Tokyo Medical & Dental University, Japan Disclosures: Jinying Piao, None

MO0091

TGF-b-induced SnoN Prevents BMP Signaling and Hypertrophic Conversion of Chondrocytes Ichiro Kawamura*, Yasuhiro Ishidou, Katsuyuki Imamura, Masahiro Yokouchi, Setsuro Komiya, Shingo Maeda. Graduate School of Medical & Dental Sciences, Kagoshima University, Japan Disclosures: Ichiro Kawamura, None

MO0092

The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification Xianrong Zhang*1, Valerie Siclari2, Shenghui Lan 3, Ji Zhu1, Frank Beier4, Ling Qin2. 1 University of Pennsylvania, School of Medicine, USA, 2University of Pennsylvania, USA, 3 Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, China, 4University of Western Ontario, Canada Disclosures: Xianrong Zhang, None

232

MO0093

The Differentiation Capacity of the Mesenchymal Stem Cells into Intervertebral Disc Under the Hypoxia Condition Hwan-Mo Lee1, Seong-Hwang Moon2, Young-Mi Kang*1. 1Yonsei university, South Korea, 2Yonsei University College of Medicine, South Korea Disclosures: Young-Mi Kang, None

MO0094

Understanding the Mechanisms of Radius and Ulna Deformation in Neonatal Chkb Mutant Mice Zhuo (Bill) Li*. University of Alberta, Canada Disclosures: Zhuo (Bill) Li, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENE IDENTIFICATION AND EXPRESSION MO0095

Annexin a5 Expression Regulates Periodontal Tissue and Cementum Formation Akemi Shimada* 1, Koichiro Komatsu1, Kazuhisa Nakashima 1, Norio Amizuka2, Bent Brachvogel 3, Akira Nifuji1. 1Tsurumi University School of Dental Medicine, Japan, 2 Hokkaido University School of Dentistry, Japan, 3Universitat Zu Koln, Germany Disclosures: Akemi Shimada, None

MO0096

Novel Genes Critical for Bone Formation Yunxia (Yesha) Lundberg*1, Mohammed Akhter2, Liping Yang1, Hui Zhang1, Hua Yang1, Xing Zhao1, Yinfang Xu1, Yan Zhang1. 1Boys Town National Research Hospital, USA, 2 Creighton University, USA Disclosures: Yunxia (Yesha) Lundberg, None

MO0097

Pax9, a Transcription Factor That Is Expressed in Ligament Cells Derived From Ligamentum Flavum of Patients with Lumbar Spinal Canal Stenosis. Ken Watanabe*, Yoshihito Sakai, Shumpei Niida, Atsushi Harada. National Center for Geriatrics & Gerontology, Japan Disclosures: Ken Watanabe, None

MO0098

Phenotypic Analysis of Transgenic Mice Overexpressing Msx1 in Oral Bones Ibtisam Senussi*1, Ariane Berdal2, Sylvie Babajko3. 1Inserm U872, France, 2University Paris-Diderot, France, 3INSERM, France Disclosures: Ibtisam Senussi, None

MO0099

Skeletal Phenotyping of Chibby Knockout Mice David Komatsu*1, Joshua J. Hinkle2, Mohanlall Narine2, Feng-Qian Li3, Ken-Ichi Takemaru3, Michael Hadjiargyrou4. 1Stony Brook University, Dept. of Orthopaedics, USA, 2 Stony Brook University, Dept. of Biomedical Engineering, USA, 3Stony Brook University, Dept. of Pharmacology, USA, 4State University of New York at Stony Brook, USA Disclosures: David Komatsu, None

MO0100

Disclosures: Dobrawa Napierala, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: GENERAL MO0101

Absence of P2X7 Nucleotide Receptors Leads to Abnormal Fat Distribution in Mice Kim Beaucage*, Andrew Xiao, Matthew Grol, David Holdsworth, Stephen Sims, Mark Darling, S. Jeffrey Dixon. The University of Western Ontario, Canada Disclosures: Kim Beaucage, None

MO0102

Alkaline pH Increases Phosphate Production by Proteoliposomes Carrying Alkaline Phosphatase and Nucleotide Pyrophosphatase/ Phosphodiesterase-1 Ana Maria Simao*1, Mayteˆ Bolean2, Jose Luis Millan3, Marc Hoylaerts4, Pietro Ciancaglini 2. 1University of Sao Paulo - USP, Brazil, 2FFCLRP-USP, Brazil, 3SanfordBurnham Medical Research Institute, USA, 4Center for Molecular & Vascular Biology, University of Leuven, Belgium Disclosures: Ana Maria Simao, None

233

Monday

Trps1 Plays Distinct Roles in the Development and Function of Mineralizing Tissues Dobrawa Napierala*1, Brian Dawson2, Terry Bertin 3, Chad Shaw3, Anne Poliard4, Odile Kellerman 5, Brendan Lee 6. 1University of Alabama at Birmingham, School of Dentistry, USA, 2Baylor College of Medicine, Howard Hughes Medical Institute, USA, 3Baylor College of Medicine, USA, 4Faculte´ de Chirurgie Dentaire, et UMR-S 747, Universite´ Paris Descartes, France, 5INSERM, Universite´ Rene´ Descartes, France, 6Baylor College of Medicine & Howard Hughes Medical Institute, USA

MO0103

Bone Regeneration Potential of Polypropylene Fumarate Scaffolds Coated with Osteoconductive Agents Theresa Hefferan*1, M. Brett Runge1, Mahrokh Dadsetan1, James Herrick1, Donna Jewison1, Glenda Evans2, Viviane Luangphakdy3, Kentaro Shinohara3, Hui Pan3, George Muschler 4, Michael Yaszemski1. 1Mayo Clinic College of Medicine, USA, 2Mayo Clinic, USA, 3Cleveland Clinic, USA, 4Cleveland Clinic Foundation, USA Disclosures: Theresa Hefferan, None

MO0104

CD59 - A Novel Role in Bone Homeostasis Anja Bloom*1, Carole Elford 1, Robert J van ’t Hof2, B Paul Morgan1, Bronwen AJ Evans1, Daniel Aeschlimann1, Anwen S Williams1. 1Cardiff University, United Kingdom, 2 University of Edinburgh, United Kingdom Disclosures: Anja Bloom, None

MO0105

Dental Pulp Cells Exhibit High Performance as a Biomaterial for Bone Formation Through Expression of Annexin A8. Yuko Nakamichi*1, Takahiro Hagihara1, Midori Nakamura 1, Asayo Imaoka2, Yoshimitsu Abiko2, Hiroshi Nakamura 1, Naoyuki Takahashi 1, Nobuyuki Udagawa 1. 1Matsumoto Dental University, Japan, 2Nihon University, Japan Disclosures: Yuko Nakamichi, None

MO0106

Effect of AMD3100 on MSC Mobilization and Bone Regeneration in the Mouse Margaret McNulty*, Kent W. Christopherson, Robin R. Frank, Amarjit Virdi, D. Rick Sumner. Rush University Medical Center, USA Disclosures: Margaret McNulty, Musculoskeletal Transplant Foundation, 2

MO0107

Loss of Prolyl-3-Hydroxylation at Position 986 of Type I Collagen in Transgenic Mice Has A Negative Effect on Bone Mass and Structure Ingo Grafe*1, Dustin Baldridge1, Erica Homan1, Terry Bertin 1, Yuqing Chen1, Mary-Ann Weis2, Dobrawa Napierala1, Tao Yang1, Brian Dawson1, Caressa Lietman1, Elda Munivez1, Shan Chen1, Monica Grover1, Ming-Ming Jiang1, David Eyre2, Brendan Lee1. 1 Department of Molecular & Human Genetics, Baylor College of Medicine, USA, 2 Department of Orthopaedics & Sports Medicine, University of Washington, USA Disclosures: Ingo Grafe, None

MO0108

Peripheral Nerve Regulation of Early Heterotopic Ossification Elizabeth Salisbury*, Eric Rodenberg, Corinne Sonnet, ZaWaunyka Lazard, John Hipp, Francis Gannon, Tegy Vadakkan, Mary Dickinson, Elizabeth Olmsted-Davis, Alan Davis. Baylor College of Medicine, USA Disclosures: Elizabeth Salisbury, None

MO0109

PHOSPHO1 Overexpression Promotes Extracellular Matrix Mineralization in Osteoblast Cultures. Carmen Huesa*1, Manisha Yadav2, Elaine Seawright 3, Tina Moreira4, Jose Luis Millan4, Colin Farquharson 5. 1Roslin instituteUniversity of Edinburgh, United Kingdom, 2 Burnham Institute for Medical Research, USA, 3Roslin Insitute, University of Edinburgh, United Kingdom, 4Sanford-Burnham Medical Research Institute, USA, 5Roslin Institute, University of Edinburgh, United Kingdom Disclosures: Carmen Huesa, None

MO0110

Sexual Dimorphisms in Bone Mineral Density in Sprague-Dawley Rats from 8 to 20 Weeks of Age Jason DeGuire*, Hope Weiler. McGill University, Canada Disclosures: Jason DeGuire, None

MO0111

Whitetail Deer Antlerogenic Progenitor Cells Show Robust Mineralization in a Murine Ossicle Growth Model Ethan Daley*1, Amy Koh-Paige 1, Laurie McCauley 2, Steven Goldstein3. 1University of Michigan, USA, 2University of Michigan, School of Dentistry, USA, 3University of Michigan Orthopedic Research Labs, USA Disclosures: Ethan Daley, None

234

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: MATRIX PROTEINS MO0112

DMP1 Does Not Function As A Co-transcriptional Factor Baozhi Yuan 1, Shuxian Lin*2, Zhengguo Cao3, ying liu3, Yongbo Lu4, Marc Drezner5, Jian Feng6, Qi Zhang2, Tian Gao3. 1University of Wisconsin, Madison, USA, 2Baylor college of dentistry, USA, 3Baylor College of Dentistry, Texas A&M Health Science Center, USA, 4 University of Missouri, Kansas City, USA, 5University of Wisconsin, USA, 6Texas A&M Health Science Center, USA Disclosures: Shuxian Lin, None

MO0113

Thrombospondin-2 Promotes Collagen Fiber Assembly and Stability in the Osteoblast-Derived Extracellular Matrix Andrea Alford*, Anita Reddy. University of Michigan, USA Disclosures: Andrea Alford, None

BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX: PROTEINASES MO0114

Conditional Loss of MT-MMP Activity in Perivascular Tissues Leads to Disruption of Skeletal Growth Joanne Shi*, Susan Yamada, Emily Purcell, Pamela Robey, Kenn Holmbeck. National Institute of Dental & Craniofacial Research, USA Disclosures: Joanne Shi, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: FGF23 AND OTHER PHOSPHATONINS MO0115

Chronic MAPK Inhibition in Hyp Mice Rescues Disordered Vitamin D Metabolism and Skeletal Mineralization Defect Martin Zhang1, Daniel Ranch2, Anthony Portale1, Farzana Perwad*3. 1University of California, San Francisco, USA, 2Univ. Texas Health Science Center, San Antonio, USA, 3 University of California San Francisco, USA Disclosures: Farzana Perwad, None

MO0116

Dietary Phosphate Intake Modulates Phenotype of a Mouse Model of Familial Tumoral Calcinosis Shoji Ichikawa*, Amie K. Gray, Anthony M. Austin, Leah R. Padgett, Michael Econs. Indiana University School of Medicine, USA Disclosures: Shoji Ichikawa, None

MO0117

Evaluation of a New Automated Chemiluminescence Immunossay for FGF23 Yuichiro Shimizu*, Seiji Fukumoto, Toshiro Fujita. University of Tokyo Hospital, Japan Disclosures: Yuichiro Shimizu, None

MO0118

Disclosures: Michael Wacker, None

CALCIOTROPIC AND PHOSPHOTROPIC HORMONES: PARATHYROID AND PARATHYROID HORMONE-RELATED PEPTIDE MO0119

Absence of the Mid-region, Nuclear Localization Sequence, and C-terminus of PTHrP Alters the Osteogenic, Adipogenic, Chondrogenic, and Myogenic Differentiation of Murine Bone Marrow Stromal Cells Blake Hildreth*, Krista M. Hernon, Brandlyn N. Marlow, John Leong, Thomas Rosol, Ramiro Toribio. The Ohio State University, USA Disclosures: Blake Hildreth, None

MO0120

Acute Decline in Serum Sclerostin in Response to PTH Infusion in Healthy Men Elaine Yu*1, Ruchit Kumbhani2, Erica Siwila-Sackman2, Benjamin Leder3. 1Massachusetts General Hospital, USA, 2MGH Endocrine Unit, USA, 3Massachusetts General Hospital, Harvard Medical School, USA Disclosures: Elaine Yu, None

235

Monday

Fibroblast Growth Factor 23 (FGF23) Alters Gene Expression of Isolated Cardiac Ventricular Muscle Michael Wacker*1, Vladimir Tchikrizov2, Jaimee Mannix2, Chad Touchberry2, Jason Stubbs3, Lynda Bonewald2. 1University of Missouri-Kansas City School of Medicine, USA, 2 University of Missouri - Kansas City, USA, 3University of Kansas Medical Center, USA

MO0121

Greater Increase in Urinary Calcium in Response to 1,25(OH)2D3 in Genetic Hypercalciuric Stone-Forming Rats than in Controls Kevin Frick*1, John Asplin2, Christopher Culbertson1, Daniel Asplin2, Nancy Krieger1, David Bushinsky1. 1University of Rochester, USA, 2Litholink Corporation, USA Disclosures: Kevin Frick, None

MO0122

High Prevalence of Vitamin D Deficiency Among Pregnant Women at Term and Their Neonates in Thessaloniki, Northern Greece Gkastaris Konstantinos, Karras Spiros, Papadopoulou Foteini*. Panagia General Hospital, Thessaloniki, Greece Disclosures: Papadopoulou Foteini, None

MO0123

Intermittent PTH Therapy is Anabolic in the Temporomandibular Joint in Young Growing Mice Yosuke Kamiya*1, Jing Chen1, Manshan Xu1, Achint Utreja1, Kyeong Lee 1, Hector Aguila1, Carol Pilbeam1, Sunil Wadhwa2. 1University of Connecticut Health Center, USA, 2 University of Connecticut, USA Disclosures: Yosuke Kamiya, None

MO0124

Parathyroid Hormone-Vitamin D Relationship is Mediated by Weight Status Lynae Hanks*1, Krista Casazza2, Ambika Ashraf1, Timothy Mark Beasley1, Jessica Alvarez1, Jose Fernandez1. 1University of Alabama at Birmingham, USA, 2UAB, USA Disclosures: Lynae Hanks, None

MO0125

Parathyroidectomy Improves Bone Geometry and Microarchitecture in Female Patients with Primary Hyperparathyroidism. A 1-year Prospective, Controlled Study using High Resolution Peripheral Quantitative Computed Tomography Stinus Hansen*1, Ellen M Hauge2, Jens Erik Beck Jensen3, Kim Brixen4. 1Dept. of Endocrinology, Odense University Hospital, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Denmark, 3Osteoporosis Research Clinic, Hvidovre University Hospital, Denmark, 4Institute of Clinical Research, University of Southern Denmark, Denmark Disclosures: Stinus Hansen, None

MO0126

Phospholipase C Signaling through the PTH/PTHrP Receptor Is Required for Serum Phosphate Homeostasis but not for Serum 1,25(OH)2D3 Jun Guo*1, Hiroko Segawa2, Lige Song1, Minlin Liu1, F. Richard Bringhurst 1, Ken-Ichi Miyamoto 3, Henry Kronenberg1, Harald Jueppner1. 1Massachusetts General Hospital, USA, 2University of Tokushima Graduate School, Japan, 3Tokushima University School of Medicine, Japan Disclosures: Jun Guo, None

MO0127

PTH Activates BMP Signaling by Inducing Endocytosis of BMP Extracellular Antagonists Bing Yu*1, Xiaoli Zhao2, Chaozhe Yang3, William Lu2, Mei Wan4, Xu Cao1. 1Johns Hopkins University, USA, 2Department of Orthopaedics & Traumatology, The University of Hong Kong, China, 3Department of Orthopaedic Surgery, The Johns Hopkins University, USA, 4Johns Hopkins University School of Medicine, USA Disclosures: Bing Yu, None

MO0128

Regulation of Renal Sodium-Dependent Phosphate Co-Transporters During Lipopolysaccharide-Induced Acute Inflammation Shoko Ikeda*1, Hironori Yamamoto1, Mina Kozai1, Masashi Masuda1, Sarasa Tanaka1, Otoki Nakahashi1, Hiroko Segawa2, Yutaka Taketani1, Ken-Ichi Miyamoto 2, Eiji Takeda1. 1Dept. Clinical Nutrition, University of Tokushima, Japan, 2Dept. Molecular Nutrition, University of Tokushima, Japan Disclosures: Shoko Ikeda, None

MO0129

The Immediate PTH Anabolic Action on Bone Marrow Mesenchymal Progenitor Cells Valerie Siclari*1, Ji Zhu2, Fei Liu 1, Abhishek Chandra1, Ling Qin1. 1University of Pennsylvania, USA, 2University of Pennsylvania, School of Medicine, USA Disclosures: Valerie Siclari, None

MO0130

Treatment of Non-healing Fractures with Parathyroid -hormone (1-34) Thomas Westphal1, Dirk Ganzer2, Kathrin Baessgen1, Guido Schroeder1, Hans-Christof Schober*3. 1Klinikum Su¨dstadt, Germany, 2Dietrich Bonhoeffer Klinikum, Germany, 3 Klinikum Su¨dstadt RostockKlinik Fu¨r Innere Medizin I, Germany Disclosures: Hans-Christof Schober, None

236

CANCER AND BONE: BREAST AND PROSTATE MO0131

Bone Loss in the B-ABLE Clinical Cohort of Women Completing Aromatase Inhibitor 2-year therapy after Tamoxifen: Patterns and Determinants Daniel Prieto-alhambra*1, Sonia Servitja2, Laia Garrigos2, Elisa Torres3, Maria MartinezGarcia2, Joan Albanell2, Adolfo Diez-Perez4, Ignasi Tusquets2, Xavier Nogues4. 1Institut Municipal D’Investigacio´ Me`dica, Spain, 2Medical Oncology Department, Breast Cancer Unit. Molecular Therapeutics & Biomarkers in Breast Cancer, Cancer Research Program, IMIM-Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain, Spain, 3 Department of Internal Medicine, URFOA IMIM-Hospital,RETICEF(Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain del Mar, Parc de Salut Mar, Autonomous University of Barcelona, Spain, 4 Department of Internal Medicine, URFOA IMIM-Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona,RETICEF(Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad), Instituto Carlos III, Barcelona, Spain, Spain Disclosures: Daniel Prieto-alhambra, None

MO0132

CT-based Rigidity Analysis Affects Treatment of Patients with Appendicular Metastasis Ara Nazarian*1, Vahid Entezari1, Robert Turcotte2, Megan Anderson1, Albert Aboulafia3, Patrick Lin4, Edward Cheng5, Richard Terek6, Mark Gebhardt1, Timothy Damron7, Brian Snyder8. 1Beth Israel Deaconess Medical Center, USA, 2McGill Medical Centre, Canada, 3 Sinai Hospital, USA, 4MDACC, USA, 5UMN, USA, 6RI hospital, USA, 7State University of New York Upstate Medical University, USA, 8Children’s Hospital Boston, Harvard Medical School, USA Disclosures: Ara Nazarian, None

MO0133

Curcuminoids Decrease Osteolytic Breast Cancer Bone Metastases Separate from Effects on Tumor Cell Growth Laura Wright* 1, Theresa Guise2, Khalid Mohammad2, Janet Funk3. 1The University of Arizona, USA, 2Indiana University, USA, 3University of Arizona Health Sciences Center, USA Disclosures: Laura Wright, None

MO0134

Effect of Exercise on Bone Strength, Body Composition and Physical Performance in Breast Cancer Patients- A 12-month RCT Riku Nikander*1, Harri Sievanen2, Katriina Ojala3, Pirkko-Liisa Kellokumpu-Lehtinen4, Tiina Palva 5, Carl Blomqvist 6, Riitta Luoto3, Tiina Saarto6. 1Metropolia University of Applied Sciences, Helsinki, Finland, Finland, 2UKK Institute, Finland, 3UKK Institute for Health Promotion Research, Finland, 4Tampere University Hospital, Finland, 5Pirkanmaa Cancer Society, Finland, 6Helsinki University Central Hospital, Finland Disclosures: Riku Nikander, None

MO0135

Monday

Osteocyte-derived FGF23 Stimulates Klotho-Positive Prostate Cancer Cells Pierrick Fournier*1, Erik Imel2, Daniel Edwards1, James Knight1, Noah Hahn1, John Chirgwin1. 1Indiana University, USA, 2Indiana University School of Medicine, USA Disclosures: Pierrick Fournier, None

MO0136

Runx2 ChIP-seq Gillian Little*, Ben Berman, Sanjeev Baniwal, Gerhard Coetzee, Baruch Frenkel. University of Southern California, USA Disclosures: Gillian Little, None

MO0137

Runx2 Controls a Positive Feedback Loop between Androgen Signaling and Prolactin-induced Protein (PIP) in promoting T47D Cell Proliferation Sanjeev Baniwal*, Gillian Little, Nyam-Osor Chimge, Baruch Frenkel. University of Southern California, USA Disclosures: Sanjeev Baniwal, None

MO0138

The Vitamin D Receptor has a Ligand-Independent Role in Human Breast Cancer Cell Growth Trupti Trivedi*1, Yu Zheng1, Li Laine Ooi1, Colette Fong-Yee1, Colin Dunstan2, Markus Seibel3, Dr. Hong Zhou3. 1Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 2University of Sydney, Australia, 3Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Trupti Trivedi, None

237

MO0139

Treatment with Interleukin 6 Receptor Antibodies Inhibits Prostate Cancer Growth in a Murine Model of Bone Metastasis Dennis Basel1, Yu Zheng2, Julian Kelly 1, Frank Buttgereit3, Robert L Sutherland4, Colin Dunstan5, Dr. Hong Zhou6, Markus Seibel*6. 1ANZAC Research Institute, the University of Sydney, Australia, 2Bone Research Program, ANZAC Research Institute, University of Sydney, Australia, 3Department of Rheumatology & Clinical Immunology, Charite´ University Medicine (CCM), Germany, 4Cancer Research Program, Garvan Institute of Medical Research, Australia, 5University of Sydney, Australia, 6Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Markus Seibel, None

MO0140

TWIST WR/Runx Domain Synergizes NF-kB Activity and Promotes Cellular Invasiveness through IL-8 Production Karen Aboody1, Shan Li 2, Raquel Raices3, Stephen Kendall4, GINA LOWE5, Carlotta Glackin*6. 1City of Hope Medical Center, USA, 2Beckman Research Institute Graduate School, USA, 3Stem Cell Technologies, USA, 4Fluidigm, USA, 5CITY OF HOPE/ BECKMAN RESEARCH INSTITUTE, USA, 6Beckman Research Institute at City of Hope, USA Disclosures: Carlotta Glackin, None

MO0141

VEGFR3 Expression in Human Breast Cancers and Effects of VEGFR3 Antibody in a Mouse Model of Metastatic Breast Cancer Yoshikazu Morita* 1, Lei Shu2, Kristina Subik2, Ping Tang2, Brendan Boyce2, Lianping Xing1. 1University of Rochester, USA, 2University of Rochester Medical Center, USA Disclosures: Yoshikazu Morita, None

MO0142

Vertebral Fractures and Trabecular Microstructure in Men with Prostate Cancer on Androgen Deprivation Therapy Julie Wagner*, Karen Vujevich, Megan Miller, Subashan Perera, Joel Nelson, Neil Resnick, Susan Greenspan. University of Pittsburgh, USA Disclosures: Julie Wagner, None

CANCER AND BONE: GENERAL MO0143

10 Years of Balloon Kyphoplasty in Malignant Vertebral Body Lesions - Critical Analysis of Benefits and Complications Dr. Max Markmiller*. Klinikum Kempten, Germany Disclosures: Dr. Max Markmiller, None

MO0144

A New Murine Model of Medulloblastoma Bone Metastasis Jessica Grunda*, James Mobley, Gregory Clines. University of Alabama at Birmingham, USA Disclosures: Jessica Grunda, None

MO0145

BTK Mediates SDF-1-Induced Migration of Myeloma Cells and Osteoclast Precursors, Osteoclastogenesis and Myeloma Cell Clonogenicity RAKESH BAM*, Angela Pennisi, Upparahalli Sathisha, Xin Li, Sharmin Khan, Yuping Wang, Wen Ling, Bart Barlogie, John Shaughnessy, Shmuel Yaccoby. University of Arkansas for Medical Sciences, USA Disclosures: RAKESH BAM, None

MO0146

Functional Inhibition of Osteoblastic Cells in an In Vivo Mouse Model of Myeloid Leukemia Benjamin Frisch*1, John Ashton2, Lianping Xing3, Michael Becker 2, Craig Jordan2, Laura Calvi1. 1University of Rochester School of Medicine, USA, 2University of Rochester School of Medicine & Dentistry, USA, 3University of Rochester, USA Disclosures: Benjamin Frisch, None

MO0147

Localized Tumor Growth in Bone: Quantification of Tumor Burden, Bone Destruction, and Weight Bearing Subba Chintalacharuvu*1, Jeffrey Wolos2, Elizabeth Misener 1, Christopher Bull1, Li Li 1, Kellie Brune3. 1Covance Laboratories, Inc., USA, 2Scientific Consultant, USA, 3Covance Laboratories, Inc., USA Disclosures: Subba Chintalacharuvu, None

238

MO0148

Longitudinal Monitoring of Osteolytic Bone Tumors with Integrated Optical-MicroCT Imaging Jeff Meganck*, Ning Zhang, Heng Xu, Ed Lim, Stanley Liang, Victor Ninov, Jay Whalen, Chaincy Kuo, Tammy Troy, Qing Feng, JaeBeom Kim, Brad Rice. Caliper Life Sciences, USA Disclosures: Jeff Meganck, Caliper Life Sciences, 3

MO0149

Partial Weightbearing for 21-Days and Low Dose High Energy Radiation Results In Cancellous and Cortical Bone Loss Brandon Macias*1, Florence Lima1, Yasaman Shirazi-Fard 1, David Cunningham1, Evelyn Yuen1, Kaleigh Camp1, Michael Wiggs 1, James D Fluckey1, Elizabeth S Greene1, Matthew Allen2, Leslie A Braby1, Harry Hogan1, Susan Bloomfield1. 1Texas A&M University, USA, 2 Indiana University School of Medicine, USA Disclosures: Brandon Macias, None

MO0150

RANK Ligand Regulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells Yuvaraj Sambandam*1, Kumaran Sundaram2, William Ries 1, Sakamuri Reddy2. 1Medical University of South Carolina, USA, 2Charles P. Darby Children’s Research Institute, USA Disclosures: Yuvaraj Sambandam, None

MO0151

RNA-Dependent Protein Kinase is Essential for 2-Methoxyestradiol-Induced Autophagy in Osteosarcoma Cells Caihong Yang, Kristen Shogren, Ribu Goyal, Michael Yaszemski, Avudaiappan Maran*. Mayo Clinic College of Medicine, USA Disclosures: Avudaiappan Maran, None

MO0152

Selective Targeting of the Ubiquitin Ligase Cbl Reduces Receptor Tyrosine Kinases Signaling and Osteosarcoma Tumorigenesis Nicolas Se´ve`re*1, Franc¸ois-Xavier Dieudonne´ 1, Caroline Marty1, Olivia Fromigue´ 1, Pierre Marie2. 1Inserm U606 & University Paris Diderot, France, 2INSERM Unit 606 & University Paris Diderot, France Disclosures: Nicolas Se´ve`re, None

MO0153

Serum 25-hydroxyvitamin D and Nuclear Grade in Patients with Ductal Carcinoma In Situ Mercedes Gacad*1, Nancy Greep1, Deborah Cunningham1, Jaime Shamonki2, MyungShin Sim1, Dave Hoon1, Armando Giuliano1, Frederick Singer1. 1John Wayne Cancer Institute, USA, 2Saint John’s Health Center, USA Disclosures: Mercedes Gacad, None

MO0154

Single Cytotoxic Agents Directly Cause Bone Loss due to Increased Osteoclastogenesis: Implications for Preventing Bone Loss in Cancer Patients. Julie Quach*1, Maria Askmyr 1, Tanja Jovic 1, Kirby White1, Emma Baker1, Nicole Walsh2, Louise Purton1. 1St. Vincent’s Institute, Australia, 2St Vincent’s Institute of Medical Research, Australia

MO0155

The Role of VEGF in the Progression of Human Osteosarcoma Paul Daft* 1, Jennifer Paige-Robinson2, Majd Zayzafoon 3. 1The University of Alabama At Birmingham, USA, 2University of Alabama-Birmingham, USA, 3University of Alabama at Birmingham, USA Disclosures: Paul Daft, None

MO0156

The Skeletal Effects of the Tyrosine Kinase Inhibitor Nilotinib Susannah O’Sullivan*1, Jian-Ming Lin 2, Maureen Watson2, Karen Callon2, Dorit Naot2, Pak Cheung Tong2, Anne Horne2, Opetaia Aati2, Fran Porteous2, Greg Gamble2, Jillian Cornish2, Peter Browett2, Andrew Grey 2. 1University of Auckland, Nzl, 2University of Auckland, New Zealand Disclosures: Susannah O’Sullivan, None

239

Monday

Disclosures: Julie Quach, None

DISORDERS OF MINERAL METABOLISM: CONGENITAL AND GENETIC BONE DISEASES MO0157

Bone-seeking Labels as Markers for Bone Formation in Sclerostin Knockout Mice Nicole Collette*1, Darren Hillegonds2, Kenneth Turteltaub1, Gabriela Loots3. 1Lawrence Livermore National Laboratory, USA, 2Lawrence Livermore National Library, USA, 3 LLNL/UC Merced, USA Disclosures: Nicole Collette, None

MO0158

Cellular Dysregulation of Gene Expression May Contribute to Matrix Hypermineralization in Osteogenesis Imperfecta Wayne Cabral*1, Nadja Fratzl-Zelman2, Paul Roschger 3, Klaus Klaushofer4, Adele Boskey5, Joan Marini6. 1NIH, NICHD, USA, 2Ludwig-Boltzmann Institute of Osteology, Austria, 3L. Boltzmann Institute of Osteology, Austria, 4Hanusch Hospital, Austria, 5 Hospital for Special Surgery, USA, 6National Institute of Child Health & Human Development, USA Disclosures: Wayne Cabral, None

MO0159

Generation of iPS Cells from Fibroblasts and Peripheral Blood Cells of CMD Patients I-Ping Chen*1, Xiaonan Xin1, Mary-Louise Stover1, Hui-Chen Chan1, Keiichi Fukuda2, Noemi Fusaki3, Akihiro Iida3, Mamoru Hasegawa3, Ernst Reichenberger 1, Alexander Lichtler1. 1University of Connecticut Health Center, USA, 2Keio University School of Medicine, Japan, 3DNAVEC Corporation, Japan Disclosures: I-Ping Chen, None

MO0160

The High Bone Mass Phenotype is Characterised by Increased Subcutaneous and Intramuscular Fat, but Decreased Marrow Fat Celia Gregson* 1, Adrian Sayers1, Victor Lazar2, Sue Steel2, Joern Rittweger3, Jon Tobias4. 1 University of Bristol, United Kingdom, 2Hull Royal Infirmary, United Kingdom, 3 Institute of Aerospace Medicine, German Aerospace Center, Germany, 4Musuloskeletal Reseach Unit, University of Bristol, United Kingdom Disclosures: Celia Gregson, None

DISORDERS OF MINERAL METABOLISM: OSTEOMALACIA/RICKETS MO0161

Assessement of Bone Associated Pain in the Aged Osteomalacic Rat Darshana Durup1, Jesper Ryhl Plovst1, Erik Frandsen 2, Solveig Petersen2, Lars Thorbjørn Jensen2, Niklas Jorgensen3, Anne-Marie Heegaard*1. 1Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, 2Glostrup University Hospital, Denmark, 3 Copenhagen University Hospital Glostrup, Denmark Disclosures: Anne-Marie Heegaard, None

MO0162

How High Dose(s) of Oral Vitamin D3 Can Correct Insufficiency in a Non Supplemented Rheumatologic Population? Olivier Lamy1, Didier Hans*2, Marc-Antoine Krieg 3, Jean Dudler1, Berengere Aubryrozier3, Delphine Stoll1. 1CHUV, Switzerland, 2Lausanne University Hospital, Switzerland, 3 University Hospital, Switzerland Disclosures: Didier Hans, None

DISORDERS OF MINERAL METABOLISM: PAGET’S DISEASE MO0163

Identification of Susceptibility Loci to Giant Cell Tumor and Paget’s Disease of Bone Daniela Merlotti*1, Fernando Gianfrancesco 2, Domenico Rendina3, Teresa Esposito2, Alessandra Mingione2, Daniela Formicola2, Riccardo Muscariello3, Pasquale Strazzullo3, Ranuccio Nuti1, Luigi Gennari1. 1University of Siena, Italy, 2Institute of Genetics & Biophysics, CNR, Italy, 3Department of Clinical & Experimental Medicine, Federico II University of Naples, Italy Disclosures: Daniela Merlotti, None

DISORDERS OF MINERAL METABOLISM: PARATHYROID DISEASES MO0164

A Prospective Study of Dietary Calcium and the Risk for Primary Hyperparathyroidism Gary Curhan1, Julie Paik*1, Eric Taylor2. 1Brigham & Women’s Hospital, USA, 2Maine Medical Center, USA Disclosures: Julie Paik, None

240

MO0165

Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in a Subset of Sporadic Parathyroid Adenomas Filomena Cetani*1, Simona Borsari2, Elena Pardi2, Elena Paltrinieri2, Benedetta Raspini2, Federica Saponaro2, Antonella Picone2, Piero Berti3, Paolo Miccoli 3, Claudio Marcocci1. 1 University of Pisa, Italy, 2University of Pisa Department of Endocrinology & Metabolism, Italy, 3University of Pisa Department of Surgery, Italy Disclosures: Filomena Cetani, None

MO0166

Case Report: Severe Renal Osteodystrophy in a 40 Year Old Female with End Stage Renal Disease Maria Princess Landicho* 1, Thelma Crisostomo 1, Pauline Camacho2. 1Makati Medical Center, Philippines, 2Loyola University of Chicago, USA Disclosures: Maria Princess Landicho, None

MO0167

Cushing’s Disease-Induced Osteoporosis: Evaluation at Diagnosis and Two, Five and Ten Years after Hypercortisolism Resolution Wallace Holanda-Miranda*1, Sergio Luchini Batista2, Aline Ramos1, Paula Elias1, Francisco Pereira3, Margaret Castro1, Ayrton Moreira1, Francisco Jose De Paula4. 1School of Medicine of Ribeirao Preto, USP, Brazil, 2School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil, 3University of Sergipe, School of Medicine of Sergipe, Brazil, 4School of Medicine of Ribeirao Preto - USP, Brazil Disclosures: Wallace Holanda-Miranda, None

MO0168

Effect of Long Term Stable Hypercalcemia on Kidney Function in the Elderly Sharon Lahiri1, Nayana Parikh1, Sudhaker Rao1, Manjari Devidi*2. 1Henry Ford Hospital, USA, 2St. Joseph Hospital, USA Disclosures: Manjari Devidi, None

MO0169

Long Term Safety of Vitamin D Replacement in Mild Primary Hyperparathyroidism Shila Begum1, Jacqueline Berry2, Peter Selby*2. 1Manchester Royal Infirmary, United Kingdom, 2Manchester University, United Kingdom Disclosures: Peter Selby, None

MO0170

Medical Care Costs for Persons with and without Prevalent Hypoparathyroidism: A Population-based Study. Cynthia Leibson*1, Bart Clarke2, Jeanine Ransom1, Hjalmar Lagast3. 1Mayo Clinic, Department of Health Sciences Research, USA, 2Mayo Clinic College of Medicine, USA, 3 NPS Pharmaceuticals, USA Disclosures: Cynthia Leibson, None

MO0171

PTH (1-84) Replacement Therapy in Hypoparathyroidism: Effects on Bone Metabolism and Structure Tanja Sikjaer*1, Lars Rejnmark1, Annemarie Bru¨el 2, Jesper Thomsen 2, Leif Mosekilde1. 1 Aarhus University Hospital, Denmark, 2University of Aarhus, Denmark Disclosures: Tanja Sikjaer, None

PTH(1-84) Lowers Circulating Sclerostin Levels in Hypoparathyroidism Aline Costa*1, Mishaela Rubin1, Jim Sliney Jr 2, Zachary Lenane1, Rebecca Ives2, Chiyuan Zhang1, Donald McMahon3, Serge Cremers1, John Bilezikian3. 1Columbia University, USA, 2Columbia University Medical Center, USA, 3Columbia University College of Physicians & Surgeons, USA Disclosures: Aline Costa, None

MO0173

Relationships Between Pharmacokinetic Profile of Human PTH(1-84) and Serum Calcium Response in Postmenopausal Women Following 4 Different Methods of Administration John Fox*, David Wells, Roger Garceau. NPS Pharmaceuticals, USA Disclosures: John Fox, NPS Pharmaceuticals, 1; NPS Pharmaceuticals, 5

MO0174

Simultaneous Quantitative Analysis of Vitamin D Receptor (VDR), Calcium Sensing Receptor (CaSR), Parathyroid Hormone (PTH) and Cyclin D1 mRNAs in Moderate to Severe Primary Hyperparathyroidism (PHPT) in Asian Indians Shweta Varshnay*1, Sanjay Bhadada2, Sudhaker Rao3, Uma Nahar1, Anil Bhansali4, Arunanshu Behera1, Ambrish Mithal5, Sadhna Sharma1. 1PGIMER,Chandigarh, India, 2 PGIMER,Chandigarh, Ind, 3Henry Ford Health System, USA, 4PGIMER,Chandigah, India, 5Medicity Hospital,Gurgaon, India Disclosures: Shweta Varshnay, None

241

Monday

MO0172

MO0175

Vitamin D Toxicity in a Patient with Surgical Hypoparathyroidism Chae Kim, Heather Hofflich*. University of California, San Diego, USA Disclosures: Heather Hofflich, None

DISORDERS OF MINERAL METABOLISM: RENAL BONE DISEASE MO0176

Decreased Trabecular Tissue Mineralization Is Associated with Fracture in Patients with Kidney Disease Thomas Nickolas*1, Xiaowei Liu2, Emily Stein2, Mafo Kamanda-Kosseh3, Ivelisse Colon1, Serge Cremers 3, Lucas Nikkel1, Chiyuan Zhang3, Donald McMahon2, Elizabeth Shane2. 1 Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA Disclosures: Thomas Nickolas, None

MO0177

Tests of Bone Density and Structure are Associated with Fractures in Stage 3-5 Chronic Kidney Disease Sophie Jamal*1, Sarah West2, Angela Cheung3, Charmaine E. Lok4. 1The University of Toronto, Canada, 2University of Toronto, Canada, 3University Health Network, Canada, 4 Toronto General Hospital, Canada Disclosures: Sophie Jamal, None

MO0178

The Influence of Growth Hormone Treatment on Bone Matrix Mineralization in Children with Chronic Kidney Disease Kamilla Nawrot-Wawrzyniak*1, Nadja Fratzl-Zelman1, Barbara M. Misof1, Paul Roschger 1, Sonja Lueger1, Małgorzata Pan´czyk-Tomaszewska2, Helena Zio´łkowska2, Klaus Klaushofer1. 1Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department; Hanusch Hospital Vienna, Austria, 2Department of Pediatrics & Nephrology Medical University of Warsaw, Poland Disclosures: Kamilla Nawrot-Wawrzyniak, None

DISORDERS OF MINERAL METABOLISM: RHEUMATOLOGIC AND OTHER SYSTEMIC ILLNESSES MO0179

Bone Metabolism in Diabetic Patient with or without Metabolic Syndrome Ran Cui*1, Shen Qu2, Hui Sheng3. 1Tenth People’s Hospital of Tongji University, Peoples Republic of China, 2Tongji University School of Medicine, Peoples Republic of China, 3 Shanghai, Fudan University, Peoples Republic of China Disclosures: Ran Cui, None

MO0180

Gene Expression Changes in Femoral Head Necrosis of Human Bone Tissue Janos Kosa*1, Bernadett Balla1, Csaba Pinte´r2, Ja´nos Podani3, La´szlo´ Kiss 4, Istvan Takacs5, Ga´bor Speer1, Zsolt Nagy5, Bala´zs Horva´th2, La´szlo´ Kora´nyi6, Peter Lakatos5. 1 Semmelweis University, Hungary, 2Csolnoky Ferenc Veszpre´m County Hospital, Hungary, 3Eo¨tvo¨s Lora´nd University, Hungary, 4Hete´nyi Ge´za County Hospital, Hungary, 5 Semmelweis University Medical School, Hungary, 6Drug Research Center, Hungary Disclosures: Janos Kosa, None

MO0181

Increased Visceral Adiposity during Anti TNFa Treatment for Inflammatory Rheumatic Disease is Associated with Various Changes on Serum Adipokines: A 2 years Prospective Study Eric Toussirot*1, Laurent Mourot2, Nhu uyen Nguyen3, Malika Bouhaddi 3, Daniel Wendling4, Gilles Dumoulin5. 1University Hopsital J Minjoz, France, 2EA3920 Physiopathologie Cardiovasculaire et Pre´vention, France, 3Explorations fonctionnelles Physiologie, Minjoz Hospital, France, 4University Hospital Minjoz, France, 5Explorations fonctionnelles biochimie endocrinienne et me´tabolique Minjoz Hospital, France Disclosures: Eric Toussirot, None

MO0182

Toll-like Receptor 2 Heterodimer, TLR1/2 and TLR 2/6, Induces Inflammatory Bone Loss via PGE2 Production by Osteoblasts Chiho Matsumoto*, Tsukasa Tominari, Toshio Oda, Michiko Hirata, Masaki Inada, Chisato Miyaura. Tokyo University of Agriculture & Technology, Japan Disclosures: Chiho Matsumoto, Tokyo University of Agriculture and Technology, 3

242

DISORDERS OF MINERAL METABOLISM: TRANSPLANTATION MO0183

Vertebral Deformity in Patients with End Stage Renal Disease. Eual Phillips*1, Mary Leonard2, Chamith Rajapakse3, Michael Wald4, Yusuf Bhagat1, Felix Werner Wehrli4. 1University of Pennsylvania, USA, 2Children’s Hospital of Philadelphia, USA, 3University of Pennsylvania School of Medicine, USA, 4University of Pennsylvania Medical Center, USA Disclosures: Eual Phillips, None

DISORDERS OF MINERAL METABOLISM: VASCULAR AND ECTOPIC CALCIFICATION MO0184

Cellular Cholesterol Metabolism is required for Vascular Cell Calcification Jeff Hsu* 1, Yifan Geng1, Jinxiu Lu1, Linda Demer2, Yin Tintut1. 1University of California, Los Angeles, USA, 2David Geffen School of Medicine At University of California Los Angeles, USA Disclosures: Jeff Hsu, None

MO0185

The Appearance and Modulation of Osteocyte Marker Expression During Calcification of Vascular Smooth Muscle Cells. Dongxing Zhu1, Neil Mackenzie1, Jose Luis Millan2, Colin Farquharson*3, Vicky Macrae1. 1 The Roslin Institute, University of Edinburgh, United Kingdom, 2Sanford-Burnham Medical Research Institute, USA, 3Roslin Institute, University of Edinburgh, United Kingdom Disclosures: Colin Farquharson, None

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: GENERAL STUDIES MO0186

Bone Geometry, Density and Microarchitecture in Patients with Type I Osteogenesis Imperfecta Compared with Age and Sex Matched Healthy Controls Utilizing High-Resolution Peripheral Quantitative Computed Tomography Lars Folkestad* 1, Jannie Dahl Hald2, Stinus Hansen3, Jeppe Gram4, Bente Langdahl5, Bo Abrahamsen6, Kim Brixen7. 1Department of Endocrinology, Odense University Hospital / 3Department of Endocrinology, Hospital of Southwest Denmark / Institute of Clinical Research, University of Southern Denmark, Denmark, 2Department of Endocrinology & Internal Medicine, Aarhus University Hospital, Denmark, 3Department of Endocrinology, Odense University Hospital / Institute of Clinical Research, University of Southern Denmark /, Denmark, 4Department of Endocrinology, Hospital of Southwest Denmark, Denmark, 5 Department of Endocrinology & Internal Medicine, Denmark, 6Department of Internal Medicine, Gentofte Hospital / Institute of Clinical Research, University of Southern Denmark, Denmark, 7Department of Endocrinology, Odense University Hospital / Institute of Clinical Research, University of Southern Denmark, Denmark Disclosures: Lars Folkestad, None

Dental Phenotype in a Mouse Model for Craniometaphyseal Dysplasia Eliane Dutra*, I-Ping Chen, Peter Maye, Ernst Reichenberger. University of Connecticut Health Center, USA Disclosures: Eliane Dutra, None

MO0188

Determination and Comparison of Serum and Plasma Sclerostin Concentrations by Commercially Available Enzyme-Linked Immunoassays Melissa McNulty1, Ravinder Singh1, Eric Bergstralh1, Xujian Li 1, Rajiv Kumar*2. 1Mayo Clinic, USA, 2Mayo Clinic College of Medicine, USA Disclosures: Rajiv Kumar, None

MO0189

Epidemiogenetic Study of French Families Affected by Paget’s Disease of Bone Laetitia Michou*1, Corinne Collet 2, Jean Morissette3, Maurice Audran4, Thierry Thomas5, Edith R. Gagnon3, Jean-Marie Launay2, Jean-Louis Laplanche2, Jacques Brown6, Philippe Orcel7. 1Centre De Recherche Du Chuq-Chul, Canada, 2Service de biochimie et biologie mole´culaire, Hoˆpital Lariboisie`re, APHP, France, 3Centre de recherche du CHUQ CHUL, Canada, 4Universite´ et CHU Angers; INSERM U922, France, 5Hoˆpital Nord CHU de St-Etienne, France, 6Laval University, Canada, 7University Paris Diderot, France Disclosures: Laetitia Michou, Warner Chilcott, 8; Eli Lilly, 8; Eli Lilly, 2; Amgen, 8; CIHR, 2; Roche, 8

243

Monday

MO0187

MO0190

Implication of Gender Difference in the Association between Bone-specific Alkaline Phosphatase Activity and Serum Biochemical Parameters or Dietary Nutrients Mayu Haraikawa1, Rieko Tanabe2, Natsuko Sogabe3, Aoi Sugimoto4, Toshimi Michigami5, Takayuki Hosoi6, Masae Goseki-Sone* 7. 1Graduate School of Human Life Science, Japan Women’s University, Japan, 2Division of Nutrition, Department of Food & Nutrition, Faculaty of Human Sciences & Design, Japan Women’s University, Japan, 3 Department of Health & Nutrition Sciences, Faculty of Human Health, Komazawa Women’s Univeristy, Japan, 4Graduate School of Human Sciences & Design, Division of Food & Nutrition, Japan Women’s University, Japan, 5Osaka Medical Center, Research Institute for Maternal & Child Health, Japan, 6National Center for Geriatrics & Gerontology, Japan, 7Japan Women’s University, Japan Disclosures: Masae Goseki-Sone, None

MO0191

Mutations in NOTCH2 in Patients with Hajdu-Cheney Syndrome Michael Mannstadt*1, Wenping Zhao2, Karen Miller2, Rachel Gafni3, Michael Collins3, Margaret Seton2, Harald Jueppner2. 1Massachusetts General Hospital Harvard Medical School, USA, 2Massachusetts General Hospital, USA, 3National Institutes of Health, USA Disclosures: Michael Mannstadt, None

MO0192

Serum Levels of Dkk1, Sclerostin and Secreted Frizzled Related Protein 4 are not Changed in Individuals with Gain-of-function Mutations in LRP5 Christine Simpson*, Grace Lee, Dinah Foer, Benhua Sun, Joseph Belsky, Karl Insogna. Yale University School of Medicine, USA Disclosures: Christine Simpson, None

MO0193

The Bone Tissue Defect in Children with Hypophosphatasia: Histomorphometric Study Frank Rauch*1, Cheryl Greenberg2, Michael Whyte3, Hal Landy4, Rose Travers1, Francis Glorieux5. 1Shriners Hospital for Children, Canada, 2University of Manitoba, Children’s Hospital, Canada, 3Shriners Hospital for Children, USA, 4Enobia Pharma, Canada, 5 Shriners Hospital for Children & McGill University, Canada Disclosures: Frank Rauch, Enobia Pharma, 2

GENETIC DISORDERS OF BONE AND MINERAL METABOLISM: LINKAGE STUDIES AND POLYMORPHISMS MO0194

Determining the Repertoire of Human Genes Bound by Osterix (SP7) Kurt Hankenson*1, Jianhua Zhao2, Fengchang Zhu1, Struan Grant3. 1University of Pennsylvania, USA, 2Children’s Hospital of Philadelphia, USA, 3Children’s Hospital of Philadelphia, USA Disclosures: Kurt Hankenson, None

MO0195

Genome-Wide Association Analysis of Hip Structure Phenotypes in the Fels Longitudinal Study Stefan Czerwinski*1, Miryoung Lee1, Bradford Towne1, Joanne Curran2, Thomas Dyer2, Audrey Choh1, John Blangero2, Roger Siervogel1. 1Wright State University Boonshoft School of Medicine, USA, 2Texas Biomedical Research Institute Department of Genetics, USA Disclosures: Stefan Czerwinski, None

MO0196

Heterogeneous Stock Rat: a Unique Genetic Resource for Rapid and Efficient Discovery of the Genetic Determinants of Bone Fragility Imranul Alam*1, Daniel Koller1, Sun Qiwei1, Ryan Roeder2, Toni Can˜ete 3, Gloria Bla´zquez3, Regina Lo´pez-Aumatell4, Esther Martı´nez-Membrives 3, Elia Vicens-Costa5, Carme Mont3, Sira Dı´az 3, Adolf Toben˜a 3, Alberto Ferna´ndez-Teruel3, Adam Whitley4, Pernilla Strid6, Margarita Diez6, Martina Johannesson4, Jonathan Flint4, Michael Econs1, Charles Turner7, Tatiana Foroud8. 1Indiana University School of Medicine, USA, 2 University of Notre Dame, USA, 3Autonomous University of Barcelona, Spain, 4 Wellcome Trust Center for Human Genetics, United Kingdom, 5Autonomous Unviersity of Barcelona, Spain, 6Karolinska Institutet, Sweden, 7Orthopaedic Surgery, USA, 8Indiana University Purdue University Indianapolis, USA Disclosures: Imranul Alam, None

MO0197

Identification of Lpin1 as a Candidate Gene for a Quantitative Trait Locus for Bone Mineral Density Cheryl Ackert-Bicknell*1, Dana Godfrey1, Yaoyu Chen2, Beverly Paigen1. 1The Jackson Laboratory, USA, 2University of Massachusetts Medical School, USA Disclosures: Cheryl Ackert-Bicknell, None

244

MO0198

Meta-Analysis of Genome-Wide Association Study Identifies Three Loci Influencing Serum Osteoprotegerin Levels Ching-Lung Cheung*1, Yi-Hsiang Hsu2, Joel Eriksson3, Johnny Kwan4, David Karasik5, Emelia Benjamin6, Joa˜o Fontes7, Douglas Kiel5, Mattias Lorentzon8, Martin Larson9, Annie Kung10, Claes Ohlsson11, Pak-Chung Sham12, Jose´e Dupuis13. 1The University of Hong Kong, Hong Kong, 2Hebrew SeniorLife Institute for Aging Research & Harvard Medical School, USA, 3Center for Bone & Arthritis Research, Departments of Internal Medicine & Geriatrics, Sahlgrenska Academy, University of Gothenburg, Sweden, 4Hong Kong University, Hong Kong, 5Hebrew SeniorLife, USA, 6Department of Medicine, Boston University Schools of Medicine; Dept of Epidemiology, Boston University School of Public Health, Boston, MA; Framingham Heart Study of the National, Heart, Lung, & Blood Institute & Boston University, Framingham, USA, 7Cardiology Section, Boston University Schools of Medicine, Boston; Framingham Heart Study of the National, Heart, Lung, & Blood Institute & Boston University, Framingham, USA, 8Center for Bone Research at the Sahlgrenska Academy, Sweden, 9 Framingham Heart Study of the National, Heart, Lung, & Blood Institute & Boston University, Framingham; Department of Mathematics & Statistics, Boston University, Boston, USA, 10Dr. Kung-Wai Chee Clinic, Hong Kong, 11Centre for Bone & Arthritis Research, Sweden, 12Department of Psychiatry, the University of Hong Kong, Hong Kong, 13Framingham Heart Study of the National, Heart, Lung, & Blood Institute & Boston University, Framingham; Department of Biostatistics, Boston University School of Public Health, Boston, USA Disclosures: Ching-Lung Cheung, None

GROWTH FACTORS AND CYTOKINES: BONE MORPHOGENETIC PROTEINS MO0199

BMP Signaling Inhibits Myogenesis and Induces Osteoblastic Differentiation in Satellite Cells During Muscle Regeneration Hiroki Sasanuma 1, Katsumi Yoneyama1, Satoshi Ohte2, Masashi Shin2, Shoichiro Kokabu1, Toru Fukuda1, Takenobu Katagiri*3. 1Saitama Medical University RCGM, Japan, 2Saitama Medical University, Japan, 3Saitama Medical University Research Center for Genomic Medicine, Japan Disclosures: Takenobu Katagiri, None

MO0200

Increasing canonical Wnt signaling does not rescue the fracture phenotype of mice lacking Bmp2 Giuseppe Intini*, Luciane Capelo, Karen Cox, Vicki Rosen. Harvard School of Dental Medicine, USA Disclosures: Giuseppe Intini, None

GROWTH FACTORS AND CYTOKINES: FIBROBLAST GROWTH FACTORS MO0201

Disclosures: Kyung-Ae Yoon, None

GROWTH FACTORS AND CYTOKINES: GENERAL MO0202

A Novel Role for the Estrogen Responsive Cytokine, Lipocalin-2, in Bone Muzaffer Cicek*1, John Hawse2, Sarah Grygo3, Kevin Pitel4, Kenneth Peters3, Nalini Rajamannan5, Malayannan Subramaniam1, Thomas Spelsberg1. 1Mayo Clinic, USA, 2 Mayo Clinic College of Medicine, USA, 3Mayo Clinic College of Medicine, USA, 4 University of Minnesota, USA, 5Northwestern University Medical School, USA Disclosures: Muzaffer Cicek, None

MO0203

Alveolar Bone Repair under Homeostatic Conditions: Modulation of Inflammatory and Osteogenenic Processes by IL-10 and TNF-a Andreia Vieira*1, Carlos Eduardo Repeke2, Elcia Maria Silveira3, Carolina Favaro Francisconi3, Raissa Goncalves Carneiro Spera Andrade3, Ana Paula Favaro Trombone3, Gerson Francisco Assis3, Rumio Taga3, Gustavo Pompermaier Garlet3. 1Bauru School of Dentistry - University of Sao Paulo, Brazil, 2Bauru School of Dentistry - University of Sa˜o Paulo (FOB -USP), Brazil, 3Bauru School of Dentistry - University of Sa˜o Paulo (FOB - USP), Brazil Disclosures: Andreia Vieira, None

245

Monday

The Pattern of CXCR2-related Chemokine Gene Expression by FGF2 in the Osteoblast and Endothelial Cells Supports the Mobilization of Hematopoietic Stem and Progenitor Cells. Je-Yoel Cho1, Kyung-Ae Yoon*2, Hey-Sim Cho3. 1School of Dentistry, Kyungpook National University, South Korea, 2Kyungpook National University, South Korea, 3 School of dentistry, Kyungpook National University, South Korea

MO0204

Hedgehog Signaling Pathway Implicated in Oxysterol-Mediated Osteogenesis in Rabbit Bone Marrow Stromal Cells Sarah Sorice*1, Akishige Hokugo1, Kenneth Fan1, Vicente Meliton2, Patricia Zuk1, Weibiao Huang3, Timothy Miller1, Farhad Parhami 2, Reza Jarrahy1. 1Division of Plastic & Reconstructive Surgery, David Geffen School of Medicine at UCLA, USA, 2Department of Medicine, David Geffen School of Medicine at UCLA, USA, 3Plastic Surgery Section, VA Greater LA Healthcare System, Division of Plastic Surgery, USA Disclosures: Sarah Sorice, None

MO0205

Withdrawn

MO0206

Inhibition of Adipocytogenesis by Canonical WNT Signaling in Human Mesenchymal Stem Cells Longxiang Shen1, Julie Glowacki 2, Shuanhu Zhou*2. 1Brigham & Women’s Hospital, USA, 2Brigham & Women’s Hospital, USA Disclosures: Shuanhu Zhou, None

MO0207

Microarray Analysis of Fracture Gene Expression in Response to Cox-2 Gene Therapy Identifies Novel Angiogenic Genes Charles Rundle*, Nicoleta Popa, Subburaman Mohan, K-H. William Lau. Jerry L. Pettis Memorial VA Medical Center, USA Disclosures: Charles Rundle, None

MO0208

Nerve Growth Factor (NGF) Promotes Dental Epithelial Cell Proliferation Mariko Ono*, Tsutomu Iwamoto, YU SUGAWARA, Aya Yamada, Takashi Nakamura, Satoshi Fukumoto. Tohoku University Graduate School of Dentistry, Japan Disclosures: Mariko Ono, None

MO0209

Oncostatin M Is a Potent Regulator of Interleukin-6 and RANKL Expression in Mouse Synovial Fibroblasts and Synergises with Interleukin-1 Benoit Le Goff1, Brett A. Tonkin1, Sofie Singbrant1, T. John Martin1, Evange Romas2, Natalie Sims3, Nicole Walsh*1. 1St Vincent’s Institute of Medical Research, Australia, 2 Department of Medicine, St Vincent’s Hospital, University of Melbourne, Australia, 3St. Vincent’s Institute of Medical Research, Australia Disclosures: Nicole Walsh, None

MO0210

Protease-Activated Receptor-2 is Required for Normal Skeletal Growth and Repair Smitha R Georgy1, Charles N. Pagel1, Natalie Sims 2, Eleanor Mackie* 3. 1School of Veterinary Science, University of Melbourne, Australia, 2St. Vincent’s Institute of Medical Research, Australia, 3University of Melbourne, Australia Disclosures: Eleanor Mackie, None

MO0211

Skeletal Phenotype of the Leptin Receptor-Deficient Db/Db Mouse Garry Williams*1, Karen Callon1, Maureen Watson1, Jessica Costa2, Yaoyao Ding1, Michelle Dickinson1, Yu Wang3, Dorit Naot1, Ian Reid1, Jillian Cornish1. 1University of Auckland, New Zealand, 2University of Auckland, Nzl, 3University of Hong Kong, Hong Kong Disclosures: Garry Williams, None

MO0212

Study on Structure and Function of Sclerostin by Site Directed Mutagenesis of Cysteine- Knot and Finger 2 residues Kwang Joon Kim1, Ajitha Jami2, Kyoung Min Kim1, Sung-Kil Lim1, Gadi Jogeswar*3, Eun Jin Kim4, Sena Hwang1. 1Division of Endocrinology & Endocrine Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, South Korea, 2 Brain Korea 21 Project for medical sciences, Yonsei University College of Medicine, South Korea, 3Yonsei University College of Medicine Seoul South Korea, South Korea, 4 Severance Biomedical Science Institute, Yonsei University College of Medicine, South Korea Disclosures: Gadi Jogeswar, None

246

MO0213

Systemic Bone Metabolism and Inflammation in RA Patients Receiving TNF Inhibiting Therapy Won Park*1, Mie Jin Lim2, Seong Ryul Kwon1, Kowoon Ju1, Min Jung Son1. 1Inha University Hospital, South Korea, 2Division of Rheumatology, Department of Internal medicine, Inha University, South Korea Disclosures: Won Park, None

MO0214

Targeted Deletion of Chemokine Receptor (Ccr)-3 Increases Trabecular Bone Density in Mice Bouchra Edderkaoui*, Yan Hu, Anil Kapoor, Subburaman Mohan. Jerry L. Pettis Memorial VA Medical Center, USA Disclosures: Bouchra Edderkaoui, None

GROWTH FACTORS AND CYTOKINES: INSULIN-LIKE GROWTH FACTORS AND BINDING PROTEINS MO0215

Circulating Liver Derived IGF-1 is Dispensable for the Osteogenic Response to Mechanical Loading in Female Mice Johan Svensson1, Sara Windahl*1, Leanne Saxon2, Klara Sjo¨gren 1, Joanna Price3, Lance Lanyon2, Claes Ohlsson4. 1Center for Bone & Arthritis Research, Sweden, 2Royal Veterinary College, United Kingdom, 3University of Bristol, United Kingdom, 4Centre for Bone & Arthritis Research, Sweden Disclosures: Sara Windahl, None

GROWTH FACTORS AND CYTOKINES: REPRODUCTIVE HORMONES OTHER THAN ESTROGEN MO0491

TSH and Bone: An Update L. Sun*, R. Baliram, L.L. Zhu, R. Latif, G. Colaianni, T. Yuen, G. Zhu, J. Berkowitz, Y. Peng, S. Fritz, J. Li, J. Iqbal, T.F. Davies, M. Zaidi. The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, USA Disclosures: L. Sun, None

OSTEOBLASTS: APOPTOSIS AND CELL CYCLE MO0216

Adhesion to Apatite Surfaces Is Capable of Manipulating MAPK signaling and Osteogenesis in Human Adipose-derived Stem Cells Patricia Zuk*1, Benjamin Wu 2, Christopher Arakawa2, Eric Tsang2. 1UCLA, USA, 2 UCLA Dept of Bioengineering, USA Disclosures: Patricia Zuk, None

MO0217

Salubrinal Reduces Apoptosis of Mesenchymal Stem Cells and Osteoblasts Induced by Stress to the Endoplasmic Reticulum Liming Zhao1, Hiroki Yokota*2. 1Purdue University School of Indianapolis, USA, 2 Indiana University Purdue University Indianapolis, USA Disclosures: Hiroki Yokota, None

Monday

OSTEOBLASTS: BONE FORMATION AND BONE RESORPTION MO0218

Abnormal Mechanical Environment Affects the Morphology, Cytoskeleton and Cyotoskeleton-Associated Proteins Expression in Bone Cells Airong Qian*1, Lifang Hu 2, Xiang Gao 2, Wei Zhang2, Shengmeng Di 2, Peng Shang2. 1 Northwestern Polytechnical University, Peoples Republic of China, 2Northwestern Polytechnical University, China Disclosures: Airong Qian, None

MO0219

Afamin, Secreted from Non-Resorbing Osteoclasts, Acts as a Chemokine for Preosteoblasts via Akt and Gi-coupled Receptor Signaling Pathway Beom-Jun Kim*1, Sun-Young Lee2, Young-Sun Lee2, Seung Hun Lee 3, Sung Jin Bae1, Ha Young Kim4, Jung-Min Koh 1, Hong-Hee Kim5, Shin-Yoon Kim6, Ghi Su Kim7. 1Asan Medical Center, South Korea, 2Asan Institute for Life Sciences, South Korea, 3Asan Medical Center, University of Ulsan College of Medicine, South Korea, 4Wonkwang University Sanbon Hospital, South Korea, 5Seoul National University, South Korea, 6 Kyungpook National University Hospital, South Korea, 7University of Ulsan, South Korea Disclosures: Beom-Jun Kim, None

247

MO0220

Bone Sialoprotein and Runx2 Are Interdependent during Osteogenic Differentiation of Adult Mesenchymal Stem Cells Qinghua Lu, Marianna Rodova, James Bernard, Jinxi Wang*. University of Kansas Medical Center, USA Disclosures: Jinxi Wang, None

MO0221

Both TNF-a and RANKL Antagonist Peptide Stimulates Bone Formation In TNF-a Deficient Mice to the Same Extent As In Wild Type Mice. Masud Khan*1, Neil Alles 2, Kenichi Nagano3, Yuriko Furuya4, Hisataka Yasuda5, Keiichi Ohya3, Kazuhiro Aoki3. 1Tokyo Medical & Dental University G-COE, Japan, 2JSPS, Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Japan, 4 Oriental Yeast Co.,Ltd, Japan, 5Oriental Yeast Company, Limited, Japan Disclosures: Masud Khan, None

MO0222

CD47 is an Integral Modulator of Osteoblastogenesis Victoria Demambro* 1, Laura Maile2, Casey Doucette1, Phuong Le1, Wesley Beamer3, David Clemmons2, Clifford Rosen4. 1Maine Medical Center Research Institute, USA, 2 University of North Carolina Chapel Hill, USA, 3The Jackson Laboratory, USA, 4Maine Medical Center, USA Disclosures: Victoria Demambro, None

MO0223

Delayed Fracture Repair in mice lacking the dystrophin gene Celine Colnot1, Shirley Lieu2, Yan Yiu Yu*3, Theodore Miclau2. 1INSERM, France, 2 University of California, San Francisco, USA, 3UCSF, USA Disclosures: Yan Yiu Yu, None

MO0224

Epigenetic Mechanisms Modulate the Expression of Genes Controlling Osteoclast Differentiation Jesus Delgado-Calle* 1, Carolina San˜udo2, Agustin F. Ferna´ndez3, Raul Garcı´a-Renedo4, Mario F. Fraga3, Jose Riancho5. 1IFIMAV-H.U. Marque´s de Valdecilla-University of Cantaria, Spain, 2Department of Internal Medicine. Hospital U.M. Valdecilla-IFIMAVUniversity of Cantabria. RETICEF. Santander, Spain, Spain, 3Cancer Epigenetics Laboratory. Instituto Universitario de Oncologı´a del Principado de Asturias (IUOPA), HUCA, University of Oviedo. Oviedo, Spain, Spain, 4Department of Orthopaedic surgery & Traumatology. Hospital U.M. Valdecilla. Santander, Spain, Spain, 5University of Cantabria, Spain Disclosures: Jesus Delgado-Calle, None

MO0225

Fate of the Chondrocyte-Like Cells in Chondroid Bone during Distraction Osteogenesis in the Rabbits Mitsuhiko Takahashi1, Tetsuya Enishi*2, Shinjiro Takata3, Toshihiko Nishisho4, Takao Tsuneki1, Natsuo Yasui5. 1Orthopedics, Japan, 2The University of Tokushima Faculty of Medicine, Japan, 3Institute of Health Biosciences, University of Tokushima Graduate School, Japan, 4The University of Tokushima, Institute of Health Bioscience, School of Medicine, Japan, 5University, Japan Disclosures: Tetsuya Enishi, None

MO0226

Glutathione Role on Specific Markers of the Bone Remodeling Cecilia Romagnoli*, Gemma Marcucci, Roberto Zonefrati, Carmelo Mavilia, Gianna Galli, Annalisa Tanini, Teresa Iantomasi, Maria Teresa Vincenzini, Maria Luisa Brandi. University of Florence, Italy Disclosures: Cecilia Romagnoli, None

MO0227

Ibuprofen Administered Pre- or Post- Simulated Resistance Exercise Training Does Not Diminish Gains in Bone Formation or Bone Mass David Arthur Cunningham*, Kaleigh Camp, Evelyn Yuen, Brandon Macias, Stuart Solomon, Harry Hogan, Susan Bloomfield. Texas A&M University, USA Disclosures: David Arthur Cunningham, None

248

MO0228

Influence of Antiplatelet Drugs In the Pathogenesis of Experimental Periodontitis And Periodontal Repair In Rats Leila Coimbra*1, Carlos Rossa Junior2, Morgana Rodrigues Guimara˜es2, Raquel Fernanda Gerlach3, Marcelo Nicola´s Muscara´4, Denise Madalena Palomari Spolidorio2, Bruno Schneider Herrera2, Luis Carlos Spolidorio2. 1University of Sa˜o Paulo State, Brazil, 2 Araraquara Dental School, Brazil, 3Ribeira˜o Preto Dentistry School, Brazil, 4Institute of Biomedical Sciences, Brazil Disclosures: Leila Coimbra, None

MO0229

Osteoblast Targeted Deletion of FIP200, an Essential Component of Mammalian Autophagy Leads to Osteopenia in Mice Dongye Yang1, Jaclynn Kreider1, Paul Krebsbach2, Steven Goldstein3, Jun-Lin Guan1, Fei Liu*4. 1University of Michigan, USA, 2Univ of Michigan, Sch of Dentistry, USA, 3 University of Michigan Orthopedic Research Labs, USA, 4University of Michigan School of Dentistry, USA Disclosures: Fei Liu, None

MO0230

T Cell Subsets Differently Regulate Osteogenic Differentiation of Human Mesenchymal Stromal Cells Francesco Grassi*1, Luca Cattini2, Anna Piacentini2, Cristina Manferdini2, Elena Gabusi2, Andrea Facchini2, Gina Lisignoli2. 1Istituti Ortopedici Rizzoli, Italy, 2Ramses Lab. Rizzoli Orthopedic Institute, Italy Disclosures: Francesco Grassi, None

MO0231

The Role of the Extracellular Signal-Regulated Kinase (Erk)-Mapk Pathway In Osteoblasts During Post-Natal Bone Healing Jason Long*1, Xiang Zhao2, Christopher D. Beale 1, Casey A. Boyle1, Steven Goldstein3, Renny Franceschi1. 1UNIVERSITY OF MICHIGAN, USA, 2University of Michigan, School of Dentistry, USA, 3University of Michigan Orthopedic Research Labs, USA Disclosures: Jason Long, None

MO0232

Ursodeoxycholic Acid Neutralizes the Detrimental Effects of Lithocholic Acid and Bilirubin on Osteoblasts. Silvia Ruiz-Gaspa`* 1, Marta Dubreuil1, Angels Martinez-Ferrer2, Anna Enjuanes3, Pilar Peris4, MaJesus Martinez de Osaba3, Luisa Alvarez1, Ana Monegal3, Andres Combalia3, Albert Pare´s 1, Nuria Guanabens 5. 1CIBERehd, Hospital Clinic, IDIBAPS, University of Barcelona., Spain, 2Hospital Clinic Barcelona, Spain, 3Hospital Clinic, IDIBAPS, University of Barcelona., Spain, 4Hospital Clinic of Barcelona, Spain, 5Universitat De Barcelona, Spain Disclosures: Silvia Ruiz-Gaspa`, None

MO0233

Disclosures: Daniela Sousa, None MO0234

Beta1 Integrin Expression In Osteoblast Progenitors Is Required for Bone Formation NIna Kawelke, Matthaeus Vasel, Carina Wuerfel, Christine Hoffmann, Inaam Nakchbandi*. Max-Planck Institute for Biochemistry & University of Heidelberg, Germany Disclosures: Inaam Nakchbandi, None

MO0235

Y-Tocotrienol inhibits RANKL Gene Expression and Reduces Osteoclast Formation by an HMG-CoA Reductase Dependent Mechanism Wenxi Li*, Yuedi Ding, Jun Fan, Ying Peng, Runlin Yang, Lili Deng, Xiaohua Qiu, Tingting Shu, Qiang Fu. Key Laboratory of Nuclear Medicine, Ministry of Health; Jiangsu Key Laboratory of Molecular Nuclear Medicine; Jiangsu Institute of Nuclear Medicine., China Disclosures: Wenxi Li, None

249

Monday

Y1 Receptor Antagonism Increases Bone Formation in Mice Daniela Sousa*1, Ron Enriquez2, Amanda Sainsbury2, Paul A. Baldock2, Meriem Lamghari1, Herbert Herzog2. 1INEB - Instituto de Engenharia Biome´dica, Portugal, 2 Garvan Institute of Medical Research, Australia

OSTEOBLASTS: GENE EXPRESSION AND TRANSCRIPTION FACTORS MO0236

Cbf-b has a Positive Role on Postnatal Bone Formation by Regulating Runx2 Stability Suk-Chul Bae1, Ichiro Taniuchi2, Shin-Yoon Kim3, Jung-Eun Kim4, MIN-SU HAN5, NARAE PARK6, Kyung-eun Lim* 7, Jae-Hwan Jeong7, Je-Yong Choi7. 15Depat. of Biochemistry, School of Medicine, Institute for Tumor Research, Chungbuk National University, South Korea, 23Institute of Physical & Chemical Research, Research Center for Allergy & Immunology, Japan, 3Kyungpook National University Hospital, South Korea, 4 Kyungpook National University School of Medicine, South Korea, 5Republic of Korea, 6 Kyungpook National University, Republic of Korea, 7Kyungpook National University, School of Medicine, South Korea Disclosures: Kyung-eun Lim, None

MO0237

Cnot3, a Crucial Factor of mRNA Stability, Controls Osteoblastic Differentiation Chiho Watanabe*1, Masahiro Morita2, Yoichi Ezura3, Tetsuya Nakamoto1, Tadayoshi Hayata4, Hiroaki Hemmi5, Takuya Notomi6, Keiji Moriyama1, Tadashi Yamamoto2, Masaki Noda1. 1Tokyo Medical & Dental University, Japan, 2Division of Oncology, Institute of Medical Science, University of Tokyo, Japan, 3Tokyo Medical & Dental University, Medical Research Insititute, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5Immunology Frontier Research Center, Osaka University, Japan, 6GCOE, Tokyo Medical & Dental University, Japan Disclosures: Chiho Watanabe, None

MO0238

Essential role of Intraflagellar transport 80 in osteoblast differentiation through regulating Ihh/Gli and Wnt signaling pathways. Changdong Wang1, Shuying Yang*2. 1State University of New York at Buffalo, USA, 2 State University of New York @ Buffalo, USA Disclosures: Shuying Yang, None

MO0239

Foxo1 Mediates IGF1/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in osteoblasts Shengyong Yang*1, Haiyan Xu2, Shibing Yu3, Huiling Cao4, Jie Fan4, Chunxi Ge5, Renny Franceschi6, Henry Dong7, Guozhi Xiao4. 1VA Pittsburgh Healthcare System, USA, 2 Rhode Island Hospital, Brown Medical School, USA, 3University of Pittsburgh Medical Center, USA, 4University of Pittsburgh School of Medicine, USA, 5University of Michigan School of Dentistry, USA, 6University of Michigan, USA, 7Children’s Hospital of Pittsburgh, University of Pittsburgh, USA Disclosures: Shengyong Yang, None

MO0240

Genome-wide Analysis of Epigenetic Transcriptional Control by Runx2 During Osteogenesis Hai Wu*, Jonathan Gordon, Troy Whitfield, Seungchan Yang, Jason Dobson, Phillip Tai, Andre Van Wijnen, Janet Stein, Jane Lian, Gary Stein. University of Massachusetts Medical School, USA Disclosures: Hai Wu, None

MO0241

Global Transcriptome Analysis of Osteoblasts in Transgenic Models of Manipulated G Protein Signaling Lalita Wattanachanya*1, Susan M. Millard2, Weidar Lu1, Dylan O’Carroll1, Peter Mailhot1, Edward Hsiao3, Bruce R. Conklin4, Robert Nissenson 1. 1VA Medical Center & University of California, San Francisco, USA, 2University of Queensland, Australia, 3 University of California, San Francisco, USA, 4Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, USA Disclosures: Lalita Wattanachanya, None

MO0242

Increased Expression of Thrombospondin 1 in Runx2 Transgenic Mice Guillaume de la Houssaye*, Valerie Geoffroy. INSERM Unit 606, France Disclosures: Guillaume de la Houssaye, None

MO0243

Interaction of Prx-1 with Runx2 Suppresses Osterix Transcription Linda Gilbert1, Xanghuai Lu2, Hong Chen 2, Mark Nanes*3. 1VA Medical Center, USA, 2 Emory University, USA, 3VA Medical Center & Emory University, USA Disclosures: Mark Nanes, None

250

MO0244

Interactions between ERK1/2 and p38 MAP Kinase Pathways Control RUNX2 Phosphorylation and Transcriptional Activity Chunxi Ge* 1, Qian Yang1, Guisheng Zhao1, Hong Yu2, Keith Kirkwood3, Renny Franceschi4. 1University of Michigan School of Dentistry, USA, 2Department of Craniofacial Biology, Medical University of South Carolina, USA, 3Medical University of South Carolina, USA, 4Dept of Periodontics & Oral Medicine, University of Michigan School of Dentistry, USA Disclosures: Chunxi Ge, None

MO0245

Mechanism of Akt and Erk Activation in Mechanically-stimulated Osteoblasts: Cross-talk Between Calcium and cGMP Hema Rangaswami*1, Raphaela Schwappacher2, Nisha Marathe2, Darren Casteel2, Sanford Shattil2, Gerry Boss2, Renate Pilz 2. 1University of California, San Diego, USA, 2 UCSD, USA Disclosures: Hema Rangaswami, None

MO0246

Withdrawn

MO0247

Protein Inhibitors of Activated STAT (PIAS) Proteins Regulate Runx2 Transactivation Activity Masataka Nakamura, Noriko Funato*. Tokyo Medical & Dental University, Japan Disclosures: Noriko Funato, None

MO0248

Sclerostin Expression Is Induced by BMPs in Human Saos-2 Osteosarcoma Cells but Not Through Direct Effects on Its Promoter or ECR5 Element Longchuan Yu*, Marissa van der Valk, Jin Cao, Chun-Ya E. Han, Todd Juan, Michael B. Bass, Chetan Deshpande, Michael A. Damore, Richard Stanton, Philip Babij. Amgen, Inc., USA Disclosures: Longchuan Yu, Amgen, Inc., 1

MO0249

Statin Suppresses Excess Runx2 Expression in Human Osteoblastic Osteosarcoma Cells Takashi Ikeo*1, Aiko Kamada1, Yoshihiro Yoshikawa1, Eisuke Domae1, Seiji Goda1, Isao Tamura1, Yoshitomo Takaishi2, Takuo Fujita3. 1Osaka Dental University, Japan, 2 Takaishi Dental Clinic, Japan, 3Katsuragi Hospital, Japan Disclosures: Takashi Ikeo, None

OSTEOBLASTS: HORMONAL REGULATION AND SIGNAL TRANSDUCTION MO0250

ATP stimulates Caveolar Endocytosis of P2X7 Receptors in MC3T3-E1 Osteoblasts Vimal Gangadharan*, Anja Nohe, Randall Duncan. University of Delaware, USA Disclosures: Vimal Gangadharan, None

MO0251

Ga11 Over-expression in Osteoblasts of Growing Mice Results in Osteopenia Ariana Dela Cruz*1, Michael Mattocks1, Kim Sugamori1, Marc Grynpas2, Jane Mitchell1. 1 University of Toronto, Canada, 2Samuel Lunenfeld Research Institute, Canada

MO0252

Insulin Resistance Takes Place in Bone of Type 2 Diabetic Mice. Jianwen Wei*, Mathieu Ferron, Patricia Ducy, Gerard Karsenty. Columbia University, USA Disclosures: Jianwen Wei, None

MO0253

Phospholipase Cgamma1 and Inositol Hexakisphosphate Kinase 1/2 are Required for the Cx43-dependent Amplification of the Osteoblast Response to FGF2 Corinne Niger, Maria Luciotti, Joseph Stains*. University of Maryland School of Medicine, USA Disclosures: Joseph Stains, None

MO0254

Serum Osteocalcin Is Not Associated with Energy Expenditure or Glucose Metabolism In a Cohort of Low and High Fatness Families Sulin Cheng*1, Kaisa K. Ivaska2, Leiting Xu3, Kalervo H. Va¨a¨na¨nen 2, The Calex-family study group4. 1University of Jyva¨skyla¨, Finland, 2Department of Cell Biology & Anatomy, Institute of Biomedicine, University of Turku, Finland, 3University of Jyvaskyla, Finland, 4 Department of Health Sciences, University of Jyva¨skyla¨, Finland Disclosures: Sulin Cheng, None

251

Monday

Disclosures: Ariana Dela Cruz, None

MO0255

The Protein Kinase Inhibitor (PKI) Gene Family Decreases Osteoblast Differentiation by Terminating Protein Kinase A (PKA) Signaling Edward Greenfield 1, Guang Zhou1, Shunichi Murakami1, Guangbin Luo1, Janet Rubin2, Erik Schnaser1, Bryan Hausman1, Xin Chen*1. 1Case Western Reserve University, USA, 2 University of North Carolina, Chapel Hill, School of Medicine, USA Disclosures: Xin Chen, None

OSTEOBLASTS: PROGENITOR AND STROMAL CELLS, PROLIFERATION AND DIFFERENTIATION MO0256

A Comparison of Murine Long Bone Segmental Defect Repair Models Liping Wang*1, Xi Jiang1, Nathan Dyment2, Aditya Chaubey2, David Butler2, David Rowe1. 1University of Connecticut Health Center, USA, 2University of Cincinnati, USA Disclosures: Liping Wang, None

MO0257

Copper Stimulated Differentiation of Mesenchymal Stem Cells Ines Burghardt1, Frank Lu¨then1, Cornelia Prinz2, Hans-Georg Neumann2, Joachim Rychly*1. 1University of Rostock, Germany, 2DOT GmbH, Germany Disclosures: Joachim Rychly, None

MO0258

Dietary Amino Acids Activate the MAPK Pathway In Bone Marrow Stromal Cells Ke-Hong Ding*1, Qing Zhong1, Xing-Ming Shi2, Wendy Bollag 1, Michael Cain1, Clare Bergson1, Erin Fynan1, William Hill 1, Mona ElRefaey1, Karl Insogna3, Norman Chutkan 1, Monte Hunter1, Mark Hamrick1, Carlos Isales2. 1Georgia Health Sciences University, USA, 2Medical College of Georgia, USA, 3Yale University School of Medicine, USA Disclosures: Ke-Hong Ding, None

MO0259

Ebf1: An Essential Regulator of Mesenchymal Lineage Allocation and Osteoblast Differentiation Jackie Fretz*1, Tracy Nelson2, Mark Horowitz2. 1Yale School of Medicine, USA, 2Yale University School of Medicine, USA Disclosures: Jackie Fretz, None

MO0260

Ectonucleotide Pyrophosphate/Phosphodiesterase-1 (Enpp1) Promotes Osteoblast Differentiation Through a Catalytic Independent Mechanism Hwa Kyung Nam, Jin Liu, Nan Hatch*. University of Michigan, USA Disclosures: Nan Hatch, None

MO0261

Effects of Rosiglitazone on Circulating Osteoblast and Osteoclast Cell Populations in Postmenopausal Women With Type 2 Diabetes Mellitus Mishaela Rubin1, John Sanil Manavalan1, Donald McMahon2, Antonio Nino 3, Allison Northcutt 4, Barbara Kravitz5, Paul Gitanjali5, Lorraine Fitzpatrick4, John Bilezikian*2. 1 Columbia University, USA, 2Columbia University College of Physicians & Surgeons, USA, 3GSK, USA, 4GlaxoSmithKline, USA, 5GlaxosmithKline Pharmaceuticals, USA Disclosures: John Bilezikian, GSK, 2

MO0262

Epigenetic Control of Fetal Bone Development through HoxA10 in the Rat Jin-Ran Chen*1, Jian Zhang1, Oxana P. Lazarenko1, Rebecca A. Wynne2, Michael L. Blackburn1, Martin J. Ronis1, Kartik Shankar1, Thomas M. Badger1. 1University of Arkansas for Medical Science, Arkansas Children’s Nutrition Center, USA, 2ACNC, USA Disclosures: Jin-Ran Chen, None

MO0263

Epigenetic Regulation of Human Mesenchymal Stem Cell Differentiation by CyclinDependent Kinase-9 and the Histone H2B Ubiquitin Ligase RNF40 Oleksandra Karpiuk*1, Andrei Shchebet1, Zeynab Najafova 1, Moustapha Kassem2, Steven Johnsen 1. 1Georg-August University, Dept. of Molecular Oncology, Germany, 2Odense University Hospital, Denmark Disclosures: Oleksandra Karpiuk, None

252

MO0264

Identification of the Differentially Methylated Promoter and Intragenic CpG-Cytosines in the Human Synovium and Bone Marrow Derived Mesenchymal Stem Cells Yoichi Ezura*1, Tadayoshi Hayata2, Tetsuya Nakamoto 3, Takuya Notomi4, Ichiro Sekiya3, Takeshi Muneta3, Masaki Noda3. 1Tokyo Medical & Dental University, Medical Research Insititute, Japan, 2Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Japan, 4GCOE, Tokyo Medical & Dental University, Japan Disclosures: Yoichi Ezura, None

MO0265

Interleukin-3 Promotes Osteoblast Differentiation and Bone Formation of Human Mesenchymal Stem Cells Amruta P. Barhanpurkar 1, Navita Gupta1, Rupesh K. Srivastava 1, Geetanjali B. Tomar2, Sameer P. Naik1, Satish T. Pote 1, Gyan C. Mishra1, Mohan Wani*1. 1National Centre for Cell Science, India, 2National Center for Cell Science, India Disclosures: Mohan Wani, None

MO0266

Involvement of Changes in Subcellular Localization of Runx2 and Osterix in Osteoblast Differentiation Revealed by 3-dimensional Fluorescence Morphometry Takashi Watanabe* 1, Ayako Nakane1, Akiyoshi Hoshino2, Yuji Makino3, Akira Yamaguchi 4, Tadahiro Iimura1. 1Tokyo Medical & Dental University, Global Center of Excellence Program, Japan, 2National Center for Global Health & Medicine, Japan, 3 Juntendo University Graduate School of Medicine, Department of Orthopedic Surgery, Japan, 4Tokyo Medical & Dental University, Japan Disclosures: Takashi Watanabe, None

MO0267

MAN-1, a Novel Target to Stimulate Osteoblastogenesis and Bone Formation Christopher Vidal*1, Jessica Tong2, Lee Wei Li 3, Li Sze Yeo 4, Diane Fatkin2, Gustavo Duque5. 1University of Sydney, Australia, 2Faculty of Medicine, University of New South Wales, Australia, 3University of Sydney, Nepean Clinical School, Australia, 4Victor Chang Cardiac Research Institute, Australia, 5Ageing Bone Research Program, University of Sydney, Australia Disclosures: Christopher Vidal, None

MO0268

Osteogenic Differentiation in Adipose Tissue Mesenchymal Stem Cells: Effect of Strontium Ion Sergio Fabbri, Valeria Nardone, Simone Ciuffi, Francesca Marini, Gianna Galli, Carmelo Mavilia, Roberto Zonefrati, Anna Maria Carossino, Annalisa Tanini, Maria Luisa Brandi*. University of Florence, Italy Disclosures: Maria Luisa Brandi, None

MO0269

p53 is Required for TNFa to Inhibit Osteoblast Proliferation and Differentiation Nicole Fleming1, Decorian Williams1, Christine Eischen1, Charles Lumpkin2, Daniel Perrien* 3. 1Vanderbilt University, USA, 2University of Arkansas for Medical Sciences, USA, 3Vanderbilt University Medical Center, USA

MO0270

Thyroid Hormone Antagonist NH3 Inhibits Osteoblast Differentiation in Human Calvaria Periosteal Mesenchymal Stem Cell Cristiane Costa*1, Roberto Fanganiello2, Thomas Scanlan3, Maria Rita Passos-Bueno 4, Cecilia Gouveia5. 1Institute of Biomedical Science, Brazil, 2Institute of Biosciences, University of Sao Paulo, Brazil, Brazil, 3Oregon Health & Science University, USA, 4 Institute of Bioscience, University of Sao Paulo, Brazil, 5University of Sao Paulo, Institute of Biomedical Sciences, Brazil Disclosures: Cristiane Costa, None

253

Monday

Disclosures: Daniel Perrien, None

OSTEOCLASTS: CATHEPSINS AND OTHER PROTEINASES MO0271

Human And Mouse Osteoclastogenesis Are Inhibited By Cysteine Proteinase Inhibitors Through Interference With Rank Signaling Fredrik Stralberg*1, Petra Henning2, Inger Gjertsson3, Pedro Souza4, Magnus Abrahamson5, Franciszek Kasprzykowski6, Anders Grubb7, Ulf Lerner8. 1Molecular Periodontology, Umea˚ University, Sweden, 2CENTRE FOR BONE & ARTHRITIS RESEARCH, Sweden, 3Department of Rheumatology & Inflammation Research, Go¨teborg University, Sweden, 4Department of Physiology & Pathology, Sao Paulo State University, Brazil, 5Laboratory Medicine, Division of Clinical Chemistry & Pharmacology, Lund University, Sweden, 6Department of Organic Chemistry, University of Gdansk, Poland, 7Clinical Chemistry & Farmacology, Sweden, 8University of Umea, Sweden Disclosures: Fredrik Stralberg, None

OSTEOCLASTS: CELL ADHESION MO0272

Lyn and other Src-family Tyrosine Kinases cannot rescue the cytoskeletal phonotype of Src-/Osteoclasts Takuma Matsubara*1, Lynn Neff2, William Horne2, Roland Baron3. 1Oral Medicine, Infection & Immunity Harvard School of Dental Medicine, USA, 2Harvard School of Dental Medicine, USA, 3Harvard School of Medicine & of Dental Medicine, USA Disclosures: Takuma Matsubara, None

MO0273

The activity of Dock5, an Osteoclast Specific Activator of the GTPase Rac, is Necessary for the Endochondral Ossification of Mouse Bones. He´iani Touaitahuata1, Gaelle Cres 2, Anne Blangy*1. 1CNRS UMR 5237 CRBM, France, 2 Centre De Recherche De Biochimie Macromole´culaire, France Disclosures: Anne Blangy, None

OSTEOCLASTS: CYTOKINES AND GROWTH FACTORS MO0274

Cytokine Release and Osteoclast Formation from Peripheral Blood Mononuclear Cells from Patients With Chronic Periodontitis Bruno Herrera*1, Alliny Souza Bastos1, Leila Santana Coimbra1, Simone Aparecida Teixeira2, Marcelo Nicolas Muscara2, Luis Carlos Spolidorio1. 1Department of Physiology & Pathology, Araraquara Dental School, UNESP, Brazil, 2Department of Pharmacology, Intitute of Biomedical Sciences, USP, Brazil Disclosures: Bruno Herrera, None

MO0275

IL-17A and IL-17F, but not IL-17B-E, Stimulate Bone Resorption in Mouse Calvarial Bones by Enhancing RANKL. Pedro P. C. Souza*1, Catharina Lindholm2, Howard Conaway3, Ulf Lerner4. 1Sao Paulo State University, Brazil, 2Center for Bone Research, Sweden, 3University of Arkansas for Medical Sciences, USA, 4University of Umea, Sweden Disclosures: Pedro P. C. Souza, None

MO0276

Osteoprotegerin Prevents Infection-induced Bone Loss Yasunari Takada*, Koichi Matsuo. School of Medicine, Keio University, Japan Disclosures: Yasunari Takada, None

MO0277

TGF-b Represses S1P Production in Osteoclasts to Reduce Osteoblast Recruitment Kuniaki Ota*1, Patrick Quint2, Moustapha Kassem3, Jennifer Westendorf1, Sundeep Khosla4, Merry Jo Oursler1. 1Mayo Clinic, USA, 2Mayo Clinic Rochester, USA, 3Odense University Hospital, Denmark, 4College of Medicine, Mayo Clinic, USA Disclosures: Kuniaki Ota, None

MO0278

TNF-alpha Induces RANKL Expression in Gingival Epithelium through PKA Signaling Michihiko Usui*, Ryoichi Fujihara, Akiko Yano, Akihiro Saito, Matsuo Yamamoto. Showa University School of Dentistry, Japan Disclosures: Michihiko Usui, None

254

OSTEOCLASTS: DIFFERENTIATION MO0279

In Vivo Migration of Osteoclast Progenitors to the Bone Marrow and Peripheral Tissues in a Competitive Reconstitution Mouse Model. Christian Jacome*, Sun-Kyeong Lee, Joseph Lorenzo, Hector Aguila. University of Connecticut Health Center, USA Disclosures: Christian Jacome, None

MO0280

In Vitro Osteoclastogenesis is Impaired in Cells from +/R740S Osteopetrotic Mice Irina Voronov*1, Noelle Ochotny1, Celeste Owen2, Morris Manolson3, Jane Aubin4. 1 University of Toronto, Canada, 2Centre for Modeling Human Disease, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Canada, 3University of Toronto, Can, 4University of Toronto Faculty of Medicine, Canada Disclosures: Irina Voronov, None

MO0281

DR3 and TL1A – Effect on Osteoclast Differentiation and Function Eddie Wang, Anwen Williams, Fraser Collins*, Anja Bloom. Cardiff University, United Kingdom Disclosures: Fraser Collins, None

MO0282

Epigenetic Regulation of Osteoclast Differentiation: Possible Involvement of Jmjd3 in the Histone Demethylation of Nfatc1 Jun Hirose*1, Tetsuro Yasui2, Takumi Matsumoto3, Hironari Masuda4, Kozo Nakamura3, Sakae Tanaka3. 1The University of Tokyo, Japan, 2University of Tokyo, Japan, 3The University of Tokyo, Japan, 4The University of Tokyo, Jpn Disclosures: Jun Hirose, None

MO0283

Evidence that ITAM Related Factors in Synovial Tissue and Vasculature of Active Rheumatoid Arthritis may be Involved in Modulating Local Bone Erosion Tania Crotti* 1, Ekram Alias 2, Kencana Dharmapatni 2, Helen Weedon3, Andrew Zannettino 4, Malcolm Smith5, David Haynes6. 1University of Adelaide, Australia, 2 Discipline of Anatomy & Pathology, University of Adelaide, Australia, 3Rheumatology Unit, Repatriation General Hospital, Flinders University, Australia, 4Myeloma Research Laboratory, Centre for Cancer Biology, SA Pathology & Department of Medicine, University of Adelaide, Australia, 5Rheumatology Research Unit, Repatriation General Hospital, Flinders University, Australia, 6Discipline of Anatomy & Pathology, School of Medical Sciences, Australia Disclosures: Tania Crotti, None

MO0284

Disclosures: Guy Yoskovitz, None MO0285

Gamma-Radiation Causes Trabecular Bone Loss Similar to Skeletal Aging and Stimulates Resorptive Activity In Vitro Joshua Alwood*1, Akhilesh Kumar1, Luan Tran1, Angela Wang1, Charles Limoli2, Ruth Globus1. 1NASA Ames Research Center, USA, 2UC Irvine, USA Disclosures: Joshua Alwood, None

MO0286

Hypoxia-Related Regulation of Osteoclast Formation by Pyruvate Kinase M2 Youngho Kim1, Lexie Holliday2, Edgardo Toro3, SEONG SIK KIM*4. 1Department of Orthodontics, School of Dentistry, Pusan National University, South Korea, 2University of Florida College of Dentistry, USA, 3University of Florida, USA, 4Pusan National University, South Korea Disclosures: SEONG SIK KIM, None

255

Monday

Functional Study of the RANKL Promoter Regions and the Effect of Hormone and Cytokine Treatments Guy Yoskovitz*1, Natalia Garcia-Giralt1, Roberto Gu¨erri 1, Daniel Prieto-Alhambra1, Patricia Sarrion2, Roser Urreizti2, Leonardo Mellibovsky 1, Luis Perez-Edo3, Susana Balcells2, Daniel Grinberg2, Adolfo Diez-Perez 1, Xavier Nogues1. 1URFOA, IMIM, RETICEF, Hospital del Mar, Autonomous University of Barcelona, Spain, 2Genetics Dept, University of Barcelona, CIBERER, IBUB, Barcelona, Spain, 3Hospital Ntra Sra Del Mar, Spain

MO0287

Identification and Isolation of Transplantable Osteoclast Progenitors from Human Pluripotent Stem Cells Sierra Root*, Hector Aguila. University of Connecticut Health Center, USA Disclosures: Sierra Root, None

MO0288

Identification of the Promoter Region that Mediates Colony Stimulating Factor 1 Induction of the Jun Dimerization Protein 2 Gene Gang-Qing Yao*, Karl Insogna. Yale University School of Medicine, USA Disclosures: Gang-Qing Yao, None

MO0289

M-CSF Induces Osteoclastogenesis Resistance In CD31+/Ly6C+ Osteoclast Precursors; An Effect Not Occurring In the Presence of Bone Teun De Vries1, Ton Schoenmaker2, Pieter J.M. Leenen3, Vincent Everts* 4. 1ACTA, University of Amsterdam & VU University, The Netherlands, 2Dept Periodontology, ACTA, Netherlands, 3Dept. Immunology, Erasmuc MC, Netherlands, 4ACTA, Vrije Universiteit, The Netherlands Disclosures: Vincent Everts, None

MO0290

PAMM Expression During Osteoclastogenesis Is Mediated by Akt Activation Li Zhang1, Liang Ye2, Leslie Morse3, Raquel Silva4, Yan Xu5, Ricardo Battaglino*1. 1The Forsyth Institute, USA, 2Harvard School of Dental Medicine, USA, 3Harvard Medical School, USA, 4School of Dentistry of Ribeira˜o Preto - University of Sa˜o Paulo, Brazil, 5 Kunming Medical University, China Disclosures: Ricardo Battaglino, None

MO0291

Potent Inhibitory Effect of Foeniculum Vulgare Miller Extract on Osteoclast Differentiation and Ovariectomy-Induced Bone Loss Tae-Ho Kim*1, Eui Kyun Park2, Hyun-Ju Kim1, Sang-Han Lee3, Shin-Yoon Kim4. 1 Kyungpook National University School of Medicine, South Korea, 2Kyungpook National University School of Dentistry, South Korea, 3eDepartment of Food Science & Biotechnology, Kyungpook National Univ., South Korea, 4Kyungpook National University Hospital, South Korea Disclosures: Tae-Ho Kim, None

MO0292

The CorningH Osteo Assay Surface for Osteoclast Differentiation and Bone Resorption A Fawad Faruqi*. Corning Life Sciences, USA Disclosures: A Fawad Faruqi, None

MO0293

Two RANK TRAF-binding Motifs Play a Pivotal Role in TNF- and IL-1-mediated Osteoclastogenesis via functional crosstalk with the IVVY motif in the RANK Cytoplasmic Domain Joel Jules*, Zhenqi Shi, Jianzhong Liu, Shi Wei, Xu Feng. University of Alabama at Birmingham, USA Disclosures: Joel Jules, None

OSTEOCLASTS: INHIBITION OF RESORPTION MO0294

A Computational Model to Examine Osteocytes’ Potential to Regulate Osteoclastic Resorption Lyndsey Schutte*, Jeffrey Hollinger. Carnegie Mellon University, USA Disclosures: Lyndsey Schutte, None

MO0295

Effect of Rac GTPase Deletion on Osteoclast Cytoskeletal Organization Monica Croke*1, Wei Zou2, Steven Teitelbaum2. 1Washington University School of Medicine, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Monica Croke, None

MO0296

Functional Involvement of the Microtubule-Binding Dynein-Dynactin Complex in Osteoclast Formation and Bone Resorption Pei Ying Ng*1, Haotian Feng2, Ee Cheng Khor1, Shiqiao Ye 3, Haibo Zhao3, Ming Hao Zheng2, Jiake Xu1, Nathan Pavlos1. 1The University of Western Australia, Australia, 2 University of Western Australia, Australia, 3University of Arkansas for Medical Sciences, USA Disclosures: Pei Ying Ng, None

256

MO0297

Oligomerization of the Osteoclastic Chloride Transporter ClC-7 Demonstrated by Bioluminescence Resonance Energy Transfer (BRET) Vicki Jensen*, Morten Karsdal, Kim Henriksen. Nordic Bioscience A/S, Denmark Disclosures: Vicki Jensen, None

MO0298

Osthole Inhibits Osteoclastogenesis through Activation of b-Catenin-OPG Signaling De-Zhi Tang*1, Zhou Yang1, Qi Shi 1, Di Chen2, Yong-Jun Wang1. 1Spine Research Institute, Shanghai University of Traditional Chinese Medicine, China, 2University of Rochester Medical Center, USA Disclosures: De-Zhi Tang, None

MO0299

Polarized Osteoclasts Put Marks of Tartrate-Resistant Acid Phosphatase on Dentin Slices-A Simple Method for Identifying Polarized Osteoclasts Nakayama TAKAHIRO*1, Mizoguchi Toshihide2, Uehara Shunsuke2, Yamashita Teruhito2, Kawahara Ichiro2, Kobayashi Yasuhiro 2, Udagawa Nobuyuki2, Takahashi Naoyuki 2. 1Matsumoto Dental University, Japan, 2Matumoto Dental University, Japan Disclosures: Nakayama TAKAHIRO, None

MO0300

Protein Kinase C-d Regulates Osteoclastic Bone Resorption Ee Cheng Khor*1, Tamara Abel2, Jennifer Tickner2, Taksum Cheng2, Keiichi Nakayama3, Keiko Nakayama 4, Nathan Pavlos1, Ming Hao Zheng2, Jiake Xu1. 1The University of Western Australia, Australia, 2University of Western Australia, Australia, 3Kyushu University, Japan, 4Tohoku University Graduate School of Medicine, Japan Disclosures: Ee Cheng Khor, None

MO0301

Versatile Roles of V-ATPase Accessory Subunit Ac45 in Osteoclast Formation and Function An Qin1, Taksum Cheng2, Ke Rong Dai3, Ming Hao Zheng*4, Qing Jiang5, Nathan Pavlos2, Jiake Xu2. 1Shanghai Jiao Tong University; The University of Western Australia, Australia, 2The University of Western Australia, Australia, 3Shanghai Jiao Tong University, China, 4University of Western Australia, Australia, 5Nanjing University, China Disclosures: Ming Hao Zheng, None

MO0302

a-tocotrienol Inhibits Osteoclastic Bone Resorption by Suppressing RANKL Expression and Signaling and Bone Resorbing Activity Hyunil Ha1, Jong-Ho Lee 2, Ha-Neui Kim 1, Jung-Wook Kim3, Zang Hee Lee*4. 1Seoul National University, South Korea, 2Department of Cell & Developmental Biology, School of Dentistry, Seoul National University, South Korea, 3Department of Pediatric Dentistry, School of Dentistry, Seoul National University, South Korea, 4Seoul National University School of Dentistry, South Korea Disclosures: Zang Hee Lee, None

OSTEOCLASTS: SIGNAL TRANSDUCTION MO0303

Disclosures: Masahiro Shinohara, None MO0304

Osteopontin Signals through Calcium-NFAT in Osteoclasts: A Novel RGD-dependent Pathway Promoting Cell Survival Natsuko Tanabe*1, Benjamin D Wheal2, Ryan Shugg2, Hong H Chen2, Stephen M Sims2, Harvey Goldberg3, S. Jeffrey Dixon2. 1Nihon University School of Dentistry, Japan, 2The University of Western Ontario, Canada, 3University of Western Ontario, Canada Disclosures: Natsuko Tanabe, None

MO0305

Poly-ubiquitination of NF-kB Pathway Mediates Inflammatory Osteolysis Kannan Karuppaiah, Yousef Abu-Amer*. Washington University in St. Louis School of Medicine, USA Disclosures: Yousef Abu-Amer, None

MO0306

RANK Regulates the Osteoclast Cytoskeleton in a c-Src/avb3 Dependent Manner Takashi Izawa*1, Wei Zou2, Steven Teitelbaum2. 1Washington University in St. Louis, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Takashi Izawa, None

257

Monday

Class IA Phosphatidylinositol 3-kinase Regulates Osteoclastic Bone Resorption Masahiro Shinohara*1, Sakae Tanaka2, Hiroshi Takayanagi 3. 1Tokyo Medical & Dental University, Jpn, 2The University of Tokyo, Japan, 3Tokyo Medical & Dental University, Japan

OSTEOCYTES: REGULATION OF BONE FORMATION MO0307

Assessment of the GPCR Landscape in Osteocytes Reveals Novel Candidate Regulators of Bone Homeostasis Christine Halleux*1, Frederic Bassilana2, Ina Kramer1, Hansjoerg Keller1, Frederic Morvan1, Olivier Leupin1, Klaus Seuwen1, Michaela Kneissel1. 1Novartis Institutes for Biomedical Research, Switzerland, 2Novartis Instutes for Biomedical Research, Switzerland Disclosures: Christine Halleux, None

MO0308

CSF-1 Deficiency in CSF-1KO Mice Leads to Osteocyte Defects Sherry Abboud Werner* 1, Diane Horn2, Kathleen Woodruff2, Rekha Kar3, Xiaodu Wang4, Jean Jiang1, Marie Harris1, Stephen Harris1. 1University of Texas Health Science Center at San Antonio, USA, 2University of Texas Health Science Center, USA, 3The University of Texas Health Science Center, USA, 4University of Texas at San Antonio, USA Disclosures: Sherry Abboud Werner, None

MO0309

Effects of Pioglitazone on Serum Levels of Sclerostin and Bone Turnover Markers in Male Patients with Type 2 Diabetes Mellitus Antoon Van Lierop*1, Neveen Hamdy1, Rutger van der Meer2, Jacqueline Jonker2, Michaela Diamant3, Luuk Rijzewijk 3, A de Roos2, Johannes Romijn4, Jan Smit2, Socrates Papapoulos 1. 1Leiden University Medical Center, The Netherlands, 2Leiden University Medical Center, Netherlands, 3VU University Medical Center, Netherlands, 4Amsterdam Medical Center, Netherlands Disclosures: Antoon Van Lierop, None

MO0310

IL-6 Affects Signaling Molecule Production by Osteocytes Resulting in Inhibition of Osteoblast Differentiation Astrid D Bakker*1, Rishikesh N Kulkarni1, Willem F Lems 2, Jenneke Klein-Nulend 1. 1 ACTA - University of Amsterdam & VU University Amsterdam, Research Institute MOVE, Netherlands, 2VU University Medical Center, Research Institute MOVE, Netherlands Disclosures: Astrid D Bakker, None

MO0311

Responses of Osteocytes to Microdamage in vitro Chao Liu*1, Lidan You2. 1University of Toronto, Canada, 2Mechanical & Industrial Engineering, University of Toronto, Canada Disclosures: Chao Liu, None

MO0312

Sclerostin Antibody Enhances Bone Repair in a Rat Femoral Defect Model Farhang Alaee*1, Amy Tang1, Michael Ominsky2, Hua Zhu Ke3, Marina Stolina4, Denise Dwyer5, Jay Lieberman1. 1University of Connecticut Health Center, USA, 2Amgen, Incorporated, USA, 3Amgen, Inc., USA, 4Amgen Inc, USA, 5Amgen Inc., USA Disclosures: Farhang Alaee, None

MO0313

The Isolation and Culture of Primary Osteocytes from the Long Bones of Skeletally Mature and Aged Mice Amber Stern*1, Matthew Stern2, Mark Van Dyke3, Lynda Bonewald1. 1University of Missouri - Kansas City, USA, 2University of Missouri-Kansas City, USA, 3Wake Forest University, USA Disclosures: Amber Stern, None

MO0314

Ultrastructural Evidence for Continued Synthetic Activity in Osteocytes Ruairidh, I. Watson1, Eman Azzam1, Jenny, S. Gregory1, Miep Helfrich*2. 1 Musculoskeletal Programme, School of Medicine & Dentistry, University of Aberdeen, United Kingdom, 2University of Aberdeen, United Kingdom Disclosures: Miep Helfrich, None

OSTEOCYTES: REGULATION OF BONE MINERALIZATION MO0315

Histochemical Examination on the Distribution of DMP-1, MGP and Osteocalcin in Klotho-/Mice Muneteru Sasaki*1, Chihiro Tabata1, Tomoka Hasegawa1, Minqi Li 1, Tsuneyuki Yamamoto1, Nobuo Inoue1, Norio Amizuka2. 1Hokkaido University, Japan, 2Hokkaido University School of Dentistry, Japan Disclosures: Muneteru Sasaki, None

258

OSTEOCYTES: REGULATION OF MINERAL ION HOMEOSTASIS MO0316

1,25(OH)2D and PTH Up-regulate Rankl while Down-regulate Phex and Dmp1 in Primary Osteocytes Isolated from Mouse Bones. Kazuaki Miyagawa*1, Keiichi Ozono2, Kanako Tachikawa 1, Masanobu Kawai1, Yuko Mikuni-Takagaki3, Mikihiko Kogo4, Toshimi Michigami1. 1Department of Bone & Mineral Research, Osaka Medical Center & Research Institute for Maternal & Child Health, Japan, 2Osaka University Graduate School of Medicine, Japan, 3Kanagawa Dental College & Graduate School of Dentistry, Japan, 4Osaka University Graduate School of Dentistry, Japan Disclosures: Kazuaki Miyagawa, None

MO0317

Characteristics of Osteocyte Lacunae in Patients with Renal Hyperparathyroidism Aiji Yajima*1, Shigeru Satoh2, Yoshihiro Tominaga 3, Shigeru Otsubo4, Masaaki Inaba5, Kosaku Nitta6, Akemi Ito7. 1Towa Hospital, Japan, 2Division of Renal Replacement Therapeutic Science, Akita University School of Medicine, Japan, 3Department of Transplant Surgery, Nagoya Second Red Cross Hospital, Japan, 4Department of Nephrology, Sangenjyaya Hospital, Japan, 5Department of Internal Medicine, Metabolism, Endocrilogy & Molecular Medicine, Osaka City University Graduate School of Medicine, Japan, 6Department of Medicine, Kidney Center, Tokyo Women’s Medical University, Japan, 7Ito Bone Histomorphometry Institute, Japan Disclosures: Aiji Yajima, Chugai, 5

MO0318

Menopause-related Changes in Osteocyte Lacunar Density, Volume, and Separation in Adult Human Trabecular Bone Mohammed Akhter* 1, Robert Recker1, Tiffany Fong2, Donald Kimmel3. 1Creighton University Osteoporosis Research Center, USA, 2Xradia, Inc., USA, 3Kimmel Consulting Services, USA Disclosures: Mohammed Akhter, Xradia, Inc., 5

MO0319

Skeletal Unloading Changes Phosphate (Pi) Homeostasis Rong Zhang*1, X Han2, Baozhi Yuan3, Marc Drezner 4, Lynda Bonewald5, Jian Feng6. 1 School of Stomatology,Fourth Military Medical University, Peoples Republic of China, 2 Baylor College of Dentistry, USA, 3University of Wisconsin, Madison, USA, 4University of Wisconsin, USA, 5University of Missouri - Kansas City, USA, 6Texas A&M Health Science Center, USA Disclosures: Rong Zhang, None

OSTEOPOROSIS ASSESSMENT: BIOCHEMICAL MARKERS MO0320

A New Sandwich ELISA of Mouse Periostin for in-vitro and in-vivo Animal Studies Jean-Charles Rousseau*1, Marjorie Thomas2, Blandine Merle1, Cindy Bertholon1, Olivier Borel1, Evelyne Gineyts1, Patrick Garnero3. 1INSERM UMR 1033, Universite´ de Lyon, France, 2INSERM UMR1 033, Universite´ de Lyon, France, 3INSERM UMR 1033, Universite´ de Lyon & Cisbio Bioassays, France

MO0321

Correlations of Urinary 41Ca with Biomarkers and Minerals in Post-Menopausal Women George Jackson*, WangHee Lee, Berdine Martin, Connie Weaver. Purdue University, USA Disclosures: George Jackson, None

MO0322

Effectiveness of Urinary Gamma-Glutamyltransferase as Screening for Osteoporosis Shinya Tanaka*1, Sawako Moriwaki2, Kazuhiro Uenishi3, Nobuo Koinuma4, Kiyoshi Tanaka5, Yoshitaka Ikeda6, Shumpei Niida7. 1Saitama Medical University, Japan, 2 Laboratory of Genomics & Proteomics, National, Japan, 3Laboratory of Physiological Nutrition, Kagawa Nutrition University, Japan, 4Department of Health Administration & Policy, Tohoku University Graduate School of Medicine, Japan, 5Department of Food & Nutrition, Kyoto Women’s University, Japan, 6Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Japan, 7National Center for Geriatrics & Gerontology, Japan Disclosures: Shinya Tanaka, None

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Disclosures: Jean-Charles Rousseau, None

MO0323

Magnesium and Osteoporosis: A Clinical Profile of Hypomagnesaemic Patients Attending a Bone Health Clinic James Mahon*1, Joseph McAndrew2, Lorraine O’ Keeffe2, James Walsh3, Miriam Casey2. 1 St James’s Hospital, Ireland, 2St. James’s Hospital, Ireland, 3Trinity College Dublin, The University of Dublin, Ireland Disclosures: James Mahon, None

MO0324

Serum Osteocalcin and Undercarboxylated Osteocalcin Levels Are Associated with Renal Function and Vascular Complications in Type 2 Diabetes Atsushi Suzuki*1, Junnichi Ishii 2, Sahoko Sekiguchi-Ueda1, Megumi Shibata3, Yasumasa Yoshino1, Shogo Asano4, Fumihiko Kitagawa2, Toshiaki Sakuishi2, Takashi Fujita2, Takashi Ishikawa2, Masaki Makino1, Nobuki Hayakawa1, Mitsuyasu itoh1. 1Fujita Health University Division of Endocrinology, Japan, 2Department of Joint Research Laboratory of Clinical Medicine Fujita Health University, Japan, 3Fujita Health University, Division of Endocrinology, Japan, 4Toyokawa City Hospital, Japan Disclosures: Atsushi Suzuki, None

OSTEOPOROSIS ASSESSMENT: BONE MINERAL DENSITY MO0325

Bone loss in Patients with COPD – 3 years of Follow-up Dorthe Brask-Lindemann*1, Suzanne Cadarette2, Dr. Peter Eskildsen3, Bo Abrahamsen4. 1 Copenhagen University Hospital Køge, Denmark, 2University of Toronto, Canada, 3 Koege Hospital, Denmark, 4Copenhagen University Hospital Gentofte, Denmark Disclosures: Dorthe Brask-Lindemann, None

MO0326

Evaluation of FRAX Analysis in Patients with Glucocorticoid-Induced Osteoporosis of Connective Tissue Diseases(CTD) Ikuko Tanaka*1, Shigenori Tamaki2, Hisaji Oshima3. 1National Center for Geratrics & Gerontology, Japan, 2Nagoya Rheumatology Clinic, Japan, 3Tokyo Medical Center, Japan Disclosures: Ikuko Tanaka, None

MO0327

First Demonstration of Microdamages in Vivo in Computerized Magnified Radiograms of the Dental Alveolar Bone and Their Association with Vertebral Fracture and BMD Yoshitomo Takaishi*1, Aiko Kamada2, Takashi Ikeo2, Takami Miki3, Takuo Fujita4. 1 Takaishi Dental Clinic, Japan, 2Osaka Dental University, Japan, 3Osaka City University Medical School, Japan, 4Katsuragi Hospital, Japan Disclosures: Yoshitomo Takaishi, None

MO0328

Knowledge and Perception of Osteoporosis and Fracture Risk Among Post-Menopausal Canadian Women Alexandra Papaioannou* 1, Suzanne Morin2, Jonathan Adachi3, Alan Bell4, Sidney Feldman5, Heather Frame6, Stephanie Kaiser 7. 1Hamilton Health Sciences, Canada, 2 McGill University Health Centre, Canada, 3St. Joseph’s Hospital, Canada, 4University of Toronto, Canada, 5Baycrest Geriatrics Health Care System, Canada, 6Assiniboine Medical Clinic, Canada, 7Dalhousie University, Canada Disclosures: Alexandra Papaioannou, Novartis, 8; Eli Lilly, 5; Amgen, 8; Amgen, 5; Novartis, 5; Amgen, 2; Warner Chilcott, 5

MO0329

Osteoporosis Intervention Threshold based on BMD versus FRAX Peter Jackuliak1, Eva Lalcikova1, Juraj Payer2, Zdenko Killinger*1. 1University Hospital, Bratislava, Slovakia, 2University Hospital, Ruzinov, Slovakia Disclosures: Zdenko Killinger, None

MO0330

The 3/2 Power of Bone Mineral Apparent Density Xiaohai Wan*1, John Krege2. 1Lilly USA, LLC, USA, 2Eli Lilly & Company, USA Disclosures: Xiaohai Wan, Eli Lilly & Co, 3; Eli Lilly & Co, 1

MO0331

Variability in Screening for Post-menopausal Osteoporosis by Canadian Family Physicians Suzanne Morin*1, Alexandra Papaioannou2, Andre´ Belanger 3, Jacques Brown3, Angela Cheung4, David Hanley5, David Kendler 6, Daniel Ngui7. 1McGill University Health Centre, Canada, 2Hamilton Health Sciences, Canada, 3Laval University, Canada, 4 University Health Network, Canada, 5University of Calgary, Canada, 6Osteoporosis Research Centre, Canada, 7University of British Columbia, Canada Disclosures: Suzanne Morin, Novartis, 5; Novartis, 8; Amgen, 2; Eli Lilly, 5; Amgen, 8; Warner-Chilcott, 5; Amgen, 5

260

OSTEOPOROSIS ASSESSMENT: BONE STRUCTURE MO0332

Abnormal Cortical and Trabecular Parameters in Persons with Epilepsy Alison Pack*1, Rebecca B. Bausell1, Stephanie Boutroy2, Donald McMahon3, Elizabeth Shane3. 1Columbia University, USA, 2Columbia University Medical Center, New York, NY, USA, USA, 3Columbia University College of Physicians & Surgeons, USA Disclosures: Alison Pack, None

MO0333

Estimation of Cortical Density with Clinical CT Graham Treece*, Kenneth Poole, Andrew Gee. University of Cambridge, United Kingdom Disclosures: Graham Treece, None

MO0334

Low BMD Is not Necessarily a Measure of Bone Fragility; The Structural Basis of Areal Bone Mineral Density Ali Ghasem-Zadeh*, Thuy Vu, Qingju Wang, Roger Zebaze, Ego Seeman. Austin Health, University of Melbourne, Australia Disclosures: Ali Ghasem-Zadeh, None

MO0335

The Involvement of Two Forces in Osteoporotic Vertebral Fracture -Pressures of the vertebral rim or disk and their involvement in fish shaped and wedge type fractures. Hitoshi Noguchi1, Sumiaki Okamoto*2, Sumitada Okamoto3, Hiroyuki Suzuki4, Akira Itabashi 5. 1Noguchi hospital, Japan, 2Okamoto Clinic SORF, Japan, 3KS Okamoto Naika, Japan, 4Suzuki Orthodontic Clinic, Japan, 5SCBR, Japan Disclosures: Sumiaki Okamoto, None

MO0336

Ultrashort TE Imaging and Bi-Component Analysis of Bound and Free Water Components in Bovine Cortical Bone - Validation with Sequential Drying Reni Biswas*, Won Bae, Eric Diaz, Christine Chung, Graeme Bydder, Jiang Du. University of California, San Diego, USA Disclosures: Reni Biswas, None

OSTEOPOROSIS ASSESSMENT: ULTRASOUND MO0337

Body Composition and Sex Hormones Differently Influence Quantitative Ultrasound Parameters at Calcaneous and at Phalanxes in Elderly Women Stefano Gonnelli*, Carla Caffarelli, Loredana Tanzilli, Daniela Merlotti, Luigi Gennari, Barbara Lucani, Stella Campagna, Beatrice Franci, Ranuccio Nuti. University of Siena, Italy Disclosures: Stefano Gonnelli, None

MO0338

Disclosures: Zohreh Hamidi, None MO0339

Novel Density Index Method for Osteoporosis Diagnostics at Primary Healthcare Juha To¨yra¨s1, Janne Karjalainen*2, Ossi Riekkinen 2, Heikki Kroger1, Jukka Jurvelin2. 1 Kuopio University Hospital, Finland, 2University of Eastern Finland, Finland Disclosures: Janne Karjalainen, None

OSTEOPOROSIS EPIDEMIOLOGY: BONE MINERAL DENSITY MO0340

Bone Mineral Density Does Not Differ Between Ethnic Groups in Preschool Aged Children Attending Daycares. Thu Trang Pham*, Sarah Finch, Sandra Dell’Elce, Sonia Jean-Philippe, Tom Hazell, Sherry Agellon, Celia Rodd, Catherine Vanstone, Hope Weiler. McGill UniVersity, Canada Disclosures: Thu Trang Pham, None

261

Monday

Correlation between QUS of Phalanx and DXA in Assessment of Bone Structure in Hemodialysed Patients Zohreh Hamidi*1, Dr. Sima Maziar2, Dr. Mitra Mahdavi-Mazdeh2, Dr. Abbas Ali Keshtkar2, Dr. Ghassan Maalouf3, Dr. Bagher Larijani2. 1Endocrinology & Metabolism Reserach Center of Tehran University of Medical Sci, Iran, 2Tehran University of Medical Sciences, Iran, 3St George University Hospital, Lebanon

MO0341

Circulating Sclerostin Levels in a Cohort of Adolescent and Young Adult Women: CrossSectional Associations with Age and Bone Mass Delia Scholes* 1, Laura Ichikawa2, Andrea LaCroix3, Thy Do4, Puneet Arora5, Susan Ott6. 1 Group Health Cooperative Group Health Research Institute, USA, 2Group Health Research Institute, USA, 3Women’s Health Initiative, USA, 4Amgen, Inc., USA, 5Amgen Inc., USA, 6University of Washington Medical Center, USA Disclosures: Delia Scholes, None

MO0342

Effects of Age, Gender and Body Composition on Bone Mineral Density and Vitamin D metabolism Shuanhu Zhou, Nithya Setty, Julie Glowacki, Meryl Leboff*. Brigham & Women’s Hospital, USA Disclosures: Meryl Leboff, None

MO0343

Femoral Volumetric Bone Density and Dimensions in Relation to Serum 25-Hydroxy Vitamin D Levels Among Elderly Men Elizabeth Martin*1, Elizabeth Haney2, Jackie Shannon2, Jane Cauley3, Kristine Ensrud4, Joseph Zmuda3, Eric Orwoll2, Lynn Marshall2. 1OHSU, USA, 2Oregon Health & Science University, USA, 3University of Pittsburgh Graduate School of Public Health, USA, 4 Minneapolis VA Medical Center / University of Minnesota, USA Disclosures: Elizabeth Martin, None

MO0344

Occurrences of Falls in Elderly People within the Domicile Bianca Segantin1, Fabiana Fonseca*2, Manuela Santos1, Thais Sabbag1, Ana Elisa Rosa1, Ursula Karsch1, Roberto Queiroz1. 1PUC - SP, Brazil, 2PUC Sp, Brazil Disclosures: Fabiana Fonseca, None

MO0345

Reduction in Hip Bone Mass in Elderly Women Is More Related to Loss of Cortical Bone Than Trabecular Bone ZhiFeng Yu1, Keenan Brown2, Ben Khoo3, Kun Zhu4, Marie Pollock5, Colin Binns6, Deborah Kerr 6, Vicky Solah6, Amanda Devine7, Richard Prince*5. 1School of Medicine, University of Western Australia, Australia, 2Mindways Software, USA, 3Western Australian Health Department, Australia, 4University of Western Australia, Sir Charles Gairdner Hospital, Australia, 5Sir Charles Gairdner Hospital, Australia, 6Curtin University, Australia, 7Edith Cowan University, Australia Disclosures: Richard Prince, None

MO0346

Risk Factors for Osteoporosis in Greek Male Population George Trovas*. , Greece Disclosures: George Trovas, None

MO0347

The Association of Bone Marrow Fat with Areal and Volumetric Bone Mineral Density Differs by Diabetic Status Yahtyng Sheu*1, Francesca Amati2, Ann Schwartz3, Xiaojuan Li 3, Christine Lee 4, Christopher Gordon5, Bret Goodpaster6, Robert Boudreau6, Joseph Zmuda1, Jane Cauley1. 1University of Pittsburgh Graduate School of Public Health, USA, 2University of Lausanne, Switzerland, 3University of California, San Francisco, USA, 4OHSU, USA, 5 McMaster University, Canada, 6University of Pittsburgh, USA Disclosures: Yahtyng Sheu, None

OSTEOPOROSIS EPIDEMIOLOGY: DIET AND ENVIRONMENTAL FACTORS MO0348

Are Plasma Concentrations of B Vitamins or Homocysteine Associated with Bone Volumetric Density and Size? The Framingham Study Robert McLean*1, Shivani Sahni2, Paul Jacques3, Jacob Selhub4, Kerry Broe5, Mary Bouxsein 6, Douglas Kiel7. 1Hebrew SeniorLife, Harvard Medical School, USA, 2Hebrew SeniorLife, Institute for Aging Research, USA, 3 Jean Mayer U.S. Dept of Agriculture Human Nutrition Research Center on Aging at Tufts University, USA, 4Jean Mayer U.S. Dept of Agriculture Human Nutrition Research Center on Aging at Tufts University, USA, 5 Hebrew Senior Life, USA, 6Beth Israel Deaconess Medical Center, USA, 7Hebrew SeniorLife, USA Disclosures: Robert McLean, None

262

MO0349

Distribution and Determinants of Serum 25-hydroxyvitamin D (25[OH]D) Levels and Change in Serum 25[OH]D Levels in Older Women: Data from the Study of Osteoporotic Fractures Marc Hochberg*1, Li-Yung Lui2, Jane Cauley3, Kristine Ensrud4, Lisa Fredman5, Teresa Hillier6, Erin LeBlanc7, Steven Cummings8. 1University of Maryland School of Medicine, USA, 2California Pacific Medical Center Research Institute, USA, 3University of Pittsburgh Graduate School of Public Health, USA, 4Minneapolis VA Medical Center / University of Minnesota, USA, 5Boston University School of Public Health, USA, 6Kaiser Center for Health Research, USA, 7Oregon Health Sciences University School of Medicine, USA, 8San Francisco Coordinating Center, USA Disclosures: Marc Hochberg, Theralogix LLC, 5; Theralogix LLC, 1

MO0350

Effects of Dietary and Serum Alpha-tocopherol versus Serum Gamma-tocopherol Levels on Bone Turnover Markers among US Postmenopausal Women Maryam Hamidi*1, Paul N Corey2, Valerie Tarasuk2, Angela Cheung3. 1University of Toronto/University Health Network-TGH, Can, 2University of Toronto, Canada, 3 University Health Network, Canada Disclosures: Maryam Hamidi, None

MO0351

Physical Activity Patterns and Preferences in Women with Low Bone Mass Carly Skidmore*1, Michel Saccone1, Nicole Mittmann2, Lora Giangregorio1. 1University of Waterloo, Canada, 2Sunnybrook Health Sciences Centre, Canada Disclosures: Carly Skidmore, None

MO0352

Positive Association of Total Dairy and Milk Intake with Bone Mineral Density (BMD): Results from the Framingham Offspring Study. Shivani Sahni*1, Katherine Tucker2, Douglas Kiel3, Lien Quach4, Virginia Casey4, Marian Hannan5. 1Hebrew SeniorLife, Institute for Aging Research, USA, 2Northeastern University, USA, 3Hebrew SeniorLife, USA, 4Institute for Aging Research, Hebrew SeniorLife, USA, 5HSL Institute for Aging Research & Harvard Medical School, USA Disclosures: Shivani Sahni, None

OSTEOPOROSIS EPIDEMIOLOGY: FRACTURE OUTCOME MO0353

Atypical Humeral Fractures and Bisphosphonate Use. Maria Yavropoulou*1, Andrea Giusti2, Sharita Ramautar1, Sanders Dijkstra3, Neveen Hamdy4, Socrates Papapoulos 4. 1Leiden University Medical Center, Department of Endocrinology & Metabolism, Netherlands, 2Galliera Hospital, Italy, 3Leiden University Medical Center, Department of Orthopedic Surgery, Netherlands, 4Leiden University Medical Center, The Netherlands Disclosures: Maria Yavropoulou, None

MO0354

Fracture Risk Is Increased in Young Women with Rheumatoid Arthritis Shreyasee Amin*, Sherine Gabriel, Sara Achenbach, Elizabeth Atkinson, L. Joseph Melton. Mayo Clinic, USA Disclosures: Shreyasee Amin, Merck & Co., 5

Incidence of Subsequent Fractures According to Age and Site of Initial Non-Vertebral Fractures: The First 3 Years of the OPTIMUS Initiative Franc¸ois Cabana1, Miche`le Beaulieu2, Dominique Lambert 3, Pierre-Yves Coˆte´4, Marc Vaillancourt5, Marie-Claude Beaulieu6, Sophie Roux7, Gilles Boire*8. 1Centre hospitalier universitaire de Sherbrooke, Division of Orthopaedics, Canada, 2Merck Canada - Medical Liaison, Canada, 3Warner-Chilcott Canada Co., Canada, 4Amgen Canada, Canada, 5 Novartis Canada, Canada, 6Universite´ de Sherbrooke- Department of Family Medicine, Canada, 7University of Sherbrooke, Canada, 8Centre Hospitalier Universitaire De Sherbrooke, Canada Disclosures: Gilles Boire, Merck Canada; Alliance for Better Bone Health (sanofi-aventis Canada and Warner-Chilcott Canada Co);Amgen Canada; Novartis Canada; Servier Canada, 2

MO0356

Mortality after Vertebral Fracture in Korea : Analysis of the National Claim Registry Young-Kyun Lee*1, Yong-Chan Ha2, Jae-Suk Chang3, Hyun-Koo Yoon4, Deog-Yoon Kim5. 1Seoul National University Bundang Hospital, South Korea, 2Chung-Ang University Hospital, South Korea, 3Ulsan University, Asan Medical Center, South Korea, 4Cheil General Hospital & Women’s Healthcare Center, South Korea, 5Kyung Hee University Hospital, South Korea Disclosures: Young-Kyun Lee, None

263

Monday

MO0355

MO0357

Myocardial Infarction and Stroke Predict Fractures - A 13-Year Follow-Up Study in Men and Women Kerstin Landin-Wilhelmsen*1, Penelope Trimpou2, Anders Lindahl3, Go¨ran Lindstedt3, Go¨ran Olero¨d3, Per-Olof Hansson4, Anders Oden5, Lars Wilhelmsen4. 1Sahlgrenska University Hospital, Sweden, 2Section for Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Sweden, Swe, 3Department of Clinical Chemistry, Sahlgrenska University Hospital, Sweden, 4Department of Medicine, Sahlgrenska University Hospital, Sweden, 5Department of Mathematical Sciences, Chalmers University of Technology, Sweden Disclosures: Kerstin Landin-Wilhelmsen, None

MO0358

Nitrate Use For Angina Is Not Associated with a Reduction in Osteoporotic Fractures in Elderly Women Yasuyo Abe*1, Helena Johansson2, Kiyoshi Aoyagi1, Anders Ode´n 3, Diane Charlesworth 3, Monique Beneton3, Jenny Cliffe3, Linda Kersh3, Carol McGurk3, John Kanis4, Eugene McCloskey 5. 1Nagasaki University, Japan, 2Swedish University of Agricultural Sciences, The Biomedical Center, Sweden, 3WHO Collaborating Centre for Metabolic Bone Diseases, United Kingdom, 4University of Sheffield, Belgium, 5University of Sheffield, United Kingdom Disclosures: Yasuyo Abe, None

MO0359

Prevalence of Back Pain in Postmenopausal Osteoporosis and Associations with Multiple Spinal Factors Naohisa Miyakoshi*1, Michio Hongo1, Hiroyuki Kodama2, Akira Horikawa3, Yoichi Shimada1. 1Akita University Graduate School of Medicine, Japan, 2Minamiakita Orthopedic Clinic, Japan, 3Igarashi Memorial Hospital, Japan Disclosures: Naohisa Miyakoshi, None

MO0360

Prevalence of vertebral fractures in Venezuela. Preliminary report from the Latin American Vertebral Osteoporosis Study (LAVOS). Gregorio Riera-Espinoza* 1, Jenny Ramos2, Ada Colmenares 3, Patricia Clark4, Fidencio Cons Molina5, J.O Talavera6. 1Unidad Metabolica. CEAM, Venezuela, 2Unidad Metabolica, CEAM, Venezuela, 3INE Venezuela, Venezuela, 4Laboratorios Clinicos De Puebla, Mexico, 5Centro De Investigacion En Artritis Y Osteoporosis, Mexico, 6CMN Siglo XXI-IMSS, Mexico Disclosures: Gregorio Riera-Espinoza, None

MO0361

Risk Factors Associated with Secondary Fractures & Mortality in Fracture Patients Managed by a Fracture Liaison Service Alastair McLellan*1, Mayrine Fraser1, Frances Lovell2. 1Western Infirmary, United Kingdom, 2Royal Infirmary, United Kingdom Disclosures: Alastair McLellan, None

MO0362

Secondary Prevention of Osteoporotic Fracture: A Systematic Approach to Case-finding in Brazil Adriana Machado*1, Wellington Monteiro Machado1, Regina Ce´lia Popim 2, Maria Virgı´nia M Alves2, Angela M A Zeller3, Paul James Mitchell4. 1Internal Medicine Department - Univ. Estadual Paulista, Brazil, 2Nurse Department - Univ. Estadual Paulista, Brazil, 3Nutrition Service - Univ. Estadual Paulista, Brazil, 4Auckland, New Zealand & University of Derby, UK, New Zealand Disclosures: Adriana Machado, None

MO0363

Vertebral Fracture Assessment: A Valid Tool to Detect Vertebral Fractures in Elderly Community Diogo Domiciano*1, JAQUELINE LOPES2, Camille Figueiredo1, Vale´ria Caparbo 1, Liliam Takayama1, Rosa Pereira1. 1Faculdade de Medicina da Universidade de Sa˜o Paulo, Brazil, 2Faculdade de Medicina da Universidade de Sa˜o Paulo, Sa˜o Paulo, Brazil, Brazil Disclosures: Diogo Domiciano, None

264

MO0364

Which Types of Fractures Should in General be Regarded as Related to Osteoporosis? Bjorn Rosengren*1, Ingemar Peterson2, Magnus Karlsson1, Martin Englund2. 1Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 2Musculoskeletal Sciences, Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, Sweden Disclosures: Bjorn Rosengren, None

OSTEOPOROSIS EPIDEMIOLOGY: GENETIC STUDIES MO0365

A Genome-wide Screen of Gene-Gene Interactions for Osteoporosis Susceptibility Tie-Lin Yang1, Yan Guo1, Hui Shen2, Qing Tian2, Hong-Wen Deng*2. 1Xi’an Jiaotong University, China, 2Tulane University, USA Disclosures: Hong-Wen Deng, None

MO0366

Allelic Determinants of Vitamin D Insufficiency, Bone Mineral Density and Past and Prospective Bone Fractures Olivia Trummer1, Elisabeth Wehr1, Verena Schwetz1, Daniela Walter1, Markus Gugatschka1, Wilfried Renner1, Astrid Fahrleitner-Pammer2, Harald Dobnig3, Thomas Pieber1, Barbara Obermayer-Pietsch* 2. 1Medical University, Austria, 2Medical University Graz, Austria, 3Diagnostikinstitut Dr.B.Fueger, Institute for Endocrine & Bone Diseases, Aut Disclosures: Barbara Obermayer-Pietsch, None

MO0367

Association of Common Variants in Obesity Related Genes with Osteoporosis and Fracture among Swedish Women Jitender Kumar1, Fiona McGuigan*2, Mattias Callreus1, Paul Gerdhem3, Kristina Akesson4. 1Lund University, Sweden, 2University of Lund, Malmo¨, Skane University Hospital, Malmo¨, Sweden, 3Karolinska Institutet, Sweden, 4Ska˚ne University Hospital, Malmo¨, Sweden Disclosures: Fiona McGuigan, None

MO0368

Linkage Analysis in an Australian Cohort Identifies a Region Associated with Femoral Neck BMD Sing Nguyen*, Jacqueline Center, John Eisman, Tuan Nguyen. Garvan Institute of Medical Research, Australia Disclosures: Sing Nguyen, None

OSTEOPOROSIS EPIDEMIOLOGY: LIFESTYLE AND BONE (ALCOHOL, TOBACCO) MO0369

Disclosures: Stephen Gehlbach, None

OSTEOPOROSIS EPIDEMIOLOGY: MENOPAUSE AND GONADAL STEROIDS MO0370

Secular Trends in Fractures and Sex Hormones in Men and Women Penelope Trimpou*1, Anders Lindahl2, Go¨ran Lindstedt2, Go¨ran Olero¨d 2, Lars Wilhelmsen2, Kerstin Landin-Wilhelmsen2. 1Section for Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Sweden, Swe, 2Sahlgrenska University Hospital, Sweden Disclosures: Penelope Trimpou, None

265

Monday

Factors Associated with Use of Anti-Osteoporosis Medication. The Global Longitudinal Study of Osteoporosis in Women (GLOW) Stephen Gehlbach*1, Pamela Guggina2, Frederick Hooven3, Julie Flahive4, Steven Boonen5, Juliet Compston6, Cyrus Cooper7, Adolfo Diez-Perez8, Susan Greenspan9, Robert Lindsay10, Coen Netelenbos11, Philip Sambrook12, Stuart Silverman13, Nelson Watts14. 1University of Massachusetts, USA, 2University of Massachusetts School of Public Health, USA, 3University of Massachusetts Medical School, USA, 4UMass Medical School, USA, 5Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 6University of Cambridge School of Clinical Medicine, United Kingdom, 7 University of Southampton, United Kingdom, 8Autonomous University of Barcelona, Spain, 9University of Pittsburgh, USA, 10Helen Hayes Hospital, USA, 11VU Medical Center, The Netherlands, 12Royal North Shore Hospital, Australia, 13Cedars-Sinai/UCLA, USA, 14University of Cincinnati Bone Health & Osteoporosis Center, USA

MO0371

The Relationship Between Circulating Soluble RANK Ligand and Breast Arterial Calcification in Japanese Postmenopausal Women. Fuminori Hirano*1, Hiroshi Wada2, Hideo Nishimura 1. 1Asahikawa Medical Center, Japan, 2Wada women’s clinic, Japan Disclosures: Fuminori Hirano, None

OSTEOPOROSIS EPIDEMIOLOGY: RISK FACTORS MO0372

Aging Males’ Symptoms (AMS) Scale and Bone Mineral Density in HIV Positive Males Treated with Highly Active Anti-Retroviral Therapy (HAART) Jessica Pepe1, Andrea Isidori1, Mario Falciano1, Giancarlo Iaiani1, Emilia Sbardella1, Romano Del Fiacco2, Addolorata Scarpiello1, STEFANIA RUSSO3, Cristiana Cipriani4, Elisabetta Romagnoli4, Salvatore Minisola* 4. 1Sapienza, University of Rome, Italy, 2 University "Sapienza" - Rome, Italy, 3UNIVERSITY SAPIENZA OF ROME (ITALY), Italy, 4University of Rome, Italy Disclosures: Salvatore Minisola, None

MO0373

Association of Red Blood Cell n-3 and n-6 Fatty Acids and Hip Fracture Tonya Orchard*1, Steven Ing1, Bo Lu 1, Martha Belury1, Andrea Lacroix2, Charles Kooperberg 2, Aaron Aragaki 2, Rebecca Jackson1. 1The Ohio State University, USA, 2Fred Hutchinson Cancer Research Center, USA Disclosures: Tonya Orchard, None

MO0374

Body Mass Index and Bone Mineral Density in Adults over 50: Results from NHANES 20052008 Jennifer Lloyd*1, Dawn Alley1, William Hawkes1, Shari Waldstein2, Marc Hochberg3, Denise Orwig1. 1University of Maryland, Baltimore, USA, 2University of Maryland, Baltimore County, USA, 3University of Maryland School of Medicine, USA Disclosures: Jennifer Lloyd, None

MO0375

Does Optimal Risk Factor Profile Guarantee Better Bone Health During The Postmenopause? - A 15-Year Population Based Study Joonas Sirola*1, Toni Rikkonen2, Marjo Tuppurainen3, Risto Honkanen4, Heikki Kro¨ger3. 1 University of Eastern Finland / Kuopio, Finland, 2Reseacher, University of Eastern Finland, Finland, 3Professor, Kuopio university hospital, Finland, 4Adjunct Professor, University of Eastern Finland, Finland Disclosures: Joonas Sirola, None

MO0376

Does Work Disability Predict Fractures? Pa¨ivi Rauma*1, Risto Honkanen2, Marjo Tuppurainen3, Heli Koivumaa-Honkanen4, Heikki Kro¨ger5. 1University of Eastern Finland, Finland, 2BCRU & Public Health, University of Eastern Finland, Finland, 3Kuopio University Central Hospital, Finland, 4 University of Oulu, Finland, 5BCRU, University of Eastern Finland, Finland Disclosures: Pa¨ivi Rauma, None

MO0377

Effect of Co-Morbidities on Fracture Risk: Findings from The Global Longitudinal Study of Osteoporosis in Women Juliet Compston*1, Melissa Premaor 2, Julie Flahive3, Ethel Siris 4, Stephen Gehlbach5, Jonathan Adachi6, Steven Boonen7, Roland Chapurlat8, Adolfo Diez-Perez9, Frederick Hooven10, Andrea Lacroix11, Coen Netelenbos12, Johannes Pfeilschifter 13, Maurizio Rossini 14, Christian Roux15, Kenneth Saag16, Philip Sambrook17, Stuart Silverman18, Nelson Watts19, Susan Greenspan20, Elaine Dennison21, Cyrus Cooper22. 1University of Cambridge School of Clinical Medicine, United Kingdom, 2Federal University of Santa Maria, Brazil, 3UMass Medical School, USA, 4Columbia University College of Physicians & Surgeons, USA, 5University of Massachusetts, USA, 6St. Joseph’s Hospital, Canada, 7 Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 8E. Herriot Hospital, France, 9Autonomous University of Barcelona, Spain, 10University of Massachusetts Medical School, USA, 11Fred Hutchinson Cancer Research Center, USA, 12 VU Medical Center, The Netherlands, 13Alfried Krupp Krankenhaus Steele, Germany, 14 University of Verona, Italy, 15Hospital Cochin, France, 16University of Alabama at Birmingham, USA, 17Royal North Shore Hospital, Australia, 18Cedars-Sinai/UCLA, USA, 19 University of Cincinnati Bone Health & Osteoporosis Center, USA, 20University of Pittsburgh, USA, 21MRC Epidemiology Resource Centre, United Kingdom, 22University of Southampton, United Kingdom Disclosures: Juliet Compston, None

266

MO0378

Fragility Fracture and Osteoarthritis: Interaction between Bone Mineral and Bone Mass Index Mei Chan*1, Tuan Nguyen2, Jacqueline Center2, John Eisman2, Nguyen Nguyen2. 1 Osteoporosis & Bone Biology, Australia, 2Garvan Institute of Medical Research, Australia Disclosures: Mei Chan, None

MO0379

Insulin Resistance Independently Had the Negative Association with the Bone Mineral Density in Normal Fasting Glucose Tolerance and Impaired Fasting Glucose Not in Diabetes Sangmo Hong*1, Chang Beom Lee 1, Yong Soo Park1, Dong Sun Kim1, You Hern Ahn1, Tae Wha Kim1, Woong Choi2. 1Endocrinology & metabolism, Hanyang University College of medicine, South Korea, 2Hanyang University Hospital, South Korea Disclosures: Sangmo Hong, None

MO0380

Later Menarche is Associated with Increased Risk of Fracture During Growth and with Reduced Bone Strength as Assessed by FEA in Healthy 20-Year Old and in Premenopausal Women Thierry Chevalley*1, Jean-Philippe Bonjour 2, Bert van Rietbergen3, Serge Ferrari4, Rene Rizzoli5. 1University Hospitals of Geneva Division of Bone Diseases, Switzerland, 2 University Hospital of Geneva, Switzerland, 3Department of Biomedical Engineering, Eindhoven University of Technology, Netherlands, 4Geneva University Hospital & Faculty of Medicine, Switzerland, 5University Hospital, Switzerland Disclosures: Thierry Chevalley, None

MO0381

Preliminary Analysis of Vertebral Fracture Risk Among Type 2 Diabetic Latinos in San Antonio, TX Roberto Fajardo*1, Krista Kilpadi2, Robert Eldabaje2, James Schmitz2, Julie Sottilo2, Todd Thames3, Ajeya Joshi4, James Simmons5. 1UT Health Science Center, San Antonio, USA, 2University of Texas Health Science Center at San Antonio, USA, 3Christus Santa Rosa Hospital, USA, 4South Texas Spinal Length, USA, 5South Texas Spinal Clinic, USA Disclosures: Roberto Fajardo, None

MO0382

Serum Cystatin C and Risk of Hip and Nonvertebral Fractures in Older Men Kristine Ensrud*1, Neeta Parimi2, Howard Fink3, Areef Ishani4, Michael Steffes5, Jane Cauley6, Eric Orwoll7. 1Minneapolis VA Medical Center / University of Minnesota, USA, 2 California Pacific Medical Center Research Institute, USA, 3GRECC, Minneapolis VA Medical Center, USA, 4Univeristy of Minnesota / VA Medical Center, USA, 5Univeristy of Minnesota, USA, 6University of Pittsburgh Graduate School of Public Health, USA, 7 Oregon Health & Science University, USA Disclosures: Kristine Ensrud, None

MO0383

The Presence of Arteriosclerosis is a Risk Factor for Vertebral Fracture in Patients with Type 2 Diabetes Masahiro Yamamoto*1, Toru Yamaguchi 1, Mika Yamauchi1, Shozo Yano1, Toshitsugu Sugimoto2. 1Shimane University Faculty of Medicine, Japan, 2Shimane University School of Medicine, Japan

MO0384

Thyroid Function, Bone Loss, and Fracture in Older Men: The MrOS Study Douglas Bauer*1, Stephanie Harrison2, Howard Fink3, Mary H. Samuels4, Peggy Cawthon5, Avantika Waring1, Joseph Zmuda6, Eric Orwoll4. 1University of California, San Francisco, USA, 2San Francisco Coordinating Center, USA, 3GRECC, Minneapolis VA Medical Center, USA, 4Oregon Health & Science University, USA, 5California Pacific Medical Center Research Institute, USA, 6University of Pittsburgh Graduate School of Public Health, USA Disclosures: Douglas Bauer, None

MO0385

Vitamin D Insufficiency and Occurrence of Osteoporosis and Disability: The ROAD Study Noriko Yoshimura*1, Shigeyuki Muraki1, Hiroyuki Oka1, Hiroshi Kawaguchi2, Kozo Nakamura3, Toru Akune1. 122nd Century Medical & Research Center, University of Tokyo, Japan, 2University of Tokyo, Faculty of Medicine, Japan, 3The University of Tokyo, Japan Disclosures: Noriko Yoshimura, None

MO0386

What Are the Risk Factors for Bone Loss in Lupus Patients? Ioana Moldovan*, Emmanuel Katsaros. Loma Linda University, USA Disclosures: Ioana Moldovan, None

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Disclosures: Masahiro Yamamoto, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE MINERAL DENSITY MO0387

Comparison of Comparison of Histomorphometric Parameters of Bone Structure in the Femoral Neck in Osteoporosis and Osteoarthritis Yasemin Cinar1, Funda Atamaz Calis2, Yesim Kirazli*1, Basak Doganavsargil 3, Murat Sezak3, Nadir Ozkayin4, Semih Aydogdu4, Kemal Aktuglu4. 1Ege University Medical Faculty, Physical Therapy & Rehabilitation, Turkey, 2Ege University Medical Faculty, Turkey, 3Ege University Medical Faculty, Pathology, Turkey, 4Ege University Medical Faculty, Orthopaedic Surgery, Turkey Disclosures: Yesim Kirazli, None

MO0388

Determinants of Circulating Vitamin D and Bone Density in a Young Adult Physician Population. Terri Washington, Buvana Manickam*, Aaron Benjamin, Elena Barengolts, Elizabeth Villagrana, Subhash Kukreja. University of Illinois, USA Disclosures: Buvana Manickam, None

MO0389

Effect of Voluntary Exercise and Energy Restriction on Bone Mineral Density in Female Rat Model Kaoru Yanaka*1, Mitsuru Higuchi2, Yoshiko Ishimi1. 1Waseda University & National Institute of Health & Nutrition, Japan, 2Waseda University, Japan Disclosures: Kaoru Yanaka, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE REMODELING MO0390

Bone Turnover Markers in Subclinical Hyperthyroidism Ana Paula Barbosa*1, Mario Rui Mascarenhas 2, Anto´nio Gouveia de Oliveira3, Vera Simo˜es4, Ana Gonc¸alves5, David Santos Pinto6, Manuel Bicho7, Isabel do Carmo5. 1 Endocrinology University Clinic & Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), CEDML - Endocrinology, Diabetes & Metabolism Clinic, Lda., Endocrinology, Diabetes & Metabolism Department, Santa Maria Hospital, CHLN-EPE, Portugal, 2Faculdade de Medicina Lisboa, Portugal, 3Biostatistics Department, FCMUNL, Portugal, 4Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), CEDML Endocrinology, Diabetes & Metabolism Clinic, Lda., Portugal, 5Endocrinology, Diabetes & Metabolism Department, Santa Maria Hospital, CHLN-EPE, Portugal, 6CEDML Endocrinology, Diabetes & Metabolism Clinic, Lda., Portugal, 7Metabolism & Endocrinology Center, Genetics Laboratory (FMUL), Portugal Disclosures: Ana Paula Barbosa, None

MO0391

Idiopathic Osteoporosis in Premenopausal Women: Bone Turnover Provides Clues to Pathogenesis Adi Cohen*1, Emily Stein2, David Dempster3, Hua Zhou4, Serge Cremers3, Clifford Rosen5, Thomas Nickolas1, Thomas Kohler6, Andreas Wirth7, Harry Van Lenthe8, Ralph Muller6, Polly Chen1, Robert Recker9, Joan Lappe10, Elizabeth Shane2. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA, 4Helen Hayes Hospital, USA, 5Maine Medical Center, USA, 6ETH Zurich, Switzerland, 7Institute for Biomechanics, ETH Zurich, Switzerland, 8 Katholieke Universiteit Leuven, Belgium, 9Creighton University Osteoporosis Research Center, USA, 10Creighton University, USA Disclosures: Adi Cohen, None

MO0392

Preliminary Clinical Study Regarding Improvement of Dental Implants Stability In Osteoporosis Horia Barbu*1, Andreea Brehar1, Monica Comaneanu 1, Adi Lorean2, Doina Ghergic1, Constantin Dumitrache1. 1Romania, 2Israel Disclosures: Horia Barbu, None

268

MO0393

Reduction in Circulating Estrogen and Increase in Postprandial Serotonin Levels in Subjects with Helicobacter Pylori CagA+ Infection: Effects on Circadian Rhythm of Bone Turnover and Skeletal Health Luigi Gennari*1, Daniela Merlotti1, Natale Figura2, Maria Stella Campagna2, Maria Beatrice Franci2, Anna Calabro`2, Annalisa Avanzati2, Barbara Lucani2, Stefania Lardiello2, Leonardo Vaglio2, Konstantinos Stolakis2, Ranuccio Nuti1. 1University of Siena, Italy, 2Department of Internal Medicine, Endocrine-Metabolic Sciences & Biochemistry, University of Siena, Italy Disclosures: Luigi Gennari, None

OSTEOPOROSIS PATHOPHYSIOLOGY: BONE STRUCTURE MO0394

Aging of Iliac Cortical Bone in Normal Women and Men ANNE-SOPHIE BRAVO MARTIN* 1, Jean-Charles Giunta1, Roland Chapurlat2, Georges Boivin3. 1INSERM, UMR 1033 ; Universite´ de Lyon, France, 2E. Herriot Hospital, France, 3INSERM, UMR 1033 ; Universite de Lyon, France Disclosures: ANNE-SOPHIE BRAVO MARTIN, None

MO0395

The Interaction Between Calcium and Vitamin D Intake on PTH and Bone Biomarkers. Mageda Mikhail*. Winthrop University Hospital, USA Disclosures: Mageda Mikhail, None

OSTEOPOROSIS PATHOPHYSIOLOGY: DIETARY FACTORS MO0396

Bone Mineral Density (BMD) Loss Due to Weight Reduction Differs in Obese and Overweight: The Contribution of Fat and Lean Tissue Sue Shapses* 1, Claudia Pop1, Deeptha Sukumar1, Robert Zurfluh1, Steven Heymsfield2, Yvette Schlussel1. 1Rutgers University, USA, 2Pennington biomedical Research Center, USA Disclosures: Sue Shapses, None

MO0397

Determination of Serum Sclerostin Levels in Women with Anorexia Nervosa Christina Bittighofer*1, Julia Wild2, Angela Trubrich1, Judith Haschka3, Roland Kocijan4, Wolfgang Woloszczuk 5, Stylianos Kapiotis6, Sebastian Dinu6, Christian Muschitz3, Heinrich Resch7. 1The VINFORCE Study Group - St. Vincent Hospital – Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Austria, 2 Medical University of Vienna, Department of Obstetrics & Gynecology, Austria, 3St. Vincent’s Hospital, Austria, 4St.Vincent Hospital Vienna, Austria, 5Biomarker Design ForschungsGmbH, Vienna, Austria, Austria, 6Central Laboratory St. Vincent Group, Austria, 7Medical University Vienna, Austria Disclosures: Christina Bittighofer, None

MO0398

Disclosures: Karen Hansen, None

OSTEOPOROSIS PATHOPHYSIOLOGY: GONADAL STEROIDS MO0399

Physiological Supplementation of Sex Steroids Suppresses Bone Turnover in Male But Not Female Gonadectomized Mice Alexandra Heyny*, Carmen Streicher, Reinhold Erben. University of Veterinary Medicine, Austria Disclosures: Alexandra Heyny, None

MO0400

Sclerostin Production Decreases after Ovariectomy in Mouse Bones in Association with an Increase in Bone Formation. Sandra Jastrzebski1, Judith Kalinowski1, Yurong Fei1, Shilpa Choudhary1, Carol Pilbeam1, Faryal Mirza1, Marja Marie Hurley2, Joseph Lorenzo*1. 1University of Connecticut Health Center, USA, 2University of Connecticut Health Center School of Medicine, USA Disclosures: Joseph Lorenzo, None

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Factors Associated with Fractional Calcium Absorption (FCA) in Postmenopausal Women Karen Hansen*1, Andrea Jones2, Lisa Davis1, Elizabeth Crone 1, Christina Lemon1, Diane Burroughs 1, Martin Shafer3. 1University of Wisconsin, USA, 2University of Wisconsin School of Medicine & Public Health, USA, 3Wisconsin State Lab of Hygiene, USA

OSTEOPOROSIS PATHOPHYSIOLOGY: MALE OSTEOPOROSIS MO0401

Myostatin Serum Concentrations in Men – Age-Related Changes and Correlates – the STRAMBO Study Pawel Szulc*1, Claudia Goetsch2, Michael Schoppet3, Roland Chapurlat4, Lorenz Hofbauer 5. 1Hopital E. Herriot, Pavillon F, France, 2University of Dresden, Germany, 3 University of Marburg, Germany, 4E. Herriot Hospital, France, 5Dresden Technical University Medical Center, Germany Disclosures: Pawel Szulc, None

MO0402

Relationship Between Serum Testosterone and Fracture Risk in Men: A Comparison of Radioimmunoassay Versus Liquid Chromatography Tandem Mass Spectrometry Thach Son Tran*1, Nguyen Nguyen1, Jacqueline Center1, Markus Seibel2, John Eisman1, Tuan Nguyen1. 1Garvan Institute of Medical Research, Australia, 2Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia Disclosures: Thach Son Tran, None

OSTEOPOROSIS PATHOPHYSIOLOGY: MISCELLANEOUS MO0403

Contribution of Enzymatic and Non-Enzymatic Collagen Crosslinks to Femoral Neck Fragility. Comparison Between Osteoporosis and Osteoarthritis Evelyne Gineyts*1, Nathalie R Portero-Muzy 1, Hubert Blain 2, Roland D Chapurlat1, Pascale M Chavassieux 1. 1INSERM, UMR 1033, Universite´ de Lyon, France, 2Department of Geriatrics, CHU of Montpellier, France Disclosures: Evelyne Gineyts, None

MO0404

Increased Expression of the Purinergic P2Y2 Receptor Results in Increased Resorption and Decreased Bone in vivo Ning Wang1, Peter Schwarz2, Susanne Syberg*2, Solveig Petersen3, Cansu Agca4, Niklas Jorgensen5, Yuksel Agca6, Alison Gartland7. 1The University of Sheffield, United Kingdom, 2 Glostrup Hospital, Denmark, 3Laboratory Technician, Denmark, 4Research Scientist, postdoc, USA, 5Copenhagen University Hospital Glostrup, Denmark, 6Prof, Asoc, USA, 7 The Mellanby Centre for Bone Research, The University of Sheffield, United Kingdom Disclosures: Susanne Syberg, None

MO0405

Normal Histomorphometric Reference Ranges for Cortical Bone Width and Cortical Porosity in Adult Females. Donna Jewison*1, Robert Wermers2, Stephen Hodgson2, Thomas J. Sebo3, Michael Yaszemski 4, Theresa Hefferan2. 1Mayo Clinic Rochester, MN, USA, 2Mayo Clinic, USA, 3 Mayo Clinic Rochester, USA, 4Mayo Clinic College of Medicine, USA Disclosures: Donna Jewison, None

MO0406

Osteoblastic Differentiation is Inhibited by Warfarin and 18-a-glycyrrhetinic Acid Dong Jin Chung*1, Yun-Hey Jin2, Dong Hyeok Cho1, Hyung Min Jeong2, Jin Ook Chung1, Min Young Chung1, Kwang Youl Lee 2. 1Chonnam National University Medical School, South Korea, 2College of Pharmacy & Research Institute of Drug Development, Chonnam National University, South Korea Disclosures: Dong Jin Chung, None

MO0407

Total and Carboxylated Osteocalcin Associate with Serum Insulin and Bone Mineral Density in Young Adults Paivi Maria Paldanius*1, Kaisa Ivaska2, Petteri Hovi1, Sture Andersson1, Johan Eriksson3, Kalervo Vaananen4, Eero Kajantie1, Outi Makitie1. 1Children’s Hospital, Helsinki University Hospital, Finland, 2University of Turku, Department of Cell Biology & Anatomy, Finland, 3Department of General Practice & Primary Health Care, University of Helsinki, Finland, 4University of Eastern Finland, Finland Disclosures: Paivi Maria Paldanius, Novartis, 1; Novartis, 3

270

MO0408

Vertebral Marrow Fat and Body Composition in Older Men and Women: Preliminary results from the AGES-BMA study Trisha Hue*1, Xiaojuan Li1, Clifford Rosen2, Vilmundur Gudnason3, Thomas Lang1, Sigurdur Sigurdsson3, KRISTIN SIGGEIRSDOTTIR3, Gunnar Sigurdsson4, Keerthi Shet1, Tamara Harris5, Lisa Palermo1, Ann Schwartz1. 1University of California, San Francisco, USA, 2Maine Medical Center, USA, 3Icelandic Heart Association Research Institute, Iceland, 4Landspitali, Iceland, 5Intramural Research Program, National Institute on Aging, USA Disclosures: Trisha Hue, None

OSTEOPOROSIS TREATMENT (CLINICAL): ANABOLIC AGENTS MO0409

Clinical Development of An Orally Delivered Recombinant PTH Analog Nozer Mehta*1, Roxanne Tavakkol2, Kristine Erickson2, Bill Stern2, Tamara James2, Seymour Fein 2, Sheela Mitta2, Amy Sturmer2, Paul Shields2, Andy Rasums2, Lorraine Fitzpatrick3. 1Unigene Laboratories, Incorporated, USA, 2Unigene Laboratories, USA, 3 GlaxoSmithKline, USA Disclosures: Nozer Mehta, Unigene Laboratories, 3

MO0410

Cumulative Doses of PTH (1-84) Stimulates Vasodilation in the Bone Vasculature of Rats: the Role of VEGF and NO Signaling Pathways Rhonda Prisby*, Jeremiah Campbell, Thomas Menezes. University of Texas at Arlington, USA Disclosures: Rhonda Prisby, None

MO0411

Effects of One Year Daily Teriparatide Treatment on Trabecular Bone Material Properties in Postmenopausal Osteoporotic Women Previously Treated with Alendronate or Risedronate Sonja Gamsjaeger 1, Birgit Buchinger1, Roger Phipps2, Klaus Klaushofer 1, Eleftherios Paschalis* 1. 1Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK & AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Austria, 2 Husson University School of Pharmacy, USA Disclosures: Eleftherios Paschalis, None

MO0412

Postmenopausal Women Treated with Combination Parathyroid Hormone and Ibandronate Experience Different Cortical Bone Microstructural Changes at the Radius and Tibia: The PICS Study Anne Schafer*1, Andrew Burghardt2, Lisa Palermo2, Deborah Sellmeyer3, Sharmila Majumdar2, Dennis Black2. 1University of California, San Francisco & the San Francisco VA Medical Center, USA, 2University of California, San Francisco, USA, 3The Johns Hopkins Bayview Medical Center, USA Disclosures: Anne Schafer, None

MO0413

Disclosures: Jeri Nieves, None MO0414

Two-Year Effects of PTH(1-84) On Cortical Bone In Hypoparathyroidism Stephanie Boutroy*1, Mishaela Rubin2, Jim Sliney Jr 3, Rebecca Ives3, John Bilezikian4. 1 Columbia University Medical Center, New York, NY, USA, USA, 2Columbia University, USA, 3Columbia University Medical Center, USA, 4Columbia University College of Physicians & Surgeons, USA Disclosures: Stephanie Boutroy, None

271

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Teriparatide Treatment for 24 Months in Postmenopausal Women with Osteoporosis Differentially Impacts Cortical and Trabecular Bone at the Tibia Assessed by HRpQCT Jeri Nieves*1, Felicia Cosman1, Stephanie Boutroy2, Nancy Barbuto1, Marsha Zion1, Elizabeth Shane3, David Dempster2, Robert Lindsay1. 1Helen Hayes Hospital, USA, 2 Columbia University, USA, 3Columbia University College of Physicians & Surgeons, USA

OSTEOPOROSIS TREATMENT (CLINICAL): BISPHOSPHONATES MO0415

Antiresorptive Treatment for Spaceflight Induced Bone Atrophy: Preliminary Results Adrian Leblanc*1, Toshio Matsumoto 2, Jeff Jones3, Jay Shapiro4, Thomas Lang5, Linda Shackelford6, Scott Smith 6, Harlan Evans7, Elisabeth spector7, Robert ploutz-Snyder 8, Jean Sibonga6, Toshitaka Nakamura 9, Kenjiro Kohri10, Hiroshi Ohshima11. 1USRA, Baylor College of Medicine, USA, 2University of Tokushima Graduate School of Medical Sciences, Japan, 3Baylor College of Medicine, USA, 4Johns hopkins, USA, 5University of California, San Francisco, USA, 6NASA, USA, 7Wyle, USA, 8USRA, USA, 9University of Occupational & Environmental Health, Japan, 10Nagoya City University, Japan, 11JAXA, Japan Disclosures: Adrian Leblanc, None

MO0416

Atypical Femoral Fractures in Association with Long-term Bisphosphonate Use: Clinical, Radiographic and Bone Biopsy Data from 7 Cases Aliya Khan*1, Angela Cheung2, Sama Thomas1, Nazir Khan1, Kenneth Pritzker2, Brian Lentle3. 1McMaster University, Canada, 2University of Toronto, Canada, 3University of British Columbia, Canada Disclosures: Aliya Khan, None

MO0417

Augmentation of Bisphosphonate Effects Increasing Lumbar Bone Mineral Density and Decreasing Vertebral Deformity by Addition of Active Absorbable Algal Calcium (AAACa) Yoshitomo Itakura1, Yoshio Fujii2, Yasuyuki Takagi3, Takuo Fujita*4, Mutsumi Ohue4, Akimitsu Miyauchi5, Mikio Nakajima6. 1Komatsu Hospital, Japan, 2Calcium Research Institute Kobe Branch, Japan, 3National Hyogo Chuo Hospital, Japan, 4Katsuragi Hospital, Japan, 5Miyauchi Medical Center, Japan, 6Dept of Orthopedic Surgery, Osaka Medical College, Japan Disclosures: Takuo Fujita, None

MO0418

Biochemical markers and its relation with Bisphosphonate-related Osteonecrosis of the Jaw in Female Osteoporosis patients Tae-Geon Kwon*1, Je-Yong Choi2, So-Young Choi3. 1Kyungpook National University, School of Dentistry, South Korea, 2Kyungpook National University, School of Medicine, South Korea, 3Kyungpook National University, Republic of Korea Disclosures: Tae-Geon Kwon, None

MO0419

Generic Alendronate Use in Medicare Part D Data Huifeng Yun*1, Jeffrey Curtis1, Wilson Smith1, Robert Matthews 1, Kenneth Saag1, Nicole Wright1, Meredith Kilgore2, Elizabeth Delzell1. 1University of Alabama at Birmingham, USA, 2University of Alabama At Birmingham School of Public Health, USA Disclosures: Huifeng Yun, AMGEN, 2

MO0420

Prevention of Postmenopausal Osteoporosis With Two Intermittent Alendronate Regimens: Bone Mineral Density and Bone Markers Changes After 12 Months Yves Boutsen*1, Jacques Jamart2, Catherine Vynckier2, Thierry Vander Borght2, JeanPierre Devogelaer 3. 1Cliniques Universitaires UCL de Mont-Godinne, Belgium, 2Cliniques Universitaires de Mont-Godinne, Belgium, 3St. Luc University Hospital, Belgium Disclosures: Yves Boutsen, None

MO0421

Real-Life Effectiveness of Zoledronic Acid in Patients with Osteoporosis Emmanouil Rampakakis 1, Georges Tsoukas2, John S. Sampalis*3. 1JSS Medical Research, Canada, 2McGill University, Can, 3McGill University & Jewish General Hospital, Canada Disclosures: John S. Sampalis, None

MO0422

Regional Bone Metabolism at the Lumbar Spine and Hip Following Discontinuation of Alendronate and Risedronate Treatment in Postmenopausal Women Michelle Frost* 1, Musib Siddique1, Glen M. Blake1, Amelia EB. Moore1, Paul K. Marsden1, Paul J. Schleyer1, Richard Eastell2, Ignac Fogelman3. 1King’s College London, United Kingdom, 2University of Sheffield, United Kingdom, 3Guy’s Hospital, United Kingdom Disclosures: Michelle Frost, Warner Chilcott, 2

272

MO0423

Relationship Between Baseline Serum 25-Hydroxyvitamin D and Response to Risedronate in Postmenopausal Osteoporosis Patients - A Pooled Analysis of Clinical Trials in Japan Ryo Okazaki*1, Ryoichi Muraoka2. 1Teikyo University Chiba Medical Center, Japan, 2 Ajinomoto Phamaceuticals Co, Ltd., Japan Disclosures: Ryo Okazaki, None

MO0424

Relationship of Changes in Total Hip Bone Mineral Density to Vertebral and Non-Vertebral Fracture Risk in Women with Postmenopausal Osteoporosis Treated with Once-Yearly Zoledronic Acid 5 mg (ZOL): the HORIZON-PFT study Richard Jacques1, Steven Boonen2, Felicia Cosman3, Ian Reid4, Douglas Bauer5, Dennis Black5, Richard Eastell* 1. 1University of Sheffield, United Kingdom, 2Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 3Helen Hayes Hospital, USA, 4 University of Auckland, New Zealand, 5University of California, San Francisco, USA Disclosures: Richard Eastell, None

MO0425

The Intra-Venous Zoledronic acid once Yearly (IVORY) observational study: Baseline and one year data David Kendler*. Osteoporosis Research Centre, Canada Disclosures: David Kendler, J&J, 2; Pfizer, 2; Merck, 2; Servier, 2; Amgen, 2; GSK, 2; Eli Lilly, 2; Novartis, 2; Boehringer, 2

MO0426

The Use of Screening Radiographs to Detect Incomplete Atypical Femoral Fractures in Asymptomatic Patients on Bisphosphonate Therapy Renata La Rocca Vieira1, Zehava Sadka Rosenberg1, Mary Allison*2, Shelly Im1, Valerie Peck3. 1NYU Medical Center, USA, 2NYU Langone Medical Center, USA, 3NYU School of Medicine, USA Disclosures: Mary Allison, None

MO0427

Thirteen Cases of Atypical Subtrochanteric and Diaphyseal Femoral Fractures among the 2,238 cases of Femoral Fractures Occurred during 2006 to 2010 in Japan Yoshitomo Saita*1, Muneaki Ishijima 1, Atsuhiko Mogami2, Tomonori Baba3, Masashi Nagao4, Kensuke Sakai4, Yasuhiro Homma2, Rui Kato5, Kei Miyagawa6, Nana Nagura2, Tomoki Wada2, Osamu Obayashi2, Hogaku Gen6, Hajime Kajihara5, Masahiko Nozawa4, Katsuo Shitoto7, Kazuo Kaneko1. 1Department of Orthopaedics, Juntendo University School of Medicine, Japan, 2Department of Orthopaedic Surgery, Juntendo Shizuoka Hospital, Japan, 3Department of Orthopaedic Surgery, Juntendo Urayasu Hospital, Japan, 4 Department of Orthopaedic Surgery, Juntendo Nerima Hospital, Japan, 5Department of Orthopaedic Surgery, Koto Hospital, Japan, 6Department of Orthopaedic Surgery, Chiba Central Medical Center, Japan, 7 Department of Orthopaedic Surgery, Juntendo Urayasu Hospital, Japan Disclosures: Yoshitomo Saita, None

MO0428

Disclosures: Astrid Fahrleitner-Pammer, Financial, 5

OSTEOPOROSIS TREATMENT (CLINICAL): COMPLIANCE AND PERSISTENCE MO0429

Associations Between Osteoporosis (OP) Treatment Change, Adherence, and Incident Fractures Among Members in a Medicare Advantage Prescription Drug (MAPD) Plan Yihua Xu1, Melea Ward1, Hema Viswanathan2, John Adams3, Bradley Stolshek* 2, Reginald Clay 2, John Kallich2, Kenneth Saag4. 1Competitive Health Analytics, Inc, USA, 2 Amgen Inc., USA, 3RAND Corporation, USA, 4University of Alabama at Birmingham, USA Disclosures: Bradley Stolshek, Competitive Health Analytics, 3

273

Monday

Three-monthly i.v. Ibandronate Following Long-term Treatment With Oral Alendronate; Results From a Two-year Prospective Open-labeled Study Astrid Fahrleitner-Pammer*1, Karlheinz Fenzl2, Doris Wagner3, Christian Muschitz4, Karin Amrein3, Thomas Pieber5, Barbara Obermayer-Pietsch1, Hans Dimai1. 1Medical University Graz, Austria, 2Roche Austria, Austria, 3Medical University of Graz, Austria, 4 St. Vincent’s Hospital, Austria, 5Medical University of Graz, Dept of Internal Medicine, Div. of Endocrinology & Metabolism, Austria

MO0430

Does Medication Adherence Itself Confer Fracture Protection? An Investigation of the Healthy Adherer Effect in Observational Data Jeffrey Curtis*1, Jeff Lange2, Huifeng Yun1, Elizabeth Delzell 1. 1University of Alabama at Birmingham, USA, 2Procter & Gamble, USA Disclosures: Jeffrey Curtis, Merck, 2; Eli Lilly,5; Merck, 5; Novartis, 2; Novartis, 5; Proctor and Gamble, 2; Eli Lilly, 2; Amgen, 2; Roche, 2; Amgen, 5; Roche, 5

MO0431

First Interim Results of the German Non-Interventional Study (NIS) VIVA to Assess the Compliance, Safety, and Effectiveness of Quarterly i.v. Ibandronate (IBN) vs. Weekly Oral Alendronate (ALN) in Patients with Postmenopausal Osteoporosis Peyman Hadji*. Philipps-University of Marburg, Germany Disclosures: Peyman Hadji, None

MO0432

Optimizing Communication of DXA Results and Fracture Risk to Patients: A Mixed Methods Study Stephanie Edmonds*1, Samantha Solimeo1, Douglas Roblin2, Kenneth Saag3, Peter Cram1. 1University of Iowa, USA, 2Kaiser Permanente, USA, 3University of Alabama at Birmingham, USA Disclosures: Stephanie Edmonds, None

MO0433

Osteoporosis Treatment Initiation and Withdrawal: Evidence of Therapeutic Hysteresis in Clinical Practice William Leslie*1, Suzanne Morin2, Lisa Lix3. 1University of Manitoba, Canada, 2McGill University Health Centre, Canada, 3University of Saskatchewan, Canada Disclosures: William Leslie, None

MO0434

Persistence of Therapy With Zoledronic Acid Infusion For Osteoporosis Christine Simonelli*1, Julie Morancey 1, Jean Lian2, Yoona Kim2. 1HealthEast Osteoporosis Services, USA, 2Novartis, USA Disclosures: Christine Simonelli, Eli Lilly, 5; Amgen, 2; Novartis, 8; Noartis, 2; Amgen, 8; Eli Lilly, 8

MO0435

Persistence, Gaps in Therapy, and Re-initiation of Osteoporosis (OP) Therapy Among Women in a Commercially Insured US Population Akhila Balasubramanian* 1, Alan Brookhart2, Vamshidar Goli3, Cathy Critchlow4. 1 Amgen Inc, USA, 2University of North Carolina at Chapel Hill, USA, 3Amgen Inc., USA, 4 Amgen, USA Disclosures: Akhila Balasubramanian, Amgen Inc, 1; Amgen Inc, 3

MO0436

The Persistence in the Health District of Cosenza (Calabria, Italy) Claudia Carbone*1, Alfonso Reda2, Maria Gabriella Bartoletti 3, Brunella Piro 1, Luisa Gallo1. 1Servizio Farmaceutico ASP Cosenza, Italy, 2Italy, 3Centro di Riabilitazione Biolife, Italy Disclosures: Claudia Carbone, None

MO0437

Treatment of Osteoporosis with zoledronic acid: what is the Persistence at one year in Clinical Practice? Estelle Rose1, Thierry Lequerre2, Chantal Bougneres1, Pascal Bennet1, Xavier Le Loe¨t 1, Olivier Vittecoq1, Alain Daragon*1. 1Rheumatology Department, France, 2Rheumatology Department, France Disclosures: Alain Daragon, None

OSTEOPOROSIS TREATMENT (CLINICAL): GONADAL STEROIDS AND SERMS MO0438

Antioxidant Enzyme Genes’ Polymorphisms Influence Raloxifene Therapy Outcome in Postmenopausal Osteoporosis Simona Jurkovic Mlakar1, Andrej Zavratnik2, Tomaz Kocjan3, Janez Prezelj4, Janja Marc*1. 1Department for Clinical Biochemistry, Faculty of Pharmacy, Slovenia, 2 Department of Endocrinology & Diabetes, University Medical Centre Maribor, Slovenia, 3 University of Ljubljana, Medical Faculty, Slovenia, 4Medical faculty, University of Ljubljana, Slovenia Disclosures: Janja Marc, None

274

OSTEOPOROSIS TREATMENT (CLINICAL): HEALTH ECONOMICS MO0439

Decomposing Health Care Expenditures Relative to Fractures Meredith Kilgore*1, David Becker2, Jeffrey Curtis 2, Kenneth Saag2, Elizabeth Delzell2, Tarun Arora3, Michael Morrisey2. 1University of Alabama At Birmingham School of Public Health, USA, 2University of Alabama at Birmingham, USA, 3UAB School of Public Health, USA Disclosures: Meredith Kilgore, Amgen, 5; Amgen, 2

MO0440

Fracture Liaison Service in a Non-regional Orthopaedic Clinic - A Cost-effective Service Joe O Beirne1, John Quinlan1, Isweri Pillay2, Mohamed Ahmed*2. 1Waterford Regional Hospital, Ireland, 2South Tipperary General Hospital, Ireland Disclosures: Mohamed Ahmed, None

MO0441

Healthcare Costs for Males After Closed Fracture in Commercially Insured and Medicare Advantage Populations From a National Health Plan Susan Brenneman 1, Laura Christensen1, Nicole Yurgin*2, Ying Fan1. 1Innovus, USA, 2 Amgen Inc, USA Disclosures: Nicole Yurgin, United Health Group, 3

OSTEOPOROSIS TREATMENT (CLINICAL): OTHER AGENTS MO0442

A Phase 3 Study of the Efficacy and Safety of Denosumab in Men With Low Bone Mineral Density: Design of the ADAMO Trial Eric Orwoll*1, Christence Stubbe Teglbjærg2, Bente Langdahl3, Roland Chapurlat4, Edward Czerwinski 5, David L Kendler 6, Jean-Yves Reginster7, Alan Kivitz8, E. Michael ¨ sten Ljunggren13, Bo Lewiecki9, Paul Miller 10, Michael A Bolognese11, Henry G Bone12, O Abrahamsen14, Yu-Ching Yang15, Andreas Grauer15, Cesar Libanati15, Jesse W Hall 15, Steven Boonen16. 1Oregon Health & Science University, USA, 2Centre for Clinical & Basic Research, Denmark, 3Aarhus University Hospital, Denmark, 4Hoˆpital Edouard Herriot, France, 5Krakow Medical Center, Poland, 6University of British Columbia, Canada, 7 University of Lie`ge, Belgium, 8Altoona Center for Clinical Research, USA, 9New Mexico Clinical Research & Osteoporosis Center, USA, 10Colorado Center for Bone Research, USA, 11Bethesda Health Research Center, USA, 12Michigan Bone & Mineral Clinic, USA, 13 Uppsala University, Sweden, 14University of Southern Denmark & Gentofte Hospital, Denmark, 15Amgen Inc., USA, 16Leuven University, Belgium Disclosures: Eric Orwoll, Eli Lilly, Amgen, and Merck, 2; Eli Lilly, Merck, Amgen, and Wright Medical Technology, 5

MO0443

Association Between Polymorphisms In Wnt Antagonist Genes and Bone Response to Hormone Therapy In Postmenopausal Korean Women Jung-Gu Kim*1, Hoon Kim2, Dong Ock Lee3, Seung-Yup Ku3, Seok Hyun Kim3, Young Min Choi3. 1Seoul National University Hospital, South Korea, 2Department of Obstetrics & Gynecology, Incheon Medical Center, South Korea, 3Department of Obstetrics & Gynecology, College of Medicine, Seoul National University, South Korea

MO0444

Combined Effect of Calcitonin with Risedronate for Osteoporotic Patients with Chronic Back Pain Michio Hongo*1, Naohisa Miyakoshi2, Yuji Kasukawa2, Yoshinori Ishikawa 3, Yoichi Shimada3. 1Akita University School of Medicine, Japan, 2Akita University Graduate School of Medicine, Japan, 3Akita University, Japan Disclosures: Michio Hongo, None

MO0445

First Experiences with Denosumab in Patients with Painful Disabling Transient Regional Osteoporosis (TRO) of the Hip Johann D. Ringe*, Parvis Farahmand. Medizinische Klinik 4 (Rheumatology, Osteology) & West German Osteoporosis Center (WOC), Klinikum Leverkusen, University of Cologne, Germany Disclosures: Johann D. Ringe, None

275

Monday

Disclosures: Jung-Gu Kim, None

MO0446

Good Vibrations: A Short Term Pilot Study of Low Magnitude Vibration Therapy in Patients with Thalassemia Catherine Gariepy*1, Dru Haines, PNP1, Ashutosh Lal, MD 1, Ellen Fung2. 1Children’s Hospital & Research Center Oakland, USA, 2Children’s Hospital & Research Center, Oakland, USA Disclosures: Catherine Gariepy, None

MO0447

Lycopene Does Not Alter Bone Turnover In a Healthy Population of Men and Women - An Intervention Study Claire Macdonald*1, David Reid1, Frank Thies1, Helen Macdonald 2. 1University of Aberdeen, United Kingdom, 2University of Aberdeen Bone & Musculoskeletal Research Programme, United Kingdom Disclosures: Claire Macdonald, None

MO0448

Oxidative Stress and the Risk of Osteoporosis: the Role of Dietary Polyphenols and Nutritional Supplements in Postmenopausal Women Nancy Kang*1, Venketeshwer Rao2, Katrine De Asis2, Loren Chan3, Leticia Rao1. 1 University of Toronto, St. Michael’s Hospital, Canada, 2University of Toronto, Canada, 3 St. Michael’s Hospital, Canada Disclosures: Nancy Kang, None

MO0449

The Impact of Vitamin K Therapy on Bone Metabolic Markers in Severe Motor and Intellectual Disabilities Akiko Kuwabara*1, Akiko Nagae2, Naoko Tsugawa3, Mari Kitagawa2, Kunihiko Tozawa4, Hiroaki Kohno5, Masakazu Miura6, Toshio Okano3, Masao Kumode2, Kiyoshi Tanaka7. 1Osaka Shoin Women’s University, Japan, 2Biwako Gakuen Kusatsu Medical & Welfare Center, Japan, 3Kobe Pharmaceutical University, Japan, 4EIDIA Co. Ltd., Japan, 5 Orthopaedics, Japan, 6Hokuriku University, Japan, 7Kyoto Women’s University, Japan Disclosures: Akiko Kuwabara, None

MO0450

The Potential Effect of Calcitonin in Osteoporotic Patients with Diabetic Peripheral Neuropathy Shen Qu*1, Ran Cui2, Xiaoyun Cheng3, Peng Yang4, Hui Sheng5. 1Tongji University School of Medicine, Peoples Republic of China, 2Tenth People’s Hospital of Tongji University, Peoples Republic of China, 3Department of Endocrinology, China, 4, 5 Shanghai, Fudan University, Peoples Republic of China Disclosures: Shen Qu, None

OSTEOPOROSIS TREATMENT (CLINICAL): QUALITY OF LIFE MO0451

A Novel Technique for Cement Augmentation of Pedicle Screws Reduces Cement Leakage Rates. A Prospective, Controlled, Clinical Trial in Osteoporotic Bone. Thomas Blattert*. Orthopaedische Fachklinik Schwarzach, Deu Disclosures: Thomas Blattert, AOSpine, DePuy, Medtronic, Synthes, 5

MO0452

Methods to Simplify Recruiting for Pragmatic Clinical Trials (PCTs) in Osteoporosis in the Community: iPad vs. Interactive Voice Response (IVRS) Systems Amy Mudano*1, Lisa Gary1, Mary Melton1, Amy Warriner2, T. Michael Harrington1, Meredith Kilgore3, Penelope Jester1, Nicole Wright1, Jeffrey Curtis1, Cora Lewis1, Elizabeth Delzell 1, Kenneth Saag1. 1University of Alabama At Birmingham, USA, 2UAB, USA, 3University of Alabama At Birmingham School of Public Health, USA Disclosures: Amy Mudano, None

276

OSTEOPOROSIS TREATMENT (CLINICAL): VITAMIN D AND METABOLITES MO0453

How Can We Improve Bone Health in the Long-term Care Setting? Lessons from the ViDOS study Courtney Kennedy*1, Alexandra Papaioannou2, George Ioannidis 1, Lora Giangregorio3, Sharon Marr1, Suzanne Morin4, Lehana Thabane1, Robert Josse5, Richard Crilly6, Laura Pickard1, Susanne King1, Mary-Lou van der Horst1, Ruth McCallum1, Glenda Campbell7, Jackie Stroud7, Lisa Dolovich1, Anna Sawka8, Lynne Lohfeld1, Jonathan Adachi9. 1 McMaster University, Canada, 2Hamilton Health Sciences, Canada, 3University of Waterloo, Canada, 4McGill University Health Centre, Canada, 5St. Michael’s Hospital, University of Toronto, Canada, 6University of Western Ontario, Canada, 7Medical Pharmacies Group Limited, Canada, 8Toronto General Hospital, Canada, 9St. Joseph’s Hospital, Canada Disclosures: Courtney Kennedy, None

MO0454

Serum 25-hydroxyvitamin D in Rural and Urban Postmenopausal Women Irina Haller*1, Diane Krueger2, Jean A Engelke2, Neil Binkley3. 1Essentia Institute of Rural Health, USA, 2University of Wisconsin, Madison, USA, 3University of Wisconsin, USA Disclosures: Irina Haller, None

MO0455

Solitary Calcium Supplementation in Alendronate Treated Postmenopausal Women with Low Bone Mass Does Not Prevent Secondary Hyperparathyroidism Sufficiently Oliver Bock*1, Hendrikje Bo¨rst1, Heinz-Ju¨rgen Roth2, Martin Runge3, Ze’ev Mazor4, Erich Schacht5, Peter Martus6, Dieter Felsenberg1. 1Charite´ - Campus Benjamin Franklin, Centre for Muscle & Bone Research, Germany, 2Labor Dr. Limbach und Kollegen, Medizinisches Versorgungszentrum, Germany, 3Aerpah Kliniken Esslingen-Kennenburg, Germany, 4Teva Pharmaceuticals Industries Global Products Division, Israel, 5Pharma Consulting, Switzerland, 6Charite´ - Campus Benjamin Franklin, Institute for Biometrics & Clinical Epidemiology, Germany Disclosures: Oliver Bock, Teva Deutschland GmbH, Germany, 8

MO0456

The Relationship Between Serum Vitamin D Levels and Bone Histomorphometry In Elderly Patients with Hip Fracture Abbas Ismail*1, Anthony Freemont2, Nicky Makepeace1, Stockport Bone Group1. 1 Stockport NHS Trust, United Kingdom, 2University of Manchester, United Kingdom Disclosures: Abbas Ismail, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): ANABOLIC AGENTS MO0457

Effects of Adenosine Triphosphate (ATP) on Bone and Fat Metabolism Solveig Petersen*, Susanne Syberg, Peter Schwarz, Niklas Jorgensen. Copenhagen University Hospital Glostrup, Denmark Disclosures: Solveig Petersen, None

Enhanced Peri-Implant Bone Formation and Fixation by Sclerostin Antibody in a Rat Ovariectomy Model Amarjit Virdi*1, Kotaro Sena1, Min Liu2, Hua Zhu Ke3, D. Rick Sumner1. 1Rush University Medical Center, USA, 2Amgen, USA, 3Amgen, Inc., USA

Monday

MO0458

Disclosures: Amarjit Virdi, Amgen Inc., 2 MO0459

Growth Hormone Partly Counteracts Immobilisations-induced Bone and Muscle Loss Marie-Claire Grubbe1, Jesper Thomsen2, Annemarie Bru¨el* 2. 1Aarhus University, Denmark, 2University of Aarhus, Denmark Disclosures: Annemarie Bru¨el, None

MO0460

Osteogenic Effects of Black Bear PTH (1-84) in a Mouse Model of Duchenne Muscular Dystrophy Sarah Gray*1, Meghan McGee-Lawrence2, Samantha Wojda1, Seth Donahue3. 1Michigan Technological University, USA, 2Mayo Clinic, USA, 3Michigan Tecnological University, USA Disclosures: Sarah Gray, None

277

MO0461

Sclerostin Antibody Enhances Spine Fusion in a Rat Posterolateral Transverse Process Fusion Model: Preliminary Results Andre Shaffer*1, Owolabi A Shonuga1, Brandon Hirsch2, Matthew E Cunningham 3, Jeffrey E Mait4, Chaoyang Li5, Hua Zhu Ke6, Joseph Lane3. 1Hospital For Special Surgery / Weill Cornell Medical College, USA, 2Hospital for Special Surgery / Yale University School of Medicine, USA, 3Hospital for Special Surgery, USA, 4Hospital for Special Surgery / SUNY Downstate Medical Center, USA, 5Amgen, Incorporated, USA, 6Amgen, Inc., USA Disclosures: Andre Shaffer, None

MO0462

Sclerostin Antibody Increases Peri-implant Bone Formation in Sham-ovariectomized and Ovariectomized Rats John Irish*1, Amarjit Virdi 2, Kotaro Sena2, Min Liu3, Hua Zhu Ke4, D. Rick Sumner2. 1 Rush University, USA, 2Rush University Medical Center, USA, 3Amgen, USA, 4Amgen, Inc., USA Disclosures: John Irish, NIH, 2

MO0463

Smurf Inhibition Does Not Increase Bone Mass Ina Kramer1, Janet Dawson-King1, Rohan Beckwith2, Rene Lattmann1, Nils Ostermann1, Marcel JJ Blommers1, Ji-Hu Zhang2, Michael Kiffe1, Alex Shih-Min Huang2, Michaela Kneissel1, Sabine Guth-Gundel* 1. 1Novartis Institutes for BioMedical Research, Switzerland, 2Novartis Institutes for Biomedical Research, USA Disclosures: Sabine Guth-Gundel, Novartis, 3

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): BISPHOSPHONATES MO0464

Comparison of Zoledronic Acid and Teriparatide Effects on Iliac Bone Microarchitecture, Remodeling and Collagen Crosslinks in Ewes Nathalie R Portero-Muzy* 1, Pascale M Chavassieux 2, Mary L Bouxsein3, Evelyne Gineyts 1, Roland D Chapurlat1. 1INSERM, UMR1033, Universite´ de Lyon, France, 2 INSERM UMR1033, Universite´ de Lyon, France, 3Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center & Harvard Medical School, USA Disclosures: Nathalie R Portero-Muzy, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): CALCIUM AND DIETARY FACTORS MO0465

Effect of Timing of Post-Exercise Carbohydrate and Protein Ingestion on Markers of Bone Turnover Julie Greeves*1, Ricardo Costa2, Neil Walsh3, Craig Sale4, Ruth Hobson4, John Dutton5, William Fraser 5. 1HQ Army Recruiting & Training Division, United Kingdom, 2Coventry University, United Kingdom, 3Bangor University, United Kingdom, 4Nottingham Trent University, United Kingdom, 5University of Liverpool, United Kingdom Disclosures: Julie Greeves, None

MO0466

Effects of Dietary Coral Calcium and Zeolite on Ovariectomy Induced Bone Loss Jameela Banu*1, Erika Varela1, Ganesh Halade1, Ali Bahadur1, Kokichi Hanaoka 2, Gabriel Fernandes3. 1University of Texas Health Science Center at San Antonio, USA, 2 Bio-REDOX Laboratory Inc, Japan, 3University of Texas Health Science Centre, USA Disclosures: Jameela Banu, None

MO0467

Soy Isoflavones, Alone or in Combination with Risedronate, Do Not Reduce Bone Resorption in Ovariectomized Rats Emily Hohman*, George McCabe, Connie Weaver. Purdue University, USA Disclosures: Emily Hohman, None

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): GONADAL STEROIDS AND SERMS MO0468

Estradiol Release Kinetics Determine Tissue Response in Ovariectomized Rats and Mice Ingrid Kantner*1, Christiane Otto2, Reinhard Nubbemeyer 2, Jenny Schkoldow2, Iris Fuchs2, Elisabeth Krahl2, Richardus Vonk 2, Christiane Schu¨ler 1, Karl-Heinrich Fritzemeier 2, Reinhold Erben1. 1University of Veterinary Medicine, Austria, 2Bayer Schering Pharma AG, Germany Disclosures: Ingrid Kantner, None

278

OSTEOPOROSIS TREATMENT (PRE-CLINICAL): OTHER AGENTS MO0469

Callus Resolution and Fracture Healing is Not Hindered in Cathepsin-K Null Mice Michael Gentile*1, Do Soung2, Gregg Wesolowski3, Pavithra Ramakrishnan3, Carlyle Horrell3, Hicham Drissi2, Le Thi Duong4. 1Merck & Co, USA, 2University of Connecticut Health Center, USA, 3Merck & Co., Inc., USA, 4Merck Research Laboratories, USA Disclosures: Michael Gentile, None

MO0470

Cellular and Molecular Mechanisms of Accelerated Fracture Healing By Cox-2 Gene Therapy. Studies In A Multiple Fracture Mouse Model Vishal Kothari1, Xiaobing Zhang2, K.H. William Lau 3, David Baylink2, Amitava Das*2. 1 Loma Linda University School of Medicine, USA, 2Loma Linda University, USA, 3Loma Linda Univesity School of Medicine, USA Disclosures: Amitava Das, None

MO0471

Combined Effect of Methylprednisolone and Fish Oil RX Against Bone Mineral Density Loss in Spontaneous Autoimmune Disease Prone MRL-lpr/lpr Mice Md Rahman*1, Paul Williams2, Kazi Nishu2, Gabriel Fernandes2. 1University of Texas Health Science Center, USA, 2University of Texas Health Science Centre, USA Disclosures: Md Rahman, None

MO0472

Comparison of the Efficacy of Odanacatib or Alendronate on Bone Remodeling and Biomechanical Properties of the Lumbar Spine in Estrogen-deficient Rhesus Monkeys Brenda Pennypacker*1, Charles Chen2, Ya Zhuo2, Maureen Pickarski2, Le Thi Duong1. 1 Merck Research Laboratories, USA, 2Merck & Co., Inc., USA Disclosures: Brenda Pennypacker, None

MO0473

Effects of Herb Extracts on Osteoclasts, Osteoblasts and Chondrocytes as Novel Drug Candidates for Osteoporosis Seika Banka1, Satoru Shintani1, Kazunaga Yazawa2, Kondo Seiji1, Yoshiki Mukudai*3. 1 Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University, Japan, 2Laboratory of Nutraceuticals & Functional Foods Science, Graduate School Marine Science & Technology, Tokyo University of Marine Science & Technology, Japan, 3 Showa University, Japan Disclosures: Yoshiki Mukudai, None

STEROID HORMONES AND RECEPTORS: CALCIUM-SENSING RECEPTORS MO0474

Calcium-Sensing Receptor Mediated Suppression of cAMP by Agonists and Allosteric Modulators Vimesh Avlani*1, Arthur Conigrave2. 1University of Sydney, Aus, 2University of Sydney, Australia Disclosures: Vimesh Avlani, None

Alpha-2-Macroglobulin as a Biomarker for Glucocorticoid-induced Osteonecrosis of the Femoral Head Alberto Carli 1, Edward J Harvey2, Mireille Sayegh1, Bouziane Azeddine* 1, Ailian Li 3, Ayoub Nahal2, Rene´ Michel 2, Janet E Henderson3, Chantal Se´guin 2. 1McGill University, Canada, 2McGill University Health Centre, Canada, 3McGill University Health CentreResearch Institute, Canada Disclosures: Bouziane Azeddine, None

MO0476

ROS, FoxOs, and Akt are Critical Mediators of the Actions of both Glucocorticoids and TNFa on Osteoblastic Cells Maria Almeida*, Li Han, Elena Ambrogini, Shoshana Bartell, Srividhya Iyer, Aaron Warren, Charles O’Brien, Robert Jilka, Robert Weinstein, Stavros Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Maria Almeida, None

279

Monday

STEROID HORMONES AND RECEPTORS: GLUCOCORTICOIDS MO0475

STEROID HORMONES AND RECEPTORS: SEX STEROIDS MO0477

A Moderate Oral Dose of Mixed Isoflavones Was Most Effective at Reducing Bone Resorption in Postmenopausal Women Jessica Wiersma*1, Berdine Martin1, George McCabe1, Linda McCabe1, George Jackson1, Munro Peacock2, Stephen Barnes3, Connie Weaver1. 1Purdue University, USA, 2Indiana University Medical Center, USA, 3University of Alabama, USA Disclosures: Jessica Wiersma, None

MO0478

DNA Binding Mutations in ERa Lead to Suppression of Wnt Signaling in Bone Ulrike Moedder1, Sundeep Khosla2, David Monroe*3. 1United Kingdom, 2College of Medicine, Mayo Clinic, USA, 3Mayo Foundation, USA Disclosures: David Monroe, None

MO0479

Estrogen Protects Against Arthritis and Inflammation-Mediated Bone Loss Via Estrogen Receptor Alpha Cecilia Engdahl1, Anna Borjesson2, Ulrika Islander3, Sara Windahl4, Alexandra Stubelius3, Annica Andersson 3, Andre´e Krust5, Pierre Chambon5, Claes Ohlsson2, Hans Carlsten3, Marie Lagerquist* 6. 1Centre for Bone & Arthritis Researc, GU, Sauhlgrenska Academy, Medicine, Sweden, 2Centre for Bone & Arthritis Research, Sweden, 3Center for Bone & Arthritis Research, Sahlgrenska Academy, Sweden, 4Center for Bone & Arthritis Research, Sweden, 5Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire (CNRS UMR7104; INSERM U596; ULP, Colle`ge de France), France, 6Sahlgrenska University Hospital, Sweden Disclosures: Marie Lagerquist, None

MO0480

Estrogen Response Element Binding Protein is a Multi-Site Regulator in Bone Cells at the Level of Chromatin Remodeling, Transcription and mRNA Handling Hong Chen*1, Linda Gilbert2, Thomas Lisse3, Martin Hewison4, Mark Nanes5, John Adams6. 1VA / Emory University School of Medicine, USA, 2VA medical Center at Atlanta, USA, 3UCLA/Orthopaedic Hospital Research Center, USA, 4UCLA, USA, 5VA Medical Center & Emory University, USA, 6University of California, Los Angeles, USA Disclosures: Hong Chen, None

STEROID HORMONES AND RECEPTORS: VITAMIN D AND ITS ANALOGS MO0481

1, 25-dihydroxyvitamin D Inhibits Growth and Induces Apoptosis of Breast Cancer Stem Cells Jiarong Li*1, Jing Lian1, Richard Kremer2. 1McGill University, Canada, 2McGill University, Royal Victoria Hospital, Canada Disclosures: Jiarong Li, None

MO0482

25-Hydroxyvitamin D, Parathyroid Hormone and Muscle Relationships in Early Pubertal Adolescents Jamie Williams1, Ashley Ferira2, Emma Laing*1, Dorothy Hausman1, Connie Weaver3, Munro Peacock4, Kathleen Hill 5, Berdine Martin3, Stuart Warden6, Norman Pollock7, Richard Lewis1. 1The University of Georgia, USA, 2University of Georgia, USA, 3Purdue University, USA, 4Indiana University Medical Center, USA, 5Indiana University School of Medicine, USA, 6Indiana University, USA, 7Georgia Health Sciences University, USA Disclosures: Emma Laing, None

MO0483

Associations between Serum Vitamin D, Cardiometabolic Risk Factors and Visceral Adiposity in Obese Children Ashley Ferira*1, Norman Pollock2, Emma Laing3, Dorothy Hausman1, Yanbin Dong2, Richard Lewis3, Catherine L. Davis2. 1University of Georgia, USA, 2Georgia Health Sciences University, USA, 3The University of Georgia, USA Disclosures: Ashley Ferira, None

MO0484

Co-expression of Human hnRNPC1 and C2 Suppresses Vitamin D Receptor-mediated Transcriptional Responses in Mouse Osteoblastic Cells Thomas Lisse*1, Rene Chun2, John Adams3, Martin Hewison 4. 1UCLA/Orthopaedic Hospital Research Center, USA, 2Orthopedic Hospital Research Center, UCLA, USA, 3 University of California, Los Angeles, USA, 4UCLA, USA Disclosures: Thomas Lisse, None

280

MO0485

Comparison of Two Fully Automated Total 25 Vitamin D Immunoassays Heather Pham*1, Benny Larsson2. 1Immunodiagnostic Systems, United Kingdom, 2 Universitetssjukhuset i Malmo¨, Sweden Disclosures: Heather Pham, Immunodiagnostic System, 3

MO0486

Effect of Growth Factors on Vitamin D Receptor and its Role in Vitamin D-Mediated Growth Suppression in Porcine Coronary Artery Smooth Muscle Cells Gaurav Gupta* 1, Tanupriya Agrawal1, Devendra Agrawal2. 1Creighton University, USA, 2 Creighton University School of Medicine, USA Disclosures: Gaurav Gupta, None

MO0487

Prevalence of Vitamin D Deficiency and Its Relationship with Sun Exposure and Skin Phototype in Elderly Men Living in the Tropics marcelo cabral1, carla borges1, Daniele Fontan2, Leonardo Bandeira1, NARRIANE CHAVES1, Francisco Bandeira*3. 1doctor(MD), Brazil, 2Brazil, 3UPE, Brazil Disclosures: Francisco Bandeira, None

MO0488

Similar Vitamin D2 and D3 Pharmacokinetics with a Single and Daily Doses Silvina Mastaglia*1, Mariana Seijo 2, Graciela Brito3, Guillermo Keller 4, Julia Somoza 5, Roberto Diez4, Guillermo Di Girolamo4, Beatriz Oliveri5. 1Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Consejo Nacional de Investigaciones Cientı´ficas y Tecnolo´gicas (CONICET), Argentina, 2Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires, Argentina, 3Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Agencia Nacional de Promocio´n Cientı´fica y Tenolo´gica (ANPCyT), Argentina, 42 ˚ Ca´tedra de Farmacologı´a, Facultad de Medicina, Universidad de Buenos Aires, Argentina, 5Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires.Consejo Nacional de Investigaciones Cientı´ficas y Tecnolo´gicas (CONICET), Argentina Disclosures: Silvina Mastaglia, None

MO0489

State of the Art of Vitamin D Assays: Latest Generation Assays Christopher-John Farrell1, Steven Martain2, Isabella Straub3, Paul Williams4, Markus Herrmann*4. 1PaLMS & Laverty Pathology, Australia, 2Laverty Pathology, Australia, 3 University of Sydney, Australia, 4Royal Prince Alfred Hospital & University of Sydney, Australia Disclosures: Markus Herrmann, None

MO0490

Disclosures: Clarisa Marotte, None

MEET-THE-PROFESSOR SESSIONS 1:30 pm - 2:30 pm

Rooms 24A-27A

Osteoprogenitor Development and Differentiation Room 24A Paolo Bianco, M.D. Universita La Sapienza, Italy Disclosures: Paolo Bianco, None

281

Monday

Vitamin D Supplementation does not Change Expression of Human Cathelicidin in Neutrophils in Young Healthy Subjects. Silvina Mastaglia1, Clarisa Marotte*2, Gabriel Bryk3, Julia Somoza1, Graciela Brito4, Mariana Seijo3, Marı´a Fornari5, Roberto Diez6, Beatriz Oliveri1. 1Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. National Council for Scientific & Technologic Research (CONICET), Argentina, 2Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. National Council for Scientific & Technologic Research ( CONICET)., Argentina, 3Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires, Argentina, 4Seccio´n Osteopatı´as Me´dicas, Hospital de Clı´nicas, Universidad de Buenos Aires. Agencia Nacional de Promocio´n Cientı´fica y Te´conologica (ANPCyT), Argentina, 5Laboratorio de Ana´lisis Clı´nicos Fornari Bioalpha SA, Buenos Aires, Argentina, 62 ˚ Ca´tedra de Farmacologı´a, Facultad de Medicina, Universidad de Buenos Aires, Argentina

Activins and Inhibins in Musculoskeletal Health Room 24B Dana Gaddy, Ph.D. University of Arkansas for Medical Sciences, USA Disclosures: Dana Gaddy, None

Human iPS Cells In Musculoskeletal Research Room 24C Alexander Lichtler, Ph.D. University of Connecticut Health Center, USA Disclosures: Alexander Lichtler, None

Peak Bone Mass and Assessing Bone Density in Children Room 25A Laura K. Bachrach, M.D. Stanford University School of Medicine, USA Disclosures: Laura Bachrach, None

Micronutrients and Bone Room 25B Connie M. Weaver, Ph.D. Purdue University, USA Disclosures: Connie Weaver, Tate & Lyle 2; Dairy Management Inc 2; Nestle 2; Pharmavite 99

Managing Bone Health in Bariatric Surgery Population Room 25C Shonni J. Silverberg, M.D. Columbia University, USA Disclosures: Shonni Silverberg, None

Vascular and Valvular Calcification Room 26A Linda L. Demer, M.D., Ph.D. David Geffen School of Medicine At University of California Los Angeles, USA Disclosures: Linda Demer, None

Nalini M. Rajamannan, M.D. Northwestern University Medical School, USA Disclosures: Nalini Rajamannan, None

ADVOCATING FOR SCIENCE IN CHALLENGING TIMES 1:30 pm - 2:30 pm Co-Chairs Paula H. Stern, Ph.D. Northwestern University Medical School, USA Disclosures: Paula Stern, None

Mark L. Johnson, Ph.D. University of Missouri, Kansas City Dental School, USA Disclosures: Mark Johnson, None

1:30 pm

Introduction Mark L. Johnson, Ph.D. University of Missouri, Kansas City Dental School, USA Disclosures: Mark Johnson, None

1:35 pm

NIH Funding Challenges and Opportunities Lawrence A. Tabak, D.D.S., Ph.D. Principal Deputy Director, National Institutes of Health, USA Disclosures: Lawrence Tabak, None

1:55 pm

Importance of Advocating for Funding and Strategies to Succeed Hon. John E. Porter, Chairman Research!America, USA Disclosures: Hon. John Porter, None

282

Room 20A

2:15 pm

What can Bone Researchers Do? Paula H. Stern, Ph.D. Northwestern University Medical School, USA Disclosures: Paula Stern, None

2:20 pm

Panel Discussion and Q&A

CLINICAL ROUNDTABLE/CASE CONFERENCE - MONITORING OSTEOPOROSIS THERAPY – TO SCAN OR NOT TO SCAN? Supported by an Educational Grant from Lilly USA, LLC 1:30 pm - 2:30 pm

Room 20BCD

Chair Deborah E. Sellmeyer, M.D. The Johns Hopkins Bayview Medical Center, USA Disclosures: Deborah Sellmeyer, Novartis, Inc. 5

1:30 pm

Douglas C. Bauer, M.D. University of California, San Francisco, USA Disclosures: Douglas Bauer, None

2:00 pm

Nelson B. Watts, M.D. University of Cincinnati Bone Health and Osteoporosis Center, USA Disclosures: Nelson Watts, Warner Chilcott 5; Orexigen 5; Vivus 5; Merck 5; Eli Lilly 5; Warner Chilcott 8; Baxter 5; NPS 5; Pfizer/Wyeth 5; Takeda 5; Arena 5; Novartis 8; Imagepace 5; Amgen 5; Medpace 5; OsteoDynamics 1; InteKrin 5; Johnson & Johnson 5; Amgen 8

CONCURRENT ORAL SESSION 31: GENETIC DISORDERS OF BONE AND MINERAL METABOLISM 2:45 pm - 4:15 pm

Room 30CDE

Moderators: Steven Mumm, Ph.D. Washington University School of Medicine, USA Disclosures: Steven Mumm, None

Cheryl L. Ackert-Bicknell, Ph.D. The Jackson Laboratory, USA Disclosures: Cheryl Ackert-Bicknell, None

Sc65 is a Novel Regulator of Bone Homeostasis Brittany Hendrix1, Katrin Gruenwald 1, Patrizio Castagnola 2, Dana Gaddy1, Larry Suva1, Roy Morello* 1. 1University of Arkansas for Medical Sciences, USA, 2National Institute for Cancer Research, Italy Disclosures: Roy Morello, None

3:00 pm 1182

Aberrant Osteoblast and Osteoclast Activity in Connexin43 G60S Missense Mutant Mice Leads to Age-related Bone Anomalies Tanya Zappitelli*1, Frieda Chen1, Marc Grynpas2, Janet E. Henderson3, Luisa Moreno2, Ralph Zirngibl1, Jane Aubin4. 1University of Toronto, Canada, 2Samuel Lunenfeld Research Institute, Canada, 3McGill University, Canada, 4University of Toronto Faculty of Medicine, Canada Disclosures: Tanya Zappitelli, None

3:15 pm 1183

Modeling Skeletal Diseases in iPS Cells Edward Hsiao*1, Yohei Hayashi2, Trieu Nguyen2, Sahar Tahari2, Matthew Spindler2, Christopher Schlieve2, Salma Sami2, Shinya Yamanaka2, Bruce Conklin2, Robert Nissenson 3. 1University of California, San Francisco, USA, 2Gladstone Institute of Cardiovascular Disease, USA, 3VA Medical Center & University of California, San Francisco, USA Disclosures: Edward Hsiao, None

283

Monday

2:45 pm 1181

3:30 pm 1184

2011 ASBMR YOUNG INVESTIGATOR AWARD Increased Levels of TAF12 with IL-6 Can Substitute for MVNP to Induce Pagetic-Osteoclasts Jumpei Teramachi*1, Jolene Windle2, Noriyoshi Kurihara1, G. David Roodman3. 1 University of Pittsburgh & The Center for Bone Biology at UPMC, USA, 2Virginia Commonwealth University, USA, 3University of Pittsburgh, The Center for Bone Biology at UPMC, & VA Pittsburgh Healthcare System, USA Disclosures: Jumpei Teramachi, None

3:45 pm 1185

Sclerostin Antibody Improves Bone Mass and Mechanical Properties in an Adult Brtl/+ Model of Osteogenesis Imperfecta Benjamin Sinder*1, Logan White1, Michelle Caird1, Joan Marini2, Kenneth Kozloff3. 1 University of Michigan, USA, 2National Institute of Child Health & Human Development, USA, 3University of Michigan Department of Orthopaedic Surgery, USA Disclosures: Benjamin Sinder, None

4:00 pm 1186

Genetic Deletion of Osteopontin Restores Unloading Mediated Bone Loss in a NF1 Murine Model Ping Zhang*1, Shi Chen2, Yongzheng He2, Xiaohua Wu 2, Steven D. Rhodes2, Xianlin Yang2, Jin Yuan2, Li Jiang2, Feng-Chun Yang2. 1Indiana University, School of Medicine, USA, 2Indiana University School of Medicine, USA Disclosures: Ping Zhang, None

CONCURRENT ORAL SESSION 32: OSTEOCLASTS 2:45 pm - 4:15 pm

Room 29ABCD

Moderators: Timothy J. Chambers, M.D. St. George’s Hospital Medical School, United Kingdom Disclosures: Timothy Chambers, None

Charles A. O’Brien, Ph.D. University of Arkansas for Medical Sciences, USA Disclosures: Charles O’Brien, None

2:45 pm 1187

2011 ASBMR YOUNG INVESTIGATOR AWARD Targeting of the DAP12-associated, Osteoclast-specific Receptor Siglec-15 by Antibody 25E9 Inhibits Differentiation and Resorption Activity MATTHEW STUIBLE*, Annie Fortin, Elisabeth Viau, Marc Sasseville, Aida Kalbakji, Anna Moraitis, Mario Filion, Gilles Tremblay. Alethia Biotherapeutics, Canada Disclosures: MATTHEW STUIBLE, Alethia Biotherapeutics, 3

3:00 pm 1188

Knockin Mice Bearing an Inactivating Mutation in the RANK IVVY Motif Exhibit Increased Bone Mass Due to Impaired Osteoclastogenesis Zhenqi Shi*, Joel Jules, Bob Kesterson, Xu Feng. University of Alabama at Birmingham, USA Disclosures: Zhenqi Shi, None

3:15 pm 1189

Targeted FoxO3 Overexpression in Osteoclast Progenitors and Mature Osteoclasts Inhibits NF-Kb Signaling and Osteoclastogenesis and Increases Bone Mass Shoshana M. Bartell*, Elena Ambrogini, Li Han, Aaron Warren, Randal S. Shelton, Haibo Zhao, Xiahua Qiu, Joseph Goellner, Charles A. O’Brien, Maria Jose S. Almeida, Stavros C. Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Shoshana M. Bartell, None

3:30 pm 1190

Comprehensive Epigenetic Analysis Reveals Nedd9 is a Key Downstream Molecule of TGF-b Involving in RANKL-Induced Osteoclastogenesis Yasunori Omata*1, Tetsuro Yasui2, Takumi Matsumoto 1, Hironari Masuda3, Jun Hirose4, Naoto Tokuyama1, Hisataka Yasuda5, Shuichi Tsutsumi6, Aburatani Hiroyuki 6, Kozo Nakamura 1, Sakae Tanaka1. 1The University of Tokyo, Japan, 2University of Tokyo, Japan, 3The University of Tokyo, Jpn, 4The University of Tokyo, Japan, 5Oriental Yeast Company, Limited, Japan, 6Genome science Division, RCAST, Univ.Tokyo, Japan Disclosures: Yasunori Omata, None

284

3:45 pm 1191

Bone Marrow Adiposity Affects Osteoclastogenesis by Modulating the Bone Marrow Niche He Fu*1, Dominique Pierroz2, Anne Wilson3, Serge Ferrari 4, Beatrice Desvergne5. 1CIG University of Lausanne, Switzerland, 2University Hospital of Geneva, Switzerland, 3 LICR@UNIL, Switzerland, 4Geneva University Hospital & Faculty of Medicine, Switzerland, 5CIG UNIL, Switzerland Disclosures: He Fu, None

4:00 pm 1192

Lis1 Plays an Important Role in Bone Resorption by Regulating Microtubule Organization and Dynein Function in Osteoclasts Shiqiao Ye*1, Tristan Fowler1, Nathan Pavlos2, Pei Ying Ng2, Yunfeng Feng3, Ming Hao Zheng4, Richard Kurten5, Stavros Manolagas 1, Haibo Zhao1. 1University of Arkansas for Medical Sciences, USA, 2The University of Western Australia, Australia, 3Department of Internal Medicine, Washington University School of medicine, USA, 4University of Western Australia, Australia, 5Department of Physiology & Biophysics, University of Arkansas for medical Sciences, USA Disclosures: Shiqiao Ye, None

CONCURRENT ORAL SESSION 33: GROWTH FACTORS, CYTOKINES, IMMUNOMODULATORS 2:45 pm - 4:15 pm

Room 32AB

Moderators: Joy Y. Wu, M.D., Ph.D. Massachusetts General Hospital, USA Disclosures: Joy Wu, None

Matthew J. Hilton, Ph.D. University of Rochester School of Medicine, USA Disclosures: Matthew Hilton, None

2:45 pm 1193

2011 ASBMR YOUNG INVESTIGATOR AWARD IGF-1 Maintains Bone Mass by Inducing Osteoblast Differentiation of MSCs during Bone Remodeling Lingling Xian*1, Xiangwei Wu2, LIJUAN PANG2, Tao Qiu2, Frank Frassica3, Clifford Rosen4, Shouhong Xuan 5, Argiris Efstratiadis 5, Mei Wan2, Xu Cao6. 1Johns hopkins university school of Medicine, USA, 2Johns Hopkins University School of Medicine, USA, 3 Department of Orthopaedic Surgery,Johns Hopkins University School of Medicine, USA, 4 Maine Medical Center, USA, 54Medical Center of Genetics & Development, Columbia University, USA, 6Johns Hopkins University, USA Disclosures: Lingling Xian, None

3:00 pm 1194

Disclosures: Shigeki Nishimori, None

3:15 pm 1195

2011 ASBMR YOUNG INVESTIGATOR AWARD Erg and PTHrp Genetically Cooperate to Maintain Articular Cartilage Long-term Function Yoichi Ohta*1, Takahiro Okabe2, Shuji Asai 3, Motomi Enomoto-Iwamoto3, Maurizio Pacifici4, Masahiro Iwamoto5. 1Translational Research Program in Pediatric Orthopaedics, Division of Orthpaedic Surgery, Department of Surgery, The Children’s Hospital of Philadelphia Research Institute, USA, 2Department of Orthopaedic Surgery, Osaka city University, Graduate school of Medicine, Japan, 3The Children’s Hospital of Philadelphia Research Institute, USA, 4Children’s Hospital of Philadelphia, USA, 5The Children’s Hospital of Philadelphia, USA Disclosures: Yoichi Ohta, None

285

Monday

Parathyroid Hormone-related Peptide (PTHrP) Inhibits Chondrocyte Hypertrophy by Stimulating Actions of Histone Deacetylase (HDAC) 4 Shigeki Nishimori*1, Forest Lai1, Elena Kozhemyakina2, Eric Olson3, Andrew B. Lassar2, Henry Kronenberg 1. 1Massachusetts General Hospital, USA, 2Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, USA, 3UT Southwestern Medical Center At DallasDepartment of Molecular Biology, USA

3:30 pm 1196

The Heparin Binding Domain of IGFBP-2 is an Important Regulator of Murine Hematopoiesis and Human Stem Cell Proliferation Anne Breggia*1, Casey Doucette2, Masanobu Kawai1, David Clemmons 3, Clifford Rosen1. 1 Maine Medical Center, USA, 2Maine Medical Center Research Institute, USA, 3University of North Carolina, USA Disclosures: Anne Breggia, None

3:45 pm 1197

BMP4 Regulates the Hematopoietic Stem Cell Niche Size in Bone Marrow Kunikazu Tsuji*, Ichiro Sekiya, Takeshi Muneta. Tokyo Medical & Dental University, Japan Disclosures: Kunikazu Tsuji, None

4:00 pm 1198

Caspase-1 Activity is Required for Cleavage of Bone Morphogenetic Protein Receptor Type Ia and its Translocation into the Nucleus to Induce Adipogenesis Oleksandra Moseychuk*, Jeremy Bonor, Hemanth Akkiraju, Anja Nohe. University of Delaware, USA Disclosures: Oleksandra Moseychuk, None

CONCURRENT ORAL SESSION 34: ANABOLIC TREATMENT FOR OSTEOPOROSIS 2:45 pm - 4:15 pm

Room 20BCD

Moderators: Joyce H. Keyak, Ph.D. University of California, USA Disclosures: Joyce Keyak, None

Richard Eastell, M.D., FRCP University of Sheffield, United Kingdom Disclosures: Richard Eastell, None

2:45 pm 1199

Parathyroid Hormone 1-84 Accelerates Fracture Healing in Pubic Bones of Elderly Osteoporotic Women Gerold Holzer*1, PETER PEICHL2, Lukas Holzer1, Richard maier 3. 1Medical University of Vienna, Austria, 2EVANGELISCHES KRANKENHAUS VIENNA, Austria, 3 Thermenklinikum, Austria Disclosures: Gerold Holzer, None

3:00 pm 1200

Increased Trabecular Tissue Mineral Density Partially Explains the Improvement in Trabecular Volumetric BMD in Premenopausal Women with Idiopathic Osteoporosis Treated with Teriparatide Xiaowei Liu*1, Adi Cohen2, Emily Stein1, David Dempster3, Hua Zhou4, Joan Lappe5, Robert Recker5, Polly Chen3, Donald McMahon1, Elizabeth Shane1. 1Columbia University College of Physicians & Surgeons, USA, 2Columbia University Medical Center, USA, 3 Columbia University, USA, 4Helen Hayes Hospital, USA, 5Creighton University Osteoporosis Research Center, USA Disclosures: Xiaowei Liu, None

3:15 pm 1201

Effect of Weekly Teriparatide in Patients with Osteoporosis Toshitaka Nakamura*1, Toshitsugu Sugimoto2, Tetsuo Nakano3, Hideaki Kishimoto4, Masako Ito 5, Masao Fukunaga6, Hiroshi Hagino7, Teruki Sone6, Hideki Yoshikawa8, Yoshiki Nishizawa9, Masataka Shiraki10. 1University of Occupational & Environmental Health, Japan, 2Shimane University School of Medicine, Japan, 3Tamana Central Hospital, Japan, 4San-in Rosai Hospital, Japan, 5Nagasaki University Hospital, Japan, 6Kawasaki Medical School, Japan, 7Tottori University, Japan, 8Osaka University Graduate School of Medicine, Japan, 9Osaka City University Medical School, Japan, 10Research Institute & Practice for Involutional Diseases, Japan Disclosures: Toshitaka Nakamura, Teijin Pharma, 5; Chugai Pharmaceutical Co., 5; Daiichi Sankyo Co., 5; Asahi-Kasei Pharma Co., 5

286

3:30 pm 1202

Teriparatide for Premenopausal Women with Idiopathic Osteoporosis: A Paired Transiliac Bone Biopsy Study Adi Cohen*1, Emily Stein2, David Dempster 3, Robert Recker4, Joan Lappe4, Hua Zhou5, Thomas Nickolas1, Alexander Zwahlen6, Thomas Kohler6, Ralph Mu¨ller 6, Polly Chen3, Kavita Pandit3, Elizabeth Shane2. 1Columbia University Medical Center, USA, 2Columbia University College of Physicians & Surgeons, USA, 3Columbia University, USA, 4 Creighton University Osteoporosis Research Center, USA, 5Helen Hayes Hospital, USA, 6 ETH Zurich, Switzerland Disclosures: Adi Cohen, None

3:45 pm 1203

Skeletal Histomorphometry in Patients On Teriparatide or Zoledronic Acid Therapy (SHOTZ) Study: 6-Month Results of a Randomized Clinical Trial David W. Dempster* 1, Hua Zhou1, Robert R. Recker2, Jacques P. Brown3, Michael A. Bolognese4, Christopher Recknor5, David L. Kendler6, E. Michael Lewiecki7, David A. Hanley8, D. Sudhaker Rao9, Paul Miller 10, Grattan C. Woodson, III 11, Robert Lindsay1, Neil Binkley12, Xiaohai Wan13, Valerie A. Ruff13, Boris Janos14, Kathleen A. Taylor13. 1 Regional Bone Center, Helen Hayes Hospital, USA, 2School of Medicine, Creighton University, USA, 3Groupe de recherche en maladies osseuses, Layal University, Canada, 4 Bethesda Health Research, USA, 5United Osteoporosis Center, USA, 6Prohealth Clinical Research, Canada, 7New Mexico Clinical Research & Osteoporosis Center, USA, 8Heritage Medical Research Clinic, Canada, 9Henry Ford Hospital, USA, 10Colorado Center for Bone Research, USA, 11Atlanta Research Center, USA, 12University of Wisconsin, USA, 13 Lilly USA, LLC, USA, 14Eli Lilly Canada Inc., Canada Disclosures: David W. Dempster, Eli Lilly and Company, 2; Eli Lilly and Company, 5; Eli Lilly and Company, 8

4:00 pm 1204

Increases In both Vertebral and Femoral Strength In Postmenopausal Osteoporotic Women after 18 months of Treatment with Teriparatide Tony Keaveny* 1, David Kopperdahl2, Valerie Ruff3, Xiaohai Wan3, Kelly Krohn4. 1 University of California, Berkeley, USA, 2O.N. Diagnostics, USA, 3LILLY USA, LLC, USA, 4Lilly USA, USA Disclosures: Tony Keaveny, Eli Lilly and Company, 5

CONCURRENT ORAL SESSION 35: WNT PATHWAY AND OSTEOPOROSIS TREATMENT 2:45 pm - 4:15 pm

Room 20A

Moderators: G. David Roodman, M.D., Ph.D. VA Pittsburgh Healthcare System (646), USA Disclosures: G. David Roodman, None

Disclosures: Helmut Glantschnig, None

2:45 pm 1205

FoxO1 is a Transcriptional Mediator of the Regulation of Bone Formation by Circulating Serotonin Aruna Kode*1, Barbara Silva1, Ioanna Mosialou1, Charles Duncan1, Tim M Townes2, Rene Hen 3, X.Edward Guo3, Stavroula Kousteni 1. 1Columbia University Medical Center, USA, 2University of Alabama, USA, 3Columbia University, USA Disclosures: Aruna Kode, None

3:00 pm 1206

Dkk1 Inhibition Promotes Bone Formation in Growing, but Not in Aged Osteopenic Rats William G. Richards*1, Mario Grisanti2, Denise Dwyer1, Qing-Tian Niu1, Franklin Asuncion2, Marina Stolina3, Michael Ominsky2, Xiaodong Li3. 1Amgen Inc., USA, 2 Amgen, Incorporated, USA, 3Amgen Inc, USA Disclosures: William G. Richards, Amgen, Inc, 1; Amgen, Inc, 3

287

Monday

Helmut Glantschnig Merck Research Laboratories, USA

3:15 pm 1207

Sclerostin Inhibition Prevents Low Bone Mass Associated with Type 2 Diabetes Mellitus in Rats Christine Hamann*1, Yvonne Hoehna1, Martina Rauner2, Claudia Goettsch3, Klaus-Peter Guenther1, Michael Ominsky4, Lorenz Hofbauer5. 1Dresden University Medical Center, Germany, 2Medical Faculty of the TU Dresden, Germany, 3Department of Medicine III, Technical University, Dresden, USA, 4Amgen, Incorporated, USA, 5Dresden Technical University Medical Center, Germany Disclosures: Christine Hamann, None

3:30 pm 1208

Sclerostin Antibody Prevents Bone Loss and Increases Bone Formation in Female Rats with High Turnover due to Ovariectomy Xiaodong Li*1, Kelly S Warmington 2, Xue Chun Xia 3, Aly A Williams3, Mario Grisanti2, Qing-Tian Niu2, Denise Dwyer2, Marina Stolina1, Chris Paszty2, Thomas Wronski3, Hua Zhu Ke2. 1Amgen Inc, USA, 2Amgen Inc., USA, 3University of Florida, USA Disclosures: Xiaodong Li, Amgen Inc., 3; Amgen Inc., 1

3:45 pm 1209

Deletion of the Pro-Apoptotic Proteins Bax and Bak from Osteoblasts and Osteocytes Increases Bone Mass, and Retards the Loss of Cancellous Bone but Dramatically Accelerates Cortical Porosity in Aged Mice Robert Jilka*, Annick DeLoose, Leslie Climer, Stuart Berryhill, Charles O’Brien, Robert Weinstein, Stavros Manolagas. Center for Osteoporosis & Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, USA Disclosures: Robert Jilka, None

4:00 pm 1210

Inhibition of BMP Signaling Using RAP-661, a Soluble Form of BMPR1A, Increases Bone Mass in Ovariectomized Mice Aaron Mulivor*, Yoshimi Kawamoto, Ravi Kumar, Jasbir Seehra, R. Scott Pearsall, Nicolas Solban. Acceleron Pharma, USA Disclosures: Aaron Mulivor, Acceleron Pharma, 3

CONCURRENT ORAL SESSION 36: METABOLIC INFLUENCES IN THE PATHOPHYSIOLOGY OF OSTEOPOROSIS 2:45 pm - 4:15 pm

Room 31ABC

Moderators: Janet Rubin, M.D. University of North Carolina, Chapel Hill, School of Medicine, USA Disclosures: Janet Rubin, None

Kendall Moseley The Johns Hopkins Hospital, USA Disclosures: Kendall Moseley, None

2:45 pm 1211

Rosiglitazone Reduced BMD in Women with Type 2 Diabetes and the Effect was Attenuated After Switching to Metformin John P. Bilezikian1, Richard Eastell2, Antonio J. Nino3, Allison R. Northcutt3, Barbara Kravitz3, Gitanjali Paul 3, Alexander R. Cobitz3, Robert Josse4, Lorraine Fitzpatrick*5. 1 Columbia University, College of Physicians & Surgeons, USA, 2University of Sheffield, United Kingdom, 3GlaxoSmithKline Pharmaceuticals, USA, 4University of Toronto, Canada, 5GlaxoSmithKline, USA Disclosures: Lorraine Fitzpatrick, GlaxoSmithKline Pharmaceuticals, 5

3:00 pm 1212

Undercarboxylated Osteocalcin does not Predict Development of Diabetes In older Adults In the Health, Aging and Body Composition Study Ann Schwartz*1, Caren Gundberg2, Douglas Bauer1, Susan Ewing1, Eric Vittinghoff 1, Elsa Strotmeyer3, Kenneth Feingold1, Patrick Garnero4, Tamara Harris5, Alka Kanaya1, Annemarie Koster 6, Suzanne Satterfield7, Steven Cummings 8. 1University of California, San Francisco, USA, 2Yale University School of Medicine, USA, 3University of Pittsburgh, USA, 4INSERM Research Unit 664 & Cisbio Bioassays, France, 5Intramural Research Program, National Institute on Aging, USA, 6National Institutes of Health, USA, 7 University of Tennesee, USA, 8San Francisco Coordinating Center, USA Disclosures: Ann Schwartz, Merck, GlaxoSmithKline, 2; GlaxoSmithKline, Amgen, 5

288

3:15 pm 1213

Deletion of Nocturnin Protects Against Rosiglitazone-Induced But Not Age-Related Bone Loss Phuong Le*1, Anyonya Guntur1, Sheila Bornstein2, Leeann Louis3, Masanobu Kawai2, Mary Bouxsein 3, Beata Lecka-Czernik 4, Clifford Rosen2. 1Maine Medical Center Research Institute, USA, 2Maine Medical Center, USA, 3Beth Israel Deaconess Medical Center, USA, 4University of Toledo College of Medicine, USA Disclosures: Phuong Le, None

3:30 pm 1214

N-Cadherin/Wnt Signalling Interaction Controls The Switch Between Osteoblast and Adipocyte Mesenchymal Cell Differentiation In Aging Mice Eric Hay*1, Thibault Buczkowski2, Pierre Marie3. 1INSERM 4606, France, 2Inserm U606 & University Paris Diderot, France, 3INSERM Unit 606 & University Paris Diderot, France Disclosures: Eric Hay, None

3:45 pm 1215

Mice Lacking AMP-activated Proteine Kinase (AMPK)-alpha1 Catalytic Subunit have Attenuated Bone Responses to Ovariectomy and Intermittent PTH Treatment Jeshmi Jeyabalan*1, Mittal Shah1, Benoit Viollet2, Marta Korbonits3, Chantal Chenu1. 1 Royal Veterinary College, United Kingdom, 2Institut Cochin Inserm, France, 3Barts & the London Medical School, United Kingdom Disclosures: Jeshmi Jeyabalan, None

4:00 pm 1216

Altered Bone Fatty Acid Metabolism in Obesity and After Diet-Induced Weight Loss Riku Kiviranta*1, Jussi Ra¨isa¨nen2, Tam Pham2, Anna Karmi2, Antti Viljanen2, Riitta Parkkola2, Jarna Hannukainen2, Pirjo Nuutila2. 1Medical Biochemistry & Genetics & Turku PET Centre, University of Turku, Finland, 2Turku PET Centre, University of Turku, Finland Disclosures: Riku Kiviranta, None

COFFEE BREAK 4:00 pm - 4:30 pm

Hall GH

CONCURRENT ORAL SESSION 37: OSTEOBLASTS 4:30 pm - 6:00 pm

Room 20A

Moderators: Amjad Javed, Ph.D. University of Alabama at Birmingham, USA Disclosures: Amjad Javed, None

Disclosures: Koichi Matsuo, None

4:30 pm 1217

Positive Feedback Regulation of microRNA-218 Linked to Wnt Signaling Promotes Osteoblast Differentiation Mohammad Hassan*1, Yukiko Maeda1, Mohammad Jafferji1, Jonathan Gordon1, Zhaoyong Li 1, Carlo Croce2, Andre Van Wijnen1, Janet Stein1, Gary Stein1, Jane Lian1. 1 University of Massachusetts Medical School, USA, 2The Ohio State University, USA Disclosures: Mohammad Hassan, None

4:45 pm 1218

Wnt11 Is a Novel Inhibitor of Trabecular Bone Mass Mariya Sweetwyne*, Bernadette Hsu, Megan Hays, Kurt Hankenson. University of Pennsylvania, USA Disclosures: Mariya Sweetwyne, None

5:00 pm 1219

Implantation of Hedgehog-Activated Mscs Regenerates Periosteal Like Bone Formation in a Murine Bone Allograft Repair Model Chunlan Huang*1, Ming Xue1, Fanjie Zhang1, Regis O’Keefe2, Xinping Zhang1. 1 University of Rochester Medical Center, USA, 2University of Rochester, USA Disclosures: Chunlan Huang, None

289

Monday

Koichi Matsuo, M.D., Ph.D. School of Medicine, Keio University, Japan

5:15 pm 1220

Wnt Ligands from Osteoblasts are Critical for Bone Accrual Zhendong Zhong*1, Cassandra Diegel1, Bart Williams2. 1Van Andel Institute, USA, 2Van Andel Research Institute, USA Disclosures: Zhendong Zhong, None

5:30 pm 1221

ENU Chemical Mutagenesis Reveals That the Distal Region of Mouse Chromosome 11 Contains a Key Bone Size Mechanoresponsive Gene Chandrasekhar Kesavan*1, Apurva Srivastva2, David Baylink 3, Tara Azizi4, Subburaman Mohan1. 1Jerry L. Pettis Memorial VA Medical Center, USA, 2NCI (National Cancer Institute), USA, 3Loma Linda University, USA, 4Musculoskeletal Disease Center, JLP VA Medical Center, USA Disclosures: Chandrasekhar Kesavan, None

5:45 pm 1222

Smad4 Antagonizes Osteoblast Proliferation via Competitive Recruitment of ß-catenin Valerie Salazar*1, Nicholas Zarkadis2, Lisa Huang3, Jin Norris3, Gabriel Mbalaviele1, Roberto Civitelli3. 1Washington University School of Medicine, USA, 2Kansas City University of Medicine, USA, 3Washington University in St. Louis School of Medicine, USA Disclosures: Valerie Salazar, None

CONCURRENT ORAL SESSION 38: BONE, CARTILAGE AND CONNECTIVE TISSUE MATRIX & DEVELOPMENT 4:30 pm - 6:00 pm

Room 30CDE

Moderators: Gregory A. Clines, M.D., Ph.D. University of Alabama at Birmingham, USA Disclosures: Gregory Clines, None

Ling Qin, Ph.D. Chinese University of Hong Kong, Hong Kong Disclosures: Ling Qin, None

4:30 pm 1223

MMP13 is A Critical Target Gene during the Development of Osteoarthritis Jie Shen*1, Hongting Jin1, Meina Wang1, Bing Shu2, Baoli Wang2, Erik Sampson 1, Regis O’Keefe 1, Di Chen2. 1University of Rochester, USA, 2University of Rochester Medical Center, USA Disclosures: Jie Shen, None

4:45 pm 1224

Human Embryonic Stem Cell Derived Therapy for Articular Cartilage Shows Strong Efficacy Outcomes Without Immune Suppression David Pier 1, Jordi Tremoleda2, Derek Dauphin1, Val mann1, Brendon Noble*3. 1UCS, United Kingdom, 2Imperial College, United Kingdom, 3University Campus Suffolk, United Kingdom Disclosures: Brendon Noble, None

5:00 pm 1225

Accelerating Fracture Healing Correlates with Enhancing Angiogenesis and Mesenchymal Stem Cells in Matrilin-1 Knockout Mice Xin Li 1, Qian Chen*2. 1Brown University, USA, 2Brown University School of Medicine, USA Disclosures: Qian Chen, None

5:15 pm 1226

Adverse Effects of Hyperlipidemia on Bone Regeneration and Strength Flavia Pirih*1, Sotirios Tetradis2, Maria-Grazia Ascenzi1, Linda Demer3, Tara Aghaloo1, Yin Tintut1. 1University of California, Los Angeles, USA, 2UCLA, USA, 3David Geffen School of Medicine At University of California Los Angeles, USA Disclosures: Flavia Pirih, None

5:30 pm 1227

Adipocyte-specific Expression of FoxC2 Increases Bone Mass through Upregulation of Wnt10b Expression and Increase in Energy Production in Marrow Adipocytes Sima Rahman*1, Yalin Lu1, Piotr Czernik1, Clifford Rosen2, Ormond MacDougald3, Sven Enerback4, Beata Lecka-Czernik5. 1University of Toledo Health Sciences Campus, USA, 2 Maine Medical Center, USA, 3University of Michigan Medical School, USA, 4University of Gothenburg, Sweden, 5University of Toledo College of Medicine, USA Disclosures: Sima Rahman, None

290

5:45 pm 1228

A Dkk3 Reporter Identifies Progenitors of the Fibrocartilage and Periosteum of the Fracture Callus Yu Mori*, Xi Jiang, Douglas Adams, David Rowe. University of Connecticut Health Center, USA Disclosures: Yu Mori, None

CONCURRENT ORAL SESSION 39: CANCER AND BONE (BASIC, TRANSLATIONAL AND CLINICAL) 4:30 pm - 6:00 pm

Room 32AB

Moderators: Matthew T. Drake, M.D., Ph.D. Mayo Clinic College of Medicine, USA Disclosures: Matthew Drake, None

Katherine N. Weilbaecher, M.D. Washington University in St. Louis School of Medicine, USA Disclosures: Katherine Weilbaecher, None

4:30 pm 1229

Prevention of Tumor Growth and Bone Destruction in Myeloma by Pim Kinase Inhibition Masahiro Hiasa*1, Ayako Nakano2, Keiichiro Watanabe 3, Cui Qu4, Takeshi Harada4, Shirou Fujii4, Hirokazu Miki4, Shingen Nakamura4, Kumiko Kagawa4, Kyoko Takeuchi 4, Eiji Tanaka1, Kenzo Asaoka1, Shuji Ozaki4, Toshio Matsumoto 5, Masahiro Abe6. 1 University of Tokushima Graduate School, Japan, 2University of Tokushima, Graduate School of Medicine, Japan, 3The University of Tokushima Graduate School of Oral Science, Japan, 4University of Tokushima Graduate School of Medicine, Japan, 5University of Tokushima Graduate School of Medical Sciences, Japan, 6University of Tokushima, Japan Disclosures: Masahiro Hiasa, None

4:45 pm 1230

The Role of S100A4/RAGE Signaling in Prostate Cancer Bone Metastasis Jennifer Paige-Robinson*1, Leland Chung2, Omar Hameed1, John A. Petros3, Majd Zayzafoon 4. 1University of Alabama-Birmingham, USA, 2Cedars Sinai Medical center, USA, 3Emory University & Atlanta VA Medical Center, USA, 4University of Alabama at Birmingham, USA Disclosures: Jennifer Paige-Robinson, None

5:00 pm 1231

Disclosures: Barbara Silva, None

5:15 pm 1232

Inhibition of Discoidin Domain Receptor-1 (DDR1) Impairs Tumor-Induced Bone Metastatic Homing and Colonization Karmele Valencia*1, Cristina Ormaza´bal2, Carolina Zandueta2, Diego Luis-Ravelo2, Iker Anto´n 2, Susana Martı´nez-Canarias 2, Fernando Lecanda1. 1Foundation for Applied Medical Research, Spain, 2Center for Applied Medical Research (CIMA), Spain Disclosures: Karmele Valencia, None

5:30 pm 1233

The Ubiquitin E3 Ligase WWP1 Negatively Regulates Breast Cancer Bone Metastasis by Promoting Lysosomal Degradation of CXCR4 Lei Shu*1, Kristina Subik1, Qianqian Liang 1, David Hicks1, Brendan Boyce1, Linda Schiffhauer 1, Di Chen 1, Ping Tang1, Lianping Xing2. 1University of Rochester Medical Center, USA, 2University of Rochester, USA Disclosures: Lei Shu, None

291

Monday

Leukemia Progression Depends on the Presence of Osteoblasts Barbara Silva*1, Maria Krevvata2, J. Sanil Manavalan2, Chiyuan Zhang3, Linda Johnson 4, Renier Brentjens 5, Aris Economides6, Ellin Berman5, Stavroula Kousteni1. 1Columbia University Medical Center, USA, 2Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, USA, 3Columbia University, USA, 4Comparative Pathology & Laboratory Medicine, Cornell University & Memorial Sloan-Kettering Cancer Center, USA, 5Memorial Sloan-Kettering Cancer Center, USA, 6 Regeneron Pharmaceuticals, Inc., USA

5:45 pm 1234

Dual Function of the Estrogen Receptor Related Receptor Alpha (ERRa) In Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin Anais Fradet1, He´le`ne Sorel 1, Lamia Bouazza1, Delphine Goehrig1, Baptiste De´palle1, Akeila Bellahcene2, Vincent Castronovo2, He´le`ne Follet1, Francoise Descotes3, Jane Aubin4, Philippe A.R. Clezardin5, Edith Bonnelye*6. 1Inserm, UMR1033, France, 2GIGACancer, University of Lie`ge, Belgium, 3Service de Biochimie Biologie Mole´culaire Sud, Centre hospitalier Lyon Sud, France, 4University of Toronto Faculty of Medicine, Canada, 5 INSERM & University of Lyon, Fra, 6Faculte de Medecine RTH Laennec, France Disclosures: Edith Bonnelye, None

CONCURRENT ORAL SESSION 40: SKELETAL LOADING AND BONE QUALITY 4:30 pm - 6:00 pm

Room 31ABC

Moderators: Jean D. Sibonga, Ph.D. NASA Johnson Space Center, USA Disclosures: Jean Sibonga, None

Lilian I. Plotkin, Ph.D. Indiana University School of Medicine, USA Disclosures: Lilian Plotkin, None

4:30 pm 1235

Variable Bone Formation Response to Skeletal Axial Load in Mice With a Conditional Deletion of the Connexin43 (Cx43) Gene (Gja1) Susan Grimston*1, Marcus Watkins2, Michael Brodt3, Matthew Silva2, Roberto Civitelli2. 1 Washington University School of Medicine, USA, 2Washington University in St. Louis School of Medicine, USA, 3Washington University in St. Louis, USA Disclosures: Susan Grimston, None

4:45 pm 1236

Periostin Deficiency Increases Cortical Microcracks and Reduces Woven Bone Formation in Mice Subjected to Fatigue Loading Nicolas Bonnet*1, Markus burkhart 2, Andres Laib3, Serge Ferrari4. 1Division of Bone Diseases, Geneva University Hospital & Faculty of Medicine, S, Switzerland, 2SCANCO Medical AG, Switzerland, 3Scanco Medical, Switzerland, 4Geneva University Hospital & Faculty of Medicine, Switzerland Disclosures: Nicolas Bonnet, None

5:00 pm 1237

Osteocyte Level Strain Determination Using A Multiscale Mouse Forearm Model Ganesh Thiagarajan 1, Yunkai Lu2, Mark Dallas3, Mark Johnson*4. 1University of Missouri - Kansas City, USA, 2UMKC School of Computing & Engineering, USA, 3 UMKC School of Dentistry, USA, 4University of Missouri, Kansas City Dental School, USA Disclosures: Mark Johnson, None

5:15 pm 1238

Previous Exposure to Microgravity Does not Adversely Affect Second Exposure in the Tibia of Hindlimb Unloaded Adult Male Rats Yasaman Shirazi-Fard*1, Derrick Morgan1, Joshua Kupke1, Joshua Davis1, Florence Lima2, Elizabeth Greene1, Alyssa McCue1, Joseph Marchetti 1, Joey Thompson 1, Susan Bloomfield 1, Harry Hogan1. 1Texas A&M University, USA, 2University of Maryland School of Medicine, USA Disclosures: Yasaman Shirazi-Fard, None

5:30 pm 1239

Increased Sensitivity to Skeletal Unloading in Connexin43-deficient Mice Shane Lloyd*, Emmanuel Paul, Yue Zhang, Henry Donahue. The Pennsylvania State University College of Medicine, USA Disclosures: Shane Lloyd, None

5:45 pm 1240

Mechanical Regulation of GSK3b in MSC is Dependent on Akt Activation via Rictor/ mTORC2 Natasha Case*1, Jacob Thomas2, Buer Sen 3, Zhihui Xie2, Maya Styner1, Janet Rubin1. 1 University of North Carolina, Chapel Hill, School of Medicine, USA, 2UNC, USA, 3 University of North Carolina At Chapel Hill, USA Disclosures: Natasha Case, None

292

CONCURRENT ORAL SESSION 41: RISK OF TYPICAL AND ATYPICAL FRACTURES 4:30 pm - 6:00 pm

Room 29ABCD

Moderators: Douglas C. Bauer, M.D. University of California, San Francisco, USA Disclosures: Douglas Bauer, None

Elizabeth Shane, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Elizabeth Shane, None

4:30 pm 1241

A Prospective Study of Predictors of Radiographic Spine Fracture in Men: the MROS study Dennis Black*1, Katherine Wilt Peters2, Kristine Ensrud3, Jane Cauley4, Eric Orwoll5, Steven Cummings6, John Schousboe7. 1University of California, San Francisco, USA, 2 California Pacific Medical Center, USA, 3Minneapolis VA Medical Center / University of Minnesota, USA, 4University of Pittsburgh Graduate School of Public Health, USA, 5 Oregon Health & Science University, USA, 6San Francisco Coordinating Center, USA, 7 Park Nicollet Clinic, University of Minnesota, USA Disclosures: Dennis Black, None

4:45 pm 1242

Bone Loss Accelerates After Age 75: A Prospective, Longitudinal Study Steven Cummings* 1, Lily Lui 1, Jane Cauley2, Kristine Ensrud3, Teresa Hillier4, Marc Hochberg5. 1San Francisco Coordinating Center, USA, 2University of Pittsburgh Graduate School of Public Health, USA, 3Minneapolis VA Medical Center / University of Minnesota, USA, 4Kaiser Center for Health Research, USA, 5University of Maryland School of Medicine, USA Disclosures: Steven Cummings, None

5:00 pm 1243

Prediction of Fracture Risk in Men: A Cohort Study Liisa Byberg*1, Rolf Gedeborg2, Thomas Cars2, Johan Sundstro¨m 2, Lars Berglund3, Lena Kilander2, Hakan Melhus4, Karl Michaelsson 3. 1Uppsala Universitet, Sweden, 2Uppsala University, Sweden, 3Uppsala Clinical Research Center, Sweden, 4Uppsala University Hospital, Sweden Disclosures: Liisa Byberg, None

5:15 pm 1244

Fracture Prediction from Repeat BMD Measurements in Routine Clinical Practice for: The Manitoba BMD Cohort William Leslie*1, Suzanne Morin2, Lisa Lix3. 1University of Manitoba, Canada, 2McGill University Health Centre, Canada, 3University of Saskatchewan, Canada Disclosures: William Leslie, None

Subtrochanteric/femoral Shaft versus Hip Fractures: Incidence and Identification of Risk Factors Milka Maravic*1, Agnes Ostertag2, Martine Cohen-Solal 3. 1De´partement d’Information Me´dicale, Hoˆpital Le´opold Bellan, France, 2U606 INSERM, France, 3Centre Viggo Petersen, France Disclosures: Milka Maravic, None

5:45 pm 1246

Recent Trends in Hip Fracture Rates by Race/Ethnicity in Older US Adults Nicole Wright*1, Wilson Smith1, Kenneth Saag1, Jeffrey Curtis 1, Michael Morrisey1, Meredith Kilgore2, Huifeng Yun1, Jie Zhang1, Elizabeth Delzell 1. 1University of Alabama at Birmingham, USA, 2University of Alabama At Birmingham School of Public Health, USA Disclosures: Nicole Wright, Amgen, 2

293

Monday

5:30 pm 1245

CONCURRENT ORAL SESSION 42: NEW ASPECTS OF STANDARD OSTEOPOROSIS TREATMENT 4:30 pm - 6:00 pm

Room 20BCD

Moderators: Adi Cohen, M.D., MHS Columbia University Medical Center, USA Disclosures: Adi Cohen, None

Emily Margaret Stein, M.D. Columbia University College of Physicians and Surgeons, USA Disclosures: Emily Stein, None

4:30 pm 1247

Fractures and Mortality in Relation to Different Osteoporosis Treatments Huifeng Yun* 1, Elizabeth Delzell1, Robert Matthews1, Meredith Kilgore2, Kenneth Saag1, Cathleen Colon-Emeric 3, Christopher O’Connor4, Kenneth Lyles3, Michael Morrisey1, Jeffrey Curtis1. 1University of Alabama at Birmingham, USA, 2University of Alabama At Birmingham School of Public Health, USA, 3Duke University Medical Center, USA, 4 Duke University, USA Disclosures: Huifeng Yun, Amgen, 2

4:45 pm 1248

Who Is at Highest Risk for New Vertebral Fractures After 3 Years of Annual Zoledronic Acid and Who Should Remain on Treatment? Felicia Cosman*1, Jane Cauley2, Richard Eastell3, Steven Boonen4, Lisa Palermo5, Ian Reid6, Steven Cummings7, Dennis Black5. 1Helen Hayes Hospital, USA, 2University of Pittsburgh Graduate School of Public Health, USA, 3University of Sheffield, United Kingdom, 4Center for Metabolic Bone Disease & Division of Geriatric Medicine, Belgium, 5 University of California, San Francisco, USA, 6University of Auckland, New Zealand, 7 San Francisco Coordinating Center, USA Disclosures: Felicia Cosman, Merck Eli Lilly, Amgen, Novartis,5; Eli Lilly, Amgen, Novartis, 8; Eli Lilly, Novartis, Amgen, 2

5:00 pm 1249

Increase of Serum PINP Is Associated with Trabecular Microstructural Improvement in Patients on Teriparatide Pretreated with Alendronate Astrid Fahrleitner-Pammer*1, Harald Dobnig2, Jan Stepan3, Helmut Petto4, Imre Pavo5. 1 Medical University Graz, Austria, 2Department of Internal Medicine, Division of Endocrinology & Metabolism, Medical University of Graz, Austria, 3Charles University, Czech Republic, 4Lilly Research Center, Austria, 5Eli Lilly & Company, Austria Disclosures: Astrid Fahrleitner-Pammer, None

5:15 pm 1250

Parathyroid Hormone (1-84) and Ibandronate Administered Concurrently Vs. Sequentially: The PTH and Ibandronate Combination Study (PICS) Randomized Trial Anne Schafer*1, Lisa Palermo2, Dolores Shoback3, Deborah Sellmeyer4, Dennis Black2. 1 University of California, San Francisco & the San Francisco VA Medical Center, USA, 2 University of California, San Francisco, USA, 3VA Medical Center, USA, 4The Johns Hopkins Bayview Medical Center, USA Disclosures: Anne Schafer, None

5:30 pm 1251

Use of oral Bisphosphonates and the Risk of Subtrochanteric and Diaphyseal Fractures in Older Men and Women Suzanne Morin*1, Behlouli Hassan2, William Leslie3, Jacques Brown4, David Goltzman1, Louise Pilote5. 1McGill University Health Centre, Canada, 2McGill University Research Institute, Canada, 3University of Manitoba, Canada, 4Laval University, Canada, 5McGill University, Canada Disclosures: Suzanne Morin, Amgen, Novartis, 8; Amgen, Novartis, Eli Lilly, Warner-Chilcott, 5; Amgen, 2

5:45 pm 1252

The Effect of Glucocorticoid Therapy on Regulators of Bone Formation in Postmenopausal Women Treated with Teriparatide or Alendronate Fatma Gossiel*1, Nancy Lane2, Richard Eastell3. 1The University of Sheffield, United Kingdom, 2 University of California, Davis Medical Center, USA, 3University of Sheffield, United Kingdom Disclosures: Fatma Gossiel, None

294

MOLECULAR BIOLOGY AND PATHOLOGY OF BONE WORKING GROUP Sixteenth Annual Meeting Supported by educational grants from Abbott Laboratories and the Tissue Repair Research Unit, Pfizer Inc. Ticket Required 6:15 pm - 8:45 pm

Room 31ABC

Light Fare

6:15 pm

Moderator David Rowe, M.D. Director, Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, USA

6:30 pm

Applications of Human Pluripotent Stem Cells Louise Laurent, M.D., Ph.D. Dept. of Reproductive Medicine, University of California San Diego and Center for Regenerative Medicine. The Scripps Research Institute. Dr. Laurent is renowned for her work characterizing regulatory networks, including MicroRNAs, that define human pluripotent stem cells.

7:10 pm

Bone Marrow Stromal Cells and Clinical Applications Pamela G. Robey, Ph.D. Craniofacial and Skeletal Diseases Branch, Chief, Skeletal Biology Section, CSDB, CoCoordinator, NIH Bone Marrow Stromal Cell Transplantation Center, National Institutes of Health/NIDCR

7:35 pm

Control of Pluripotent Stem Cell Proliferation Gary S. Stein, Ph.D. Co-Director, UMass Memorial Cancer Center of Excellence, The Gerald L. Haidak, M.D. and Zelda S. Haidak Distinguished Professor and Chair of Cell Biology, Department of Cell Biology, University of Massachusetts Medical School, USA

8:00 pm

Approaches for Stem Cell Fate Mapping Ivo Kalajzic, M.D., Ph.D. Assistant Professor, Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, USA

8:25 pm

Short Presentations Organizers: Gary S. Stein, Ph.D. and Jane B. Lian, Ph.D. Advisory Committee: Sylvia Christakos, PhD; Barbara Kream, PhD; Nicola C. Partridge, PhD; J. Wesley Pike, PhD; Thomas Spelsberg, PhD; John M. Wozney, PhD; Marian F. Young, PhD Disclosures: Dr. David Rowe - Nothing to Disclose; Dr. Louise Laurent - Nothing to Disclose; Dr. Pamela Robey - Nothing to Disclose; Dr. Gary Stein - Nothing to Disclose; Dr. Ivo Kalajzic - Nothing to Disclose.

295

Monday

6:10 pm

WORKING GROUP ON MUSCULOSKELETAL REHABILITATION IN PATIENTS WITH OSTEOPOROSIS Ticket Required 6:30 pm - 8:40 pm

Room 30AB

Chairs: Mersheed Sinaki, Mayo Clinic and Mayo Clinic College of Medicine and Michael Pfeifer, Institute of Clinical Osteology, Bad Pyrmont 6:30 p.m. Welcome and Introduction Mehrsheed Sinaki, M.D., M.S. Mayo Clinic and Mayo Clinic College of Medicine Rochester, MN, U.S.A. Part I:

Invited Presentations (Presentation 15 minutes + Q & A - 5 minutes)

6:35 p.m. Frailty and the medical management of hip fractures Steven Boonen, Ph.D., M.D. Professor of Clinical Gerontology and Geriatric Medicine Center for Musculoskeletal Research Leuven University Department of Experimental Medicine Leuven, 3000, Belgium 6:55 p.m. The multiple consequences of hip fractures : Implications for post fracture management to optimize outcomes. Jay Magaziner, Ph.D., M.D. Prof. and Chair Dept. of Epidemiology and Public Health University of Maryland Baltimore, Maryland 21201, U.S.A. 7:15 p.m. Future clinical trials on hip fractures: New recommendations from the International Hip Protector Research Group Michael Pfeifer, M.D. Head of Clinical Research Institute of Clinical Osteology Bad Pyrmont, 31812, Germany Part II:

Selected Presentations from the ASBMR official program: (Presentation 10 minutes, Q & A -5 minutes

7:35 p.m. Prevention of hip fractures with a multifactorial educational program in elderly Finnish women: a population-based, long-term controlled clinical trial. Tuula Pekkarinen, M.D. Dept of Internal Medicine Peijas Hospital, Helsinki University Central Hospital Helsinki, Vantaa 014000, Finland 7:50 p.m. Hip extensor lean cross-sectional area is associated with incident hip fracture: the age/gene/ environment susceptibility study-Reykjavik. Thomas F. Land, Ph.D. Professor in Residence Dept. of Radiology, University of California, San Francisco San Francisco, CA 94143-946, U.S.A. 8:05 p.m. The relationship between serum vitamin D levels and bone histomorphometry in elderly patients with hip fractures. Abbas A Ismail, M.D.

296

Dept. of Rheumatology, Stockport NHS Trust Manchester University United Kingdom 8:20 p.m. Trends in hip fracture rates in Canada: an age-period-cohort analysis. Sonia Jean Insitut National de Sante´ Publique du Que´bec Que´bec City Que´bec, Canada 8:35 p.m. Summary and Closure Michael Pfeifer, M.D. Head of Clinical Research Institute of Clinical Osteology Gustav Pommer Bad Pyrmont 31812, GERMANY 8:40 p.m. Adjourn

WORKING GROUP ON OSTEOPOROSIS IN RHEUMATIC DISEASES Ticket Required 6:30 pm - 8:30 pm

Room 30CDE

6:30 p.m. Opening W.F. Lems, Amsterdam 6:35 p.m. New Findings in Chondrocyte Biology Mary Goldring, Ph.D., New York, USA 7:00 p.m. Immune Mediate Inflammation in OA Carla R. Scanzello, M.D., Ph.D., Chicago, USA 7:25 p.m. Genetics of Osteoarhritis and Osteoporosis - Are there Overlaps? Prof Dr Andre Uitterlinden, Rotterdam, the Netherlands 7:50 p.m. Usefulness of Cartilage and Bone Turnover Markers in OA Prof Morten Karsdal, Southern Danish University, Head of R&D, Nordic Bioscience, Denmark

Disruption of Mitogen Inducible Gene 6 (MIG6) in the Mouse Genome Accelerates Surgical Induced Osteoarthritis and Down Regulates Wnt Signaling Danese Joiner, Van Andel Research Institute, USA

297

Monday

8:15 p.m. Abstract presentations in the field on inflammation and osteoarthritis: R-spondin 2 is a New Key Player in Human Osteoarthritis Osteoblasts to Orchestrate their Abnormal Canonical Wnt Signaling Elie Abed, CHUM, Hoˆpital Notre-Dame, Canada

Tuesday, September 20, 2011

TUESDAY, SEPTEMBER 20, 2011 DAY-AT-A-GLANCE Time/Event/Location

All locations in the San Diego Convention Center unless otherwise noted

8:30 am - 10:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Concurrent Oral Session 43: Osteoblasts Room 29ABCD 8:30 am - 10:00 am . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Concurrent Oral Session 44: Osteoporosis Fractures and Clinical Outcomes Room 20CD 10:00 am - 10:15 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 Coffee Break Room 20CD Lobby 10:15 am - 11:45 am. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301 Plenary Symposium III – Novel Genetic and Epigenetic Approaches to Human Disease Room 20CD

298

CONCURRENT ORAL SESSION 43: OSTEOBLASTS 8:30 am - 10:00 am

Room 29ABCD

Moderators: Edward C. Hsiao, M.D., Ph.D. University of California, San Francisco, USA Disclosures: Edward Hsiao, None

David M. Findlay, Ph.D. University of Adelaide, Australia Disclosures: David Findlay, None

8:30 am 1253

Nuclear Factor of Activated T-Cells (NFAT)c2 Inhibits Notch Canonical Signaling Stefano Zanotti*, Anna Smerdel-Ramoya, Ernesto Canalis. St. Francis Hospital & Medical Center, USA Disclosures: Stefano Zanotti, None

8:45 am 1254

NF-kB RelB Negatively Regulates Osteoblast Function and Bone Formation Zhenqiang Yao*1, Yanyun Li 2, Lianping Xing1, Brendan Boyce2. 1University of Rochester, USA, 2University of Rochester Medical Center, USA Disclosures: Zhenqiang Yao, None

9:00 am 1255

Alteration of the Wnt/b-Catenin Pathway by Runx2 Overexpression In Vivo Coline Haxaire*, Eric Hay, Valerie Geoffroy. INSERM Unit 606, France Disclosures: Coline Haxaire, None

9:15 am 1256

2011 ASBMR YOUNG INVESTIGATOR AWARD Smad4 Coordinates BMP Signaling through p38 in Osteoblasts and is Required for Bone Anabolic Response to Canonical Wnt Signaling Valerie Salazar*1, Lisa Huang2, Jin Norris2, Sheri Bonar2, Gabriel Mbalaviele 1, Roberto Civitelli 2. 1Washington University School of Medicine, USA, 2Washington University in St. Louis School of Medicine, USA Disclosures: Valerie Salazar, None

9:30 am 1257

Blockade of EphrinB2/EphB4 Interactions Disrupts Osteoblast and Osteoclast Differentiation In Vivo Farzin Takyar*1, Stephen Tonna1, Patricia Ho1, Blessin Crimeen-Irwin 1, Holly Brennan1, Valery Krasnoperov 2, T. John Martin1, Natalie Sims1. 1St. Vincent’s Institute of Medical Research, Australia, 2Vasgene Therapeutics Inc., USA Disclosures: Farzin Takyar, None

9:45 am 1258

Nck, Actin Cytoskeleton Protein, Supports Osteoblastic Bone Increment and Suppresses Osteoclastic Bone Loss Smriti Aryal A.C*1, Kentaro Miyai2, Yoichi Ezura3, Tadayoshi Hayata4, Takuya Notomi5, Tetsuya Nakamoto 2, Tony pawson6, Masaki Noda2. 1Department of molecular pharmacology, Tokyo medical & dental university, Japan, 2Tokyo Medical & Dental University, Japan, 3Tokyo Medical & Dental University, Medical Research Insititute, Japan, 4Medical Reserach Institute, Tokyo Medical & Dental University, Japan, 5GCOE, Tokyo Medical & Dental University, Japan, 6Mount Sinai hospital, Canada Disclosures: Smriti Aryal A.C, None

8:30 am - 10:00 am

Room 20CD

Moderators: Dennis Black, Ph.D. UCSF Disclosures: Dennis Black, None

Jane A. Cauley, Ph.D. University of Pittsburgh Graduate School of Public Health, USA Disclosures: Jane Cauley, None

299

Tuesday

CONCURRENT ORAL SESSION 44: OSTEOPOROSIS FRACTURES AND CLINICAL OUTCOMES

8:30 am 1259

High Cumulative Incidences of Poor Outcomes Following Osteoporotic Fractures in Elderly Women and Men: A Competing Risk Analysis Dana Bliuc*, Nguyen Nguyen, Tuan Nguyen, John Eisman, Jacqueline Center. Garvan Institute of Medical Research, Australia Disclosures: Dana Bliuc, None

8:45 am 1260

2011 ASBMR YOUNG INVESTIGATOR AWARD Direct Medical Resources Utilization Associated with Osteoporosis-Related Fractures in Postmenopausal Women Sonia Jean*1, Louis Bessette2, Etienne Belzile3, Suzanne Morin4, K. Shawn Davison3, Louis-Georges Ste-Marie5, Bernard Candas3, Sylvie Dodin3, Jacques Brown3. 1INSTITUT ´ PUBLIQUE DU QUE ´ BEC, Canada, 2Centre Hospitalier De NATIONAL DE SANTE L’Universite Laval, Canada, 3Laval University, Canada, 4McGill University Health Centre, Canada, 5Hospital Saint-Luc, CHUM, Canada Disclosures: Sonia Jean, None

9:00 am 1261

Duration of Excess Mortality After Hip Fractures in Oslo, Norway: A Long Term Follow Up Trine Elisabeth Finnes*1, Haakon E. Meyer2, Tore Wentzell-Larsen3, Cathrine Marie Lofthus4. 1Department of Internal Medicine, Innlandet Hospital Trust, Hamar, Norway, Norway, 2Department of Community Medicine, Faculty of Medicine, University of Oslo, Norway & Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway, Norway, 3Biostatistics & Epidemiology Unit, Oslo University Hospital, Norway, 4 Department of Clinical Endocrinology, Oslo University Hospital, Aker, Norway, Norway Disclosures: Trine Elisabeth Finnes, None

9:15 am 1262

Mortality and Fracture Rate before and after Introduction of a Fracture Liaison Service Sandrine Bours*1, Tineke Van Geel 2, Piet Geusens3, Kirsten Huntjens2, Geert-Jan Dinant4, Joop Van Den Bergh5. 1Maastricht University Medical Centre, The Netherlands, 2 Maastricht University, The Netherlands, 3University Hasselt, Belgium, 4Maastricht University, Netherlands, 5Maastricht UMC & VieCuri MC Noord-Limburg, USA Disclosures: Sandrine Bours, None

9:30 am 1263

Falling Rates of Fractures in the United States from 1992-1997 to 2002-2007 Steven Cummings* 1, Li-Yung Lui2, Jane Cauley3, Teresa Hillier4, Marc Hochberg5. 1San Francisco Coordinating Center, USA, 2California Pacific Medical Center Research Institute, USA, 3University of Pittsburgh Graduate School of Public Health, USA, 4Kaiser Center for Health Research, USA, 5University of Maryland School of Medicine, USA Disclosures: Steven Cummings, None

9:45 am 1264

Secular Trends in Incidence of Osteoporosis-related Fractures Differ Depending on Fracture Type Bjorn Rosengren*1, Ingemar Peterson2, Magnus Karlsson1, Martin Englund2. 1Ska˚ne University Hospital Malmo¨, Lund University, Sweden, 2Musculoskeletal Sciences, Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, Sweden Disclosures: Bjorn Rosengren, None

COFFEE BREAK 10:00 am - 10:15 am

300

Room 20CD Lobby

PLENARY SYMPOSIUM III – NOVEL GENETIC AND EPIGENETIC APPROACHES TO HUMAN DISEASE 10:15 am - 11:45 am

Room 20CD

Co-Chairs Jennifer J. Westendorf, Ph.D. Mayo Clinic, USA Disclosures: Jennifer Westendorf, Amgen 1

Andre J. Van Wijnen, Ph.D. University of Massachusetts Medical School, USA Disclosures: Andre Van Wijnen, None

10:15 am MicroRNAs in Skeletal Development and Postnatal Bone Turnover Jane B. Lian, Ph.D. University of Massachusetts Medical School, USA Disclosures: Jane Lian, None

10:45 am Overview of Epigenetics and Disease James Herman, Ph.D. Johns Hopkins University, USA Disclosures: James Herman, None

11:15 am Systems Genetics: A Novel Approach for the Dissection of Complex Diseases Charles R. Farber, Ph.D. University of Virginia, USA Disclosures: Charles Farber, None

Tuesday 301

EXHIBITS We encourage you to visit the Exhibit Hall to learn about the newest bone and mineral related products and services, talk to experts about advancements in the bone and mineral field and thank our supporters for their participation. The company descriptions below were provided by each exhibiting company and do not represent an endorsement by ASBMR of any company, product or service. Exhibit Hall Hours Friday, September 16, 2011 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5:45 p.m. – 7:00 p.m. Saturday, September 17, 2011 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 a.m. – 4:00 p.m. Sunday, September 18, 2011 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 a.m. – 4:00 p.m. Monday, September 19, 2011. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:30 a.m. – 4:30 p.m. Active Life Scientific, Inc. Santa Barbara, California, USA Booth # 422 Active Life Scientific, Inc. develops and markets BioDentTM, the world’s first Reference Point Indenter (RPI). RPI enables life scientists to easily include tissue level strength, quality, and mechanical property data in their research. The in situ and in vivo testing modes enable first of its kind translational research. ALPCO Diagnostics Salem, New Hampshire, USA Booth # 128 ALPCO is committed to offering high quality immunoassays for bone metabolism research. Specifically, ALPCO offers the first commercially available ELISA for sclerostin as well as ELISAs for Cortisol, DKK-1, vitamin D metabolites, and forty other analytes. To learn more about ALPCO products, visit www.alpco.com. American Orthopaedic Association Rosemont, Illinois, USA Booth # 423 Own the BoneH, a web-based quality improvement program, was developed by the AOA to encourage the co-management and improved identification, evaluation, and treatment of patients with osteoporosis after fragility fractures. The national patient registry provides hospitals with access to benchmarking capabilities to document improvements in patient care over time as well as compare results to other institutions nationwide. Amgen Thousand Oaks, California, USA Booth # 111 Amgen (NASDAQ:AMGN), a biotechnology pioneer, discovers, develops, and delivers innovative human therapeutics. Our medicines help millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis, bone disease, and other serious illnesses. With a deep and broad pipeline of potential new medicines, we continue to advance science to serve patients. Bayer HealthCare, Consumer Care Morristown, New Jersey, USA Booth # 305 Bayer HealthCare LLC’s Consumer Care Division is a global marketer of over-the-counter medications and nutritional supplements with a portfolio of some of the most trusted and recognizable brands in the world. Citracal will be featured at booth #305. b-cube AG Schlieren, Zurich, Switzerland Booth # 303 b-cube is an innovative service provider for high quality microCT imaging and 3D data analysis. We support our clients to efficiently quantify and visualize their research and development projects through standardized or customized analysis concepts.

302

Biomedica Vienna, Austria Booth # 335 Biomedica is specialized in the research, development and production of innovative immunoassays (ELISAs) for clinical research in the field of bone metabolism. Their ELISAs cover the regulatory markers such as Sclerostin, DKK-1, OPG, free sRANKL, and Cathepsin K. Detailed product information can be found on www.bmgrp.com. BIOQUANT Image Analysis Corporation Nashville, Tennessee, USA Booth # 318 BIOQUANT provides the world’s most advanced integrated hardware, software, and service solutions for bone biology research. BIOQUANT SCAN provides fully automated brightfield, fluorescence, and polarized light bone tissue and cell culture scanning at sub-micron resolutions. BIOQUANT OSTEO provides high-throughput analysis of histology and cell cultures. BIOQUANT RESEARCH SERVICES provide contract histotechnology and histomorphometry services in non-decalcified tissues for academic support and pre-clinical research.

Charles River Wilmington, Massachusetts, USA Booth # 319 Charles River specializes in preclinical bone research using In vivo models to evaluate the safety and efficacy of drug candidates for osteoporosis, arthritis, and orthopedics. Integrated services include densitometry, histomorphometry, biomechanics, micro-CT, and biomarker evaluations. Corning Incorporated Lowell, Massachusetts, USA Booth # 112 Corning Life Sciences, a global leader in the laboratory products market, offers core capabilities in materials, surfaces and biophotonics. Innovative products include new surfaces such as the Corning Synthemax, Surface for stem cell culture, Ultra Low Attachment Surface, Corning CellBIND, Surface for low-serum requirements, and the Osteo Assay Surface for osteogenesis assays. Covance Princeton, New Jersey, USA Booth # 200 Covance Discovery and Translational Services is the drug discovery and translational services resource that more effectively and efficiently bridges research gaps between preclinical and clinical phases. Only Covance drives innovative pipeline development by integrating early nonclinical safety, efficacy and discovery services with expert capabilities in biomarkers, genomics, immunology and antibodies. DiaSorin, Inc. Stillwater, Minnesota, USA Booth # 401 DiaSorin has set the standard in Vitamin D testing for more than 25 years, and has distributed more than 120 million Vitamin D tests. The LIAISONH 25 OH Vitamin D TOTAL Assay is a fully automated chemiluminescent assay measuring both D2 and D3, for a TOTAL 25 OH Vitamin D result with superior low end functional sensitivity. EMD Millipore* Billerica, Massachusetts, USA Booth # 410 EMD Millipore offers the largest portfolio of biomarker immunoassays including RIAs, ELISAs Multiplex Assays (MILLIPLEXHMAP) using the LuminexH xMAPH technology for the better understanding of the mechanisms of diseases such as bone metabolism, diabetes, obesity, cancer, cardiovascular disease, inflammation and more, providing consistent, high-quality products for research and drug development. *ASBMR thanks EMD Millipore for their support of the ASBMR Exhibitors Circle.

303

Exhibits

Caliper Life Sciences Hopkinton, Massachusetts, USA Booth # 320 Caliper Life Sciences provides innovative tools and services for life science research and drug discovery. Caliper’s Imaging platforms provide longitudinal molecular and anatomical insights into the mechanisms of disease progression. The new IVIS SpectrumCT and the QuantumFX uCT have set new standards in quantitative, low dose longitudinal in vivo modeling.

Enobia Pharma Montreal, Quebec, Canada Booth # 418 Enobia Pharma Inc. is a private Montreal-based company focused on the development of therapeutics to treat serious bone disorders for which there are no drug therapies currently approved. ENB-0040, an investigational drug for the treatment of hypophosphatasia, is the Company’s lead program. For more information, please visit www.enobia.com. FASEB MARC Bethesda, Maryland, USA Booth # 432 FASEB MARC Program provides a variety of activities to support the training of minority students, postdoctorates, faculty and scientists in the biomedical and behavioral sciences. We offer travel awards for scientific meetings, research conferences, and student summer research opportunities programs. We also sponsor Career Development Programs including grantsmanship training seminars. Faxitron X-Ray, LLC Lincolnshire, Illinois, USA Booth # 206 Faxitron X-Ray is the global standard in dedicated digital radiography for breast biopsy, lumpectomy, and pathology specimens with systems in use in hospitals and breast centers around the world. Over the past 30 years we have developed an installed base of over 6,000 units in healthcare facilities and research labs here and abroad. Hologic Bedford, Massachusetts, USA Booth # 411 Hologic, a leading provider of women’s health products, showcases the DiscoveryTM series of bone densitometers. Discovery offers superb imaging for rapid assessment of bone density, vertebral fractures, aortic calcification visualization and detailed body composition. With the most comprehensive platform, Discovery provides a complete bone, cardiovascular and obesity assessment. Immundiagnostik AG Bensheim, Hessen, Germany Booth # 324 Leading 25 and 1,25Vitamin D diagnostics in ELISA and HPLC. Innovative marker Myostatin as regulator of muscle growth. Bone metastasis risk-indicator and research tool Bone Sialoprotein. Extensive panel of bone metabolism markers and antibodies. Immunodiagnostic Systems Scottsdale, Arizona, USA Booth # 334 IDS offers specialty immunoassays for calcium metabolism, bone turnover, cartilage markers and growth disorders in manual kits and aboard the IDS-iSYS Automated System. Products of interest for clinical researchers and clinical practitioners include vitamin D, PTH, CTX-I, PINP, and IGF-I. Speak with an IDS representative for details about the full range of IDS manual and automated products. Please visit booth 334. Immutopics International San Clemente, California, USA Booth # 328 ELISA test kits for FGF-23, several forms of PTH, Osteocalcin, Calcitonin and related peptides are developed and manufactured by Immutopics. The company specializes in innovative assays for assessing calcium and phosphate regulation. Since 1989, it has been a leading source of immunoassay kits for pre-clinical studies of bone and mineral disorders in human, rat, mouse and other mammalian models. International Bone and Mineral Society (IBMS) Chicago, Illinois, USA Booth # 402 IBMS is the international organization that facilitates the generation and dissemination of knowledge of bone and mineral metabolism through communication, community, training, and multi-disciplinary meetings throughout the world.

304

International Society for Clinical Densitometry Middletown, Connecticut, USA Booth # 204 The International Society for Clinical Densitometry (ISCD) is an international non-profit society linking multiple disciplines with and interest in bone mass measurement and assessment of skeletal integrity. Jarrow Formulas, Inc. Los Angeles, California, USA Booth # 304 Jarrow Formulas is a leading supplier of nutritional supplements that creates efficacious, cutting-edge formulations based on the latest clinical research. Some Jarrow products that promote bone and joint health are Bone-Up, JarroSil, Joint Builder, and SAMe. With its state-of-the-art manufacturing facility, Jarrow updates formulas frequently to reflect current nutritional research.

Lilly USA, LLC Indianapolis, Indiana, USA Booth # 429 Lilly, a leading innovation-driven corporation, is developing a growing portfolio of pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, IN., Lilly provides answers through medicines and information for some of the world’s most urgent medical needs. Lone Oak Medical Technologies Doylestown, Pennsylvania, USA Booth # 400 The American Bone Health Society states 70% of post-menopausal women in the US are not tested for low bone mass. Lone Oak Medical Technologies has introduced the Accudexa 2 BMD screening device to alleviate this crisis. Stop by booth 400, see the lightweight, easy to operate and quick results it produces. Maccine Pte Ltd. Singapore Booth # 405 Maccine is an established preclinical CRO providing discovery support and safety assessment services. Operating on collaborative partnering models, Maccine has developed a portfolio of in vivo assays in therapeutic areas including Neurology, Metabolic Disorders and Imaging. Naturalistic models, clinical biomarkers and clinical technology platforms are utilized, supported by high-end technology and access to a world class scientific community. The facility is AAALAC-accredited and GLP compliant. Mindways Software Austin, Texas, USA Booth # 201 Mindways produces QCT bone densitometry products for spine and hip bone density measurements, bone geometry and biomechanical assessment, and tissue composition. NIH Osteoporosis and Related Bone Diseases NRC Bethesda, Maryland, USA Booth # 421 The NIH Osteoporosis and Related Bone Diseases , National Resource Center provides patients, health professionals, and the public with an important link to resources and information on metabolic bone diseases. Optasia Medical Inc. Sudbury, Massachusetts, USA Booth # 203 SpineAnalyzer facilitates analysis of vertebral deformities in lateral spine x-rays and VFA scans to help qualified healthcare professionals with their assessment. It provides an advanced, quantitative capture of vertebral shape and spinal geometry, allowing the reader to apply assessments quickly and efficiently and provides comprehensive report.

305

Exhibits

Kubtec Milford, Connecticut, USA Booth # 404 Kubtec offers the XPERT series of self-contained, shielded digital cabinet x-ray systems with detector sizes from 20 6 20 to 170 6 170. All models are portable and include high resolution imaging software with touch-screen monitors and optional BMD software. Systems can be safely operated with minimal x-ray training.

Orthometrix, Inc. Naples, Florida, USA Booth # 430 Based on pQCT technology, our XCT scanners are bone diagnostic and monitoring devices developed to make three-dimensional assessments of cortical and trabecular bone in one single evaluation. XCT’s are precise, true volumetric measurement devices that establish all bone mechanical parameters at various sites. OsteoMetrics, Inc. Decatur, Georgia, USA Booth # 300 Bone histomorphometry systems since 1989. Check out our new area of interest and thresholding tools! Paget Foundation/Bone and Cancer Foundation New York, New York, USA Booth # 403 The Paget Foundation/Bone and Cancer Foundation provides information for patients and healthcare professionals on Paget’s disease of bone and other benign diseases and cancer and bone. Perceptive Informatics Waltham, Massachusetts, USA Booth # 419 Perceptive Informatics provides comprehensive imaging services including: protocol/study design, site qualification, in-house image QC, independent image reading and analysis, data reconciliation and export, final image archival, regulatory support and submission. Our scientific expertise together with sophisticated technologies help clients successfully navigate from protocol design all the way to FDA submissions. PharmaLegacy Laboratories Shanghai, China Booth # 219 PharmaLegacy is a preclinical specialty CRO that has strong track records in services to worldwide companies committing R & D in therapeutics for Bone Safety/ Metabolism/Orthopaedics and Tissue Engineering, besides Immune Diseases/Inflammation and Tumor. We provide quality, timely and cost saving execution for experiments under GLP operation and AAALAC certification. Pharmatest Services Turku, Finland Booth # 302 Pharmatest provides clinically predictive and cost-efficient solutions for preclinical drug development and lead validation services to Pharmaceutical and chemical industries. Partnering with Pharmatest will significantly decrease efficacy-related attrition in clinical trials, lower your fixed research costs and increase the speed of your preclinical research. We specialize in therapeutic areas with unmet clinical needs. Quidel Corporation San Diego, California, USA Booth # 311 The QuidelH Specialty Products Group identifies, develops, manufactures and markets unique diagnostic and research assays and reagents with applications in bone health, inflammatory diseases and oncology. Our kits and reagents are marketed worldwide under the QuidelH and MicroVueTM brands. Ratoc System Engineering Co., Ltd. Tokyo, Bunkyo-ku, Japan Booth # 134 TRI/3D-BON, 3D analysis software, performs bone analysis: separating trabecular and cortical bones and measuring 3D morphometry and its strength from DICOM file and CT image. These results assist you in dealing with diagnosis of osteoporosis progress and medication effects. Research Diets Inc. New Brunswick, New Jersey, USA Booth # 205 Research Diets, Inc. formulates and produces purified OpenSource DietsTM for laboratory animals. Our nutritionists consult on custom diet formulations. The BioDAQH Food & Liquid Intake Monitor controls spillage, mounts to home cages, and records the time, duration, and amount of each meal automatically. Data is interpreted using our DataViewer software.

306

Scanco Medical Zurich, Switzerland Booth # 301 Scanco Medical (www.microCT.com) is the leading global provider of mCT and XtremeCT (HRpQCT) scanners. Scanco also provides contract based scanning services for non-destructive scanning applications. The range of scanners offer capabilities of obtaining 3-dimensional images under 1 micron resolution capability with density calibration, short scan times and high-throughput (built-in carousel). SkyScan US San Jose, California, USA Booth # 406 SkyScan is a fast growing company and one of the worlds leading producers of micro-ct systems for a wide range of applications. SkyScan aims to bring to customers the newest technology, the best instrument quality and the highest level of support. Responding to the demand from the growing community of micro-CT users, we are continually active in research and development into new methods for non-destructive 3D microscopy.

Thomson Reuters Carlsbad, California, USA Booth # 501 Advance research and publishing with integrated solutions from Thomson Reuters. EndNote enables collaboration and instant bibliography creation for research papers. Web of Knowledge supports researchers with authoritative content for discovery and analysis. ResearcherID is a free author community for listing personal publications. ScienceWatch.com features trends discovered in the literature. Warner Chilcott Rockaway, New Jersey, USA Booth # 211 Warner Chilcott is a leading specialty pharmaceutical company currently focused on the gastroenterology, women’s healthcare, dermatology and urology segments of the North American and Western European pharmaceuticals markets. The Company is a fully integrated company with internal resources dedicated to the development, manufacturing and promotion of its products. Wiley-Blackwell Hoboken, New Jersey, USA Booth # 332 Wiley-Blackwell is the international scientific, technical, medical and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the worlds leading societies. Wiley-Blackwell publishes the JBMR and the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism on behalf of the ASBMR. For more information, please visit www.wileyblackwell.com or http://onlinelibrary.wiley.com. Xradia, Inc. Pleasanton, California, USA Booth # 434 High-resolution, high-contrast, non-destructive 3D X-ray microscopes enabling advanced research applications into the submicron to 50-nm range. The VersaXRM and UltraXRM offer the best performance for imaging complex hierarchical bone structures including microstructure, fine structure, nanostructure. For hard and soft tissues, from single-cell imaging to complete views of fully developed organisms.

307

Exhibits

Springer New York, New York, USA Booth # 325 Springer offers cutting-edge publications including Osteoporosis (Adler), Vitamin D, Second Edition (Holick), Bone Densitometry in Clinical Practice, Third Edition (Bonnick), Primer on the Rheumatic Diseases (Klippel et al.), Journal of Bone and Mineral Metabolism, Osteoporosis International, Calcified Tissue International, and Clinical Orthopaedics and Related Research.

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A

Author Index

1005, MO0123, MO0279, MO0287, SA0275 Aguirre, J. Ignacio FR0152, SA0152, SU0105 Aguirre, M. SU0332 Ahasan, M. SA0480 Ahmadian, L. SU0365 Ahmed, L. 1130 Ahmed, M. MO0440 Ahn, Y. MO0379 Aiba, A. SU0090 Aido, M. I. 1106 Aizawa, R. SU0090 Aizawa, T. SA0426 Ajibade, D. SA0488 Akazawa, H. SU0205 Akel, N. S. MO0015 Akesson, K. FR0327, MO0367, SA0327, SA0363 Akhigbe, T. SA0373, SU0363 Akhter, M. MO0096, MO0318, SA0152, SA0234, SU0105, SU0311, SU0320 Akihisa, T. SU0205 Akintoye, S. O. SU0259 Akiyama, H. 1009 Akkiraju, H. 1198, SU0200 Akram, M. SU0327 Aktuglu, K. MO0387 Akune, T. 1011, MO0385, SU0378 Al-Daghri, N. SU0159 Al-Dujaili, S. FR0281, SA0281 Al-Shamsi, H. SU0136 Alaee, F. MO0312 Alam, I. MO0196 Alarcon, C. 1172 Albagha, O. M. E. SA0358, SU0165 Albanell, J. MO0131, SU0140 Alberghini, M. SU0144 Alekna, V. MO0013, SA0321 Alex, C. SU0182, SU0359 Alexander, B. SU0395 Alexander, I. FR0157 Alfonso, H. SU0009 Alford, A. I. MO0113 Alias, E. MO0283 Alibhai, S. SU0338 Allanore, Y. MO0034 Allaoui, S. SA0042 Allen, M. 1043 Allen, M. R. MO0045, MO0074, MO0149 Alles, N. MO0221 Alley, D. MO0374 Allison, J. 1177 Allison, M. MO0426 Alliston, T. N. 1125, FR0092, SA0034, SA0216, SU0116 Alman, B. A. FR0063 Almeida, M. 1110, 1168, 1189, FR0002, MO0476, SU0128, SU0470 Almeida, M. S. 1160 Almeida, O. SU0009 Alos, N. FR0030, SA0019, SA0030 Alsami, L. MO0205 Alsharif, N. SA0301 313

Index

Aalto, V. 1084 Aati, O. MO0156 Abboud Werner, S. L. MO0308, SA0408 Abdallah, B. M. SU0242, SU0250 Abdelgawad, M. 1170 Abe, M. 1229, FR0106, SA0143 Abe, Y. MO0358, SA0381 Abed, E. FR0233, SA0233 Abel, T. MO0300, SU0280 Abhold, E. SU0141 Abiko, Y. MO0105 Aboody, K. MO0140 Abou-Samra, A. SU0254 Abou-Samra, A. B. SA0124 Aboulafia, A. MO0132 Abraham, S. 1159 Abrahamsen, B. MO0186, MO0325, MO0442, SA0427 Abrahamson, M. MO0271 Abu Alfa, A. FR0423 Abu-Amer, Y. MO0305 Aburatani, H. SU0309 Acerbo, A. MO0057, SU0061 Acevedo, D. SA0494 Achenbach, S. MO0354 Achilleos, A. SU0005 Achiou, Z. MO0060 Acitores, A. MO0007 Ackert-Bicknell, C. L. MO0197, SU0101 Adachi, J. 1062 Adachi, J. D. 1024, 1055, FR0384, MO0011, MO0073, MO0328, MO0377, MO0453, SA0357, SA0377, SA0420, SA0429, SA0444, SU0136, SU0173, SU0380, SU0405 Adachi, T. MO0067 Adamczyk, P. SU0343 Adami, S. SU0441 Adamo, M. MO0017, MO0018 Adamopoulos, I. E. SU0276 Adams, D. J. 1005, 1228, MO0069, SA0237 Adams, J. 1116, MO0429, SA0128, SU0443 Adams, J. E. SA0028 Adams, J. S. MO0480, MO0484, SU0495 Adapala, N. FR0305, SA0305 Adekunle, F. SA0351 Adhami, M. SA0231 Adhikari, R. SU0285 Adler, B. J. SA0046, SU0151, SU0207, SU0264 Adler, R. A. SU0342 Adrian, M. SU0130 Aeberli, D. SU0106 Aeschlimann, D. MO0104 Agca, C. MO0404 Agca, Y. MO0404 Agellon, S. 1140, MO0340 Ager, J. 1108, SA0034 Aghaloo, T. L. 1226, SU0292 Agnidis, Z. SU0452 Agrawal, D. Kumar MO0486, SA0486 Agrawal, T. MO0486, SA0486

Aguila, H. L.

Alvarez, G. K. SA0234, SU0311 Alvarez, J. MO0124 Alvarez, L. MO0232 Alvarez, M. B. SU0260 Alwood, J. Stewart MO0285, SU0286 Amagasa, T. SA0102 Amano, A. SA0248 Amano, K. 1155 Amati, F. MO0347, SA0388 Ambe, K. SA0107, SU0086 Ambrogini, E. 1110, 1168, 1189, MO0476 Amend, S. Rebecca SA0295 Ameye, L. SA0450 Amin, N. 1084, SA0358, SU0367 Amin, S. 1095, 1176, MO0354, SA0389, SU0054 Amizuka, N. MO0095, MO0315 Amling, M. 1108, SA0189, SU0033 Ammann, P. 1070, SA0056 Ammentorp, J. SU0444 Amrein, K. MO0428, SA0424, SU0055, SU0346 Amrein, S. SU0346 Amugongo, S. SA0467 Amugongo, S. Kigamwa SU0045 An, J. FR0269, FR0392, SA0269, SA0376 An, Q. SA0207 Anastassiades, T. P. SU0350 Andersen, T. Levin 1170, 1173 Anderson, D. Earl FR0013, SA0013 Anderson, J. 1090, SU0154 Anderson, M. MO0132, SU0065, SU0079 Anderson, P. Hamill FR0493, SA0493 Andersson, A. MO0479 Andersson, G. MO0070 Andersson, N. U SU0483 Andersson, S. MO0407 Andrade, R. MO0203 Andre, P. FR0095 Andresen, R. SA0435, SU0454 Andrews, F. SA0241 Andrukhova, O. FR0120, SA0120 Ang, E. SA0297, SA0302 Anto´n, I. 1232 Antal, M. FR0482 Antunez, O. 1066 Aoki, K. MO0221 Aonuma, H. SU0475 Aoyagi, K. MO0358, SA0381 Aoyama, E. FR0090 Arabian, A. 1113 Aragaki, A. 1020, MO0373, SU0352, SU0369 Arakawa, C. MO0216 Arantes, H. Pierotti FR0195 Arasu, A. FR0411, SA0411 Ardeshirpour, L. 1053 Arellano, G. FR0253 Arezzo, J. MO0006 Argente, J. MO0024 Arimoto, T. SU0293 Arjmandi, B. H. SU0104, SU0160, SU0413 Arkela-Kautiainen, M. MO0047 Armamento-Villareal, R. 1164 314

Armas, L. A. G. SA0060 Armbruster, F. MO0009 Arnett, T. R. SU0222 Arnold, A. SU0172 Arnold, C. SU0015 Aro, H. T. FR0421, SA0421 Aronson, J. SU0146 Arora, P. MO0341 Arora, P. S. FR0411 Arora, T. MO0439 Arts, C. SA0337 Aruwajoye, O. MO0074 Aryal A.c, S. 1258 Asai, K. SA0278 Asai, S. 1195 Asaka, I. SU0187 Asano, S. MO0324, SA0324, SU0119 Asaoka, K. 1229 Asashima, M. SA0200 Ascenzi, M. 1226, SU0062 Ashley, J. Waid FR0290, SA0272 Ashraf, A. MO0124 Ashton, J. MO0146 Askmyr, M. MO0154, SA0298 Asmawidjaja, P. SA0277 Asou, Y. MO0090, SA0068 Aspden, R. M. MO0031 Aspelund, T. 1084, SA0382 Asplin, D. MO0121 Asplin, J. MO0121 Assis, G. MO0203 Asuncion, F. J. 1206 Aswath, P. MO0074 Atamaz Calis, F. MO0387 Athanasou, N. A. SA0282 Atkins, G. J. 1042, SA0493 Atkinson, C. 1139 Atkinson, E. 1095, 1176, MO0354, SA0389 Atkinson, S. FR0030, SA0019 Atkinson, S. A. SU0405 Atsali, E. SA0452 Attar-Namdar, M. SU0226, SU0392 Aubin, J. E. 1016, 1182, 1234, MO0280, SA0121, SA0484 Aubry-Rozier, B. MO0162 Aucott, L. SA0457 Audran, M. J.V. MO0189, SU0082 Augat, P. MO0010 Aula, A. SA0108 Aurora, R. 1015 Austin, A. MO0116 Austin, M. 1063, 1064, FR0446 Austin, N. Patrick SA0420 Avanzati, A. MO0393 Aveline, P. MO0043 Avlani, V. A MO0474 Avorn, J. SU0437 Avram, V. SU0405 Aya, K. SU0202 Aydogdu, S. MO0387 Aymar, I. SA0447 Ayuk, J. SU0158 Ayukawa, Y. SU0284, SU0287 Author Index

Azeddine, B. Azizi, T. Azzam, E.

MO0475 1221 1081, MO0314

B

Author Index

SA0089 SU0089 SU0024 MO0145 SA0362 MO0487, SA0162, SU0491 MO0487 MO0136, MO0137, SA0133, SA0135, SU0235 Banka, S. MO0473 Banti, C. SA0172, SU0169 Banu, J. MO0466 Banzer, J. SA0435, SU0454 Baptista, F. SU0026 Bar, A. SU0392 Barbara, A. SU0476 Barbe, M. F. SA0305 Barber, A. SA0045 Barbosa, A. MO0390, SU0440 Barbour, K. E. 1022 Barbu, C. Gabriela SA0422 Barbu, D. SA0422 Barbu, H. Mihail MO0392 Barbuto, N. MO0413 Barengolts, E. MO0388 Baret, S. SU0135 Barhanpurkar, A. MO0265 Baricich, A. SU0416 Barkaoui, A. MO0033, MO0062 Barkema, D. SA0338 Barlogie, B. MO0145 Barnard, K. SA0440 Barnes, A. SA0171 Barnes, S. MO0477 Baron, R. 1003, 1034, 1037, 1047, 1145, FR0131, MO0272, SA0274 Barr, R. MO0031 Barreira, J. SU0164 Barrett, B. MO0029 Barrett-Connor, E. L. SA0378 Barry, K. 1037, 1051, SA0315 Barsony, J. 1169 Bartell, S. 1110, 1168, 1189, FR0002, MO0476, SA0002, SU0470 Bartell, S. M. 1160 Bartels, A. SA0243 Bartelt, A. SA0189, SU0003 Barth, H. 1108, SA0034 Bartold, P. SA0181, SU0300 Bartoletti, M. MO0436, SU0432 Basel, D. MO0139, SA0136, SU0142 Basi, D. SU0153 Bass, M. MO0248 Bassett, J. SA0045 Bassilana, F. MO0307 Bastepe, M. SA0130 Bastos, A. MO0274 Bateman, T. A. SU0316 Batra, N. FR0073, SA0073 Battaglino, R. A. MO0063, MO0290, SU0301, SU0466 Bauer, D. C. 1212, MO0384, MO0424, SA0173, SU0167, SU0348, SU0422, SU0448 315

Index

Bo¨rst, H. MO0455 Bo¨ttcher, R. SA0102 B. Sardinha, L. SU0026 Bab, I. A. SU0226, SU0392 Baba, K. SU0263 Baba, T. MO0427 Babajko, S. MO0098, SU0098 Babey, M. SU0071 Babij, P. MO0248 Baca-Asher, J. SU0019 Bacabac, R. MO0067 Bach-Gansmo, F. MO0080 Bachar, M. SU0392 Badger, T. MO0262, SA0023 Badiei, A. SA0314, SA0316 Bae, J. FR0231, SA0231 Bae, S. MO0087, MO0219, MO0236, SU0425 Bae, W. MO0336 Bae, Y. 1085, MO0246 Baek, D. SU0436 Baek, J. FR0187, SA0251, SU0201 Baek, K. FR0187, SA0251, SA0341, SU0375 Baek, W. FR0392, SU0215 Baessgen, K. MO0130 Bagur, A. SU0344 Bahadur, A. N. MO0466 Bahar, H. FR0131, SA0131 Bahl, A. FR0475 Bai, J. SA0105 Bai, X. SU0118 Baik, A. SU0315 Baik, J. SU0209 Bailey, C. 1166 Baim, S. SA0494 Bain, S. SA0007, SU0228 Bajayo, A. SU0226, SU0392 Bak, H. SA0460, SU0324 Baker, A. Rachel Haas FR0241, SA0241 Baker, E. MO0154, SU0148 Baker, S. MO0058 Bakhshalian, N. SU0104 Bakker, A. MO0067, MO0310, SA0495, SU0313 Bala, Y. FR0062, SA0062 Balasubramanian, A. MO0435, SU0443 Balcells, M. SA0315 Balcells, S. MO0284 Baldassano, R. SA0029 Baldock, P. MO0233 Baldock, P. A. 1002, FR0157 Baldridge, D. MO0107, MO0246 Bale, H. 1108, SA0034 Balian, G. FR0268 Balid, A. SU0286 Ball, C. Ann SU0182 Balla, B. MO0180

Ballock, R. Ballock, R. T. Baltgalvis, K. Bam, R. Bancej, C. Bandeira, F. Bandeira, L. Baniwal, S. K.

Bauer, W. Baum, T. Bausell, R. Baxter-Jones, A. Baxter-Jones, A. D.G.

1074 FR0061, SA0049 MO0332 SA0051 1175, SU0015, SU0479 Bay-Jensen, A. SA0117 Bayer, M. MO0028 Baylink, D. J. 1038, 1071, 1078, 1221, FR0319, MO0470 Bayoumi, A. SU0452 Bazalova, M. SA0150 Beachy, J. MO0029 Beale, C. MO0231 Beamer, W. MO0222 Beamer, W. G. SU0151 Beasley, T. MO0124 Beaton, D. SA0436 Beattie, K. A. MO0011, SA0357, SU0405 Beaucage, K. Lee MO0101 Beaulieu, M. MO0355, MO0355 Beause´jour, C. SA0264, SA0265 Beck Jensen, J. FR0446, MO0125 Beck, T. J. 1096, MO0071, MO0073, SA0033, SA0033, SU0336 Becker, D. James MO0439, SU0427 Becker, M. MO0146 Beckwith, R. MO0463 Becton, D. SU0146 Bedell, V. SU0091 Bedi, B. 1116, FR0128, SA0128 Beer, C. SU0009 Begum, S. MO0169 Begun, D. FR0074, SA0081 Beham.schmid, C. SU0055 Behera, A. MO0174 Behets, C. 1070 Behre, C. SA0010 Behrmann, A. SA0160 Beier, F. MO0092 Beil, F. SA0189 Bekaert, A. SA0490 Belanger, A. MO0331 Belcher, J. Y. FR0291 Belev, G. SU0073 Belghali, S. SU0388 Belknap, S. FR0423 Bell, A. MO0328 Bellahcene, A. 1234 Bellerose, D. 1136 Bellido, T. M. 1035, 1050, 1067, SU0316 Belsky, J. MO0192 Belury, M. MO0373, SU0352 Belzile, E. 1260 Bemben, D. A. SU0034, SU0065, SU0453 Bemben, M. G. SU0065, SU0453 Bendele, A. SU0474 Beneton, M. MO0358 Benhamou, C. MO0043, MO0060, MO0062, SA0402, SU0068 Benisch, P. MO0001 Benito, J. FR0066 Benjamin, A. MO0388 316

Benjamin, E. Bennet, P. Bennett, B. Benoist, C. Benson, J. Beraudi, A. Berdal, A.

MO0198 MO0437 SA0245 1018 1035, 1050, 1067 SU0084 MO0098, SA0112, SA0243, SU0098 Berenbaum, F. SU0468 Berg, J. SU0097 Berg, R. 1131, SU0195 Berger, C. 1055, FR0384, MO0009, SA0384, SU0173, SU0350, SU0370 Berglund, L. 1243 Bergman, C. SU0258 Bergmann, S. SU0457 Bergson, C. MO0258 Bergstro¨m, I. SA0491 Bergstralh, E. MO0188 Berman, B. MO0136, SA0133 Berman, E. 1231 Bermeo-Serrato, S. SU0208 Bernard, J. MO0220 Bernard, P. J. 1177, SU0028 Bernieri, J. SU0322 Bernstein, C. SU0347 Bernstein, G. MO0049 Berry, J. MO0169 Berry, S. FR0380, SA0380 Berryhill, S. 1209 Bertholon, C. MO0078, MO0320 Berti, P. MO0165, SU0169 Bertin, P. SU0329 Bertin, T. 1083, 1085, MO0100, MO0107, MO0246, SU0093 Besjakov, J. FR0327 Bessette, L. 1260 Bessho, M. SA0054 Bessler, M. SU0179 Bethel, M. SU0304 Bettamer, A. Omar MO0033, MO0062, SA0042 Bevilacqua, M. SU0416 Beyene, J. SU0338 Bezouglaia, O. FR0253, SU0292 Bhadada, S. MO0174 Bhagat, Y. MO0183 Bhamidi, P. SA0144 Bhansali, A. MO0174 Bhargava, A. MO0011, SA0357 Bhattacharyya, N. SA0031, SA0122, SU0157 Bhuva, S. SA0338 Bicho, M. MO0390, SU0440 Bidwell, J. P. SU0260 Bikle, D. 1049, FR0214, SU0071 Bikle, D. D. 1053, MO0085, SA0488 Bilezikian, J. 1064, 1097, 1211, FR0195, MO0036, MO0044, MO0172, MO0261, MO0414, SA0173, SA0195, SU0046, SU0062, SU0167 Binder, N. SU0210 Binkley, N. 1134, 1203, FR0330, FR0453, MO0012, MO0454, SA0350, SA0453, SU0006 Author Index

Author Index

Bolognese, M. 1061, 1203, MO0442 Bolognese, M. A. 1134 Bonar, S. 1115, 1256 Bone Group, S. MO0456 Bone, D. SU0184 Bone, H. 1063, 1065, MO0442 Bone, H. G. FR0453 Bonewald, L. F. 1037, 1038, 1068, 1071, FR0005, FR0073, FR0235, FR0319, MO0005, MO0118, MO0313, MO0319, SA0310, SA0313, SU0001, SU0005, SU0312, SU0317, SU0393 Bonjour, J. MO0380 Bonnelye, E. 1234 Bonnet, C. SU0329 Bonnet, N. 1236, SU0113 Bonnyman, A. SA0333 Bonor, J. 1198, SU0200 Boonen, H. SA0460, SU0324 Boonen, S. 1024, 1066, 1248, FR0449, MO0369, MO0377, MO0424, MO0442, SA0377, SU0054, SU0428, SU0455 Boras-Granic, K. SU0126 Borderie, D. SA0167 Borel, O. MO0320 Borges, c. MO0487 Borggrefe, J. SA0036 Borjesson, A. E. FR0482, MO0479, SA0482, SU0483 Bornstein, S. A. 1034, 1213 Borsari, S. MO0165, SA0172, SU0169 Boskey, A. MO0058 Boskey, A. L. MO0158, SA0083, SA0084 Boss, G. MO0245, SU0480 Bostrom, M. MO0066 Botros, M. SU0207 Bou-Said, B. SU0051 Bouazza, L. 1234 Boudenot, A. SU0068 Boudreau, D. SA0352 Boudreau, R. 1019, MO0347, SA0388 Bougneres, C. MO0437 Bouhaddi, M. MO0181 Boulanger, J. 1124 Bournazos, I. SA0452 Bours, S. 1262, SA0337 Boutroy, S. 1092, MO0332, MO0413, MO0414, SA0041, SA0047, SU0057, SU0327, SU0328, SU0403, SU0414, SU0430 Boutsen, Y. MO0420 Bouvard, B. SU0082 Bouxsein, M. MO0464 Bouxsein, M. L. 1034, 1069, 1213, FR0013, FR0025, FR0131, FR0347, FR0383, MO0348, SA0038, SA0365, SU0036, SU0043, SU0076 Bowman, E. SU0276 Bowman, S. SA0032 Bowser, M. SA0001 Boyce, A. SA0031 Boyce, B. F. 1233, 1254, MO0141, SU0306 Boyd, G. SU0047 Boyd, S. K. 1064, SU0037, SU0050 Boyde, A. SA0045, SU0107 317

Index

Binns, C. MO0345 Biosse Duplan, M. FR0274, SA0274 Birch, M. SA0301 Birke, O. FR0465 Birkedal, H. MO0080 Birkhead, J. MO0082 Birkhold, A. 1106 Bischoff, D. FR0205, SA0205 Bishop, K. FR0095, SA0487 Biswas, R. MO0336 Bittighofer, C. FR0332, FR0418, MO0397, SA0043, SU0333, SU0418 Bivi, N. 1035, 1050, 1067 ˚. Bjørnerem, A 1130 Bla´zquez, G. MO0196 Black, A. J. SA0457 Black, D. M. 1241, 1248, 1250, MO0412, MO0424, SA0036, SA0354, SU0422, SU0428 Blackburn, M. MO0262, SA0023 Blain, H. MO0403 Blair, J. SA0024 Blaizot, S. SU0403 Blake, E. MO0069 Blake, G. FR0419, MO0422 Blanch, J. SU0140 Blanchette, C. SA0093 Blanck, A. SA0491 Blangero, J. 1144, MO0195 Blangy, A. MO0273 Blank, R. D. SA0032, SU0072 Blattert, T. R MO0451 Blew, R. MO0026 Bliuc, D. 1130, 1259, FR0353 Blomhoff, R. SA0386 Blommers, M. MO0463 Blomqvist, C. MO0134 Bloom, A. MO0104, MO0281 Bloomfield, S. A. 1238, MO0149, MO0227, SA0040, SA0226 Bloot, R. 1142 Boadle, R. SA0218 Boardman, D. SA0354 Bober, M. B. MO0030 Bock, O. MO0455 Bockman, R. S. 1137 Boeckhof, J. SA0437 Boernert, K. SA0136 Boetto, J. SA0484 Bogado, C. E. SA0047, SA0396 Bogado, C. Ernesto MO0061 Bogers, J. SU0144 Bogner, E. SA0335 Bogoch, E. SA0436 Bohnert, K. SU0210 Boire, G. MO0355 Boisseau, N. SA0402 Boivin, G. FR0062, MO0078, MO0394, SA0451 Bokhari, R. SA0081 Boland, A. SA0198 Bolean, M. MO0081, MO0102, SU0109 Bollag, W. MO0258, SA0286 Bollerslev, J. 1170

Boyle, C. Bra¨nstro¨m, R. Bru¨el, A.

MO0231 SU0394 MO0080, MO0171, MO0459, SU0041 Bru¨el, M. SA0298 Braby, L. MO0149 Brachvogel, B. MO0095 Bracken, C. 1124, FR0177 Bradley, E. W. FR0086, SA0086 Bradsher, R. FR0002, SU0470 Braga, T. SA0361, SU0345 Bragdon, B. C. SU0200 Brandao-Burch, A. SU0222 Brandi, M. 1065, MO0226, MO0268, SA0159, SA0358 Brankin, E. SA0351, SU0426 Brask-Lindemann, D. MO0325 Braun, R. SU0101 Bravenboer, N. SA0397, SA0495 Bravo Martin, A. MO0394 Bravo, B. SA0308 Bravo, Y. SA0186 Bray, G. SU0400 Bredbenner, T. L. MO0037, SU0048 Breggia, A. C. 1196 Brehar, A. MO0392 Brennan, H. 1257 Brennan, S. SA0481, SU0341 Brennan-Speranza, T. C. 1109 Brenneman, S. MO0441, SA0445 Brentjens, R. 1231 Brett, A. SA0335 Brianza, S. SA0035 Bridges, D. MO0055 Brillante, B. SU0123 Brimer, D. MO0048, SU0038 Bringhurst, F. FR0131, MO0126 Brito, G. MO0488, MO0490 Britz, H. SU0073 Brixen, K. MO0125, MO0186, SU0444 Broadus, A. E. 1153 Brodt, M. 1235 Broe, K. E. FR0383, MO0348, SA0365 Brommage, R. 1044, 1172 Brookhart, A. MO0435, SU0437 Brotto, L. MO0005 Brotto, M. FR0005, MO0005, SU0001 Browett, P. MO0156 Brown, A. J. SA0123, SU0493 Brown, E. M. 1052 Brown, J. 1063, 1065, 1203, FR0446, SA0446 Brown, J. P. 1055, 1251, 1260, FR0384, MO0073, MO0189, MO0331, SA0362, SU0173 Brown, K. MO0345, SU0154 Brown, M. SA0045, SA0076, SA0358, SA0483 Brown, R. SU0430 Brown, S. SA0045 Browne, J. SU0331 Brownell, N. SU0289 Brum, P. 1072 Brun, L. 1035 318

Brune, K. MO0147, SU0461 Brunet, L. 1033 Brunetti, G. SA0149 Bruno, A. FR0013 Bruns, O. SU0003 Bruzzaniti, A. 1043, FR0307, SU0304 Brydges, S. 1115 Bryk, G. MO0490, SU0398 Brynildsen, W. SA0456 Bu, F. FR0492 Buaas, F. SU0101 Buben, C. SU0445 Buchinger, B. MO0411, SU0035 Buchman, S. SU0155 Buchwald, H. MO0071 Bucknell, A. SU0112 Buczkowski, T. 1214 Budayr, A. A. SU0458 Buehring, B. MO0012, SU0006 Buijs, J. Theodorus SU0316 Bull, C. MO0147, SU0461 Bullens, S. 1018 Bunker, C. SA0364 Bunting, S. 1018 Burden, A. M. SU0431 Burge, R. SA0356 Burgers, T. SA0097 Burghardt, A. J. MO0049, MO0412, SA0047, SU0077 Burghardt, I. MO0257 Burket, J. Carolynn MO0058 Burkett, M. SU0152 Burkhart, M. 1236 Burnei, C. SA0422 Burnett-Bowie, S. M. 1101 Burns, S. SA0373, SU0363 Burns, T. MO0046 Burr, D. B. MO0045, SU0234 Burra, S. FR0073 Burridge, K. FR0072 Burroughs, D. MO0398 Burt, L. SU0023 Burton, D. W. SA0151, SA0153, SA0313, SU0141 Bushinsky, D. A. MO0121, SU0161, SU0255 Busse, B. 1108, SA0034, SU0049 Bussolati, B. SU0134 Butler, D. MO0256 Buttazzoni, C. FR0020 Buttazzoni, m. SA0396 Buttgereit, F. MO0139, SA0136 Byberg, L. 1243, SU0354 Bydder, G. MO0336 Byun, D. SA0398

C Coˆte´, P. Can˜ete, T. Cabal, A. Cabana, F. Cabral, D. Cabral, W.

MO0355 MO0196 MO0037, SU0066 MO0355 FR0030, SA0019 1015, MO0158, SU0189 Author Index

Cabral, m. Cadarette, S. M. Caeiro, J. Caeiro, J. R. Caetano, P. Caffarelli, C. Cagen, R. Cai, Q. Cain, M. Caird, M. Calabro`, A. Calderon, A. Callaci, J. J. Callon, K. Callreus, M. Calvano, D. Calvi, L. M. Camacho, P. M.

Author Index

Carey, V. SU0400 Carli, A. MO0475 Carlisi, A. SA0490 Carlos, A. SU0192 Carlson, C. SU0369 Carlson, N. SA0012 Carlsten, H. MO0479 Carmel, A. 1137 Carmeliet, G. J. V. FR0235, SA0262, SU0135 Carney, G. SU0436 Carossino, A. MO0268 Carpenter, D. FR0061, SA0061 Carpentier, V. SA0314, SA0316 Carrelli, A. Lisa SU0179 Carrello, A. SA0302 Carriero, A. 1108, SU0049 Carrillo-Lo´pez, N. SU0176 Cars, T. 1243 Carson, A. SU0387 Carson, D. D. SU0138 Carter, C. 1043 Carter, S. SU0018 Carter, Y. SA0057, SU0073 Carvalho, E. SU0491 Casado, E. SU0420 Casado-Dı´az, A. SU0261 Casazza, K. MO0022, MO0124 Case, N. D. 1240, FR0072, SU0074 Casentini, C. SA0159 Casey, M. MO0323, SU0331, SU0415 Casey, V. MO0352 Caspari, R. SA0081 Castadena, b. SA0112 Castagneto, J. MO0027 Castagnola, P. 1181 Castano-Betancourt, M. SA0368, SU0198 Casteel, D. MO0245 Castillo, A. B. FR0078 Castro, C. SA0008 Castro, M. MO0167 Castronovo, V. 1234 Cattini, L. MO0230 Cauley, J. A. 1019, 1023, 1058, 1084, 1093, 1094, 1241, 1242, 1248, 1263, FR0359, FR0411, MO0039, MO0343, MO0347, MO0349, MO0382, SA0358, SA0359, SA0388, SU0008, SU0336, SU0367, SU0372, SU0450 Cavalier, E. SA0490, SU0171 Cavalli, L. SA0159 Caverzasio, J. SA0254 Cawthon, P. M. FR0411, MO0384, SA0359, SU0008, SU0358 Cazer, P. 1039, 1041, FR0409 Ceccarelli, E. SA0394 Celi, M. MO0051 Censani, M. SA0018 Center, J. R. 1130, 1259, FR0353, MO0368, MO0378, MO0402, SA0339, SA0375 Cerocchi, I. MO0051 Cetani, F. MO0165, SA0172, SU0169 Cha, C. SU0362 Cha, M. SU0366 Cha, S. MO0019 319

Index

MO0487 MO0325, SU0431, SU0436 SU0462 SA0101 SU0355 MO0337 1086 SU0443 MO0258 1185 MO0393, SA0394 SA0456 SU0223 MO0156, MO0211, SA0105 MO0367, SA0363 SU0251 MO0146, SA0129, SU0212 MO0166, SA0428, SU0182, SU0359 Camp, J. SA0389 Camp, K. MO0149, MO0227, SA0226 Campagna, M. MO0393 Campagna, S. MO0337 Campbell, G. MO0453 Campbell, J. MO0410, SU0417 Campbell, J. Preston SA0132 Campbell, S. SU0104, SU0413 Campeau, P. MO0246 Campisi, G. SU0446 Canadian Stopp Consortium, FR0030, SA0019 Canaff, L. SU0233, SU0256 Canalis, E. 1010, 1033, 1253, SU0225 Candas, B. 1260 Candelario, J. SU0231 Cannata Andia, J. B. SU0176, SU0349 Cantley, M. Danielle SA0181, SU0300 Cao, H. 1046, MO0239, SU0490 Cao, J. MO0083, MO0248, SU0230 Cao, J. J. SA0470, SU0053 Cao, S. SA0256 Cao, X. 1006, 1193, MO0127 Cao, Z. MO0112 Capannolo, M. 1028, 1089 Caparbo, V. MO0363, SU0362 Capelo, L. MO0200 Capietto, A. 1087 Capodarca, C. SA0394 Capozza, R. SU0078 Cappariello, A. 1028, SU0216 Capulli, M. 1089 Carballido-Gamio, J. SU0077 Carbone, C. MO0436, SU0432 Carbone, L. D. SA0373, SU0363 Carbonell, C. FR0385, SA0447 Carbonneau, C. SA0264, SA0265 Carcasse`s, V. SU0329 Carda, S. SU0416 Cardadeiro, G. SU0026 Cardelli, M. SA0484 Cardew, S. SA0420 Carew, S. SA0184 Carey, H. SU0285

Chachisvilis, M. SU0231 Chae, T. SU0313 Chahine, N. SA0093 Chaichanasakul, T. SU0292 Chakkalakal, S. Anandan SU0095 Chale`s, G. SU0243 Chalberg, C. SA0313 Chamberlain, C. SA0031 Chambers, T. J. SU0274, SU0474 Chambliss, K. SU0470 Chambon, P. FR0482, MO0479 Chan, B. Y. SU0232 Chan, C. SU0415 Chan, E. MO0065, SA0046, SU0151, SU0207, SU0264 Chan, H. MO0159, SU0269 Chan, L. MO0448 Chan, M. MO0378, SA0339 Chan, R. SU0125 Chan, T. FR0233 Chan, Y. MO0042, SU0064 Chandler, J. M. SA0354 Chandra, A. MO0129 Chandra, M. SU0458 Chang, C. SA0345 Chang, J. MO0356, SU0361, SU0424, SU0434 Chang, M. 1040, SA0128, SA0468 Chang, W. 1049, 1053, 1146, FR0214, MO0085, SU0377 Chanjaplammootil, S. SA0470 Chao, C. SU0276 Chao, T. SU0271 Chapelle, J. SA0490 Chappard, D. SU0082 Chappel, J. FR0299, SA0296 Chapurlat, R. 1036, 1064, 1065, MO0403, MO0442, MO0464, SA0041, SU0057, SU0388 Chapurlat, R. D. FR0062, MO0078, MO0377, MO0394, MO0401, SA0047, SA0377, SA0444, SU0051, SU0403 Charles, J. F. FR0284, SA0284 Charlesworth, D. MO0358, SA0328 Chasman, D. 1084, SA0358 Chatani, M. FR0292, SA0292 Chaubey, A. MO0256 Chaudhry, M. SU0175 Chavassieux, P. MO0403, MO0464 Chavassieux, P. M. SA0430 Chaves, N. MO0487 Checovich, M. M. FR0330 Chee, W. SA0450 Cheetham, T. SU0439 Chen, C. SA0216 Chen, C. Mengmeng MO0472 Chen, D. 1008, 1223, 1233, FR0215, MO0298, SU0157, SU0411 Chen, F. Huey 1182 Chen, H. MO0243, MO0304, MO0480, SA0231 Chen, I. MO0159, MO0187, SU0269 Chen, J. FR0023, MO0069, MO0123, MO0262, SA0023, SA0469 320

Chen, L. SA0434, SU0242 Chen, M. 1037, SU0245 Chen, P. 1200, 1202, MO0391, SA0117, SA0415, SU0179, SU0340, SU0371, SU0414, SU0430 Chen, Q. 1225 Chen, R. SA0229 Chen, S. 1013, 1085, 1186, MO0107, SA0015, SA0222, SU0093 Chen, T. 1146 Chen, W. FR0293, SA0293, SA0304 Chen, X. 1073, 1165, MO0042, MO0255, SU0372 Chen, Y. MO0107, MO0197, MO0246 Chen, Z. MO0026 Cheng, E. MO0132 Cheng, H. SU0183 Cheng, J. SU0060, SU0339 Cheng, S. 1118, MO0254, SA0160, SA0358, SU0411 Cheng, T. FR0157, MO0300, MO0301, SA0297, SA0302 Cheng, X. MO0450, SA0282 Cheng, Y. SU0304 Cheng, Z. 1049, 1146, MO0085, SA0467 Chenu, C. 1215 Cherman, N. SA0031 Chernova, T. O. SA0006 Chesler, N. SU0072 Cheston, E. SU0043 Cheung, A. MO0416 Cheung, A. M. MO0040, MO0177, MO0331, MO0350, SA0420, SU0338, SU0452 Cheung, C. MO0198, SU0376 Chevalier, J. FR0062 Chevalley, T. MO0380, SA0393 Chiang, M. 1117, FR0211, SA0104 Chiba, K. 1157 Childress, P. SU0260 Chilibeck, P. MO0008, SU0015 Chim, S. SA0207, SA0297 Chimge, N. FR0133, FR0135, MO0137, SA0133, SA0135 Chin, A. SA0373, SU0363 Chin, E. SA0216 Chines, A. A. 1133, SU0441 Chini, B. SU0251 Chintalacharuvu, S. MO0147 Chirgwin, J. M. FR0137, MO0135, SA0134, SU0137 Chitteti, B. Reddy SU0304 Chivu, L. SA0422 Cho, D. MO0406 Cho, H. MO0201 Cho, J. MO0201 Cho, N. SA0376 Cho, S. 1075, SA0139, SA0269, SU0296 Cho, Y. SU0201, SU0366 Chode, S. 1164 Choh, A. MO0195, SA0342, SA0379 Choi, B. SA0374, SU0196 Author Index

Author Index

Clay, R. MO0429 Clemens, T. L. 1001, 1167 Clement, J. SA0057 Clemmons, D. 1196, MO0222 Clezardin, P. 1234 Cliffe, J. MO0358 Climer, L. 1209 Clines, G. A. FR0137, FR0191, MO0144 Clines, K. FR0191, SA0191 Cloonan, Y. 1019 Cloutier, A. 1069, FR0025, SU0076 Coates, A. SU0458 Cobitz, A. 1211, SA0400, SU0046 Coen, M. SA0015 Coetzee, G. MO0136 Coetzee, S. SA0133 Coffin, D. 1029 Cohen, A. 1132, 1200, 1202, FR0415, MO0391, SA0176, SA0415, SU0414, SU0430 Cohen, D. 1092, SU0328 Cohen-Solal, M. 1245, SA0403 Cohn, D. 1083 Coimbra, L. MO0228, MO0274 Cointry, G. SU0078 Colaianni, G. SU0251 Colbert, R. SU0295 Colby, J. FR0312 Cole, S. 1144 Colin, E. SA0277 Collet, C. MO0189, SU0188 Collette, N. FR0208, MO0157 Collin-Osdoby, P. A. 1015 Collins, D. SU0157 Collins, F. MO0281 Collins, M. T. MO0191, SA0031, SA0122, SU0123 Colmenares, A. MO0360 Colnot, C. MO0223 Colombel, P. 1128 Colon, I. MO0176, SU0371 Colon-Emeric, C. SA0440 Colon-Emeric, C. S. 1247, SU0385 Colt, E. SU0327 Colucci, S. SA0149 Comaneanu, M. Raluca MO0392 Combalia, A. MO0232 Compston, J. E. 1024, 1058, FR0377, MO0369, MO0377, SA0377 Conaway, H. H. MO0275 Condon, K. 1035, 1067, SU0234 Conigrave, A. D. MO0474, SU0478 Conklin, B. 1183, MO0241 Conley, P. SA0303 Conlon, C. FR0025 Conroy, R. SA0018 Cons Molina, F. MO0360 Consortium, G. SU0198 Convente, M. SU0095 Conway, S. SA0222 Cooper, A. SA0351 Cooper, C. 1024, MO0369, MO0377, SA0358, SA0377, SU0180 Cooper, D. Michael Lane SA0057, SU0073 321

Index

Choi, H. FR0253, FR0392, SA0253, SA0269, SA0376, SA0380, SA0390, SA0392, SU0240, SU0249, SU0296, SU0379 Choi, J. MO0087, MO0236, MO0418, SA0345 Choi, S. MO0418, SA0269, SU0209 Choi, W. H. MO0379 Choi, Y. MO0443, SU0386 Chokalingam, K. SA0270 Chong, W. H. SA0031, SA0122 Choudhary, S. MO0400 Choudhry, K. SU0018 Chouinard, L. MO0018, SU0047, SU0083 Chrisman, C. SU0453 Christakos, S. SA0488, SU0487, SU0489 Christen, W. SU0448 Christensen, A. SA0150 Christensen, L. MO0441, SA0240, SA0445 Christiansen, B. A. SU0079 Christiansen, C. 1036, SA0298, SA0358 Christiansen, P. SA0169 Christie, C. SU0123 Christie, J. SA0404 Christopherson, K. MO0106 Christov, M. SU0484 Chu, V. FR0260, SA0260, SU0267 Chu, Y. SU0197, SU0241 Chubb, R. FR0267 Chumlea, C. SA0342 Chumlea, W. SA0052 Chun, R. F. MO0484, SU0495 Chung, C. MO0336 Chung, D. MO0406 Chung, H. SU0424 Chung, J. FR0191, MO0406, SA0104 Chung, L. 1230 Chung, M. MO0406 Chung, P. SU0144, SU0282 Chung, U. 1009, 1011, 1151 Chung, Y. SA0395, SA0406, SU0196, SU0386, SU0424 Chutkan, N. MO0258, SA0001, SA0286 Chyu, M. SA0470 Ciancaglini, P. MO0081, MO0102, SU0109 Cianferotti, L. SA0172 Cicek, M. 1121, FR0466, MO0202 Cicuttini, F. SA0481, SU0341 Cinar, Y. MO0387 Cipriani, C. MO0372, SA0008 Cisari, C. SU0416 Ciuffi, S. MO0268 Civitelli, R. 1115, 1148, 1222, 1235, 1256, MO0003, SA0259 Clafshenkel, W. SA0220 Clapp, D. SA0222 Clark, A. 1159 Clark, E. M. 1032 Clark, P. MO0360 Clarke Anderson, H. SA0144 Clarke, B. MO0016 Clarke, B. L. MO0170, SA0170 Clarke, N. SU0484 Clarke, S. SA0399, SU0399

Cooper, J. SA0351 Cooper, M. Stuart SA0443, SA0480 Cope, R. SA0335 Copes, L. E. SA0076 Coppin, C. 1070 Corey, P. MO0350 Cormier, C. MO0034, SA0167 Cornish, J. MO0156, MO0211, SA0100, SA0105 Corpe, R. SA0001 Corradini, C. SU0322 Corry, P. FR0410, SA0410 Corselli, M. SA0104 Cosman, F. 1132, 1248, MO0413, MO0424, SU0062, SU0428 Costa, A. G. MO0172 Costa, C. Cabral 1072, MO0270 Costa, J. L. MO0211, SA0100 Costa, R. MO0465 Costa-Guda, J. SU0172 Costelloe, A. SA0184 Costilla, S. SU0349 Couch, R. FR0030, SA0019 Coudert, A. SU0188 Cournoyer, S. 1131 Courteix, D. MO0076, SA0014, SA0077, SU0023 Covarrubias, K. FR0088 Cox, K. 1120, MO0200 Cox, M. Karen SA0110 Cox, R. SA0045 Coxam, V. MO0002, SA0458, SU0294 Coxon, F. SU0272 Craig, T. A. SU0091 Cram, P. MO0432 Crandall, C. J. 1093, 1094, MO0039, SA0350 Crawford, K. FR0291, SA0291 Crawford, S. 1083 Cremasco, V. SA0283 Cremers, S. MO0172, MO0176, MO0391, SA0173, SU0167 Cres, G. MO0273 Crilly, R. G. MO0453 Crimeen-Irwin, B. 1257, SA0230 Crimi, A. MO0041 Crisostomo, T. MO0166 Cristopoulos, A. SU0478 Critchlow, C. MO0435, SA0352 Croce, C. M. 1217, SA0236 Croft, C. SU0393 Croke, M. MO0295 Crone, E. MO0398 Crosby, D. SU0331 Crotti, T. N. MO0283 Croucher, P. I. SA0045 Cui, C. SA0261 Cui, Q. FR0268, SA0143 Cui, R. MO0179, MO0450 Cui, Y. 1073, SU0312 Culbert, A. L. SU0095 Culbertson, C. MO0121, SU0255 Culiat, C. FR0211 Cullen, C. SU0019 322

Cullen, D. M. SA0060, SA0234, SU0311 Cuming, M. 1032 Cummings, E. FR0030, SA0019 Cummings, S. 1036, 1065 Cummings, S. R. 1023, 1063, 1084, 1212, 1241, 1242, 1248, 1263, FR0411, MO0349, SU0422, SU0428, SU0448 Cunningham, D. MO0149, MO0153, MO0227, SA0226 Cunningham, M. MO0461 Cupples, A. SA0365, SA0366, SU0376 Cupples, L. 1084, 1165, FR0347, FR0383, SU0367 Curci, P. SA0149 Curhan, G. MO0164 Curran, J. MO0195 Curtis, J. SA0372 Curtis, J. R. 1246, 1247, FR0325, FR0433, FR0439, MO0419, MO0430, MO0439, MO0452, SA0356, SA0433, SA0434, SA0439, SA0441, SU0326, SU0387, SU0427, SU0443 Cusano, N. E. 1097, SA0173, SU0167 Cuscito, C. SU0251 Cusick, T. E. FR0473, SA0473 Czekajlo, A. SU0343 Czernik, P. 1227 Czerwinski, E. 1065, MO0442 Czerwinski, S. 1144, FR0367, MO0195, SA0052, SA0342, SA0379 Czymmek, K. SA0317

D De´palle, B. Dı´az, S. Dı´az-Curiel, M. Dı´ez-Pe´rez, A. D’agostino, J. D’amelio, P. D’amico, L. D’angelo, M. D’haese, P. D’souza, S. Da Silva, L. Dadsetan, M. Daft, P. Glenn Dagda, R. Dahia, C. Dahl, R. Dai, K. Dai, R. Dai, W. Dai, Z. Daizadeh, N. Daley, E. Dall’ara, E. Dallas, M. Dallas, S. L. Daly, R. M. Damager, I. Damore, M. Damron, T. A.

1234 MO0196 SU0462 SA0447 FR0013 SU0134 SU0134 SA0113, SU0174 SU0144 SA0156 SU0278 MO0103 MO0155 SA0470 SA0091 SA0186 MO0301 MO0010 SU0317 MO0010 1063, 1065 MO0111 SU0035, SU0056 1068, 1237 SA0111, SU0114 1166 SA0240 MO0248 MO0132, SU0145 Author Index

Danielson, M. E.

Author Index

Deguire, J. MO0110 Dehghan, A. SA0368 Del Fattore, A. 1028, SU0216 Del Fiacco, R. MO0372 Del Rio, L. MO0056 Dela Cruz, A. MO0251 Delaisse, J. 1170, 1173, SA0271, SU0401 Delalandre, A. FR0233 Delaurier, A. SA0098 Delepine, M. SA0198 Delgado-Calle, J. MO0224 Delissen, O. SA0348 Dell’elce, S. MO0340, SU0016 Dell’endice, S. SU0251 Dell, R. SA0354 Deloose, A. 1209, SU0128 Delosh, R. SU0152 Delzell, E. 1246, 1247, FR0433, MO0419, MO0430, MO0439, MO0452, SA0441, SU0326, SU0387, SU0427 Demambro, V. E. 1034, MO0222 Demay, M. 1112 Demer, L. L. 1226, MO0184, SU0183 Demerath, E. SA0379 Demissie, S. 1165, FR0383, SA0365, SU0036, SU0376 Dempster, D. 1203, SU0123 Dempster, D. W. 1200, 1202, MO0061, MO0391, MO0413, SA0415, SU0062, SU0414 Denes, A. SU0392 Deng, D. SU0142 Deng, F. 1174 Deng, H. 1086, 1174, MO0365, SA0289, SA0295, SA0303 Deng, L. MO0235, SA0304 Denham, C. SA0141 Denker, A. FR0453 Dennison, E. M. MO0377 Depalle, B. FR0062, SU0051 Descotes, F. 1234 Deselm, C. FR0299, SA0299 Deshpande, C. MO0248 Deshpande, S. SU0155 Despars, G. SA0265 Desvergne, B. 1191 Devaney, J. SA0009 Devidi, M. MO0168 Devine, A. MO0345 Devlin, M. J. FR0025, SA0025 Devogelaer, J. 1070, MO0420 Dharmapatni, K. MO0283 Dhawan, P. SU0487, SU0489 Dhillon, R. Jeet Singh FR0129, SA0129 Dhundale, A. MO0068 Di Benedetto, A. SU0251 Di Fede, G. SU0446 Di Girolamo, G. MO0488 Di Rocco, F. 1018 Di, S. MO0218 Diamant, M. MO0309 Diaz, E. MO0336 Dickinson, M. MO0108 Dickinson, M. E. MO0211 323

Index

1019, 1094, MO0039, SU0336 Danilack, V. MO0063 Danks, J. A. SA0141 Dann, P. 1053, SA0126, SU0126 Daragon, A. MO0437 Darelid, A. 1179 Darling, A. L. SA0370, SU0353 Darling, M. MO0101 Daroszewska, A. 1082 Das De, S. MO0042 Das, A. MO0470 Dasilva, C. FR0453 Dastani, Z. SU0369 Datta, H. K. SA0301, SU0097 Datta, N. SU0254 Datta, T. SU0254 Dauphin, D. 1224 Davelaar, N. SA0277 Davenport, G. SA0351 Davey, L. MO0030 Davicco, M. SA0458 David, V. N. 1073, SU0120 Davidson, H. 1178 Davignon, R. SA0082 Davis, A. R. MO0108, SU0040 Davis, C. 1177, MO0483 Davis, H. SA0134 Davis, J. 1238, SA0040, SA0148 Davis, L. MO0398 Davis, M. SA0399, SU0399 Davison, K. 1260, FR0384, MO0073, SU0350, SU0370 Dawson, B. 1083, MO0100, MO0107, MO0246, SU0081 Dawson-King, J. MO0463 De Asis, K. MO0448 De Benedetti, F. 1028, SU0216 De Bruijne, M. MO0041 De Brum-Fernandes, A. J. SU0275 De Buhr, T. SA0036 De Camilli, P. 1047, SA0296 De Kooter, M. SA0337 De La Dure Molla, m. SA0112 De La Fuente, M. MO0007 De La Houssaye, G. MO0242 De La Piedra, C. SU0462 De Lucia, F. SA0008 De Papp, A. E. SA0354 De Paula, F. MO0167 De Roos, A. MO0309 De Rossi, A. SU0278 De Vernejoul, M. SA0198, SA0403, SU0188 De Vries, T. J. MO0289 Deacon, S. 1135, FR0448, FR0449 Debeer, J. SU0405 Dechow, P. SU0463 Decker, C. FR0283, SA0283 Declerck, Y. SU0235 Decrombrugghe, B. SA0231 Dedoussis, G. SA0358 Deftos, L. J. SA0151, SA0153, SA0313, SU0141

Dieckmann, M. FR0189, SA0189 Diegel, C. 1220 Diehl, m. SA0396 Diener, M. SU0139 Dieudonne´, F. MO0152 Diez, M. MO0196 Diez, R. MO0488, MO0490 Diez-Perez, A. 1024, 1036, FR0385, FR0439, MO0055, MO0131, MO0284, MO0369, MO0377, SA0377, SU0140 Dighe, A. FR0268 Digirolamo, D. 1001, 1167 Dijkstra, S. MO0353 Dilling, D. SU0182 Dimai, H. SU0055 Dimai, H. P. MO0428, SA0424, SU0346 Dinant, G. 1262 Ding, B. 1061 Ding, K. MO0258, SA0286, SU0028 Ding, X. SU0214 Ding, Y. MO0211, MO0235, SU0321 Diniz, E. SA0162 Dinu, S. MO0397 Distelhorst, K. SA0160 Ditullio, M. 1099, SU0166 Ditzel, N. SU0242 Divasta, A. Desrochers SA0027, SU0029 Divieti Pajevic, P. 1037 Dixon, C. SA0171 Dixon, S. FR0252, MO0101, MO0304, SA0273, SU0184 Dlugosz, E. SA0076 Do Carmo, I. MO0390, SU0440 Do, T. FR0411, MO0341, SA0352 Dobnig, H. 1249, FR0414, MO0366, SA0424, SU0055, SU0346 Dobson, J. MO0240 Dodin, S. 1260 Does, M. SA0053 Doetschman, T. 1029 Doganavsargil, B. MO0387 Dogdas, B. MO0037 Doll, J. 1083 Dolovich, L. MO0453 Domae, E. MO0249, SA0238 Domiciano, D. MO0363 Domingues, A. SA0198 Don-Wauchope, A. SU0044 Donahue, H. 1239 Donahue, H. J. FR0223, SU0314 Donahue, L. B. SA0067 Donahue, S. MO0460 Donaldson, M. G. MO0021, SU0021 Donehower, L. 1085 Dong, C. SU0315 Dong, H. MO0239 Dong, Y. MO0483 Donnelly, E. SA0083 Donnelly, T. SA0184 Donneys, A. SU0155 Donor Nephrectomy Outcomes Research (donor) Network, f. SU0121 Dormuth, C. SU0436 324

Dotta, F. SA0394 Doublier, A. SA0451 Doucette, C. 1196, MO0222 Douillard, T. FR0062 Downs, H. SU0404 Dowthwaite, J. N. SU0080 Doyard, M. SU0243 Doyle, N. MO0006, SU0083 Dreilich, D. SU0355 Drexler, C. SU0346 Drezner, M. K. MO0112, MO0319, SA0032 Drissi, H. MO0469 Drozdzowska, B. SU0343 Druchok, C. SU0044 Du, J. MO0336 Duarte, G. SA0050 Dube, G. 1092, SU0328 Dublineau, I. SA0348 Dubreuil, M. MO0232 Ducher, G. MO0076, SU0023 Duclos, M. MO0076, MO0078 Ducy, P. FR0003, FR0209, MO0252, SU0460 Duda, G. 1106 Dudakovic, A. 1152 Dudek, A. SU0153 Dudler, J. MO0162 Dufour, A. B. FR0011, SU0014 Duggan, D. 1020, SU0369 Dumitrache, C. MO0392 Dumoulin, G. MO0181, SU0181 Duncan, C. 1205, SA0217 Duncan, E. L. FR0199, SA0358, SU0158, SU0369 Duncan, R. L. MO0250, SA0317 Dunstan, C. R. 1109, MO0138, MO0139, SA0136, SU0142, SU0232 Duong, L. 1030, MO0037, MO0469, MO0472, SA0473, SU0472 Dupont-Versteegden, E. MO0015 Dupuis, J. MO0198 Duque, G. MO0267, SA0218, SU0208 Duren, D. 1144, SA0052, SA0342, SA0379 Durham, B. SU0389 Durham, S. SA0355 Durosier, C. SA0393 Durup, D. Tiffany MO0161, SU0494 Dusevich, V. SA0111 Dutra, E. MO0187 Dutton, J. MO0072, MO0465 Duvall, S. SU0342 Duverger, O. FR0243, SA0243 Dwyer, D. 1069, 1080, 1206, 1208, MO0312 Dyer, T. 1144, MO0195 Dyment, N. MO0256

E Eagleton, M. SA0303 Eastell, R. 1135, 1211, 1248, 1252, FR0419, FR0449, MO0038, MO0422, MO0424, SA0336, SA0370, SA0449, SU0058, SU0381, SU0428 Author Index

Author Index

Ensrud, K. E. 1019, 1023, 1058, 1059, 1241, 1242, FR0411, MO0343, MO0349, MO0382, SA0355, SA0359, SU0348, SU0358 Entezami, P. SA0109 Entezari, V. MO0132 Epperly, M. SA0256 Erben, R. G. 1054, MO0399, MO0468, SA0120 Erickson, K. MO0409 Eriksen, E. SU0063 Eriksson, A. E 1021 Eriksson, E. FR0482 Eriksson, J. 1084, FR0199, MO0198, MO0407 Erlandson, M. C. SU0015 Ersek, A. 1159 Esapa, C. SA0045 Esbrit, P. MO0007, SA0308, SU0203 Escott, K. Jane FR0475, SU0047 Eser, P. SU0106 Eskew, J. SA0144 Eskildsen, D. MO0325 Eskin, E. SA0245 Eskridge, T. SU0163 Esliger, A. SA0204, SU0238 Esmonde-White, F. SA0179 Esmonde-White, K. SA0179 Espiritu, R. SU0170 Esposito, T. MO0163 Estrada, K. 1084, 1142, 1165, FR0358, FR0367, SA0358, SU0198, SU0367, SU0372 Evangelou, E. 1084, SA0358 Evangelou, V. SU0367 Evans, B. MO0104 Evans, B. A.J. SA0227 Evans, C. MO0029 Evans, D. SA0196, SA0358, SU0368 Evans, G. FR0466, MO0103, SA0017 Evans, H. MO0415 Everett, E. T. SA0294 Everts, V. MO0289, SA0298, SU0313 Ewing, S. 1212 Eyre, D. MO0107 Ezekowitz, J. 1031 Ezura, Y. 1258, MO0088, MO0237, MO0264, SA0102, SA0114, SA0200, SU0108, SU0156, SU0229, SU0237

F Fa¨ssler, R. SA0102 F. Ferna´ndez, A. MO0224 F. Fraga, M. MO0224 Fabbri, S. MO0268, SA0159 Facchini, A. MO0230 Faccio, R. 1087, SA0148, SA0283 Fagerlund, K. M. SA0142, SA0460, SU0324 Fahlgren, A. MO0070 Fahrleitner-Pammer, A. 1249, FR0414, FR0418, MO0366, MO0428, SA0424, SU0055, SU0346, SU0418 Fairlie, D. SU0300 Fajardo, R. J. MO0381, SA0408 325

Index

Ebeling, P. R. 1166 Eber, M. 1075, SA0109 Ebert, R. MO0001 Ebina, K. 1156, FR0178, SA0178 Ebina, T. SA0426 Economides, A. N. 1120, 1231, FR0095 Econs, M. J. FR0367, MO0116, MO0196, SU0372 Edderkaoui, B. MO0214 Edelman, E. SA0315 Edmonds, K. SA0152, SU0105 Edmonds, S. Westlake MO0432 Edwards, B. J. FR0423, SA0423 Edwards, D. MO0135, SU0137 Edwards, R. 1050 Edwards, W. SA0080 Efstratiadis, A. 1193 Egeland, G. SA0344 Ehlert, K. Marie MO0052 Ehninger, G. 1074 Ehtisham, S. SA0028, SA0478 Einhorn, T. A. 1119 Eiriksdottir, G. SU0356 Eischen, C. MO0269 Eisman, J. A. 1036, 1130, 1259, FR0353, MO0368, MO0378, MO0402, SA0339, SA0358, SA0375, SU0369 Ekker, S. SU0091 El Kettani, S. SA0167 El-Hoss, J. FR0157 Elalieh, H. FR0214, SU0071 Eldabaje, R. MO0381 Eleanor, H. MO0089 Elefteriou, F. FR0132, MO0089, SA0132 Eleniste, P. 1043, FR0307, SA0307 Elford, C. MO0104 Elford, M. SA0227 Elias, P. MO0167 Eliers, P. 1142 Elks, C. SU0372 Elliot, G. FR0095 Elliot-Gibson, V. SA0436 Ellis, K. SU0018 Ellman, R. 1069, SU0076 Ellsworth, M. SA0031 Elrefaey, M. MO0258 Elsalanty, M. SA0213 Elson, A. SU0273 Emaus, N. 1130 Emerson, J. SA0170 Endo, K. 1114, SU0150, SU0477 Endo, N. SA0454 Enerback, S. 1227 Engdahl, C. FR0482, MO0479 Engelke, J. MO0454 Engelke, K. 1135, SA0334, SU0033 English, M. FR0095 Englund, M. 1264, MO0364 Enishi, T. MO0225, SU0085 Enjuanes, A. MO0232 Enomoto-Iwamoto, M. 1195, SA0127 Enriquez, R. 1002, MO0233

Falciano, M. MO0372 Falcioni, S. SU0084 Fallon, N. SU0415 Fan, J. 1046, MO0235, MO0239 Fan, K. MO0204 Fan, W. FR0206, SA0206 Fan, Y. MO0441 Fang, Y. FR0366, SA0366 Fanganiello, R. MO0270 Farach-Carson, M. C. SA0317, SU0138 Farahmand, P. FR0192, MO0445, SA0192 Farber, C. R. FR0245, SA0245 Farlay, D. MO0078, SA0451 Farlow, N. 1035 Farnebo, L. SU0394 Farquharson, C. MO0109, MO0185, SA0125, SA0186, SU0092 Farr, J. Nicholas MO0026 Farrell, C. Lancaster MO0489 Farrow, E. G. FR0119, SA0119 Farthing, J. MO0008 Faruqi, A. MO0292 Fatih, N. SU0243 Fatkin, D. MO0267 Fatourechi, V. MO0016 Faugere, M. 1057 Faulkner, B. SU0015 Favarin, B. MO0081 Favus, M. J. SU0161 Fazzalari, N. SA0314, SA0316 Fazzalari, N. L. SA0402 Fechtenbaum, J. SU0329 Feeley, B. SU0077 Feeney, W. SU0426 Fei, Y. 1029, MO0400 Fein, S. MO0409 Feingold, K. 1212 Feinstein, T. SU0124 Feito, M. SU0203 Feldman, S. MO0328, SU0078 Feldstein, A. C. FR0325, FR0354, SA0354 Felsenberg, D. MO0455, SU0381 Fendri, K. SA0247 Feng, H. MO0296, SA0302 Feng, J. SU0463 Feng, J. Q. 1037, 1051, FR0235, MO0112, MO0319, SU0312 Feng, Q. MO0148 Feng, R. SA0155, SU0259 Feng, X. 1188, FR0290, MO0293, SA0272, SA0304 Feng, Y. 1192 Fennoy, I. SA0018 Fenzl, K. MO0428 Fenzl, K. H. SA0424 Ferchak, M. SU0007, SU0382 Ferguson, P. SU0147 Ferguson, S. 1047 Ferira, A. J. MO0482, MO0483, SU0025 Ferna´ndez-Teruel, A. MO0196 Fernanda Gerlach, R. MO0228 Fernandes, G. Jerome MO0466, MO0471 Fernandez De Castro, L. SA0308 326

Fernandez, C. Fernandez, J. Fernandez, S. Ferracini, R. Ferrari, S. Livio

SA0396, SU0344 MO0124 SA0403 SU0134 1191, 1236, MO0380, SA0393, SU0113 Ferretti, J. Luis SU0078 Ferris, D. SU0371 Ferron, M. FR0003, FR0209, MO0252, SA0209 Ferry, B. MO0076 Fica, S. SA0422 Fidler, E. MO0012 Fields, A. FR0391 Figueiredo, C. MO0363, SU0362 Figura, N. MO0393 Filion, M. 1187 Fina Aviles, F. FR0385 Finch, S. L. MO0340, SU0016 Findlay, D. M. 1042 Fine, J. 1059 Finigan, J. SU0381 Fink, H. A. 1019, MO0382, MO0384, SU0348, SU0358 Finkelshtein, E. SU0273 Finkelstein, J. S. 1093, 1101, SU0043 Finnes, T. 1261 Finnila¨, M. Arttu Jalmari SA0108 Fiorito, G. SU0382 Fischer, P. MO0019 Fisher, J. SU0072 Fitch, J. L. MO0082 Fitzgerald, G. FR0439 Fitzgerald, K. SU0331 Fitzpatrick, L. MO0409, SU0046 Fitzpatrick, L. A. 1211, MO0261, SA0400 Flahive, J. MO0369, MO0377, SA0377, SA0444 Fleet, J. C. SA0188, SU0199, SU0469 Fleming, N. MO0269 Flenniken, A. 1016 Flicker, L. SU0009 Flint, J. MO0196 Florea, S. SA0422 Flores, C. SA0298 Flowers, S. SU0239, SU0262 Floyd, D. SA0303 Fluckey, J. MO0149 Flynn, J. SA0221 Focil, A. SA0371 Foer, D. MO0192 Fogelman, I. FR0419, MO0422 Fogle, R. 1124 Folkestad, L. MO0186 Follet, H. 1234, MO0078, SU0051 Fong, T. MO0318, SU0320 Fong-Yee, C. MO0138 Fonseca, F. Santos MO0344, SA0361, SU0345 Fontan, D. SA0162 Fontan, D. Borges MO0487, SU0491 Fontes, J. MO0198 Formicola, D. MO0163 Author Index

Fornari, M. Foroud, T. Forsmo, S. Fortin, A. Fossali, A. Fosser, C. Fossi, C. Foteini, P. Fournier, P. G.

Author Index

Fuchs, I. Fuchs, R. K. Fuehrer, J. Fuerst, T. P. Fujihara, R. Fujii, M. Fujii, S. Fujii, Y. Fujimori, T. Fujino, K. Fujita, T.

MO0468 1104, SU0402 SU0195 1128, 1135, SA0334 MO0278 SA0352 1229, SA0143 MO0417 SU0407 SA0454 MO0117, MO0249, MO0324, MO0327, MO0417 Fujita, Y. SA0472 Fujiwara, S. 1036, 1060 Fujiyama-Nakamura, S. FR0287 Fukada, S. SU0278 Fukai, A. 1009, 1011 Fukasaku, T. SA0016 Fukuda, K. MO0159 Fukuda, T. 1149, MO0199, SA0244 Fukumoto, S. MO0117, MO0208, SA0127, SU0100, SU0211 Fukunaga, M. 1201, SA0416, SU0423 Fukushima, H. SU0265 Fuller, K. SU0274 Fulzele, K. 1037, 1051 Fulzele, S. SA0213 Funaba, M. SA0278 Funato, N. MO0247 Fung, E. B. MO0446 Fung, L. SU0362 Funk, J. L. MO0026, MO0133, SU0390 Furuya, Y. MO0221, SU0088 Fusaki, N. MO0159 Futagi, M. SU0211 Fyhrie, D. MO0059 Fynan, E. MO0258

G Go´mez De Tejada, M. SA0340 Gu¨erri, R. FR0385, MO0284 Gabet, Y. SU0235 Gabriel, D. SU0063 Gabriel, S. MO0354 Gabusi, E. MO0230 Gacad, M. MO0153 Gadasi, H. SU0468 Gaddy, D. 1181, MO0015 Gafni, R. I. MO0191, SA0031, SA0122, SU0123 Gagnon, B. 1100 Gagnon, D. MO0063 Gagnon, E. MO0189 Gajic-Veljanoski, O. SU0452 Galdes, K. SA0081 Galich, A. SA0396 Galior, K. SU0074 Gallacher, S. J. SA0351, SU0426 Gallagher, A. 1139 Gallagher, A. P. SA0351, SU0426 Gallagher, J. 1133 Gallagher, J. A. SU0107 327

Index

MO0490 FR0367, MO0196 FR0369, SA0369, SU0370 1187 SU0447 MO0061 SA0159 MO0122 FR0137, MO0135, SA0137, SU0137 Fowler, T. W. 1192, MO0015 Fowlkes, J. L. SU0146 Fox, C. FR0347, SA0171, SU0457 Fox, J. MO0173 Fradet, A. 1234 Frame, H. MO0328 Frampton, C. SU0330 Franceschelli, F. SA0159 Franceschi, R. FR0074, MO0244 Franceschi, R. T. MO0231, MO0239, SA0085 Franci, B. MO0337 Franci, M. MO0393, SA0394 Francisconi, C. MO0203 Franco, A. FR0250 Franco, C. SA0225 Frandsen, E. MO0161 Franek, E. 1062 Frangi, A. MO0056 Frank, A. William MO0008 Frank, R. MO0106 Frankel, L. SA0436 Fraser, L. SU0380 Fraser, M. MO0361 Fraser, W. MO0072, MO0465, SA0039, SU0075, SU0158, SU0165, SU0389 Fraser, W. D. SA0457, SU0022 Frassica, F. 1193 Fratzl, P. SU0035 Fratzl-Zelman, N. MO0158, MO0178 Frazier, W. SA0295 Frederick, D. SA0224 Fredman, L. MO0349 Freemont, A. MO0456 Fremont, D. SA0279 Frenkel, B. MO0136, MO0137, SA0133, SA0135, SU0235 Fretz, J. A. MO0259 Freund, B. SU0003 Frey, S. MO0001 Frick, K. K. MO0121 Friederich, N. SA0425 Friedman, S. SU0398 Friesel, R. SU0236 Friess, D. SA0354 Frisch, B. J. MO0146 Fritzemeier, K. MO0468 Fromigue´, O. MO0152 Frost, M. L. FR0419, MO0422, SA0419 Frost, S. A. FR0353 Frye, J. SU0390 Fu, H. 1191 Fu, Q. MO0235, SA0229

Gallagher, K. SU0155 Gallant, M. A. MO0045, SU0234 Galli, C. 1050, 1067 Galli, G. MO0226, MO0268 Gallo, L. MO0436, SU0432 Gallo, S. 1140 Galson, D. FR0163, FR0165, SA0156 Galson, D. L. 1046 Gamble, G. MO0156 Gamer, L. 1120 Gamsjaeger, S. MO0411, SU0035, SU0099 Gan, C. SA0314, SA0316 Ganda, K. SA0443 Gangadharan, V. MO0250 Gannon, F. SU0081 Gannon, F. H. 1085, MO0108, SU0040 Ganss, B. SA0469 Ganzer, D. MO0130 Gao, B. FR0095, SA0095 Gao, T. MO0112 Gao, X. MO0218 Garcı´a, J. SA0317 Garcı´a-Fontana, B. FR0407 Garcı´a-Manrique, M. SU0420 Garcı´a-Martı´n, A. FR0407, SA0407, SU0332 Garcı´a-Renedo, R. MO0224 Garcı´a-Salcedo, J. FR0407 Garceau, R. MO0173 Garcia De Durango, C. SA0308 Garcia, M. 1084, SU0450 Garcia-Giralt, N. MO0284 Gardella, T. J. SA0124 Gardiner, E. M. SU0070, SU0228 Gardner, M. SU0457 Garfinkel, A. SU0183 Garg, A. SU0121 Gariepy, C. MO0446 Garimella, R. SA0144 Garland, T. SA0076 Garlet, G. MO0203 Garnero, P. 1212, MO0320, SU0113 Garrett, L. FR0095 Garrigos, L. MO0131, SU0140 Garrity, M. SA0171 Garshick, E. MO0063 Gartland, A. MO0404 Gary, L. MO0452 Gasser, J. SU0063 Gaur, T. FR0312, SA0312 Gautvik, K. M. SU0097 Gautvik, V. SU0097 Gawalt, E. SA0220 Ge, C. FR0074, MO0239, MO0244 Gebhardt, M. MO0132 Gedeborg, R. 1243 Gee, A. 1127, MO0333 Gefos Consortia, f. SA0358 Gehlbach, S. H. 1024, FR0439, MO0369, MO0377, SA0444 Gelhbach, S. SA0377 Geller, M. 1061, SU0455 Gen, H. MO0427 Genant, H. MO0010 328

Genant, H. K. Genaro, P. Gendron, R. Geng, S. Geng, Y. Gennari, L.

1128, 1135, SA0334, SA0365 MO0004 SA0050 SU0268 MO0184 MO0163, MO0337, MO0393, SA0394 Gentile, M. MO0469, SU0472 Geoffroy, V. 1255, MO0242 Georgy, S. MO0210 Gerard-O’riley, R. SU0260 Gerbaix, M. SA0014, SA0077 Gerdhem, P. FR0327, MO0367, SA0363 Gerlach, R. SU0466 Gerstenfeld, L. C. 1119, MO0082, SA0241 Getty, P. SA0154 Geusens, P. 1262, SA0337 Ghasem-Zadeh, A. 1129, MO0014, MO0334, SU0334 Ghergic, D. Lucia MO0392 Ghosh Choudhury, G. SU0133 Ghosh, S. SU0288 Ghosh-Choudhury, N. SU0133 Ghosh-Choudhury, T. SU0133 Gianfrancesco, F. MO0163 Giangregorio, L. M. 1091, MO0040, MO0351, MO0453, SU0405 Gianoudis, J. 1166 Gibbs, R. 1083 Gifre, L. FR0066, SA0066 Gignac, M. SA0436 Gilbert, E. SA0351 Gilbert, L. MO0243, MO0480 Gilchrist, N. FR0446 Gilchrist, N. L. FR0453, SA0323, SU0330 Gilligan, J. SU0445 Gilligan, J. P. 1134 Gilmour, P. FR0475, SA0475 Gilsanz, V. 1143 Giner, M. SU0397 Gineyts, E. MO0078, MO0320, MO0403, MO0464 Ginter, T. SU0342 Ginther, J. P. SA0455 Giovanna Gandolfi, M. SU0259 Giroux, S. FR0367 Gitanjali, P. MO0261 Giuliano, A. MO0153 Giunta, J. MO0394 Giusti, A. MO0353 Giusti, F. SA0159 Gjertsson, I. MO0271 Gjesdal, G. SA0386 Glu¨er, C. FR0413, SA0413 Glackin, C. A. MO0140 Glazer, N. SU0367 Gleeson, T. SU0437 Glendenning, P. 1163 Globus, R. K. MO0285, SU0286 Glorieux, F. H. 1083, MO0193, SU0032 Glowacki, J. MO0206, MO0342, SA0256, SU0268, SU0282 Glueer, C. 1036, SA0036, SU0381 Author Index

Author Index

Gourlay, M. L. 1059, 1171 Gourmelon, P. SA0348 Gouveia De Oliveira, A. MO0390, SU0440 Gouveia, C. 1072 Gouveia, C. H. MO0270 Govey, P. SU0314 Gower, B. 1177 Goyal, R. FR0211, MO0151 Grabinski, T. SA0145 Grabowska, U. B. SU0474 Graeff, C. FR0413 Grafe, I. 1083, MO0107 Gram, J. MO0186 Grandclement, E. SU0181 Granero-Molto, F. 1123, 1126, MO0084, SA0202 Grange, C. SU0134 Grano, M. SA0149 Grant, C. SU0170 Grant, R. FR0030 Grant, S. F.A. MO0194 Grassi, F. MO0230 Grataco´s, J. SU0420 Grauer, A. 1061, 1063, 1064, 1065, FR0446, MO0442, SU0439, SU0455 Gravallese, E. M. FR0312, SA0201, SU0234 Gray, A. MO0116 Gray, S. MO0460 Grazette, L. SU0455 Grcevic, D. 1005 Green, D. Elyse SA0046, SU0151, SU0207, SU0264 Greenberg, C. MO0193, SU0032 Greenberger, J. S. SA0256 Greendale, G. A. 1093, 1094, MO0039, SA0350, SU0336 Greene, D. SU0023 Greene, E. 1238, MO0149 Greene-Finestone, L. FR0384 Greenfeld-Barsky, K. SU0468 Greenfield, E. MO0255, SA0154 Greenop, K. SU0009 Greenspan, S. L. 1024, MO0142, MO0369, MO0377, SA0377, SU0007, SU0382 Greenwood, T. SU0091 Greep, N. C. MO0153 Greeves, J. MO0072, MO0465, SA0039, SU0075 Gregoire, B. SU0053 Gregory, J. MO0314 Gregory, J. Susan MO0031 Gregory, P. SA0227 Gregson, C. L. MO0160, SU0158 Gregson, R. SA0103 Grewal, R. SU0017 Grey, A. MO0156, SA0100, SU0422 Grider, A. SU0028 Griffin, A. 1111 Grimes, H. SA0156 Grimes, S. 1158 Grimston, S. K. 1115, 1235, MO0003 Grinberg, D. MO0284 Grisanti, M. 1208 329

Index

Gluhak-Heinrich, J. 1073, SU0312 Go, M. SU0366 Gochberg, D. SA0053 Goda, S. MO0249, SA0238 Godfrey, D. MO0197 Goehrig, D. 1234 Goellner, J. 1189 Goetsch, C. MO0401 Goettsch, C. 1207, FR0255, SA0185 Goetz, M. FR0466 Goh, J. MO0042 Gohda, J. SU0305 Going, S. MO0026 Gold, D. T. SA0456, SU0439 Goldberg, H. A. MO0304 Goldberg, L. 1086 Goldman, H. M. SA0050 Goldring, S. R. SU0210 Goldsmith, M. SU0103 Goldstein, S. MO0032, SU0254 Goldstein, S. A. FR0074, MO0111, MO0229, MO0231, SA0081, SU0102, SU0155 Goli, V. MO0435 Goltzman, D. 1052, 1055, 1084, 1251, FR0384, SA0358, SU0118, SU0121, SU0122, SU0173, SU0350, SU0369 Gomes, R. SU0143 Gomez Acotto, C. SU0164 Gomez, A. SU0349 Gomez, C. SU0349 Gomez-Marin, O. SA0037 Gonc¸alves, A. MO0390, SU0440 Gong, B. SU0155 Gong, H. SU0377 Gonnelli, S. MO0337 Gonza´lez Macı´as, J. 1160 Gonza´lez, J. SU0420 Gonza´lez, P. SA0101 Gonza´lez, R. SU0384 Gonza´lez-Cantalapiedra, A. SA0101 Gonza´lez-Martı´n, M. 1160 Gonza´lez-Padilla, E. SA0340 Gonzalez, D. SU0344 Goodpaster, B. MO0347, SA0388 Gopalakrishnan, R. SU0153, SU0307 Gorai, I. SU0459 Gordish-Dressman, H. SA0009 Gordon, C. L. MO0011, MO0040, MO0347, SA0357, SA0388 Gordon, C. M. SA0027, SU0029 Gordon, J. A.R. 1217, FR0242, MO0240, SA0242 Gordon, K. SA0338 Gori, F. 1112 Gorochow, L. MO0079 Gorski, J. P. SU0005 Gortazar, A. SA0308 Goseki-Sone, M. MO0190, SA0320 Gosman, J. H. MO0020 Gossiel, F. 1252, SA0370 Gotfredsen, K. SA0240 Gottesman, G. SU0185 Gould, V. 1032

Grisanti, M. S. Grize, L. Grodzki, A. Grol, M. W. Gronowicz, G. Gross, T. Gross, T. S. Grover, M. Grubb, A. Grubbe, M. Gruber, E. Gruenwald, K. Grunda, J. Gruodyte, R. Grygo, S. Grynpas, M. Grynpas, M. D.

1206 SA0425 SU0374 FR0252, MO0101, SA0252 SA0221, SU0238 SU0333 SA0007, SU0070, SU0228 MO0107, SU0018 MO0271 MO0459 SU0313 1181 MO0144 SU0479 1121, FR0466, MO0202 SU0147 1182, FR0063, MO0054, MO0251 Grzeszczak, W. SU0343 Gu, F. SU0285 Gu, J. SU0413 Gu, S. FR0073 Gu, T. SU0101 Guan˜abens, N. FR0066 Guadalix, S. MO0024 Guan, J. MO0229 Guan, M. 1025, SA0467, SU0002, SU0045, SU0317 Guan, Y. 1046 Guanabens, N. MO0232, SA0459 Gudnason, V. MO0408 Gudnason, V. G. 1084, SA0358, SA0382, SU0356 Guede, D. SA0101, SU0462 Guelcher, S. A. SA0140 Guenther, A. SA0281 Guenther, K. 1207 Guerri Fernandez, R. MO0055 Gugala, Z. SU0040 Gugatschka, M. MO0366 Guggenbuhl, P. SU0243 Guggina, P. MO0369 Guicheux, J. J. SU0294 Guillet, C. SA0014, SA0077 Guilluy, C. FR0072 Guise, T. A. 1013, FR0137, MO0133, SA0134, SA0222, SU0316 Gunaratnam, K. SA0218 Gundberg, C. M. 1103, 1212 Gunning, K. SA0372 Gunraj, N. SU0436 Guntur, A. R. 1017, 1213 Guo, B. 1026, 1027, FR0079, SA0471, SU0217 Guo, J. FR0131, MO0126 Guo, R. SA0484 Guo, X. 1205, MO0083, SU0230, SU0414 Guo, X. Edward 1107, 1132, MO0044, SA0048, SA0176, SU0315, SU0460 Guo, Y. MO0365 Gupta, G. K. MO0486, SA0486 Gupta, H. SA0045 Gupta, N. MO0265 330

Gupta, S. Gurski, L. Gurzawska, K. Gut, J. Guth-Gundel, S. Gutierrez, S.

SA0146 SU0200 SA0240 MO0028 MO0463 SA0231

H Ha˚kansson, H. SA0108 Ha, H. MO0302 Ha, Y. MO0356, SU0361, SU0434 Haase, M. 1074 Habauzit, V. SA0450 Habermann, I. 1074 Hackfort, B. SA0234, SU0311 Haddock-Suarez, L. SU0384 Hadji, P. MO0431, SA0437 Hadjiargyrou, M. MO0099, SU0117 Haduong, J. SU0235 Hagihara, T. MO0105 Hagino, H. 1201 Hahn, M. 1108 Hahn, N. MO0135 Haile, S. MO0006 Haines, Pnp, D. MO0446 Hajibeigi, A. SA0485 Hajjawi, M. SU0222 Hakami, T. SA0404 Hakeda, Y. SU0291 Halade, G. MO0466 Hald, J. MO0186 Haley, S. MO0029, SU0030 Hall, J. MO0442 Hall, P. FR0475 Halleen, J. M. SA0142, SA0460, SU0042, SU0324 Haller, I. V. MO0454 Halleux, C. MO0307 Halloran, B. P. SA0260, SU0267 Halstead, L. R. SA0160 Halton, J. FR0030 Hamang, M. SU0130 Hamann, C. 1207 Hamaya, E. SA0442 Hambli, R. MO0033, MO0062, SA0042 Hamdy, N. A. T. 1102, MO0309, MO0353, SU0191 Hamdy, R. C. MO0205 Hameed, O. 1230 Hamersma, H. SU0191 Hamidi, M. S. MO0350 Hamidi, Z. MO0338 Hamilton, A. SU0389 Hamilton, C. J. MO0073 Hammett-Stabler, C. 1171 Hammond, D. SA0075 Hammond, J. SU0184 Hampson, N. SA0050 Hamrick, M. W. MO0258, SA0001, SA0213, SA0286 Han, B. SU0152, SU0366 Han, C. MO0248 Author Index

Han, J. Han, L.

Author Index

Hata, Y. Hatch, N. E. Hattori, T. Haubourg, M. Haudenschild, D. Haug, E. Hauge, E. Hauge, E. M. Haughey, B. Haugshøj, K. Hausman, B. Hausman, D. Havill, L. Havrdova, E. Hawker, G. Hawkes, W. Hawkins, F. G. Hawse, J. R.

SU0335 MO0260 FR0090 SU0448 SU0079 SU0125 MO0125 1170, SU0041 SA0123 SA0240 MO0255 MO0482, MO0483 SU0048 SA0326 SA0436 1096, MO0374 MO0024 1121, FR0466, MO0202, SA0466 Haxaire, C. 1255 Hay, E. 1214, 1255, SU0476 Hayakawa, N. MO0324, SA0324, SU0119 Hayashi, M. SA0464, SU0131 Hayashi, Y. 1183, SU0283 Hayashida, C. SU0291 Hayata, T. 1258, MO0088, MO0237, MO0264, SA0102, SA0114, SA0200, SU0108, SU0156, SU0237 Hayden, C. SU0342 Hayek, J. SA0344 Hayes, C. W. SA0335 Haynes, D. MO0283, SA0181, SU0300 Hays, M. 1218 Hazell, T. J. MO0340, SU0016 He, F. 1026, 1027, FR0079 He, J. SA0203 He, L. SU0266 He, Q. SU0236 He, X. FR0004, SA0203 He, Y. 1013, 1026, 1186, FR0079, SA0079, SA0222, SA0471, SU0464 Head, R. SA0045 Healy, M. SU0415 Heard, A. SU0330 Hedge, A. SU0120 Heegaard, A. MO0161, SU0494 Heeren, J. SU0003 Hefferan, T. MO0103, MO0405 Heggeness, M. SU0081 Heggeness, M. H. SU0040 Heickendorff, L. SA0169 Heinegard, D. 1089 Heinonen, A. O. MO0047 Helfrich, M. H. 1081, MO0314, SU0272 Heller, E. 1086, SA0303 Helmandollar, K. SU0030 Helms, J. FR0078 Hembree, K. SA0399 Hemingway, F. SA0282 Hemmi, H. MO0237, SU0156 Hen, R. 1205 Henderson, J. 1182, MO0475 Hendrix, B. 1181 331

Index

SU0209 1110, 1168, 1189, FR0002, MO0476, SU0470 Han, M. MO0236 Han, S. SA0288, SU0209, SU0277 Han, X. MO0319, SU0463 Hanaoka, K. MO0466 Hanaoka, N. SU0150 Hanaoka, T. SU0396 Haney, E. M. MO0343, SA0173, SU0167 Hangartner, T. N. SU0066 Hankenson, K. D. 1218, MO0194 Hanks, L. MO0022 Hanks, L. Jane MO0124 Hanley, D. 1064, 1203 Hanley, D. Arthur 1136, FR0384, MO0331, SU0037, SU0050, SU0173 Hanlon, M. SU0260 Hannah, K. SA0057 Hannan, M. T. FR0011, MO0352, SU0014 Hannon, R. A. SA0370 Hannouche, D. SA0198 Hannukainen, J. 1216 Hans, D. 1036, MO0162 Hansen, K. E. MO0398 Hansen, S. MO0125, MO0186 Hansma, P. K. MO0055 Hansson, P. MO0357 Hanyu, R. SA0114 Harada, A. MO0097 Harada, S. SA0477 Harada, T. 1229, SA0143, SU0090 Haraikawa, M. MO0190, SA0320 Harbers, E. SU0485 Hardy, R. SA0480 Hare, D. MO0014 Hariman, A. SU0359 Harland, R. FR0208, SA0208 Harmon, B. SA0009 Harrington, T. MO0452 Harris, M. A. 1073, MO0308, SU0312 Harris, S. E. 1073, MO0308, SA0408, SU0312 Harris, T. 1084, 1212, MO0408, SA0382, SU0008, SU0356, SU0367, SU0450 Harrison, S. L. MO0384, SA0359 Harrison, T. SU0439 Hart, K. SU0353 Hartman, E. MO0030 Hartmann, D. MO0078 Harvey, E. MO0475 Haschka, J. MO0397, SU0418 Hasegawa, K. SU0202 Hasegawa, M. MO0159 Hasegawa, T. MO0315 Hashimoto, J. 1156, SA0178 Hashimoto, Y. FR0044, FR0448, SA0180, SU0473 Haslam, J. SA0335 Hassan, B. 1251 Hassan, M. Q. 1217, SA0242 Hastings, R. SA0151, SA0153 Hata, K. 1155

Hendy, G. N. Henning, P. Henriksen, K.

SU0233, SU0256 MO0271 MO0297, SA0117, SA0298, SU0299, SU0321 Henry, M. SA0481, SU0012, SU0341 Heppe, D. 1142 Herberg, S. FR0213, SA0213 Herbert, B. SU0260 Herlin, M. SA0108 Herman, B. SA0408 Hermann, A. SU0444 Hermosilla, E. FR0385 Herna´ndez, D. SA0340 Herna´ndez, L. SU0384 Hernadez, P. SA0275 Hernandez, C. J. MO0052 Hernon, K. MO0119 Heroux, A. SU0359 Herrera, B. Schneider MO0274 Herrera, L. 1142 Herrick, J. MO0103 Herrmann, M. MO0489 Herskovitz, R. SU0194 Herz, J. SA0189 Herzog, H. 1002, MO0233 Hesse, E. 1145 Hewison, M. MO0480, MO0484, SU0495 Heymsfield, S. MO0396 Heyny, A. MO0399 Hiasa, M. 1229, SA0143, SU0283 Hibbs, M. A. SU0101 Hicks, D. 1233 Hicks, G. SU0008 Higashiuchi, Y. SU0412 Higuchi, M. MO0389 Hikata, T. 1009 Hildreth, B. Eason MO0119 Hill, K. 1166, SU0009 Hill, K. M. MO0023, MO0045, MO0482, SA0175, SU0025 Hill, W. MO0258, SA0213 Hillegonds, D. J. MO0157 Hiller, J. SA0045 Hillier, T. 1058 Hillier, T. A. 1023, 1242, 1263, MO0349, SU0358 Hillman, D. SA0001 Hillman, E. SU0315 Hinkle, J. MO0099, SU0117 Hinnie, J. SU0426 Hipp, J. MO0108, SU0040 Hirai, H. SU0119 Hirai, T. SU0087 Hirano, F. MO0371 Hirao, M. 1156, SA0178 Hirata, M. 1011, 1151, MO0182, SA0401 Hirbe, A. SA0303 Hiremath, M. FR0126, SA0126 Hirose, J. 1190, MO0282, SU0297 Hirota, K. SU0351 Hirota, T. SU0351 Hiroyuki, A. 1190 Hirsch, B. MO0461 332

Hirschfeldova, K. Hitchcock, C. Hite, K. Hiyama, S. Ho, C. Ho, H. Ho, P. Ho-Pham, L. Hobson, R. Hochberg, M. C.

FR0158 SU0190, SU0370 SU0152 SU0298 SU0214 MO0085, SU0245 1257 SU0373 MO0072, MO0465 1096, 1242, 1263, MO0349, MO0374, SU0358 Hocking, J. 1131 Hocking, L. J. 1081, SA0300, SA0358 Hodgson, S. F. MO0405, SA0017 Hodsman, A. SU0121 Hoehna, Y. 1207 Hoenig, H. SA0373, SU0363, SU0363 Hoey, D. SA0075 Hofbauer, L. C. 1074, 1207, FR0255, MO0401, SA0185 Hofflich, H. Leigh MO0175 Hoffman, E. SA0009 Hoffman, H. 1115 Hoffmann, C. MO0234 Hoffmann, J. SA0225 Hoffmann, M. SA0097 Hoffmann, U. FR0347, FR0383 Hofman, A. 1142, SU0198 Hogan, D. 1119 Hogan, H. A. 1238, MO0149, MO0227, SA0040, SA0226 Hogendoorn, P. SU0144 Hogue, W. MO0015 Hohman, E. MO0467 Hokugo, A. MO0204 Holanda, N. SU0491 Holanda-Miranda, W. MO0167 Holbrook, J. FR0423 Holdsworth, D. MO0101, SU0184 Holick, M. F. SU0029 Holingshead, M. SU0152 Hollenbeak, C. 1092 Holliday, L. S. MO0286 Hollinger, J. O. MO0294 Holloway, A. SU0044 Holmbeck, K. MO0114, SA0116, SU0110 Holmes, C. SA0179 Holton, K. SA0012 Holvik, K. SA0386 Holz, J. SU0245 Holzer, G. 1199 Holzer, L. 1199 Homan, E. MO0107 Homan, E. Paige 1083 Homma, S. 1099, SU0166 Homma, Y. MO0427 Honda, Y. SU0214 Hong Chen, L. 1013 Hong, J. SU0433 Hong, S. MO0379, SU0196 Hong, Y. SA0144, SU0120 Hongo, M. MO0359, MO0444, SU0419 Honkanen, R. MO0375, MO0376 Author Index

Honnerova, M. Hoon, D. Hooper, G. Hooshmand, S. Hooven, F. H.

Author Index

Huang, X. SU0391 Huang, Z. MO0083 Hubbell, Z. Randall MO0020 Huber, A. SA0019 Huber, P. SA0007 Huckabay, S. SU0153 Hue, T. F. MO0408 Huesa, C. MO0109, SA0125 Hufert, K. 1128 Huffman, N. SU0005 Hughes, P. SU0153 Hughes, a. SA0303 Hui, R. SU0458 Hum, D. 1150 Humbert, L. MO0056 Hummel, K. MO0040 Humphrey, M. SU0303 Hung, L. 1026, 1027, SU0217 Huniche, L. SU0444 Hunter, M. MO0258 Huntjens, K. 1262 Hurchla, M. Anne 1086, SA0295, SA0303 Hurd, A. 1104, SU0402 Hurley, M. 1029, MO0400, SA0204, SA0463, SU0238 Huskey, M. SU0193 Hussain, S. FR0312, SA0224 Hussein, A. SA0055 Hussein, K. SA0213 Husseini, A. 1113 Hussey, J. 1139 Hwang, H. SA0251 Hwang, J. SA0243, SU0366 Hwang, S. MO0212, SU0290, SU0379 Hyodo, E. SU0166

I Iaiani, G. Iantomasi, T. Ibrahim, Q. Ichikawa, L. Ichikawa, S. Ichiro, K. Ido, Y. Igarashi, T. Igwe, J. C. Iida, A. Iida, S. Iikuni, N. Iimura, T. Ikeda, K. Ikeda, S. Ikeda, T. Ikeda, Y. Ikegami, S. Ikegawa, S. Ikeo, T. Ikeya, M. Ikramuddin, S. Ikuyo, K. Im, S. Imaeda, T.

MO0372 MO0226 1136 MO0341 MO0116 MO0299 SU0335 SU0293 SA0237 MO0159 SA0472 SA0442 MO0266, SA0320, SU0090 SU0309 MO0128, SA0118 1011, 1151 MO0322 SU0335 SU0366 MO0249, MO0327, SA0238 SU0187 MO0071 SU0366 MO0426 SU0335 333

Index

SU0383 MO0153 SU0330 SU0104, SU0160, SU0413 1024, MO0369, MO0377, SA0377 Horak, M. 1127 Horcajada, M. SA0450 Horch, A. SA0053 Horikawa, A. MO0359 Horn, D. MO0308 Horne, A. MO0156 Horne, W. C. 1003, 1047, 1145, MO0272, SA0274 Horner, J. SU0426 Hornick, M. 1086 Horowitz, M. C. 1034, MO0259 Horrell, C. MO0469, SU0472 Horrocks, B. SA0301 Horst, R. L. 1079 Horva´th, B. MO0180 Horwood, N. J. 1159 Hosaka, Y. 1009 Hose, C. SU0152 Hoshi, K. SA0246 Hoshijima, M. FR0090, SA0090 Hoshino, A. MO0266 Hosoi, T. MO0190, SU0423 Hosomichi, J. MO0077 Hou, Y. FR0088 Hovi, P. MO0407 Howard, D. SA0387 Howat, P. 1163 Hoy, C. L. MO0021, SU0021 Hoylaerts, M. MO0102, SU0109 Hruska, J. 1066 Hsiao, E. SU0187 Hsiao, E. C. 1183, MO0241 Hsieh, S. SA0468 Hsu, B. 1218 Hsu, J. MO0184, SU0439 Hsu, L. FR0284 Hsu, S. SU0245 Hsu, W. 1152 Hsu, Y. 1084, 1165, FR0347, MO0198, SA0347, SA0358, SA0365, SA0366, SU0367, SU0372, SU0376 Hu, H. MO0022 Hu, L. MO0218, SA0417 Hu, M. SU0067, SU0393 Hu, W. FR0291 Hu, X. 1158 Hu, Y. MO0214 Huang, A. MO0463 Huang, C. 1147, 1219 Huang, D. SU0208 Huang, F. SU0391 Huang, J. MO0086 Huang, L. 1222, 1256 Huang, M. 1094, MO0039 Huang, S. 1043, FR0307 Huang, T. SA0468 Huang, W. FR0205, MO0204

Imagita, H. Imai, Y.

SU0396 1007, FR0287, FR0310, FR0483, MO0067, SA0310, SA0483 Imamura, K. MO0091, SU0244 Imaoka, A. MO0105 Imel, E. A. MO0135 Inaba, M. MO0317 Inada, M. FR0147, MO0182, SA0401 Inderjeeth, C. A. 1163 Ing, S. W. MO0373, SU0352 Ingle, J. FR0466 Inglis, D. MO0040 Inloes, J. 1012, 1154 Inose, H. SU0460 Inoue, D. MO0050, SA0065 Inoue, J. SU0305 Inoue, K. 1007, SA0483 Inoue, N. MO0315 Insogna, K. L. 1162, MO0192, MO0258, MO0288, SA0286, SA0306 Intini, G. MO0200 Invernizzi, M. SU0416 Ioannidis, G. MO0453, SA0444, SU0136 Ioannidis, J. 1084, SA0358, SU0367 Ionita, D. SA0422 Irish, J. MO0462 Isaac, J. SA0243 Isaia, G. SU0134 Isaksson, H. FR0182 Isales, C. M. MO0258, SA0001, SA0286, SU0028, SU0266 Ish-Shalom, S. SU0438 Ishani, A. MO0382 Ishida, Y. SA0464 Ishidou, Y. MO0091, SU0244 Ishihara, Y. SU0265, SU0319 Ishii, J. MO0324, SA0280 Ishii, M. FR0285 Ishii, S. 1094, MO0039 Ishijima, M. MO0427 Ishikawa, T. MO0324 Ishikawa, Y. MO0444 Ishimaru, N. SU0283 Ishimi, Y. MO0389 Isidori, A. MO0372 Islam, M. Saiful SA0263 Island, M. SU0243 Islander, U. MO0479 Ismail, A. MO0456 Isse, T. SA0096 Itabashi, A. MO0335 Itakura, Y. MO0417 Ito, A. MO0317 Ito, J. SU0291 Ito, M. 1201, SA0416 Itoh, M. MO0324, SA0324, SU0119 Itoh, S. 1151 Itoman, M. SU0467 Ittrich, H. SU0003 Itzstein, C. SU0272 Iuliano-Burns, S. SU0334 Ivashkiv, L. 1158, SU0289 Ivaska, K. MO0254 334

Ivaska, K. K. MO0407 Iversen, M. SU0437 Ives, R. 1097, MO0172, MO0414 Iwaki, K. SU0396 Iwamoto, J. SA0431, SA0462, SU0465 Iwamoto, M. 1195, SA0127 Iwamoto, T. MO0208, SU0100, SU0211 Iwaniec, U. T. 1004, 1121, SU0204, SU0206 Iwaoki, Y. SU0459 Iwasaki, M. SU0407 Iwata, A. SU0412 Iwata, S. SU0166 Iyer, S. 1110, 1168, FR0002, MO0476, SU0470 Izard, R. M. SA0039, SU0075 Izawa, T. MO0306, SU0283 Izu, Y. SA0114 Izumi, Y. SU0237 Izumo, N. SU0471

J Jørgensen, H. SU0494 Jørgensen, L. 1130 Ju¨rima¨e, J. SU0479 Ju¨rima¨e, T. SU0479 Jackowski, S. A. 1175 Jackson, C. SU0232 Jackson, G. Scott MO0321, MO0477 Jackson, R. MO0373, SA0358 Jackson, R. D. 1020, SU0352, SU0369 Jackuliak, P. MO0329 Jacky, C. 1141 Jacobs, C. R. FR0078, SA0075 Jacobson, J. MO0010 Jacome, C. Eduardo MO0279 Jacques, P. MO0348 Jacques, R. M. MO0424 Jaddoe, V. 1142 Jaehn, K. FR0005, MO0005, SU0001 Jafari, A. SU0242 Jafferji, M. 1217 Jaffre´, C. SU0068 Jaffre, C. SA0402 Jafrelo, L. SA0450 Jahn, R. SA0302 Jakob, F. MO0001 Jalanko, H. FR0182 Jamal, S. A. MO0073, MO0177, SU0175 Jamart, J. MO0420 James, A. 1117, FR0088, FR0211, SA0104, SA0211 James, T. MO0409 Jami, A. MO0212, SU0249 Jamsa, T. J. SA0108 Janckila, A. J. SU0271 Jang, B. FR0392 Jang, E. SA0341, SU0375 Jang, W. SU0240, SU0248 Janic, K. SU0147 Janos, B. 1203 Jarrahy, R. MO0204 Jarvinen, T. L. N. SU0073 Author Index

Author Index

Johnson, R. Johnson, m. Johnston, J. Joiner, D. Jokihaara, J. Jolette, J. Jonason, J. Harrell Jones, A. N. Jones, C. Jones, J. Jones, T. Jonker, J. Jonsson, B. Joo, I. Joo, N. Jorcyk, C. Jordan, C. Jordan, K. Jorgensen, M. Jorgensen, N. Rye

1153 SU0072 1175, SA0051 FR0087, SA0087 SU0073 MO0018 SA0476 MO0398 SA0087, SA0097, SA0480 MO0415 MO0072 MO0309 SA0382 SA0390 SA0374, SU0323 SU0213 MO0146 SU0030 SA0152, SU0105 MO0161, MO0404, MO0457, SA0240, SU0222 Josefson, J. SU0031 Joseph, F. SU0389 Joseph, L. FR0384 Joshi, A. MO0381 Joshi, S. SU0489 Josse, R. 1211 Josse, R. G. 1055, MO0453, SA0420, SU0173, SU0350 Jovic, T. MO0154 Ju, K. MO0213 Juan, T. MO0248 Juarez Camacho, P. SA0134 Judex, S. MO0057, MO0065, MO0068, SA0067, SA0070, SA0076, SU0061 Jueppner, H. MO0126, MO0191, SA0124, SU0318, SU0484 Jukema, J. 1084 Jules, J. 1188, FR0290, MO0293, SA0290 Jung, S. SA0269 Jung, T. SU0196 Jung, Y. SU0277 Jurkovic Mlakar, S. MO0438 Jurvelin, J. MO0339 Jutberger, H. SA0010, SA0378 Juurlink, D. SU0431

K Ka¨ho¨nen, M. Ku¨hne, F. Kacena, M. A. Kaci, N. Kadler, K. Kado, D. M. Kadoya, K. Kagawa, K. Kahan, A. Kahonen, M. Kainberger, F. Kaiser, S. M. Kajantie, E. Kaji, H.

SA0196, SU0020, SU0368 FR0418 1043, SU0304 1018 SA0111 SU0008, SU0358, SU0448 SU0202 1229, SA0143 MO0034, SA0167 1084 SA0043 MO0328, SU0350 MO0407 SU0256 335

Index

Jarvis, J. SU0107 Jastrzebski, S. MO0400 Jaurand, X. SA0451 Javaheri, B. 1068 Javaid, M. K. SU0180 Javed, A. SA0231 Javed, F. SU0327 Jayakar, R. SU0066 Je, S. SA0374, SU0323 Jean, S. 1260, SA0362 Jean-Philippe, S. MO0340, SU0016 Jehan, F. SA0198 Jenkins, M. SA0335 Jensen, E. D. SU0307 Jensen, L. MO0161 Jensen, P. Rosgaard 1170 Jensen, V. Kaiser MO0297, SA0298 Jeon, J. SU0209 Jeong, H. MO0406 Jeong, J. MO0236 Jeong, K. 1086 Jepsen, K. J. SA0050 Jerums, G. MO0014 Jester, P. MO0452 Jewison, D. MO0103, MO0405 Jeyabalan, J. 1215 Ji, A. MO0066 Jia, D. SA0410 Jia, J. 1025, SA0467, SU0002, SU0045, SU0317 Jian, J. SU0391 Jiang, C. 1013 Jiang, J. SU0481 Jiang, J. X. FR0073, MO0308, SA0479, SU0310, SU0317 Jiang, L. 1186, SA0222 Jiang, M. 1085, MO0107, SU0081, SU0093 Jiang, N. SA0474, SU0039 Jiang, Q. MO0301 Jiang, X. 1228, MO0086, MO0256, SA0258, SU0269 Jiang, Y. 1046, 1054, MO0010 Jilka, R. 1110, 1209, MO0476, SU0128, SU0470 Jilka, R. L. 1076 Jimi, E. SA0244 Jin, C. SA0400 Jin, H. 1223 Jin, S. SA0156 Jin, V. SU0285 Jin, Y. MO0406 Jin, Z. SU0166 Joakimsen, R. 1130 Jogeswar, G. MO0212, SU0249 Johannesson, M. MO0196 Johansson, H. 1036, 1091, MO0358, SA0010, SA0328, SA0378, SU0445 Johnsen, S. MO0263 Johnson, J. 1136 Johnson, L. 1231 Johnson, M. SA0213 Johnson, M. L. 1068, 1237, FR0005, MO0005, SU0001

Kajihara, H. Kalajzic, I.

MO0427 1005, 1073, FR0312, MO0086, SA0237 Kalajzic, Z. MO0069 Kalbakji, A. 1187 Kalidindi, S. SA0050 Kalinowski, J. MO0400 Kalkwarf, H. J. 1143 Kallich, J. MO0429, SU0443 Kallikorm, R. SU0013 Kallinen, M. MO0047 Kalra, S. SU0204 Kamada, A. MO0249, MO0327, SA0238 Kamanda-Kosseh, M. 1132, MO0176, SA0176, SU0340 Kamel, S. A. SA0111 Kameo, Y. MO0067 Kamijo, R. SU0090, SU0263, SU0281 Kamimura, M. SU0335 Kamioka, H. MO0067, SA0320, SU0265, SU0319 Kamiya, Y. MO0123 Kammerer, C. M. SA0358, SA0364 Kampfschulte, K. SA0145 Kamusella, P. SU0454 Kanaya, A. 1212 Kanazawa, I. SA0183, SU0233 Kaneko, K. MO0427, SA0068, SA0266, SU0219 Kaneko, M. SA0054 Kaneko, S. MO0077 Kaneshiro, S. 1156 Kang, H. SA0245 Kang, I. SU0240, SU0248 Kang, M. SU0366 Kang, M. M. SA0341, SU0375, SU0424 Kang, N. MO0448 Kang, Y. MO0093, SU0366 Kanis, J. SU0445 Kanis, J. A. 1036, 1091, MO0358, SA0010, SA0328, SA0378 Kannus, P. SU0011 Kanoh, S. SA0096, SA0219 Kantner, I. MO0468 Kantor, S. SA0404 Kao, R. S. FR0309, FR0391, SA0309 Kapiotis, S. MO0397 Kaplan, F. S. SU0095 Kapoor, A. 1122, 1178, MO0214 Kapoor, M. 1150 Kaptoge, S. K. 1084, SA0358 Kapur, R. SU0127 Kar, R. 1017, MO0308, SA0479, SU0310 Karakawa, A. SU0293 Karam, N. FR0250 Karampinos, D. SA0049 Karaplis, A. SU0126 Karaplis, A. C. 1052, SU0118 Karasik, D. 1084, 1165, FR0367, MO0198, SA0358, SA0365, SA0366, SU0367, SU0372, SU0376 Karellis, A. SA0429 Karim, L. SU0059 336

Karimian, E. FR0482 Karin, N. J. SU0314 Karinkanta, S. SU0011 Karjalainen, J. Petri MO0339 Karlamangla, A. MO0039, SA0350, SU0336 Karlamangla, A. S. 1094 Karlsdottir, G. SU0356 Karlsson, M. 1021, 1264, FR0020, MO0364, SA0010, SA0020, SA0378, SU0125 Karmakar, S. SA0201 Karmi, A. 1216 Karpiuk, O. MO0263 Karsch, U. MO0344, SA0361, SU0345 Karsdal, M. A. MO0297, SA0117, SA0298, SU0321 Karsenty, G. FR0003, FR0209, MO0252, SA0114, SU0460 Karunaratne, A. FR0045, SA0045 Karuppaiah, K. MO0305 Kasa-Vubu, J. SA0031 Kasaai, B. MO0205 Kasagi, F. 1060 Kashii, M. SU0407 Kasperk, C. H. SA0432 Kasprzykowski, F. MO0271 Kassai, H. SU0090 Kassem, M. 1045, MO0001, MO0263, MO0277, SA0228, SU0242, SU0250 Kasuga, N. SU0069 Kasukawa, Y. MO0444, SA0426, SU0360, SU0419, SU0475 Katagiri, T. 1120, 1149, MO0199, SA0244, SU0256 Kathiresan, S. FR0383 Kato, H. SA0098, SU0335 Kato, R. MO0427 Kato, S. 1007, FR0287, SA0310, SA0483 Katsaros, E. MO0386 Katz, J. SU0437 Katzenellenbogen, B. SU0470 Katzenellenbogen, J. SU0470 Katzman, W. SU0008 Kaufman, J. 1066 Kaufman, J. J. SU0340 Kavanagh, S. FR0475 Kaw, K. SA0456 Kawabata, K. FR0044, SA0180, SU0473 Kawaguchi, H. 1009, 1011, 1151, MO0385, SA0246, SU0378 Kawai, M. 1034, 1196, 1213, FR0094, MO0316 Kawai, S. SA0248 Kawalilak, C. E. SA0051 Kawamoto, T. SA0096 Kawamoto, Y. 1210 Kawamura, I. MO0091, SU0244 Kawanabe, N. SU0265, SU0319 Kawanami, M. SU0247 Kawasaki, I. SU0351 Kawasaki, M. MO0088, SU0108 Kawatani, M. SA0143 Kawato, T. SU0220 Kawato, Y. 1156 Author Index

Author Index

Kikuchi, W. SU0325 Kikuta, J. FR0285, SA0285 Kilander, L. 1243 Kilbane, M. SA0161 Kilgore, M. L. 1246, 1247, MO0419, MO0439, MO0452, SA0434, SU0326, SU0427 Killinger, Z. MO0329 Kilpadi, K. MO0381 Kilts, T. SU0110 Kim, B. MO0219, SU0296, SU0366, SU0425 Kim, C. MO0175, SU0196 Kim, D. MO0356, MO0379, SU0361, SU0366, SU0434 Kim, E. MO0212, SU0240 Kim, G. FR0187, MO0219, SA0395, SU0277, SU0296, SU0366, SU0425 Kim, H. MO0219, MO0219, MO0291, MO0302, MO0443, SA0257, SA0257, SA0288, SA0395, SU0010, SU0209, SU0296, SU0406, SU0425 Kim, H. K. MO0074 Kim, J. FR0392, MO0087, MO0148, MO0236, MO0302, MO0443, SA0288, SA0376, SU0215 Kim, K. MO0212, MO0212, SA0276, SA0374, SA0374, SU0249, SU0249, SU0323, SU0323, SU0379, SU0379 Kim, M. SA0016, SA0376 Kim, S. 1087, 1138, FR0392, MO0021, MO0219, MO0236, MO0286, MO0291, MO0443, SA0269, SA0269, SA0374, SA0376, SA0376, SA0395, SA0406, SU0021, SU0248, SU0296, SU0366, SU0406, SU0470 Kim, T. MO0291, MO0379, SA0345, SA0398 Kim, W. SA0257, SU0201 Kim, Y. MO0286, MO0434, SU0036, SU0196, SU0366 Kimmel, C. SA0098 Kimmel, D. B. MO0318, SU0105, SU0320 Kimura, S. FR0464, SA0464, SU0131 Kindblom, J. M. 1179 Kindblom, l. SU0144 Kindundu, C. SA0429 King, D. SU0162 King, E. SA0171 King, K. SU0334 King, K. B. SU0112 King, S. MO0453 Kingwell, E. SU0370 Kinto, S. SA0280 Kirazli, Y. MO0387 Kirimoto, H. SU0069 Kirkwood, K. L. 1111, MO0244 Kirmani, S. 1176 Kishikawa, Y. SA0322 Kishimoto, H. 1201 Kiss, L. MO0180 Kita, K. SA0472 Kitagawa, F. MO0324 Kitagawa, M. MO0449 Kitamura, D. SA0274 Kitamura, T. SU0177 Kitazawa, R. SA0280, SU0256 337

Index

Kawelke, N. MO0234 Kaye, A. SA0318 Kazakia, G. J. MO0049, SU0077 Ke, H. 1069, 1208, FR0465, MO0312, MO0458, MO0461, MO0462, SA0461, SU0267, SU0463, SU0464 Kearns, A. E. SA0389, SU0170 Keaveny, T. M. 1204 Kedlaya, R. SU0127 Keenawinna, L. SU0145 Keller, G. MO0488 Keller, H. MO0307 Kellerman, O. MO0100 Kellokumpu-Lehtinen, P. MO0134 Kelly, J. 1109, MO0139, SU0142 Kelly, K. SU0132 Kelly, M. SA0031, SU0123 Kelly, N. MO0066 Kemp, J. SA0196, SU0368 Kenan, Y. SA0417, SU0468 Kendall, S. MO0140 Kendler, D. 1203, MO0442 Kendler, D. L. MO0331, MO0425 Kennedy, C. C. MO0453 Kennedy, O. 1105, SU0038 Kenny, A. M SU0410 Kerkhof, H. SU0198 Kerr, D. A. MO0345 Kersh, L. MO0358 Kesavalu, L. SA0152, SU0105 Kesavan, C. 1221, SU0221 Keshtkar, D. MO0338 Kesterson, B. 1188 Kesterson, R. SA0272 Keyak, J. H. FR0061, SU0052, SU0356 Khajia, R. SU0154 Khaled, A. MO0073 Khalil, N. SA0342 Khamessan, A. 1140 Khan, A. MO0416 Khan, M. MO0221 Khan, N. MO0416 Khan, S. MO0145 Khan, T. FR0299 Khaw, K. 1036, 1084 Khoo, B. MO0345, SA0033 Khor, E. MO0296, MO0300 Khosla, S. 1045, 1076, 1095, 1176, MO0277, MO0478, SA0047, SA0228, SA0239, SA0270, SA0389, SU0054 Khusainova, R. SA0358 Ki, K. FR0392, SA0269 Kiang, A. SU0141 Kiani, A. 1074 Kiel, D. P. 1084, 1165, FR0011, FR0013, FR0347, FR0367, FR0383, MO0198, MO0348, MO0352, SA0358, SA0365, SA0366, SA0380, SU0014, SU0036, SU0367, SU0372, SU0376 Kiernan, J. J. SA0261 Kiffe, M. MO0463 Kiffer-Moreira, T. FR0186, SA0186 Kihara, T. SU0205

Kitazawa, S. SA0280 Kitchin, E. SA0434 Kiviranta, R. 1145, 1216 Kivitz, A. MO0442 Kiyokawa, I. SU0325 Kizivat, T. SA0237 Klassen, P. SU0355 Klaushofer, K. MO0158, MO0178, MO0411, SA0058, SU0035, SU0063, SU0099 Klein, G. L. SU0393 Klein, R. F. SU0192 Klein-Hitpass, L. MO0001 Klein-Nulend, J. MO0067, MO0310, SU0313 Kleinmond, C. SA0432 Kneissel, M. 1040, MO0307, MO0463, SA0128 Kniepeiss, D. SA0424 Knight, J. MO0135 Knippels, I. SU0054 Ko, S. SA0341, SU0375 Kobayashi, K. SA0068, SA0266, SU0219 Kobayashi, T. 1012, 1116, 1154, SA0128 Kobayashi, Y. SA0477 Kochba, E. SA0417, SU0468 Kocijan, R. FR0332, FR0418, MO0397, SA0043, SU0333, SU0418 Kocjan, T. MO0438 Kodama, H. MO0359 Kodani, N. SU0202 Kode, A. 1205, SA0217 Koenig, M. SA0456 Koga, D. MO0090 Koga, T. FR0232, SA0232 Kogawa, M. 1042 Kogo, M. MO0316 Koh, A. 1088, SA0109, SA0139 Koh, J. MO0219, SA0358, SA0395, SU0240, SU0248, SU0296, SU0366, SU0425 Koh-Paige, A. MO0111 Kohler, T. 1202, MO0391 Kohno, H. MO0449 Kohri, K. MO0415 Koike, T. SU0178 Koinuma, N. MO0322 Koivumaa-Honkanen, H. MO0376 Kojima, Y. SU0471 Kokabu, S. 1120, 1149, MO0199, SA0244 Koller, D. FR0367, MO0196, SA0358, SA0367 Kollia, P. SA0358 Kolodziejczak, K. SA0306 Kolouskova, S. FR0158 Komarova, S. V. FR0252 Komatsu, D. E. MO0099, SU0117 Komatsu, K. MO0095 Komiya, S. MO0091, SU0244 Komori, T. SU0256 Konda, T. MO0050, SA0065 Kondabolu, S. SU0117 Kondo, T. SA0280 Kondo, Y. SU0202 Kondoh, S. SA0310, SA0483 Kondrikova, G. SA0213 338

Konishi, Y. Konstantinos, G. Kontulainen, S. A.

FR0121, SA0121 MO0122 1175, MO0008, SA0051, SU0015 Koo, H. SU0366 Koo, K. SU0434 Kooperberg, C. 1020, MO0373, SU0352, SU0369 Koopmann, W. FR0475 Kopperdahl, D. L. 1204 Kora´nyi, L. MO0180 Korbonits, M. 1215 Korkalainen, M. SA0108, SU0257 Korn, R. 1030 Kornak, J. SA0400 Kosa, J. P. MO0180 Koshimizu, T. FR0094, SA0094 Koskela, A. SU0257 Koskinen, J. MO0047 Kostenuik, P. J. SA0058 Koster, A. 1212 Kostev, K. SA0437 Kothari, V. MO0470 Kotowicz, M. A. SA0481, SU0012, SU0341, SU0492 Kotsiopriftis, M. MO0205 Koumakis, E. MO0034, SA0167 Kousteni, S. 1205, 1231, SA0217 Kovacs, C. S. FR0384, SU0173, SU0350 Koyama, E. SA0127 Koyano, K. SU0284, SU0287 Kozai, M. MO0128, SA0118 Kozhemyakina, E. 1194 Kozloff, K. M. 1185, SA0109, SU0102 Kro¨ger, H. MO0375, MO0376 Kraenzlin, C. SA0425 Kraenzlin, M. SA0425 Krahl, E. MO0468 Kram, V. SU0226, SU0392 Kramer, I. 1040, MO0307, MO0463 Krasnoperov, V. 1257 Kraus, V. SU0468 Krause, D. 1037, 1134, SU0445 Kravitz, B. G. 1211, MO0261, SA0400, SU0046 Kream, B. E. 1073 Krebsbach, P. H. MO0229 Krege, J. H. 1055, MO0330 Kreher, N. SU0032 Kreider, J. MO0229, SU0254 Kreiger, N. FR0384, SU0350, SU0370 Kremer, R. 1100, MO0481, SA0021, SU0208 Krestin, G. SU0364 Krevvata, M. 1231 Krieg, M. 1036, 1065, MO0162 Krieger, N. S. 1055, MO0121, SU0255 Krishnan, S. SU0369 Kristensen, H. Bjoerg 1173 Kristianto, J. SU0072 Kritchevsky, S. SU0258 Kroger, H. 1036, FR0182, MO0339 Krohn, K. 1204 Author Index

Kronenberg, H. M.

L Łasiewicki, A. Leˆ, O. Lo´pez-Aumatell, R. Lo´pez-Pena, M. Author Index

SU0374 SA0265 MO0196 SA0101

Lo¨yttyniemi, E. SU0451 Lu¨then, F. MO0257 L’abbe, M. 1140 La Croix, A. 1036 La Rocca Vieira, R. MO0426 Laaksonen, M. SA0196, SU0020, SU0368 Labine, L. SU0355 Lacey, D. 1080 Lacroix, A. MO0341 Lacroix, A. Z. 1020, MO0373, MO0377, SA0377, SU0352, SU0369 Lafleur, J. SA0372, SU0342 Lagace´, C. SA0362 Lagari, V. SA0037 Lagast, H. MO0170, SA0170 Lagerquist, M. K. FR0482, MO0479, SU0483 Lahiri, S. MO0168 Lai, D. FR0367 Lai, F. 1194, SA0274 Lai, T. SU0373 Lai, Y. 1046 Laib, A. 1236 Laing, E. M. MO0023, MO0482, MO0483, SU0025, SU0028 Lajeunesse, D. FR0233 Lakatos, P. MO0180 Lal, Md, A. MO0446 Lala, D. MO0040 Lalcikova, E. MO0329 Lam, K. 1025 Lamberg-Allardt, C. J. E. 1180 Lambers, F. FR0069 Lambert, D. MO0355 Lambert, R. 1136 Lambertini, E. SU0246 Lamghari, M. MO0233 Lamy, O. MO0162 Lan, S. MO0092 Landicho, M. MO0166 Landin, L. FR0020 Landin-Wilhelmsen, K. L. MO0357, MO0370 Landy, H. MO0193, SU0032 Lane, D. SA0134 Lane, J. M MO0461, SU0365 Lane, N. SA0479 Lane, N. E. 1025, 1252, SA0064, SA0467, SU0002, SU0045, SU0317 Lane, T. 1116 Lang, B. SA0019 Lang, T. FR0061, MO0415, SA0400 Lang, T. F. MO0036, MO0408, SA0365, SU0052, SU0356 Langdahl, B. MO0186, MO0442 Langdahl, B. L. FR0453, SA0358 Lange, J. MO0430 Langenbach, G. SA0298 Langhammer, A. SA0369 Langman, C. B. FR0423, SU0031 Langsetmo, L. 1055, FR0384, SU0173, SU0350, SU0370 Lanham-New, S. A. SA0370, SU0353 339

Index

1116, 1194, MO0126, SA0128, SU0087 Kronenberg, M. 1005 Krueger, D. C. FR0330, MO0012, MO0454, SA0330, SU0006 Kruger, E. Alfonso FR0205 Krust, A. FR0482, MO0479 Ksie˛z˙opolska-Orłowska, K. SU0374 Ku, S. MO0443 Kubota, S. 1161 Kubota, T. SU0071 Kudo, A. SA0292 Kudo, D. SU0475 Kuehne, F. FR0332 Kugimiya, F. 1011 Kuhn, G. FR0069, SA0069 Kuhn, L. SA0463 Kuipers, A. SA0364, SU0197 Kukita, A. SU0284, SU0287 Kukita, T. SU0284, SU0287 Kukreja, S. MO0388 Kular, J. SU0280 Kuliwaba, J. SA0314, SA0316 Kulkarni, R. MO0310, SU0313 Kull, M. SU0013 Kumar, A. MO0285, SU0286 Kumar, J. MO0367 Kumar, R. 1079, 1210, MO0188, SU0091 Kumbhani, R. MO0120, SU0404 Kummari, S. MO0037 Kumode, M. MO0449 Kung, A. WC 1084, MO0198, SA0358 Kunii, I. FR0195 Kunishige, A. FR0044, SA0180, SU0473 Kuno, M. SU0229 Kuo, C. MO0148 Kupke, J. 1238, SA0040 Kurihara, N. 1046, 1184, FR0165, FR0166, SA0155, SU0490 Kurimoto, P. SA0461, SU0463 Kuro-O, M. SU0487 Kuroda, T. SU0423 Kurosaka, H. SU0265, SU0319 Kurten, R. 1192 Kutilek, S. MO0028 Kuwabara, A. MO0449 Kuwayama, T. 1135, FR0448, FR0449 Kwak, J. 1117, FR0088 Kwan, J. MO0198 Kwok, T. SU0125 Kwon, A. SA0251 Kwon, R. Y. SU0070 Kwon, S. MO0213 Kwon, T. MO0418, SU0215 Kwong, M. 1015 Kyvernitakis, I. SA0437

Lankinen, P. Lanovaz, J. Lanske, B. Lanyon, L. E. Lanza, G. Laplanche, J. Lapointe, D. Lappe, J. Lappe, J. M.

SA0421 1175, SA0051 1054, SA0120 MO0215 SA0071 MO0189 SA0146 MO0391 1143, 1200, 1202, FR0492, SA0415, SU0414 Lara, N. FR0005, MO0005, SU0001 Lardiello, S. MO0393 Largura, H. FR0307 Larijani, D. MO0338 Larrosa, M. SU0420 Larson, E. SU0192 Larson, M. MO0198 Larsson, B. MO0485 Larsson, C. SU0394 Larsson, T. SA0203 Larue, A. 1077 Lassar, A. 1194 Laster, A. J. SU0326 Lastwika, K. SU0132 Lattmann, R. MO0463 Lau, A. N. SU0136 Lau, E. 1036, SA0281 Lau, K. 1038, 1071, 1078, FR0319, MO0207, MO0470, SA0015 Laudermilk, M. MO0026 Lauing, K. L. SU0223 Launay, J. MO0189 Laurie, D. SA0171, SU0457 Lautenschlager, N. SU0009 Lauzier, D. MO0205 Lawlor, D. MO0025, SU0022 Layfield, R. 1082 Layh-Schmitt, G. SU0295 Lazar, V. MO0160 Lazar-Antman, M. SU0019 Lazard, Z. MO0108, SU0040 Lazarenko, O. MO0262, SA0023 Lazaretti Castro, M. FR0195, SA0346 Lazzari, A. MO0063 Le Bailly De Tilleghem, C. FR0453 Le Goff, B. MO0209 Le Loe¨t, X. MO0437 Le, P. 1213, MO0222 Le, T. SA0356 Leach, J. SU0153 Lebecque, p. SA0458 Lebl, J. FR0158 Leblanc, A. MO0415 Leblanc, E. MO0349 Leboff, M. S. MO0342, SU0282, SU0400 Lecanda, F. 1232 Lecka-Czernik, B. Anna 1213, 1227 Leder, B. Z. 1101, MO0120, SU0404 Lee, B. 1008, 1083, 1085, MO0100, MO0107, MO0246, SU0018, SU0062, SU0081, SU0093, SU0450 Lee, C. MO0379, SU0007, SU0079, SU0382 Lee, C. G. MO0347, SA0388 340

Lee, Lee, Lee, Lee,

D. E. G. H.

MO0443, SA0374, SU0323 SU0215, SU0277, SU0289 MO0192 1101, FR0187, MO0053, MO0093, SA0187, SA0251, SA0398, SU0433 Lee, J. 1099, MO0053, MO0053, MO0302, SA0168, SU0105, SU0205, SU0366 Lee, K. MO0123, MO0406, SU0240, SU0248 Lee, K. L SA0075 Lee, M. 1117, 1144, FR0088, MO0195, SA0154, SA0342, SA0379, SU0366 Lee, N. J. 1002 Lee, R. SU0019, SU0385 Lee, S. 1167, FR0487, MO0219, MO0219, MO0279, MO0291, SA0275, SA0276, SA0395, SA0395, SA0395, SA0487, SU0196, SU0248, SU0296, SU0296, SU0366, SU0375, SU0406, SU0425 Lee, T. MO0042, SA0373, SU0064, SU0270 Lee, V. MO0026 Lee, W. MO0321 Lee, Y. 1138, MO0219, MO0356, SA0257, SA0257, SU0296, SU0361, SU0434 Lee, Z. MO0302 Leenen, P. MO0289 Leet, A. I. SU0019 Legeai-Mallet, L. 1018 Legeros, R. SA0474, SU0039 Legrand, E. R. SU0082 Lehtima¨ki, T. SA0196, SU0020, SU0368 Lehtimaki, T. 1084, SA0358 Lei, S. 1174 Leib, E. S. SA0387 Leibson, C. MO0170, SA0170 Lember, M. SU0013 Lemon, C. MO0398 Lems, W. MO0310 Lenane, Z. MO0172 Lendhey, M. SU0038 Lenge, L. SA0008 Lennox, J. FR0405 Lentle, B. 1055, FR0030, MO0416, SA0019 Lentzsch, S. 1090 Leonard, G. SA0221 Leonard, M. B. 1092, MO0183, SA0029, SU0194 Leoncini, G. SA0159 Leong, D. 1105, SU0115 Leong, J. MO0119 Leotoing, L. MO0002, SU0294 Leow, S. MO0060 Leppanen, O. SU0073 Lequerre, T. MO0437 Lerner, S. SA0018 Lerner, U. SA0010 Lerner, U. H. MO0271, MO0275, SA0378 Leroyer, P. SU0243 Lesage, E. MO0006 Leshem, Y. SU0468 Leslie, J. Marie 1001 Author Index

Author Index

Liebling, D. FR0423 Lien, M. SU0067 Lier, D. 1136 Lietman, C. 1083, MO0107 Lieu, S. MO0223 Lii, J. SU0437 Lillholm, M. MO0041, SU0337 Lim, B. SU0280 Lim, C. SU0270 Lim, E. MO0148, SA0150 Lim, K. MO0087, MO0236 Lim, M. MO0213 Lim, S. MO0212, SA0406, SU0249, SU0379, SU0406 Lim, V. 1080 Lima, F. 1238, MO0149 Limoli, C. MO0285, SU0286 Lin, C. SU0060 Lin, H. SA0468 Lin, J. MO0156, SA0100, SU0103 Lin, L. SU0060, SU0393 Lin, M. SU0245 Lin, P. MO0132 Lin, S. MO0112, SA0105, SU0245 Linares, G. 1172 Lind, B. SU0494 Lindahl, A. MO0357, MO0370 Lindberg, I. SA0032 Lindenmaier, L. 1004 Lindgren, U. FR0004, SA0203 Lindholm, C. MO0275 Lindsay, R. 1133, 1203, MO0369, MO0413, SA0377, SU0062 Lindstedt, G. MO0357, MO0370 Lindstrom, E. SU0474 Ling, W. MO0145 Link, T. FR0061, SA0049 Linn, S. SA0338 Linneman, J. 1131 Linossier, M. SA0077 Liphardt, A. SU0050 Lippuner, K. 1066, SA0035, SA0360, SU0357 Lips, P. T. SA0358, SA0397, SA0495 Lira, A. SA0245 Lirani-Galvao, A. Paula SA0346 Lisignoli, G. MO0230, SU0246 Lisse, J. R. MO0026 Lisse, T. MO0480, MO0484, SU0318 Litscher, S. SU0072 Little, D. FR0157, FR0465, SA0323, SA0465 Little, G. H. MO0136, MO0137 Litwack-Harrison, S. SU0348 Liu, C. 1084, 1165, FR0367, MO0311, SA0358, SA0365, SA0366, SU0367, SU0376 Liu, D. SU0224 Liu, F. MO0129, MO0229 Liu, G. MO0036, MO0044 Liu, H. FR0289, SA0289, SU0461 Liu, J. 1044, 1052, 1139, FR0290, MO0260, MO0293 Liu, K. 1090 Liu, L. SU0146 341

Index

Leslie, W. D. 1031, 1036, 1056, 1084, 1091, 1244, 1251, FR0331, MO0433, SA0331, SA0358, SA0362, SA0438, SU0347, SU0355, SU0369 Lespessailles, E. MO0043, MO0060, MO0062, MO0076 Leucht, P. FR0078 Leung, A. T. FR0453 Leung, P. SU0125 Leupin, O. MO0307 Levin, G. SU0468 Levine, A. Beth SU0441 Levinger, I. MO0014 Levis, S. SA0037 Levy, S. M. MO0046 Lewiecki, E. 1061, 1062, 1203, MO0442 Lewis, C. E MO0452 Lewis, G. FR0223 Lewis, J. Richard 1163 Lewis, R. D. MO0023, MO0482, MO0483, SU0025, SU0028 Lezot, f. SA0112 Li, A. 1049, 1146, MO0085, MO0475 Li, C. 1059, 1171, MO0461, SU0045, SU0464 Li, D. FR0079 Li, F. MO0099 Li, G. 1026 Li, H. 1005 Li, J. 1116, MO0481, SA0128, SA0201, SU0226 Li, L. MO0147, MO0267, SU0208 Li, M. MO0315 Li, Q. SA0188 Li, S. MO0140 Li, T. 1123, 1126, MO0084, SA0202, SA0476, SU0245 Li, W. 1117, MO0235 Li, X. 1206, 1208, 1225, FR0206, FR0299, MO0145, MO0188, MO0347, MO0408, SA0049, SA0222, SA0294, SA0388 Li, Y. 1014, 1254, FR0004, FR0074, MO0084, SA0004, SA0074, SA0202, SA0203, SA0249, SA0293, SA0304, SU0284, SU0287 Li, Z. 1217, MO0094 Li, y. 1126 Lian, J. MO0434, MO0481 Lian, J. B. 1152, 1217, FR0312, MO0240, SA0146, SA0224, SA0236, SA0242, SA0243, SU0234 Lian, Y. 1093, SU0336 Liang, B. 1008 Liang, G. 1153, SA0318 Liang, K. 1014 Liang, N. 1146 Liang, Q. 1233 Liang, S. MO0148 Liao, V. SU0062 Libanati, C. 1062, 1063, 1064, 1065, MO0442, SU0455 Libber, J. FR0330 Lichtler, A. 1073, MO0159, SA0258, SU0269 Lieben, L. FR0235, SA0235 Lieberman, J. R. MO0312

Liu, M.

FR0465, MO0126, MO0458, MO0462, SA0461, SU0463 Liu, R. 1025, SU0166 Liu, S. 1124, FR0177 Liu, X. Sherry 1107, 1132, 1200, MO0044, MO0176, SA0048, SA0176, SU0328, SU0340, SU0414 Liu, Y. 1084, 1174, MO0046, SU0367 Liu, Z. FR0079, SA0130, SU0464 Liu, y. MO0112 Lix, L. 1031, 1056, 1091, 1244, FR0331, MO0433, SA0438 ¨. Ljunggren, O MO0442, SA0010 Ljunggren, O. 1021, SA0358, SA0378, SU0125 Lloyd, J. MO0374 Lloyd, S. 1239 Lo, J. C. SU0458 Locher, J. SA0434 Lofthus, C. 1261 Loghin, C. SA0417 Lohfeld, L. MO0453 Lohman, T. MO0026 Loiodice, S. SU0098 Loiselle, A. FR0223, SA0223 Lok, C. MO0177, SU0175 Lombardi, A. FR0453 Long, C. SU0303 Long, F. 1086 Long, J. MO0032 Long, J. P. FR0074, MO0231 Longobardi, L. 1123, 1126, MO0084, SA0202 Loog, M. MO0041 Loots, G. G. FR0208, MO0157, SA0093 Lopes, J. Barros MO0363, SU0362 Lopez, B. SU0349 Lopez, J. MO0032 Lopez-Cruzan, M. SA0408 Lore´al, O. SU0243 Lorean, A. MO0392 Lorentzon, M. 1084, 1179, FR0026, FR0199, MO0198, SA0010, SA0196, SA0378, SU0368 Lorenzo, J. MO0279, MO0400, SA0395, SU0410 Lorget, F. 1018 Losina, E. SU0437 Loth, E. SU0374 Lotinun, S. 1003, 1034, 1037 Lotz, J. FR0391 Lou, Y. FR0224, SA0224 Louie-Gao, Q. SU0036 Louis, L. 1034, 1213, FR0025 Lovell, F. MO0361 Lowe, D. SU0024 Lowe, G. MO0140 Lozano, D. MO0007, SU0203 Lozano, R. SU0203 Lu, B. 1046, MO0373, SU0352 Lu, C. SU0230 Lu, H. FR0206 Lu, J. MO0184, SU0033 Lu, M. SU0394 342

Lu, Q. MO0220 Lu, R. SU0122 Lu, W. FR0391, MO0127, MO0241, SA0309 Lu, W. W. 1006 Lu, X. MO0243 Lu, Y. 1227, 1237, MO0112, SA0111, SA0111 Luangphakdy, V. MO0103 Lubberts, E. SA0277 Luben, R. 1084 Lublinsky, S. SA0076 Lucani, B. MO0337, MO0393 Lucas, E. A. SA0399, SU0399 Lucero, D. SU0398 Luchini Batista, S. MO0167 Luciotti, M. MO0253 Lucisano, M. SU0466 Luderer, H. 1112 Lueger, S. MO0178 Lui, L. 1242, SU0358 Lui, L. L. 1058, 1059, 1263, FR0411, MO0349, SU0422, SU0448 Luis-Ravelo, D. 1232 Lukashova, L. SA0084 Lukefahr, A. L. SU0390 Lumpkin, C. K MO0269, SU0146 Lundberg, Y. W. 1174, MO0096 Lunetta, K. SU0372 Lunos, S. SU0153 Luo, G. MO0255, SU0340 Luo, J. SA0133 Luo, M. 1046 Luoto, R. MO0134 Luque-Ferna´ndez, I. SU0332 Lusis, A. SA0245 Lussier, B. 1150 Luyten, F. SA0262 Ly, F. SU0364 Lyles, K. W. 1247, SU0385 Lyons, D. SA0184 Lyons, K. M. SU0110 Lyytika¨inen, L. SA0196, SU0368

M M Alves, M. Me´ary, F. Mu¨ller, R. Ma, B. Ma, G. Ma, Y. L. Maalouf, D. Maas, A. Maasalu, K. Mabuchi, A. Mac Way, F. Mac-Way, F. Macarios, D. Macchi, V. Macdermid, J. Macdonald, C. Macdonald, H.

MO0362 SU0098 1202, FR0069 SU0077 MO0083, SU0230 FR0414, SU0130 MO0338 SU0486 SU0421 1011 SA0077 SA0014 SU0455 SU0322 SU0017 MO0447 MO0021, SU0021, SU0037, SU0050 Author Index

Author Index

Manavalan, J. 1231, MO0261 Mancini, D. SU0430 Mandair, G. S. MO0032 Mandal, C. C. SU0133 Manferdini, C. MO0230 Manickam, B. MO0388 Manicourt, D. 1070 Manigrasso, M. 1169, SU0395 Manjubala, I. SU0035 Mann, V. 1224 Manning, C. SA0201, SU0234 Mannix, J. MO0118 Mannstadt, M. MO0191 Manoharan, R. FR0131 Manolagas, S. 1039, 1041, 1110, 1168, 1189, 1209, FR0002, FR0409, MO0476, SU0128, SU0470 Manolagas, S. C. 1014, 1192 Manolson, M. F. 1016, MO0280 Manrique, P. SU0349 Manske, S. L. FR0070, MO0065, SA0070 Mansky, K. C. SU0307 Manson, J. E. SU0448 Mantila Roosa, S. M. 1104, SU0402 Maran, A. MO0151 Marathe, N. MO0245, SU0480 Maravic, M. 1245 Marc, J. MO0438, SA0358 March, R. SU0330 Marchall, R. SU0033 Marchetti, J. 1238, SA0040 Marcocci, C. MO0165, SA0172, SU0169 Marcucci, G. MO0226, SA0159 Marcussen, P. 1173 Marie, P. J. 1214, MO0152, SU0476 Marin, F. FR0413, FR0414 Marini, F. MO0268 Marini, J. 1015, SA0084 Marini, J. C. 1185, MO0158, SU0189 Marino, V. SA0181, SU0300 Mario, G. FR0206 Markku, A. SU0411 Markmiller, D. MO0143 Marlow, B. MO0119 Marotte, C. MO0490, SU0398 Marr, S. MO0453 Marsden, P. FR0419, MO0422 Marshall, L. M. MO0343, SA0012, SA0036 Marshall, R. SA0189 Martı´n-Ferna´ndez, M. SU0462 Martı´n-Gutie´rrez, L. SU0176 Martı´nez-Canarias, S. 1232 Martı´nez-Membrives, E. MO0196 Martain, S. MO0489 Martel-Pelletier, J. 1150, FR0233 Martell, J. SA0001 Martens, M. SU0485, SU0486 Martin Millan, M. 1160 Martin, B. R. MO0023, MO0321, MO0477, MO0482, SA0175, SU0025 Martin, E. MO0343 Martin, T. 1257, MO0209, SA0141, SA0230, SA0298, SU0148 343

Index

Macdonald, H. M. MO0447, SA0457 Macdougald, O. 1227 Machado, A. Braga De Castro MO0362 Machado, W. MO0362 Macias, B. Richard MO0149, MO0227, SA0226 Macica, C. M. SA0318 Macintyre, N. J. SA0333, SU0017 Mackenzie, N. MO0185 Mackey, D. C. SA0359 Mackie, E. J. MO0210 Macleay, J. MO0058 Macrae, K. Eva SU0252 Macrae, V. MO0185, SA0186, SU0092 Madalena Palomari Spolidorio, D. MO0228 Madhu, V. FR0268 Madson, K. SA0024, SU0032, SU0185 Mady, L. SA0488, SU0487 Maeda, A. FR0124, SA0124, SU0110 Maeda, M. SA0121 Maeda, N. SA0121 Maeda, S. MO0091, SU0244 Maeda, Y. 1155, 1217, SU0119 Maekawa, M. SU0131 Maeno, M. SU0220 Magaril, C. SU0421 Magaziner, J. 1096 Maguire, P. SU0330 Magyar, C. FR0253 Mahadevan-Jansen, A. MO0079 Mahalingam, C. SU0254 Mahdavi-Mazdeh, D. MO0338 Mahon, J. MO0323 Mahon, M. SA0124 Mahoney, E. SA0091 Maier, R. 1199 Maile, L. MO0222 Mailhot, P. MO0241, SA0309 Main, R. P. 1106 Mait, J. MO0461 Majeska, R. J. 1105, SU0038, SU0115 Majid, A. SA0317 Majumdar, S. MO0049, MO0412, SA0047, SA0049, SU0077 Majumdar, S. R. 1031, 1056, 1136, FR0438, SA0438 Makepeace, N. MO0456 Makhijani, N. S. FR0205 Maki, K. SU0263 Makino, M. MO0324, SA0324, SU0119 Makino, Y. MO0266 Makitie, O. 1180, FR0182, MO0407 Makowski, A. FR0059, MO0079 Malagoli, E. SU0322 Malik, K. SU0136 Malluche, H. H. 1057 Mamdani, M. SU0431 Mamillapalli, R. 1053 Man, C. SU0464 Man, Z. 1065, SU0164, SU0421 Manako, J. FR0448 Manal, K. MO0030 Manassra, R. MO0007

Martin-Coe, L. SU0218 Martin-Millan, M. 1110 Martinez De Osaba, M. MO0232, SA0459 Martinez Diaz-Guerra, G. MO0024 Martinez, E. SU0462 Martinez-Ferrer, A. MO0232, SA0459 Martinez-Garcia, M. MO0131, SU0140 Martinez-Laguna, D. FR0385 Martini, L. A. MO0004, SA0343 Martins, G. 1072 Martorell, J. SA0315 Martos, G. MO0024 Martus, P. MO0455 Marty, C. MO0152, SU0476 Mascarenhas, M. G. MO0390, SU0440 Masgrau, A. SA0077 Masgraud, A. SA0014 Masi, L. SA0159 Masiukiewicz, U. MO0061 Mason, D. J. SA0227 Mason, J. SA0087, SA0097 Mason, R. SU0048 Massari, F. Enrique SA0396 Massarotti, M. Sergio SU0447 Mastaglia, S. MO0488, MO0490, SU0344 Mastaviciute, A. MO0013 Masters, B. 1017 Masuda, H. 1190, MO0282, SU0297 Masuda, M. MO0128, SA0118 Masunari, N. 1060 Mathsyaraja, H. SU0288 Matic, I. SA0237 Matos, Y. SU0103 Matsubara, H. 1119 Matsubara, M. SA0472 Matsubara, T. MO0272 Matsuki, Y. SU0325 Matsumoto, C. MO0182, SA0401 Matsumoto, H. SA0462, SU0465 Matsumoto, K. SU0283 Matsumoto, T. 1190, 1229, MO0282, MO0415, SA0054, SA0143, SA0483 Matsumoto, Y. SU0187 Matsumura, T. SA0472 Matsuo, K. 1150, 1161, MO0276, SU0308 Matsuo, Y. SA0464 Matthew, E. SA0133 Matthews, B. SA0105 Matthews, R. 1247, FR0433, MO0419, SU0427 Mattocks, M. MO0251 Matzelle, M. M. FR0201, SA0201, SU0234 Matzinger, M. FR0030, SA0019 Maul, D. SU0474 Maurel, D. Blandine FR0402, SA0402 Maurizi, A. SU0409 Maury, E. MO0034 Mautalen, C. 1062, SU0344 Mautalen, C. A. SU0421 Mavilia, C. MO0226, MO0268 Mavroeidi, A. SA0457 Mawad, H. 1057 Maxson, R. SA0160 344

Maxwell, R. SU0330 May, R. 1059 Maycas, M. SA0308 Maye, P. 1005, MO0086, MO0187 Mayhew, P. M. 1127 Mayo, N. 1100 Mayranpaa, M. FR0182 Maziar, D. MO0338 Mazor, Z. W. MO0455 Mbala, A. 1129, SU0334 Mbalaviele, G. 1115, 1148, 1222, 1256 Mcalister, F. 1136 Mcalister, W. 1080, SA0024, SU0185 Mcandrew, J. MO0323 Mccabe, G. MO0023, MO0467, MO0477, SA0175, SU0469 Mccabe, L. MO0477 Mccabe, L. R. SU0218 Mccallum, R. MO0453 Mccarthy, S. Anne SU0143 Mccauley, L. K. 1075, 1088, MO0111, SA0109, SA0139, SA0294 Mccloskey, E. MO0038 Mccloskey, E. V. 1036, 1091, MO0358, SA0328, SA0378, SA0381, SU0158, SU0369 Mcclung, M. R. 1061, SU0421 Mccorry, M. FR0312 Mccoy, K. SA0148 Mccracken, P. MO0037, SU0066 Mccreedy, R. SA0188 Mccue, A. 1238, SA0040 Mcdonald, M. Maree FR0465 Mcdonald-Blumer, H. SA0420 Mcelderry, J. SA0085 Mcgee-Lawrence, M. E. 1152, MO0460 Mcgeough, M. 1115 Mcgowan, K. SA0220 Mcgregor, N. 1048 Mcguigan, F. FR0327, MO0367, SA0363 Mcguirt, J. 1077 Mcgurk, C. MO0358 Mckay, H. A. MO0021, SU0021 Mckee, M. D. FR0209 Mckenna, M. J. SA0161 Mckenna, R. SA0134 Mckie, J. SA0323 Mckiernan, F. E. 1131, SU0195 Mckoy, J. FR0423 Mclean, R. R. FR0011, MO0348, SA0011, SU0014 Mclellan, A. R. MO0361, SA0351 Mcmahon, D. 1099, MO0036, SA0168 Mcmahon, D. J. 1092, 1097, 1132, 1200, MO0044, MO0172, MO0176, MO0261, MO0332, SA0018, SA0047, SA0048, SA0176, SA0415, SU0179, SU0328, SU0340, SU0371, SU0414, SU0430 Mcnulty, M. MO0188, SU0091 Mcnulty, M. A. MO0106 Mecham, R. SA0296 Medin, P. SU0154 Medina-Gomez, C. 1084, 1142 Meeks, B. SA0241 Author Index

Author Index

Miljkovic, I. SA0364 Milla´n, J. SA0186 Millan, J. FR0193, MO0081, MO0102, MO0109, MO0185, SA0125, SU0109 Millard, S. FR0391, MO0241 Miller, B. SA0123 Miller, C. SU0046 Miller, C. G. FR0335, SA0335 Miller, J. SU0117 Miller, K. K. MO0191 Miller, L. M. MO0057, SU0061 Miller, M. MO0142, SU0007, SU0382 Miller, P. MO0442 Miller, P. D. 1061, 1203, SU0421 Miller, T. MO0204 Miller-Martinez, D. SU0358 Milley, K. SA0141 Milliner, D. 1079 Millione, A. SU0152 Minami, Y. FR0095 Minamizaki, T. SA0121 Minematsu, A. SU0396 Mingione, A. MO0163 Minisola, S. MO0372, SA0008 Minkoff, J. R. SU0458 Minster, R. 1084, SA0358, SU0367 Miot Noirault, E. MO0002 Miranda, C. SU0397 Mirkin, S. 1133 Mirza, F. SA0395 Mirza, F. S. MO0400, SU0410 Misener, E. MO0147 Mishina, Y. 1073 Mishra, G. MO0265 Mishra, S. SU0117 Misof, B. FR0058, MO0178, SA0058, SU0063 Misra, S. 1177 Mitchell, B. D. FR0199, FR0367, SA0197, SU0367 Mitchell, J. MO0251 Mitchell, P. MO0362 Mitchell, P. James SA0351, SU0426 Mithal, A. MO0174 Mitta, S. MO0409 Mittmann, N. MO0351 Miura, D. SU0168 Miura, M. MO0449 Miura, T. SU0325 Miyagawa, K. MO0316, MO0427 Miyai, K. 1258 Miyajima, D. SA0102, SU0237 Miyakawa, M. SU0168 Miyakawa, N. SU0423 Miyakoshi, N. MO0359, MO0444, SA0426, SU0360, SU0419, SU0475 Miyamoto, A. SU0281 Miyamoto, H. 1157 Miyamoto, K. MO0126, MO0128, SA0118, SU0177 Miyamoto, T. 1157, SU0279 Miyamoto, Y. SU0281 Miyauchi, A. MO0417, SA0442 345

Index

Meganck, J. MO0148, SA0150 Meguerditchian, A. 1100 Mehrotra, M. 1077 Mehrotra, R. N. SU0129 Mehta, N. MO0409 Mei, L. SU0096 Meier, C. SA0425, SA0425 Meille, S. FR0062 Melhus, H. 1243 Meliton, V. MO0204 Mellibovsky, L. MO0055, MO0284 Mellor, L. SU0213 Mellstro¨m, D. 1065, 1179 Mellstrom, D. 1021, 1036, FR0010, FR0026, SA0010, SA0378, SU0125 Melo, A. SU0491 Melton, L. 1036, 1095, 1176, MO0354, SU0054 Melton, M. MO0452 Mendonca, M. SU0316 Menezes, T. MO0410, SU0417 Meng, L. 1025 Meng, X. 1078 Menuki, K. SA0096 Merchant, A. SU0285 Mercier, s. SU0294 Meredith, D. SA0083 Merkel, A. SA0140 Merle, B. MO0320 Merlotti, D. MO0163, MO0337, MO0393, SA0394 Merrild, D. SA0271, SU0401 Messmer, P. SA0058 Metge, C. 1056, SA0438 Metz, L. SA0014, SA0077 Metz-Estrella, D. SU0253 Meunier, M. MO0034 Mevorat, K. SU0468 Meyer, H. 1261, SA0386 Meyn, L. 1093 Miao, D. 1052, SU0122 Miccoli, P. MO0165, SU0169 Michaelsson, K. 1243, SU0354 Michalek, S. FR0290 Michalska, D. SA0326 Michalski, M. 1075, SA0109 Michel, R. MO0475 Michigami, T. FR0094, MO0190, MO0316 Michikami, I. FR0106, SA0106 Michou, L. MO0189 Miclau, T. MO0223 Miettinen, H. SA0108 Miettunen, P. FR0030, SA0019 Mihara, M. 1114, SU0477 Mikhail, M. B. MO0395 Miki, H. 1229, SA0143 Miki, R. 1083 Miki, T. MO0327 Mikkila¨, V. SA0196, SU0020, SU0368 Mikulec, K. FR0157, FR0465 Mikuni-Takagaki, Y. MO0316, SU0467 Mikuscheva, A. SA0136 Militianu, D. SU0438

Miyauchi, T. SU0263 Miyaura, C. FR0147, MO0182, SA0401 Mizoguchi, F. SU0237 Mizoguchi, T. SA0477 Mizukawa, N. SA0472 Mizuno, A. SU0237 Mo, C. FR0005, MO0005, SU0001 Moayyeri, A. 1084, SA0358 Mobley, J. MO0144 Modlesky, C. M. MO0030 Moe, S. SA0175 Moedder, U. I. 1076, MO0478 Moeller, G. SA0435 Moericke, R. SA0432 Moermans, K. FR0235 Moffatt, P. MO0205 Moffet, A. 1062 Mofield, A. SA0456 Mogami, A. MO0427 Mohammad, K. S. 1013, MO0133, SA0134, SA0222, SU0316 Mohan, S. 1092, 1122, 1172, 1178, 1221, MO0207, MO0214, SU0221, SU0328 Moharam, A. SA0113, SU0174 Moldovan, F. SA0247 Moldovan, I. MO0386 Molinolo, A. SA0031, SA0122 Momose, A. 1161 Monaghan, M. MO0068 Monarca, M. 1010 Monegal, A. FR0066, MO0232, SA0459 Monges, S. MO0027 Monks, A. SU0152 Monroe, D. G. MO0478, SA0239, SA0270 Mont, C. MO0196 Montecino, M. SA0146 Montesi, M. SU0084 Montgomery, C. SU0146 Montgrain, P. SA0153 Montoya, M. SU0397 Moon, H. SA0398 Moon, S. MO0093, SU0424, SU0433 Moore, A. FR0419, MO0422 Moore, D. FR0215 Moore, S. A. MO0021, SU0021 Moraitis, A. 1187 Morales-Santana, S. FR0407 Moran, E. SU0239, SU0262 Morancey, J. MO0434 Morasso, M. SA0242, SA0243 Moravits, D. SA0064 Moreau, A. FR0250, SA0250 Moreira, A. MO0167 Moreira, T. Kiffer MO0109, SA0125, SU0109 Morello, R. 1083, 1181 Moreno, L. 1182 Morgan, B. MO0104 Morgan, D. 1238, SA0040 Morgan, E. 1119, SA0055 Morgan, T. SU0192 Mori, G. SA0149 Mori, H. FR0044, SA0180, SU0473 346

Mori, K. Mori, T. Mori, Y. Morikawa, D.

SA0280 SA0096, SA0219, SU0279 1228 FR0068, SA0068, SA0266, SU0219 Morin, S. Nicole 1056, 1244, 1251, 1260, FR0331, MO0328, MO0331, MO0433, MO0453, SA0362, SA0438 Morioka, H. 1157 Morishima, T. SU0202 Morisky, D. SU0439 Morissette, J. MO0189 Morita, M. MO0237, SA0183 Morita, S. MO0090 Morita, Y. MO0141, SU0306 Moritz, N. SA0421 Moriwaki, S. MO0322 Moriyama, K. MO0237 Morko, J. SA0460, SU0042, SU0324 Moro, Y. SA0107, SU0086 Morohashi, T. SU0293 Morris, H. A. SA0493 Morris, M. MO0032, SA0087 Morris, M. D. SA0085, SA0179, SU0155 Morrisey, M. 1246, 1247, MO0439, SU0326, SU0427 Morrison, L. 1032 Morse, A. FR0465 Morse, L. MO0063, SU0301 Morse, L. R. MO0290, SU0466 Mortarino, P. SU0078 Mortlock, D. 1119 Mortlock, D. P. 1123, MO0084 Morvan, F. MO0307 Moscatelli, I. SA0298, SU0299 Mosekilde, L. 1098, MO0171, SA0169, SU0488 Moseychuk, O. 1198, SU0200 Mosialou, I. 1205, SA0217 Moskowitch, N. SU0289 Moss, R. SU0274 Motohashi, M. SU0220 Motoyoshi, T. SU0108 Motyl, K. 1034 Motzel, S. MO0037 Mourot, L. MO0181, SU0181 Moverare Skrtic, S. E. 1021, SU0483 Moyer-Mileur, L. J. MO0029, SU0030 Mun˜oz, F. SA0101 Mudano, A. S. MO0452, SA0434 Mueller, J. 1115 Mueller, c. SA0112 Mughal, M. SA0028 Mughal, Z. SA0478 Mugniery, E. 1018 Mukai, T. FR0190, FR0194, SA0194 Mukudai, Y. MO0473 Mulivor, A. 1210 Muller, R. MO0391 Mulrooney, B. MO0030 Mumm, S. 1080, SA0024, SU0185, SU0193 Mun, H. SU0478 Mun, S. SA0275 Author Index

N Nace, D. SU0007, SU0382 Nadeau, H. SA0286 Nadeau, L. 1100 Nadel, H. FR0030, SA0019 Nagae, A. MO0449 Nagamoto, Y. SU0407 Nagano, K. MO0221 Nagao, M. FR0114, MO0427, SA0114 Nagase, S. 1135, FR0448, FR0449, SA0448 Nagashima, K. SU0152 Nagatsuka, H. SA0472 Nagura, N. MO0427 Nagy, Z. MO0180 Nahal, A. MO0475 Nahar, U. MO0174 Nahhas, R. SA0052 Naik, S. MO0265 Najafova, Z. MO0263 Nakagawa, T. 1011, SA0107, SA0464, SU0086, SU0131 Nakahashi, O. MO0128, SA0118 Nakai, K. SU0220 Nakajima, M. MO0417 Nakamichi, Y. MO0105, SA0477 Author Index

Nakamoto, T. 1258, MO0088, MO0237, MO0264, SA0102, SA0114, SU0108, SU0156, SU0237 Nakamura, H. MO0105 Nakamura, K. 1009, 1011, 1151, 1190, MO0282, MO0385, SA0054, SU0297, SU0378 Nakamura, M. MO0105, MO0247, SU0263 Nakamura, M. C. FR0284 Nakamura, S. 1229, SA0143 Nakamura, T. 1009, 1060, 1201, MO0208, MO0415, SA0096, SA0127, SA0219, SA0412, SA0416, SU0100, SU0211, SU0423 Nakamura, Y. FR0098, SA0098 Nakane, A. MO0266, SA0320 Nakanishi, M. 1155 Nakanishi, Y. FR0044, SA0180, SU0473 Nakano, A. 1229, SA0143 Nakano, M. SA0417 Nakano, T. 1201 Nakao, K. SU0090 Nakashima, K. MO0095 Nakasone, K. SA0266 Nakayachi, M. SU0291 Nakayama, K. MO0300, MO0300 Nakchbandi, I. A. MO0234, SA0138 Nalepa, G. SA0222 Nam, D. MO0070 Nam, H. MO0260 Namatame, Y. SU0325 Namjoshi, M. SU0139 Nanda, R. MO0069 Nandakumar, K. SU0376 Nanes, M. S. MO0243, MO0480 Nango, N. 1161 Naot, D. FR0100, MO0156, MO0211, SA0100, SA0105 Naoyuki, T. MO0299 Napierala, D. 1083, MO0100, MO0107, SA0231 Napoli, N. 1164, SU0409, SU0446 Nardone, V. MO0268 Narine, M. MO0099 Narisawa, S. FR0193, SA0186, SA0193 Naruse, K. SU0319, SU0467 Nastruzzi, C. SU0246 Nasu, A. SU0187 Nauer, R. SU0223 Naughton, G. MO0076, SU0023 Naves-Dı´az, M. SU0176 Nawrot-Wawrzyniak, K. MO0178 Nayak, G. SU0233 Nazarian, A. MO0132 Ndong, J. MO0089 Nebeker, J. SU0342 Neer, R. M. SU0043 Neerup, T. SA0460, SU0324 Neff, K. MO0029 Neff, L. 1047, 1145, MO0272 Nefzi, A. SA0151 Negus, C. H. SA0039, SU0075 Neises, A. 1078 Nelson, C. SA0279 Nelson, J. MO0142 347

Index

Muneta, T. 1197, MO0264 Munivez, E. MO0107, MO0246 Munnich, A. 1018 Munoz-Torres, M. FR0407, SU0332 Munro, R. SU0426 Muntner, P. SU0387, SU0439 Murabito, J. 1165, FR0011, SU0014, SU0372 Murai, T. SA0096 Murakami, M. SA0278 Murakami, S. MO0255 Muraki, S. MO0385, SU0378 Muraoka, R. MO0423 Murata, S. SU0265 Murray, B. Frances SA0161 Murray, M. A. SU0030 Murry, M. FR0059 Murshed, M. SU0233 Murugesh, D. FR0208 Muscara, M. MO0274 Muscariello, R. MO0163 Muschitz, C. 1062, FR0332, FR0418, MO0397, MO0428, SA0043, SA0332, SA0418, SU0333, SU0418 Muschler, G. F. MO0103 Museyko, O. SU0033 Musiał, J. SU0374 Mussano, F. SU0214 Musson, D. SA0100, SA0105 Muthukumaran, P. SU0064, SU0270 Muxı´, A. SA0459 Myers, L. SA0428 Myers, T. 1123, 1126, FR0202, MO0084, SA0202 Myint, K. SA0155 Myoui, A. 1156 Mysling, P. SU0337

Nelson, T. MO0259 Nelson-Filho, P. SU0466 Nenninger, A. 1080 Nervina, J. M. FR0253 Nestlerode, C. SU0197 Nestor, B. SU0210 Netelenbos, C. MO0369, MO0377, SA0377, SA0397 Nethander, M. SA0196, SU0368 Nettlefold, L. MO0021, SU0021 Neumann, D. SU0157 Neumann, H. MO0257 Neutzsky-Wulff, A. SA0298 Nevitt, M. SU0455 Newton, D. SU0152 Newton, E. FR0011 Ng, A. FR0063, SA0063 Ng, P. 1192, MO0296, SA0302 Ngo, R. 1117 Ngui, D. MO0331 Nguyen, D. 1125 Nguyen, J. 1125, SA0083 Nguyen, N. MO0181 Nguyen, N. Dinh 1130, 1259, FR0353, MO0378, MO0402, SA0339, SA0353, SA0375, SU0373 Nguyen, S. C. MO0368 Nguyen, T. 1183 Nguyen, T. V. 1130, 1259, FR0339, FR0353, MO0368, MO0378, MO0402, SA0339, SA0375, SU0369, SU0373 Ni, M. SA0483 Nicholls, F. SU0147 Nicholson, G. 1062, SA0481, SU0012, SU0341 Nicholson, G. C. SU0369, SU0492 Nickelsen, T. N. SA0192 Nickolas, T. L. 1092, 1132, 1202, MO0176, MO0391, SA0048, SA0176, SU0328 Nicks, K. M. 1095 Nico, B. SU0251 Nicola´s Muscara´, M. MO0228 Nicolella, D. SU0048 Nicolella, D. P. SA0064 Nielsen, M. MO0041, SU0337 Nielson, C. M. SA0036 Niemeier, A. C. SA0189, SU0003 Niemi, E. FR0284 Nieves, J. SU0062 Nieves, J. W. 1132, MO0413 Niewolna, M. SA0134 Nifuji, A. MO0095 Niger, C. MO0253 Niida, S. MO0097, MO0322 Nikander, R. Petteri MO0134 Nikkel, L. 1092, MO0176, SU0328 Nilsson, J. FR0020 Nilsson, M. 1179, FR0026, SA0026 Nimmo, J. SA0141 Nino, A. 1211, MO0261, SA0400, SU0046 Ninov, V. MO0148 Nirnberger, G. SU0418 Nisbet, C. SU0027 348

Nishi, H. Nishida, N. Nishida, T. Nishii, Y. Nishikawa, S. Nishimori, S. Nishimura, H. Nishimura, I. Nishimura, R. Nishimura, Y. Nishinakamura, R. Nishisho, T. Nishiwaka, S. Nishiyama, K. Nishizawa, Y. Nishu, K. Nissenson, R. A.

SU0471 1011 FR0090 SU0396 FR0044, SA0180 1194 MO0371 SU0214 1155 SU0471 SA0200 MO0225, SU0150 SU0473 SU0037 1201, SA0416 MO0471 1183, FR0391, MO0241, SA0309 Nitta, K. MO0317 Niu, Q. 1206, 1208, SA0461 Noble, B. S. 1224 Nobuyuki, U. MO0299 Noda, M. 1258, MO0088, MO0237, MO0264, SA0102, SA0114, SA0200, SU0108, SU0156, SU0229, SU0237 Nodelman, M. SU0438 Nogue´s, X. SA0358 Noguchi, H. MO0335 Nogues, X. FR0385, MO0055, MO0131, MO0284, SA0447, SU0140 Nohe, A. 1198, MO0250, SU0200 Nojiri, H. SA0068, SA0266, SU0219 Nomiyama, H. SU0284 Nomura, F. SU0325 Nonaka, K. SU0335 Norman, D. SU0438 Norris, J. 1148, 1222, 1256 Northcutt, A. 1211, MO0261, SA0400, SU0046 Northup, D. SU0157 Notomi, T. 1258, MO0088, MO0237, MO0264, SA0102, SA0114, SU0156, SU0229, SU0237 Novack, D. 1080, SA0024 Novack, D. V. SA0148, SA0303 Novince, C. Michael SA0109 Novotna, D. FR0158 Novotny, S. A. SU0024 Nowson, C. 1166, SU0009 Nozaka, K. SU0360 Nozawa, M. MO0427 Ntzani, E. 1084 Nubbemeyer, R. MO0468 Nuckley, D. SU0024 Nugent, E. MO0082 Nugent, Z. SU0347 Nuti, R. 1062, FR0394, MO0163, MO0337, MO0393, SA0394 Nuutila, P. 1216 Nyman, J. S. 1073, FR0059, MO0079, SA0053, SA0059 Author Index

O

Author Index

349

Index

O Beirne, J. MO0440 O’carroll, D. FR0391, SA0309 O’ Keeffe, L. MO0323 O’brien, C. 1039, 1041, 1110, 1168, 1189, 1209, FR0409, MO0476, SA0487, SU0470 O’brien, R. MO0052 O’brien, S. FR0177 O’brien, T. SA0404 O’carroll, D. MO0241 O’connell, C. SA0184 O’connell, J. SU0367 O’connor, C. 1247 O’donnell, C. FR0383 O’donnell, S. SA0362 O’keefe, R. J. 1219, 1223, SA0129, SA0476 O’loughlin, P. SA0493 O’malley, C. SU0439 O’neill, C. 1018 O’neill, T. 1036, SA0358 O’sullivan, R. SA0256, SU0282 O’sullivan, S. MO0156 Oaklander, A. SU0404 Obayashi, O. MO0427 Oberfield, S. E. 1143, SA0018 Obermayer, B. SA0358 Obermayer-Pietsch, B. M. MO0366, MO0428 Ochi, H. MO0090 Ochi, Y. FR0044, SA0044, SA0180, SU0473 Ochiai, T. SA0127 Ochotny, N. 1016, MO0280 Ode´n, A. MO0358, SA0010, SA0378 Oda, A. SU0298 Oda, K. SU0325 Oda, T. MO0182, SU0407 Oden, A. 1036, 1091, MO0357, SA0328 Odvina, C. V. MO0059 Oei, E. SU0364 Oei, L. 1084, 1142, FR0368, SA0358, SA0368, SU0364 Oelkers, M. SA0274 Oest, M. SU0145 Ofek, O. SU0226 Offerhaus, M. 1142 Offord, E. SA0450 Ofotokun, I. FR0405, SA0405 Ogasawara, T. SA0246 Ogawa, M. 1077 Ogawa, N. SA0183 Oguz, I. FR0072 Oh, C. 1138 Oh, H. SA0390 Oh, J. SA0257, SU0366 Oh, K. SU0366, SU0375 Oh, S. 1075, SU0248 Oh, W. SA0269 Ohashi, Y. SU0423 Ohashi, S. SA0054 Ohba, S. SA0246

Ohlsson, C. 1021, 1084, 1179, FR0026, FR0199, FR0482, MO0198, MO0215, MO0479, SA0010, SA0196, SA0358, SA0378, SU0125, SU0368, SU0483 Ohnishi, I. SA0054 Ohshima, H. MO0415 Ohta, H. SU0423 Ohta, Y. 1195 Ohte, S. 1149, MO0199, SA0244 Ohue, M. MO0417 Ohwada, T. SU0407 Ohya, K. MO0221 Ohyama, M. FR0448 Ojala, K. MO0134 Ojeda, N. SU0395 Oka, H. MO0385, SU0378 Okabe, T. 1195, SA0127 Okamoto, S. MO0335, MO0335 Okamoto, Y. SA0464 Okano, T. MO0449, SU0178 Okawa, A. MO0090 Okayasu, M. SU0291 Okazaki, K. SA0183 Okazaki, M. SA0124 Okazaki, R. MO0423 Okuda, S. SU0407 Okuno, J. SA0016 Okura, T. SA0016 Olabisi, R. Mojoyinola SA0225, SU0040 Olaso, R. SU0188 Oldak, A. SA0076 Olero¨d, G. MO0357, MO0370 Olguin, M. SU0398 Oliveri, B. MO0488, MO0490, SU0344 Olivos, N. 1050 Olmos, C. SA0447 Olmsted-Davis, E. A. MO0108, SU0040 Olson, D. A. 1004 Olson, E. SU0162 Olson, E. N. 1194 Olstad, O. SU0097 Olszynski, W. 1055, MO0008 Omata, Y. 1190, SU0297 Ominsky, M. S. 1070, 1206, 1207, MO0312, SA0058 Omote, K. SU0308 Onal, M. 1039, 1041, FR0409, SA0409 Ong, K. SU0372 Ongkeko, W. SU0141 Onishi, H. SU0069 Ono, K. 1155, MO0089 Ono, M. MO0208, SU0100, SU0110, SU0211, SU0263 Ono, N. SU0087 Ono, T. MO0077 Ooi, L. MO0138 Ooishi, R. SA0278 Oranger, A. SA0149 Orcel, P. MO0189 Orchard, T. MO0373, SU0352 Oren, T. SU0112 Orimo, H. SU0423 Orkin, S. 1154

Orkunoglu-Suer, F. SA0009 Ormaza´bal, C. 1232 Ornelas, R. SU0026 Orozco, L. SA0245 Orr, J. FR0092, SA0092 Orriss, I. SU0222 Orsini, L. SA0249 Orwig, D. L. 1096, MO0374 Orwoll, E. S. 1019, 1066, 1241, MO0343, MO0382, MO0384, MO0442, SA0012, SA0036, SA0173, SA0354, SA0359, SA0388, SU0048, SU0167, SU0348 Osada, H. SA0143 Osagie, L. MO0066 Osaki, M. SA0381 Osdoby, P. A. 1015 Oshima, H. MO0326, SA0329 Oshima, K. SA0178 Ostermann, N. MO0463 Ostertag, A. 1245, SA0403 Ostrowski, M. C. SU0285, SU0288 Osumi, N. SU0263 Ota, K. 1045, MO0277 Otero, J. SU0185 Otsubo, S. MO0317 Otsuka, T. SU0187 Ott, S. SA0352 Ott, S. M. MO0341 Otto, C. MO0468 Ounadjela, S. 1128 Oursler, M. 1045, 1121, MO0277, SA0228 Oury, F. FR0003, SA0003 Outman, R. C. FR0325, SA0434 Ouyang, H. 1090 Owen, C. 1016, MO0280 Oxford, J. RT SU0213 Oyajobi, B. SA0289 Oyama, T. SA0096 Oz, O. K. SA0485, SU0154 Ozaki, S. 1229 Ozcivici, E. FR0067, SA0067 Oze, H. 1156 Ozkayin, N. MO0387 Ozono, K. FR0094, MO0316

P Pan´czyk-Tomaszewska, M. MO0178 Pacifici, M. 1195, SA0127 Pacifici, R. 1116, SA0128 Pack, A. M. MO0332 Padgett, L. MO0116 Paent, S. SA0247 Pagel, C. MO0210 Paggiosi, M. Anne SA0336, SU0058 Pagnotti, G. SU0151 Paige-Robinson, J. Lorraine 1230, FR0311, MO0155 Paigen, B. MO0197 Paik, J. MO0164 Pajevic Divieti, P. 1051, SA0315, SU0152 Palchesko, R. SA0220 Paldanius, P. MO0407 350

Palermo, L.

1248, 1250, MO0408, MO0412, SU0422, SU0428 Pallais, J. 1101 Pallu, S. Arnaud SA0402, SU0068 Palmer, A. SA0443 Palnitkar, S. MO0035, SU0163 Paltrinieri, E. MO0165, SA0172, SU0169 Palva, T. MO0134 Pan, C. SA0245 Pan, H. MO0103 Pan, K. 1133 Panaroni, C. FR0267, SA0267 Panattoni, M. 1008 Panchapakesan, K. SA0009 Panda, S. Prakash 1017 Pandit, K. 1202, SA0415, SU0179, SU0430 Pang, L. 1193 Pang, S. 1117 Panganiban, B. 1025, 1108, SU0045 Panizo, S. SU0176 Papadimitropoulos, M. SU0350 Papaioannou, A. MO0011, MO0328, MO0331, MO0453, SA0357, SA0444, SU0136, SU0380, SU0405 Papanastasiou, P. 1066 Papapoulos, S. 1063, 1065, 1102, MO0309, MO0353, SA0393, SU0191 Papasian, C. 1174 Pare´s, A. MO0232 Pard, R. 1008 Pardi, E. MO0165, SA0172, SU0169 Parham, K. SA0221 Parhami, F. MO0204 Parikh, N. MO0168, SU0163 Parimi, N. 1023, MO0382 Park, B. SA0406 Park, C. Yongjoo SU0469 Park, E. MO0291 Park, H. SA0251, SA0398, SU0424 Park, J. MO0053, SU0424 Park, K. SU0215 Park, M. SA0001 Park, N. MO0087, MO0236 Park, O. SA0288, SU0209 Park, S. 1088, MO0042, SA0139, SU0161, SU0296, SU0433 Park, W. MO0213 Park, Y. MO0379, SA0398 Park-Min, K. SU0289 Parker, K. 1033 Parker, R. 1058 Parkkola, R. 1216 Parsons, G. SU0485 Parthasarathy, R. SU0271 Pasanen, M. SU0011 Paschalis, E. MO0411, SU0035, SU0063 Paschalis, E. P. SU0099 Pasco, J. A. 1036, SA0481, SU0012, SU0341 Passeri, G. SA0149 Passos-Bueno, M. MO0270 Paszty, C. 1208 Patane`, S. SU0134 Patel, M. MO0074 Author Index

Author Index

Peroni, J. SU0040 Perrelet, R. SA0360, SU0357 Perrien, D. S. MO0269 Perrin, N. SA0354 Perry, J. SU0372 Peruzzi, B. 1028, 1089, 1089, SU0216 Perwad, F. MO0115 Peter, K. SU0337 Peter, Q. FR0215 Peters, C. SA0184 Peters, K. 1121, FR0466, MO0202 Petersen, S. MO0161, MO0404, MO0457 Peterson, I. 1264, MO0364 Peterson, R. MO0045 Petit, M. A. MO0071, SU0024 Petros, J. 1230 Pettersson, U. SA0358 Petto, H. 1249, FR0413 Petty, S. SA0404 Pfeilschifter, J. MO0377, SA0377 Pham, H. MO0485 Pham, L. SU0307 Pham, T. 1216, MO0340, SU0016 Philbrick, K. A. 1004, SU0204, SU0206 Philip, B. SU0260 Philippe, C. MO0002, SU0294 Phillips, C. L. SA0111 Phillips, E. SU0066 Phillips, E. Abraham MO0183 Phillips, L. FR0177 Phipps, R. J. MO0411, SU0035 Piacentini, A. MO0230 Piao, J. MO0090 Picci, P. SU0144 Pickard, L. E. MO0011, MO0453, SA0357, SA0444 Pickarski, M. MO0472, SA0473, SU0472 Picone, A. MO0165, SA0172, SU0169 Pieber, T. MO0366, MO0428, SU0055, SU0346 Pienkowski, D. 1057 Pier, D. 1224 Pierroz, D. D. 1191 Pietrini, M. SA0394 Pietrogrande, L. SU0447 Pike, J. Wesley SA0487 Pilbeam, C. C. MO0123, MO0400 Piliciauskiene, R. SA0321 Pillay, I. MO0440 Pilote, L. 1251 Pilotto, R. SA0008 Pilz, R. MO0245, SU0480 Pingel, J. SA0152, SU0105 Pinheiro, M. M. MO0004, SA0343 Pinte´r, C. MO0180 Pirih, F. 1075, 1226 Pirker, T. SU0333 Piro, B. MO0436, SU0432 Pitel, K. 1121, FR0466, MO0202 Piva, R. SU0246 Piwnica-Worms, D. 1086 Plasilova, I. FR0158 Plotkin, L. I. 1035, 1050, 1067 351

Index

Patel, S. SU0442 Paternoster, L. SA0196, SU0368 Paterson, J. SU0431 Paterson, M. SU0436 Patil, C. MO0079 Patil, R. SU0011, SU0254 Patrene, K. 1046 Patrick, A. SA0364, SU0437 Patsch, J. FR0061 Patsch, J. M. FR0049, SA0049 Pauchard, Y. SU0050 Paudel, M. SA0355 Paul, E. 1239, FR0223 Paul, G. 1211, SA0400, SU0046 Pauley, C. MO0046 Pavalko, F. SU0260 Pavelka, T. SU0383 Pavlos, N. MO0301 Pavlos, N. J. 1192, MO0296, MO0300, SA0207, SA0297, SA0302, SU0280 Pavlovic-Surjancev, B. SU0359 Pavo, I. 1249, FR0414 Pawson, T. 1258 Payer, J. MO0329 Pazianas, M. SA0427 Pen˜a, J. FR0413 Peacock, L. FR0157, FR0465 Peacock, M. 1061, MO0023, MO0477, MO0482, SA0119, SA0175, SU0025 Pearsall, R. 1210 Peault, B. SA0104 Peck, V. MO0426 Pedroza, C. SU0450 Peele, A. SA0057 Peercy, B. SU0495 Peichl, P. 1199 Pejda, S. 1005, SA0237 Pekkarinen, T. SU0451 Pekkinen, M. H. 1180 Pellegrini, G. 1050, 1067 Pelletier, J. 1150, FR0233 Pena, C. 1115 Peng, J. 1018 Peng, X. 1013, SA0134 Peng, Y. MO0235 Peng, Z. SA0460, SU0042, SU0324 Pennisi, A. MO0145 Penny, I. SU0330 Pennypacker, B. L. 1030, MO0472, SA0473 Penolazzi, L. SU0246 Pentyala, S. SU0117 Pepe, I. SU0446 Pepe, J. MO0372, SA0008 Pereira, F. A. MO0167 Pereira, R. C SU0318 Pereira, R. M R MO0363, SU0362 Pereiro, I. SA0101 Perera, S. MO0142, SU0007, SU0382 Pereverzev, A. FR0252 Perez-Cano, R. SU0397 Perez-Edo, L. MO0284 Peris, P. 1076, FR0066, MO0232, SA0459 Perocheau, D. 1159

Ploutz-Snyder, R. Pluskiewicz, W. Podani, J. Poiana, C. Poinas, A. Poliard, A. M. Poliquin, S. Pollak, M. Pollock, M. Pollock, N. K.

MO0415 SU0343 MO0180 SA0422 SU0329 MO0100 SU0350 1052 MO0345 1177, MO0482, MO0483, SU0028 Pols, H. A.P. SA0368 Pompolo, S. 1048 Poncell, M. SA0162 Poole, K. ES 1127, MO0333, SU0158 Pop, C. MO0396 Popa, N. MO0207 Popim, R. MO0362 Popoff, S. N. FR0291 Popp, A. W. SA0035, SA0360, SU0357 Porta, A. R. SU0487 Portal, S. MO0007 Portal-Nu´n˜ez, S. SU0203 Portale, A. A. MO0115 Portela, M. SU0398 Portell, E. FR0066 Porteous, F. MO0156 Porter, D. 1057 Portero-Muzy, N. MO0403, MO0464 Portole´s, M. SU0203 Pote, S. MO0265 Potenziani, S. SU0271 Potter, R. SA0064 Potts, J. T. SA0124 Pouliot, L. SA0022 Poulton, I. 1048 Poundarik, A. A. 1103 Pourteymoor, S. 1178 Poushanchi, B. SU0155 Powell, D. 1172 Pozuelo, J. SA0308 Pozzilli, P. SU0409 Prairie, B. 1093 Prasad, J. SA0007 Prati, C. SU0259 Preisinger, E. MO0016 Preisser, J. 1059 Premaor, M. O. 1058, MO0377 Presle, N. SU0068 Prezelj, J. MO0438 Price, H. SU0031 Price, J. S. MO0215 Price, R. I. SA0033, SA0033 Prieto-Alhambra, D. FR0385, MO0055, MO0131, MO0284, SA0385, SA0447, SU0140 Primakova, I. SU0047 Prince, R. L. 1163, MO0345, SA0033, SA0358 Prinz, C. MO0257 Prior, J. 1036, 1086 Prior, J. C. 1055, SU0190, SU0350, SU0370 Prisby, R. D. MO0410, SU0417 Pritchard, J. M. SU0405 352

Pritzker, K. Proctor, A. Przedlacki, J. Puel, c. Puig, A. Purcell, E. Purcell, M. Purdue, E. Purton, L. Putman, M. Putney, J. Puzas, J.

MO0416 MO0048 SU0374 SA0458 SA0494 FR0116, MO0114, SA0116 MO0037 SU0210 MO0154, SU0148 SU0043 SU0290 SU0245, SU0253

Q Qanie, D. Qian, A. Qin, A. Qin, L.

SU0242 MO0218 MO0301, SA0302 1026, 1027, FR0079, MO0092, MO0129, SA0471, SU0217, SU0464 Qin, Y. MO0065, MO0075, SU0060, SU0067, SU0339, SU0393 Qing, H. SU0393 Qiu, D. SU0118 Qiu, J. SU0315 Qiu, S. MO0035, SU0163 Qiu, T. 1193 Qiu, X. 1189, MO0235 Qiwei, S. MO0196 Qu, C. 1229 Qu, S. MO0179, MO0450 Quach, J. MO0154 Quach, L. MO0352 Qualls, C. 1164 Queiroz, R. MO0344, SA0361, SU0345 Quesada Gomez, J. SU0261 Quinlan, J. MO0440 Quinonez, D. SU0184 Quint, P. 1045, MO0277, SA0228 Quintana, R. SA0153

R Ra¨isa¨nen, J. 1216 Rabbitt, E. SA0480 Rabelink, N. SA0397 Rademaker, A. SU0031 Radmer, S. SA0435, SU0454 Radominski, S. 1065 Ragi Eis, S. 1062 Rahman, M. Mizanur MO0471 Rahman, S. 1227 Raices, R. MO0140 Raimondo, E. SU0447 Raisch, D. FR0423 Raitakari, O. 1084, SA0196, SU0020, SU0368 Rajamannan, N. M. 1121, MO0202, SU0186 Rajapakse, C. S. MO0183 Ralphs, D. SA0227 Ralston, S. H. 1082, SA0358, SU0165, SU0369 Author Index

Author Index

Rejnmark, L.

1098, MO0171, SA0169, SU0488 Rekedal, L. SU0437 Rendina, D. MO0163 Rendina, E. SA0399, SU0399 Rendl, S. SU0435 Renner, J. 1171 Renner, W. MO0366 Repeke, C. MO0203 Repic, D. 1005, SA0237 Replogle, R. SU0199 Reppe, S. SU0097 Resch, H. 1065, FR0332, FR0418, FR0453, MO0397, SA0043, SU0333, SU0418 Research Group, C. 1055 Resnick, N. MO0142, SU0007, SU0382 Restaino, S. SU0430 Rettew, A. SA0154 Revicki, D. SU0455 Revollo, L. Denise 1148 Reyes, R. FR0407 Reyes-Garcı´a, R. SU0332 Reynolds, J. C. SU0123 Reynolds, K. SU0439 Rhee, Y. SA0406, SU0379, SU0406 Rhodes, S. 1186 Rhodes, S. D. 1013, SA0222 Riancho, J. A. MO0224, SA0358 Rianon, N. J. SU0450 Ribeiro Barros, E. FR0195 Rice, B. MO0148 Richards, B. 1084, FR0199, FR0367, FR0384, SA0358, SU0369, SU0372 Richards, R. SA0035 Richards, W. 1206, FR0206 Richardson, J. SU0017 Richardson, S. SA0141 Richardson, Y. SA0221 Richter, J. SA0298, SU0299 Riddle, R. C. 1001 Ridker, P. 1084, SA0358 Ridout, R. SA0420 Rieger, R. MO0062 Riekkinen, O. MO0339 Riera-Espinoza, G. MO0360 Ries, W. L. MO0150 Rietbergen, B. Van SA0337 Riggs, B. Lawrence 1095, 1176 Rijzewijk, L. MO0309 Rikkonen, T. MO0375 Rinaldi, E. SA0149 Ringe, J. MO0445, SA0192 Rini, G. SU0446 Riquelme, M. SA0479, SU0310 Rissanen, J. SA0460, SU0042 Rissanen, J. P. SA0142, SU0324 Ritchie, R. 1025, 1108, SA0034, SU0045, SU0049 Ritter, C. SA0123, SU0493 Rittling, S. R. SA0114 Rittweger, J. MO0160, SU0078 353

Index

Ramachandran, V. FR0078 Ramakrishnan, P. MO0469 Ramautar, S. MO0353 Ramirez, S. SU0194 Ramos, A. MO0167 Ramos, J. MO0360 Rampakakis, E. MO0421, SA0429 Ranch, D. MO0115 Randall, C. MO0055 Randall, R. SU0089 Ranganath, L. SU0107 Rangaswami, H. MO0245, SU0480 Rankin, E. 1154 Ransom, J. MO0170, SA0170 Rantalainen, T. MO0047 Rao, D. 1203, MO0035 Rao, L. G. MO0448 Rao, S. MO0059, MO0168, MO0174, SA0164, SU0163 Rao, V. MO0448 Rashid, H. SA0231 Raska, I. SA0326 Raspini, B. MO0165, SA0172, SU0169 Rasums, A. MO0409 Ratner, L. 1092, SU0328 Rauch, A. 1109 Rauch, F. 1083, FR0030, MO0193, SA0019, SU0032 Rauma, P. MO0376 Rauner, M. 1074, 1207, FR0255, SA0185, SA0255 Raychaudhuri, S. SU0366 Raz, R. 1120 Raza, K. SA0480 Razidlo, D. 1152, FR0086 Razmpour, R. FR0291 Reams, R. SU0461 Recker, R. 1203 Recker, R. R. 1200, 1202, FR0492, MO0318, MO0391, SA0060, SA0415, SA0430, SU0414, SU0421 Recknor, C. 1062, FR0446 Recknor, C. P. 1203 Reda, A. MO0436, SU0432 Redden, D. FR0325 Reddy, A. MO0113, SU0183 Reddy, S. V. MO0150, SA0164 Reeve, J. 1084, SA0358 Reeves, A. SU0032 Reginster, J. 1065, 1066, MO0442 Reich, A. SU0189 Reichenberger, E. FR0190 Reichenberger, E. J. MO0159, MO0187, SU0269 Reid, D. M. 1036, MO0031, MO0447, SA0457, SU0381 Reid, I. R. 1248, MO0211, MO0424, SU0422, SU0428 Reider, L. 1096 Reina, P. SU0078 Reis, R. Luz SA0162 Reisinger, A. FR0413 Reitz, R. E. SU0484

Rivadeneira, F. 1036, 1084, 1142, 1165, FR0367, SA0358, SA0368, SU0198, SU0364, SU0367, SU0372 Rivera, M. SA0152 Rix, M. FR0325, SA0354 Rizzi, R. SA0149 Rizzoli, R. 1066, MO0380, SA0056, SA0393, SU0441 Roato, I. SU0134 Robbins, J. A. SU0367 Roberson, P. SU0470 Roberts, B. SA0038 Roberts, S. John SA0262 Robey, P. G. MO0114, SA0116 Robins, S. P. SU0035 Robinson, A. SU0389 Robinson, B. FR0325 Robinson, J. FR0095 Robinson, K. MO0017, MO0018, SA0022 Robinson, M. SU0148 Roblin, D. FR0325, MO0432 Robling, A. G. 1035, 1067, SA0222, SU0127, SU0260 Rocek, M. FR0158 Rochcongar, P. MO0076 Rochefort, G. Y. MO0043, SA0402 Rodd, C. 1140, FR0030, MO0340, SA0019, SA0021, SU0016 Rodenberg, E. J. MO0108 Rodova, M. MO0220 Rodrigues Guimara˜es, M. MO0228 Rodriguez, J. FR0074 Rodriguez-Portales, J. FR0453 Roeder, R. MO0196 Roessler, B. SA0179 Roffe, C. SU0457 Roforth, M. SA0239 Roger, T. MO0078 Rogers, K. FR0405 Rogers, M. SA0303 Rogers, M. J. SA0300, SU0272 Roldan, E. J.a. SU0164 Rolighed, L. 1098, 1173, SA0169 Roma´n Ivorra, J. 1065 Roma´n-Garcı´a, P. SU0176 Romagnoli, C. MO0226 Romagnoli, E. MO0372, SA0008 Romas, E. MO0209 Romeo, J. SA0220 Romero, G. SU0124 Romero-Suarez, S. FR0005, SA0005, SU0001 Romijn, J. MO0309 Ronis, M. MO0262, SA0023 Roodman, G. 1046, 1090, 1184, FR0165, FR0166, SA0155, SA0156, SU0490 Root, S. MO0287 Roper, P. SU0223 Ros, M. 1160 Rosa, A. MO0344, SA0361 Rosales, A. FR0325, SA0354 Roschger, A. SU0035 354

Roschger, P.

MO0158, MO0178, SA0058, SU0035, SU0063 Rose, E. MO0437 Rose, K. 1082 Rose, L. 1082, 1084 Rosen, C. J. 1034, 1193, 1196, 1213, 1227, MO0222, MO0391, MO0408, SA0415, SU0005 Rosen, V. 1120, MO0200, SA0201 Rosenbaum, P. SU0080 Rosenberg, E. FR0453 Rosengren, B. E. 1264, FR0020, MO0364 Roser-Page, S. FR0405 Rosete, F. SU0340 Roshan, A. SU0114 Rosmalen, F. SU0485, SU0486 Rosol, T. J. MO0119, SA0109 Ross, F. SU0210 Ross, R. SA0300 Rossa Junior, C. MO0228 Rossi, M. SU0278 Rossini, M. MO0377, SA0377 Roth, H. MO0455 Rothe, L. 1015 Rothmann, M. SU0444 Rottner, K. SA0274 Rousch, S. SA0234 Rousseau, F. FR0367, SA0358 Rousseau, J. MO0320, SU0113 Roux, C. 1063, 1065, FR0439, FR0446, MO0377, SA0377, SU0381 Roux, J. SU0388 Roux, S. MO0355 Rowe, B. 1136 Rowe, D. W. 1005, 1073, 1228, FR0312, MO0086, MO0256, SA0258, SU0269 Rowe, G. 1003 Rowe, P. Stanley SA0144, SU0120 Rowland, B. MO0045 Rowland, M. SA0225 Royals, T. SU0395 Rozas-Moreno, P. FR0407, SU0332 Rozeman, L. SU0144 Ruan, Z. Merry SU0081 Rubin, C. T. FR0072, MO0065, SA0046, SU0151, SU0207, SU0264 Rubin, J. 1171, 1240, FR0072, MO0255, SU0074 Rubin, M. R. 1097, MO0172, MO0261, MO0414 Ruby, J. SA0009 Rucci, N. 1028, 1089, SU0216 Ruether, W. SA0189 Ruff, A. SA0317 Ruff, V. 1203, 1204 Rufo, A. 1089 Ruh, C. SA0103, SU0047 Ruiz-Gaspa`, S. MO0232 Rumpler, M. SU0099 Rundek, T. 1099, SA0168 Rundle, C. H. MO0207, SA0015 Runge, M. MO0103, MO0455, SA0017 Ruppender, N. SA0140 Author Index

Ruppert, K. Ruppert, L. Russell, A. Russell, G. Russell, S. Russell, W. Russo, S. Rutkowski, J. Ruvio, M. Ryan, J. Ryan, S. Ryan, T. Rychly, J. Ryhl Plovst, J. Ryoo, H. Ryu, E.

1093, SU0336 SA0338 1136 SA0427 FR0312 SA0300 MO0372, SA0008 SA0220 SA0394 SA0184 1124, FR0177 MO0020 MO0257 MO0161 FR0187, SU0201 SU0170

S

Author Index

1114, SA0477, SU0477 MO0097 SU0396 MO0324 SU0108, SU0156 SA0241 1148, 1222, 1256 MO0072, MO0465, SA0039 SA0436 MO0108 FR0182 SU0318 1030, MO0017, MO0018, SA0022, SU0083 Samaras, A. FR0423 Sambandam, Y. MO0150 Sambrook, P. N. 1024, MO0369, MO0377, SA0377 Samelson, E. J. FR0383, SA0383, SU0036 Sami, S. 1183 Sammut, B. FR0165, SA0156 Sampalis, J. FR0429, MO0421, SA0429 Sampson, E. R. 1223 Samuels, D. SA0338 Samuels, M. MO0384 Sanders, K. M. 1166, SU0492 Sanderson, P. SU0097 Sanganee, H. FR0475 Sanjay, A. SA0305 Santa Maria, C. 1146, MO0085 Santiago-Mora, R. SU0261 Santora, A. C. SA0354 Santos Pinto, D. MO0390, SU0440 Santos, M. MO0344, SA0361, SU0345 Santosh, S. SU0389 Sapkota, B. 1011 Saponaro, F. MO0165, SA0172, SU0169 Sarafin, K. FR0384 Sardesai, S. SU0066 Sarfati, E. SA0167 Sarhaddi, D. SU0155 Sarkis, K. SA0343 Sarkissian, A. SU0448 Sarrion, P. MO0284 Sasaki, M. MO0315 Sasaki, S. SU0419 Sasaki, Y. SU0335 Sasanuma, H. 1149, MO0199, SA0244 Sasseville, M. 1187 Sathisha, U. MO0145 Sato, K. 1003 Sato, M. SU0130, SU0247 Sato, N. SU0085 Sato, T. 1054, SU0291 Satoh, S. MO0317 Sattar, N. MO0025 Satterfield, S. 1212 Saturnino, L. MO0051 Saunders, F. R. MO0031 Sawka, A. MO0453 Sawyer, R. SA0493 Saxon, L. K. MO0215 Sayegh, M. MO0475 355

Index

S´wirski, A. SU0374 Sa¨vendahl, L. FR0482, SA0491 Se´guin, C. MO0475, SU0184 Se´ve`re, N. MO0152 San˜udo, C. MO0224 Saag, K. MO0432 Saag, K. G. 1246, 1247, FR0325, FR0433, FR0439, MO0377, MO0419, MO0429, MO0439, MO0452, SA0377, SA0434, SA0441, SA0444, SU0326, SU0427 Saarnio, E. M. 1180 Saarto, T. MO0134 Saavedra, P. SA0340 Sabbag, T. MO0344 Sabbagh, Y. 1124, FR0177, SA0177 Sabokbar, A. SU0180 Sacco, R. 1099, SA0168 Sacco, S. M. SA0469, SU0481 Saccone, M. MO0351 Sachse, D. SU0097 Sacks, F. SU0400 Sacks, H. SU0468 Sadka Rosenberg, Z. MO0426 Sadler, C. 1164 Sadler, W. 1088 Saeed, I. MO0036, SA0400 Safadi, F. F. FR0291 Safford, M. FR0325, SU0387 Sage, A. SU0183 Saha, P. MO0046 Sahlberg, B. SU0474 Sahni, S. MO0348, MO0352 Saidak, Z. SU0476 Saini, V. 1051, SU0152 Sainsbury, A. 1002, MO0233 Saita, Y. MO0427, SA0068, SA0114, SA0266, SU0219 Saito, A. MO0278 Saito, H. 1003, 1047, 1145, FR0131, MO0006, SA0477 Saito, M. SU0219 Saito, T. 1009, 1011, 1151 Sakai, A. SA0096, SA0219 Sakai, K. MO0427

Sakai, S. Sakai, Y. Sakata, S. Sakuishi, T. Sakuma, T. Salazar, D. Salazar, V. Sale, C. Sale, J. Salisbury, E. Salminen, S. Salusky, I. B. Samadfam, R.

Sayers, A.

1141, MO0025, MO0160, SA0196, SU0022, SU0368 Sbardella, E. MO0372 Scadden, D. T. 1037 Scanlan, T. MO0270 Scarpiello, A. MO0372, SA0008 Scerpella, T. A. SU0080 Schu¨ler, C. MO0468 Schacht, E. MO0455 Schafer, A. L. 1250, MO0412, SU0422 Schaffler, M. B. 1105, SU0038 Schaible, E. SA0034 Scher, J. SA0420 Schett, G. SU0033 Schiavi, S. C. 1124, FR0177 Schiffhauer, L. 1233 Schill, A. 1106 Schindeler, A. FR0157, SA0157 Schindler, E. SU0043 Schipani, E. 1154 Schiuma, D. SA0035 Schkoldow, J. MO0468 Schleyer, P. FR0419, MO0422 Schlezinger, J. SA0241 Schlieve, C. 1183 Schlussel, Y. MO0396 Schmidt, J. SU0160 Schmieder, A. SA0071 Schmitz, J. MO0381 Schmushkovich, I. SA0006 Schnaser, E. MO0255 Schneider Herrera, B. MO0228 Schneider, J. Georg 1086, SA0303 Schneider, M. SA0022 Schneider, P. SU0435 Schnitzer, T. J. SA0338 Schober, H. MO0130, SA0435, SU0454 Schoenmaker, T. MO0289 Scholes, D. MO0341, SA0352 Scholten, D. SA0087 Schoppet, M. MO0401 Schousboe, J. T. 1241, SA0355 Schreier, L. SU0398 Schroeder, G. MO0130 Schrooten, J. SA0262 Schrope, B. SU0179 Schutte, L. MO0294 Schutz, H. SA0076 Schwab, P. SA0360, SU0357 Schwappacher, R. MO0245 Schwarcz, H. SU0405 Schwartz, A. V. 1212, FR0061, MO0347, MO0408, SA0049, SA0388, SU0422, SU0450 Schwartz, M. A. FR0073 Schwarz, E. M. SA0129, SA0476 Schwarz, P. MO0404, MO0457, SU0222, SU0494 Schweitzer, D. SA0397 Schwetz, V. MO0366 Schwiedrzik, J. SU0056 Scialdoni, A. MO0051 Scibora, L. M. MO0071 Scillitani, A. SA0174 356

Scozzari, F. Scudiero, D. Sculco, T. Seawright, E. Sebo, T. Secombes, K. Sedig, S. Seefried, L. Seehra, J. S. Seeman, E. 1064, 1129, MO0014,

SU0446 SU0152 SU0210 MO0109 MO0405 SA0457 SU0474 MO0001 1210 MO0334, SU0334 Seeman, T. SA0350 Segal, E. SU0438 Segantin, A. SU0345 Segantin, B. MO0344, SA0361, SU0345 Segawa, H. MO0126, MO0128, SA0118, SA0124 Segawa, T. SU0475 Seibel, M. SA0443 Seibel, M. J. 1109, MO0138, MO0139, MO0402, SA0136, SU0142 Seidah, N. SU0005 Seidlova-Wuttke, D. SU0004 Seifert-Klauss, V. SU0190 Seiji, K. MO0473 Seijo, M. MO0488, MO0490 Seino, S. SU0256 Seki, A. SA0462, SU0465 Sekiguchi-Ueda, S. MO0324, SA0324, SU0119 Sekiya, I. 1197, MO0264 Selby, P. SU0165 Selby, P. L. MO0169 Selhub, J. MO0348 Selig, S. MO0014 Selim, A. Abdulwahed SA0113, SU0174 Sellmeyer, D. E. 1250, MO0412 Sen, B. 1240, FR0072, SA0072, SU0074 Sena, K. MO0458, MO0462 Seng, V. SU0132 Senn, C. SA0360, SU0357 Senussi, I. MO0098, SU0098 Seo, E. SA0345 Seo, Y. SA0276 Seppa¨nen, J. SA0142 Sereinigg, M. SU0055 Serell, S. SA0038 Seres, Z. SU0457 Sernia, C. SU0252 Serra, J. SA0101 Serra, M. SU0466 Serra, R. A. SA0110, SU0094 Serra-Hsu, F. SU0060, SU0339 Serrano, M. SU0203 Servitja, S. MO0131, SU0140 Seselj, M. 1144, FR0052, SA0052 Seth, T. SU0489 Seton, M. MO0191 Setty, N. MO0342 Seunghyun, K. SU0363 Seuwen, K. MO0307 Sevick, E. SU0040 Sezak, M. MO0387 Author Index

Shackelford, L. Shafer, M. Shaffer, A. D. Shah, J. Shah, K. Shah, M. Shah, P. Shah, S. Shahnazari, M.

Author Index

Sheu, T. SU0245, SU0253 Sheu, Y. MO0347, SA0012, SA0388 Shi, J. MO0114, SA0116 Shi, K. 1156, SA0178 Shi, Q. MO0298 Shi, X. 1107, MO0258, SA0213, SU0266 Shi, Y. SA0135, SU0235 Shi, Z. 1188, FR0290, MO0293, SA0272 Shibata, M. MO0324, SA0324, SU0119 Shieh, A. 1137 Shields, P. MO0409 Shimada, A. MO0095 Shimada, Y. MO0359, MO0444, SA0426, SU0419, SU0475 Shimizu, A. SA0121 Shimizu, T. SA0068, SA0266, SU0219 Shimizu, Y. MO0077, MO0117 Shin, C. FR0392, SA0269, SA0376, SU0296, SU0386, SU0424 Shin, G. SA0294 Shin, M. 1149, MO0199, SA0244 Shin, N. 1047 Shin, Y. MO0053, SU0429 Shinagawa, Y. SA0464 Shinoda, H. SU0293 Shinohara, K. MO0103 Shinohara, M. MO0303, SA0232 Shintani, S. MO0473 Shioda, T. FR0131 Shiozaki, M. MO0050, SA0065 Shiraki, M. 1201, SA0412, SA0416, SU0423 Shirazi-Fard, Y. 1238, MO0149, SA0040 Shitoto, K. MO0427 Shively, J. SU0227 Shoback, D. 1049, 1053, 1146, 1250 Shoemaker, R. SU0152 Shogren, K. MO0151 Shonuga, O. MO0461 Shore, E. M. SU0095 Shrank, W. SU0437 Shrestha, L. SU0195 Shrestha, S. SA0036 Shroyer, K. SU0151 Shu, B. 1223 Shu, L. 1233, MO0141 Shu, T. MO0235 Shugg, R. P. MO0304 Shuldiner, A. SA0197 Shults, J. SA0029 Shunmoogum, S. SA0247 Shunsuke, U. MO0299 Sibonga, J. MO0415 Siclari, V. A. MO0092, MO0129 Siddique, M. FR0419, MO0422 Siddique, N. SU0415 Siervogel, R. 1144, SA0052 Siervogel, R. M. MO0195, SA0342, SA0379 Sietsema, D. SA0087, SA0097 Sieva¨nen, H. SU0011, SU0020 Sievanen, H. MO0134 Sif, S. SU0489 Siffert, R. SU0340 357

Index

MO0415 MO0398 MO0461 SU0152 1164 1215 SU0235 SU0259 SA0260, SA0467, SU0045, SU0267 Shaker, J. L. SU0162 Sham, P. 1084, MO0198 Shamonki, J. MO0153 Shane, E. 1092, 1132, 1200, 1202, MO0044, MO0176, MO0332, MO0391, MO0413, SA0047, SA0048, SA0176, SA0415, SU0179, SU0327, SU0328, SU0340, SU0371, SU0414, SU0430 Shang, P. MO0218 Shankar, K. MO0262, SA0023 Shanmugarajan, S. SA0164 Shannon, J. MO0343 Shao, J. FR0160, SA0160 Shao, N. SU0217 Shao, Y. SU0089 Shao, Y. Y. SA0089 Shapiro, J. MO0415 Shapses, S. MO0396, SU0028 Sharma, A. SU0016 Sharma, L. SU0285 Sharma, N. 1169 Sharma, R. SA0408 Sharma, S. MO0174 Sharma, S. Mangalore SU0285, SU0288 Shattil, S. MO0245 Shaughnessy, J. MO0145 Shaul, P. SU0470 Shaw, A. SA0201 Shaw, C. MO0020, MO0100 Shaw, N. SA0024 Shawron, K. SU0399 Shchebet, A. MO0263 Sheehy, T. SA0184 Shefelbine, S. SU0049 Shelton, R. 1168, 1189, FR0002, SU0470 Shen, C. SA0470 Shen, H. MO0365, SA0197 Shen, J. 1117, 1223 Shen, K. SU0232 Shen, L. MO0206 Shen, Y. SA0229 Sheng, H. MO0179, MO0450, SU0408 Sheng, M. H. 1038, 1071, FR0319 Shenouda, N. FR0030, SA0019 Shepherd, J. A. 1143, SU0008 Sherk, K. SU0065 Sherk, V. D. SU0034, SU0065, SU0453 Sherman, A. SU0495 Sherwood, R. 1144, SA0052 Sherwood, R. J. SA0379 Shestakova, M. SA0006 Shet, K. MO0408 Sheth, A. FR0405

Siggeirsdottir, K.

1084, MO0408, SA0382, SU0356 Sigurdsson, G. MO0408, SA0382 Sigurdsson, S. MO0408, SU0356 Sikjaer, T. 1098, MO0171, SA0169 Silva, A. SA0346 Silva, B. Campolina Carvalho 1205, 1231, SA0217 Silva, L. SU0466 Silva, M. 1235, SA0071 Silva, O. SA0346 Silva, R. SU0466 Silva, R. Assed Bezerra MO0290, SU0466 Silveira, E. MO0203 Silveira, F. MO0061, SA0396 Silver, T. SU0152 Silverberg, S. 1099, SA0168, SU0166 Silverberg, S. J. SA0018, SU0179 Silverman, S. L. 1024, FR0439, MO0369, MO0377, SA0377, SA0444, SA0456, SU0439, SU0455 Sima˜o, A. MO0081 Simo˜es, V. MO0390, SU0440 Sim, M. MO0153 Simao, A. Sper MO0102, SU0109 Siminoski, K. 1136, FR0030, SA0019 Simmons, J. MO0381 Simon, J. 1062 Simonelli, C. MO0434 Simons, A. SU0101 Simonsick, E. SU0008 Simpson, C. MO0192 Simpson, J. SU0492 Simpson, L. SU0040 Sims, N. A. 1048, 1257, MO0209, MO0210, SA0230, SA0298 Sims, S. FR0252, MO0101, MO0304, SA0273 Sinacore, D. 1164 Sinacore, J. SA0428 Sinaki, M. MO0016 Sinder, B. 1185, SA0109 Singbrant, S. MO0209 Singer, F. R. MO0153 Singh, H. SU0453 Singh, R. MO0019, MO0188 Singhal, V. 1167 Sinha, K. M. SA0231 Sipila¨, S. MO0047 Siris, E. S. FR0439, MO0377, SA0377, SU0455 Sirola, J. MO0375 Siu, R. K. 1117, FR0088, SA0088 Siwila-Sackman, E. MO0120, SU0404 Sjo¨gren, K. MO0215 Sjogren, K. SU0483 Skalova, S. MO0028 Skarantavos, G. N. SA0452 Skidmore, C. MO0351 Skinner, R. SU0146 Slørdahl, K. SA0369 Slater, H. MO0029, SU0030 Slatkovska, L. SU0338 358

Sliney Jr, J. 1097, MO0172, MO0414 Slinin, Y. 1023 Sloan, D. SA0227 Sloane, R. SU0385 Slone, S. SU0271 Small, M. 1135, FR0448, FR0449 Smerdel-Ramoya, A. 1253 Smit, J. MO0309 Smith, B. J. SA0399, SU0399 Smith, E. SU0018 Smith, J. SU0453 Smith, J. N. SU0212 Smith, M. MO0283 Smith, S. 1030, MO0006, MO0017, MO0018, MO0029, MO0415, SA0022, SA0103, SU0047, SU0083, SU0400 Smith, U. SA0378 Smith, W. 1246, MO0419 Smith, Y. SU0226 Snellman, G. SU0354 Snyder, B. D. MO0132 Sode, M. MO0049, SU0077 Soe, K. SA0271, SU0401 Sogabe, N. MO0190 Soki, F. 1088 Soki, F. Naomi FR0139, SA0139 Solah, V. MO0345 Solban, N. 1145, 1210 Solimeo, S. MO0432 Solla, E. SA0101 Solomon, D. H. SU0431, SU0437 Solomon, S. MO0227, SA0226 Somayajula, S. MO0037 Somoza, J. MO0488, MO0490 Son, H. SU0248, SU0366 Son, M. MO0213 Sone, T. 1201, SA0416 Song, C. SU0377 Song, F. MO0085 Song, H. 1138, FR0095 Song, J. FR0392, SA0269 Song, L. MO0126 Song, W. 1124 Sonnet, C. MO0108, SU0040 Soo, C. 1117, FR0088, FR0211, SA0104 Sood, R. FR0095 Soong, C. SU0172 Soong, R. MO0042 Sorel, H. 1234 Sorice, S. MO0204 Sornay-Rendu, E. SA0041, SA0047, SU0057, SU0388 Sosa-Henriquez, M. SA0340 Sottilo, J. MO0381 Souberbielle, J. SA0167, SU0171 Soucek, O. FR0158, SA0158 Soudry, M. SU0438 Souidi, M. SA0348 Soung, D. Yu MO0469 Sousa, D. M. 1002, MO0233 Souza, P. MO0271, MO0275 Sowa, H. SA0442, SU0412 Sowers, M. 1093 Author Index

1123, 1126, MO0084, SA0202 SA0352 1069, SA0315, SU0076 FR0311, SA0311 SA0149 MO0415 1084, FR0449, SA0358, SU0369, SU0372 Speer, G. MO0180 Spelsberg, T. C. 1121, FR0466, MO0202 Spera, M. MO0030 Spevak, L. SA0084 Spindler, M. 1183 Spinner, R. SA0017 Spiros, K. MO0122 Spizter, S. SU0099 Spolidorio, L. MO0228, MO0274 Sprague, E. FR0073 Spray, D. MO0064 Squarzoni, S. SU0084 Squire, M. E. MO0068 Srikanthan, P. MO0039 Srinivasan, S. SU0070, SU0228 Srivastava, R. MO0265 Srivastva, A. 1221 Sroga, G. SA0082 Srour, E. SU0304 St-Arnaud, R. 1113, SU0118 Staal, B. SA0087 Staal, J. SA0335 Staines, K. Ann SU0092 Stains, J. P. MO0253 Stampa, B. SA0334 Stanford, W. L. SA0261 Stankiewicz, J. MO0068 Stanton, R. MO0248 Stathopoulos, K. SA0452 Ste-Marie, L. 1260, SA0430 Stea, S. SU0084 Stec, B. SA0186 Steck, S. 1139 Steel, S. MO0160 Steel, S. A. SU0158 Steen, G. SU0331 Steensma, M. Richard SA0145 Stefan, C. SA0422 Steffes, M. 1023, MO0382 Steiger, P. SA0334 Stein Merkin, S. SA0350 Stein, E. Margaret 1132, 1200, 1202, MO0044, MO0176, MO0391, SA0047, SA0048, SA0176, SA0415, SU0179, SU0340, SU0371, SU0414, SU0430 Stein, G. S. 1217, FR0312, MO0240, SA0146, SA0224, SA0236, SA0242 Stein, J. 1217, FR0312, MO0240, SA0146, SA0224, SA0236, SA0242 Stein, M. SA0234 Stein, N. FR0255 Stein, R. FR0030, SA0019 Stemig, M. SA0263 Stensgard, B. FR0086 Stepan, J. J. 1127, 1249, FR0414, SA0414

Stephens, S. SA0274 Stephure, D. FR0030, SA0019 Sterling, J. A. SA0132, SA0140 Stern, A. Rath MO0313, SU0258 Stern, B. MO0409 Stern, M. M. MO0313, SU0258 Stern, P. H. SU0482 Stewart, P. SA0480 Stice, S. SU0040 Stiegler, P. SA0424, SU0055 Stine, K. SU0146 Stock, J. L. SA0417 Stockmans, I. SU0135 Stoecker, B. J. SA0399 Stoeva, S. MO0009 Stokes, N. SA0027 Stolakis, K. MO0393, SA0394 Stolina, M. 1069, 1080, 1206, 1208, MO0312, SU0267 Stolk, L. SU0372 Stoll, D. MO0162 Stolshek, B. MO0429, SU0443 Stone, K. L. SU0448 Stoner, K. MO0066 Stover, M. MO0159, SU0269 Stover, S. MO0059 Strahm, L. SA0360, SU0357 Stralberg, F. MO0271 Stranahan, A. 1177 Stratford, P. SA0333 Stratton-Loeffler, M. SU0458 Straub, I. MO0489 Strazzullo, P. MO0163 Strbenac, D. SU0148 Streeper, T. SA0400 Streeten, E. A. FR0199, SA0197, SU0194, SU0367 Streff, L. SA0338 Streicher, C. MO0399, SA0120 Streym Thomsen, S. SU0488 Strid, P. MO0196 Strigoli, D. SA0159 Strollo, R. SU0409 Strotmeyer, E. S. 1212, SU0008 Stroud, J. MO0453 Stuart, A. SU0492 Stuart, L. SA0389 Stubbs, J. MO0118 Stubelius, A. MO0479 Study Group, T. MO0254 Stuible, M. 1187 Sturmer, A. MO0409 Styner, M. 1240, FR0072, SU0074 Styrkarsdottir, U. SA0358, SU0366, SU0367 Su, G. 1066 Su, X. FR0303, SA0303 Suadicani, S. MO0064 Subik, K. 1233, MO0141 Subramaniam, M. 1121, FR0466, MO0202 Suda, N. SU0291 Suda, T. SA0477 Sudhakar, S. MO0063 Sugamori, K. MO0251

Author Index

359

Index

Spagnoli, A. Spangler, L. Spatz, J. Spears, T. Specchia, G. Spector, E. Spector, T. D.

Sugano, M. Sugawara, Y.

SU0335 MO0208, SU0100, SU0211, SU0319 Sugimoto, A. MO0190 Sugimoto, T. 1201, MO0383, SA0183, SA0412, SA0416, SU0256 Sugioka, Y. SU0178 Sugita, S. 1009 Sugitani, M. FR0044, SA0180, SU0473 Suh, K. SA0398 Suh, S. SU0433 Sukhareva, O. SA0006 Sukthankar, S. SA0478 Sukumar, D. MO0396 Sulchek, T. SA0093 Sullivan, K. FR0157, SU0040 Summerford, D. SA0231 Summers, L. SA0119 Sumner, D. FR0210, MO0106, MO0458, MO0462 Sumnik, Z. FR0158 Sumpter, L. SU0393 Sun, B. 1162, MO0192, SA0306 Sun, H. B. 1105, SU0115 Sun, J. FR0206 Sun, L. SU0251 Sun, Q. FR0165, SA0156, SA0165 Sun, X. SU0303 Sundaram, K. FR0164, MO0150, SA0164 Sundstro¨m, J. 1243 Sung, C. SA0302 Suominen, M. I. SA0142, SA0460, SU0324 Sutherland, R. MO0139, SA0136, SU0142 Suto, K. SU0467 Suto, M. SU0467 Sutradhar, S. SU0441 Sutton-Smith, P. SA0314, SA0316 Sutton-Tyrrell, K. SA0364 Sutty, S. MO0054 Suutari, T. SA0460 Suutari, T. Annika SU0324 Suva, L. J. 1181, MO0015, SA0134, SU0146 Suwa, F. SA0099 Suzawa, T. SU0263 Suzuki, A. MO0324, SA0324, SU0119 Suzuki, D. SU0090 Suzuki, H. MO0335, SU0168 Suzuki, K. SU0293 Suzuki, M. SU0237 Suzuki, S. 1149 Suzuki, T. SA0102, SU0237 Svava, R. SA0240 Svedstro¨m, E. SA0421 Svensson, J. MO0215, SU0483 Svircev, J. SA0373, SU0363 Swain, F. MO0015 Swanberg, M. SA0363 Swanson, C. SU0483 Sweetwyne, M. Ts’ana 1218 Swenson, K. SU0153 Swinehart, I. SU0102 Swinkels, L. SU0485, SU0486 360

Syberg, S.

MO0404, MO0457, SA0240, SU0222 Szabo, E. SU0050 Sze Yeo, L. MO0267 Szechinski, J. 1128 Szejnfeld, V. L. MO0004, SA0343 Szewczyk, K. Anita SU0274 Szulc, P. MO0401, SU0403 Szumiloski, J. MO0037, SU0066

T Tørring, O. To¨yra¨s, J. Ty´blova´, M. Taback, S. Tabata, C. Tabatabaei, N. Tachikawa, K. Tada, M. Tada, Y. Taga, R. Taguchi, Y. Tahari, S. Tai, P. Takabatake, K. Takacs, I. Takada, Y. Takagaki, N. Takagi, Y. Takahashi, A. Takahashi, F. Takahashi, M. Takahashi, N. Takahashi, S. Takahata, Y. Takahiro, N. Takaishi, Y. Takaiwa, M. Takakuwa, M. Takami, M. Takano, T. Takano, Y. Takashima, R. Takata, A. Takata, S. Takato, T. Takayama, L. Takayanagi, H. Takeda, E. Takeda, S. Takeda, Y. Takemaru, K. Takemura, A. Takeshita, A. Taketani, Y. Taketsuna, M. Takeuchi, K. Takeuchi, Y. Takeyama, K. Takigawa, M. Takita, M.

1062, FR0446 MO0339 SA0326 FR0030, SA0019 MO0315 SA0021 FR0094, MO0316 SU0178 SA0183 MO0203 SU0305 1183 MO0240 SA0472 MO0180 1161, MO0276, SU0308 SA0442 MO0417, SA0320 SU0284 SA0477 MO0225, SU0085, SU0150, SU0298 MO0105, SA0477 SA0107, SU0086 FR0299 MO0299 MO0249, MO0327 SU0202 SA0431 SU0263, SU0281 SU0287 SA0292 1155 SU0335 MO0225, SU0085 SA0246 MO0363, SU0362 MO0303, SA0232 MO0128, SA0118, SU0177 MO0090, SA0114, SA0477 SU0308 MO0099 SA0099 SU0168 MO0128, SA0118, SU0177 SA0442 1229, SA0143 SA0096, SA0219, SU0168 SA0489 FR0090 FR0147, SA0147 Author Index

Author Index

Teixeira, M. Bianca Cruz Grecco 1072 Teixeira, S. MO0274 Telicka, Z. SA0326 Tell, G. SA0386 Temiyasathit, S. FR0078, SA0078 Tenenhouse, A. 1055 Tenne, M. FR0327 Teramachi, J. 1184, FR0166, SA0155, SU0490 Terek, R. MO0132 Terelius, Y. SU0474 Terreni, V. SA0105 Terrill, N. SA0045 Teruhito, Y. MO0299 Teter, P. SU0374 Teti, A. 1028, 1089, SU0216 Tetradis, S. 1226, FR0253, SU0292 Thabane, L. MO0453, SU0380 Thacher, T. D. MO0019 Thadhani, R. SU0484 Thakker, R. SA0045 Thaler, R. SU0099 Thames, T. MO0381 Thayu, M. FR0029, SA0029 Thekkedam, C. SA0218 Thi, M. M. MO0064 Thiagarajan, G. 1237, SU0114 Thiele, T. 1106 Thies, F. MO0447 Thomas, C. SA0093 Thomas, D. SA0057 Thomas, J. 1240, FR0072 Thomas, M. MO0320 Thomas, S. MO0416, SU0175 Thomas, T. P. MO0189 Thomas, W. SU0252 Thompson, J. 1238 Thompson, L. SA0469, SU0481 Thompson, W. Roy FR0317, SA0317 Thomsen, J. Skovhus MO0080, MO0171, MO0459, SA0298, SU0041 Thorleifsson, G. SA0358, SU0367 Thouverey, C. FR0254, SA0254 Thrailkill, K. M. SU0146 Thudium, C. Schneider SA0298, SU0299 Thuillier, D. SA0216 Thumbigere-Math, V. SU0153 Thurston, A. SA0351 Tian, Q. MO0365 Tickner, J. MO0300, SA0207, SA0297, SU0280 Tien, P. SU0371 Tile, L. SA0420 Tilling, K. 1141 Tilluckdharry, L. SA0387 Timlin, S. SA0421 Ting, H. SU0245 Ting, K. 1117, FR0088, FR0211, SA0104 Tintut, Y. 1226, MO0184, SU0183 Tipps, A. SA0153 Tirosh, A. SU0400 ˚. Tivesten, A SA0010 Tjhia, C. MO0059 361

Index

Takyar, F. Miralireza 1257, SA0230 Talasila, S. FR0009, SA0009 Talavera, J. MO0360 Tam, H. 1169 Tamai, K. 1008 Tamaki, H. SU0069 Tamaki, S. MO0326, SA0329 Tami, A. SA0035 Tamma, R. SU0251 Tamminen, I. S. FR0182, SA0182 Tamulaitiene, M. MO0013, SA0321 Tamura, I. MO0249, SA0238 Tamura, M. SU0247 Tamura, S. SA0016 Tamura, T. SU0281 Tan, M. SA0335 Tanabe, N. MO0304, SA0273 Tanabe, R. MO0190, SA0320 Tanaka, E. 1229, SA0143, SU0283 Tanaka, H. SU0202 Tanaka, I. MO0326, SA0329 Tanaka, K. 1114, MO0322, MO0449, SA0016, SA0442, SU0256, SU0477 Tanaka, S. 1190, MO0128, MO0282, MO0303, MO0322, SA0118, SA0454, SU0297 Tang, A. MO0312 Tang, D. MO0298, SA0075 Tang, J. SU0389 Tang, K. 1017 Tang, N. SA0358 Tang, P. 1233, MO0141 Tang, S. Yue-Cheong 1125, SA0034, SU0116 Tang, T. 1026, 1027, SU0217, SU0464 Tang, W. 1124, FR0177, SA0249 Tanini, A. MO0226, MO0268 Taniuchi, I. MO0087, MO0236 Tanriover, B. 1092, SU0328 Tanzilli, L. MO0337 Tao, J. 1085, MO0246, SU0093 Tarantino, U. MO0051 Tarasuk, V. MO0350 Targownik, L. Ellyn SU0347 Tatakis, D. SU0035 Tau, C. Catalina MO0027 Tavakkol, R. MO0409 Tavakoli, H. SU0231 Tawfeek, H. 1116 Tawfik, O. SA0144 Taxel, P. SU0410 Taylor, A. SU0043 Taylor, A. M. SU0107 Taylor, B. C. SA0355 Taylor, E. MO0164 Taylor, K. 1203 Tchanque-Fossuo, C. N. SU0155 Tchikrizov, V. MO0118 Tebben, P. 1079, MO0019 Tedeschi, L. SU0316 Teglbjærg, C. MO0442 Teichert, A. SA0488 Teitelbaum, S. L FR0299, MO0295, MO0306, SA0279, SA0296, SU0302 Teixeira, G. SA0346

Tjong, W. SU0077 Toben˜a, A. MO0196 Tobias, J. 1032, 1139, 1141, MO0025, MO0160, SA0196, SU0022, SU0158, SU0368 Tobita, K. SA0054 Todaro, M. SA0404 Toguchida, J. SU0187 Tokunaga, K. 1011 Tokuyama, N. 1190 Tolonen, S. SU0020 Tomar, G. MO0265 Tomaschitz, A. SU0346 Tominaga, Y. MO0317 Tominari, T. MO0182, SA0401 Tomlinson, G. SU0452 Tomlinson, R. FR0071, SA0071 Tommasini, S. M. MO0057, SA0076, SU0061 Tomori, K. SU0069 Tomowich, C. SU0405 Tong, J. MO0267 Tong, P. MO0156 Toni, A. SU0084 Tonkin, B. MO0209 Tonna, S. 1257, SA0230 Torgerson, D. 1036 Toribio, R. E. MO0119 Torner, J. MO0046 Toro, E. J. MO0286 Torreggiani, E. SU0246 Torrekens, S. SA0262 Torres, E. MO0131, SU0140 Tosh, D. SU0272 Toshihide, M. MO0299 Tosi, L. L. SA0009 Toth, E. MO0034 Touaitahuata, H. MO0273 Touchberry, C. MO0118 Toussirot, E. MO0181, SU0181 Towheed, T. SU0350 Towler, D. A. 1118, SA0160 Towne, B. 1144, FR0367, MO0195, SA0052, SA0342, SA0379 Townes, T. 1205 Townsley, S. SA0303 Toyama, Y. 1157, SU0279 Tozawa, K. MO0449 Tracy, K. SU0132 Traina, F. SU0084 Trainor, P. SU0005 Tran, A. SU0018 Tran, J. SA0171 Tran, L. MO0285, SU0286 Tran, T. MO0402 Tranquada, C. MO0054 Travers, R. 1083, MO0193 Treece, G. Michael 1127, MO0333 Tremblay, G. B. 1187 Tremoleda, J. 1224 Trimpou, P. MO0357, MO0370 Trinward, A. MO0057, SU0061 Tripathy, D. SA0133 Trivedi, T. MO0138, SU0142 362

Trombone, A. Trompet, S. Trovas, G. P. Troy, K. L. Troy, T. Trubrich, A.

MO0203 1084, SA0358 MO0346 SA0080 MO0148 FR0332, FR0418, MO0397, SA0043, SU0333, SU0418 Trudel, Y. SU0047 Trummer, O. MO0366 Tsang, E. MO0216 Tsilidis, K. 1084 Tsoi, A. SU0207 Tsoukas, G. MO0421 Tsuchie, H. SU0475 Tsuchiya, T. SA0096, SA0219 Tsugawa, N. MO0449 Tsuji, K. 1120, 1197, MO0090 Tsujigiwa, H. SA0472 Tsujimoto, M. SA0417, SU0412 Tsukasaki, M. SU0090 Tsuneki, T. MO0225 Tsuruda, L. 1018 Tsutsumi, S. 1190 Tsygankov, A. SA0305 Tu, C. 1049, 1146, MO0085 Tu, J. 1109 Tu, L. SU0153 Tu, S. SA0151, SA0313 Tu, X. 1050, 1067 Tucci, M. SU0395 Tucker, K. L. MO0352 Tuckermann, J. 1109 Tun, C. MO0063 Tuppurainen, M. MO0375, MO0376 Turan, S. SA0130 Turcotte, R. MO0132 Turner, A. Grant SA0493 Turner, C. MO0196 Turner, R. T. 1004, 1121, SU0204, SU0206 Turteltaub, K. MO0157 Tusquets, I. MO0131, SU0140 Tutton, S. SU0162 Tuukkanen, J. SA0108, SU0257 Tveit, M. FR0020 Tylavsky, F. A. SU0450

U Uchida, K. Uchida, T. Uchiyama, S. Udagawa, N. Udall, W. Uddin, S. M Zia Udesky, J. Ueda, M. Uehata, Y. Ueki, Y. Uemura, Y. Uenaka, K. Uenishi, K. Ueno, D. Uitterlinden, A.

SU0088, SU0467 SU0298 SU0335 MO0105, SA0477 MO0038 MO0075 MO0036, MO0044 SA0099 FR0166, SA0166 FR0190, FR0194 SU0423 SA0417, SU0412 MO0322 SA0463 1142 Author Index

Uitterlinden, A. G. 1084, 1165, FR0367, SA0358, SA0368, SU0198, SU0364, SU0367, SU0372 Uluckan, O. SA0295, SA0303 Ulvskov, P. SA0240 Unni, S. SA0372 Urabe, K. SU0467 Urbanczyk, K. SU0117 Uribe, F. MO0069 Urreizti, R. MO0284 Urushihara, H. SA0442 Ushita, M. 1151 Usmani, S. FR0423 Usui, M. MO0278 Utreja, A. MO0069, MO0123 Utsunomiya, H. SA0096 Uusi-Rasi, K. A. SU0011 Uyama, M. SU0247 Uzbekov, R. SA0402 Uzer, G. MO0065, SA0070

V

Author Index

MO0380, SA0041, SU0057 Van Wijnen, A. J. 1217, FR0312, MO0240, SA0146, SA0224, SA0236, SA0242 Van’t Hof, R. 1082 Vancuntsem, P. SA0022 Vande Woude, G. SA0087 Vandenput, L. SA0196, SA0358, SU0368 Vander Borght, T. MO0420 Vanderoost, J. SU0401 Vanderschueren, D. 1066 Vanegas, D. SA0408 Vanhouten, J. N. 1053, 1153 Vanstaa, T. 1036 Vanstone, C. 1140, MO0340, SU0016 Varela, A. MO0006, MO0017, MO0018, SA0103, SU0047 Varela, E. MO0466 Varga, F. SU0099 Varga, P. SU0035 Varley, I. MO0072 Varshnay, S. MO0174 Vasel, M. MO0234, SA0138 Vashishth, D. 1103, SA0082, SU0059 Vasikaran, S. SU0009 Vasireddy, S. FR0328, SA0328 Vatanparast, H. SU0027 Vattakuzhi, Y. 1159 Vazquez, M. SU0397 Vecchiatini, R. SU0246 Veldkamp, J. SU0313 Veno, P. A. FR0111, SA0111 Verbalis, J. 1169 Verdelis, K. SA0084 Verdoia, C. SU0322 Vergne-Salle, P. SU0329 Vernon-Smith, A. 1084 Vestergaard, P. SA0169, SU0488 Viau, E. 1187 Vicaut, E. SA0403 Vicens-Costa, E. MO0196 Vickers Douglass, K. SU0170 Vico, L. SA0014, SA0077 Victor, D. SA0408 Vidal, C. MO0267, SA0218, SU0208 Vidal, J. FR0066 Vidal, M. 1086 Vieira, A. Espindola MO0203 Vielhauer, G. SA0144 Vietz Andreassen, K. SA0117 Vigna, Y. SU0190 Vignali, E. SA0172 Viguet-Carrin, S. MO0078 Viikari, J. 1084, SA0196, SU0020, SU0368 Vikulina, T. FR0405 Vilardaga, J. SA0114, SA0130, SU0124 Vilayphiou, N. SA0041, SU0057, SU0403 Viljakainen, H. Tuulikki 1180 Viljanen, A. 1216 Villagrana, E. MO0388 Villareal, D. T. 1164 Villiger, P. SU0106 Villinger, F. FR0405 363

Index

Va´zquez, I. SU0420 Va¨a¨na¨nen, K. MO0254 Va¨a¨ra¨niemi, J. SA0460, SU0042, SU0324 Ve´ra, R. SA0451 Vaananen, K. MO0407 Vadakkan, T. MO0108 Vaglio, L. MO0393 Vahula, K. SU0421 Vaillancourt, J. SA0429 Vaillancourt, M. MO0355 Valencia, K. 1232 Valenti, R. SA0394 Valimaki, M. J. SU0451 Valle`s, M. FR0066 Vallarta-Ast, N. FR0330 Vallet-Regı´, M. SU0203 Valta, H. FR0182 Valter, I. SU0421 Valverde-Franco, G. 1150 Van ’t Hof, R. MO0104 Van Den Bergh, J. 1262, SA0337 Van Den Bogert, C. A SA0434 Van Der Deen, M. SA0146 Van Der Horst, M. MO0453 Van Der Meer, R. MO0309 Van Der Meijden, K. SA0495 Van Der Meulen, M. C.H. MO0058, MO0066 Van Der Valk, M. MO0248 Van Duijn, C. 1084, SU0367 Van Dyke, M. MO0313, SU0258 Van Gastel, N. FR0262, SA0262 Van Geel, T. 1262, SA0337 Van Hamburg, J. SA0277 Van Hul, W. SU0144 Van Lenthe, H. MO0391, SU0054, SU0401 Van Lierop, A. 1102, MO0309, SA0393, SU0191 Van Looveren, R. SU0135 Van Meurs, J. BJ SU0198

Van Rietbergen, B.

Viluksela, M. Vincenzini, M. Viollet, B. Virdi, A. S.

SA0108, SU0257 MO0226 1215 FR0210, MO0106, MO0458, MO0462 Virnig, B. FR0355, SA0355 Viswanathan, H. MO0429, SU0439, SU0443, SU0455 Viterbo, G. MO0027 Vittecoq, O. MO0437 Vittinghoff, E. 1063, 1212, SU0008, SU0422 Vlodavsky, I. SU0226 Vogel, P. 1044 Von Au, A. FR0138, SA0138 Von Ingersleben, G. 1128 Vonk, R. MO0468 Vonmaltzahn, R. SU0442 Vora, J. SU0389 Voronov, I. 1016, MO0280 Voss, L. SU0491 Vrang, L. SU0474 Vu Van, T. SU0177 Vu, T. MO0334 Vujevich, K. MO0142 Vunnava, A. FR0405 Vuorikoski, H. SA0142, SU0042 Vyas, K. SU0128 Vynckier, C. MO0420 Vyskocil, V. SU0383

W Wacker, M. Wada, H. Wada, T. Wada, Y. Wade, S. Wade-Gueye, N. Wadeer, S. Wadhwa, S. Waern, E. Wagman, R. Wagner, D. Wagner, J. Wagoner, W. Wahl, E. Wakabayashi, M. Wakitani, S. Wald, M. Jeffrey Waldstein, S. Walker, E. Walker, M. D. Walkley, C. Wallace, R. Walrand, S. Walsh, B. Walsh, D. Walsh, J. Walsh, J. Bernard Walsh, J. S. Walsh, N. 364

MO0118 FR0475, MO0371 MO0427 FR0285 SU0443 SA0348 FR0059 MO0069, MO0123 SU0125 1061, FR0446 MO0428, SA0424, SU0055 MO0142 SU0192 SU0146 1155 SA0098 MO0183 MO0374 1048 1099, MO0036, MO0044, SA0048, SA0168, SU0166 SU0148 SU0422 SA0014, SA0077 SU0331 SU0045 SA0336, SU0415 MO0323, SU0331 SU0058 MO0465

Walsh, N. C.

MO0154, MO0209, SA0201, SU0234 Walsh, P. SA0362 Walter, D. MO0366 Wan, M. 1006, 1193, MO0127 Wan, X. 1055, 1203, 1204, FR0414, MO0330 Waneck, R. FR0332, FR0418 Wang, A. 1062, FR0446, MO0285, SU0455 Wang, B. 1223 Wang, C. MO0238 Wang, E. MO0281 Wang, F. FR0163, FR0165, SA0163 Wang, H. SA0017, SA0113, SU0161, SU0174 Wang, J. 1107, FR0215, MO0220, SU0161, SU0414, SU0482 Wang, L. 1005, 1085, FR0089, FR0115, FR0391, MO0256, SA0089, SA0258, SA0391, SU0089, SU0199, SU0269 Wang, M. 1223 Wang, N. MO0404 Wang, P. SA0173, SU0167 Wang, Q. MO0334, SU0122, SU0411 Wang, W. MO0089 Wang, X. MO0059, MO0308 Wang, Y. FR0214, MO0085, MO0145, MO0211, MO0298, SA0214, SA0304, SA0399, SA0427, SU0071, SU0094, SU0399 Wang, Z. FR0215, SA0294, SU0072 Wani, M. R. MO0265 Ward, L. FR0030, SA0019 Ward, M. MO0429 Ward, W. E. SA0469, SU0481 Warden, S. J. 1104, MO0023, MO0482, SU0025, SU0402 Wareham, N. 1084 Warensjo¨-Lemming, E. SU0354 Waring, A. MO0384 Wark, J. D. SA0404 Warmington, K. 1208 Warraich, S. SU0184 Warren, A. 1110, 1168, 1189, FR0002, MO0476, SU0470 Warren, C. Robert SU0138 Warren, G. SU0024 Warren, J. T. FR0279, SA0279 Warriner, A. FR0325, MO0452, SA0325 Washington, T. MO0388 Wastney, M. E. SA0175 Watahiki, J. SU0263 Watanabe, C. MO0237 Watanabe, H. SA0107, SU0086 Watanabe, K. 1229, MO0097, SA0068, SA0143, SA0266, SU0309 Watanabe, T. MO0266, SA0320, SU0471 Watari, E. SU0177 Watkins, M. P. 1115, 1235, FR0259, MO0003, SA0259 Watson, M. MO0156, MO0211 Watson, R. MO0314, SA0103 Wattanachanya, L. FR0391, MO0241 Watts, H. 1122 Watts, N. B. 1024, 1080, MO0369, MO0377, SA0377 Author Index

Author Index

Whyte, M. P. Wiberg, A. Widmer, J. Wieffer, H. Wiersma, J. Wiggs, M. Wijenayaka, A. Wikstrom, K. Wild, J. Wilhelmsen, L. Willems, P. Willett, T. Willett, T. L. Williams, A. Williams, B. O. Williams, C. Williams, D. Williams, G. Williams, J. Williams, P. Williams, R. Williams, T. Williamson, E. Williamson, G. Willie, B. M. Wilson, A. Wilson, S. G. Wilt Peters, K. Windahl, S. H. Windebank, A. Windle, J. Windle, J. J. Windolf, M. Winemaker, M. Winer, K. K. Winkelmann, C. Winterhalder, L. Wintgens, K. Winzer, M. Wirth, A. Wischer, T. Wise, J. Wissgott, C. Witt-Enderby, P. Wittrant, Y. Wixted, J. Wluka, A. Wohl, G. Wojda, S. Wolf, J. Wollberg, V. Wolos, J. Woloszczuk, W. Womack, C. R. Wong, A. Wong, C. Wong, J. Wong, Q. Woo, J. Woo, K. Wood, A.

MO0193 SU0214 SU0106 SU0442 MO0477 MO0149 1042 SU0474 MO0397 MO0357, MO0370 SA0337 SU0147 MO0054 1208, MO0104, MO0281, SA0152, SU0105 1220, SA0097, SA0145 1077 MO0037, MO0269, SU0066 MO0211, SA0045 MO0482, SU0079 MO0471, MO0489 1159 MO0015 SU0492 SA0450 1106 1191 1084 1241 FR0482, MO0215, MO0479, SU0483 SA0017 FR0165 1184, FR0166, SU0490 SA0035 SU0405 1143 SU0066 SU0106 MO0009 FR0255 MO0391 SA0425 FR0210, SA0210 SU0454 Ann SA0220 MO0002, SA0458, SU0294 FR0312 SA0481, SU0341 SU0044 MO0460 SU0288 SU0193 MO0147, SU0461 MO0397 SU0008 FR0357, MO0011, SA0357 1004 SA0314, SA0316 SU0338 SU0205 FR0187, SU0201 SA0457 365

Index

Wauquier, F. MO0002, SU0294 Weaver, C. M. MO0023, MO0321, MO0467, MO0477, MO0482, SA0175, SU0025, SU0469 Weaver, F. SA0373, SU0363 Webber, C. E. MO0011, SA0333, SA0357 Weber, J. SU0212 Weedon, H. MO0283 Weh, M. SU0040 Wehbi, V. SU0124 Wehbi, V. L. SA0130 Wehr, E. MO0366 Wehrli, F. MO0183 Wei, J. MO0252 Wei, S. FR0290, MO0293 Weigt, C. FR0069 Weilbaecher, K. N. 1086, SA0295, SA0303 Weiler, H. A. 1140, MO0110, MO0340, SA0021, SA0344, SU0016 Weinstein, L. S. 1037 Weinstein, R. 1039, 1110, 1168, 1209, MO0476, SU0470 Weinstein, R. L. 1061 Weis, M. MO0107 Weiss, A. FR0284 Weitzmann, M. 1116, FR0405, SA0128, SA0212 Welbel, R. SA0338 Wellik, D. M. SU0102 Wells, D. MO0173 Wenderoth, D. H. SU0421 Wendling, D. MO0181, SU0181 Wenger, J. SU0484 Wenger, K. 1177 Wenkert, D. 1080, SA0024, SU0032, SU0193 Wentzell-Larsen, T. 1261 Wergedal, J. E. 1122, 1172, SA0015, SU0221 Wermers, R. A. MO0405, SU0170 Werner, S. SU0310 Wesolowski, G. MO0469 Wesseling, K. SU0318 West, D. FR0423 West, J. SA0225, SU0040 West, S. L. MO0177, SU0175 Westendorf, J. J. 1045, 1152, FR0086, MO0277, SA0228 Westphal, T. MO0130 Whalen, J. MO0148, SA0150 Wheal, B. MO0304, SA0273 Wheeler, L. M. SA0028 Wheeler, V. SA0364 White, J. SU0443 White, K. MO0154 White, K. E. SA0119 White, L. 1083, 1185 Whitfield, T. MO0240 Whitley, A. MO0196 Whitmarsh, T. MO0056 Whitmore, K. SA0076 Whitson, R. 1155 Whittaker, J. SA0028 Whyte, L. SA0300 Whyte, M. 1080, SA0024, SU0032, SU0185, SU0193

Woodruff, K. Woodson, Iii, G. Worton, L. E. Wren, T. A.L. Wright, L. E. Wright, N. C.

MO0308, SA0408 1203 SU0070, SU0228 1143 MO0133, SU0390 1246, MO0419, MO0452, SU0326, SU0387, SU0427 Wronski, T. J. 1044, 1075, 1208, SA0109, SA0152, SA0260, SU0105, SU0267, SU0320 Wu, B. FR0088, MO0216 Wu, C. 1128, SA0229 Wu, E. SU0139 Wu, G. 1030 Wu, H. 1026, 1027, MO0240, SA0242, SU0217 Wu, J. Y. FR0267 Wu, K. SA0303 Wu, M. SA0304 Wu, Q. FR0215 Wu, X. 1013, 1186, 1193, FR0466, SA0222 Wu, Y. SU0271 Wuerfel, C. MO0234 Wurzbacher, K. SA0342, SA0379 Wuttke, W. SU0004 Wylie, C. SA0091 Wyman, A. 1024, FR0439 Wynne, R. MO0262 Wysocki, N. M. SA0338 Wysolmerski, J. J. 1053, SA0126, SU0126

X Xia, X. Xian, L. Xiao, A. Xiao, G. Xiao, L. Xiao, S. Xiao, Y. Xie, C. Xie, H. Xie, R. Xie, X. Xie, Y. Xie, Z. Xin, X. Xing, L.

1208, FR0073, SA0152, SU0105 1006, 1193 MO0101 1046, MO0239 1029, SA0204, SA0463, SU0238 1084 1052 SA0129, SA0476 1154 SA0236 SA0155 SA0111 1240, FR0072, SU0074 MO0159, SA0258, SU0269 1233, 1254, MO0141, MO0146, SU0306 Xing, S. FR0252 Xing, W. 1172, 1178 Xiong, J. 1039, 1041, 1110, FR0409 Xiong, W. SU0096 Xiu, Y. SU0306 Xu, F. SU0262 Xu, G. 1090 Xu, H. MO0148, MO0239 Xu, J. MO0296, MO0300, MO0301, SA0207, SA0297, SA0302, SU0280 Xu, L. MO0254, SU0411 Xu, M. MO0069, MO0123 Xu, Q. 1169 Xu, X. FR0492, SA0492 Xu, Y. MO0096, MO0290, MO0429 366

Xuan, S. Xue, M. Xue, Y.

1193 1147, 1219, SU0232 1052

Y Yabushita, N. Yaccoby, S. Yadav, M. Yadav, M. C. Yadav, S. Yadav, V. K. Yajima, A. Yam, L. Yamachika, E. Yamada, A.

SA0016 MO0145 SA0186 FR0193, MO0109, SA0125 MO0086 SU0460 MO0317 SU0271 SA0472 MO0208, SU0090, SU0100, SU0211, SU0263, SU0281 Yamada, H. FR0044, SA0180, SU0473 Yamada, M. MO0050, SA0065 Yamada, S. MO0114, SA0116, SU0293 Yamada, Y. SA0127 Yamaguchi, A. MO0266, SA0320, SU0090, SU0205 Yamaguchi, D. T FR0205 Yamaguchi, M. FR0405, SA0212 Yamaguchi, T. MO0383, SA0183 Yamamoto, G. SU0090 Yamamoto, H. MO0128, SA0118, SU0177 Yamamoto, M. MO0278, MO0383, SU0090, SU0293 Yamamoto, N. SA0349, SU0456 Yamamoto, T. MO0237, MO0315, SA0442 Yamana, K. 1145 Yamanaka, S. 1183 Yamashiro, T. FR0090, MO0067, SU0265, SU0319 Yamashita, T. SU0407 Yamauchi, M. MO0383 Yamaza, T. SU0287 Yamazaki, R. SU0407 Yan, Y. SA0202, 1126 Yanagi, H. SA0016 Yanaka, K. MO0389 Yang, C. FR0148, MO0127, MO0151, SA0148 Yang, D. FR0131, MO0229 Yang, E. SU0295 Yang, F. 1013, 1186, SA0222 Yang, H. MO0096 Yang, J. FR0392, MO0083, SA0269, SA0288 Yang, K. 1138 Yang, L. MO0038, MO0096 Yang, N. SA0213, SU0266 Yang, P. MO0450 Yang, Q. MO0244, SU0391 Yang, R. MO0235, SA0468 Yang, S. FR0268, FR0375, MO0238, MO0239, MO0240, SA0268, SA0375, SU0386 Yang, T. MO0107, MO0365 Yang, W. 1073, FR0215 Yang, X. 1186, FR0059, MO0066, MO0089, SA0132, SA0222, SU0064, SU0236 Yang, Y. FR0095, MO0442, SU0455 Author Index

Yang, Z. Yano, A. Yano, F. Yano, S. Yano, T. Yao, G. Yao, J. Yao, W.

Author Index

Yoon, S. Yoon, W. Yoshikawa, H.

SU0406 SU0201 1156, 1201, SA0178, SA0412, SU0407 Yoshikawa, N. SA0099 Yoshikawa, Y. MO0249, SA0238 Yoshiko, Y. SA0121 Yoshimura, A. SU0279 Yoshimura, N. 1011, 1036, MO0385, SU0378 Yoshino, Y. MO0324, SA0324, SU0119 Yoshioka, H. SA0121 Yoshitaka, T. FR0190, FR0194, SA0190 Yoshizawa, T. FR0003 Yoskovitz, G. MO0284 Yotani, k. SU0069 You, L. MO0311, SA0281 You, M. 1049, 1146, MO0085 Youn, M. FR0287, SA0287, SA0483 Young, A. SU0121 Young, D. SA0146 Young, K. SU0453 Young, M. F. SU0110 Yu, A. SU0139 Yu, B. 1006, MO0127, SA0390 Yu, E. W. 1101, MO0120, SU0043 Yu, H. 1122, MO0244 Yu, L. MO0248 Yu, O. SA0352 Yu, S. 1046, MO0239, SU0197, SU0241 Yu, Y. FR0215, MO0223, SA0215, SA0279 Yu, Z. MO0345 Yuan, B. FR0032, MO0112, MO0319, SA0032 Yuan, J. 1186 Yuan, Q. 1054 Yuan, W. FR0211 Yue, L. SU0275 Yuen, E. MO0149, MO0227, SA0226 Yukata, K. SA0476 Yuki, A. SU0069 Yun, C. SA0288, SU0209 Yun, H. 1246, 1247, FR0433, MO0419, MO0430, SU0326, SU0427 Yun, J. SU0366 Yurgin, N. MO0441, SA0445, SU0442

Z Zach, P. Zah, A. Zaidi, M. Zallone, A. M. Zambonin, C. Zanchetta, J. Zanchetta, M. Zandueta, C. Zannettino, A. Zanotti, S. Zaolino, C. Zaouter, C. Zapletalova, J. Zappitelli, T.

SA0346 SA0243 SU0251 SA0149, SU0251, SU0392 SU0251 1064, MO0061, SA0047, SA0396, SU0421 FR0396, SA0047, SA0396 1232 MO0283 1010, 1033, 1253, SU0225 SU0447 SA0247 FR0158 1182 367

Index

MO0298, SU0217 MO0278, SU0293 1011, SA0246 MO0383, SA0183 MO0050, SA0065 MO0288 SA0031 1025, SA0064, SA0467, SA0479, SU0002, SU0045, SU0317 Yao, Y. SA0372 Yao, Z. 1046, 1254, SU0230, SU0306 Yap, P. FR0061, SA0049 Yashiro, W. 1161 Yasuda, H. 1190, MO0221, SA0477, SU0088, SU0297 Yasuhiro, K. MO0299 Yasui, N. MO0225, SU0085, SU0150 Yasui, T. 1190, MO0282 Yaszemski, M. J. MO0103, MO0151, MO0405, SA0017 Yates, M. SU0426 Yavropoulou, M. MO0353 Yavropoulou, M. P. 1102 Yawn, B. MO0019 Yazawa, H. SU0471 Yazawa, K. MO0473 Ye, A. FR0492 Ye, H. SU0161 Ye, L. MO0290 Ye, S. 1014, 1192, MO0296 Yeap, Y. SA0314, SA0316 Yee, C. FR0208 Yeh, J. SA0470 Yeh, R. SU0067 Yerges-Armstrong, L. M. 1096, FR0197, FR0199, FR0367, SA0197, SA0358, SU0241, SU0367 Yi, D. SU0141 Yihua, Y. SA0240 Yim, H. SU0375 Yim, M. SU0281 Yin, J. Ivy SU0132 Yin, M. 1003 Yin, M. T. SA0048, SU0371 Yirmiya, R. SU0392 Yogendran, M. SA0438 Yoh, K. SA0442 Yokota, H. 1013, MO0217, SU0115 Yokouchi, M. MO0091, SU0244 Yokoyama, M. SU0202 Yokoyama, S. FR0147 Yoneda, T. 1155 Yoneyama, K. 1149, MO0199, SA0244 Yonezawa, T. SU0205 Yonezu, H. SU0449 Yong, W. MO0083, SU0230 Yoo, H. SU0366 Yoo, J. SA0012, SA0398 Yoo, M. SA0398 Yoon, B. SU0424 Yoon, H. 1138, MO0356, SU0361, SU0424, SU0434 Yoon, K. MO0201

Zara, J. 1117, FR0088, FR0211, SA0104 Zarei, A. SU0180 Zarka, J. MO0060 Zarkadis, N. 1222 Zavratnik, A. MO0438 Zayzafoon, M. 1230, FR0311, FR0405, MO0155 Zcharia, E. SU0226 Zebaze, R. 1064, 1129, MO0014, MO0334, SU0334 Zeiss, D. SU0031 Zeitz, U. SA0120 Zelenchuk, L. SU0120 Zelenika, D. SA0198 Zeller, A. MO0362 Zemel, B. 1143, SA0029 Zemkova, D. FR0158 Zeng, H. MO0246 Zeng, Q. FR0414, SU0130 Zeni, S. SU0398 Zhan, S. SU0269 Zhang, B. 1026, 1027, SA0471, SU0217 Zhang, C. 1092, 1099, 1231, MO0172, MO0176, SA0047, SA0168, SA0249, SA0415, SU0328, SU0371, SU0414, SU0430 Zhang, D. SU0095 Zhang, F. 1219 Zhang, G. 1026, 1027, FR0079, SA0471, SU0217, SU0464 Zhang, H. MO0096 Zhang, J. 1246, MO0262, MO0463, SA0023, SA0441, SU0326 Zhang, L. 1026, 1027, 1174, FR0079, MO0290, SU0217 Zhang, M. MO0115, SU0199 Zhang, N. MO0148, SA0150 Zhang, P. 1013, 1186, FR0290 Zhang, Q. MO0112 Zhang, R. MO0319, SA0289 Zhang, W. FR0115, MO0218, SA0067, SA0115 Zhang, X. 1046, 1078, 1080, 1117, 1147, 1219, FR0088, FR0211, MO0092, MO0470, SA0104, SA0476 Zhang, Y. 1109, 1174, 1174, 1239, FR0291, MO0096, SA0087, SA0229, SA0236, SA0380, SU0039, SU0197, SU0241 Zhang, Z. SU0227 Zhao, B. 1158 Zhao, G. MO0244, SA0085 Zhao, H. 1014, 1039, 1068, 1189, 1192, MO0083, MO0296, SA0272, SU0326 Zhao, J. MO0010, MO0194 Zhao, K. FR0215 Zhao, L. FR0492, MO0217 Zhao, M. SA0289 Zhao, W. MO0191 Zhao, X. 1006, MO0096, MO0127, MO0231 Zhao, Y. 1122, SA0356 Zheng, D. SU0157 Zheng, H. 1084, FR0199, FR0367, SA0199

368

Zheng, L. SU0464 Zheng, M. 1192, MO0296, MO0300, MO0301, SA0207, SA0297, SA0302, SU0280 Zheng, Q. SU0321 Zheng, Y. 1174, FR0136, MO0138, MO0139, SA0136, SU0142 Zhong, Q. MO0258, SA0286 Zhong, W. FR0115 Zhong, Z. 1220 Zhou, B. 1107, FR0492, MO0044, SA0048, SU0414, SU0460 Zhou, D. 1109, MO0138, MO0139, SA0136, SU0142 Zhou, G. 1008, MO0255 Zhou, H. 1200, 1202, 1203, MO0061, MO0391, SA0415, SU0123, SU0376, SU0414 Zhou, R. MO0083 Zhou, S. MO0206, MO0342, SU0268, SU0282 Zhou, W. MO0083, SU0350, SU0370 Zhou, X. 1038, 1071, FR0319, SA0319, SU0393 Zhou, Y. 1165, FR0492, SA0365, SU0367 Zhou, Z. SU0096 Zhu, C. SU0301 Zhu, D. MO0185, SA0186 Zhu, E. 1112 Zhu, F. MO0194 Zhu, J. MO0092, MO0129 Zhu, K. 1163, MO0345 Zhu, M. 1162, FR0306, SA0306 Zhu, T. SA0296, SU0302 Zhu, Y. SA0380 Zhuo, Y. MO0472 Zio´łkowska, H. MO0178 Zikan, V. SA0326 Ziller, V. SA0437 Zillikens, C. 1165, SU0364 Zillikens, M. 1036, 1084, SA0358, SA0368, SU0367, SU0372 Zimmermann, E. 1108, SA0034, SU0049 Zion, M. MO0413 Zirngibl, R. A. 1182, SA0484 Zitsman, J. SA0018 Zmuda, J. SU0241 Zmuda, J. M. MO0343, MO0347, MO0384, SA0012, SA0364, SA0388, SU0197 Zoehrer, R. SU0035 Zonefrati, R. MO0226, MO0268 Zou, W. FR0299, MO0295, MO0306, SA0296, SU0302 Zoubos, A. SA0452 Zreiqat, H. SU0232 Zuk, P. MO0204, MO0216 Zukowski, K. SU0007, SU0382 Zurfluh, R. MO0396 Zutter, M. SA0294 Zwahlen, A. 1202 Zysset, P. FR0413 Zysset, P. K. SU0035, SU0056, SU0333

Author Index

This index lists all Symposia, State-of-the-Art Lecture, Clinical Roundtable, Meet-the-Professor and Committee-Sponsored Session presenters. For all abstract presenters, please refer to the Abstract Author Index beginning on page 313.

A Andersen, T. Levin

J pg. 206

B Bachrach, L. K. Baldock, P. A. Baron, R. Bauer, D. C. Bhasin, S. Bianco, P. Bilezikian, J. Bindels, R. Bonewald, L. F. Bouxsein, M. L.

pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206, 206, 206 pg. 206 pg. 206, 206 pg. 206

C Cao, X. Carmeliet, G. J.V. Clemens, T. L. Cosman, F.

pg. 206 pg. 206 pg. 206 pg. 206

Dawson-hughes, B. Dell, R. Demay, M. Demer, L. L. Dempster, D. W. Divieti Pajevic, P. Duncan, R. L.

pg. 206 pg. 206 pg. 206 pg. 206, 206 pg. 206 pg. 206 pg. 206

E Eastell, R. Economides, A. N. Econs, M. J. Einhorn, T. A.

pg. 206, 206 pg. 206 pg. 206 pg. 206

F Farber, C. R. Favus, M. J. Francis, R. Michael Frenette, P. S.

Gaddy, D. Glorieux, F. H. Gordon, C. M.

Presenter Index

Katz, S. Kaufman, K. R. Kehoe, T. E. Klibanski, A. Kohrt, W. M. Krakow, D.

Laschever, S. Lau, E. Leboff, M. S. Lee, B. Leonard, M. B. Lian, J. B. Lichtler, A. Lloyd, K. C.

pg. 206 pg. 206 pg. 206, 206 pg. 206, 206 pg. 206 pg. 206 pg. 206 pg. 206

M Maes, C. Magaziner, J. Majumdar, S. Marcus, R. Matsuo, K. Mccauley, L. K. Mccloskey, E. V. Mcclung, M. R. Mcgowan, J. A. Mclellan, A. R. Millan, J. Miller, P. D. Mitchell, P. James

pg. 206 pg. 206 pg. 206

P

pg. 206 pg. 206 pg. 206

pg. 206 pg. 206 pg. 206 pg. 206, 206 pg. 206 pg. 206

L

O

H Hamrick, M. W. Helfrich, M. H. Herman, J.

K

pg. 206 pg. 206 pg. 206 pg. 206

G

pg. 206 pg. 206 pg. 206

Olson, E. N. Ominsky, M. S. Orwoll, E. S. Oursler, M.

Pettit, A. R. Prince, R. L.

pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206

pg. 206 pg. 206 pg. 206, 206, 206 pg. 206

pg. 206 pg. 206

R Rajamannan, N. M. Recker, R. R. Roodman, G.

pg. 206 pg. 206, 206 pg. 206, 206

369

Index

D

Jacobs, C. R. Jilka, R. L. Johnson, M. L.

Rosen, C. J. Rosen, V.

pg. 206, 206 pg. 206

S Saag, K. G. San Martin, J. A. Shane, E. Shaughnessy, J. Shore, E. M. Shulman, G. Silva, M. Silverberg, S. J.

370

Stern, P. H. Studenski, S.

pg. 206 pg. 206

W pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206

Watts, N. B. Weaver, C. M. Weihl, C. Westendorf, J. J. Whitehouse, C. Alicia Whyte, M. P. Wu, J. Y.

pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206 pg. 206

Presenter Index