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176 (1) J Immunol 2006; 176:1-677; ; http://www.jimmunol.org/content/176/1 This information is current as of October 16, 2017.

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606.

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VOL. 176

ⱍ NO. 1 ⱍ January 1, 2006 ⱍ Pages 1– 698

THE

TABLE OF CONTENTS

1

In This Issue Pillars of Immunology

3

Shaping the T Cell Repertoire Harald von Boehmer

5

Pillars Article: In a Radiation Chimaera, Host H-2 Antigens Determine Immune Responsiveness of Donor Cytotoxic Cells. Nature, 1977. 269: 417– 418. Michael J. Bevan

Cutting Edge 7

Cutting Edge: The AP-1 Subunit JunB Determines NK Cell-Mediated Target Cell Killing by Regulation of the NKG2D-Ligand RAE-1⑀ Norman Nausch, Lore Florin, Bettina Hartenstein, Peter Angel, Marina Schorpp-Kistner, and Adelheid Cerwenka

12

Cutting Edge: Extracellular High Mobility Group Box-1 Protein Is a Proangiogenic Cytokine Stefania Mitola, Mirella Belleri, Chiara Urbinati, Daniela Coltrini, Bianca Sparatore, Marco Pedrazzi, Edon Melloni, and Marco Presta

Cellular Immunology and Immune Regulation 17

A Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice Silvia Musio, Barbara Gallo, Stefano Scabeni, Marilena Lapilla, Pietro L. Poliani, Giuseppe Matarese, Hiroshi Ohtsu, Stephen J. Galli, Renato Mantegazza, Lawrence Steinman, and Rosetta Pedotti

27

Hydrolytic and Nonenzymatic Functions of Acetylcholinesterase Comodulate Hemopoietic Stress Responses Dan Grisaru, Marjorie Pick, Chava Perry, Ella H. Sklan, Ronit Almog, Ilan Goldberg, Elizabeth Naparstek, Joseph B. Lessing, Hermona Soreq, and Varda Deutsch

36

Novel Insights into the Mechanism of Action of FTY720 in a Transgenic Model of Allograft Rejection: Implications for Therapy of Chronic Rejection Antje Habicht, Michael R. Clarkson, Jun Yang, Joel Henderson, Volker Brinkmann, Stacey Fernandes, Mollie Jurewicz, Xueli Yuan, and Mohamed H. Sayegh

On the cover: Photomicrograph of epifluorescence microscope analyses of expression of TGF␤2 and TGF␤ RI by T cells cocultured with iris pigment epithelium (IPE). T cells exposed to IPE and anti-CD3 express TGF␤ RI (green) diffusely on the cell surface; IPE express TFG␤ RI on the nuclear membrane; T cells expressing both TGF␤2 (red) and RI (green) appear yellow in the photomicrograph. Sugita, S., T. F. Ng, P. J. Lucas, R. E. Gress, and J. W. Streilein. 2006. B7⫹ iris pigment epithelium induce CD8⫹ T cells regulatory; both suppress CTLA-4⫹ T cells. J. Immunol. 176: 118 –127. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3998. Subscription term: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). Periodicals postage paid at Bethesda, MD 20814-3998, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes to The Journal of Immunology, Subscription Department, Room L-2407A, 9650 Rockville Pike, Bethesda, MD 20814-3998. Copyright © 2005 by The American Association of Immunologists, Inc.

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JOURNAL

IMMUNOLOGY OF

43

The Membrane-Bound Chemokine CXCL16 Expressed on Follicle-Associated Epithelium and M Cells Mediates Lympho-Epithelial Interaction in GALT Koji Hase, Takaya Murakami, Hiroyuki Takatsu, Takeshi Shimaoka, Mitsutoshi Iimura, Kimiyo Hamura, Kazuya Kawano, Sayaka Ohshima, Risa Chihara, Kikuji Itoh, Shin Yonehara, and Hiroshi Ohno

52

Integrin ␣IIb␤3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen Toshihiko Oki, Jiro Kitaura, Koji Eto, Yang Lu, Mari Maeda-Yamamoto, Naoki Inagaki, Hiroichi Nagai, Yoshinori Yamanishi, Hideaki Nakajina, Hidetoshi Kumagai, and Toshio Kitamura

61

Tumor-Infiltrating Dendritic Cells Are Potent Antigen-Presenting Cells Able to Activate T Cells and Mediate Tumor Rejection Olivier Preynat-Seauve, Prisca Schuler, Emmanuel Contassot, Friedrich Beermann, Bertrand Huard, and Lars E. French

68

Heterogeneous Nuclear Ribonucleoprotein P2 Is an Autoantibody Target in Mice Deficient for Mer, Axl, and Tyro3 Receptor Tyrosine Kinases Marko Z. Radic, Kinjal Shah, Wenguang Zhang, Qingxian Lu, Greg Lemke, and George M. Hilliard

75

Premature Expression of Chemokine Receptor CCR9 Impairs T Cell Development Shoji Uehara, Sandra M. Hayes, LiQi Li, Dalal El-Khoury, Matilde Canelles, B. J. Fowlkes, and Paul E. Love

Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes Zdeneˇk Hel, Wen-Po Tsai, Elzbieta Tryniszewska, Janos Nacsa, Phillip D. Markham, Mark G. Lewis, George N. Pavlakis, Barbara K. Felber, Jim Tartaglia, and Genoveffa Franchini

97

Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors Vikas Sharma, Mario Delgado, and Doina Ganea

111

␣-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis Hyunil Ha, Jong-Ho Lee, Ha-Neui Kim, Hyun-Man Kim, Han Bok Kwak, Seungbok Lee, Hong-Hee Kim, and Zang Hee Lee

118

B7⫹ Iris Pigment Epithelium Induce CD8⫹ T Regulatory Cells; Both Suppress CTLA-4⫹ T Cells Sunao Sugita, Tat Fong Ng, Philip J. Lucas, Ronald E. Gress, and J. Wayne Streilein

128

Allograft Rejection Requires STAT5a/b-Regulated Antiapoptotic Activity in T Cells but Not B Cells Ye Zhang, Robert A. Kirken, Lucrezia Furian, Slawa Janczewska, Xiumei Qu, Wayne W. Hancock, Mouer Wang, Neelam Tejpal, Ronald Kerman, Barry D. Kahan, and Stanislaw M. Stepkowski

138

Helminth-Modified Pulmonary Immune Response Protects Mice from Allergen-Induced Airway Hyperresponsiveness Niamh E. Mangan, Nico van Rooijen, Andrew N. J. McKenzie, and Padraic G. Fallon

148

Differential Gene Expression in Endometrium, Endometrial Lymphocytes, and Trophoblasts During Successful and Abortive Embryo Implantation Chandrakant Tayade, Gordon P. Black, Yuan Fang, and B. Anne Croy

157

The TLR-7 Agonist, Imiquimod, Enhances Dendritic Cell Survival and Promotes Tumor AntigenSpecific T Cell Priming: Relation to Central Nervous System Antitumor Immunity Robert M. Prins, Noah Craft, Kevin W. Bruhn, Haumith Khan-Farooqi, Richard C. Koya, Renata Stripecke, Jeff F. Miller, and Linda M. Liau

165

Reduced Ability of Neonatal and Early-Life Bone Marrow Stromal Cells to Support Plasmablast Survival Maria Pihlgren, Mathieu Friedli, Chantal Tougne, Anne-Franc¸oise Rochat, Paul-Henri Lambert, and Claire-Anne Siegrist

173

The Glycosaminoglycan-Binding Domain of Decoy Receptor 3 Is Essential for Induction of Monocyte Adhesion Yung-Chi Chang, Yueh-Hsuan Chan, David G. Jackson, and Shie-Liang Hsieh

181

Gap Junction-Mediated Intercellular Communication between Dendritic Cells (DCs) Is Required for Effective Activation of DCs Hiroyuki Matsue, Jian Yao, Keiko Matsue, Akiko Nagasaka, Hideaki Sugiyama, Rui Aoki, Masanori Kitamura, and Shinji Shimada

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85

191

Regulation of Myeloid Cell Function through the CD200 Receptor Maria C. Jenmalm, Holly Cherwinski, Edward P. Bowman, Joseph H. Phillips, and Jonathon D. Sedgwick

200

The CD8⫹ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-Term Immunity Teng-Chih Yang, James Millar, Timothy Groves, Natalie Grinshtein, Robin Parsons, Shunsuke Takenaka, Yonghong Wan, and Jonathan L. Bramson

211

Expression of CD161 (NKR-P1A) Defines Subsets of Human CD4 and CD8 T Cells with Different Functional Activities Tsuyoshi Takahashi, Sussan Dejbakhsh-Jones, and Samuel Strober

217

Induction of Antitumor Immunity by CTL Epitopes Genetically Linked to Membrane-Anchored ␤2-Microglobulin Alon Margalit, Helena M. Sheikhet, Yaron Carmi, Dikla Berko, Esther Tzehoval, Lea Eisenbach, and Gideon Gross

225

Enhanced Regulatory T Cell Activity Is an Element of the Host Response to Injury Niamh Ni Choileain, Malcolm MacConmara, Yan Zang, Thomas J. Murphy, John A. Mannick, and James A. Lederer

IL-27 Limits IL-2 Production during Th1 Differentiation Alejandro V. Villarino, Jason S. Stumhofer, Christiaan J. M. Saris, Robert A. Kastelein, Frederic J. de Sauvage, and Christopher A. Hunter

248

Virus or TLR Agonists Induce TRAIL-Mediated Cytotoxic Activity of Plasmacytoid Dendritic Cells Laurence Chaperot, Ariane Blum, Olivier Manches, Gabrielle Lui, Juliette Angel, Jean-Paul Molens, and Joe¨l Plumas

256

The Novel Cytokine p43 Induces IL-12 Production in Macrophages via NF-␬B Activation, Leading to Enhanced IFN-␥ Production in CD4⫹ T Cells Eugene Kim, Seung Hyun Kim, Sunghoon Kim, and Tae Sung Kim

265

Cellular and Molecular Mechanisms of the Selective Regulation of IL-12 Production by 12/15-Lipoxygenase Melissa K. Middleton, Tanya Rubinstein, and Ellen Pure´

275

PU.1 Regulates Cathepsin S Expression in Professional APCs Ying Wang, Rebecca M. Baron, Guangli Zhu, Myungsoo Joo, John W. Christman, Eric S. Silverman, Mark A. Perrella, Richard J. Riese, and Manuela Cernadas

284

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression Stephanie K. Bunt, Pratima Sinha, Virginia K. Clements, Jeff Leips, and Suzanne Ostrand-Rosenberg

291

Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient Mice Daniel B. Graham, Michael P. Bell, Megan M. McCausland, Catherine J. Huntoon, Jan van Deursen, William A. Faubion, Shane Crotty, and David J. McKean

301

Molecular, Cellular, and Antigen Requirements for Development of Age-Associated T Cell Clonal Expansions In Vivo Ilhem Messaoudi, Jessica Warner, Dragana Nikolich-Zˇugich, Miranda Fischer, and Janko Nikolich-Zˇugich

309

Synergistic Activation of Macrophages via CD40 and TLR9 Results in T Cell Independent Antitumor Effects Ilia N. Buhtoiarov, Hillary D. Lum, Gideon Berke, Paul M. Sondel, and Alexander L. Rakhmilevich

319

Immunodomination in the Evolution of Dominant Epitope-Specific CD8⫹ T Lymphocyte Responses in Simian Immunodeficiency Virus-Infected Rhesus Monkeys Michael H. Newberg, Kimberly J. McEvers, Darci A. Gorgone, Michelle A. Lifton, Susanne H. C. Baumeister, Ronald S. Veazey, Jo¨rn E. Schmitz, and Norman L. Letvin

329

Specificity of CD4⫹CD25⫹ Regulatory T Cell Function in Alloimmunity Alberto Sa´nchez-Fueyo, Sigrid Sandner, Antje Habicht, Christophe Mariat, James Kenny, Nicolas Degauque, Xin Xiao Zheng, Terry B. Strom, Laurence A. Turka, and Mohamed H. Sayegh

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237

335

Src-Like Adaptor Protein Regulates B Cell Development and Function Leonard L. Dragone, Margaret D. Myers, Carmen White, Tomasz Sosinowski, and Arthur Weiss

Molecular and Structural Immunology 346

An Engineered Human IgG1 Antibody with Longer Serum Half-Life Paul R. Hinton, Joanna M. Xiong, Mary G. Johlfs, Meina Tao Tang, Stephen Keller, and Naoya Tsurushita

357

Neonatally Primed Lymph Node, but Not Splenic T Cells, Display a Gly-Gly Motif within the TCR ␤-Chain Complementarity-Determining Region 3 That Controls Affinity and May Affect Lymphoid Organ Retention Jacque C. Caprio-Young, J. Jeremiah Bell, Hyun-Hee Lee, Jason Ellis, Danielle Nast, Gary Sayler, Booki Min, and Habib Zaghouani

365

Uracil DNA Glycosylase Disruption Blocks Ig Gene Conversion and Induces Transition Mutations Huseyin Saribasak, Nesibe Nur Saribasak, Fatih M. Ipek, Joachim W. Ellwart, Hiroshi Arakawa, and Jean-Marie Buerstedde

372

Nitration and Inactivation of IDO by Peroxynitrite

380

Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages Yuichi Sekine, Taro Yumioka, Tetsuya Yamamoto, Ryuta Muromoto, Seiyu Imoto, Kenji Sugiyma, Kenji Oritani, Kazuya Shimoda, Mayu Minoguchi, Shizuo Akira, Akihiko Yoshimura, and Tadashi Matsuda

Immunogenetics 390

Altered Self-Erythrocyte Recognition and Destruction in an Inbred Line of Tilapia (Oreochromis aureus) Andrey Shirak, Anna Bendersky, Gideon Hulata, Micha Ron, and Ramy R. Avtalion

395

A Signal Adaptor SLAM-Associated Protein Regulates Spontaneous Autoimmunity and Fas-Dependent Lymphoproliferation in MRL-Faslpr Lupus Mice Hiroaki Komori, Hiroshi Furukawa, Shiro Mori, Mitsuko R. Ito, Miho Terada, Ming-Cai Zhang, Naoto Ishii, Nobuhiro Sakuma, Masato Nose, and Masao Ono

401

Defining the Origins and Evolution of the Chemokine/Chemokine Receptor System Mark E. DeVries, Alyson A. Kelvin, Luoling Xu, Longsi Ran, John Robinson, and David J. Kelvin

Host Defense 416

Antimicrobial Activity of Native and Synthetic Surfactant Protein B Peptides Marnie A. Ryan, Henry T. Akinbi, Alicia G. Serrano, Jesus Perez-Gil, Huixing Wu, Francis X. McCormack, and Timothy E. Weaver

426

Internalizing Antibodies to the C-Type Lectins, L-SIGN and DC-SIGN, Inhibit Viral Glycoprotein Binding and Deliver Antigen to Human Dendritic Cells for the Induction of T Cell Responses Naveen Dakappagari, Toshiaki Maruyama, Mark Renshaw, Paul Tacken, Carl Figdor, Ruurd Torensma, Martha A. Wild, Dayang Wu, Katherine Bowdish, and Anke Kretz-Rommel

441

Interaction of Mouse Dendritic Cells and Malaria-Infected Erythrocytes: Uptake, Maturation, and Antigen Presentation Rebecca Ing, Mariela Segura, Neeta Thawani, Mifong Tam, and Mary M. Stevenson

451

The Viral Protein A238L Inhibits TNF-␣ Expression through a CBP/p300 Transcriptional Coactivators Pathway Aitor G. Granja, Maria L. Nogal, Carolina Hurtado, Carmen del Aguila, Angel L. Carrascosa, Marı´a L. Salas, Manuel Fresno, and Yolanda Revilla

463

Effects of Immunization with CCR5-Based Cycloimmunogen on Simian/HIVSF162P3 Challenge Shogo Misumi, Daisuke Nakayama, Masashi Kusaba, Takaaki Iiboshi, Ryouzaburo Mukai, Kuniomi Tachibana, Tadashi Nakasone, Mamoru Umeda, Hideaki Shibata, Masafumi Endo, Nobutoki Takamune, and Shozo Shoji

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Hidetsugu Fujigaki, Kuniaki Saito, Felix Lin, Suwako Fujigaki, Kanako Takahashi, Brian M. Martin, Cai Y. Chen, Junichi Masuda, Jeffrey Kowalak, Osamu Takikawa, Mitsuru Seishima, and Sanford P. Markey

472

Helminth-Primed Dendritic Cells Alter the Host Response to Enteric Bacterial Infection Chien-Chang Chen, Steve Louie, Beth A. McCormick, W. Allan Walker, and Hai Ning Shi

484

Listeria monocytogenes Activated p38 MAPK and Induced IL-8 Secretion in a Nucleotide-Binding Oligomerization Domain 1-Dependent Manner in Endothelial Cells Bastian Opitz, Anja Pu¨schel, Wiebke Beermann, Andreas C. Hocke, Stefanie Fo¨rster, Bernd Schmeck, Vincent van Laak, Trinad Chakraborty, Norbert Suttorp, and Stefan Hippenstiel

491

Functional Importance of Regional Differences in Localized Gene Expression of Receptors for IL-13 in Murine Gut Motoko Morimoto, Masahiro Morimoto, Aiping Zhao, Kathleen B. Madden, Harry Dawson, Fred D. Finkelman, Margaret Mentink-Kane, Joseph F. Urban, Jr., Thomas A. Wynn, and Terez Shea-Donohue

496

CD154 Is Essential for Protective Immunity in Experimental Salmonella Infection: Evidence for a Dual Role in Innate and Adaptive Immune Responses Basel K. al-Ramadi, Maria J. Fernandez-Cabezudo, Azim Ullah, Hussain El-Hasasna, and Richard A. Flavell

507

IL-15 Regulates CD8⫹ T Cell Contraction during Primary Infection Toshiki Yajima, Kazufumi Yoshihara, Kenji Nakazato, Shino Kumabe, Shigeo Koyasu, Subash Sad, Hao Shen, Hiroyuki Kuwano, and Yasunobu Yoshikai

Neuronal Nitric Oxide Synthase Is Necessary for Elimination of Giardia lamblia Infections in Mice Erqiu Li, Ping Zhou, and Steven M. Singer

522

Endotoxin-Induced Expression of Murine Bactericidal Permeability/Increasing Protein Is Mediated Exclusively by Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-␤-Dependent Pathways Melanie Eckert, Irene Wittmann, Martin Ro¨llinghoff, Andre´ Gessner, and Markus Schnare

529

CD4⫹ T Lymphocytes Expressing CD40 Ligand Help the IgM Antibody Response to Soluble Pneumococcal Polysaccharides via an Intermediate Cell Type Axel Jeurissen, An D. Billiau, Leen Moens, Li Shengqiao, Willy Landuyt, Greet Wuyts, Louis Boon, Mark Waer, Jan L. Ceuppens, and Xavier Bossuyt

537

Memory T Cell Populations in the Lung Airways Are Maintained by Continual Recruitment Kenneth H. Ely, Tres Cookenham, Alan D. Roberts, and David L. Woodland

544

Identification and Characterization of U83A Viral Chemokine, a Broad and Potent ␤-Chemokine Agonist for Human CCRs with Unique Selectivity and Inhibition by Spliced Isoform David R. Dewin, Julie Catusse, and Ursula A. Gompels

Inflammation 557

Chemotactic Responses of IL-4-, IL-10-, and IFN-␥-Producing CD4⫹ T Cells Depend on Tissue Origin and Microbial Stimulus Gudrun F. Debes, Martin E. Dahl, Azita J. Mahiny, Kerstin Bonhagen, Daniel J. Campbell, Kerstin Siegmund, Klaus J. Erb, David B. Lewis, Thomas Kamradt, and Alf Hamann

567

Doxycycline Modulates Nitric Oxide Production in Murine Lung Epithelial Cells Jeffrey C. Hoyt, Janelle Ballering, Hiroki Numanami, John M. Hayden, and Richard A. Robbins

573

Lipoteichoic Acid-Induced Nitric Oxide Production Depends on the Activation of Platelet-Activating Factor Receptor and Jak2 Seung Hyun Han, Je Hak Kim, Ho Seong Seo, Michael H. Martin, Gook-Hyun Chung, Suzanne M. Michalek, and Moon H. Nahm

580

Lipopolysaccharide Induces Cyclooxygenase-2 in Intestinal Epithelium via a Noncanonical p38 MAPK Pathway Anatoly V. Grishin, Jin Wang, Douglas A. Potoka, David J. Hackam, Jeffrey S. Upperman, Patricia Boyle, Ruben Zamora, and Henri R. Ford

589

Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion Domingo F. Barber, Almira Bartolome´, Carmen Hernandez, Juana M. Flores, Cristina Fernandez-Arias, Luis Rodrı´guez-Borlado, Emilio Hirsch, Matthias Wymann, Dimitrios Balomenos, and Ana C. Carrera

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516

594

Ligation of CD28 Stimulates the Formation of a Multimeric Signaling Complex Involving Grb-2Associated Binder 2 (Gab2), Src Homology Phosphatase-2, and Phosphatidylinositol 3-Kinase: Evidence That Negative Regulation of CD28 Signaling Requires the Gab2 Pleckstrin Homology Domain Richard V. Parry, Gillian C. Whittaker, Martin Sims, Christine E. Edmead, Melanie J. Welham, and Stephen G. Ward

603

NF-␬B and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1␤Induced TGF-␤1 Gene Transcription Kang-Yun Lee, Kazuhiro Ito, Ryuji Hayashi, Elen P. I. Jazrawi, Peter J. Barnes, and Ian M. Adcock

616

Molecular Characterization of Rat Leukocyte P-Selectin Glycoprotein Ligand-1 and Effect of Its Blockade: Protection from Ischemia-Reperfusion Injury in Liver Transplantation Sei-ichiro Tsuchihashi, Constantino Fondevila, Gray D. Shaw, Meike Lorenze, Kimberly Marquette, Susan Benard, Xiu-Da Shen, Bibo Ke, Ronald W. Busuttil, and Jerzy W. Kupiec-Weglinski

625

Bacterial-Responsive B Lymphocytes Induce Periodontal Bone Resorption Xiaozhe Han, Toshihisa Kawai, Jean W. Eastcott, and Martin A. Taubman

Clinical Immunology 632

Yuyang Fu, Chun Xie, Jianlin Chen, Jiankun Zhu, Hui Zhou, James Thomas, Xin J. Zhou, and Chandra Mohan

640

Azathioprine Suppresses Ezrin-Radixin-Moesin-Dependent T Cell-APC Conjugation through Inhibition of Vav Guanosine Exchange Activity on Rac Proteins Daniela Poppe, Imke Tiede, Gerhard Fritz, Christoph Becker, Brigitte Bartsch, Stefan Wirtz, Dennis Strand, Shinya Tanaka, Peter R. Galle, Xose´ R. Bustelo, and Markus F. Neurath

652

SC5 mAb Represents a Unique Tool for the Detection of Extracellular Vimentin as a Specific Marker of Se´zary Cells Delphine Huet, Martine Bagot, Denis Loyaux, Joe¨l Capdevielle, Laurence Conraux, Pascual Ferrara, Armand Bensussan, and Anne Marie-Cardine

660

Models of Systemic Lupus Erythematosus: Development of Autoimmunity Following Peptide Immunizations of Noninbred Pedigreed Rabbits Geeta Rai, Satyajit Ray, Robyn E. Shaw, Paula F. DeGrange, Rose G. Mage, and Barbara A. Newman

668

Targeted Expression of the Human Thyrotropin Receptor A-Subunit to the Mouse Thyroid: Insight into Overcoming the Lack of Response to A-Subunit Adenovirus Immunization Pavel N. Pichurin, Chun-Rong Chen, Gregorio D. Chazenbalk, Holly Aliesky, Nancy Pham, Basil Rapoport, and Sandra M. McLachlan

677

Corrections

678

Author Index

681

Information for Authors

691

AAI Membership Application

692

AAI Trainee Membership Application

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Innate Stimuli Accentuate End-Organ Damage by Nephrotoxic Antibodies via Fc Receptor and TLR Stimulation and IL-1/TNF-␣ Production